diazepam has been researched along with Amyotrophic Lateral Sclerosis in 5 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole is an antiglutamatergic agent and the only drug to offer some effect on the life expectancy of ALS patients." | 5.46 | Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam. ( Andreasen, SR; Christensen, TB; Holm, MM; Lundbye, CJ; Schmitt-John, T; Thielsen, KD, 2017) |
| "Intrathecal baclofen (ITB) is a proven, effective treatment for refractory spasticity and chronic pain, with applications ranging from spinal cord injury to amyotrophic lateralsclerosis (ALS)." | 4.31 | Management of high-dose intrathecal baclofen pump explant: A case report. ( Agrawal, M; Belisle Haley, C; Dayal, R; Newton, K; Yeung, B, 2023) |
| "Riluzole is an antiglutamatergic agent and the only drug to offer some effect on the life expectancy of ALS patients." | 1.46 | Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam. ( Andreasen, SR; Christensen, TB; Holm, MM; Lundbye, CJ; Schmitt-John, T; Thielsen, KD, 2017) |
| "Diazepam was administered, which decreased both the number of PSH attacks and the catecholamine levels." | 1.46 | [Treatment for paroxysmal sympathetic hyperactivity in amyotrophic lateral sclerosis patient]. ( Ando, T; Ishikawa, S; Yokoi, K, 2017) |
| "Cramps were quite easily induced by volitional exertion and high-frequency stimulation of the peripheral nerves." | 1.29 | Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation. ( Matsuoka, H; Mizoguchi, K; Nishimura, Y; Obi, T; Takatsu, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belisle Haley, C | 1 |
| Agrawal, M | 1 |
| Newton, K | 1 |
| Yeung, B | 1 |
| Dayal, R | 1 |
| Andreasen, SR | 1 |
| Lundbye, CJ | 1 |
| Christensen, TB | 1 |
| Thielsen, KD | 1 |
| Schmitt-John, T | 1 |
| Holm, MM | 1 |
| Yokoi, K | 1 |
| Ando, T | 1 |
| Ishikawa, S | 1 |
| Obi, T | 1 |
| Mizoguchi, K | 1 |
| Matsuoka, H | 1 |
| Takatsu, M | 1 |
| Nishimura, Y | 1 |
| Caramia, MD | 1 |
| Palmieri, MG | 1 |
| Desiato, MT | 1 |
| Iani, C | 1 |
| Scalise, A | 1 |
| Telera, S | 1 |
| Bernardi, G | 1 |
1 trial available for diazepam and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Pharmacologic reversal of cortical hyperexcitability in patients with ALS.
Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Cerebral Cortex; Cyclohexanecarboxylic Acids; Diaze | 2000 |
4 other studies available for diazepam and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Management of high-dose intrathecal baclofen pump explant: A case report.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Chronic Pain; Diazepam; Humans; Infusion Pumps, Implantable | 2023 |
Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam.
Topics: Amyotrophic Lateral Sclerosis; Animals; Diazepam; Disease Models, Animal; Hippocampus; Mice, Inbred | 2017 |
[Treatment for paroxysmal sympathetic hyperactivity in amyotrophic lateral sclerosis patient].
Topics: Aged, 80 and over; Amyotrophic Lateral Sclerosis; Autonomic Nervous System Diseases; Catecholamines; | 2017 |
Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Clomipramine; Diazepam; Electric Stimulation; Evoked Potent | 1993 |