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diazepam and Alloxan Diabetes

diazepam has been researched along with Alloxan Diabetes in 15 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

ExcerptRelevanceReference
"However, the effects of the seizures, as well as possible treatment strategies, have yet to be elucidated, particularly in juvenile or insulin-dependent diabetes mellitus (IDDM)."1.39Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality. ( Carlen, PL; del Campo, M; El-Hayek, Y; Giacca, A; Hazrati, L; Maheandiran, M; Mylvaganam, S; Sugumar, S; Wu, C; Zhang, L, 2013)
"Pretreatment with diazepam (0."1.31Socio-psychological stress-induced antinociception in diabetic mice. ( Kamei, J; Ohsawa, M, 2000)
"Diazepam was the only drug to increase the fasting blood glucose concentration of diabetic rats."1.30GABA agonists differentially modify blood glucose levels of diabetic rats. ( Asnis, N; Barros, HM; Gomez, R; Tannhauser, SL, 1999)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's4 (26.67)18.2507
2000's4 (26.67)29.6817
2010's4 (26.67)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Rahmani, G1
Farajdokht, F1
Mohaddes, G1
Babri, S1
Ebrahimi, V1
Ebrahimi, H1
López-Rubalcava, C1
Paez-Martinez, N1
Oikawa, J1
Maheandiran, M1
Mylvaganam, S1
Wu, C1
El-Hayek, Y1
Sugumar, S1
Hazrati, L1
del Campo, M1
Giacca, A1
Zhang, L1
Carlen, PL1
Gupta, D1
Radhakrishnan, M1
Kurhe, Y1
Garabadu, D1
Krishnamurthy, S1
Kamei, J5
Miyata, S2
Morita, K1
Saitoh, A1
Takeda, H2
Hirano, S1
Andrews, SM1
Griffiths, LA1
Ramanathan, M1
Jaiswal, AK1
Bhattacharya, SK1
Ohsawa, M3
Gomez, R1
Asnis, N1
Tannhauser, SL1
Barros, HM1
Tsuji, M1
Matsumiya, T1
Lin, TH1
Lin, JH1
McNamara, PJ1
Blouin, RA1
Brazzell, RK1

Other Studies

15 other studies available for diazepam and Alloxan Diabetes

ArticleYear
Garlic (
    Archives of physiology and biochemistry, 2020, Volume: 126, Issue:2

    Topics: Animals; Antidepressive Agents; Antioxidants; Anxiety; Brain; Depressive Disorder; Diabetes Mellitus

2020
Blockade of corticosteroid receptors induces anxiolytic-like effects in streptozotocin-induced diabetic mice, and synergizes with diazepam.
    Behavioural pharmacology, 2013, Volume: 24, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Dos

2013
Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Electroencephalography; Glucose;

2013
Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice.
    Metabolic brain disease, 2014, Volume: 29, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimen

2014
Diazepam potentiates the antidiabetic, antistress and anxiolytic activities of metformin in type-2 diabetes mellitus with cooccurring stress in experimental animals.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Anti-Anxiety Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diazepam;

2014
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Blood Glucose; Body Weight; Desipramine;

2003
Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice.
    Psychopharmacology, 2006, Volume: 186, Issue:1

    Topics: Amphetamines; Animals; Azides; Behavior, Animal; Benzodiazepines; Bicuculline; Diabetes Mellitus, Ex

2006
The metabolism and disposition of [2-14C]diazepam in the streptozotocin-diabetic rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:10

    Topics: Animals; Bile; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Diabetes Mellitus,

1984
Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats.
    Psychopharmacology, 1998, Volume: 135, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Blood Glucose; Brain Chemistry; Diabetes Mellitus, Experimental; Diaze

1998
Modification of the effect of diazepam on the propofol-induced loss of the righting reflex in mice by diabetes.
    Brain research, 1999, Jul-03, Volume: 833, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Modul

1999
GABA agonists differentially modify blood glucose levels of diabetic rats.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:4

    Topics: Aminooxyacetic Acid; Animals; Baclofen; Benzodiazepines; Blood Glucose; Diabetes Mellitus, Experimen

1999
Socio-psychological stress-induced antinociception in diabetic mice.
    Psychopharmacology, 2000, Volume: 149, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Carbolines; Convulsants; Diabetes Mellitus, Experim

2000
Modification of the effects of benzodiazepines on the exploratory behaviors of mice on a hole-board by diabetes.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Carbolines; Convulsants; Diabetes Mellitus, Experimental; Diazepam; Do

2001
Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Blood-Brain Barrier; Brain; Devaze

1990
The protein binding of phenytoin, propranolol, diazepam, and AL01576 (an aldose reductase inhibitor) in human and rat diabetic serum.
    Pharmaceutical research, 1988, Volume: 5, Issue:5

    Topics: Adult; Aldehyde Reductase; Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus; Diabetes Melli

1988