Page last updated: 2024-10-25

diazepam and Aging

diazepam has been researched along with Aging in 131 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" In summary, the results indicate that the behavioral effects of diazepam vary with dosage and age of the rat."5.27Effect of aging on anticonflict and CNS depressant activity of diazepam in rats. ( Buck, MA; Dougan, JD; Farmer-Dougan, VA; Komiskey, HL; McSweeney, FK; Mundinger, KL, 1987)
" By contrast, the prototypical anxiolytic drug diazepam reduced social play at doses that reduced anxiety."3.75Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms. ( Baarendse, PJ; Trezza, V; Vanderschuren, LJ, 2009)
" Elevated plus-maze and passive-avoidance apparatus served as the exteroceptive behavioral models, and diazepam-, scopolamine-, and aging-induced amnesia served as the interoceptive behavioral models."3.72Ascorbic Acid: a promising memory-enhancer in mice. ( Dhingra, D; Parle, M, 2003)
"Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex."3.67Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice. ( Forster, MJ; Lal, H; Popper, MD; Retz, KC, 1986)
" To determine whether age-related changes in alpha 1-acid glycoprotein influence drug binding in mother and newborn infant and also the effects of sex, pregnancy, and oral contraceptives on drug binding, the binding of lidocaine, diazepam, propranolol, d-tubocurarine, and metocurine was determined by equilibrium dialysis in 17 men, 16 nonpregnant women, 16 nonpregnant women on oral contraceptives, and 15 mothers and their newborn infants at delivery."3.66Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant. ( Wood, AJ; Wood, M, 1981)
"Published data on the effect of cirrhosis on diazepam pharmacokinetics were reanalyzed to determine how age, sex, and body weight might have influenced the conclusions."3.66Factors influencing diazepam pharmacokinetics: age, sex, and liver disease. ( Greenblatt, DJ; Harmatz, JS; Shader, RI, 1978)
"Age-related changes in disposition of diazepam and its principal active metabolite, desmethyldiazepam (DMDZ), during and after extended dosage with diazepam were studied in healthy volunteers."3.01Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly. ( Chen, Y; Greenblatt, DJ; Harmatz, JS; Shader, RI; Zhang, Q, 2021)
"Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies."2.35Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976)
" These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures."1.51Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019)
"CSL also reversed successfully the memory deficits induced by scopolamine (0."1.37Reversal of memory deficits by Coriandrum sativum leaves in mice. ( Abdul Majeed, AB; Mani, V; Parle, M; Ramasamy, K, 2011)
"Factors likely to affect the pharmacokinetic disposition of diazepam in foals, such as body composition and hepatic enzyme activity, are in transition during the first 21 days of life."1.30Age-related changes in the pharmacokinetic disposition of diazepam in foals. ( Court, MH; Greenblatt, DJ; Norman, WM, 1997)
"When diazepam was given for sedative purpose in neonates and infants, the in-vivo urinary excretion of desmethyl diazepam, temazepam and oxazepam was extremely low in 1-2 day newborns (less than 5 nmol metabolites excreted in 24 h per kg body weight) and developed in the first week after birth."1.30Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. ( Cheron, G; Cresteil, T; Gueret, G; Sonnier, M; Treluyer, JM, 1997)
"Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e."1.29Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters. ( Löscher, W; Richter, A, 1993)
"For salicylic acid, n was 1."1.28Binding of diazepam, salicylic acid and digitoxin to albumin isolated from fetal and adult serum. ( Cappiello, M; Pacifici, GM; Viani, A, 1991)
" Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects."1.28Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990)
" Absolute bioavailability averaged 94%, indicating essentially complete absorption."1.27Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex. ( Divoll, M; Greenblatt, DJ; Ochs, HR; Shader, RI, 1983)
"3."1.27Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time. ( Niles, LP; Pickering, DS; Pulido, OM, 1988)
"Pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-HT in brain continued to remain high."1.27Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. ( Dey, PK; Sharma, HS, 1986)
"The diazepam stimuli were dose-dependent in each group."1.27A comparison of diazepam stimuli in aged and adult rats. ( Amrick, CL; Bennett, DA, 1987)
" Increases in pharmacologic effect that occur with aging may be caused by alterations in pharmacokinetic parameters or changes at the site of drug action."1.27Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats. ( Cooper, RL; Guthrie, S; Linnoila, M; Thurman, R, 1987)
" Increasing the intravenous dose of omeprazole from 10 mg to 40 mg had no significant effect on the pharmacokinetic parameters determined."1.27Pharmacokinetics and metabolism of omeprazole in man. ( Regårdh, CG, 1986)
"The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients."1.26[Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981)
" The terminal plasma half-life of diazepam ranged from 15."1.26The effect of age on the pharmacokinetics of diazepam. ( Barton, M; James, O; Macklon, AF; Rawlins, MD, 1980)
"Diazepam was metabolized by human foetal liver microsomes to N-desmethyldiazepam and N-methyloxazepam as early as the 13th week of gestation."1.26Dizepam metabolism in human foetal and adult liver. ( Ackermann, E; Richter, K, 1977)
" Despite the profound prolongation of t 1/2 (theta) with age, the constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary."1.25The effects of age and liver disease on the disposition and elimination of diazepam in adult man. ( Avant, GR; Hoyumpa, A; Klotz, U; Schenker, S; Wilkinson, GR, 1975)

Research

Studies (131)

TimeframeStudies, this research(%)All Research%
pre-199068 (51.91)18.7374
1990's31 (23.66)18.2507
2000's17 (12.98)29.6817
2010's14 (10.69)24.3611
2020's1 (0.76)2.80

Authors

AuthorsStudies
Greenblatt, DJ5
Harmatz, JS2
Zhang, Q1
Chen, Y1
Shader, RI3
Nakayama, H1
Abe, M1
Morimoto, C1
Iida, T1
Okabe, S1
Sakimura, K1
Hashimoto, K1
Matson, L1
Dunn, E1
Haines, K1
Miller-Smith, S1
Lee-Stubbs, R1
Whitten, K1
Ardinger, C1
McCarren, H1
McDonough, J1
El-Hayek, YH1
Wu, C1
Ye, H1
Wang, J1
Carlen, PL1
Zhang, L1
Lee, CY1
Liou, HH1
Cueto-Escobedo, J1
Contreras, CM1
Bernal-Morales, B1
Guillén-Ruiz, G1
Rodríguez-Landa, JF1
Koyanagi, T1
Yamaura, Y1
Yano, K1
Kim, S1
Yamazaki, H1
Stodieck, SK1
Greifzu, F1
Goetze, B1
Schmidt, KF1
Löwel, S1
Wakabayashi, C1
Numakawa, T1
Odaka, H1
Ooshima, Y1
Kiyama, Y1
Manabe, T1
Kunugi, H1
Iwakura, Y1
López-Granero, C1
Ruiz-Muñoz, AM1
Nieto-Escámez, FA1
Colomina, MT1
Aschner, M1
Sánchez-Santed, F1
Trezza, V1
Baarendse, PJ1
Vanderschuren, LJ1
Mani, V1
Parle, M3
Ramasamy, K1
Abdul Majeed, AB1
Olvera-Hernández, S1
Fernández-Guasti, A1
Panhelainen, AE1
Korpi, ER2
Liu, L1
Qian, XH1
Feng, GD1
Wu, MM1
Yang, AA1
Jiao, XY1
You, SW1
Ju, G1
Mitchell, SJ1
Huizer-Pajkos, A1
Cogger, VC1
McLachlan, AJ1
Le Couteur, DG1
Jones, B1
de Cabo, R1
Hilmer, SN1
Cannizzaro, C1
Martire, M1
Cannizzaro, E1
Monastero, R1
Gagliano, M1
Mineo, A1
Provenzano, G1
KANJILAL, GC1
Dhingra, D1
Echizenya, M2
Mishima, K2
Satoh, K2
Kusanagi, H2
Sekine, A1
Ohkubo, T2
Shimizu, T2
Hishikawa, Y1
Yasuda, K1
Joshi, H1
Tonkiss, J1
Galler, J1
Li, Y1
Zhu, S1
Hahn, RG1
Jacobson-Pick, S1
Elkobi, A1
Vander, S1
Rosenblum, K1
Richter-Levin, G1
Telang, S1
Fuller, G1
Wiggins, R1
Enna, SJ1
Vozeh, S1
Saito, K1
Goto, M1
Fukuda, H1
Aldinio, C1
Balzano, M1
Savoini, G2
Leon, A1
Toffano, G3
Calderini, G2
Bonetti, AC1
Aldinio, A1
Di Perri, B1
Biggio, G2
Tsang, CC1
Speeg, KV1
Wilkinson, GR3
Guarneri, P1
Corda, MG3
Concas, A1
Salis, M1
Lal, H2
Mann, P1
Gianforcaro, R1
Nandy, K1
Acs, Z1
Makara, GB1
Stark, E1
Meyer, BR1
Morselli, PL2
Franco-Morselli, R1
Komiskey, HL4
Cook, TM1
Lin, CF1
Hayton, WL1
Cochrane, LA1
Nicholson, AN1
Stone, BM2
Divoll, M1
Ochs, HR1
Ernst, K1
Sung, SC1
Saneyoshi, M1
Clark, SM1
Lipton, JM1
Heusner, JE1
Bosmann, HB1
Nau, H1
Liddiard, C1
Macklon, AF1
Barton, M1
James, O1
Rawlins, MD1
Mayevsky, A1
Shaya, B1
Gersdorff, MC1
Wood, M1
Wood, AJ1
Schroeder, H1
Nolte, A1
Boyet, S1
Koziel, V1
Nehlig, A1
Giorgi, O2
Cancedda, E2
Lecca, D1
Orlandi, M1
Benesová, O1
Tejkalová, H1
Kristofiková, Z1
Klaschka, J1
Dostál, M1
Aguayo, LG1
Alarcón, JM1
Richter, A1
Löscher, W1
Kellogg, CK2
Taylor, MK1
Rodriguez-Zafra, M2
Pleger, GL2
Uusi-Oukari, M1
Kaivola, J1
Yakushiji, T1
Shirasaki, T1
Munakata, M1
Hirata, A1
Akaike, N1
Korkmaz, S1
Carlsson, S1
Wahlström, G1
Pletnikov, MV1
Storozheva, ZI1
Sherstnev, VV1
Meh, D1
Denislic, M1
McNamara, RK1
Davis, TM1
Skelton, RW1
Obata, K1
Norman, WM1
Court, MH1
Treluyer, JM1
Gueret, G1
Cheron, G1
Sonnier, M1
Cresteil, T1
Paróczai, M1
Kiss, B1
Kárpáti, E1
da Silva, LF1
Pereira, P1
Elisabetsky, E1
Borde, N1
Jaffard, R1
Béracochéa, D1
Puoliväli, J1
Pradier, L1
Riekkinen, P1
Masuda, Y1
Suzuki, M1
Akagawa, Y1
Takemura, T1
Fukura, H1
Kitani, Y1
Komiya, Y1
Igarashi, M1
Taketo, M1
Yoshioka, T1
Fagiolini, M1
Hensch, TK1
Vanakoski, J1
Mattila, MJ1
Seppälä, T1
Bazyan, AS1
Zhulin, VV1
Karpova, MN1
Klishina, NY1
Glebov, RN1
Wikinski, SI1
Acosta, GB1
Gravielle, MC1
Bonavita, CD1
Bisagno, V1
Fiszer de Plazas, S1
Rubio, MC1
Hevers, W1
Lüddens, H1
Chopin, P1
Colpaert, FC1
Marien, M1
Hoyumpa, AM1
Schenker, S2
Kanto, J1
Sellman, R1
Haataja, M1
Hurme, P1
Klotz, U3
Müller-Seydlitz, P1
Giles, HG2
MacLeod, SM2
Wright, JR1
Sellers, EM2
Reidenberg, MM1
Levy, M1
Warner, H1
Coutinho, CB1
Schwartz, MA1
Yu, G1
Cheripko, J1
Lippa, AS1
Sano, MC1
Coupet, J1
Klepner, CA1
Beer, B1
Bengert, B1
Liu, FF1
Candy, JM1
Martin, IL1
Hvidberg, EF1
Dam, M1
Ackermann, E1
Richter, K1
Avant, GR1
Hoyumpa, A1
McDonald, JW1
Trescher, WH1
Johnston, MV1
Viani, A2
Rizzo, G1
Carrai, M1
Pacifici, GM2
Jänicke, B2
Coper, H2
Fujita, S2
Cappiello, M1
Segovia, S1
Pérez-Laso, C1
Calés, JM1
Del Abril, A1
De Blas, MR1
Collado, P1
Valencia, A1
Guillamón, A1
Anschütz, F1
Nicholson, PA1
Karim, A1
Smith, M1
Gruen, RJ1
Deutch, AY1
Roth, RH1
Caboche, J1
Mitrovic, N1
Le Saux, F1
Besson, MJ1
Sauter, A1
Maurin, Y1
Morimoto, R1
Chiba, M1
Kitani, K1
Suzuki, T1
Pomara, N2
Deptula, D2
Medel, M1
Block, RI1
Niles, LP1
Pulido, OM1
Pickering, DS1
Raemont, LM1
Mundinger, KL2
Frieder, B1
Grimm, VE1
Bareggi, SR1
Nielsen, NP1
Leva, S1
Pirola, R1
Zecca, L1
Lorini, M1
Sharma, HS1
Dey, PK1
Shibuya, T1
Watanabe, Y1
Hill, HF1
Salafsky, B1
Sieghart, W1
Hinrichs, JV1
Ghoneim, MM1
Amrick, CL1
Bennett, DA1
Buck, MA1
McSweeney, FK1
Farmer-Dougan, VA1
Dougan, JD1
Rubinstein, S1
Stanley, B1
Stanley, M1
Schulze, G1
Guthrie, S1
Cooper, RL1
Thurman, R1
Linnoila, M1
Regårdh, CG1
Su, MQ1
Yu, S1
Leiter, JC1
Knuth, SL1
Krol, RC1
Bartlett, D1
Swift, CG1
Ewen, JM1
Clarke, P1
Stevenson, IH1
de Wit, H1
Uhlenhuth, EH1
Johanson, CE1
Forster, MJ1
Retz, KC1
Popper, MD1
Davis, D1
Grossman, SH1
Kitchell, BB1
Shand, DG1
Routledge, PA1
Cromwell, HA1

Reviews

5 reviews available for diazepam and Aging

ArticleYear
[Benzodiazepine (clonazepam, nitrazepam, diazepam)].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 12

    Topics: Aging; Anticonvulsants; Biomarkers; Chromatography, Gas; Chromatography, High Pressure Liquid; Clona

2004
Benzodiazepines in the elderly.
    The Medical clinics of North America, 1982, Volume: 66, Issue:5

    Topics: Adult; Aged; Aging; Benzodiazepines; Diazepam; Female; Flurazepam; Humans; Kinetics; Male; Middle Ag

1982
Clinical pharmacokinetics of antiepileptic drugs in adults.
    Pharmacology & therapeutics, 1980, Volume: 10, Issue:1

    Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H

1980
Clinical pharmacokinetics of anticonvulsants.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam

1976
[Aging and drug metabolism: alteration of liver drug metabolizing ability in male rats. Is it functional deterioration or feminization of the liver?].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:11

    Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Electron Transport; Female; Feminization;

1991

Trials

9 trials available for diazepam and Aging

ArticleYear
Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly.
    Journal of clinical pharmacology, 2021, Volume: 61, Issue:2

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Diazepam; Female; Half-Life; Humans; Male; Metabolic Cleara

2021
Dissociation between objective psychomotor impairment and subjective sleepiness after diazepam administration in the aged people.
    Human psychopharmacology, 2007, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Analysis of Variance; Attention; Central Nervous System Depressants;

2007
Variability of response to hypnotics: sleep studies in man.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Aging; Diazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sleep; Sleep

1983
Driving under light and dark conditions: effects of alcohol and diazepam in young and older subjects.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:6-7

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Automobile Driving; Central Nervous System Depressants; Cro

2000
Effects of diazepam on recall memory: relationship to aging, dose, and duration of treatment.
    Psychopharmacology bulletin, 1989, Volume: 25, Issue:1

    Topics: Adult; Aged; Aging; Diazepam; Female; Humans; Male; Memory Disorders; Middle Aged; Time Factors

1989
Diazepam, behavior, and aging: increased sensitivity or lower baseline performance?
    Psychopharmacology, 1987, Volume: 92, Issue:1

    Topics: Adult; Aged; Aging; Animals; Behavior, Animal; Diazepam; Emotions; Female; Humans; Learning; Male; M

1987
The effect of diazepam on genioglossal muscle activity in normal human subjects.
    The American review of respiratory disease, 1985, Volume: 132, Issue:2

    Topics: Adult; Aging; Carbon Dioxide; Diazepam; Double-Blind Method; Electromyography; Humans; Male; Middle

1985
Drug preference in normal volunteers: effects of age and time of day.
    Psychopharmacology, 1985, Volume: 87, Issue:2

    Topics: Adult; Aging; Amphetamine; Diazepam; Drug Interactions; Emotions; Humans; Middle Aged; Reinforcement

1985
Management of anxiety-depression in geriatric patients.
    Medical times, 1973, Volume: 101, Issue:1

    Topics: Adjustment Disorders; Aged; Aging; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Middle

1973

Other Studies

117 other studies available for diazepam and Aging

ArticleYear
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum.
    Nature communications, 2018, 07-19, Volume: 9, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium-Binding Proteins; Cell Communication; Cerebellum;

2018
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
    Neurotoxicology, 2019, Volume: 74

    Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect

2019
Hippocampal excitability is increased in aged mice.
    Experimental neurology, 2013, Volume: 247

    Topics: Action Potentials; Age Factors; Aging; Animals; Biophysics; Brain Waves; Diazepam; Electric Stimulat

2013
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
    Neuroreport, 2013, Jul-10, Volume: 24, Issue:10

    Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop

2013
Defensive burying test in postweaning rats: use of a small round chamber.
    Behavioural pharmacology, 2013, Volume: 24, Issue:8

    Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Fe

2013
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
    Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:10

    Topics: Acetaminophen; Age Factors; Aging; Albumins; Animals; Antipyrine; Blood Proteins; Diazepam; Diphenhy

2014
Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke.
    Experimental gerontology, 2014, Volume: 60

    Topics: Aging; Animals; Contrast Sensitivity; Darkness; Diazepam; Dominance, Ocular; Female; Male; Mice; Mic

2014
IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging.
    Neuroscience letters, 2015, Jul-10, Volume: 599

    Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Biogenic Monoamines; Diazepam; Hippocampus; Interleuki

2015
Chronic dietary chlorpyrifos causes long-term spatial memory impairment and thigmotaxic behavior.
    Neurotoxicology, 2016, Volume: 53

    Topics: Aging; Animals; Anti-Anxiety Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cues; Diazepam; Dizoci

2016
Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:12

    Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants;

2009
Reversal of memory deficits by Coriandrum sativum leaves in mice.
    Journal of the science of food and agriculture, 2011, Jan-15, Volume: 91, Issue:1

    Topics: Aging; Animals; Anticholesteremic Agents; Avoidance Learning; Brain; Cholesterol; Cholinesterase Inh

2011
Sex differences in the burying behavior test in middle-aged rats: effects of diazepam.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4

    Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Electroshock; Estrous Cycl

2011
Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:1

    Topics: Aging; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dopaminergic Neurons; Gene Express

2012
Different neuroprotection and therapeutic time windows by two specific diazepam regimens on retinal ganglion cells after optic nerve transection in adult rats.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:4

    Topics: Aging; Animals; Axotomy; Cell Count; Cell Survival; Diazepam; Female; Injections, Intraperitoneal; N

2012
The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.
    Pharmacology, 2012, Volume: 90, Issue:5-6

    Topics: Aging; Animals; Diazepam; Endothelium; Liver; Male; Perfusion; Poloxamer; Rats; Rats, Inbred F344; S

2012
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze

2003
A CLINICAL EVALUATION OF 'VALIUM' (RO5-2807) IN CEREBRAL PALSY.
    The British journal of clinical practice, 1964, Volume: 18

    Topics: Adolescent; Aging; Cerebral Palsy; Child; Diazepam; Physical Therapy Modalities; Toxicology; Tranqui

1964
Ascorbic Acid: a promising memory-enhancer in mice.
    Journal of pharmacological sciences, 2003, Volume: 93, Issue:2

    Topics: Aging; Amnesia; Animals; Antioxidants; Anxiety; Ascorbic Acid; Avoidance Learning; Behavior, Animal;

2003
Enhanced heat loss and age-related hypersensitivity to diazepam.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Body Temperature Regulation; Cros

2004
Nardostachys jatamansi improves learning and memory in mice.
    Journal of medicinal food, 2006,Spring, Volume: 9, Issue:1

    Topics: Aging; Amnesia; Animals; Avoidance Learning; Behavior, Animal; Diazepam; Female; Learning; Male; Maz

2006
Prenatal malnutrition alters diazepam-mediated suppression of ultrasonic vocalizations in an age dependent manner.
    Behavioural brain research, 2007, Sep-04, Volume: 182, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Body Wei

2007
The kinetics of Ringer's solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:7

    Topics: Adult; Aged; Aging; Algorithms; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intr

2007
Juvenile stress-induced alteration of maturation of the GABAA receptor alpha subunit in the rat.
    The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:7

    Topics: Aging; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Azepines; Behavior, Animal; Blotting, Wester

2008
Early undernutrition and [3H]gamma-aminobutyric acid binding in rat brain.
    Journal of neurochemistry, 1984, Volume: 43, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Hippoca

1984
[Pharmacokinetic of benzodiazepines in old age].
    Schweizerische medizinische Wochenschrift, 1981, Nov-21, Volume: 111, Issue:47

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M

1981
Effects of pentobarbital on [3H]diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
    Japanese journal of pharmacology, 1984, Volume: 36, Issue:2

    Topics: Aging; Animals; Anti-Anxiety Agents; Cerebellum; Cerebral Cortex; Diazepam; Female; In Vitro Techniq

1984
Ontogeny of 3H-diazepam binding sites in different rat brain area. Effect of GABA.
    Developmental neuroscience, 1981, Volume: 4, Issue:6

    Topics: Aging; Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Rats; Rats

1981
Functional interaction between benzodiazepine and GABA recognition sites in aged rats.
    Neurobiology of aging, 1981,Winter, Volume: 2, Issue:4

    Topics: Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Diazepam; gamma-Aminobutyric Acid; Organ Spec

1981
Aging and benzodiazepine binding in the rat cerebral cortex.
    Life sciences, 1982, Jan-25, Volume: 30, Issue:4

    Topics: Aging; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Female; In Vitro Techniques; Rats; Rats,

1982
Age-related changes of benzodiazepine and GABA binding sites in the rat retina.
    Neurobiology of aging, 1982,Fall, Volume: 3, Issue:3

    Topics: Aging; Animals; Diazepam; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Recepto

1982
Senescence related changes in brain diazepam binding and motor performance.
    Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4

    Topics: Aging; Animals; Cerebral Cortex; Diazepam; Mice; Motor Activity; Motor Skills; Receptors, Cell Surfa

1982
Diazepam tolerance.
    British medical journal (Clinical research ed.), 1984, Oct-20, Volume: 289, Issue:6451

    Topics: Adult; Aged; Aging; Biological Availability; Diazepam; Humans; Middle Aged

1984
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
    Life sciences, 1984, Apr-16, Volume: 34, Issue:16

    Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Diazepam; Female; GABA Antagonists; gamma-A

1984
Impairment of learning or memory in the mature and old rat by diazepam.
    Psychopharmacology, 1981, Volume: 73, Issue:3

    Topics: Aging; Animals; Depression, Chemical; Diazepam; Female; Learning; Memory; Rats; Rats, Inbred F344

1981
Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Diazepam; Female; Humans; Injecti

1983
[Psychiatric emergencies in general practice: medical and legal aspects (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1982, May-18, Volume: 71, Issue:20

    Topics: Aged; Aging; Anxiety; Confidentiality; Diazepam; Emergency Services, Psychiatric; Forensic Psychiatr

1982
Effect of synthetic purines and purine nucleosides on [3H]diazepam binding in brain.
    European journal of pharmacology, 1982, Jul-16, Volume: 81, Issue:3

    Topics: Aging; Animals; Binding, Competitive; Brain; Diazepam; In Vitro Techniques; Male; Membranes; Purine

1982
Effects of diazepam on body temperature of the aged squirrel monkey.
    Brain research bulletin, 1981, Volume: 7, Issue:1

    Topics: Aging; Animals; Body Temperature Regulation; Diazepam; Dose-Response Relationship, Drug; Injections,

1981
GABA stimulation of 3H-diazepam binding in aged mice.
    Life sciences, 1981, Aug-31, Volume: 29, Issue:9

    Topics: Aging; Animals; Brain; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membr

1981
Postnatal development of sex-dependent differences in the metabolism of diazepam by rat liver.
    Biochemical pharmacology, 1980, Volume: 29, Issue:3

    Topics: Aging; Animals; Biotransformation; Diazepam; Female; In Vitro Techniques; Kinetics; Liver; Male; Rat

1980
The effect of age on the pharmacokinetics of diazepam.
    Clinical science (London, England : 1979), 1980, Volume: 59, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Pr

1980
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1980, Volume: 49, Issue:4

    Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobar

1980
Dynamic study of the acoustico-facial reflex by impedance measurement.
    Archives of oto-rhino-laryngology, 1980, Volume: 228, Issue:2

    Topics: Acoustic Impedance Tests; Aging; Auditory Fatigue; Diazepam; Epilepsy; Humans; Hyperacusis; Loudness

1980
Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
    Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4

    Topics: Adult; Aging; Blood Proteins; Contraceptives, Oral; Diazepam; Female; Humans; Infant, Newborn; Lidoc

1981
Short- and long-term effects of neonatal diazepam exposure on local cerebral glucose utilization in the rat.
    Brain research, 1994, Oct-10, Volume: 660, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Brain; Diazepam; Energy Metabolism; Female; Glucose; Pharmaceutica

1994
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
    Brain research. Developmental brain research, 1994, Jul-15, Volume: 80, Issue:1-2

    Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compo

1994
Early postnatal diazepam treatment of rats and neuroimmunocompetence in adulthood and senescence.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aging; Animals; Behavior, Animal; Brain; Diazepam; Female; Immunocompetence; Male; Pregnancy; Rats;

1994
Modulation of 35S-TBPS binding by GABAergic drugs in the cerebral cortex of newborn and adult rats.
    Brain research bulletin, 1993, Volume: 32, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds,

1993
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag

1993
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
    European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1

    Topics: Aging; Aminooxyacetic Acid; Animals; Cricetinae; Diazepam; Dopamine Antagonists; Dystonia; Mesocrice

1993
Altered stressor-induced changes in GABAA receptor function in the cerebral cortex of adult rats exposed in utero to diazepam.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Chlorides; Diazepam; Female; Male; Pregnancy; Prenatal Exposure Del

1993
Postnatal development of diazepam-insensitive [3H]Ro 15-4513 binding sites.
    Neuroscience, 1993, Volume: 53, Issue:2

    Topics: Affinity Labels; Aging; Animals; Autoradiography; Azides; Benzodiazepines; Brain; Brain Chemistry; C

1993
Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones.
    British journal of pharmacology, 1993, Volume: 109, Issue:3

    Topics: Aging; Animals; Benzothiepins; Central Nervous System; Cerebral Cortex; Diazepam; gamma-Aminobutyric

1993
Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat.
    Brain research, 1993, Jan-15, Volume: 600, Issue:2

    Topics: Aging; Animals; Diazepam; Drug Tolerance; Electroencephalography; Hexobarbital; Male; Rats; Rats, Sp

1993
Relationship between memory and fear: developmental and pharmacological studies.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 54, Issue:1

    Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Diazepam; Fear; Female; Habituation, Psyc

1996
Influence of age, temperature, sex, height and diazepam on vibration perception.
    Journal of the neurological sciences, 1995, Volume: 134, Issue:1-2

    Topics: Adolescent; Adult; Aged; Aging; Body Height; Child; Diazepam; Female; Humans; Male; Middle Aged; Mot

1995
Effect of aging on the spatial learning deficit produced by diazepam in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1996, Volume: 20, Issue:5

    Topics: Aging; Animals; Anti-Anxiety Agents; Cues; Diazepam; Dose-Response Relationship, Drug; Male; Maze Le

1996
Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
    Developmental neuroscience, 1997, Volume: 19, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Calcium; Cell Count; Cerebellum; Diazepam; GABA Agent

1997
Age-related changes in the pharmacokinetic disposition of diazepam in foals.
    American journal of veterinary research, 1997, Volume: 58, Issue:8

    Topics: Adjuvants, Anesthesia; Aging; Animals; Diazepam; Female; Half-Life; Horses; Male; Metabolic Clearanc

1997
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.
    Pharmacogenetics, 1997, Volume: 7, Issue:6

    Topics: Adult; Aging; Child, Preschool; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Female;

1997
Effect of RGH-2716 on learning and memory deficits of young and aged rats in water-labyrinth.
    Brain research bulletin, 1998, Mar-15, Volume: 45, Issue:5

    Topics: Aging; Amnesia, Retrograde; Animals; Diazepam; Learning Disabilities; Male; Maze Learning; Memory; M

1998
A neuropharmacological analysis of PTZ-induced kindling in mice.
    General pharmacology, 1998, Volume: 31, Issue:1

    Topics: Aging; Animals; Anticonvulsants; Convulsants; Diazepam; Glutamic Acid; Kindling, Neurologic; Male; M

1998
Effects of chronic alcohol consumption or Diazepam administration on item recognition and temporal ordering in a spatial working memory task in mice.
    The European journal of neuroscience, 1998, Volume: 10, Issue:7

    Topics: Aging; Alcohol Drinking; Animals; Diazepam; Male; Memory; Mice; Mice, Inbred BALB C; Time Factors

1998
Moderate cortical EEG changes in apolipoprotein E-deficient mice during ageing and scopolamine treatment but not after nucleus basalis lesion.
    Psychopharmacology, 1999, Volume: 145, Issue:4

    Topics: Aging; Animals; Apolipoproteins E; Choline O-Acetyltransferase; Diazepam; Electroencephalography; Ma

1999
Developmental and pharmacological features of mouse emotional piloerection.
    Experimental animals, 1999, Volume: 48, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E

1999
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
    Journal of neuroscience research, 1999, Nov-01, Volume: 58, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob

1999
Developmental change of GABA(A) receptor-mediated current in rat hippocampus.
    Neuroscience, 2000, Volume: 96, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Diazepam; Electric Conductivity; Electric Stimulation; GABA Antago

2000
Inhibitory threshold for critical-period activation in primary visual cortex.
    Nature, 2000, Mar-09, Volume: 404, Issue:6774

    Topics: Aging; Animals; Critical Period, Psychological; Diazepam; gamma-Aminobutyric Acid; Haplorhini; Mice;

2000
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
    Brain research, 2001, Jan-12, Volume: 888, Issue:2

    Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil

2001
Diazepam fails to potentiate GABA-induced chloride uptake and to produce anxiolytic-like action in aged rats.
    Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:4

    Topics: Aging; Animals; Anti-Anxiety Agents; Cerebral Cortex; Chlorides; Diazepam; Dose-Response Relationshi

2001
Pharmacological heterogeneity of gamma-aminobutyric acid receptors during development suggests distinct classes of rat cerebellar granule cells in situ.
    Neuropharmacology, 2002, Volume: 42, Issue:1

    Topics: Aging; Algorithms; Animals; Bicuculline; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; E

2002
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:1

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Ag

2002
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
    Southern medical journal, 1978, Volume: 71 Suppl 2

    Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li

1978
Effects of liver disease and of aging on the disposition and elimination of sedatives.
    Transactions of the American Clinical and Climatological Association, 1978, Volume: 89

    Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral,

1978
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
    Acta psychiatrica Scandinavica. Supplementum, 1978, Issue:274

    Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H

1978
Diazepam and its hydroxylated metabolites: studies on sleep in healthy man.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Adult; Aging; Diazepam; Humans; Hydroxylation; Male; Middle Aged; Oxazepam; Sleep; Sleep, REM; Temaz

1979
Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:6

    Topics: Adult; Aging; Biotransformation; Child; Creatinine; Diazepam; Female; Humans; Infant; Infant, Newbor

1978
Altered elimination of desmethyldiazepam in the elderly.
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:1

    Topics: Adult; Aged; Aging; Diazepam; Half-Life; Humans; Liver; Nordazepam; Time Factors

1979
Effect of age on levels of diazepam in plasma and brain of rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 307, Issue:2

    Topics: Aging; Animals; Brain Chemistry; Cerebellum; Diazepam; Half-Life; Male; Rats; Time Factors

1979
Influence of age and previous use of diazepam dosage required for endoscopy.
    Canadian Medical Association journal, 1978, Mar-04, Volume: 118, Issue:5

    Topics: Adult; Aged; Aging; Body Surface Area; Diazepam; Endoscopy; Female; Humans; Injections, Intravenous;

1978
Relationship between diazepam dose, plasma level, age, and central nervous system depression.
    Clinical pharmacology and therapeutics, 1978, Volume: 23, Issue:4

    Topics: Adult; Aged; Aging; Central Nervous System; Depression, Chemical; Diazepam; Dose-Response Relationsh

1978
Factors influencing diazepam pharmacokinetics: age, sex, and liver disease.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:4

    Topics: Adult; Aged; Aging; Body Weight; Diazepam; Female; Galactose; Humans; Kinetics; Liver Diseases; Male

1978
Evidence that benzodiazepine receptors reside on cerebellar purkinje cells: studies with "nervous" mutant mice.
    Life sciences, 1978, Nov-27, Volume: 23, Issue:22

    Topics: Aging; Animals; Benzodiazepines; Diazepam; Male; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; P

1978
Age- and gender-related differences in diazepam pharmacokinetics.
    Journal of clinical pharmacology, 1979, Volume: 19, Issue:1

    Topics: Adult; Aged; Aging; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Sex Factors

1979
The postnatal development of the benzodiazepine receptor in the cerebral cortex and cerebellum of the rat.
    Journal of neurochemistry, 1979, Volume: 32, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Diazepam; Female; Kinetics; Male; Org

1979
Dizepam metabolism in human foetal and adult liver.
    European journal of clinical pharmacology, 1977, Volume: 11, Issue:1

    Topics: Aging; Carbon Monoxide; Dealkylation; Depression, Chemical; Diazepam; Female; Fetus; Gestational Age

1977
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aging; Alcoholism; Animals; Diazepam; Fe

1975
Proceedings: Drug disposition during development.
    Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:6

    Topics: Aging; Child Development; Child, Preschool; Diazepam; Half-Life; Humans; Infant; Infant, Newborn; Ph

1974
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
    Brain research, 1992, Jun-26, Volume: 583, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci

1992
The effect of ageing on plasma albumin and plasma protein binding of diazepam, salicylic acid and digitoxin in healthy subjects and patients with renal impairment.
    British journal of clinical pharmacology, 1992, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Proteins; Diazepam; Digitoxin; Humans; Kidn

1992
Effects of age and drugs on food and fluid intake.
    Growth, development, and aging : GDA, 1991,Fall, Volume: 55, Issue:3

    Topics: Aging; Amphetamines; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Diazepam; Drinking; Dr

1991
Binding of diazepam, salicylic acid and digitoxin to albumin isolated from fetal and adult serum.
    Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:1-2

    Topics: Adult; Aging; Binding Sites; Diazepam; Digitoxin; Fetus; Humans; Salicylates; Salicylic Acid; Serum

1991
Early postnatal diazepam exposure alters sex differences in the rat brain.
    Brain research bulletin, 1991, Volume: 26, Issue:6

    Topics: Aging; Animals; Body Weight; Brain; Diazepam; Female; Locus Coeruleus; Male; Neurons; Olfactory Bulb

1991
[Physiological changes of organs in old age].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1991, Volume: 46, Issue:12

    Topics: Aged; Aging; Diazepam; Humans; Mental Processes; Metabolic Clearance Rate; Morbidity; Pharmaceutical

1991
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
    The Journal of rheumatology. Supplement, 1990, Volume: 20

    Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug

1990
Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:1

    Topics: Aging; Animals; Brain; Diazepam; Dopamine; Exploratory Behavior; Female; Male; Pregnancy; Prenatal E

1990
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm

1989
Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats.
    Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22

    Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Female; Imipramine; Immunologic Techniques

1989
GABA-stimulated chloride uptake and enhancement by diazepam in synaptoneurosomes from rat brain during prenatal and postnatal development.
    Brain research. Developmental brain research, 1989, Sep-01, Volume: 49, Issue:1

    Topics: Aging; Animals; Brain; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; Rats; Synaptosomes

1989
Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:2-3

    Topics: Aging; Animals; Brain; Cerebral Cortex; Circadian Rhythm; Diazepam; gamma-Aminobutyric Acid; Kinetic

1988
Aging: modulation of GABAA binding sites by ethanol and diazepam.
    Brain research, 1988, Aug-16, Volume: 458, Issue:1

    Topics: Aging; Animals; Brain; Diazepam; Ethanol; Kinetics; Male; Rats; Rats, Inbred F344; Receptors, GABA-A

1988
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
    Journal of neurochemistry, 1985, Volume: 45, Issue:1

    Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus

1985
Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam).
    International journal of clinical pharmacology research, 1986, Volume: 6, Issue:4

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Diazepam; Female; Human

1986
Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection.
    Neurochemical research, 1987, Volume: 12, Issue:8

    Topics: Aging; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Kinetics;

1987
Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.
    Neuropharmacology, 1986, Volume: 25, Issue:2

    Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Cyproheptadine; Diazepam; Fem

1986
Developmental alterations in maturing rats caused by chronic prenatal and postnatal diazepam treatments.
    Japanese journal of pharmacology, 1986, Volume: 40, Issue:1

    Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Female; Male; Pre

1986
Comparison of benzodiazepine receptors in cerebellum and inferior colliculus.
    Journal of neurochemistry, 1986, Volume: 47, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Carbolines; Cell Membrane; Cerebellum; Clonazepam; Diazepam; Fluni

1986
A comparison of diazepam stimuli in aged and adult rats.
    Psychopharmacology, 1987, Volume: 93, Issue:3

    Topics: Aging; Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Dru

1987
Effect of aging on anticonflict and CNS depressant activity of diazepam in rats.
    Psychopharmacology, 1987, Volume: 93, Issue:4

    Topics: Aging; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Conflic

1987
The effects of diazepam and aging on intrusions.
    Psychopharmacology bulletin, 1988, Volume: 24, Issue:2

    Topics: Adult; Aged; Aging; Diazepam; Female; Humans; Male; Middle Aged; Psychomotor Performance

1988
Adaptivity as a paradigm for age-dependent changes exemplified by motor behavior.
    Annals of the New York Academy of Sciences, 1988, Volume: 515

    Topics: Adaptation, Physiological; Aging; Animals; Diazepam; Hypoxia; Motor Activity; Time Factors

1988
Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats.
    Pharmacology & toxicology, 1987, Volume: 61, Issue:5

    Topics: Aging; Animals; Brain Chemistry; Diazepam; Ethanol; Female; Pentobarbital; Rats; Sleep

1987
Pharmacokinetics and metabolism of omeprazole in man.
    Scandinavian journal of gastroenterology. Supplement, 1986, Volume: 118

    Topics: Administration, Oral; Aged; Aging; Anti-Ulcer Agents; Benzimidazoles; Diazepam; Dose-Response Relati

1986
Maternal diazepam exposure on brain ornithine decarboxylase and growth of offspring.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1986, Volume: 10, Issue:1

    Topics: Aging; Animals; Brain; Carbon Radioisotopes; Diazepam; Female; Maternal-Fetal Exchange; Ornithine De

1986
Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.
    British journal of clinical pharmacology, 1985, Volume: 20, Issue:2

    Topics: Adult; Aged; Aging; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedati

1985
Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice.
    Life sciences, 1986, Apr-14, Volume: 38, Issue:15

    Topics: Aging; Animals; Ataxia; Barbiturates; Body Weight; Diazepam; Dose-Response Relationship, Drug; Male;

1986
The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Diazepam; Female; Humans; Lidocaine; Male; Middle Aged; Orosomucoid;

1985