diazepam has been researched along with Aging in 131 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In summary, the results indicate that the behavioral effects of diazepam vary with dosage and age of the rat." | 5.27 | Effect of aging on anticonflict and CNS depressant activity of diazepam in rats. ( Buck, MA; Dougan, JD; Farmer-Dougan, VA; Komiskey, HL; McSweeney, FK; Mundinger, KL, 1987) |
| " By contrast, the prototypical anxiolytic drug diazepam reduced social play at doses that reduced anxiety." | 3.75 | Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms. ( Baarendse, PJ; Trezza, V; Vanderschuren, LJ, 2009) |
| " Elevated plus-maze and passive-avoidance apparatus served as the exteroceptive behavioral models, and diazepam-, scopolamine-, and aging-induced amnesia served as the interoceptive behavioral models." | 3.72 | Ascorbic Acid: a promising memory-enhancer in mice. ( Dhingra, D; Parle, M, 2003) |
| "Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex." | 3.67 | Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice. ( Forster, MJ; Lal, H; Popper, MD; Retz, KC, 1986) |
| " To determine whether age-related changes in alpha 1-acid glycoprotein influence drug binding in mother and newborn infant and also the effects of sex, pregnancy, and oral contraceptives on drug binding, the binding of lidocaine, diazepam, propranolol, d-tubocurarine, and metocurine was determined by equilibrium dialysis in 17 men, 16 nonpregnant women, 16 nonpregnant women on oral contraceptives, and 15 mothers and their newborn infants at delivery." | 3.66 | Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant. ( Wood, AJ; Wood, M, 1981) |
| "Published data on the effect of cirrhosis on diazepam pharmacokinetics were reanalyzed to determine how age, sex, and body weight might have influenced the conclusions." | 3.66 | Factors influencing diazepam pharmacokinetics: age, sex, and liver disease. ( Greenblatt, DJ; Harmatz, JS; Shader, RI, 1978) |
| "Age-related changes in disposition of diazepam and its principal active metabolite, desmethyldiazepam (DMDZ), during and after extended dosage with diazepam were studied in healthy volunteers." | 3.01 | Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly. ( Chen, Y; Greenblatt, DJ; Harmatz, JS; Shader, RI; Zhang, Q, 2021) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| "CSL also reversed successfully the memory deficits induced by scopolamine (0." | 1.37 | Reversal of memory deficits by Coriandrum sativum leaves in mice. ( Abdul Majeed, AB; Mani, V; Parle, M; Ramasamy, K, 2011) |
| "Factors likely to affect the pharmacokinetic disposition of diazepam in foals, such as body composition and hepatic enzyme activity, are in transition during the first 21 days of life." | 1.30 | Age-related changes in the pharmacokinetic disposition of diazepam in foals. ( Court, MH; Greenblatt, DJ; Norman, WM, 1997) |
| "When diazepam was given for sedative purpose in neonates and infants, the in-vivo urinary excretion of desmethyl diazepam, temazepam and oxazepam was extremely low in 1-2 day newborns (less than 5 nmol metabolites excreted in 24 h per kg body weight) and developed in the first week after birth." | 1.30 | Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. ( Cheron, G; Cresteil, T; Gueret, G; Sonnier, M; Treluyer, JM, 1997) |
| "Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e." | 1.29 | Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters. ( Löscher, W; Richter, A, 1993) |
| "For salicylic acid, n was 1." | 1.28 | Binding of diazepam, salicylic acid and digitoxin to albumin isolated from fetal and adult serum. ( Cappiello, M; Pacifici, GM; Viani, A, 1991) |
| " Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects." | 1.28 | Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990) |
| " Absolute bioavailability averaged 94%, indicating essentially complete absorption." | 1.27 | Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex. ( Divoll, M; Greenblatt, DJ; Ochs, HR; Shader, RI, 1983) |
| "3." | 1.27 | Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time. ( Niles, LP; Pickering, DS; Pulido, OM, 1988) |
| "Pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-HT in brain continued to remain high." | 1.27 | Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. ( Dey, PK; Sharma, HS, 1986) |
| "The diazepam stimuli were dose-dependent in each group." | 1.27 | A comparison of diazepam stimuli in aged and adult rats. ( Amrick, CL; Bennett, DA, 1987) |
| " Increases in pharmacologic effect that occur with aging may be caused by alterations in pharmacokinetic parameters or changes at the site of drug action." | 1.27 | Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats. ( Cooper, RL; Guthrie, S; Linnoila, M; Thurman, R, 1987) |
| " Increasing the intravenous dose of omeprazole from 10 mg to 40 mg had no significant effect on the pharmacokinetic parameters determined." | 1.27 | Pharmacokinetics and metabolism of omeprazole in man. ( Regårdh, CG, 1986) |
| "The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients." | 1.26 | [Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981) |
| " The terminal plasma half-life of diazepam ranged from 15." | 1.26 | The effect of age on the pharmacokinetics of diazepam. ( Barton, M; James, O; Macklon, AF; Rawlins, MD, 1980) |
| "Diazepam was metabolized by human foetal liver microsomes to N-desmethyldiazepam and N-methyloxazepam as early as the 13th week of gestation." | 1.26 | Dizepam metabolism in human foetal and adult liver. ( Ackermann, E; Richter, K, 1977) |
| " Despite the profound prolongation of t 1/2 (theta) with age, the constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary." | 1.25 | The effects of age and liver disease on the disposition and elimination of diazepam in adult man. ( Avant, GR; Hoyumpa, A; Klotz, U; Schenker, S; Wilkinson, GR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (51.91) | 18.7374 |
| 1990's | 31 (23.66) | 18.2507 |
| 2000's | 17 (12.98) | 29.6817 |
| 2010's | 14 (10.69) | 24.3611 |
| 2020's | 1 (0.76) | 2.80 |
| Authors | Studies |
|---|---|
| Greenblatt, DJ | 5 |
| Harmatz, JS | 2 |
| Zhang, Q | 1 |
| Chen, Y | 1 |
| Shader, RI | 3 |
| Nakayama, H | 1 |
| Abe, M | 1 |
| Morimoto, C | 1 |
| Iida, T | 1 |
| Okabe, S | 1 |
| Sakimura, K | 1 |
| Hashimoto, K | 1 |
| Matson, L | 1 |
| Dunn, E | 1 |
| Haines, K | 1 |
| Miller-Smith, S | 1 |
| Lee-Stubbs, R | 1 |
| Whitten, K | 1 |
| Ardinger, C | 1 |
| McCarren, H | 1 |
| McDonough, J | 1 |
| El-Hayek, YH | 1 |
| Wu, C | 1 |
| Ye, H | 1 |
| Wang, J | 1 |
| Carlen, PL | 1 |
| Zhang, L | 1 |
| Lee, CY | 1 |
| Liou, HH | 1 |
| Cueto-Escobedo, J | 1 |
| Contreras, CM | 1 |
| Bernal-Morales, B | 1 |
| Guillén-Ruiz, G | 1 |
| Rodríguez-Landa, JF | 1 |
| Koyanagi, T | 1 |
| Yamaura, Y | 1 |
| Yano, K | 1 |
| Kim, S | 1 |
| Yamazaki, H | 1 |
| Stodieck, SK | 1 |
| Greifzu, F | 1 |
| Goetze, B | 1 |
| Schmidt, KF | 1 |
| Löwel, S | 1 |
| Wakabayashi, C | 1 |
| Numakawa, T | 1 |
| Odaka, H | 1 |
| Ooshima, Y | 1 |
| Kiyama, Y | 1 |
| Manabe, T | 1 |
| Kunugi, H | 1 |
| Iwakura, Y | 1 |
| López-Granero, C | 1 |
| Ruiz-Muñoz, AM | 1 |
| Nieto-Escámez, FA | 1 |
| Colomina, MT | 1 |
| Aschner, M | 1 |
| Sánchez-Santed, F | 1 |
| Trezza, V | 1 |
| Baarendse, PJ | 1 |
| Vanderschuren, LJ | 1 |
| Mani, V | 1 |
| Parle, M | 3 |
| Ramasamy, K | 1 |
| Abdul Majeed, AB | 1 |
| Olvera-Hernández, S | 1 |
| Fernández-Guasti, A | 1 |
| Panhelainen, AE | 1 |
| Korpi, ER | 2 |
| Liu, L | 1 |
| Qian, XH | 1 |
| Feng, GD | 1 |
| Wu, MM | 1 |
| Yang, AA | 1 |
| Jiao, XY | 1 |
| You, SW | 1 |
| Ju, G | 1 |
| Mitchell, SJ | 1 |
| Huizer-Pajkos, A | 1 |
| Cogger, VC | 1 |
| McLachlan, AJ | 1 |
| Le Couteur, DG | 1 |
| Jones, B | 1 |
| de Cabo, R | 1 |
| Hilmer, SN | 1 |
| Cannizzaro, C | 1 |
| Martire, M | 1 |
| Cannizzaro, E | 1 |
| Monastero, R | 1 |
| Gagliano, M | 1 |
| Mineo, A | 1 |
| Provenzano, G | 1 |
| KANJILAL, GC | 1 |
| Dhingra, D | 1 |
| Echizenya, M | 2 |
| Mishima, K | 2 |
| Satoh, K | 2 |
| Kusanagi, H | 2 |
| Sekine, A | 1 |
| Ohkubo, T | 2 |
| Shimizu, T | 2 |
| Hishikawa, Y | 1 |
| Yasuda, K | 1 |
| Joshi, H | 1 |
| Tonkiss, J | 1 |
| Galler, J | 1 |
| Li, Y | 1 |
| Zhu, S | 1 |
| Hahn, RG | 1 |
| Jacobson-Pick, S | 1 |
| Elkobi, A | 1 |
| Vander, S | 1 |
| Rosenblum, K | 1 |
| Richter-Levin, G | 1 |
| Telang, S | 1 |
| Fuller, G | 1 |
| Wiggins, R | 1 |
| Enna, SJ | 1 |
| Vozeh, S | 1 |
| Saito, K | 1 |
| Goto, M | 1 |
| Fukuda, H | 1 |
| Aldinio, C | 1 |
| Balzano, M | 1 |
| Savoini, G | 2 |
| Leon, A | 1 |
| Toffano, G | 3 |
| Calderini, G | 2 |
| Bonetti, AC | 1 |
| Aldinio, A | 1 |
| Di Perri, B | 1 |
| Biggio, G | 2 |
| Tsang, CC | 1 |
| Speeg, KV | 1 |
| Wilkinson, GR | 3 |
| Guarneri, P | 1 |
| Corda, MG | 3 |
| Concas, A | 1 |
| Salis, M | 1 |
| Lal, H | 2 |
| Mann, P | 1 |
| Gianforcaro, R | 1 |
| Nandy, K | 1 |
| Acs, Z | 1 |
| Makara, GB | 1 |
| Stark, E | 1 |
| Meyer, BR | 1 |
| Morselli, PL | 2 |
| Franco-Morselli, R | 1 |
| Komiskey, HL | 4 |
| Cook, TM | 1 |
| Lin, CF | 1 |
| Hayton, WL | 1 |
| Cochrane, LA | 1 |
| Nicholson, AN | 1 |
| Stone, BM | 2 |
| Divoll, M | 1 |
| Ochs, HR | 1 |
| Ernst, K | 1 |
| Sung, SC | 1 |
| Saneyoshi, M | 1 |
| Clark, SM | 1 |
| Lipton, JM | 1 |
| Heusner, JE | 1 |
| Bosmann, HB | 1 |
| Nau, H | 1 |
| Liddiard, C | 1 |
| Macklon, AF | 1 |
| Barton, M | 1 |
| James, O | 1 |
| Rawlins, MD | 1 |
| Mayevsky, A | 1 |
| Shaya, B | 1 |
| Gersdorff, MC | 1 |
| Wood, M | 1 |
| Wood, AJ | 1 |
| Schroeder, H | 1 |
| Nolte, A | 1 |
| Boyet, S | 1 |
| Koziel, V | 1 |
| Nehlig, A | 1 |
| Giorgi, O | 2 |
| Cancedda, E | 2 |
| Lecca, D | 1 |
| Orlandi, M | 1 |
| Benesová, O | 1 |
| Tejkalová, H | 1 |
| Kristofiková, Z | 1 |
| Klaschka, J | 1 |
| Dostál, M | 1 |
| Aguayo, LG | 1 |
| Alarcón, JM | 1 |
| Richter, A | 1 |
| Löscher, W | 1 |
| Kellogg, CK | 2 |
| Taylor, MK | 1 |
| Rodriguez-Zafra, M | 2 |
| Pleger, GL | 2 |
| Uusi-Oukari, M | 1 |
| Kaivola, J | 1 |
| Yakushiji, T | 1 |
| Shirasaki, T | 1 |
| Munakata, M | 1 |
| Hirata, A | 1 |
| Akaike, N | 1 |
| Korkmaz, S | 1 |
| Carlsson, S | 1 |
| Wahlström, G | 1 |
| Pletnikov, MV | 1 |
| Storozheva, ZI | 1 |
| Sherstnev, VV | 1 |
| Meh, D | 1 |
| Denislic, M | 1 |
| McNamara, RK | 1 |
| Davis, TM | 1 |
| Skelton, RW | 1 |
| Obata, K | 1 |
| Norman, WM | 1 |
| Court, MH | 1 |
| Treluyer, JM | 1 |
| Gueret, G | 1 |
| Cheron, G | 1 |
| Sonnier, M | 1 |
| Cresteil, T | 1 |
| Paróczai, M | 1 |
| Kiss, B | 1 |
| Kárpáti, E | 1 |
| da Silva, LF | 1 |
| Pereira, P | 1 |
| Elisabetsky, E | 1 |
| Borde, N | 1 |
| Jaffard, R | 1 |
| Béracochéa, D | 1 |
| Puoliväli, J | 1 |
| Pradier, L | 1 |
| Riekkinen, P | 1 |
| Masuda, Y | 1 |
| Suzuki, M | 1 |
| Akagawa, Y | 1 |
| Takemura, T | 1 |
| Fukura, H | 1 |
| Kitani, Y | 1 |
| Komiya, Y | 1 |
| Igarashi, M | 1 |
| Taketo, M | 1 |
| Yoshioka, T | 1 |
| Fagiolini, M | 1 |
| Hensch, TK | 1 |
| Vanakoski, J | 1 |
| Mattila, MJ | 1 |
| Seppälä, T | 1 |
| Bazyan, AS | 1 |
| Zhulin, VV | 1 |
| Karpova, MN | 1 |
| Klishina, NY | 1 |
| Glebov, RN | 1 |
| Wikinski, SI | 1 |
| Acosta, GB | 1 |
| Gravielle, MC | 1 |
| Bonavita, CD | 1 |
| Bisagno, V | 1 |
| Fiszer de Plazas, S | 1 |
| Rubio, MC | 1 |
| Hevers, W | 1 |
| Lüddens, H | 1 |
| Chopin, P | 1 |
| Colpaert, FC | 1 |
| Marien, M | 1 |
| Hoyumpa, AM | 1 |
| Schenker, S | 2 |
| Kanto, J | 1 |
| Sellman, R | 1 |
| Haataja, M | 1 |
| Hurme, P | 1 |
| Klotz, U | 3 |
| Müller-Seydlitz, P | 1 |
| Giles, HG | 2 |
| MacLeod, SM | 2 |
| Wright, JR | 1 |
| Sellers, EM | 2 |
| Reidenberg, MM | 1 |
| Levy, M | 1 |
| Warner, H | 1 |
| Coutinho, CB | 1 |
| Schwartz, MA | 1 |
| Yu, G | 1 |
| Cheripko, J | 1 |
| Lippa, AS | 1 |
| Sano, MC | 1 |
| Coupet, J | 1 |
| Klepner, CA | 1 |
| Beer, B | 1 |
| Bengert, B | 1 |
| Liu, FF | 1 |
| Candy, JM | 1 |
| Martin, IL | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Ackermann, E | 1 |
| Richter, K | 1 |
| Avant, GR | 1 |
| Hoyumpa, A | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Viani, A | 2 |
| Rizzo, G | 1 |
| Carrai, M | 1 |
| Pacifici, GM | 2 |
| Jänicke, B | 2 |
| Coper, H | 2 |
| Fujita, S | 2 |
| Cappiello, M | 1 |
| Segovia, S | 1 |
| Pérez-Laso, C | 1 |
| Calés, JM | 1 |
| Del Abril, A | 1 |
| De Blas, MR | 1 |
| Collado, P | 1 |
| Valencia, A | 1 |
| Guillamón, A | 1 |
| Anschütz, F | 1 |
| Nicholson, PA | 1 |
| Karim, A | 1 |
| Smith, M | 1 |
| Gruen, RJ | 1 |
| Deutch, AY | 1 |
| Roth, RH | 1 |
| Caboche, J | 1 |
| Mitrovic, N | 1 |
| Le Saux, F | 1 |
| Besson, MJ | 1 |
| Sauter, A | 1 |
| Maurin, Y | 1 |
| Morimoto, R | 1 |
| Chiba, M | 1 |
| Kitani, K | 1 |
| Suzuki, T | 1 |
| Pomara, N | 2 |
| Deptula, D | 2 |
| Medel, M | 1 |
| Block, RI | 1 |
| Niles, LP | 1 |
| Pulido, OM | 1 |
| Pickering, DS | 1 |
| Raemont, LM | 1 |
| Mundinger, KL | 2 |
| Frieder, B | 1 |
| Grimm, VE | 1 |
| Bareggi, SR | 1 |
| Nielsen, NP | 1 |
| Leva, S | 1 |
| Pirola, R | 1 |
| Zecca, L | 1 |
| Lorini, M | 1 |
| Sharma, HS | 1 |
| Dey, PK | 1 |
| Shibuya, T | 1 |
| Watanabe, Y | 1 |
| Hill, HF | 1 |
| Salafsky, B | 1 |
| Sieghart, W | 1 |
| Hinrichs, JV | 1 |
| Ghoneim, MM | 1 |
| Amrick, CL | 1 |
| Bennett, DA | 1 |
| Buck, MA | 1 |
| McSweeney, FK | 1 |
| Farmer-Dougan, VA | 1 |
| Dougan, JD | 1 |
| Rubinstein, S | 1 |
| Stanley, B | 1 |
| Stanley, M | 1 |
| Schulze, G | 1 |
| Guthrie, S | 1 |
| Cooper, RL | 1 |
| Thurman, R | 1 |
| Linnoila, M | 1 |
| Regårdh, CG | 1 |
| Su, MQ | 1 |
| Yu, S | 1 |
| Leiter, JC | 1 |
| Knuth, SL | 1 |
| Krol, RC | 1 |
| Bartlett, D | 1 |
| Swift, CG | 1 |
| Ewen, JM | 1 |
| Clarke, P | 1 |
| Stevenson, IH | 1 |
| de Wit, H | 1 |
| Uhlenhuth, EH | 1 |
| Johanson, CE | 1 |
| Forster, MJ | 1 |
| Retz, KC | 1 |
| Popper, MD | 1 |
| Davis, D | 1 |
| Grossman, SH | 1 |
| Kitchell, BB | 1 |
| Shand, DG | 1 |
| Routledge, PA | 1 |
| Cromwell, HA | 1 |
5 reviews available for diazepam and Aging
| Article | Year |
|---|---|
[Benzodiazepine (clonazepam, nitrazepam, diazepam)].
Topics: Aging; Anticonvulsants; Biomarkers; Chromatography, Gas; Chromatography, High Pressure Liquid; Clona | 2004 |
Benzodiazepines in the elderly.
Topics: Adult; Aged; Aging; Benzodiazepines; Diazepam; Female; Flurazepam; Humans; Kinetics; Male; Middle Ag | 1982 |
Clinical pharmacokinetics of antiepileptic drugs in adults.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H | 1980 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
[Aging and drug metabolism: alteration of liver drug metabolizing ability in male rats. Is it functional deterioration or feminization of the liver?].
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Electron Transport; Female; Feminization; | 1991 |
9 trials available for diazepam and Aging
| Article | Year |
|---|---|
Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Diazepam; Female; Half-Life; Humans; Male; Metabolic Cleara | 2021 |
Dissociation between objective psychomotor impairment and subjective sleepiness after diazepam administration in the aged people.
Topics: Adolescent; Adult; Aged; Aging; Analysis of Variance; Attention; Central Nervous System Depressants; | 2007 |
Variability of response to hypnotics: sleep studies in man.
Topics: Adolescent; Adult; Aging; Diazepam; Humans; Hypnotics and Sedatives; Male; Middle Aged; Sleep; Sleep | 1983 |
Driving under light and dark conditions: effects of alcohol and diazepam in young and older subjects.
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Automobile Driving; Central Nervous System Depressants; Cro | 2000 |
Effects of diazepam on recall memory: relationship to aging, dose, and duration of treatment.
Topics: Adult; Aged; Aging; Diazepam; Female; Humans; Male; Memory Disorders; Middle Aged; Time Factors | 1989 |
Diazepam, behavior, and aging: increased sensitivity or lower baseline performance?
Topics: Adult; Aged; Aging; Animals; Behavior, Animal; Diazepam; Emotions; Female; Humans; Learning; Male; M | 1987 |
The effect of diazepam on genioglossal muscle activity in normal human subjects.
Topics: Adult; Aging; Carbon Dioxide; Diazepam; Double-Blind Method; Electromyography; Humans; Male; Middle | 1985 |
Drug preference in normal volunteers: effects of age and time of day.
Topics: Adult; Aging; Amphetamine; Diazepam; Drug Interactions; Emotions; Humans; Middle Aged; Reinforcement | 1985 |
Management of anxiety-depression in geriatric patients.
Topics: Adjustment Disorders; Aged; Aging; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Middle | 1973 |
117 other studies available for diazepam and Aging
| Article | Year |
|---|---|
Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum.
Topics: Aging; Animals; Animals, Newborn; Calcium; Calcium-Binding Proteins; Cell Communication; Cerebellum; | 2018 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
Hippocampal excitability is increased in aged mice.
Topics: Action Potentials; Age Factors; Aging; Animals; Biophysics; Brain Waves; Diazepam; Electric Stimulat | 2013 |
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop | 2013 |
Defensive burying test in postweaning rats: use of a small round chamber.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Fe | 2013 |
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Topics: Acetaminophen; Age Factors; Aging; Albumins; Animals; Antipyrine; Blood Proteins; Diazepam; Diphenhy | 2014 |
Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke.
Topics: Aging; Animals; Contrast Sensitivity; Darkness; Diazepam; Dominance, Ocular; Female; Male; Mice; Mic | 2014 |
IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Biogenic Monoamines; Diazepam; Hippocampus; Interleuki | 2015 |
Chronic dietary chlorpyrifos causes long-term spatial memory impairment and thigmotaxic behavior.
Topics: Aging; Animals; Anti-Anxiety Agents; Chlorpyrifos; Cholinesterase Inhibitors; Cues; Diazepam; Dizoci | 2016 |
Prosocial effects of nicotine and ethanol in adolescent rats through partially dissociable neurobehavioral mechanisms.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; | 2009 |
Reversal of memory deficits by Coriandrum sativum leaves in mice.
Topics: Aging; Animals; Anticholesteremic Agents; Avoidance Learning; Brain; Cholesterol; Cholinesterase Inh | 2011 |
Sex differences in the burying behavior test in middle-aged rats: effects of diazepam.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Electroshock; Estrous Cycl | 2011 |
Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study.
Topics: Aging; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dopaminergic Neurons; Gene Express | 2012 |
Different neuroprotection and therapeutic time windows by two specific diazepam regimens on retinal ganglion cells after optic nerve transection in adult rats.
Topics: Aging; Animals; Axotomy; Cell Count; Cell Survival; Diazepam; Female; Injections, Intraperitoneal; N | 2012 |
The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver.
Topics: Aging; Animals; Diazepam; Endothelium; Liver; Male; Perfusion; Poloxamer; Rats; Rats, Inbred F344; S | 2012 |
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze | 2003 |
A CLINICAL EVALUATION OF 'VALIUM' (RO5-2807) IN CEREBRAL PALSY.
Topics: Adolescent; Aging; Cerebral Palsy; Child; Diazepam; Physical Therapy Modalities; Toxicology; Tranqui | 1964 |
Ascorbic Acid: a promising memory-enhancer in mice.
Topics: Aging; Amnesia; Animals; Antioxidants; Anxiety; Ascorbic Acid; Avoidance Learning; Behavior, Animal; | 2003 |
Enhanced heat loss and age-related hypersensitivity to diazepam.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Analysis of Variance; Body Temperature Regulation; Cros | 2004 |
Nardostachys jatamansi improves learning and memory in mice.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Behavior, Animal; Diazepam; Female; Learning; Male; Maz | 2006 |
Prenatal malnutrition alters diazepam-mediated suppression of ultrasonic vocalizations in an age dependent manner.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Body Wei | 2007 |
The kinetics of Ringer's solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine.
Topics: Adult; Aged; Aging; Algorithms; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intr | 2007 |
Juvenile stress-induced alteration of maturation of the GABAA receptor alpha subunit in the rat.
Topics: Aging; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Azepines; Behavior, Animal; Blotting, Wester | 2008 |
Early undernutrition and [3H]gamma-aminobutyric acid binding in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Hippoca | 1984 |
[Pharmacokinetic of benzodiazepines in old age].
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M | 1981 |
Effects of pentobarbital on [3H]diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
Topics: Aging; Animals; Anti-Anxiety Agents; Cerebellum; Cerebral Cortex; Diazepam; Female; In Vitro Techniq | 1984 |
Ontogeny of 3H-diazepam binding sites in different rat brain area. Effect of GABA.
Topics: Aging; Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; gamma-Aminobutyric Acid; Rats; Rats | 1981 |
Functional interaction between benzodiazepine and GABA recognition sites in aged rats.
Topics: Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Diazepam; gamma-Aminobutyric Acid; Organ Spec | 1981 |
Aging and benzodiazepine binding in the rat cerebral cortex.
Topics: Aging; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Female; In Vitro Techniques; Rats; Rats, | 1982 |
Age-related changes of benzodiazepine and GABA binding sites in the rat retina.
Topics: Aging; Animals; Diazepam; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Recepto | 1982 |
Senescence related changes in brain diazepam binding and motor performance.
Topics: Aging; Animals; Cerebral Cortex; Diazepam; Mice; Motor Activity; Motor Skills; Receptors, Cell Surfa | 1982 |
Diazepam tolerance.
Topics: Adult; Aged; Aging; Biological Availability; Diazepam; Humans; Middle Aged | 1984 |
Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Diazepam; Female; GABA Antagonists; gamma-A | 1984 |
Impairment of learning or memory in the mature and old rat by diazepam.
Topics: Aging; Animals; Depression, Chemical; Diazepam; Female; Learning; Memory; Rats; Rats, Inbred F344 | 1981 |
Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex.
Topics: Administration, Oral; Adult; Aged; Aging; Biological Availability; Diazepam; Female; Humans; Injecti | 1983 |
[Psychiatric emergencies in general practice: medical and legal aspects (author's transl)].
Topics: Aged; Aging; Anxiety; Confidentiality; Diazepam; Emergency Services, Psychiatric; Forensic Psychiatr | 1982 |
Effect of synthetic purines and purine nucleosides on [3H]diazepam binding in brain.
Topics: Aging; Animals; Binding, Competitive; Brain; Diazepam; In Vitro Techniques; Male; Membranes; Purine | 1982 |
Effects of diazepam on body temperature of the aged squirrel monkey.
Topics: Aging; Animals; Body Temperature Regulation; Diazepam; Dose-Response Relationship, Drug; Injections, | 1981 |
GABA stimulation of 3H-diazepam binding in aged mice.
Topics: Aging; Animals; Brain; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Membr | 1981 |
Postnatal development of sex-dependent differences in the metabolism of diazepam by rat liver.
Topics: Aging; Animals; Biotransformation; Diazepam; Female; In Vitro Techniques; Kinetics; Liver; Male; Rat | 1980 |
The effect of age on the pharmacokinetics of diazepam.
Topics: Adolescent; Adult; Aged; Aging; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Pr | 1980 |
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobar | 1980 |
Dynamic study of the acoustico-facial reflex by impedance measurement.
Topics: Acoustic Impedance Tests; Aging; Auditory Fatigue; Diazepam; Epilepsy; Humans; Hyperacusis; Loudness | 1980 |
Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
Topics: Adult; Aging; Blood Proteins; Contraceptives, Oral; Diazepam; Female; Humans; Infant, Newborn; Lidoc | 1981 |
Short- and long-term effects of neonatal diazepam exposure on local cerebral glucose utilization in the rat.
Topics: Aging; Animals; Animals, Newborn; Brain; Diazepam; Energy Metabolism; Female; Glucose; Pharmaceutica | 1994 |
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compo | 1994 |
Early postnatal diazepam treatment of rats and neuroimmunocompetence in adulthood and senescence.
Topics: Aging; Animals; Behavior, Animal; Brain; Diazepam; Female; Immunocompetence; Male; Pregnancy; Rats; | 1994 |
Modulation of 35S-TBPS binding by GABAergic drugs in the cerebral cortex of newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, | 1993 |
Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol.
Topics: Aging; Animals; Barbiturates; Benzodiazepines; Bicuculline; Diazepam; Ethanol; GABA-A Receptor Antag | 1993 |
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
Topics: Aging; Aminooxyacetic Acid; Animals; Cricetinae; Diazepam; Dopamine Antagonists; Dystonia; Mesocrice | 1993 |
Altered stressor-induced changes in GABAA receptor function in the cerebral cortex of adult rats exposed in utero to diazepam.
Topics: Aging; Animals; Cerebral Cortex; Chlorides; Diazepam; Female; Male; Pregnancy; Prenatal Exposure Del | 1993 |
Postnatal development of diazepam-insensitive [3H]Ro 15-4513 binding sites.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Azides; Benzodiazepines; Brain; Brain Chemistry; C | 1993 |
Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones.
Topics: Aging; Animals; Benzothiepins; Central Nervous System; Cerebral Cortex; Diazepam; gamma-Aminobutyric | 1993 |
Maturation-related changes in tolerance development to hexobarbital after short term treatment with diazepam in the rat.
Topics: Aging; Animals; Diazepam; Drug Tolerance; Electroencephalography; Hexobarbital; Male; Rats; Rats, Sp | 1993 |
Relationship between memory and fear: developmental and pharmacological studies.
Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Diazepam; Fear; Female; Habituation, Psyc | 1996 |
Influence of age, temperature, sex, height and diazepam on vibration perception.
Topics: Adolescent; Adult; Aged; Aging; Body Height; Child; Diazepam; Female; Humans; Male; Middle Aged; Mot | 1995 |
Effect of aging on the spatial learning deficit produced by diazepam in rats.
Topics: Aging; Animals; Anti-Anxiety Agents; Cues; Diazepam; Dose-Response Relationship, Drug; Male; Maze Le | 1996 |
Excitatory and trophic action of GABA and related substances in newborn mice and organotypic cerebellar culture.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Calcium; Cell Count; Cerebellum; Diazepam; GABA Agent | 1997 |
Age-related changes in the pharmacokinetic disposition of diazepam in foals.
Topics: Adjuvants, Anesthesia; Aging; Animals; Diazepam; Female; Half-Life; Horses; Male; Metabolic Clearanc | 1997 |
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.
Topics: Adult; Aging; Child, Preschool; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Female; | 1997 |
Effect of RGH-2716 on learning and memory deficits of young and aged rats in water-labyrinth.
Topics: Aging; Amnesia, Retrograde; Animals; Diazepam; Learning Disabilities; Male; Maze Learning; Memory; M | 1998 |
A neuropharmacological analysis of PTZ-induced kindling in mice.
Topics: Aging; Animals; Anticonvulsants; Convulsants; Diazepam; Glutamic Acid; Kindling, Neurologic; Male; M | 1998 |
Effects of chronic alcohol consumption or Diazepam administration on item recognition and temporal ordering in a spatial working memory task in mice.
Topics: Aging; Alcohol Drinking; Animals; Diazepam; Male; Memory; Mice; Mice, Inbred BALB C; Time Factors | 1998 |
Moderate cortical EEG changes in apolipoprotein E-deficient mice during ageing and scopolamine treatment but not after nucleus basalis lesion.
Topics: Aging; Animals; Apolipoproteins E; Choline O-Acetyltransferase; Diazepam; Electroencephalography; Ma | 1999 |
Developmental and pharmacological features of mouse emotional piloerection.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Behavior, Animal; Conditioning, Classical; Diazepam; E | 1999 |
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob | 1999 |
Developmental change of GABA(A) receptor-mediated current in rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Diazepam; Electric Conductivity; Electric Stimulation; GABA Antago | 2000 |
Inhibitory threshold for critical-period activation in primary visual cortex.
Topics: Aging; Animals; Critical Period, Psychological; Diazepam; gamma-Aminobutyric Acid; Haplorhini; Mice; | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil | 2001 |
Diazepam fails to potentiate GABA-induced chloride uptake and to produce anxiolytic-like action in aged rats.
Topics: Aging; Animals; Anti-Anxiety Agents; Cerebral Cortex; Chlorides; Diazepam; Dose-Response Relationshi | 2001 |
Pharmacological heterogeneity of gamma-aminobutyric acid receptors during development suggests distinct classes of rat cerebellar granule cells in situ.
Topics: Aging; Algorithms; Animals; Bicuculline; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; E | 2002 |
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Ag | 2002 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H | 1978 |
Diazepam and its hydroxylated metabolites: studies on sleep in healthy man.
Topics: Adult; Aging; Diazepam; Humans; Hydroxylation; Male; Middle Aged; Oxazepam; Sleep; Sleep, REM; Temaz | 1979 |
Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
Topics: Adult; Aging; Biotransformation; Child; Creatinine; Diazepam; Female; Humans; Infant; Infant, Newbor | 1978 |
Altered elimination of desmethyldiazepam in the elderly.
Topics: Adult; Aged; Aging; Diazepam; Half-Life; Humans; Liver; Nordazepam; Time Factors | 1979 |
Effect of age on levels of diazepam in plasma and brain of rats.
Topics: Aging; Animals; Brain Chemistry; Cerebellum; Diazepam; Half-Life; Male; Rats; Time Factors | 1979 |
Influence of age and previous use of diazepam dosage required for endoscopy.
Topics: Adult; Aged; Aging; Body Surface Area; Diazepam; Endoscopy; Female; Humans; Injections, Intravenous; | 1978 |
Relationship between diazepam dose, plasma level, age, and central nervous system depression.
Topics: Adult; Aged; Aging; Central Nervous System; Depression, Chemical; Diazepam; Dose-Response Relationsh | 1978 |
Factors influencing diazepam pharmacokinetics: age, sex, and liver disease.
Topics: Adult; Aged; Aging; Body Weight; Diazepam; Female; Galactose; Humans; Kinetics; Liver Diseases; Male | 1978 |
Evidence that benzodiazepine receptors reside on cerebellar purkinje cells: studies with "nervous" mutant mice.
Topics: Aging; Animals; Benzodiazepines; Diazepam; Male; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; P | 1978 |
Age- and gender-related differences in diazepam pharmacokinetics.
Topics: Adult; Aged; Aging; Diazepam; Female; Half-Life; Humans; Kinetics; Male; Sex Factors | 1979 |
The postnatal development of the benzodiazepine receptor in the cerebral cortex and cerebellum of the rat.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cerebral Cortex; Diazepam; Female; Kinetics; Male; Org | 1979 |
Dizepam metabolism in human foetal and adult liver.
Topics: Aging; Carbon Monoxide; Dealkylation; Depression, Chemical; Diazepam; Female; Fetus; Gestational Age | 1977 |
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aging; Alcoholism; Animals; Diazepam; Fe | 1975 |
Proceedings: Drug disposition during development.
Topics: Aging; Child Development; Child, Preschool; Diazepam; Half-Life; Humans; Infant; Infant, Newborn; Ph | 1974 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
The effect of ageing on plasma albumin and plasma protein binding of diazepam, salicylic acid and digitoxin in healthy subjects and patients with renal impairment.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Proteins; Diazepam; Digitoxin; Humans; Kidn | 1992 |
Effects of age and drugs on food and fluid intake.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Diazepam; Drinking; Dr | 1991 |
Binding of diazepam, salicylic acid and digitoxin to albumin isolated from fetal and adult serum.
Topics: Adult; Aging; Binding Sites; Diazepam; Digitoxin; Fetus; Humans; Salicylates; Salicylic Acid; Serum | 1991 |
Early postnatal diazepam exposure alters sex differences in the rat brain.
Topics: Aging; Animals; Body Weight; Brain; Diazepam; Female; Locus Coeruleus; Male; Neurons; Olfactory Bulb | 1991 |
[Physiological changes of organs in old age].
Topics: Aged; Aging; Diazepam; Humans; Mental Processes; Metabolic Clearance Rate; Morbidity; Pharmaceutical | 1991 |
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug | 1990 |
Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover.
Topics: Aging; Animals; Brain; Diazepam; Dopamine; Exploratory Behavior; Female; Male; Pregnancy; Prenatal E | 1990 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm | 1989 |
Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Diazepam; Female; Imipramine; Immunologic Techniques | 1989 |
GABA-stimulated chloride uptake and enhancement by diazepam in synaptoneurosomes from rat brain during prenatal and postnatal development.
Topics: Aging; Animals; Brain; Chlorides; Diazepam; Fetus; gamma-Aminobutyric Acid; Rats; Synaptosomes | 1989 |
Age-related changes in GABA and benzodiazepine receptor binding in rat brain are influenced by sampling time.
Topics: Aging; Animals; Brain; Cerebral Cortex; Circadian Rhythm; Diazepam; gamma-Aminobutyric Acid; Kinetic | 1988 |
Aging: modulation of GABAA binding sites by ethanol and diazepam.
Topics: Aging; Animals; Brain; Diazepam; Ethanol; Kinetics; Male; Rats; Rats, Inbred F344; Receptors, GABA-A | 1988 |
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus | 1985 |
Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam).
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Diazepam; Female; Human | 1986 |
Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection.
Topics: Aging; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Diazepam; Flunitrazepam; Kinetics; | 1987 |
Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.
Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Cyproheptadine; Diazepam; Fem | 1986 |
Developmental alterations in maturing rats caused by chronic prenatal and postnatal diazepam treatments.
Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Female; Male; Pre | 1986 |
Comparison of benzodiazepine receptors in cerebellum and inferior colliculus.
Topics: Aging; Animals; Animals, Newborn; Carbolines; Cell Membrane; Cerebellum; Clonazepam; Diazepam; Fluni | 1986 |
A comparison of diazepam stimuli in aged and adult rats.
Topics: Aging; Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Dru | 1987 |
Effect of aging on anticonflict and CNS depressant activity of diazepam in rats.
Topics: Aging; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Conflic | 1987 |
The effects of diazepam and aging on intrusions.
Topics: Adult; Aged; Aging; Diazepam; Female; Humans; Male; Middle Aged; Psychomotor Performance | 1988 |
Adaptivity as a paradigm for age-dependent changes exemplified by motor behavior.
Topics: Adaptation, Physiological; Aging; Animals; Diazepam; Hypoxia; Motor Activity; Time Factors | 1988 |
Pharmacodynamics and pharmacokinetics of ethanol, diazepam and pentobarbital in young and aged rats.
Topics: Aging; Animals; Brain Chemistry; Diazepam; Ethanol; Female; Pentobarbital; Rats; Sleep | 1987 |
Pharmacokinetics and metabolism of omeprazole in man.
Topics: Administration, Oral; Aged; Aging; Anti-Ulcer Agents; Benzimidazoles; Diazepam; Dose-Response Relati | 1986 |
Maternal diazepam exposure on brain ornithine decarboxylase and growth of offspring.
Topics: Aging; Animals; Brain; Carbon Radioisotopes; Diazepam; Female; Maternal-Fetal Exchange; Ornithine De | 1986 |
Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations.
Topics: Adult; Aged; Aging; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedati | 1985 |
Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice.
Topics: Aging; Animals; Ataxia; Barbiturates; Body Weight; Diazepam; Dose-Response Relationship, Drug; Male; | 1986 |
The effects of age and smoking on the plasma protein binding of lignocaine and diazepam.
Topics: Adolescent; Adult; Aged; Aging; Diazepam; Female; Humans; Lidocaine; Male; Middle Aged; Orosomucoid; | 1985 |