diazepam and Adverse Drug Event studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"Diazepam was administered to seven severely affected athetoid children for a period of two to three months to determine whether beneficial effects could be demonstrated from its use."	5.24	DIAZEPAM: A PRELIMINARY STUDY OF ITS EFFECTS ON PATIENTS WITH ATHETOID CEREBRAL PALSY. ( ANGARA, VS; WHITTAKER, JS, 1965)
" Diazepam (Valium) could cause cleft palate by mimicking GABA."	3.67	Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development. ( Zimmerman, EF, 1984)
" This study evaluated the safety profile and recommended phase II dosing of apatorsen in patients with advanced cancer."	2.82	A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers. ( Bazov, J; Chi, KN; Gleave, ME; Higano, CS; Hotte, SJ; Jacobs, C; Kollmannsberger, C; Mukherjee, SD; Stewart, PS; Yu, EY, 2016)
"Nausea and vomiting are frequent and unpleasant side effects of cancer chemotherapy."	2.36	[Nausea and vomiting during chemotherapy of malignant tumors]. ( Brunner, KW; Galeazzi, R; Gervasi, A; Godat, F; Goldhirsch, A; Joss, R, 1981)
"Case note review of 278 children with dystonia referred to our service."	1.43	Medication use in childhood dystonia. ( Kaminska, M; Lin, JP; Lumsden, DE; Tomlin, S, 2016)
"Propofol is an addictive drug, and the problem of its abuse and dependence has occurred."	1.42	Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. ( Kim, MH; Park, BJ; Park, HJ; Shin, JY, 2015)
" We calculated rates of adverse events according to benzodiazepine use and identified risk factors for complications using univariate and multivariate analyses."	1.39	Safety of midazolam for sedation of HIV-positive patients undergoing colonoscopy. ( Arpino, P; Backman, ES; Ehrenfeld, JM; Gandhi, RT; Losina, E; Lu, Z; Triant, VA, 2013)
"Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids."	1.38	In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012)
"5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects."	1.32	Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004)
"Diazepam was found in 16 of the 18 subjects in whom psychotropic drugs were detected."	1.26	Role of drugs in traffic accidents. ( Alha, A; Ertama, L; Honkanen, R; Karlsson, M; Kiviluoto, O; Linnoila, M; Lukkari, I; Puro, M, 1980)
" Clinicians are encouraged to report possible adverse drug reactions to the National Registry of Drug-Induced Ocular Side Effects, which has been moved to the Department of Ophthalmology, University of Oregon Health Sciences Center, Portland, OR 97201."	1.26	Interim report: National Registry of Possible Drug-Induced Ocular Side Effects. ( Fraunfelder, FT, 1979)
"Diazepam was administered to seven severely affected athetoid children for a period of two to three months to determine whether beneficial effects could be demonstrated from its use."	1.24	DIAZEPAM: A PRELIMINARY STUDY OF ITS EFFECTS ON PATIENTS WITH ATHETOID CEREBRAL PALSY. ( ANGARA, VS; WHITTAKER, JS, 1965)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (58.33)	18.7374
1990's	2 (5.56)	18.2507
2000's	2 (5.56)	29.6817
2010's	9 (25.00)	24.3611
2020's	2 (5.56)	2.80

Authors	Studies
Matthews, EJ	1
Kruhlak, NL	1
Weaver, JL	1
Benz, RD	1
Contrera, JF	1
Fischer, H	1
Atzpodien, EA	1
Csato, M	1
Doessegger, L	1
Lenz, B	1
Schmitt, G	1
Singer, T	1
Liu, Z	1
Shi, Q	1
Ding, D	1
Kelly, R	1
Fang, H	1
Tong, W	1
Morgan, RE	1
van Staden, CJ	1
Chen, Y	1
Kalyanaraman, N	1
Kalanzi, J	1
Dunn, RT	1
Afshari, CA	1
Hamadeh, HK	1
Nimmaanrat, S	1
Charuenporn, B	1
Jensen, MP	1
Geater, AF	1
Tanasansuttiporn, J	1
Chanchayanon, T	1
Chai, PR	1
Ferro, EG	1
Kirshenbaum, JM	1
Hayes, BD	1
Culbreth, SE	1
Boyer, EW	1
Erickson, TB	1
Pessoa, TL	1
Clemente Junior, WS	1
Costa, TXD	1
Bezerra, PKDV	1
Martins, RR	1
Park, HJ	1
Shin, JY	1
Kim, MH	1
Park, BJ	1
Lumsden, DE	1
Kaminska, M	1
Tomlin, S	1
Lin, JP	1
Chi, KN	1
Yu, EY	1
Jacobs, C	1
Bazov, J	1
Kollmannsberger, C	1
Higano, CS	1
Mukherjee, SD	1
Gleave, ME	1
Stewart, PS	1
Hotte, SJ	1
Avcil, M	1
Kapçı, M	1
Yavaşoğlu, I	1
Kantekin, B	1
Akpek, M	1
Backman, ES	1
Triant, VA	1
Ehrenfeld, JM	1
Lu, Z	1
Arpino, P	1
Losina, E	1
Gandhi, RT	1
ANGARA, VS	1
WHITTAKER, JS	1
Briem, S	1
Martinsson, S	1
Bueters, T	1
Skoglund, E	1
Joss, R	1
Galeazzi, R	1
Gervasi, A	1
Godat, F	1
Goldhirsch, A	1
Brunner, KW	1
Zimmerman, EF	1
Hill, LM	1
Kleinberg, F	1
Bryant, SG	1
Honkanen, R	1
Ertama, L	1
Linnoila, M	1
Alha, A	1
Lukkari, I	1
Karlsson, M	1
Kiviluoto, O	1
Puro, M	1
Johansson, K	1
Bryding, G	1
Dahl, ML	1
Holmgren, P	1
Viitanen, M	1
Levine, L	1
Windorfer, A	1
Stünkel, S	1
Fraunfelder, FT	1
Dengler, HJ	1
Eichelbaum, M	1
Vaisman, SL	1
Gartner, LM	1
Saxén, I	1
Silbermann, RM	1
Boer, F	1
Janssen, F	1
Kaempe, BP	1
Katsulov, A	1
Brahams, D	1
Wilson, D	1
Parsonage, M	1
Trieger, N	1
Lien, EJ	1
Gudauskas, GA	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Phase 1 Study Evaluating A Second Generation Antisense Oligonucleotide (OGX 427) That Inhibits Heat Shock Protein 27 (Hsp27[NCT00487786]			Phase 1	64 participants (Actual)	Interventional	2007-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Nausea and vomiting during chemotherapy of malignant tumors]. Schweizerische medizinische Wochenschrift, 1981, Oct-24, Volume: 111, Issue:43 Topics: Antiemetics; Antipsychotic Agents; Diazepam; Drug-Related Side Effects and Adverse Reactions; Histam	1981
Effects of drugs and chemicals on the fetus and newborn (2). Mayo Clinic proceedings, 1984, Volume: 59, Issue:11 Topics: Abnormalities, Drug-Induced; Anticoagulants; Anticonvulsants; Diazepam; Drug-Related Side Effects an	1984
Reported ocular side effects of the ten most frequently prescribed drugs. Journal of the American Optometric Association, 1979, Volume: 50, Issue:2 Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Rel	1979
Pharmacologic treatment of neonatal hyperbilirubinemia. Clinics in perinatology, 1975, Volume: 2, Issue:1 Topics: Adolescent; Animals; Aspartic Acid; Bilirubin; DDT; Diazepam; Drug Therapy, Combination; Drug-Relate	1975
[Harmful effects of drugs used in treating late toxicoses]. Akusherstvo i ginekologiia, 1986, Volume: 25, Issue:1 Topics: Adrenergic beta-Antagonists; Breast Feeding; Diazepam; Diuretics; Dose-Response Relationship, Drug;	1986

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru	2004
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse	2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology, 2011, Volume: 7, Issue:12 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily	2013
Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam: an Increasing Concern in the COVID-19 Pandemic. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2020, Volume: 16, Issue:3 Topics: Adult; Coronavirus Infections; COVID-19; Diazepam; Drug Overdose; Drug-Related Side Effects and Adve	2020
Drug interactions in maternal intensive care: prevalence, risk factors, and potential risk medications. Einstein (Sao Paulo, Brazil), 2019, May-30, Volume: 17, Issue:3 Topics: Adolescent; Adult; Brazil; Cross-Sectional Studies; Diazepam; Drug Interactions; Drug-Related Side E	2019
Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. Regulatory toxicology and pharmacology : RTP, 2015, Volume: 71, Issue:3 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anesthetics, Intravenous; Child; C	2015
Medication use in childhood dystonia. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016, Volume: 20, Issue:4 Topics: Adolescent; Antiparkinson Agents; Baclofen; Child; Chloral Hydrate; Cohort Studies; Diazepam; Drug-R	2016
Simultaneous Use of Intravenous Lipid Emulsion and Plasma Exchange Therapies in Multiple Drug Toxicity. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2016, Volume: 25, Issue:6 Topics: Amisulpride; Antihypertensive Agents; Antipsychotic Agents; Aripiprazole; Diazepam; Drug-Related Sid	2016
Safety of midazolam for sedation of HIV-positive patients undergoing colonoscopy. HIV medicine, 2013, Volume: 14, Issue:6 Topics: Adult; Anesthetics, Intravenous; Colonoscopy; Diazepam; Drug-Related Side Effects and Adverse Reacti	2013
DIAZEPAM: A PRELIMINARY STUDY OF ITS EFFECTS ON PATIENTS WITH ATHETOID CEREBRAL PALSY. Canadian Medical Association journal, 1965, Aug-21, Volume: 93 Topics: Adolescent; Athetosis; Cerebral Palsy; Child; Conduct Disorder; Diazepam; Drug Therapy; Drug-Related	1965
Combined approach for high-throughput preparation and analysis of plasma samples from exposure studies. Rapid communications in mass spectrometry : RCM, 2007, Volume: 21, Issue:13 Topics: Animals; Anti-Anxiety Agents; Chromatography, Liquid; Computer Simulation; Diazepam; Drug Evaluation	2007
Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development. American journal of mental deficiency, 1984, Volume: 88, Issue:5 Topics: Abnormalities, Drug-Induced; Acetylcholine; Animals; Cell Movement; Cleft Palate; Diazepam; Dopamine	1984
Street drug misrepresentation. JAMA, 1980, Nov-14, Volume: 244, Issue:19 Topics: Adult; Diazepam; Drug-Related Side Effects and Adverse Reactions; Dystonia; Haloperidol; Humans; Ill	1980
Role of drugs in traffic accidents. British medical journal, 1980, Nov-15, Volume: 281, Issue:6251 Topics: Accidents, Traffic; Alcohol Drinking; Diazepam; Drug-Related Side Effects and Adverse Reactions; Fin	1980
Traffic dangerous drugs are often found in fatally injured older male drivers. Journal of the American Geriatrics Society, 1997, Volume: 45, Issue:8 Topics: Accidents, Traffic; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic;	1997
[Significance of pharmacogenic liver reactions for metabolism of endogenous and exogenous substances]. Monatsschrift fur Kinderheilkunde, 1979, Volume: 127, Issue:3 Topics: Carbamazepine; Diazepam; Drug-Related Side Effects and Adverse Reactions; Female; Fenoterol; Humans;	1979
Interim report: National Registry of Possible Drug-Induced Ocular Side Effects. Ophthalmology, 1979, Volume: 86, Issue:1 Topics: Aged; Anesthetics, Local; Carbonic Anhydrase Inhibitors; Cardiovascular Diseases; Diazepam; Dietary	1979
[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)]. Arzneimittel-Forschung, 1977, Volume: 27, Issue:96 Topics: Animals; Antipyrine; Cyclacillin; Diazepam; Drug-Related Side Effects and Adverse Reactions; Humans;	1977
Associations between oral clefts and drugs taken during pregnancy. International journal of epidemiology, 1975, Volume: 4, Issue:1 Topics: Abnormalities, Drug-Induced; Analgesics; Anticonvulsants; Chloramphenicol; Cleft Lip; Cleft Palate;	1975
[A life-threatening psychosis]. Nederlands tijdschrift voor geneeskunde, 1975, May-03, Volume: 119, Issue:18 Topics: Acute Disease; Delirium; Dexamethasone; Diazepam; Drug Interactions; Drug-Related Side Effects and A	1975
[Diseases caused by drug therapy in newborn babies]. Monatsschrift fur Kinderheilkunde, 1975, Volume: 123, Issue:1 Topics: Apgar Score; Diazepam; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; H	1975
[Traffic chemistry--seen in the rear-view mirror]. Ugeskrift for laeger, 1992, Jan-27, Volume: 154, Issue:5 Topics: Accidents, Traffic; Automobile Driving; Denmark; Diazepam; Drug-Related Side Effects and Adverse Rea	1992
Iatrogenic crime: criminal behaviour in patients receiving drug treatment. Lancet (London, England), 1987, Apr-11, Volume: 1, Issue:8537 Topics: Accidents, Traffic; Adult; Behavior; Crime; Diazepam; Drug-Related Side Effects and Adverse Reaction	1987
Experience with drugs and driving in Queensland, Australia. Medicine, science, and the law, 1985, Volume: 25, Issue:1 Topics: Australia; Automobile Driving; Diazepam; Diphenhydramine; Drug Interactions; Drug-Related Side Effec	1985
Psychiatric side effects of nonpsychiatric drugs. Seminars in psychiatry, 1971, Volume: 3, Issue:4 Topics: Aminophylline; Analgesics; Anti-Anxiety Agents; Anti-Bacterial Agents; Anticonvulsants; Antiemetics;	1971
Epilepsy. The Practitioner, 1974, Volume: 213, Issue:1276 SPEC Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec	1974
Intravenous sedation. Dental clinics of North America, 1973, Volume: 17, Issue:2 Topics: Comprehensive Dental Care; Dental Care; Diazepam; Drug-Related Side Effects and Adverse Reactions; H	1973
Structure side-effect sorting of drugs. I. Extrapyramidal syndrome. Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:4 Topics: Anticonvulsants; Basal Ganglia Diseases; Benzamides; Computers; Diazepam; Drug-Related Side Effects	1973

diazepam and Adverse Drug Event

Research Excerpts

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies