diazepam has been researched along with Acute Brain Injuries in 30 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " To determine if immediate post-traumatic events such as seizures may activate Rho, we examined RhoA activation in the brains of rats with kainic acid-induced seizures." | 3.73 | Activation of Rho after traumatic brain injury and seizure in rats. ( Deschamps, K; Dubreuil, CI; Marklund, N; McIntosh, TK; McKerracher, L, 2006) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Rats treated with diazepam did not differ in mortality from injured rats treated with vehicle." | 1.31 | Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats. ( DeFord, SM; Gibson, CJ; Hamm, RJ; O'Dell, DM; Wilson, MS, 2000) |
| "Diazepam pre-treatment did not restore the expression of amphetamine CPP." | 1.31 | Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference. ( Franklin, KB; Leri, F, 2000) |
| "Cerebral edema is responsible for intracranial hypertension and tentorial herniation, which in turn increase edema through venous compression, ischemia, and hypoxia." | 1.27 | [Post-traumatic cerebral edema. Physiopathology and treatment]. ( Jomin, M; Lesoin, F; Lozes, G; Verier, A, 1984) |
| "When diazepam was given 5 min after each convulsion it still had the same effect, although its effects on the ECS-induced changes was blocked by administration of the specific benzodiazepine antagonist Ro 15-1788 (10 mg/kg IP) at the same time as diazepam." | 1.27 | Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment. ( Green, AR; Mountford, JA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (46.67) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mrad, Y | 1 |
| El Jammal, R | 1 |
| Hajjar, H | 1 |
| Alturk, S | 1 |
| Salah, H | 1 |
| Chehade, HD | 1 |
| Dandash, F | 1 |
| Mallah, Z | 1 |
| Kobeissy, F | 1 |
| Habib, A | 1 |
| Hamade, E | 1 |
| Obeid, M | 1 |
| Rojas, A | 1 |
| Wang, J | 1 |
| Glover, A | 1 |
| Dingledine, R | 1 |
| Reddy, DS | 1 |
| Zaayman, M | 1 |
| Kuruba, R | 1 |
| Wu, X | 1 |
| Villasana, LE | 1 |
| Peters, A | 1 |
| McCallum, R | 1 |
| Liu, C | 1 |
| Schnell, E | 1 |
| Biagini, G | 1 |
| Baldelli, E | 1 |
| Longo, D | 1 |
| Contri, MB | 1 |
| Guerrini, U | 1 |
| Sironi, L | 1 |
| Gelosa, P | 1 |
| Zini, I | 1 |
| Ragsdale, DS | 1 |
| Avoli, M | 1 |
| Mtchedlishvili, Z | 1 |
| Lepsveridze, E | 1 |
| Xu, H | 1 |
| Kharlamov, EA | 1 |
| Lu, B | 1 |
| Kelly, KM | 1 |
| Gibson, CJ | 2 |
| Meyer, RC | 1 |
| Hamm, RJ | 2 |
| CANAL, N | 1 |
| Arciniegas, DB | 1 |
| Frey, KL | 1 |
| Anderson, CA | 1 |
| Brousseau, KM | 1 |
| Harris, SN | 1 |
| Nakamura, A | 1 |
| Naito, H | 1 |
| Inoue, M | 1 |
| Masaoka, T | 1 |
| Statler, KD | 1 |
| Alexander, H | 1 |
| Vagni, V | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Jenkins, L | 1 |
| Kochanek, PM | 1 |
| Dubreuil, CI | 1 |
| Marklund, N | 1 |
| Deschamps, K | 1 |
| McIntosh, TK | 1 |
| McKerracher, L | 1 |
| Verier, A | 1 |
| Jomin, M | 1 |
| Lozes, G | 1 |
| Lesoin, F | 1 |
| Melnic, L | 1 |
| Caradoc-Davies, TH | 1 |
| O'Dell, DM | 1 |
| Wilson, MS | 1 |
| DeFord, SM | 1 |
| Leri, F | 1 |
| Franklin, KB | 1 |
| Temkin, NR | 1 |
| Escuret, E | 1 |
| Roquefeuil, B | 1 |
| Frerebeau, P | 1 |
| Baldy-Moulinier, M | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Iasnetsov, VS | 1 |
| Novikov, VE | 1 |
| Green, AR | 1 |
| Mountford, JA | 1 |
| Schallert, T | 1 |
| Hernandez, TD | 1 |
| Barth, TM | 1 |
| Dahlberg, PJ | 1 |
| Cogbill, TH | 1 |
| Annis, BL | 1 |
| Deering, WM | 1 |
| Ferngren, HG | 1 |
| Ouellette, EM | 1 |
| Soulairac, A | 1 |
| Baron, JB | 1 |
| Langevin, P | 1 |
| Weber, M | 1 |
| Masingue, M | 1 |
| Martin, JY | 1 |
| Tridon, P | 1 |
| Arnould, G | 1 |
| Frowein, RA | 1 |
| Karimi-Nejad, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazepam and Acute Brain Injuries
| Article | Year |
|---|---|
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
28 other studies available for diazepam and Acute Brain Injuries
| Article | Year |
|---|---|
Lestaurtinib (CEP-701) reduces the duration of limbic status epilepticus in periadolescent rats.
Topics: Animals; Brain Injuries; Child; Diazepam; Furans; Hippocampus; Humans; Rats; Status Epilepticus | 2023 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.
Topics: Animals; Brain Injuries; Cell Movement; Cell Proliferation; Cell Shape; Dendrites; Diazepam; Disease | 2019 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A | 2010 |
Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus.
Topics: Animals; Blotting, Western; Brain Injuries; Calcium Channel Blockers; Calcium Signaling; Chlorides; | 2010 |
[CLINICAL EXPERIENCES WITH A NEW DRUG OF THE BENZODIAZEPINE SERIES: METHYLDIAZEPINONE].
Topics: Anxiety; Anxiety Disorders; Benzodiazepines; Brain Injuries; Depression; Diazepam; Humans; Mental Di | 1963 |
Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy.
Topics: Adult; Amantadine; Brain; Brain Injuries; Cognition Disorders; Demyelinating Diseases; Diazepam; Dop | 2004 |
Neonatal cerebral cortical lesion abolishes the anxiolytic action of diazepam in adult rats: effects of location and extent of cortical lesion.
Topics: Air; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Brain Injuries; Diazepam; Electroshock | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug In | 2006 |
[Post-traumatic cerebral edema. Physiopathology and treatment].
Topics: Alfaxalone Alfadolone Mixture; Barbiturates; Brain Edema; Brain Injuries; Cytidine Diphosphate Choli | 1984 |
[Use of sedatives in seriously ill patients with cerebral neurosurgical disorders].
Topics: Adolescent; Adult; Aged; Brain Diseases; Brain Injuries; Child; Child, Preschool; Diazepam; Female; | 1983 |
Traumatic mutism in severe head injury relieved by oral diazepam.
Topics: Adult; Brain Injuries; Diazepam; Female; Humans; Muscle Relaxants, Central; Mutism | 1996 |
Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats.
Topics: Animals; Bicuculline; Brain Injuries; Cognition; Diazepam; GABA Antagonists; GABA Modulators; Male; | 2000 |
Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference.
Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain Injuries; Central Ne | 2000 |
Effect of hyperventilation associated with administration of central nervous depressants in brain injuries.
Topics: Brain; Brain Injuries; Cerebrovascular Circulation; Diazepam; Humans; Hyperventilation; Phenobarbita | 1977 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
[The GABA-ergic system and brain edema].
Topics: Animals; Anti-Anxiety Agents; Benactyzine; Benzodiazepines; Benzodiazepinones; Brain Edema; Brain In | 1985 |
Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment.
Topics: Animals; Brain; Brain Injuries; Diazepam; Electric Injuries; Mice; Mice, Inbred C57BL; Receptors, Ad | 1985 |
Recovery of function after brain damage: severe and chronic disruption by diazepam.
Topics: Animals; Brain Injuries; Diazepam; Functional Laterality; Male; Nerve Crush; Nerve Regeneration; Neu | 1986 |
Malignant posttraumatic hypermetabolic syndrome associated with brain injury.
Topics: Adolescent; Adult; Brain Injuries; Diazepam; Female; Humans; Male; Metabolic Diseases; Muscle Contra | 1985 |
Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.
Topics: Adolescent; Age Factors; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Diazepam; E | 1974 |
[Statokinesimetric study of postural regulation in man (normal and pathologic variations)].
Topics: Brain Injuries; Diazepam; Humans; Posture; Succinates | 1967 |
[Convulsions in children].
Topics: Adolescent; Adult; Anticonvulsants; Birth Injuries; Brain Diseases; Brain Injuries; Child; Child, Pr | 1973 |
[Diagnostic value of the reactivity of E.E.G. foci to diazepam injection. (Statistical study of 327 cases)].
Topics: Adolescent; Adult; Aged; Brain Abscess; Brain Damage, Chronic; Brain Diseases; Brain Edema; Brain In | 1973 |
[Intensive therapy in craniocerebral injuries].
Topics: Adolescent; Adult; Aged; Brain Injuries; Child; Child, Preschool; Craniocerebral Trauma; Diazepam; H | 1969 |