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diazepam and Acidosis

diazepam has been researched along with Acidosis in 22 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
"This study compared acid-base and biochemical changes and quality of recovery in male cats with experimentally induced urethral obstruction and anesthetized with either propofol or a combination of ketamine and diazepam for urethral catheterization."9.16Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam. ( Carregaro, AB; da Cunha, JP; da Cunha, MG; Freitas, GC; Gomes, K; Pippi, NL; Togni, M, 2012)
" Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma."7.73Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005)
"Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication."7.67Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984)
"A patient with tetanus was treated with high-dose intravenous (IV) diazepam for control of muscular spasms."7.66Induction of lactic acidosis with intravenous diazepam in a patient with tetanus. ( Carey, P; Kapoor, W; Karpf, M, 1981)
"This study compared acid-base and biochemical changes and quality of recovery in male cats with experimentally induced urethral obstruction and anesthetized with either propofol or a combination of ketamine and diazepam for urethral catheterization."5.16Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam. ( Carregaro, AB; da Cunha, JP; da Cunha, MG; Freitas, GC; Gomes, K; Pippi, NL; Togni, M, 2012)
"While some case reports indicate that high doses of propylene glycol (PG) may result in metabolic acidosis, there has been no large-scale study that evaluated the risk of metabolic acidosis in patients receiving PG-containing benzodiazepines for acute alcohol withdrawal."3.88Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model. ( Bodreau, C; Elbarbry, F; Farthing, K; Jahn, A, 2018)
" Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma."3.73Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005)
"Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication."3.67Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984)
"Neuroleptanalgesia was induced in late pregnancy in guinea pigs with diazepam and fentanyl-fluanisone."3.66Acid-base status of pregnant guinea pigs during neuroleptanalgesia with diazepam and fentanyl-fluanisone. ( Carter, AM, 1983)
"A patient with tetanus was treated with high-dose intravenous (IV) diazepam for control of muscular spasms."3.66Induction of lactic acidosis with intravenous diazepam in a patient with tetanus. ( Carey, P; Kapoor, W; Karpf, M, 1981)
"Pyridoxine was given intravenously as an antidote."1.34[Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007)
"Diazepam was given iv in doses that induced light to heavy sedation or general anesthesia."1.26The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide. ( Carlsson, C; Hgerdal, M; Kaasik, AE; Siesjö, BK, 1976)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199014 (63.64)18.7374
1990's0 (0.00)18.2507
2000's6 (27.27)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jahn, A1
Bodreau, C1
Farthing, K1
Elbarbry, F1
Freitas, GC1
da Cunha, MG1
Gomes, K1
da Cunha, JP1
Togni, M1
Pippi, NL1
Carregaro, AB1
Caksen, H1
Odabas, D1
Erol, M1
Anlar, O1
Tuncer, O1
Atas, B1
Ozucelik, DN1
Karcioglu, O1
Topacoglu, H1
Fowler, JR1
Topcu, I1
Yentur, EA1
Kefi, A1
Ekici, NZ1
Sakarya, M1
Eizadi-Mood, N1
Graf, J1
Scheffold, N1
Radunz, W1
Cyran, J1
Pahl, MV1
Vaziri, ND1
Ness, R1
Nathan, R1
Maksy, M1
Jonsson, S1
O'Meara, M1
Young, JB1
Denson, DD1
Myers, JA1
Thompson, GA1
Coyle, DE1
Flecknell, PA1
John, M1
Mitchell, M1
Shurey, C1
Simpkin, S1
Carter, AM1
Kapoor, W1
Carey, P1
Karpf, M1
Lambert, JR1
Byrick, RJ1
Hammeke, MD1
Wilson, KC1
Reardon, C1
Farber, HW1
Sedgwick, CJ1
Carlsson, C1
Hgerdal, M1
Kaasik, AE1
Siesjö, BK1
Bear, ES1
Hoffman, PF1
Siegel, SR1
Randal, RE1
Mehmel, HC1
Clark, RB1
Femi-Pearse, D1
Hutchison, I1
McQuillan, DA1

Reviews

1 review available for diazepam and Acidosis

ArticleYear
Analgesia during labor: effect on the fetus and neonate.
    Clinical anesthesia, 1974, Volume: 10, Issue:2

    Topics: Acidosis; Alphaprodine; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anesthetics; Apgar Score; B

1974

Trials

1 trial available for diazepam and Acidosis

ArticleYear
Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, Volume: 76, Issue:3

    Topics: Acid-Base Equilibrium; Acidosis; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, D

2012

Other Studies

20 other studies available for diazepam and Acidosis

ArticleYear
Assessing Propylene Glycol Toxicity in Alcohol Withdrawal Patients Receiving Intravenous Benzodiazepines: A One-Compartment Pharmacokinetic Model.
    European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:4

    Topics: Acid-Base Equilibrium; Acidosis; Alcoholism; Benzodiazepines; Diazepam; Female; Humans; Injections,

2018
Do not overlook acute isoniazid poisoning in children with status epilepticus.
    Journal of child neurology, 2003, Volume: 18, Issue:2

    Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose;

2003
Toxicity following unintentional DDT ingestion.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Anticonvulsants; Bicarbonates; Buffers; Critical Care; DD

2004
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
    Anaesthesia and intensive care, 2005, Volume: 33, Issue:4

    Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma;

2005
Nalidixic acid overdose and metabolic acidosis.
    CJEM, 2006, Volume: 8, Issue:2

    Topics: Acidosis; Adolescent; Anti-Infective Agents; Anticonvulsants; Cognition Disorders; Diazepam; Drug Ov

2006
[Isoniazid intoxication].
    Deutsche medizinische Wochenschrift (1946), 2007, Jan-05, Volume: 132, Issue:1-2

    Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In

2007
Association of beta hydroxybutyric acidosis with isoniazid intoxication.
    Journal of toxicology. Clinical toxicology, 1984, Volume: 22, Issue:2

    Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; Bicarbonates; Diazepam; Female; Humans; Hydroxybutyrates; Is

1984
Acute cocaine poisoning. Importance of treating seizures and acidosis.
    The American journal of medicine, 1983, Volume: 75, Issue:6

    Topics: Acidosis; Acute Disease; Adult; Bicarbonates; Cocaine; Diazepam; Epilepsy, Tonic-Clonic; Foreign Bod

1983
The influence of diazepam on the serum protein binding of bupivacaine at normal and acidic pH.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:11

    Topics: Acidosis; Bupivacaine; Chromatography, Gas; Diazepam; Drug Interactions; Female; Half-Life; Humans;

1984
Neuroleptanalgesia in the rabbit.
    Laboratory animals, 1983, Volume: 17, Issue:2

    Topics: Acidosis; Animals; Butyrophenones; Diazepam; Drug Combinations; Etorphine; Fentanyl; Hypercapnia; Me

1983
Acid-base status of pregnant guinea pigs during neuroleptanalgesia with diazepam and fentanyl-fluanisone.
    Laboratory animals, 1983, Volume: 17, Issue:2

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Butyrophenones; Diazepam; Drug Combination

1983
Induction of lactic acidosis with intravenous diazepam in a patient with tetanus.
    Archives of internal medicine, 1981, Volume: 141, Issue:7

    Topics: Acidosis; Aged; Diazepam; Female; Humans; Injections, Intravenous; Lactates; Tetanus

1981
Management of acute strychnine poisoning.
    Canadian Medical Association journal, 1981, May-15, Volume: 124, Issue:10

    Topics: Acidosis; Adult; Diazepam; Female; Humans; Strychnine

1981
Propylene glycol toxicity in a patient receiving intravenous diazepam.
    The New England journal of medicine, 2000, Sep-14, Volume: 343, Issue:11

    Topics: Acidosis; Alcohol-Induced Disorders; Diazepam; Humans; Infusions, Intravenous; Male; Middle Aged; Ph

2000
Field anesthesia in stressed animals.
    Modern veterinary practice, 1979, Volume: 60, Issue:7

    Topics: Acepromazine; Acidosis; Anesthesia; Animals; Animals, Zoo; Artiodactyla; Diazepam; Etorphine; Fever;

1979
The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide.
    Anesthesiology, 1976, Volume: 45, Issue:3

    Topics: Acidosis; Animals; Behavior, Animal; Brain; Cerebrovascular Circulation; Diazepam; Dose-Response Rel

1976
Suicidal ingestion of isoniazid: an uncommon cause of metabolic acidosis and seizures.
    Southern medical journal, 1976, Volume: 69, Issue:1

    Topics: Acidosis; Adolescent; Adult; Bicarbonates; Diazepam; Diuresis; Female; Humans; Infusions, Parenteral

1976
[Therapy of acute myocardial infarct].
    Deutsche medizinische Wochenschrift (1946), 1985, May-10, Volume: 110, Issue:19

    Topics: Acidosis; Analgesics; Atropine; Bicarbonates; Bradycardia; Cardiac Complexes, Premature; Critical Ca

1985
Blood gas tensions, acid-base status, and spirometry in tetanus.
    The American review of respiratory disease, 1974, Volume: 110, Issue:4

    Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Carbon Dioxide; Child; Diazepam; Female; Humans;

1974
Anaesthesia and obstetrics.
    The New Zealand medical journal, 1970, Volume: 71, Issue:456

    Topics: Acidosis; Anesthesia, Obstetrical; Benperidol; Diazepam; Female; Fetus; Humans; Infant Mortality; In

1970