diazepam has been researched along with Ache in 242 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Excerpt | Relevance | Reference |
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"Diazepam does not improve patient pain perception immediately after or at 1-week recall after prostate biopsy." | 9.19 | A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate. ( Alsyouf, M; Baldwin, DD; Creech, JD; Culpepper, DJ; Jellison, F; Li, R; Lightfoot, MA; Nicolay, L; Ruckle, HC, 2014) |
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 9.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
"Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously." | 9.10 | A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002) |
"Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt." | 9.08 | Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. ( Nicolodi, M, 1998) |
"To evaluate five different preoperative anxiolytic regimens in cataract surgery performed under regional anesthesia; to quantify the pain associated with combined peri- and retrobulbar injection (PRBI) of local anesthetic drugs; and to describe a technique of painless eye block." | 9.08 | Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery. ( Berry, RA; Boezaart, AP; Laubscher, JJ; Nell, ML, 1998) |
"We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain." | 9.08 | Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997) |
"The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation." | 9.08 | Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998) |
" Thirty-two patients suffering from osteoarthritis were subjected to electroacupuncture, with or without pretreatment with naloxone or diazepam." | 9.07 | Interaction of diazepam and naloxone on acupuncture induced pain relief. ( Eriksson, SV; Lundeberg, S; Lundeberg, T, 1991) |
" The aim of this study was to investigate the sensitivity of pain-related potentials used in experimental pain models to the non-specific effects of the tranquilizer diazepam." | 9.07 | Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. ( Ditterich, W; Kobal, G; Thürauf, N, 1994) |
"To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 9.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
"We studied 41 consecutive patients receiving intravenous (IV) diazepam in the preoperative holding area to evaluate whether low-dose IV lidocaine could ameliorate pain of the diazepam injection." | 9.05 | Lidocaine reduces intravenous diazepam pain. ( Ampel, L; Herr, RD; Natonson, R, 1985) |
"A randomized trial of two different formulations of diazepam--Valium and Diazemuls--in 109 patients undergoing endoscopy demonstrated that diazepam in a lipid emulsion (Diazemuls) greatly reduced the incidence of local pain at the time of injection (P less than 0." | 9.05 | A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls. ( Bullimore, DW, 1982) |
"Eighty-seven patients with an acute myocardial infarction and a pulse rate of greater than or equal to 80/min on admission were randomly allotted to one group given cardioselective beta-blockade, a second group given diazepam, and a third group given placebo." | 9.05 | A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia. ( Johansson, BW, 1980) |
"Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis." | 9.04 | Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam. ( Conner, JT; Graham, CW; Pagano, RR, 1978) |
"This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures." | 7.85 | Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy. ( Hang, MTH; Keck, C; Keshavarzian, A; Sedghi, S; Smith, BE, 2017) |
"The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception." | 7.78 | The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation. ( Casarrubea, M; Crescimanno, G; Santangelo, A; Sorbera, F, 2012) |
"Eight right-handed male volunteers underwent fMRI combined with a thermal pain conditioning paradigm and midazolam (30 mug/kg) or saline administration on different occasions, with order randomized across volunteers." | 7.74 | The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007) |
"We investigated the effects of diazepam (DZ) on a well-known pattern of brain regions activated by cold, tonic pain stimuli." | 7.71 | Diazepam effects on the cerebral responses to tonic pain: a SPET study. ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001) |
"Seizures associated with the intravenous administration of codeine phosphate have not been extensively reported in the literature, and special precautions for using the parenteral route for this drug have been vague and limited." | 7.71 | Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001) |
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
"Pain was rated on visual analogue scales before, during, and after treatment." | 6.67 | A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. ( Eriksson, SV; Lundeberg, T; Thomas, M, 1991) |
"The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 5.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
"Diazepam does not improve patient pain perception immediately after or at 1-week recall after prostate biopsy." | 5.19 | A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate. ( Alsyouf, M; Baldwin, DD; Creech, JD; Culpepper, DJ; Jellison, F; Li, R; Lightfoot, MA; Nicolay, L; Ruckle, HC, 2014) |
"To compare pain and anxiety levels between two prophylactic treatment regimens, a combination of sublingual tramadol Hcl with oral lorazepam and oral diazepam only." | 5.15 | Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study. ( Baruch, Y; Eisenberg, E; Kramskay, R; Tansky, A; Veitsman, E, 2011) |
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls." | 5.11 | The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004) |
"Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously." | 5.10 | A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002) |
"Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt." | 5.08 | Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. ( Nicolodi, M, 1998) |
"Popular depolarising muscle relaxant, suxamethonium (succinylcholine chloride), produces fasciculation in group of muscles and 'after pain'." | 5.08 | Variation of serum potassium and creatinine phosphokinase levels in suxamethonium-induced muscle relaxation. ( Das, BK; Das, BN; Guha, A; Sengupta, S, 1996) |
"Two hundred and seventy-eight patients scheduled for all types of surgery and premedicated with diazepam and metoclopramide were randomly allocated to one of four groups to compare the relative pain of an injection of 0." | 5.08 | Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge). ( Prabhu, NV; Van den Berg, AA, 1995) |
"The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation." | 5.08 | Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998) |
"We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain." | 5.08 | Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997) |
"We investigated the influence of preanesthetic medication on the pain relieving effect of the lidocaine tape during needle insertion for venous cannulation." | 5.08 | [Influence of preanesthetic medication on the effect of a local anesthetic tape]. ( Horikawa, Y; Kagawa, T; Kondo, M; Obara, H; Ohnishi, H, 1997) |
"To evaluate five different preoperative anxiolytic regimens in cataract surgery performed under regional anesthesia; to quantify the pain associated with combined peri- and retrobulbar injection (PRBI) of local anesthetic drugs; and to describe a technique of painless eye block." | 5.08 | Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery. ( Berry, RA; Boezaart, AP; Laubscher, JJ; Nell, ML, 1998) |
" The aim of this study was to investigate the sensitivity of pain-related potentials used in experimental pain models to the non-specific effects of the tranquilizer diazepam." | 5.07 | Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. ( Ditterich, W; Kobal, G; Thürauf, N, 1994) |
" Thirty-two patients suffering from osteoarthritis were subjected to electroacupuncture, with or without pretreatment with naloxone or diazepam." | 5.07 | Interaction of diazepam and naloxone on acupuncture induced pain relief. ( Eriksson, SV; Lundeberg, S; Lundeberg, T, 1991) |
"The analgesic effects of a repetitive stress induced by anticipation of pain (noxious footshock) were studied on both the threshold of a nociceptive flexion reflex and the corresponding pain sensation after a 4-day-treatment of diazepam vs placebo (cross-over and double-blind study) in normal volunteers." | 5.06 | Diazepam reduces stress-induced analgesia in humans. ( Ernst, M; Willer, JC, 1986) |
"This study evaluated the analgesic efficacy of baclofen in relation to specific pain stimuli in 83 women (27 nulliparas and 56 multiparas) undergoing voluntary abortion (clamping of the cervix and dilatation and curettage)." | 5.05 | Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. ( Bacchini, M; Battagliarin, G; Brambilla, C; Corli, O; Di Piazza, D; Grossi, E; Roma, G, 1984) |
"A randomized trial of two different formulations of diazepam--Valium and Diazemuls--in 109 patients undergoing endoscopy demonstrated that diazepam in a lipid emulsion (Diazemuls) greatly reduced the incidence of local pain at the time of injection (P less than 0." | 5.05 | A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls. ( Bullimore, DW, 1982) |
"Eighty-seven patients with an acute myocardial infarction and a pulse rate of greater than or equal to 80/min on admission were randomly allotted to one group given cardioselective beta-blockade, a second group given diazepam, and a third group given placebo." | 5.05 | A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia. ( Johansson, BW, 1980) |
"We studied 41 consecutive patients receiving intravenous (IV) diazepam in the preoperative holding area to evaluate whether low-dose IV lidocaine could ameliorate pain of the diazepam injection." | 5.05 | Lidocaine reduces intravenous diazepam pain. ( Ampel, L; Herr, RD; Natonson, R, 1985) |
"To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0." | 5.05 | Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981) |
"Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis." | 5.04 | Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam. ( Conner, JT; Graham, CW; Pagano, RR, 1978) |
"Diazepam has been reported to reduce pain and discomfort and in many cases to produce a total amnesia." | 5.04 | Diazepam as a sedative in induced abortion. ( Campbell, UD; Madsen, OG; Nielsen, JB, 1975) |
"Based upon the currently available evidence in patients with IA, benzodiazepines (diazepam and triazolam) do not appear to be beneficial in improving pain over 24 hours or 1 week." | 4.88 | The efficacy and safety of muscle relaxants in inflammatory arthritis: a Cochrane systematic review. ( Buchbinder, R; Richards, BL; van der Heijde, DM; Whittle, SL, 2012) |
"This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures." | 3.85 | Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy. ( Hang, MTH; Keck, C; Keshavarzian, A; Sedghi, S; Smith, BE, 2017) |
"It is established that mebicar, amitriptyline, and diazepam administered intraperitoneally at therapeutic doses increase the pain thresholds in mice as manifested in "hot plate" analgesia test." | 3.81 | [Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam]. ( Khaziakhmetova, VN; Luchai, KV; Ziganshina, LE, 2015) |
"The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception." | 3.78 | The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation. ( Casarrubea, M; Crescimanno, G; Santangelo, A; Sorbera, F, 2012) |
" Etizolam was effective in reducing the pain for only about 30 minutes." | 3.77 | A case of thalamic pain successfully treated with Kampo medicine. ( Chino, A; Kasahara, Y; Namiki, T; Ogawa, K; Okamoto, H; Terasawa, K; Ueda, K, 2011) |
"Diazepam-reduced experimental anxiety was paralleled by antinociceptive effects." | 3.76 | Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2010) |
"Eight right-handed male volunteers underwent fMRI combined with a thermal pain conditioning paradigm and midazolam (30 mug/kg) or saline administration on different occasions, with order randomized across volunteers." | 3.74 | The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007) |
"We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 3.74 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
" The role of factors with anxiogenic properties produced during inflammation, which may modify diazepam and buspirone effects, is discussed." | 3.73 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005) |
"Seizures associated with the intravenous administration of codeine phosphate have not been extensively reported in the literature, and special precautions for using the parenteral route for this drug have been vague and limited." | 3.71 | Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001) |
"We investigated the effects of diazepam (DZ) on a well-known pattern of brain regions activated by cold, tonic pain stimuli." | 3.71 | Diazepam effects on the cerebral responses to tonic pain: a SPET study. ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001) |
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
" For unanesthetized tubes the mean pain rating depended on the dose of diazepam and fentanyl given to the patient (p less than ." | 3.65 | Laparoscopic tubal clip sterilization under local anesthesia. ( Edelman, DA; Fishburne, JI; Hulka, JF; Mercer, JP; Omran, KF, 1974) |
"Diazepam and midazolam were equivalent as judged by sedation, recovery time, patient tolerance, and ease of examination." | 2.69 | Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. ( Gevers, AM; Hendrickx, A; Macken, E; Rutgeerts, P, 1998) |
"Pain was rated on visual analogue scales before, during, and after treatment." | 2.67 | A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. ( Eriksson, SV; Lundeberg, T; Thomas, M, 1991) |
"Midazolam is a recently introduced benzodiazepine with a half life of 1-4 hours." | 2.66 | A comparison of midazolam and diazepam for sedation during locoregional anesthesia. ( Donadoni, R; Herregods, L; Mortier, E; Rolly, G, 1987) |
"No pain was experienced by patients receiving thiopentone." | 2.65 | Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia. ( Aromaa, U; Korttila, K; Tammisto, T, 1979) |
"The diazepam was dissolved in cremophor and this reduced the pain of intravenous injection of the diazepam." | 2.64 | Intravenous sedation and regional analgesia. ( Gjessing, J; Tomlin, PJ, 1977) |
" The combination of diclofenac sodium and metamizole sodium is acceptable, although, at a lower dosage of metamizole, the duration of analgesia is shortened." | 2.46 | Evidence-based intravenous pain treatment with analgesic infusion regimens. ( Cihal, P; Kamyar, MR; Lemmens-Gruber, R; Nemec, K; Timin, E, 2010) |
"Pain is a common and debilitating symptom of inflammatory bowel disease (IBD)." | 1.72 | Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. ( Gold, MS; Loeza-Alcocer, E, 2022) |
"Diazepam treatment alone did not produce significant antinociception." | 1.56 | Effects of oxycodone and diazepam alone and in combination on operant nociception. ( Kangas, BD; Leonard, MZ, 2020) |
"Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
"Intratracheal suctioning evoked significant changes in some physiological and behavioral parameters." | 1.38 | Assessment of pain in sedated and mechanically ventilated patients: an observational study. ( Hamers, JP; Hantikainen, V; Jakob, SM; Jeitziner, MM; Rohrer, O; Schwendimann, R, 2012) |
"CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: (1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), (2) a decrease in number of central squares visited in the open field (OF), and (3) a reduction in active social interactions in the social interaction test (SI)." | 1.38 | Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. ( Beaudet, N; Beaudry, H; Bergeron, J; Bérubé, P; Drolet, G; Gendron, L; Parent, AJ; Sarret, P, 2012) |
"Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production." | 1.37 | Antinociceptive properties of bergenin. ( Couto, RD; David, JM; David, JP; de Lima, FO; de Oliveira, CM; Nonato, FR; Soares, MB; Villarreal, CF, 2011) |
"This is a case report of a CPP treated by a pain physician." | 1.35 | Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009) |
"Diazepam or yohimbine were administered 15 min before uric acid and the ability of the rat to use the injured hind limb was recorded." | 1.33 | Influence of pharmacologically-induced experimental anxiety on nociception and antinociception in rats. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2006) |
"Midazolam 2." | 1.28 | [The effects of pentazocine, diazepam and midazolam in patients to reduce the uncomfortable feeling during epidural block procedure]. ( Kasaba, T, 1992) |
"Diazepam (3 mg/kg) was followed by eating during the 1st hour after administration in non-food-deprived rats and a reduction in the behaviour triggered by a mild tail-pinch 90 min after drug administration." | 1.28 | Effect of diazepam on behaviour and associated changes in ascorbate concentration in rat brain areas: striatum, n. accumbens and hippocampus. ( Boutelle, MG; Fillenz, M; Svensson, L, 1990) |
"The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice." | 1.26 | [Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979) |
"Pain was positively associated with 1) age of 15 years or less, 2) with gestation of less than 7 weeks or more than 12 and with dilatation on a curvilnear basis, and 3) with patient fear." | 1.26 | Pain of first-trimester abortion: its quantification and relations with other variables. ( Chirchirillo, L; McCarthy, MJ; Smith, GM; Stubblefield, PG, 1979) |
"The adverse effects in a series of 50 lumbar myelographies with Amipaque were compared with those in a corresponding series, examined with Dimer-X." | 1.26 | Adverse effects of lumbar myelography with amipaque and dimer-X. ( Irstam, L; Selldén, U, 1976) |
"Early detection and treatment of drug abuse should minimize some of the difficulties involved in management of treatment-resistive patients with chronic pain." | 1.26 | Drug abuse and dependency in patients with chronic pain. ( Finlayson, RE; Maruta, T; Swanson, DW, 1979) |
"This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally." | 1.25 | Myofascial pain dysfunction syndrome involving tumor metastasis. Case report. ( Butler, JH, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 152 (62.81) | 18.7374 |
1990's | 36 (14.88) | 18.2507 |
2000's | 26 (10.74) | 29.6817 |
2010's | 24 (9.92) | 24.3611 |
2020's | 4 (1.65) | 2.80 |
Authors | Studies |
---|---|
Liu, H | 1 |
Altenbach, RJ | 1 |
Carr, TL | 1 |
Chandran, P | 1 |
Hsieh, GC | 1 |
Lewis, LG | 1 |
Manelli, AM | 1 |
Milicic, I | 1 |
Marsh, KC | 1 |
Miller, TR | 1 |
Strakhova, MI | 1 |
Vortherms, TA | 1 |
Wakefield, BD | 1 |
Wetter, JM | 1 |
Witte, DG | 1 |
Honore, P | 1 |
Esbenshade, TA | 1 |
Brioni, JD | 1 |
Cowart, MD | 1 |
de Oliveira, CM | 1 |
Nonato, FR | 1 |
de Lima, FO | 1 |
Couto, RD | 1 |
David, JP | 1 |
David, JM | 1 |
Soares, MB | 2 |
Villarreal, CF | 3 |
Guerrini, G | 1 |
Ciciani, G | 1 |
Bruni, F | 1 |
Selleri, S | 1 |
Martini, C | 1 |
Daniele, S | 1 |
Ghelardini, C | 1 |
Di Cesare Mannelli, L | 1 |
Costanzo, A | 1 |
Gama, KB | 1 |
Quintans, JS | 1 |
Antoniolli, AR | 1 |
Quintans-Júnior, LJ | 1 |
Santana, WA | 1 |
Branco, A | 1 |
Tripathi, P | 1 |
Tripathi, AC | 1 |
Chawla, V | 1 |
Saraf, SK | 1 |
Lima, Mda S | 1 |
Evangelista, AF | 1 |
Santos, GG | 1 |
Ribeiro, IM | 1 |
Tomassini, TC | 1 |
Pereira Soares, MB | 1 |
Loeza-Alcocer, E | 1 |
Gold, MS | 1 |
Ng, DYT | 1 |
Lo, A | 1 |
So, EWS | 1 |
Wong, GCY | 1 |
Li, RHW | 1 |
Wong, YY | 1 |
Ng, EHY | 1 |
Leonard, MZ | 1 |
Kangas, BD | 1 |
Diester, CM | 1 |
Santos, EJ | 1 |
Moerke, MJ | 2 |
Negus, SS | 2 |
Carter, C | 1 |
Viveash, S | 1 |
Hang, MTH | 1 |
Smith, BE | 1 |
Keck, C | 1 |
Keshavarzian, A | 1 |
Sedghi, S | 1 |
Li, G | 1 |
Golani, LK | 1 |
Cook, J | 1 |
Okamoto, M | 1 |
Takahagi, S | 1 |
Kamegashira, A | 1 |
Yanase, Y | 1 |
Hide, M | 1 |
Li, R | 1 |
Ruckle, HC | 1 |
Creech, JD | 1 |
Culpepper, DJ | 1 |
Lightfoot, MA | 1 |
Alsyouf, M | 1 |
Nicolay, L | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641] | 61 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
Smart Pain Assesment Tool Based on Internet of Things[NCT03061240] | 58 participants (Actual) | Interventional | 2017-11-20 | Completed | |||
19-Gauge Fine Needle Aspirate (FNA) Versus 19-Gauge Fine Needle Biopsy (FNB) Needles for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB): A Randomized Prospective Trial[NCT03408171] | 40 participants (Actual) | Interventional | 2017-10-02 | Completed | |||
19 Versus 22-Gauge Fine Needle Biopsy (FNB) Needles for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB): A Prospective Pilot Study[NCT02967991] | 20 participants (Actual) | Interventional | 2016-08-31 | Completed | |||
Comparison of Pain Scores Between Endoscopic Ultrasound (EUS)-Guided Liver Biopsy and Percutaneous Liver Biopsy[NCT02947516] | 0 participants (Actual) | Interventional | 2017-01-31 | Withdrawn (stopped due to Funding n/a) | |||
Contribution of Hypnosis in Guided Hepatic Biopsy[NCT05413174] | 70 participants (Actual) | Interventional | 2022-09-29 | Completed | |||
Intravenous Injection of Diazepam at the Beginning of Active Phase of Labor[NCT02232035] | Phase 2 | 400 participants (Anticipated) | Interventional | 2014-09-30 | Not yet recruiting | ||
An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366] | Phase 4 | 121 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
Auricular Acupuncture as Adjunct for Pain Management During First Trimester Uterine Aspiration.[NCT03391986] | 153 participants (Actual) | Interventional | 2017-09-09 | Completed | |||
Pain Measurement in Healthy Volunteers[NCT00001597] | 40 participants | Observational | 1997-03-31 | Completed | |||
Postoperative Pain Control in Extracapsular Hip Fracture Patients: Fascia Iliaca Compartment Block Versus Fracture Block[NCT04335461] | Early Phase 1 | 0 participants (Actual) | Interventional | 2021-08-05 | Withdrawn (stopped due to Study was withdrawn. Study expired in IRB system and no patients enrolled as per institutional CTMS and IRB systems. Primary and Study Completion Dates reflect date IRB approval expired.) | ||
"Comparison of Ultrasound-guided Hematoma Block and Blind Hematoma Block for Analgesia in Distal Radius Fractures"[NCT02346929] | 115 participants (Anticipated) | Interventional | 2014-08-31 | Recruiting | |||
Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain[NCT04744883] | Early Phase 1 | 240 participants (Anticipated) | Interventional | 2020-08-10 | Recruiting | ||
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function[NCT02469077] | 117 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
Acupuncture for Vasectomy Pre-procedural Anxiety and Pain Control in the Primary Care Setting: A Randomized Comparative Effectiveness Trial[NCT03938415] | 85 participants (Anticipated) | Interventional | 2019-06-01 | Recruiting | |||
Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure During Congenital Pulmonary Stenosis Balloon Dilatation[NCT05582213] | 40 participants (Actual) | Interventional | 2022-10-01 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT03408171)
Timeframe: Number Analyzed
Intervention | mm (Median) |
---|---|
19-gauge FNA Needle | 32.3 |
19-gauge FNB Needle | 30.2 |
Number of portal triads (PT) in the specimen. (NCT03408171)
Timeframe: 3-5 days
Intervention | Portal Triads (Mean) |
---|---|
19-gauge FNA Needle | 18.1 |
19-gauge FNB Needle | 42.6 |
Number of portal triads (PT) in the specimen. (NCT03408171)
Timeframe: 3-5 days
Intervention | Complete number of portal triads (Median) |
---|---|
19-gauge FNA Needle | 16.5 |
19-gauge FNB Needle | 38 |
Post-processing Aggregate specimen length (ASL) measured in centimeter (NCT03408171)
Timeframe: 3-5 days
Intervention | centimeter (Mean) |
---|---|
19-gauge FNA Needle | 11.4 |
19-gauge FNB Needle | 15.32 |
Post-processing Length of the longest piece (LLP) measured in centimeter (NCT03408171)
Timeframe: 3-5 days
Intervention | centimeter (Mean) |
---|---|
19-gauge FNA Needle | 1.05 |
19-gauge FNB Needle | 1.78 |
Pre-processing Aggregate specimen length (ASL) measured in centimeter (NCT03408171)
Timeframe: 3-5 days
Intervention | centimeter (Mean) |
---|---|
19-gauge FNA Needle | 10.89 |
19-gauge FNB Needle | 15.78 |
Pre-processing Length of the longest piece (LLP) measured in centimeter (NCT03408171)
Timeframe: up to 5 days
Intervention | centimeter (Mean) |
---|---|
19-gauge FNA Needle | 1.47 |
19-gauge FNB Needle | 2.09 |
Number of cases for which a histologic diagnosis could be made based upon the amount of tissue obtained with the needle. (NCT03408171)
Timeframe: 3-5 days
Intervention | Participants (Count of Participants) |
---|---|
19-gauge FNA Needle | 20 |
19-gauge FNB Needle | 20 |
No. of fragments > 9 mm, mean (SD) Pre-processing Post-processing (NCT03408171)
Timeframe: 3-5 days
Intervention | Number of Fragments (Mean) | |
---|---|---|
Pre-processing | Post-processing | |
19-gauge FNA Needle | 3.5 | 1.1 |
19-gauge FNB Needle | 7.7 | 4.8 |
"Length of all the tissue (centimeters) by adding the sum of all pieces Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | cm for portal tracts of specimens (Mean) |
---|---|
19 Gauge FNA | 76.5 |
22 Gauge FNB | 66.9 |
"length of the longest tissue biopsy piece (centimeters) as measured by pathology Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | mean cm for portal tracts of specimens (Mean) |
---|---|
19 Gauge FNA | 13.2 |
22 Gauge FNB | 10.8 |
"Number of portal tracts (PT) in the specimen (total) under histologic examination Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | mean portal tracts (Mean) |
---|---|
19 Gauge FNA | 7.4 |
22 Gauge FNB | 6.1 |
"Defined by total portal structures > 5 or length of the longest piece > 15 mm) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | specimens (Number) |
---|---|
19 Gauge FNA | 17 |
22 Gauge FNB | 14 |
"Patient requiring visit to healthcare center (emergency room, hospital, call to service) within time 7 days Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 Days
Intervention | Participants (Count of Participants) |
---|---|
Total Population | 1 |
"Pain using Likert score 0-10 (10 worst) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 1 days
Intervention | Participants (Count of Participants) |
---|---|
Total Population | 0 |
"Pain using Likert score 0-10 (10 worst) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | Participants (Count of Participants) |
---|---|
Total Population | 1 |
"Patient with blood visible from patient's mouth, rectum with a 2 gram drop in hemoglobin Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days
Intervention | Participants (Count of Participants) |
---|---|
Total Population | 0 |
"Presence of visible clots in specimen (yes/no) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: Day of Procedure
Intervention | specimens (Number) |
---|---|
19 Gauge FNA | 4 |
22 Gauge FNB | 1 |
"Presence of a visible core specimen (yes/no) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: Day of Procedure
Intervention | specimens (Number) |
---|---|
19 Gauge FNA | 20 |
22 Gauge FNB | 19 |
Measure effectiveness of placebo as an adjunct to ibuprofen and paracervical block for pain control during uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive placebo adhesives and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). (NCT03391986)
Timeframe: prior to the procedure (baseline), at the completion of the procedure (approximately 10 minutes later)
Intervention | score on a scale (Mean) |
---|---|
Placebo Adhesives | 70.0 |
Routine Care | 71.0 |
Using a satisfaction survey (investigator-developed, 6 questions, each question is graded on a scale of 1-5, 1 being very poor and 5 being very good) to measure effectiveness of auricular acupuncture for improving satisfaction. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 5-10 minutes)
Intervention | percentage of participants (Number) |
---|---|
Pyonex Needles | 94 |
Routine Care | 76 |
Measure effectiveness of auricular acupuncture as an adjunct to ibuprofen and paracervical block for pain control during first trimester uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive auricular acupuncture and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). The VAS has no sub-scales. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 10 minutes later)
Intervention | score on a scale (Mean) |
---|---|
Pyonex Needles | 39.5 |
Routine Care | 71.0 |
Mean change in 5-day electronic diary ratings of low back pain intensity from pre intervention baseline to post intervention. 9 point pain scale assessing pain intensity with 0 represents no pain and 8 represents worst possible pain. Positive values indicate reduced pain post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 2.75 | 0.72 |
Normal Exercise (Control) | 2.82 | 0.18 |
Mean change in McGill Pain Questionnaire-2 total chronic back pain ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-10 where 0 represents no pain and 10 represents most intense pain. Positive values indicate decreased back pain post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 2.66 | 1.60 |
Normal Exercise (Control) | 3.01 | 1.36 |
Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Drug Effect subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 1-5 where 1 represents no effect and 5 represents very strong effect. Positive values indicate decreased overall drug effects post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 2.72 | 0.10 |
Normal Exercise (Control) | 2.52 | -0.12 |
Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Drug Liking subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-100 where 0 represents dislike a lot and 100 represents like a lot. Positive values indicate decreased drug liking post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 52.03 | 4.13 |
Normal Exercise (Control) | 52.89 | 1.04 |
Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Take Again subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-100 where 0 represents definitely would not take again and 100 represents definitely would take again. Positive values indicate decreased desire to take the drug again post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 54.49 | 4.40 |
Normal Exercise (Control) | 55.04 | 1.70 |
Mean change in morphine condition VAS Opioid Effects - Unpleasantness subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 represents no unpleasantness and 300 represents most unpleasantness possible. Positive values indicate decreased unpleasantness post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 33.58 | -3.21 |
Normal Exercise (Control) | 16.52 | 1.86 |
Mean change in morphine condition VAS Opioid Effects-Euphoria subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 means no euphoria and 300 means most euphoria possible. Positive values indicate decreased euphoria post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 100.60 | 3.19 |
Normal Exercise (Control) | 108.24 | 0.75 |
Mean change in morphine condition VAS Opioid Effects-Sedation subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 means no sedation and 300 means most sedation possible. Positive values indicate decreased sedation post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 66.58 | 12.89 |
Normal Exercise (Control) | 30.63 | -9.95 |
Mean change in placebo condition ratings of acute thermal pain intensity using the McGill Pain Questionnaire-Short Form on 3 testing days at baseline (per intervention) and post intervention. The score ranges from 0-33 where 0 represents no pain and 33 represents most intense pain. Positive change values indicate decreased pain responsiveness post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 10.23 | 0.45 |
Normal Exercise (Control) | 7.83 | -2.14 |
Mean change in Positive and Negative Affect Scale-Negative Affect subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. . Scale ratings range from 10 to 50 where 10 represents lowest negative affect possible and 50 represents highest negative affect possible. Positive values indicate decreased negative affect post intervention. (NCT02469077)
Timeframe: At pre intervention baseline and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 16.38 | 0.45 |
Normal Exercise (Control) | 15.43 | -2.14 |
"At a laboratory testing day pre and post intervention each participant received morphine sulphate (0.3mg/kg in 20ml saline vehicle initially, followed by 3 incremental doses of 0.02 mg/kg each with testing for thermal evoked pain response. Weight adjusted dosing was used by multiplying the weight of each patient in kg by 0.3mg (dose 1 only) or by .02mg (doses 2-4), with all doses infused in 20mL saline vehicle.~Mean of the change in morphine dosage required to achieve 25 % reduction in thermal evoked pain responses on testing day at baseline (pre-intervention) and post intervention. Positive values for the change in the mean between pre and post intervention indicated decreased morphine requirements post intervention." (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)
Intervention | mg (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 4.17 | -1.62 |
Normal Exercise (Control) | 6.34 | 0.92 |
"Between-participant (aerobic exercise vs. control group) comparison of mean changes from pre- to post-intervention in opioid blockade effects for McGill Pain Questionnaire-2 Total ratings of back pain based on 3 laboratory testing days at baseline (pre intervention) and post intervention. The score ranges from 0-10 where 0 represents no pain and 10 represents most intense pain. Positive values indicate increased endogenous opioid analgesia post intervention.~This measure will test the effects of the exercise (versus control) intervention on clinical outcomes as indexed by changes in opioid blockade effects (the difference in laboratory evoked pain response evoked between placebo and naloxone drug conditions).~This is a mixed within-between subject design. Per the study protocol, the intent of outcome measures 4 and 6 was to capture opioid blockade effects (within-participant placebo-naloxone condition difference scores) at both the pre- and post-intervention lab assessments, an" (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | 0.11 | -0.12 |
Normal Exercise (Control) | 0.18 | -0.24 |
"Between-participant (aerobic exercise vs. control group) comparison of mean changes from pre- to post-intervention in opioid blockade effects for ratings of acute thermal pain intensity on the McGill Pain Questionnaire-Short Form based on 3 laboratory testing days at baseline (pre-intervention) and post intervention. The score ranges from 0-33 where 0 represents no pain and 33 represents more intense pain. Positive values indicate increased endogenous opioid analgesia post intervention.~This measure will test for endogenous opioid mechanisms of the exercise (versus control) intervention as indexed by changes in opioid blockade effects (the difference in laboratory evoked pain response evoked between placebo and naloxone drug conditions).~This is a mixed within-between subject design. Per the study protocol, the intent of outcome measures 4 and 6 was to capture opioid blockade effects (within-participant placebo-naloxone condition difference scores) at both the pre- and post-in" (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline (pre intervention) | Change after 6 week intervention period | |
6 Week Aerobic Exercise Intervention | -0.33 | 1.97 |
Normal Exercise (Control) | 0.92 | -0.61 |
11 reviews available for diazepam and Ache
Article | Year |
---|---|
A primer of ethical issues involving opioid therapy for chronic nonmalignant pain in a multidisciplinary setting.
Topics: Analgesics, Opioid; Chickenpox; Cholecystectomy; Chronic Disease; Diazepam; Facial Pain; Female; Her | 2009 |
Evidence-based intravenous pain treatment with analgesic infusion regimens.
Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Diazepam; Diclofenac; Drug | 2010 |
The efficacy and safety of muscle relaxants in inflammatory arthritis: a Cochrane systematic review.
Topics: Analgesics; Arthritis, Rheumatoid; Diazepam; Drug Therapy, Combination; Humans; Muscle Relaxants, Ce | 2012 |
Levator ani syndrome - a case study and literature review.
Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Anus Diseases; Baths; Diazepam; Family P | 2007 |
Autoanalgesia: opiate and non-opiate mechanisms.
Topics: Animals; Central Nervous System; Conditioning, Classical; Diazepam; Electroshock; Emotions; Endorphi | 1980 |
Systemic analgesia during labor.
Topics: Acid-Base Equilibrium; Analgesics; Animals; Child Behavior; Diazepam; Female; Fentanyl; Fetal Heart; | 1982 |
Comparing drugs for short-term sedation.
Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; | 1994 |
Signal detection theory measurement of pain: a review and critique.
Topics: Acupuncture Therapy; Age Factors; Diazepam; Discrimination, Psychological; Electric Stimulation; Fem | 1977 |
Hyperalgesia induced by emotional stress in the rat: an experimental animal model of human anxiogenic hyperalgesia.
Topics: Analgesia; Animals; Anxiety; Diazepam; Disease Models, Animal; Emotions; Humans; Hypophysectomy; Pai | 1986 |
Advances in neurology.
Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra | 1968 |
Pain control and patient management in dentistry--a review of current intravenous technics.
Topics: Anesthesia, Intravenous; Dentistry; Diazepam; Humans; Injections, Intravenous; Medical History Takin | 1970 |
63 trials available for diazepam and Ache
Article | Year |
---|---|
A randomized controlled study of acupuncture for pain relief during first trimester surgical termination of pregnancy performed under local analgesia.
Topics: Acupuncture Therapy; Analgesia; Diazepam; Female; Humans; Pain; Pregnancy; Pregnancy Trimester, Firs | 2022 |
A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Endoscopic Ultrasound-Guided Fine Needle A | 2014 |
Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study.
Topics: Adult; Analgesia; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Biopsy, Needle; Diazepam; Female | 2011 |
A prospective randomized trial comparing patient-controlled sedation using propofol and alfentanil and physician-administered sedation using diazepam and pethidine during transvaginal ultrasound-guided oocyte retrieval.
Topics: Adult; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Conscious Sedation; Diazepam; | 2002 |
A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam.
Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Diazepam; Double-Blind Method; Female; Human | 2002 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
Prevalence and characteristics of pain induced by percutaneous liver biopsy.
Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid | 2003 |
The effect of ketamine and fentanyl in reducing the pain of diazepam injection.
Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Diazepam; Double-Blind Method; Fentanyl; Hu | 2004 |
Dexamethasone dose attenuates pain on injection following diazepam hydrochloride.
Topics: Adult; Dexamethasone; Diazepam; Double-Blind Method; Humans; Injections; Male; Metoclopramide; Middl | 2005 |
Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in patients.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind M | 1980 |
Venous complications after i.v. administration of Diazemuls (diazepam) and Dormicum (midazolam).
Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Female; Humans; Injections, Intravenous | 1981 |
Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion.
Topics: Abortion, Induced; Adolescent; Adult; Baclofen; Clinical Trials as Topic; Diazepam; Dilatation and C | 1984 |
Venous complications of two diazepam preparations related to size of vein.
Topics: Arm; Diazepam; Endoscopy; Hand; Humans; Pain; Thrombophlebitis; Veins | 1983 |
Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl.
Topics: Adolescent; Adult; Aged; Anesthesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Droper | 1981 |
A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls.
Topics: Diazepam; Drug Evaluation; Emulsions; Endoscopy; Humans; Injections, Intravenous; Pain; Solutions | 1982 |
Analgesic and euphoric effects of high dose diazepam in schizophrenia.
Topics: Adult; Analgesia; Diazepam; Endorphins; Euphoria; Female; Humans; Male; Middle Aged; Naloxone; Pain; | 1982 |
A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia.
Topics: Age Factors; Aged; Blood Gas Analysis; Blood Pressure; Body Temperature; Diazepam; Female; Humans; M | 1980 |
Local reactions to i.v. diazepam in three different formulations.
Topics: Adult; Castor Oil; Diazepam; Emulsions; Glycerol; Humans; Infusions, Parenteral; Pain; Propylene Gly | 1980 |
Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge).
Topics: Adolescent; Adult; Bloodletting; Catheterization, Peripheral; Diazepam; Equipment Design; Female; Hu | 1995 |
Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam.
Topics: Acoustic Stimulation; Adult; Carbon Dioxide; Chemoreceptor Cells; Cross-Over Studies; Dental Pulp; D | 1994 |
Classification and premedication of uncooperative children.
Topics: Acepromazine; Attention; Child; Child Behavior; Child, Preschool; Cooperative Behavior; Dental Anxie | 1993 |
Variation of serum potassium and creatinine phosphokinase levels in suxamethonium-induced muscle relaxation.
Topics: Adult; Anesthetics, Intravenous; Creatine Kinase; Diazepam; Drug Therapy, Combination; Female; Human | 1996 |
Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain.
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Diazepam; Double-Blind Method; Female; Fentanyl | 1997 |
[Influence of preanesthetic medication on the effect of a local anesthetic tape].
Topics: Adjuvants, Anesthesia; Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents | 1997 |
Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Intravenous; Antidotes; | 1998 |
Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery.
Topics: Aged; Alprazolam; Anesthesia, Local; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Bromazepam; B | 1998 |
Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid.
Topics: Adult; Cross-Over Studies; Diazepam; Double-Blind Method; Excitatory Amino Acids; gamma-Aminobutyric | 1998 |
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cros | 1998 |
Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Metho | 1978 |
A comparison of hypnosis, acupuncture, morphine, valium, aspirin, and placebo in the management of experimentally induced pain.
Topics: Acupuncture Therapy; Adolescent; Adult; Analgesia; Aspirin; Diazepam; Humans; Hypnosis; Male; Morphi | 1977 |
Intravenous sedation and regional analgesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Clinical Trials as Topic; Diazepam; Female; Humans; | 1977 |
Intramuscular diazepam in labour. A double-blind trial in multiparae.
Topics: Clinical Trials as Topic; Diazepam; Female; Humans; Injections, Intramuscular; Labor, Obstetric; Mep | 1977 |
Pain associated with peripheral angiography: is lidocaine effective?
Topics: Aged; Angiography; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; Lidocain | 1978 |
Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia.
Topics: Adult; Anesthesia, General; Diazepam; Etomidate; Fentanyl; Humans; Imidazoles; Middle Aged; Movement | 1979 |
Effect of premedication on etomidate anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Atropine; Diazepam; Etomidate; Fentanyl; Humans; I | 1979 |
Diazepam in emulsion form for intravenous usage.
Topics: Adjuvants, Anesthesia; Clinical Trials as Topic; Diazepam; Drug Evaluation; Emulsions; Female; Human | 1976 |
Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response.
Topics: Adolescent; Adult; Analgesics; Anxiety; Diazepam; Dronabinol; Heart Rate; Humans; Injections, Intrav | 1977 |
Reactions to intravenous injections of diazepam.
Topics: Diazepam; Humans; Injections, Intravenous; Pain; Solvents; Thrombophlebitis; Time Factors | 1976 |
[Diazepam in obstetrics. A double-blind study on duration of labor, pain, Apgar score and complications].
Topics: Apgar Score; Clinical Trials as Topic; Diazepam; Drug Evaluation; Female; Humans; Infant, Newborn; L | 1975 |
Diazepam as a sedative in induced abortion.
Topics: Abortion, Induced; Adolescent; Adult; Clinical Trials as Topic; Diazepam; Female; Humans; Middle Age | 1975 |
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation.
Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli | 1992 |
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation.
Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli | 1992 |
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation.
Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli | 1992 |
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation.
Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli | 1992 |
Interaction of diazepam and naloxone on acupuncture induced pain relief.
Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa | 1991 |
Interaction of diazepam and naloxone on acupuncture induced pain relief.
Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa | 1991 |
Interaction of diazepam and naloxone on acupuncture induced pain relief.
Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa | 1991 |
Interaction of diazepam and naloxone on acupuncture induced pain relief.
Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa | 1991 |
A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study.
Topics: Acupuncture Analgesia; Adult; Cervical Vertebrae; Chronic Disease; Diazepam; Humans; Middle Aged; Os | 1991 |
An investigation of cognitive-behavior therapy combined with oral valium for children undergoing painful medical procedures.
Topics: Arousal; Bone Marrow Examination; Child; Child, Preschool; Cognitive Behavioral Therapy; Combined Mo | 1991 |
Short report: sedation for upper gastrointestinal endoscopy--diazepam versus midazolam.
Topics: Adolescent; Adult; Aged; Diazepam; Endoscopy, Gastrointestinal; Female; Humans; Male; Midazolam; Mid | 1990 |
A stress inoculation program for parents whose children are undergoing painful medical procedures.
Topics: Biopsy, Needle; Bone Marrow; Child; Child, Preschool; Cognitive Behavioral Therapy; Combined Modalit | 1990 |
Relaxation response in femoral angiography.
Topics: Angiography; Anxiety; Diazepam; Femoral Artery; Fentanyl; Humans; Music; Pain; Random Allocation; Re | 1990 |
Influence of CGP 361A, propranolol and diazepam on autonomous reactions to different stressors.
Topics: Adrenergic beta-Antagonists; Adult; Anxiety; Autonomic Nervous System; Blood Pressure; Diazepam; Dou | 1989 |
Diazepam mixed micelle--comparison with diazepam in propylene glycol and midazolam.
Topics: Benzodiazepines; Blood Pressure; Diazepam; Female; Heart Rate; Humans; Micelles; Midazolam; Pain; Ph | 1985 |
Neuroendocrine effects of diazepam in normal subjects following brief painful stress.
Topics: Adult; beta-Endorphin; Diazepam; Humans; Hydrocortisone; Male; Pain; Stress, Physiological | 1988 |
Failure of two benzodiazepines to prevent suxamethonium-induced muscle pain.
Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Diazepam; Double-Blind Method; Female; Humans; Male; | 1985 |
Double-blind comparison of nalbuphine and meperidine in combination with diazepam for intravenous conscious sedation in oral surgery outpatients.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anxiety; Diazepam; Double-Blind Method; Female; Humans | 1988 |
[Does diazepam prevent fasciculation and myalgias caused by suxamethonium? A double-blind study].
Topics: Clinical Trials as Topic; Diazepam; Double-Blind Method; Fasciculation; Female; Gallamine Triethiodi | 1987 |
A comparison of midazolam and diazepam for sedation during locoregional anesthesia.
Topics: Adult; Anesthesia, Local; Diazepam; Double-Blind Method; Female; Hemodynamics; Humans; Male; Midazol | 1987 |
Reliability and validity of verbal descriptor scales of painfulness.
Topics: Adolescent; Adult; Diazepam; Electric Stimulation; Female; Fentanyl; Humans; Male; Pain; Pain Measur | 1987 |
Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery.
Topics: Diazepam; Double-Blind Method; Drug Evaluation; Endorphins; Fentanyl; Humans; Intraoperative Period; | 1986 |
Lidocaine reduces intravenous diazepam pain.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; In | 1985 |
Diazepam reduces stress-induced analgesia in humans.
Topics: Adult; Analgesia; Diazepam; Differential Threshold; Dose-Response Relationship, Drug; Double-Blind M | 1986 |
Use of methylprednisolone acetate in vasectomy.
Topics: Clinical Trials as Topic; Codeine; Diazepam; Disability Evaluation; Follow-Up Studies; Humans; Male; | 1974 |
Alterations in response to somatic pain associated with anaesthesia. XIX: Studies with the drugs used in neuroleptanaesthesia.
Topics: Affect; Benperidol; Clinical Trials as Topic; Diazepam; Drug Synergism; Female; Fentanyl; Heroin; Hu | 1970 |
[Doxepin--a new anxiolytic antidepressant].
Topics: Antidepressive Agents; Anxiety; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Depression; | 1970 |
[An experimental study on the premedication effect of promethazine and diazepam].
Topics: Adult; Dental Pulp Test; Diazepam; Female; Humans; Male; Pain; Placebos; Premedication; Promethazine | 1971 |
[Experiences with faustan for the prevention of muscle pain from succinyl choline administration].
Topics: Atropine; Diazepam; Female; Humans; Male; Meperidine; Muscles; Pain; Succinylcholine | 1970 |
[The reaction of the skin vessels in pain irritation and its pharmacologic susceptibility].
Topics: Adult; Aminopyrine; Diazepam; Emotions; Female; Hemodynamics; Humans; Male; Middle Aged; Pain; Respi | 1966 |
168 other studies available for diazepam and Ache
Article | Year |
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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Antinociceptive properties of bergenin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Dose-Response Relationshi | 2011 |
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.
Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan | 2011 |
Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
Topics: Agave; Analgesics; Animals; Glyburide; KATP Channels; Male; Mice; Molecular Structure; Naltrexone; P | 2013 |
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug; | 2014 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.
Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammator | 2022 |
Effects of oxycodone and diazepam alone and in combination on operant nociception.
Topics: Analgesics; Animals; Conditioning, Operant; Diazepam; Drug Therapy, Combination; Male; Models, Anima | 2020 |
Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls.
Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; False Ne | 2021 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy.
Topics: Administration, Topical; Analgesics; Chronic Disease; Diazepam; Dose-Response Relationship, Drug; Dr | 2017 |
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Electric Stimulation; Ketoro | 2019 |
Successful treatment of refractory dermal pain with etizolam and clonazepam in a patient with acquired idiopathic generalized anhidrosis.
Topics: Adult; Biopsy; Clonazepam; Diazepam; Drug Resistance; Drug Therapy, Combination; Gabapentin; Glucoco | 2019 |
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.
Topics: Analgesia; Animals; Arginine; Benzodiazepines; Diazepam; GABA Modulators; Gene Expression; Histidine | 2015 |
[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam].
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Biureas; Diazepam; Female; Ma | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; | 2009 |
Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Area Under Curve; Behavior, Animal; Diazepam; Disea | 2010 |
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach.
Topics: Acetic Acid; Action Potentials; Analgesics; Animals; Behavior, Animal; Biological Assay; Diazepam; E | 2010 |
A case of thalamic pain successfully treated with Kampo medicine.
Topics: Aged; Analgesics; Diazepam; Female; Humans; Infarction; Medicine, Kampo; Movement Disorders; Nausea; | 2011 |
Safety of subcutaneous microinjections (mesotherapy) in musicians.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diazepam; Female; Humans; In | 2011 |
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dark Adaptation; Diaze | 2012 |
Assessment of pain in sedated and mechanically ventilated patients: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Analysis of Variance; Behavior; Cons | 2012 |
The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Male; Motor Activity; | 2012 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxy | 2012 |
ROLE OF RELAXANTS IN TREATMENT OF TRAUMATIC MUSCULOSKELETAL DISORDERS: A DOUBLE-BLIND STUDY OF THREE AGENTS.
Topics: Anxiety; Anxiety Disorders; Biomedical Research; Carisoprodol; Chlormezanone; Diazepam; Double-Blind | 1964 |
EVALUATION OF DIAZEPAM (VALIUM) IN THE SYMPTOMATIC TREATMENT OF RHEUMATIC DISORDERS. A CONTROLLED COMPARATIVE STUDY.
Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Carisoprodol; Chlormezanone; Diazepa | 1965 |
PAINFUL MUSCULAR CONDITIONS TREATED WITH DIAZEPAM.
Topics: Biomedical Research; Diazepam; Humans; Pain | 1965 |
THE LEVATOR SYNDROME AND ITS TREATMENT.
Topics: Anus Diseases; Diazepam; Drug Therapy; Humans; Pain; Sacrococcygeal Region; Spasm | 1965 |
[ON THE DIAGNOSIS AND THERAPY OF MYOGENIC PAIN IN DEGENERATIVE CHANGES OF THE SPINE IN GERIATRICS].
Topics: Diazepam; Geriatrics; Humans; Muscle Cramp; Pain; Spinal Diseases | 1964 |
Pharmacological characterisation of acid-induced muscle allodynia in rats.
Topics: Acids; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Carbazoles; Chr | 2004 |
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D | 2005 |
A new assay of thermal-based avoidance test in freely moving mice.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Biological A | 2005 |
Modifications in avoidance reactions of mice, on a second exposure to the hot plate, resist to various amnesia-inducing treatments.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Dementia; Diaz | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; | 2006 |
Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia.
Topics: Adaptation, Physiological; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convu | 2006 |
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Ago | 2006 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Influence of pharmacologically-induced experimental anxiety on nociception and antinociception in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Diazepam; Do | 2006 |
Adequacy of pain relief in closed manipulative reduction of fracture and dislocation.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Analgesia; Child; Cross-Sectional Studies; Diazepam; | 2006 |
The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI.
Topics: Anti-Anxiety Agents; Behavior; Brain; Brain Mapping; Cohort Studies; Color; Diazepam; Humans; Light; | 2007 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz | 2008 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper | 2008 |
[On the significance of affects for the behavior of the peripheral blood vessels and their modification by pharmaceuticals].
Topics: Adult; Aminopyrine; Diazepam; Female; Humans; Male; Middle Aged; Pain; Skin; Triflupromazine; Vascul | 1966 |
When drugs can help in multiple sclerosis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Baclofen; Dantrolene; Diazepam; Humans; Immuno | 1980 |
Analgesia induced by painful stimulation and/or anticipation of pain; different mechanisms are operating.
Topics: Analgesia; Animals; Chlorpromazine; Dexamethasone; Diazepam; Electric Stimulation; Humans; Naloxone; | 1984 |
[Effect of benzodiazepines on neuropathologic syndromes of spinal origin].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Myoclonus; P | 1984 |
Pain-induced vocalization in the rat and its modification by pharmacological agents.
Topics: Animals; Diazepam; Electric Stimulation; Emotions; Heart Rate; Male; Morphine; Pain; Rats; Rats, Inb | 1984 |
Long-term use of diazepam.
Topics: Adult; Aged; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Muscle Cramp; Nordazepam; Pain; | 1981 |
Painful intravenous injections of diazepam.
Topics: Diazepam; Humans; Pain; Propylene Glycol; Propylene Glycols | 1983 |
Diazepam-induced suppression of jaw opening reflex in rats.
Topics: Analgesics; Animals; Dental Pulp; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; | 1980 |
Aspirin in the prevention of painful intravenous injection of disoprofol (ICI35,868) and diazepam (Valium).
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics; Aspirin; Diazepam; Female; Fentanyl; Humans | 1982 |
Diazepam-induced release of opioid activity in the rat brain.
Topics: Analgesics; Animals; Bacitracin; Brain; Diazepam; Enkephalins; Male; Pain; Rats; Rats, Inbred Strain | 1980 |
[Tasks and problems of general medical care in certain groups of disorders. Patients with mixed (motor and sensory) paralyses--from a neurological viewpoint].
Topics: Baclofen; Demyelinating Diseases; Diazepam; Electrogalvanism, Intraoral; Exercise Therapy; Hemiplegi | 1982 |
Diazepam in an oil emulsion.
Topics: Adult; Aged; Diazepam; Double-Blind Method; Emulsions; Humans; Injections, Intravenous; Middle Aged; | 1982 |
Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs.
Topics: Adolescent; Adult; Dental Pulp; Diazepam; Double-Blind Method; Drug Evaluation; Electric Stimulation | 1982 |
Reversibility of diazepam overdose by physostigmine.
Topics: Acoustic Stimulation; Animals; Cats; Diazepam; Female; Male; Pain; Physostigmine | 1981 |
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; | 1980 |
Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component.
Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Diazepam; gamma-Aminobuty | 1980 |
Prevention of pain and phlebitis due to diazepam injection.
Topics: Diazepam; Humans; Injections, Intravenous; Pain; Phlebitis | 1980 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehy | 1995 |
Altered responses to medications exposed to excessive temperatures during shipping.
Topics: Chronic Disease; Diazepam; Drug Stability; Drug Storage; Female; Hot Temperature; Humans; Meperidine | 1995 |
Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cholecystokinin; Chronic Disease; Diazepam; Endorphi | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Stress-induced hypoalgesia and defensive freezing are attenuated by application of diazepam to the amygdala.
Topics: Amygdala; Analysis of Variance; Animals; Diazepam; Fear; Female; Motor Activity; Pain; Rats; Stress, | 1993 |
High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Conflict, Psychological; Diazepam; Ind | 1997 |
Comparison of pain, motility, and preoperative sedation in cataract phacoemulsification patients receiving peribulbar or sub-Tenon's anesthesia.
Topics: Anesthesia, Local; Anesthetics, Local; Diazepam; Eye Movements; Follow-Up Studies; Humans; Hypnotics | 1998 |
Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient.
Topics: Amygdala; Animals; Anti-Anxiety Agents; beta-Galactosidase; Diazepam; Enkephalins; Gene Expression R | 1999 |
[Pediatricians' opinion on sedation in children].
Topics: Adult; Age Factors; Aged; Anesthesia; Anti-Anxiety Agents; Attitude of Health Personnel; Child; Chlo | 1999 |
Antinociceptive effects of the tubercles of Anredera leptostachys.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Caribbean Region; Diazepam; Dose-Response Relati | 1999 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
Seizures with intravenous codeine phosphate.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Anticonvulsants; Child; Codeine; Diazepam; Humans; Injectio | 2001 |
Diazepam effects on the cerebral responses to tonic pain: a SPET study.
Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Brain; Cold Temperature; Diazepam; Humans; Male; P | 2001 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
Letter: Injecting the painful shoulder.
Topics: Cyclizine; Diazepam; Drug Therapy, Combination; Humans; Injections, Intra-Articular; Injections, Int | 1976 |
Drug-induced encephalopathy in patients on maintenance haemodialysis.
Topics: Aged; Anti-Anxiety Agents; Arthritis; Coronary Disease; Dementia; Diazepam; Flurazepam; Fractures, B | 1976 |
[Investigations on pain reduction during peripheral angiography (author's transl)].
Topics: Angiography; Diazepam; Extremities; Female; Femoral Artery; Humans; Injections, Intravenous; Male; M | 1979 |
[Antistress effects of diazepam and activation of the positive reinforcing system upon changes on corticosteroid excretion and lipid level after peripheral electric pain stimulation].
Topics: 11-Hydroxycorticosteroids; Animals; Diazepam; Electric Stimulation; Lipoproteins; Lipoproteins, LDL; | 1979 |
Conscious sedation with intravenous drugs: a study of amnesia.
Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Anxiety; Diazepam; Drug Combinations; F | 1978 |
The effects of diazepam, morphine and lidocaine on nociception in rhesus monkeys: a signal detection analysis.
Topics: Animals; Diazepam; Discrimination, Psychological; Electric Stimulation; Escape Reaction; Haplorhini; | 1978 |
Drug abuse and dependency in patients with chronic pain.
Topics: Age Factors; Chronic Disease; Codeine; Dextropropoxyphene; Diazepam; Female; Humans; Intelligence; M | 1979 |
[Use of phentanyl with droperidol or seduxen in nitrous oxide anesthesia in patients with blood vessel diseases of the lower extremities accompanied by pain syndrome].
Topics: Adult; Anesthesia, Inhalation; Diazepam; Droperidol; Fentanyl; Humans; Middle Aged; Nitrous Oxide; P | 1979 |
[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities].
Topics: Adult; Aged; Anesthesia, Endotracheal; Diazepam; Droperidol; Drug Therapy, Combination; Fentanyl; Hu | 1979 |
Pain of first-trimester abortion: its quantification and relations with other variables.
Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai | 1979 |
Pain of first-trimester abortion: its quantification and relations with other variables.
Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai | 1979 |
Pain of first-trimester abortion: its quantification and relations with other variables.
Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai | 1979 |
Pain of first-trimester abortion: its quantification and relations with other variables.
Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai | 1979 |
Analgesic action and pharmacokinetics of morphine and diazepam in man: an evaluation by sensory decision theory.
Topics: Analgesics; Diazepam; Humans; Kinetics; Male; Morphine; Pain; Placebos; Sodium Chloride | 1979 |
A clinical study of local reactions following intravenous diazepam.
Topics: Diazepam; Female; Humans; Injections, Intravenous; Male; Pain; Thrombophlebitis | 1979 |
[Differential diagnostic criteria in cervico-brachial psychalgia].
Topics: Brachial Plexus Neuritis; Conflict, Psychological; Diagnosis, Differential; Diazepam; Galvanic Skin | 1979 |
[Preliminary clinical observations on the use of the narcotic, Etomidate, in anesthesiology. Evaluation of the MPC dose and equivalent dose].
Topics: Adolescent; Adult; Anesthesia; Diazepam; Dose-Response Relationship, Drug; Etomidate; Humans; Imidaz | 1979 |
Psychopharmacology for psychiatric and psychiatric-organic diseases.
Topics: Antidepressive Agents, Tricyclic; Anxiety; Depression; Diazepam; Dose-Response Relationship, Drug; D | 1978 |
Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: manipulation of affect by diazepam.
Topics: Adolescent; Adult; Affect; Diazepam; Electric Stimulation; Female; Humans; Male; Pain; Sensation; Ti | 1978 |
Effect of pain on human psychomotor performance.
Topics: Adult; Diazepam; Flicker Fusion; Humans; Male; Motor Activity; Motor Skills; Pain; Time Factors; Vit | 1978 |
Uptake of 3H-leucine into the brain and other organs during the conditioned reaction to painful stimulation; effect of diazepam.
Topics: Animals; Brain; Conditioning, Classical; Diazepam; Humans; Leucine; Male; Nerve Tissue Proteins; Org | 1976 |
Chronic MPD, group therapy and psychodynamics.
Topics: Attitude; Diazepam; Ethanol; Facial Muscles; Humans; Interpersonal Relations; Meprobamate; MMPI; Mus | 1975 |
Myofascial pain dysfunction syndrome involving tumor metastasis. Case report.
Topics: Breast Neoplasms; Diagnosis, Differential; Diazepam; Facial Muscles; Female; Humans; Mandibular Neop | 1975 |
Chronic myofascial pain-dysfunction syndrome with chest pain.
Topics: Adult; Diazepam; Facial Muscles; Female; Humans; Malocclusion; Masticatory Muscles; Muscular Disease | 1975 |
Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery.
Topics: Adolescent; Adult; Anxiety; Cannabis; Diazepam; Dronabinol; Emotions; Hippocampus; Humans; Injection | 1976 |
Physiological responses under dental sedation and anaesthesia.
Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate; | 1976 |
[Effect of diazepam on coronary circulation and myocardial metabolism in subjects with normal coronary arteries and patients with coronary arteriosclerosis].
Topics: Adult; Arteriosclerosis; Coronary Circulation; Coronary Disease; Diazepam; Female; Hemodynamics; Hum | 1975 |
Letter: some pitfalls in the psychophysical assessment of drug effects: another look at the effects of diazepam on pain threshold.
Topics: Diazepam; Drug Evaluation; Humans; Pain; Psychology | 1975 |
Adverse effects of lumbar myelography with amipaque and dimer-X.
Topics: Adult; Aged; Brain; Diazepam; Drug Evaluation; Electroencephalography; Female; Fever; Headache; Huma | 1976 |
[The effects of pentazocine, diazepam and midazolam in patients to reduce the uncomfortable feeling during epidural block procedure].
Topics: Adult; Anesthesia, Epidural; Anxiety; Diazepam; Female; Humans; Male; Midazolam; Pain; Pentazocine; | 1992 |
Effects of diazepam and chlorpromazine on socially induced anxiety in pigeons.
Topics: Animals; Anxiety; Chlorpromazine; Columbidae; Conditioning, Operant; Diazepam; Dose-Response Relatio | 1991 |
Premedication and short term complications in iohexol discography.
Topics: Adult; Back Pain; Diazepam; Female; Glycopyrrolate; Headache; Humans; Injections, Spinal; Interverte | 1991 |
[The legal importance of immediate pain in injection errors].
Topics: Diazepam; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Ma | 1991 |
[Premedication and analgesic dose procedures in dental medicine].
Topics: Anesthesia, Dental; Anesthesia, Local; Buprenorphine; Clorazepate Dipotassium; Diazepam; Flunitrazep | 1991 |
Morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Mo | 1990 |
Effect of diazepam on behaviour and associated changes in ascorbate concentration in rat brain areas: striatum, n. accumbens and hippocampus.
Topics: Animals; Ascorbic Acid; Behavior, Animal; Brain Chemistry; Corpus Striatum; Diazepam; Electrodes, Im | 1990 |
Diazepam attenuates morphine antinociception test-dependently in mice.
Topics: Analgesics; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Mal | 1990 |
[Control of pain and anxiety in pedodontics].
Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Diazepam; Humans; Hydroxyzine; Ketamine; Nitro | 1989 |
Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline.
Topics: Amitriptyline; Animals; Behavior, Animal; Denervation; Diazepam; Hindlimb; Male; Pain; Peripheral Ne | 1989 |
Noradrenergic mechanisms in mediation of stress-induced hyperalgesia in rats.
Topics: Analgesia; Animals; Clonidine; Diazepam; Norepinephrine; Pain; Rats; Receptors, Adrenergic, alpha; S | 1988 |
Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Cholecystokinin; Diaz | 1985 |
[Analysis of the influence of anxiolytics on the pain reactions of rats compared to the effect of morphine].
Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation | 1987 |
The possible role of benzodiazepine receptors in morphine analgesia.
Topics: Animals; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Male; Mice; Morphine; Pain; Rec | 1986 |
Neurobehavioral, neuroendocrine and neurochemical effects of zinc supplementation in rats.
Topics: Adrenocorticotropic Hormone; Animals; Baclofen; Behavior, Animal; beta-Endorphin; Brain; Diazepam; E | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricula | 1986 |
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component.
Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil; | 1987 |
Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice.
Topics: Analgesia; Animals; Appetitive Behavior; Diazepam; Flumazenil; Handling, Psychological; Hot Temperat | 1988 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin | 1988 |
[Prevention of myalgia after intravenous administration of succinylcholine iodide].
Topics: Anesthesia, General; Diazepam; Fasciculation; Humans; Injections, Intravenous; Muscles; Pain; Succin | 1988 |
Conditional analgesia, defensive freezing, and benzodiazepines.
Topics: Animals; Benzodiazepines; Conditioning, Classical; Cytidine Diphosphate; Defense Mechanisms; Diazepa | 1988 |
One stressful event blocks multiple actions of diazepam for up to at least a month.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Diazepam; Dopamine; Male; Pain; Pentylenet | 1988 |
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male; | 1987 |
Somatovegetative changes in stress-induced analgesia in man: an electrophysiological and pharmacological study.
Topics: Adult; Analgesia; Diazepam; Double-Blind Method; Electrophysiology; Female; H-Reflex; Heart Rate; Hu | 1986 |
Influence of diazepam on the effects of suxamethonium.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Diazepam; Fasciculation; Female; Humans; Male; Middle Ag | 1986 |
[Does diazepam prevent against suxamethonium-induced fasciculation and myalgia?].
Topics: Diazepam; Fasciculation; Humans; Muscular Diseases; Pain; Succinylcholine | 1987 |
Intrathecal diazepam suppresses nociceptive reflexes and potentiates electroacupuncture effects in pentobarbital-anesthetized rats.
Topics: Acupuncture Therapy; Anesthesia, Intravenous; Animals; Diazepam; Drug Synergism; Humans; Injections, | 1987 |
[Effects of lidocaine, meperidine or fentanyl on pain and clinical thrombophlebitis induced by intravenous diazepam].
Topics: Adult; Diazepam; Female; Fentanyl; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Lido | 1987 |
Assessment and management of chronic pain.
Topics: Analgesics; Anticonvulsants; Antidepressive Agents; Chronic Disease; Diazepam; Hospital Units; Human | 1986 |
Sedation and pain management during pacemaker implantation, electrophysiologic testing, and related procedures.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Local; Diazepam; Electrophysiology; Female; Humans; | 1985 |
Differential diagnosis of weakness--a common geriatric symptom.
Topics: Aged; Alcoholism; Arthritis; Cardiovascular Diseases; Depression; Diabetes Complications; Diagnosis, | 1986 |
Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Pain; Rats; React | 1986 |
Iatrogenic and functional leg pain.
Topics: Aged; Analgesics; Aspirin; Diagnosis, Differential; Diazepam; Fear; Fibromyalgia; Humans; Iatrogenic | 1973 |
Editorial: Anguish unremembered?
Topics: Amnesia; Anesthesia; Anesthesia, Dental; Autonomic Nervous System; Consciousness; Diazepam; Humans; | 1974 |
[Analgesia in myocardial infarct].
Topics: Analgesics; Diazepam; Heart; Hemodynamics; Heroin; Humans; Hydromorphone; Meperidine; Methadone; Mor | 1974 |
Anesthesia for diagnostic and operative laparoscopy.
Topics: Abdomen; Adolescent; Adult; Analgesia; Anesthesia; Anesthesia, General; Anesthesia, Local; Diazepam; | 1971 |
[Syndromes of permanent contracture (stiff-man syndrome of Moersch and Woltman; Isaacs' syndrome of continual activity of the muscle fibers, other permanent contractures). Attempted classification and pathogenic interpretation. Discussion of the role of t
Topics: Carbamazepine; Contracture; Diazepam; Electromyography; Fibromyalgia; Hydantoins; Interneurons; Moto | 1971 |
Laparoscopic tubal clip sterilization under local anesthesia.
Topics: Adult; Anesthesia, Local; Diazepam; Drug Evaluation; Fallopian Tubes; Female; Fentanyl; Humans; Lapa | 1974 |
The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. II. Toxicity and analgetic effect of MZ-144 compared to narcotic and non-narcotic analgesics.
Topics: Aminopyrine; Amobarbital; Analgesics; Animals; Aspirin; Blood; Cats; Codeine; Diazepam; Dogs; Drug A | 1971 |
[Neuroleptics, thymoleptics and tranquilizers in neurological therapy].
Topics: Basal Ganglia Diseases; Chlordiazepoxide; Chlorpromazine; Diazepam; Epilepsy; Extrapyramidal Tracts; | 1969 |
Head and neck pain: T-M joint syndrome.
Topics: Adult; Age Factors; Aged; Diagnosis, Differential; Diazepam; Female; Head; Humans; Lidocaine; Male; | 1974 |
[Treatment of acute emotional disturbances].
Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char | 1974 |
Diazepam compared to thiopentone as induction agent for caesarean sections.
Topics: Amnesia; Anesthesia, Intravenous; Anesthesia, Obstetrical; Apgar Score; Atropine; Cesarean Section; | 1974 |
Use of sedation-analgesia in general dentistry.
Topics: Analgesia; Anesthesia, Dental; Diazepam; Humans; Meperidine; Nitrous Oxide; Pain; Pentobarbital; Sco | 1973 |
Sleep studies and therepeutic trial with L-dopa in a case of Stiffman syndrome.
Topics: Benzodiazepinones; Chlorobenzenes; Diazepam; Dihydroxyphenylalanine; Electrocardiography; Electromyo | 1973 |
[Analgesia and stress relief in oral surgery with local anesthesia].
Topics: Anesthesia, Local; Diazepam; Humans; Injections, Intravenous; Pain; Pentazocine; Preanesthetic Medic | 1973 |
Control of the anxiety-pain complex in dentistry. Intravenous psychosedation with techniques using diazepam.
Topics: Anesthesia, Intravenous; Anxiety; Atropine; Blood Pressure; Dental Care; Diazepam; Evaluation Studie | 1974 |
Facial pain as a presentation in Von Munchausen's syndrome: a case report.
Topics: Adult; Diazepam; Electroencephalography; Face; Humans; Male; Munchausen Syndrome; Neurologic Examina | 1974 |
[Influences of some tranquillizers on analgesic effect of aminopyrine (author's transl)].
Topics: Aminopyrine; Animals; Diazepam; Drug Combinations; Hydroxyzine; Mice; Pain | 1974 |
[Serum creatine phosphokinase and intramuscular injections].
Topics: Adult; Creatine Kinase; Diazepam; Female; Humans; Hydroxybutyrate Dehydrogenase; Injections, Intramu | 1973 |
Epileptic pain. An uncommon manifestation with localizing value.
Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma | 1973 |
[Valium in the daily surgical and orthopedic practice].
Topics: Aged; Diazepam; Female; Humans; Male; Middle Aged; Minor Surgical Procedures; Orthopedics; Pain | 1973 |
Patient's views on general anaesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam; | 1973 |
Spinal fracture following radiculography using meglumine iothalamate (Conray).
Topics: Adipates; Adult; Contrast Media; Diazepam; Female; Fractures, Bone; Humans; Hypesthesia; Iothalamic | 1973 |
[A further case of tetanus-like contracture distinct from the stiff man syndrome. Pharmacological and neuropathological study of a case of predominantly spinal encephalomyelitis].
Topics: Aged; Carbamazepine; Contracture; Diazepam; Dihydroxyphenylalanine; Electromyography; Encephalomyeli | 1973 |
[The effect tranquilizers and antidepressants on the summation of impulses of different modalities].
Topics: Animals; Auditory Perception; Central Nervous System; Chlordiazepoxide; Conditioning, Classical; Dep | 1973 |
Effect of diazepam on experimentally induced pain thresholds.
Topics: Anesthesia, Local; Diazepam; Epinephrine; Hot Temperature; Humans; Leg; Pain; Pressure; Skin Tests; | 1974 |
Letter: Cremophor EL as a diluent for diazepam.
Topics: Diazepam; Humans; Injections, Intravenous; Pain; Pharmaceutic Aids; Solubility | 1974 |
[Painless delivery with paracervical block and changes in the concentration of the local anesthetic in the blood].
Topics: Adolescent; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood P | 1971 |
Drugs in the management of myocardial infarction.
Topics: Anti-Arrhythmia Agents; Anxiety; Arrhythmias, Cardiac; Diazepam; Humans; Morphine; Myocardial Infarc | 1971 |
[Effect of sedatives on pain threshold].
Topics: Adult; Diazepam; Female; Humans; Hypnotics and Sedatives; Meperidine; Pain; Pentazocine; Pentobarbit | 1971 |
[The stiff man syndrome].
Topics: Diazepam; Electromyography; Female; Fibromyalgia; Humans; Middle Aged; Muscular Diseases; Pain; Tach | 1971 |
Pain control in dentistry.
Topics: Anesthesia, Dental; Diazepam; Pain; Pentazocine; Prilocaine | 1971 |
[Possibilities and limits of modification of symptoms in the spondylogenous syndrome with psychotropic substances].
Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Diazepam; Humans; Middle Aged; Pain; Rheuma | 1969 |
[Use of tranquilizers in relief of postoperative pain].
Topics: Diazepam; Humans; Hydroxyzine; Meperidine; Pain; Postoperative Care; Tranquilizing Agents | 1970 |
[Neuropsychotropic drugs in the treatment of so-called pain syndromes].
Topics: Aminobutyrates; Benperidol; Chronic Disease; Diazepam; Humans; Hydantoins; Neuralgia; Pain; Procaina | 1970 |
[Drug combinations in the treatment of pain in hemophiliacs].
Topics: Analgesics; Child; Dextromoramide; Diazepam; Hemophilia A; Humans; Pain; Phenoperidine | 1966 |
[Labor pain under the influence of Valium-Rocue and objective evaluation based on the algotocogram].
Topics: Anesthesia, Obstetrical; Diazepam; Female; Humans; Labor, Obstetric; Pain; Pregnancy; Uterus | 1966 |