diazepam and Ache studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"Diazepam does not improve patient pain perception immediately after or at 1-week recall after prostate biopsy."	9.19	A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate. ( Alsyouf, M; Baldwin, DD; Creech, JD; Culpepper, DJ; Jellison, F; Li, R; Lightfoot, MA; Nicolay, L; Ruckle, HC, 2014)
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls."	9.11	The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004)
"Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously."	9.10	A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002)
"Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt."	9.08	Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. ( Nicolodi, M, 1998)
"To evaluate five different preoperative anxiolytic regimens in cataract surgery performed under regional anesthesia; to quantify the pain associated with combined peri- and retrobulbar injection (PRBI) of local anesthetic drugs; and to describe a technique of painless eye block."	9.08	Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery. ( Berry, RA; Boezaart, AP; Laubscher, JJ; Nell, ML, 1998)
"We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain."	9.08	Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997)
"The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation."	9.08	Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998)
" Thirty-two patients suffering from osteoarthritis were subjected to electroacupuncture, with or without pretreatment with naloxone or diazepam."	9.07	Interaction of diazepam and naloxone on acupuncture induced pain relief. ( Eriksson, SV; Lundeberg, S; Lundeberg, T, 1991)
" The aim of this study was to investigate the sensitivity of pain-related potentials used in experimental pain models to the non-specific effects of the tranquilizer diazepam."	9.07	Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. ( Ditterich, W; Kobal, G; Thürauf, N, 1994)
"To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0."	9.05	Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981)
"We studied 41 consecutive patients receiving intravenous (IV) diazepam in the preoperative holding area to evaluate whether low-dose IV lidocaine could ameliorate pain of the diazepam injection."	9.05	Lidocaine reduces intravenous diazepam pain. ( Ampel, L; Herr, RD; Natonson, R, 1985)
"A randomized trial of two different formulations of diazepam--Valium and Diazemuls--in 109 patients undergoing endoscopy demonstrated that diazepam in a lipid emulsion (Diazemuls) greatly reduced the incidence of local pain at the time of injection (P less than 0."	9.05	A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls. ( Bullimore, DW, 1982)
"Eighty-seven patients with an acute myocardial infarction and a pulse rate of greater than or equal to 80/min on admission were randomly allotted to one group given cardioselective beta-blockade, a second group given diazepam, and a third group given placebo."	9.05	A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia. ( Johansson, BW, 1980)
"Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis."	9.04	Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam. ( Conner, JT; Graham, CW; Pagano, RR, 1978)
"This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures."	7.85	Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy. ( Hang, MTH; Keck, C; Keshavarzian, A; Sedghi, S; Smith, BE, 2017)
"The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception."	7.78	The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation. ( Casarrubea, M; Crescimanno, G; Santangelo, A; Sorbera, F, 2012)
"Eight right-handed male volunteers underwent fMRI combined with a thermal pain conditioning paradigm and midazolam (30 mug/kg) or saline administration on different occasions, with order randomized across volunteers."	7.74	The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007)
"We investigated the effects of diazepam (DZ) on a well-known pattern of brain regions activated by cold, tonic pain stimuli."	7.71	Diazepam effects on the cerebral responses to tonic pain: a SPET study. ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001)
"Seizures associated with the intravenous administration of codeine phosphate have not been extensively reported in the literature, and special precautions for using the parenteral route for this drug have been vague and limited."	7.71	Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001)
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."	7.69	Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
"Pain was rated on visual analogue scales before, during, and after treatment."	6.67	A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. ( Eriksson, SV; Lundeberg, T; Thomas, M, 1991)
"The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice."	5.26	[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979)
"Diazepam does not improve patient pain perception immediately after or at 1-week recall after prostate biopsy."	5.19	A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate. ( Alsyouf, M; Baldwin, DD; Creech, JD; Culpepper, DJ; Jellison, F; Li, R; Lightfoot, MA; Nicolay, L; Ruckle, HC, 2014)
"To compare pain and anxiety levels between two prophylactic treatment regimens, a combination of sublingual tramadol Hcl with oral lorazepam and oral diazepam only."	5.15	Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study. ( Baruch, Y; Eisenberg, E; Kramskay, R; Tansky, A; Veitsman, E, 2011)
" Fentanyl also may reduce the pain of diazepam injection by blocking the opiate receptors in vessels walls."	5.11	The effect of ketamine and fentanyl in reducing the pain of diazepam injection. ( Azemati, M; Azemati, S; Khosravi, A; Khosravi, MB, 2004)
"Metoclopramide, rather than lidocaine pretreatment, may be a reasonable analgesic alternative to decrease pain from a diazepam injection, especially when there is a medical condition in which lidocaine should be used very cautiously."	5.10	A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. ( Hassannasab, B; Khan, ZH; Majedi, H; Rabiee, M, 2002)
"Having a differential sensitivity to morphine can distinguish migraine suffers from healthy people who are headache-exempt."	5.08	Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. ( Nicolodi, M, 1998)
"Popular depolarising muscle relaxant, suxamethonium (succinylcholine chloride), produces fasciculation in group of muscles and 'after pain'."	5.08	Variation of serum potassium and creatinine phosphokinase levels in suxamethonium-induced muscle relaxation. ( Das, BK; Das, BN; Guha, A; Sengupta, S, 1996)
"Two hundred and seventy-eight patients scheduled for all types of surgery and premedicated with diazepam and metoclopramide were randomly allocated to one of four groups to compare the relative pain of an injection of 0."	5.08	Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge). ( Prabhu, NV; Van den Berg, AA, 1995)
"The purpose of the present study is to compare the injection pain of propofol with that of benzodiazepines when used for intravenous sedation."	5.08	Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. ( Fukuda, K; Ichinohe, T; Kaneko, Y; Kasahara, M; Mamiya, H; Noma, T, 1998)
"We compared the analgesic effect of intravenous dose titration of fentanyl with diazepam (active placebo) or saline (inert placebo) in 53 patients with different types of neuropathic pain."	5.08	Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. ( Dellemijn, PL; Vanneste, JA, 1997)
"We investigated the influence of preanesthetic medication on the pain relieving effect of the lidocaine tape during needle insertion for venous cannulation."	5.08	[Influence of preanesthetic medication on the effect of a local anesthetic tape]. ( Horikawa, Y; Kagawa, T; Kondo, M; Obara, H; Ohnishi, H, 1997)
"To evaluate five different preoperative anxiolytic regimens in cataract surgery performed under regional anesthesia; to quantify the pain associated with combined peri- and retrobulbar injection (PRBI) of local anesthetic drugs; and to describe a technique of painless eye block."	5.08	Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery. ( Berry, RA; Boezaart, AP; Laubscher, JJ; Nell, ML, 1998)
" The aim of this study was to investigate the sensitivity of pain-related potentials used in experimental pain models to the non-specific effects of the tranquilizer diazepam."	5.07	Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. ( Ditterich, W; Kobal, G; Thürauf, N, 1994)
" Thirty-two patients suffering from osteoarthritis were subjected to electroacupuncture, with or without pretreatment with naloxone or diazepam."	5.07	Interaction of diazepam and naloxone on acupuncture induced pain relief. ( Eriksson, SV; Lundeberg, S; Lundeberg, T, 1991)
"The analgesic effects of a repetitive stress induced by anticipation of pain (noxious footshock) were studied on both the threshold of a nociceptive flexion reflex and the corresponding pain sensation after a 4-day-treatment of diazepam vs placebo (cross-over and double-blind study) in normal volunteers."	5.06	Diazepam reduces stress-induced analgesia in humans. ( Ernst, M; Willer, JC, 1986)
"This study evaluated the analgesic efficacy of baclofen in relation to specific pain stimuli in 83 women (27 nulliparas and 56 multiparas) undergoing voluntary abortion (clamping of the cervix and dilatation and curettage)."	5.05	Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. ( Bacchini, M; Battagliarin, G; Brambilla, C; Corli, O; Di Piazza, D; Grossi, E; Roma, G, 1984)
"A randomized trial of two different formulations of diazepam--Valium and Diazemuls--in 109 patients undergoing endoscopy demonstrated that diazepam in a lipid emulsion (Diazemuls) greatly reduced the incidence of local pain at the time of injection (P less than 0."	5.05	A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls. ( Bullimore, DW, 1982)
"Eighty-seven patients with an acute myocardial infarction and a pulse rate of greater than or equal to 80/min on admission were randomly allotted to one group given cardioselective beta-blockade, a second group given diazepam, and a third group given placebo."	5.05	A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia. ( Johansson, BW, 1980)
"We studied 41 consecutive patients receiving intravenous (IV) diazepam in the preoperative holding area to evaluate whether low-dose IV lidocaine could ameliorate pain of the diazepam injection."	5.05	Lidocaine reduces intravenous diazepam pain. ( Ampel, L; Herr, RD; Natonson, R, 1985)
"To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0."	5.05	Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. ( Adam, AA; Giezen, J; Helmers, JH, 1981)
"Eighty-seven per cent of surgical patients receiving undiluted diazepam experienced pain on injection while 6-16%, depending on the dose, manifested evidence of clinical thrombophlebitis."	5.04	Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam. ( Conner, JT; Graham, CW; Pagano, RR, 1978)
"Diazepam has been reported to reduce pain and discomfort and in many cases to produce a total amnesia."	5.04	Diazepam as a sedative in induced abortion. ( Campbell, UD; Madsen, OG; Nielsen, JB, 1975)
"Based upon the currently available evidence in patients with IA, benzodiazepines (diazepam and triazolam) do not appear to be beneficial in improving pain over 24 hours or 1 week."	4.88	The efficacy and safety of muscle relaxants in inflammatory arthritis: a Cochrane systematic review. ( Buchbinder, R; Richards, BL; van der Heijde, DM; Whittle, SL, 2012)
"This is a single institution nonexperimental study intended to analyze the therapeutic efficacy of topical diazepam in treating symptoms of chronic anal fissures."	3.85	Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy. ( Hang, MTH; Keck, C; Keshavarzian, A; Sedghi, S; Smith, BE, 2017)
"It is established that mebicar, amitriptyline, and diazepam administered intraperitoneally at therapeutic doses increase the pain thresholds in mice as manifested in "hot plate" analgesia test."	3.81	[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam]. ( Khaziakhmetova, VN; Luchai, KV; Ziganshina, LE, 2015)
"The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception."	3.78	The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation. ( Casarrubea, M; Crescimanno, G; Santangelo, A; Sorbera, F, 2012)
" Etizolam was effective in reducing the pain for only about 30 minutes."	3.77	A case of thalamic pain successfully treated with Kampo medicine. ( Chino, A; Kasahara, Y; Namiki, T; Ogawa, K; Okamoto, H; Terasawa, K; Ueda, K, 2011)
"Diazepam-reduced experimental anxiety was paralleled by antinociceptive effects."	3.76	Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2010)
"Eight right-handed male volunteers underwent fMRI combined with a thermal pain conditioning paradigm and midazolam (30 mug/kg) or saline administration on different occasions, with order randomized across volunteers."	3.74	The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. ( Lujan, BJ; Peskett, GD; Rogers, R; Schweinhardt, P; Tracey, I; Wise, RG, 2007)
"We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam."	3.74	Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008)
" The role of factors with anxiogenic properties produced during inflammation, which may modify diazepam and buspirone effects, is discussed."	3.73	Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005)
"Seizures associated with the intravenous administration of codeine phosphate have not been extensively reported in the literature, and special precautions for using the parenteral route for this drug have been vague and limited."	3.71	Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001)
"We investigated the effects of diazepam (DZ) on a well-known pattern of brain regions activated by cold, tonic pain stimuli."	3.71	Diazepam effects on the cerebral responses to tonic pain: a SPET study. ( Cruccu, G; Di Legge, S; Di Piero, V; Ferracuti, S; Lenzi, GL; Pantano, P; Sabatini, U; Tombari, D, 2001)
"The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined."	3.69	Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994)
" For unanesthetized tubes the mean pain rating depended on the dose of diazepam and fentanyl given to the patient (p less than ."	3.65	Laparoscopic tubal clip sterilization under local anesthesia. ( Edelman, DA; Fishburne, JI; Hulka, JF; Mercer, JP; Omran, KF, 1974)
"Diazepam and midazolam were equivalent as judged by sedation, recovery time, patient tolerance, and ease of examination."	2.69	Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. ( Gevers, AM; Hendrickx, A; Macken, E; Rutgeerts, P, 1998)
"Pain was rated on visual analogue scales before, during, and after treatment."	2.67	A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. ( Eriksson, SV; Lundeberg, T; Thomas, M, 1991)
"Midazolam is a recently introduced benzodiazepine with a half life of 1-4 hours."	2.66	A comparison of midazolam and diazepam for sedation during locoregional anesthesia. ( Donadoni, R; Herregods, L; Mortier, E; Rolly, G, 1987)
"No pain was experienced by patients receiving thiopentone."	2.65	Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia. ( Aromaa, U; Korttila, K; Tammisto, T, 1979)
"The diazepam was dissolved in cremophor and this reduced the pain of intravenous injection of the diazepam."	2.64	Intravenous sedation and regional analgesia. ( Gjessing, J; Tomlin, PJ, 1977)
" The combination of diclofenac sodium and metamizole sodium is acceptable, although, at a lower dosage of metamizole, the duration of analgesia is shortened."	2.46	Evidence-based intravenous pain treatment with analgesic infusion regimens. ( Cihal, P; Kamyar, MR; Lemmens-Gruber, R; Nemec, K; Timin, E, 2010)
"Pain is a common and debilitating symptom of inflammatory bowel disease (IBD)."	1.72	Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. ( Gold, MS; Loeza-Alcocer, E, 2022)
"Diazepam treatment alone did not produce significant antinociception."	1.56	Effects of oxycodone and diazepam alone and in combination on operant nociception. ( Kangas, BD; Leonard, MZ, 2020)
"Pain is the most common reason a patient sees a physician."	1.40	Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014)
"Intratracheal suctioning evoked significant changes in some physiological and behavioral parameters."	1.38	Assessment of pain in sedated and mechanically ventilated patients: an observational study. ( Hamers, JP; Hantikainen, V; Jakob, SM; Jeitziner, MM; Rohrer, O; Schwendimann, R, 2012)
"CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: (1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), (2) a decrease in number of central squares visited in the open field (OF), and (3) a reduction in active social interactions in the social interaction test (SI)."	1.38	Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. ( Beaudet, N; Beaudry, H; Bergeron, J; Bérubé, P; Drolet, G; Gendron, L; Parent, AJ; Sarret, P, 2012)
"Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production."	1.37	Antinociceptive properties of bergenin. ( Couto, RD; David, JM; David, JP; de Lima, FO; de Oliveira, CM; Nonato, FR; Soares, MB; Villarreal, CF, 2011)
"This is a case report of a CPP treated by a pain physician."	1.35	Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009)
"Diazepam or yohimbine were administered 15 min before uric acid and the ability of the rat to use the injured hind limb was recorded."	1.33	Influence of pharmacologically-induced experimental anxiety on nociception and antinociception in rats. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2006)
"Midazolam 2."	1.28	[The effects of pentazocine, diazepam and midazolam in patients to reduce the uncomfortable feeling during epidural block procedure]. ( Kasaba, T, 1992)
"Diazepam (3 mg/kg) was followed by eating during the 1st hour after administration in non-food-deprived rats and a reduction in the behaviour triggered by a mild tail-pinch 90 min after drug administration."	1.28	Effect of diazepam on behaviour and associated changes in ascorbate concentration in rat brain areas: striatum, n. accumbens and hippocampus. ( Boutelle, MG; Fillenz, M; Svensson, L, 1990)
"The authors consider endotracheal narcosis with nitrous oxide combined with fractional injections of phentanyl and seduxen of phentanyl and droperidol to be a method of choice."	1.26	[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. ( Korzh, OB; Timchuk, ID, 1979)
"Pain was positively associated with 1) age of 15 years or less, 2) with gestation of less than 7 weeks or more than 12 and with dilatation on a curvilnear basis, and 3) with patient fear."	1.26	Pain of first-trimester abortion: its quantification and relations with other variables. ( Chirchirillo, L; McCarthy, MJ; Smith, GM; Stubblefield, PG, 1979)
"The adverse effects in a series of 50 lumbar myelographies with Amipaque were compared with those in a corresponding series, examined with Dimer-X."	1.26	Adverse effects of lumbar myelography with amipaque and dimer-X. ( Irstam, L; Selldén, U, 1976)
"Early detection and treatment of drug abuse should minimize some of the difficulties involved in management of treatment-resistive patients with chronic pain."	1.26	Drug abuse and dependency in patients with chronic pain. ( Finlayson, RE; Maruta, T; Swanson, DW, 1979)
"This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally."	1.25	Myofascial pain dysfunction syndrome involving tumor metastasis. Case report. ( Butler, JH, 1975)

Research

Studies (242)

Authors

Clinical Trials (17)

Trial Overview

Trial Outcomes

Length of Longest Piece

Portal Triads Number (Mean)

Portal Triads Quantity (Median)

Post-processing Aggregate Specimen Length (ASL)

Timeframe	Studies, this research(%)	All Research%
pre-1990	152 (62.81)	18.7374
1990's	36 (14.88)	18.2507
2000's	26 (10.74)	29.6817
2010's	24 (9.92)	24.3611
2020's	4 (1.65)	2.80

Authors	Studies
Liu, H	1
Altenbach, RJ	1
Carr, TL	1
Chandran, P	1
Hsieh, GC	1
Lewis, LG	1
Manelli, AM	1
Milicic, I	1
Marsh, KC	1
Miller, TR	1
Strakhova, MI	1
Vortherms, TA	1
Wakefield, BD	1
Wetter, JM	1
Witte, DG	1
Honore, P	1
Esbenshade, TA	1
Brioni, JD	1
Cowart, MD	1
de Oliveira, CM	1
Nonato, FR	1
de Lima, FO	1
Couto, RD	1
David, JP	1
David, JM	1
Soares, MB	2
Villarreal, CF	3
Guerrini, G	1
Ciciani, G	1
Bruni, F	1
Selleri, S	1
Martini, C	1
Daniele, S	1
Ghelardini, C	1
Di Cesare Mannelli, L	1
Costanzo, A	1
Gama, KB	1
Quintans, JS	1
Antoniolli, AR	1
Quintans-Júnior, LJ	1
Santana, WA	1
Branco, A	1
Tripathi, P	1
Tripathi, AC	1
Chawla, V	1
Saraf, SK	1
Lima, Mda S	1
Evangelista, AF	1
Santos, GG	1
Ribeiro, IM	1
Tomassini, TC	1
Pereira Soares, MB	1
Loeza-Alcocer, E	1
Gold, MS	1
Ng, DYT	1
Lo, A	1
So, EWS	1
Wong, GCY	1
Li, RHW	1
Wong, YY	1
Ng, EHY	1
Leonard, MZ	1
Kangas, BD	1
Diester, CM	1
Santos, EJ	1
Moerke, MJ	2
Negus, SS	2
Carter, C	1
Viveash, S	1
Hang, MTH	1
Smith, BE	1
Keck, C	1
Keshavarzian, A	1
Sedghi, S	1
Li, G	1
Golani, LK	1
Cook, J	1
Okamoto, M	1
Takahagi, S	1
Kamegashira, A	1
Yanase, Y	1
Hide, M	1
Li, R	1
Ruckle, HC	1
Creech, JD	1
Culpepper, DJ	1
Lightfoot, MA	1
Alsyouf, M	1
Nicolay, L	1
Jellison, F	1
Baldwin, DD	1
Ralvenius, WT	1
Benke, D	1
Acuña, MA	1
Rudolph, U	2
Zeilhofer, HU	2
Khaziakhmetova, VN	1
Luchai, KV	1
Ziganshina, LE	1
Gould, SA	1
Doods, H	1
Lamla, T	1
Pekcec, A	1
Novy, DM	1
Ritter, LM	1
McNeill, J	1
Fishbain, DA	1
Lewis, JE	1
Gao, J	1
Cole, B	1
Rosomoff, RS	1
Nemec, K	1
Cihal, P	1
Timin, E	1
Kamyar, MR	1
Lemmens-Gruber, R	1
Jiménez-Velázquez, G	2
López-Muñoz, FJ	3
Fernández-Guasti, A	3
Quintans, LJ	1
Silva, DA	1
Siqueira, JS	1
Araújo, AA	1
Barreto, RS	1
Bonjardim, LR	1
Desantana, JM	1
De Lucca, W	1
Souza, MF	1
Gutierrez, SJ	1
Barbosa-Filho, JM	1
Santana-Filho, VJ	1
Araújo, DA	1
Almeida, RN	1
Ueda, K	1
Namiki, T	1
Kasahara, Y	1
Chino, A	1
Okamoto, H	1
Ogawa, K	1
Terasawa, K	1
Navarte, DA	1
Rosset-Llobet, J	1
Kramskay, R	2
Tansky, A	1
Eisenberg, E	2
Veitsman, E	2
Baruch, Y	2
Parent, AJ	1
Beaudet, N	1
Beaudry, H	1
Bergeron, J	1
Bérubé, P	1
Drolet, G	1
Sarret, P	1
Gendron, L	1
Jeitziner, MM	1
Schwendimann, R	1
Hamers, JP	1
Rohrer, O	1
Hantikainen, V	1
Jakob, SM	1
Casarrubea, M	1
Sorbera, F	1
Santangelo, A	1
Crescimanno, G	1
Richards, BL	1
Whittle, SL	1
van der Heijde, DM	1
Buchbinder, R	1
Hansen, RR	1
Erichsen, HK	1
Brown, DT	1
Mirza, NR	1
Munro, G	1
Lok, IH	1
Chan, MT	1
Chan, DL	1
Cheung, LP	1
Haines, CJ	1
Yuen, PM	1
Majedi, H	1
Rabiee, M	1
Khan, ZH	2
Hassannasab, B	1
Konopniki, M	1
Gaitini, D	1
CAZORT, RJ	1
TARPLEY, EL	1
WOODROW, IH	1
MCGIVNEY, JQ	1
CLEVELAND, BR	1
KOENIGSTEIN, RP	1
KRAMMER, H	1
Nielsen, AN	1
Mathiesen, C	1
Blackburn-Munro, G	1
Khosravi, MB	1
Azemati, S	1
Azemati, M	1
Khosravi, A	1
Reyes, R	1
Martínez-Mota, L	1
Movafegh, A	1
Gharehdaghi, FA	1
Shoeibi, G	1
Ding, HK	1
Shum, FW	1
Ko, SW	1
Zhuo, M	1
Suaudeau, C	1
do-Rego, JC	1
Costentin, J	1
Narita, M	1
Kaneko, C	1
Miyoshi, K	1
Nagumo, Y	1
Kuzumaki, N	1
Nakajima, M	1
Nanjo, K	1
Matsuzawa, K	1
Yamazaki, M	1
Suzuki, T	1
Kenunen, OG	1
Prakh'e, IV	1
Kozlovskii, VL	1
Kumar, A	1
Kulkarni, SK	1
Meagher, LJ	1
McKay, D	1
Herkes, GK	1
Needham, M	1
Wan Hazmy, CH	1
Maizuliana, SH	1
Mastura, MT	1
Norazlina, M	1
Wise, RG	1
Lujan, BJ	1
Schweinhardt, P	1
Peskett, GD	1
Rogers, R	1
Tracey, I	1
Ng, CL	1
Knabl, J	1
Witschi, R	1
Hösl, K	1
Reinold, H	1
Zeilhofer, UB	1
Ahmadi, S	1
Brockhaus, J	1
Sergejeva, M	1
Hess, A	1
Brune, K	1
Fritschy, JM	1
Möhler, H	1
Suarez-Roca, H	1
Leal, L	1
Silva, JA	1
Pinerua-Shuhaibar, L	1
Quintero, L	1
Babenerd, J	2
Westermann, K	2
McGowan, WA	1
Dundee, JW	3
Clarke, RS	1
Howard, PJ	1
Jensen, S	1
Hüttel, MS	2
Schou Olesen, A	2
McLeod, JG	1
Chance, WT	1
Corli, O	1
Roma, G	1
Bacchini, M	1
Battagliarin, G	1
Di Piazza, D	1
Brambilla, C	1
Grossi, E	1
Jakoubek, B	2
Kryshanovskiĭ, GN	1
Grafova, VN	1
Danilova, EI	1
Levine, JD	1
Feldmesser, M	1
Tecott, L	1
Gordon, NC	1
Izdebski, K	1
Hollister, LE	1
Conley, FK	1
Britt, RH	1
Shuer, L	1
Lintin, DJ	1
Martin, DF	1
Tweedle, DE	1
Iriki, A	1
Ikezono, E	1
Toda, K	1
Tanaka, H	1
Bahar, M	1
McAteer, E	1
Briggs, LP	1
Helmers, JH	1
Adam, AA	1
Giezen, J	1
Fishburne, JI	2
Wüster, M	1
Duka, T	1
Herz, A	1
Bullimore, DW	1
Haas, S	1
Emrich, HM	1
Beckmann, H	1
Kirchner, P	1
Kromann, B	1
Jørgensen, J	1
Larsen, S	1
Gracely, RH	4
Dubner, R	4
McGrath, PA	1
Havasi, G	1
Gintautas, J	1
Warren, PR	1
Havasi, I	1
Thomas, ET	1
Racz, GB	1
Menon, MK	1
Clark, WG	1
Vivonia, C	1
Johansson, BW	1
Thiébot, MH	1
Jobert, A	1
Soubrié, P	1
Thakuria, SP	1
Rahman, AF	2
Takahashi, M	2
Kaneto, H	2
Strauss, A	1
Van den Berg, AA	1
Prabhu, NV	1
Thürauf, N	1
Ditterich, W	1
Kobal, G	1
Xiao-Jun, X	1
Jing-Xia, H	1
Seiger, Å	1
Hughes, J	1
Hökfelt, T	1
Wiesenfeld-Hallin, Z	1
Simşek, S	1
Akyüz, S	1
Sener, G	1
Göker, K	1
Güvener, O	1
Helmstetter, FJ	2
Guha, A	1
Das, BN	1
Sengupta, S	1
Das, BK	1
Dellemijn, PL	1
Vanneste, JA	1
Canto de Souza, A	1
Nunes de Souza, RL	1
Péla, IR	1
Graeff, FG	1
Kondo, M	1
Kagawa, T	1
Horikawa, Y	1
Ohnishi, H	1
Obara, H	1
Macken, E	1
Gevers, AM	1
Hendrickx, A	1
Rutgeerts, P	1
Boezaart, AP	1
Berry, RA	1
Laubscher, JJ	1
Nell, ML	1
Kollarits, CR	1
Jaweed, S	1
Kollarits, FJ	1
Nicolodi, M	1
Mamiya, H	1
Noma, T	1
Fukuda, K	1
Kasahara, M	1
Ichinohe, T	1
Kaneko, Y	1
Larson, JS	1
Lunn, JJ	1
Kang, W	1
Wilson, SP	1
Wilson, MA	1
Riaño Galán, I	1
Mayoral González, B	1
Solís Sánchez, G	1
Orejas Rodríguez-Arango, G	1
Málaga Guerrero, S	1
Tornos, MP	1
Sáenz, MT	1
García, MD	1
Fernández, MA	1
Jenck, F	1
Wichmann, J	1
Dautzenberg, FM	1
Moreau, JL	1
Ouagazzal, AM	1
Martin, JR	1
Lundstrom, K	1
Cesura, AM	1
Poli, SM	1
Roever, S	1
Kolczewski, S	1
Adam, G	1
Kilpatrick, G	1
Zolezzi, M	1
Al Mohaimeed, SA	1
Di Piero, V	1
Ferracuti, S	1
Sabatini, U	1
Tombari, D	1
Di Legge, S	1
Pantano, P	1
Cruccu, G	1
Lenzi, GL	1
Nemmani, KV	1
Ramarao, P	1
Graham, CW	1
Pagano, RR	1
Conner, JT	1
Fowler, AW	1
Taclob, L	1
Needle, M	1
Schmidt, KR	1
Pfeifer, KJ	1
Welter, H	1
Ingrisch, H	1
Heyde, G	1
Nikolaev, VI	1
Marusov, IV	1
Gelfman, SS	1
Driscoll, EJ	1
Wirdzek, PR	1
Sweet, JB	1
Butler, DP	1
Stern, JA	1
Brown, M	1
Ulett, GA	1
Sletten, I	1
Gjessing, J	1
Tomlin, PJ	1
Davies, JM	1
Rosen, M	1
Rollman, GB	1
Eisenberg, RL	1
Mani, RL	1
Hedgcock, MW	1
Lineberry, CG	1
Kulics, AT	1
Maruta, T	1
Swanson, DW	1
Finlayson, RE	1
Korzh, OB	2
Timchuk, ID	1
Smith, GM	1
Stubblefield, PG	1
Chirchirillo, L	1
McCarthy, MJ	1
Yang, JC	1
Clark, WC	1
Ngai, SH	1
Berkowitz, BA	1
Spector, S	1
Korttila, K	2
Tammisto, T	1
Aromaa, U	1
Carlos, R	1
Innerarity, S	1
Naidu, KR	1
Tröltzsch, M	1
Fischer, P	1
Cormani, AM	1
Salmoiraghi, ML	1
Tiengo, M	1
Abrams, RS	1
McGrath, P	1
Seppälä, T	1
von Dardel, O	1
Mebius, C	1
Mossberg, T	1
Raft, D	2
Gregg, J	1
Ghia, J	1
Harris, L	1
Pavlík, A	1
Kraus, M	1
Rehulka, J	1
Siebke, H	1
Ellertsen, BB	1
Lind, B	1
Marbach, JJ	1
Dworkin, SF	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641]		61 participants (Actual)	Interventional	2016-07-31	Completed
Smart Pain Assesment Tool Based on Internet of Things[NCT03061240]		58 participants (Actual)	Interventional	2017-11-20	Completed
19-Gauge Fine Needle Aspirate (FNA) Versus 19-Gauge Fine Needle Biopsy (FNB) Needles for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB): A Randomized Prospective Trial[NCT03408171]		40 participants (Actual)	Interventional	2017-10-02	Completed
19 Versus 22-Gauge Fine Needle Biopsy (FNB) Needles for Endoscopic Ultrasound Guided Liver Biopsy (EUS-LB): A Prospective Pilot Study[NCT02967991]		20 participants (Actual)	Interventional	2016-08-31	Completed
Comparison of Pain Scores Between Endoscopic Ultrasound (EUS)-Guided Liver Biopsy and Percutaneous Liver Biopsy[NCT02947516]		0 participants (Actual)	Interventional	2017-01-31	Withdrawn (stopped due to Funding n/a)
Contribution of Hypnosis in Guided Hepatic Biopsy[NCT05413174]		70 participants (Actual)	Interventional	2022-09-29	Completed
Intravenous Injection of Diazepam at the Beginning of Active Phase of Labor[NCT02232035]	Phase 2	400 participants (Anticipated)	Interventional	2014-09-30	Not yet recruiting
An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366]	Phase 4	121 participants (Actual)	Interventional	2010-04-30	Completed
Auricular Acupuncture as Adjunct for Pain Management During First Trimester Uterine Aspiration.[NCT03391986]		153 participants (Actual)	Interventional	2017-09-09	Completed
Pain Measurement in Healthy Volunteers[NCT00001597]		40 participants	Observational	1997-03-31	Completed
Postoperative Pain Control in Extracapsular Hip Fracture Patients: Fascia Iliaca Compartment Block Versus Fracture Block[NCT04335461]	Early Phase 1	0 participants (Actual)	Interventional	2021-08-05	Withdrawn (stopped due to Study was withdrawn. Study expired in IRB system and no patients enrolled as per institutional CTMS and IRB systems. Primary and Study Completion Dates reflect date IRB approval expired.)
"Comparison of Ultrasound-guided Hematoma Block and Blind Hematoma Block for Analgesia in Distal Radius Fractures"[NCT02346929]		115 participants (Anticipated)	Interventional	2014-08-31	Recruiting
Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain[NCT04744883]	Early Phase 1	240 participants (Anticipated)	Interventional	2020-08-10	Recruiting
Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid Function[NCT02469077]		117 participants (Actual)	Interventional	2015-08-31	Completed
Acupuncture for Vasectomy Pre-procedural Anxiety and Pain Control in the Primary Care Setting: A Randomized Comparative Effectiveness Trial[NCT03938415]		85 participants (Anticipated)	Interventional	2019-06-01	Recruiting
Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227]	Phase 4	748 participants	Interventional	2001-09-30	Completed
Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure During Congenital Pulmonary Stenosis Balloon Dilatation[NCT05582213]		40 participants (Actual)	Interventional	2022-10-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mm (Median)
19-gauge FNA Needle	32.3
19-gauge FNB Needle	30.2

Intervention	Portal Triads (Mean)
19-gauge FNA Needle	18.1
19-gauge FNB Needle	42.6

Intervention	Complete number of portal triads (Median)
19-gauge FNA Needle	16.5
19-gauge FNB Needle	38

Post-processing Aggregate specimen length (ASL) measured in centimeter (NCT03408171)
Timeframe: 3-5 days

Post-processing Length of the Longest Piece (LLP)

Intervention	centimeter (Mean)
19-gauge FNA Needle	11.4
19-gauge FNB Needle	15.32

Post-processing Length of the longest piece (LLP) measured in centimeter (NCT03408171)
Timeframe: 3-5 days

Pre-processing Aggregate Specimen Length (ASL)

Intervention	centimeter (Mean)
19-gauge FNA Needle	1.05
19-gauge FNB Needle	1.78

Pre-processing Aggregate specimen length (ASL) measured in centimeter (NCT03408171)
Timeframe: 3-5 days

Pre-processing Length of the Longest Piece (LLP)

Intervention	centimeter (Mean)
19-gauge FNA Needle	10.89
19-gauge FNB Needle	15.78

Pre-processing Length of the longest piece (LLP) measured in centimeter (NCT03408171)
Timeframe: up to 5 days

Specimen Quality for Histologic Diagnosis

Intervention	centimeter (Mean)
19-gauge FNA Needle	1.47
19-gauge FNB Needle	2.09

Number of cases for which a histologic diagnosis could be made based upon the amount of tissue obtained with the needle. (NCT03408171)
Timeframe: 3-5 days

No. of Fragments > 9 mm, Mean (SD)

Intervention	Participants (Count of Participants)
19-gauge FNA Needle	20
19-gauge FNB Needle	20

No. of fragments > 9 mm, mean (SD) Pre-processing Post-processing (NCT03408171)
Timeframe: 3-5 days

Aggregate Specimen Length Under Histologic Examination

Intervention	Number of Fragments (Mean)
	Pre-processing	Post-processing
19-gauge FNA Needle	3.5	1.1
19-gauge FNB Needle	7.7	4.8

"Length of all the tissue (centimeters) by adding the sum of all pieces Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days

Length of the Longest Piece Under Histologic Examination

Intervention	cm for portal tracts of specimens (Mean)
19 Gauge FNA	76.5
22 Gauge FNB	66.9

"length of the longest tissue biopsy piece (centimeters) as measured by pathology Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days

Number of Portal Tracts (PT) in the Specimen (Total) Under Histologic Examination

Intervention	mean cm for portal tracts of specimens (Mean)
19 Gauge FNA	13.2
22 Gauge FNB	10.8

"Number of portal tracts (PT) in the specimen (total) under histologic examination Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days

Number of Specimens for Which a Histologic Diagnosis Could be Made Based Upon the Amount of Tissue Obtained With the Needle

Intervention	mean portal tracts (Mean)
19 Gauge FNA	7.4
22 Gauge FNB	6.1

"Defined by total portal structures > 5 or length of the longest piece > 15 mm) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days

The Number of Patients Requiring Medical Care After Needle Biopsy

Intervention	specimens (Number)
19 Gauge FNA	17
22 Gauge FNB	14

"Patient requiring visit to healthcare center (emergency room, hospital, call to service) within time 7 days Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 Days

The Number of Patients With Pain 1 Day After Needle Biopsy

Intervention	Participants (Count of Participants)
Total Population	1

"Pain using Likert score 0-10 (10 worst) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 1 days

The Number of Patients With Pain 7 Day After Needle Biopsy

Intervention	Participants (Count of Participants)
Total Population	0

The Number of Patients With Visible Bleeding After Needle Biopsy

Intervention	Participants (Count of Participants)
Total Population	1

"Patient with blood visible from patient's mouth, rectum with a 2 gram drop in hemoglobin Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: 7 days

The Number of Specimens With a Visible Clot After Needle Biopsy

Intervention	Participants (Count of Participants)
Total Population	0

"Presence of visible clots in specimen (yes/no) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: Day of Procedure

The Number of Specimens With a Visible Core After Needle Biopsy

Intervention	specimens (Number)
19 Gauge FNA	4
22 Gauge FNB	1

"Presence of a visible core specimen (yes/no) Subjects underwent a left liver biopsy using a 19-gauge FNA needle, 22-gauge FNB needle, right liver biopsies also using the 19-gauge FNA and 22-gauge FNB.~FNA-fine needle aspiration FNB-fine needle biopsy" (NCT02967991)
Timeframe: Day of Procedure

Change in Visual Analog Scale for Pain (VAS Pain) Score - Placebo Versus Routine Care

Intervention	specimens (Number)
19 Gauge FNA	20
22 Gauge FNB	19

Measure effectiveness of placebo as an adjunct to ibuprofen and paracervical block for pain control during uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive placebo adhesives and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). (NCT03391986)
Timeframe: prior to the procedure (baseline), at the completion of the procedure (approximately 10 minutes later)

Percentage of Patients Rated Good or Very Good on Satisfaction Survey in Overall Care - Acupuncture Versus Routine Care

Intervention	score on a scale (Mean)
Placebo Adhesives	70.0
Routine Care	71.0

Using a satisfaction survey (investigator-developed, 6 questions, each question is graded on a scale of 1-5, 1 being very poor and 5 being very good) to measure effectiveness of auricular acupuncture for improving satisfaction. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 5-10 minutes)

Visual Analog Scale for Pain (VAS Pain) Score - Acupuncture Versus Routine Care

Intervention	percentage of participants (Number)
Pyonex Needles	94
Routine Care	76

Measure effectiveness of auricular acupuncture as an adjunct to ibuprofen and paracervical block for pain control during first trimester uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive auricular acupuncture and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). The VAS has no sub-scales. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 10 minutes later)

Mean Change in 5-day Electronic Diary Ratings of Low Back Pain Intensity

Intervention	score on a scale (Mean)
Pyonex Needles	39.5
Routine Care	71.0

Mean change in 5-day electronic diary ratings of low back pain intensity from pre intervention baseline to post intervention. 9 point pain scale assessing pain intensity with 0 represents no pain and 8 represents worst possible pain. Positive values indicate reduced pain post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in McGill Pain Questionnaire-2 Total Chronic Back Pain Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	2.75	0.72
Normal Exercise (Control)	2.82	0.18

Mean change in McGill Pain Questionnaire-2 total chronic back pain ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-10 where 0 represents no pain and 10 represents most intense pain. Positive values indicate decreased back pain post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Drug Effects, Liking, and Take Again (DELTA) -Drug Effect Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	2.66	1.60
Normal Exercise (Control)	3.01	1.36

Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Drug Effect subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 1-5 where 1 represents no effect and 5 represents very strong effect. Positive values indicate decreased overall drug effects post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Drug Effects, Liking, and Take Again (DELTA) -Drug Liking Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	2.72	0.10
Normal Exercise (Control)	2.52	-0.12

Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Drug Liking subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-100 where 0 represents dislike a lot and 100 represents like a lot. Positive values indicate decreased drug liking post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Drug Effects, Liking, and Take Again (DELTA) -Take Again Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	52.03	4.13
Normal Exercise (Control)	52.89	1.04

Mean change in morphine condition Drug Effects, Liking, and Take Again (DELTA) -Take Again subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-100 where 0 represents definitely would not take again and 100 represents definitely would take again. Positive values indicate decreased desire to take the drug again post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Visual Analog Scale (VAS) Opioid Effects - Unpleasantness Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	54.49	4.40
Normal Exercise (Control)	55.04	1.70

Mean change in morphine condition VAS Opioid Effects - Unpleasantness subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 represents no unpleasantness and 300 represents most unpleasantness possible. Positive values indicate decreased unpleasantness post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Visual Analog Scale (VAS) Opioid Effects Scale-Euphoria Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	33.58	-3.21
Normal Exercise (Control)	16.52	1.86

Mean change in morphine condition VAS Opioid Effects-Euphoria subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 means no euphoria and 300 means most euphoria possible. Positive values indicate decreased euphoria post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Morphine Condition Visual Analog Scale (VAS) Opioid Effects Scale-Sedation Subscale Ratings

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	100.60	3.19
Normal Exercise (Control)	108.24	0.75

Mean change in morphine condition VAS Opioid Effects-Sedation subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. The score ranges from 0-300 where 0 means no sedation and 300 means most sedation possible. Positive values indicate decreased sedation post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean Change in Placebo Condition Ratings of Acute Thermal Pain Intensity on the McGill Pain Questionnaire-Short Form

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	66.58	12.89
Normal Exercise (Control)	30.63	-9.95

Mean change in placebo condition ratings of acute thermal pain intensity using the McGill Pain Questionnaire-Short Form on 3 testing days at baseline (per intervention) and post intervention. The score ranges from 0-33 where 0 represents no pain and 33 represents most intense pain. Positive change values indicate decreased pain responsiveness post intervention. (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)

Mean Change in Positive and Negative Affect Scale-Negative Affect Subscale Ratings.

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	10.23	0.45
Normal Exercise (Control)	7.83	-2.14

Mean change in Positive and Negative Affect Scale-Negative Affect subscale ratings on 3 testing days at baseline (pre intervention) and post intervention. . Scale ratings range from 10 to 50 where 10 represents lowest negative affect possible and 50 represents highest negative affect possible. Positive values indicate decreased negative affect post intervention. (NCT02469077)
Timeframe: At pre intervention baseline and again post-intervention (an expected average of 6 weeks later)

Mean of the Change in Morphine Dosage (in mg) Required to Achieve 25% Reduction in Thermal Evoked Pain Responses Relative to Baseline (Pre-intervention) Placebo Condition Responses

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	16.38	0.45
Normal Exercise (Control)	15.43	-2.14

"At a laboratory testing day pre and post intervention each participant received morphine sulphate (0.3mg/kg in 20ml saline vehicle initially, followed by 3 incremental doses of 0.02 mg/kg each with testing for thermal evoked pain response. Weight adjusted dosing was used by multiplying the weight of each patient in kg by 0.3mg (dose 1 only) or by .02mg (doses 2-4), with all doses infused in 20mL saline vehicle.~Mean of the change in morphine dosage required to achieve 25 % reduction in thermal evoked pain responses on testing day at baseline (pre-intervention) and post intervention. Positive values for the change in the mean between pre and post intervention indicated decreased morphine requirements post intervention." (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)

Mean Within-participant Changes From Pre- to Post-intervention in Opioid Blockade Effects (Within-participant Difference Between Naloxone and Placebo Conditions) for McGill Pain Questionnaire-2 Total Ratings of Back Pain.

Intervention	mg (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	4.17	-1.62
Normal Exercise (Control)	6.34	0.92

"Between-participant (aerobic exercise vs. control group) comparison of mean changes from pre- to post-intervention in opioid blockade effects for McGill Pain Questionnaire-2 Total ratings of back pain based on 3 laboratory testing days at baseline (pre intervention) and post intervention. The score ranges from 0-10 where 0 represents no pain and 10 represents most intense pain. Positive values indicate increased endogenous opioid analgesia post intervention.~This measure will test the effects of the exercise (versus control) intervention on clinical outcomes as indexed by changes in opioid blockade effects (the difference in laboratory evoked pain response evoked between placebo and naloxone drug conditions).~This is a mixed within-between subject design. Per the study protocol, the intent of outcome measures 4 and 6 was to capture opioid blockade effects (within-participant placebo-naloxone condition difference scores) at both the pre- and post-intervention lab assessments, an" (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)

Mean Within-participant Changes From Pre- to Post-intervention in Opioid Blockade Effects (Within-participant Difference Between Naloxone and Placebo Conditions) for Ratings of Acute Thermal Pain Intensity on the McGill Pain Questionnaire-Short Form

Intervention	units on a scale (Mean)
	Baseline (pre intervention)	Change after 6 week intervention period
6 Week Aerobic Exercise Intervention	0.11	-0.12
Normal Exercise (Control)	0.18	-0.24

"Between-participant (aerobic exercise vs. control group) comparison of mean changes from pre- to post-intervention in opioid blockade effects for ratings of acute thermal pain intensity on the McGill Pain Questionnaire-Short Form based on 3 laboratory testing days at baseline (pre-intervention) and post intervention. The score ranges from 0-33 where 0 represents no pain and 33 represents more intense pain. Positive values indicate increased endogenous opioid analgesia post intervention.~This measure will test for endogenous opioid mechanisms of the exercise (versus control) intervention as indexed by changes in opioid blockade effects (the difference in laboratory evoked pain response evoked between placebo and naloxone drug conditions).~This is a mixed within-between subject design. Per the study protocol, the intent of outcome measures 4 and 6 was to capture opioid blockade effects (within-participant placebo-naloxone condition difference scores) at both the pre- and post-in" (NCT02469077)
Timeframe: At pre-intervention baseline laboratory assessment and again post-intervention (an expected average of 6 weeks later)

Article	Year
A primer of ethical issues involving opioid therapy for chronic nonmalignant pain in a multidisciplinary setting. Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:2 Topics: Analgesics, Opioid; Chickenpox; Cholecystectomy; Chronic Disease; Diazepam; Facial Pain; Female; Her	2009
Evidence-based intravenous pain treatment with analgesic infusion regimens. Arzneimittel-Forschung, 2010, Volume: 60, Issue:5 Topics: Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Diazepam; Diclofenac; Drug	2010
The efficacy and safety of muscle relaxants in inflammatory arthritis: a Cochrane systematic review. The Journal of rheumatology. Supplement, 2012, Volume: 90 Topics: Analgesics; Arthritis, Rheumatoid; Diazepam; Drug Therapy, Combination; Humans; Muscle Relaxants, Ce	2012
Levator ani syndrome - a case study and literature review. Australian family physician, 2007, Volume: 36, Issue:6 Topics: Acetaminophen; Adult; Anal Canal; Analgesics, Non-Narcotic; Anus Diseases; Baths; Diazepam; Family P	2007
Autoanalgesia: opiate and non-opiate mechanisms. Neuroscience and biobehavioral reviews, 1980,Spring, Volume: 4, Issue:1 Topics: Animals; Central Nervous System; Conditioning, Classical; Diazepam; Electroshock; Emotions; Endorphi	1980
Systemic analgesia during labor. Clinics in perinatology, 1982, Volume: 9, Issue:1 Topics: Acid-Base Equilibrium; Analgesics; Animals; Child Behavior; Diazepam; Female; Fentanyl; Fetal Heart;	1982
Comparing drugs for short-term sedation. Contemporary internal medicine, 1994, Volume: 6, Issue:12 Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam;	1994
Signal detection theory measurement of pain: a review and critique. Pain, 1977, Volume: 3, Issue:3 Topics: Acupuncture Therapy; Age Factors; Diazepam; Discrimination, Psychological; Electric Stimulation; Fem	1977
Hyperalgesia induced by emotional stress in the rat: an experimental animal model of human anxiogenic hyperalgesia. Annals of the New York Academy of Sciences, 1986, Volume: 467 Topics: Analgesia; Animals; Anxiety; Diazepam; Disease Models, Animal; Emotions; Humans; Hypophysectomy; Pai	1986
Advances in neurology. The Practitioner, 1968, Volume: 201, Issue:204 Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra	1968
Pain control and patient management in dentistry--a review of current intravenous technics. Journal of the American Dental Association (1939), 1970, Volume: 80, Issue:1 Topics: Anesthesia, Intravenous; Dentistry; Diazepam; Humans; Injections, Intravenous; Medical History Takin	1970

Article	Year
A randomized controlled study of acupuncture for pain relief during first trimester surgical termination of pregnancy performed under local analgesia. Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2022, Volume: 40, Issue:3 Topics: Acupuncture Therapy; Analgesia; Diazepam; Female; Humans; Pain; Pregnancy; Pregnancy Trimester, Firs	2022
A prospective, randomized, controlled trial assessing diazepam to reduce perception and recall of pain during transrectal ultrasonography-guided biopsy of the prostate. Journal of endourology, 2014, Volume: 28, Issue:7 Topics: Aged; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Endoscopic Ultrasound-Guided Fine Needle A	2014
Prophylactic analgesia before percutaneous liver biopsy: a clinical comparative study. European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:9 Topics: Adult; Analgesia; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Biopsy, Needle; Diazepam; Female	2011
A prospective randomized trial comparing patient-controlled sedation using propofol and alfentanil and physician-administered sedation using diazepam and pethidine during transvaginal ultrasound-guided oocyte retrieval. Human reproduction (Oxford, England), 2002, Volume: 17, Issue:8 Topics: Adult; Alfentanil; Analgesia, Patient-Controlled; Analgesics, Opioid; Conscious Sedation; Diazepam;	2002
A comparison of metoclopramide and lidocaine for preventing pain on injection of diazepam. Anesthesia and analgesia, 2002, Volume: 95, Issue:5 Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Diazepam; Double-Blind Method; Female; Human	2002
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
Prevalence and characteristics of pain induced by percutaneous liver biopsy. Anesthesia and analgesia, 2003, Volume: 96, Issue:5 Topics: Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Biopsy; Diazepam; Female; Humans; Lid	2003
The effect of ketamine and fentanyl in reducing the pain of diazepam injection. Middle East journal of anaesthesiology, 2004, Volume: 17, Issue:6 Topics: Adolescent; Adult; Analgesics; Anesthetics, Intravenous; Diazepam; Double-Blind Method; Fentanyl; Hu	2004
Dexamethasone dose attenuates pain on injection following diazepam hydrochloride. Anesthesia and analgesia, 2005, Volume: 100, Issue:5 Topics: Adult; Dexamethasone; Diazepam; Double-Blind Method; Humans; Injections; Male; Metoclopramide; Middl	2005
Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in patients. British journal of anaesthesia, 1980, Volume: 52, Issue:4 Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind M	1980
Venous complications after i.v. administration of Diazemuls (diazepam) and Dormicum (midazolam). British journal of anaesthesia, 1981, Volume: 53, Issue:10 Topics: Adult; Aged; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Female; Humans; Injections, Intravenous	1981
Double-blind placebo-controlled trial of baclofen, alone and in combination, in patients undergoing voluntary abortion. Clinical therapeutics, 1984, Volume: 6, Issue:6 Topics: Abortion, Induced; Adolescent; Adult; Baclofen; Clinical Trials as Topic; Diazepam; Dilatation and C	1984
Venous complications of two diazepam preparations related to size of vein. British journal of anaesthesia, 1983, Volume: 55, Issue:8 Topics: Arm; Diazepam; Endoscopy; Hand; Humans; Pain; Thrombophlebitis; Veins	1983
Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl. Acta anaesthesiologica Belgica, 1981, Volume: 32, Issue:2 Topics: Adolescent; Adult; Aged; Anesthesia; Clinical Trials as Topic; Diazepam; Double-Blind Method; Droper	1981
A comparison of the incidence of injection pain with two different diazepam formulations--Valium and Diazemuls. Clinical therapeutics, 1982, Volume: 4, Issue:5 Topics: Diazepam; Drug Evaluation; Emulsions; Endoscopy; Humans; Injections, Intravenous; Pain; Solutions	1982
Analgesic and euphoric effects of high dose diazepam in schizophrenia. Neuropsychobiology, 1982, Volume: 8, Issue:3 Topics: Adult; Analgesia; Diazepam; Endorphins; Euphoria; Female; Humans; Male; Middle Aged; Naloxone; Pain;	1982
A comparative study of cardioselective beta-blockade and diazepam in patients wtih acute myocardial infarction and tachycardia. Acta medica Scandinavica, 1980, Volume: 207, Issue:1-2 Topics: Age Factors; Aged; Blood Gas Analysis; Blood Pressure; Body Temperature; Diazepam; Female; Humans; M	1980
Local reactions to i.v. diazepam in three different formulations. British journal of anaesthesia, 1980, Volume: 52, Issue:6 Topics: Adult; Castor Oil; Diazepam; Emulsions; Glycerol; Humans; Infusions, Parenteral; Pain; Propylene Gly	1980
Rationalizing venepuncture pain: comparison of lignocaine injection, Butterfly (21 gauge and 23 gauge) and Venflon (20 gauge). Anaesthesia and intensive care, 1995, Volume: 23, Issue:2 Topics: Adolescent; Adult; Bloodletting; Catheterization, Peripheral; Diazepam; Equipment Design; Female; Hu	1995
Different sensitivity of pain-related chemosensory potentials evoked by stimulation with CO2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. British journal of clinical pharmacology, 1994, Volume: 38, Issue:6 Topics: Acoustic Stimulation; Adult; Carbon Dioxide; Chemoreceptor Cells; Cross-Over Studies; Dental Pulp; D	1994
Classification and premedication of uncooperative children. The Journal of Nihon University School of Dentistry, 1993, Volume: 35, Issue:1 Topics: Acepromazine; Attention; Child; Child Behavior; Child, Preschool; Cooperative Behavior; Dental Anxie	1993
Variation of serum potassium and creatinine phosphokinase levels in suxamethonium-induced muscle relaxation. Journal of the Indian Medical Association, 1996, Volume: 94, Issue:2 Topics: Adult; Anesthetics, Intravenous; Creatine Kinase; Diazepam; Drug Therapy, Combination; Female; Human	1996
Randomised double-blind active-placebo-controlled crossover trial of intravenous fentanyl in neuropathic pain. Lancet (London, England), 1997, Mar-15, Volume: 349, Issue:9054 Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Diazepam; Double-Blind Method; Female; Fentanyl	1997
[Influence of preanesthetic medication on the effect of a local anesthetic tape]. Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:9 Topics: Adjuvants, Anesthesia; Administration, Topical; Adult; Aged; Anesthetics, Local; Anti-Anxiety Agents	1997
Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. Gastrointestinal endoscopy, 1998, Volume: 47, Issue:1 Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Intravenous; Antidotes;	1998
Evaluation of anxiolysis and pain associated with combined peri- and retrobulbar eye block for cataract surgery. Journal of clinical anesthesia, 1998, Volume: 10, Issue:3 Topics: Aged; Alprazolam; Anesthesia, Local; Anesthetics, Local; Anti-Anxiety Agents; Anxiety; Bromazepam; B	1998
Painful and non-painful effects of low doses of morphine in migraine sufferers partly depend on excitatory amino acids and gamma-aminobutyric acid. International journal of clinical pharmacology research, 1998, Volume: 18, Issue:2 Topics: Adult; Cross-Over Studies; Diazepam; Double-Blind Method; Excitatory Amino Acids; gamma-Aminobutyric	1998
Pain following intravenous administration of sedative agents: a comparison of propofol with three benzodiazepines. Anesthesia progress, 1998,Winter, Volume: 45, Issue:1 Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Anesthetics, Local; Anti-Anxiety Agents; Cros	1998
Pain and clinical thrombophlebitis following intravenous diazepam and lorazepam. Anaesthesia, 1978, Volume: 33, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Metho	1978
A comparison of hypnosis, acupuncture, morphine, valium, aspirin, and placebo in the management of experimentally induced pain. Annals of the New York Academy of Sciences, 1977, Oct-07, Volume: 296 Topics: Acupuncture Therapy; Adolescent; Adult; Analgesia; Aspirin; Diazepam; Humans; Hypnosis; Male; Morphi	1977
Intravenous sedation and regional analgesia. Anaesthesia, 1977, Volume: 32, Issue:1 Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Clinical Trials as Topic; Diazepam; Female; Humans;	1977
Intramuscular diazepam in labour. A double-blind trial in multiparae. British journal of anaesthesia, 1977, Volume: 49, Issue:6 Topics: Clinical Trials as Topic; Diazepam; Female; Humans; Injections, Intramuscular; Labor, Obstetric; Mep	1977
Pain associated with peripheral angiography: is lidocaine effective? Radiology, 1978, Volume: 127, Issue:1 Topics: Aged; Angiography; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; Lidocain	1978
Comparison of etomidate in combination with fentanyl or diazepam, with thiopentone as an induction agent for general anaesthesia. British journal of anaesthesia, 1979, Volume: 51, Issue:12 Topics: Adult; Anesthesia, General; Diazepam; Etomidate; Fentanyl; Humans; Imidazoles; Middle Aged; Movement	1979
Effect of premedication on etomidate anaesthesia. British journal of anaesthesia, 1979, Volume: 51, Issue:12 Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Atropine; Diazepam; Etomidate; Fentanyl; Humans; I	1979
Diazepam in emulsion form for intravenous usage. Acta anaesthesiologica Scandinavica, 1976, Volume: 20, Issue:3 Topics: Adjuvants, Anesthesia; Clinical Trials as Topic; Diazepam; Drug Evaluation; Emulsions; Female; Human	1976
Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response. Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:1 Topics: Adolescent; Adult; Analgesics; Anxiety; Diazepam; Dronabinol; Heart Rate; Humans; Injections, Intrav	1977
Reactions to intravenous injections of diazepam. British journal of anaesthesia, 1976, Volume: 48, Issue:12 Topics: Diazepam; Humans; Injections, Intravenous; Pain; Solvents; Thrombophlebitis; Time Factors	1976
[Diazepam in obstetrics. A double-blind study on duration of labor, pain, Apgar score and complications]. Ugeskrift for laeger, 1975, Mar-24, Volume: 137, Issue:13 Topics: Apgar Score; Clinical Trials as Topic; Diazepam; Drug Evaluation; Female; Humans; Infant, Newborn; L	1975
Diazepam as a sedative in induced abortion. Acta obstetricia et gynecologica Scandinavica, 1975, Volume: 54, Issue:3 Topics: Abortion, Induced; Adolescent; Adult; Clinical Trials as Topic; Diazepam; Female; Humans; Middle Age	1975
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation. The Online journal of current clinical trials, 1992, Oct-01, Volume: Doc No 23 Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli	1992
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation. The Online journal of current clinical trials, 1992, Oct-01, Volume: Doc No 23 Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli	1992
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation. The Online journal of current clinical trials, 1992, Oct-01, Volume: Doc No 23 Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli	1992
Analgesia for the reduction of Colles fracture. A comparison of hematoma block and intravenous sedation. The Online journal of current clinical trials, 1992, Oct-01, Volume: Doc No 23 Topics: Adult; Analgesia; Anesthesia, Intravenous; Anesthesia, Local; Colles' Fracture; Diazepam; Double-Bli	1992
Interaction of diazepam and naloxone on acupuncture induced pain relief. The American journal of Chinese medicine, 1991, Volume: 19, Issue:1 Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa	1991
Interaction of diazepam and naloxone on acupuncture induced pain relief. The American journal of Chinese medicine, 1991, Volume: 19, Issue:1 Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa	1991
Interaction of diazepam and naloxone on acupuncture induced pain relief. The American journal of Chinese medicine, 1991, Volume: 19, Issue:1 Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa	1991
Interaction of diazepam and naloxone on acupuncture induced pain relief. The American journal of Chinese medicine, 1991, Volume: 19, Issue:1 Topics: Acupuncture Analgesia; Aged; Animals; Chronic Disease; Combined Modality Therapy; Diazepam; Electroa	1991
A comparative study of diazepam and acupuncture in patients with osteoarthritis pain: a placebo controlled study. The American journal of Chinese medicine, 1991, Volume: 19, Issue:2 Topics: Acupuncture Analgesia; Adult; Cervical Vertebrae; Chronic Disease; Diazepam; Humans; Middle Aged; Os	1991
An investigation of cognitive-behavior therapy combined with oral valium for children undergoing painful medical procedures. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1991, Volume: 10, Issue:5 Topics: Arousal; Bone Marrow Examination; Child; Child, Preschool; Cognitive Behavioral Therapy; Combined Mo	1991
Short report: sedation for upper gastrointestinal endoscopy--diazepam versus midazolam. Alimentary pharmacology & therapeutics, 1990, Volume: 4, Issue:4 Topics: Adolescent; Adult; Aged; Diazepam; Endoscopy, Gastrointestinal; Female; Humans; Male; Midazolam; Mid	1990
A stress inoculation program for parents whose children are undergoing painful medical procedures. Journal of consulting and clinical psychology, 1990, Volume: 58, Issue:6 Topics: Biopsy, Needle; Bone Marrow; Child; Child, Preschool; Cognitive Behavioral Therapy; Combined Modalit	1990
Relaxation response in femoral angiography. Radiology, 1990, Volume: 174, Issue:3 Pt 1 Topics: Angiography; Anxiety; Diazepam; Femoral Artery; Fentanyl; Humans; Music; Pain; Random Allocation; Re	1990
Influence of CGP 361A, propranolol and diazepam on autonomous reactions to different stressors. Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:1-2 Topics: Adrenergic beta-Antagonists; Adult; Anxiety; Autonomic Nervous System; Blood Pressure; Diazepam; Dou	1989
Diazepam mixed micelle--comparison with diazepam in propylene glycol and midazolam. Anaesthesia and intensive care, 1985, Volume: 13, Issue:4 Topics: Benzodiazepines; Blood Pressure; Diazepam; Female; Heart Rate; Humans; Micelles; Midazolam; Pain; Ph	1985
Neuroendocrine effects of diazepam in normal subjects following brief painful stress. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:5 Topics: Adult; beta-Endorphin; Diazepam; Humans; Hydrocortisone; Male; Pain; Stress, Physiological	1988
Failure of two benzodiazepines to prevent suxamethonium-induced muscle pain. Anaesthesia, 1985, Volume: 40, Issue:3 Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Diazepam; Double-Blind Method; Female; Humans; Male;	1985
Double-blind comparison of nalbuphine and meperidine in combination with diazepam for intravenous conscious sedation in oral surgery outpatients. Oral surgery, oral medicine, and oral pathology, 1988, Volume: 66, Issue:5 Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anxiety; Diazepam; Double-Blind Method; Female; Humans	1988
[Does diazepam prevent fasciculation and myalgias caused by suxamethonium? A double-blind study]. Ugeskrift for laeger, 1987, Feb-02, Volume: 149, Issue:6 Topics: Clinical Trials as Topic; Diazepam; Double-Blind Method; Fasciculation; Female; Gallamine Triethiodi	1987
A comparison of midazolam and diazepam for sedation during locoregional anesthesia. Acta anaesthesiologica Belgica, 1987, Volume: 38, Issue:1 Topics: Adult; Anesthesia, Local; Diazepam; Double-Blind Method; Female; Hemodynamics; Humans; Male; Midazol	1987
Reliability and validity of verbal descriptor scales of painfulness. Pain, 1987, Volume: 29, Issue:2 Topics: Adolescent; Adult; Diazepam; Electric Stimulation; Female; Fentanyl; Humans; Male; Pain; Pain Measur	1987
Naloxone, fentanyl, and diazepam modify plasma beta-endorphin levels during surgery. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2 Topics: Diazepam; Double-Blind Method; Drug Evaluation; Endorphins; Fentanyl; Humans; Intraoperative Period;	1986
Lidocaine reduces intravenous diazepam pain. The Journal of emergency medicine, 1985, Volume: 3, Issue:5 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; In	1985
Diazepam reduces stress-induced analgesia in humans. Brain research, 1986, Jan-08, Volume: 362, Issue:2 Topics: Adult; Analgesia; Diazepam; Differential Threshold; Dose-Response Relationship, Drug; Double-Blind M	1986
Use of methylprednisolone acetate in vasectomy. Urology, 1974, Volume: 4, Issue:6 Topics: Clinical Trials as Topic; Codeine; Diazepam; Disability Evaluation; Follow-Up Studies; Humans; Male;	1974
Alterations in response to somatic pain associated with anaesthesia. XIX: Studies with the drugs used in neuroleptanaesthesia. British journal of anaesthesia, 1970, Volume: 42, Issue:10 Topics: Affect; Benperidol; Clinical Trials as Topic; Diazepam; Drug Synergism; Female; Fentanyl; Heroin; Hu	1970
[Doxepin--a new anxiolytic antidepressant]. Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1970, Volume: 24, Issue:2 Topics: Antidepressive Agents; Anxiety; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Depression;	1970
[An experimental study on the premedication effect of promethazine and diazepam]. Suomen Hammaslaakariseuran toimituksia = Finska tandlakarsallskapets forhandlingar, 1971, Volume: 67, Issue:5 Topics: Adult; Dental Pulp Test; Diazepam; Female; Humans; Male; Pain; Placebos; Premedication; Promethazine	1971
[Experiences with faustan for the prevention of muscle pain from succinyl choline administration]. Zentralblatt fur Chirurgie, 1970, Aug-08, Volume: 95, Issue:32 Topics: Atropine; Diazepam; Female; Humans; Male; Meperidine; Muscles; Pain; Succinylcholine	1970
[The reaction of the skin vessels in pain irritation and its pharmacologic susceptibility]. Zeitschrift fur Kreislaufforschung, 1966, Volume: 55, Issue:10 Topics: Adult; Aminopyrine; Diazepam; Emotions; Female; Hemodynamics; Humans; Male; Middle Aged; Pain; Respi	1966

Article	Year
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal;	2008
Antinociceptive properties of bergenin. Journal of natural products, 2011, Oct-28, Volume: 74, Issue:10 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Dose-Response Relationshi	2011
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief. Bioorganic & medicinal chemistry, 2011, Dec-15, Volume: 19, Issue:24 Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan	2011
Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4 Topics: Agave; Analgesics; Animals; Glyburide; KATP Channels; Male; Mice; Molecular Structure; Naltrexone; P	2013
Syntheses, characterization and evaluation of novel 2,6-diarylpiperidin-4-ones as potential analgesic-antipyretic agents. European journal of medicinal chemistry, 2014, Jul-23, Volume: 82 Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Dose-Response Relationship, Drug;	2014
Antinociceptive properties of physalins from Physalis angulata. Journal of natural products, 2014, Nov-26, Volume: 77, Issue:11 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp	2014
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. Pain, 2022, 07-01, Volume: 163, Issue:7 Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammator	2022
Effects of oxycodone and diazepam alone and in combination on operant nociception. Behavioural pharmacology, 2020, Volume: 31, Issue:2&3 Topics: Analgesics; Animals; Conditioning, Operant; Diazepam; Drug Therapy, Combination; Male; Models, Anima	2020
Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls. The Journal of pharmacology and experimental therapeutics, 2021, Volume: 377, Issue:2 Topics: Amphetamine; Analgesics; Animals; Behavior, Animal; Diazepam; Drug Evaluation, Preclinical; False Ne	2021
Nursing a critically ill tetanus patient in an intensive care unit in Zambia. British journal of nursing (Mark Allen Publishing), 2017, May-11, Volume: 26, Issue:9 Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic	2017
Increasing efficacy and reducing side effects in treatment of chronic anal fissures: A study of topical diazepam therapy. Medicine, 2017, Volume: 96, Issue:20 Topics: Administration, Topical; Analgesics; Chronic Disease; Diazepam; Dose-Response Relationship, Drug; Dr	2017
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam. Behavioural pharmacology, 2019, Volume: 30, Issue:5 Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Electric Stimulation; Ketoro	2019
Successful treatment of refractory dermal pain with etizolam and clonazepam in a patient with acquired idiopathic generalized anhidrosis. The Journal of dermatology, 2019, Volume: 46, Issue:10 Topics: Adult; Biopsy; Clonazepam; Diazepam; Drug Resistance; Drug Therapy, Combination; Gabapentin; Glucoco	2019
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nature communications, 2015, Apr-13, Volume: 6 Topics: Analgesia; Animals; Arginine; Benzodiazepines; Diazepam; GABA Modulators; Gene Expression; Histidine	2015
[Experimental comparative study of the analgesic activity of the diurnal anxiolytic mebicar, amitriptyline, and diazepam]. Eksperimental'naia i klinicheskaia farmakologiia, 2015, Volume: 78, Issue:3 Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Biureas; Diazepam; Female; Ma	2015
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits. Behavioural brain research, 2016, Mar-15, Volume: 301 Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D	2016
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. Pain medicine (Malden, Mass.), 2009, Volume: 10, Issue:3 Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin;	2009
Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. Brain research, 2010, Aug-19, Volume: 1349 Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Area Under Curve; Behavior, Animal; Diazepam; Disea	2010
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach. Journal of biomedicine & biotechnology, 2010, Volume: 2010 Topics: Acetic Acid; Action Potentials; Analgesics; Animals; Behavior, Animal; Biological Assay; Diazepam; E	2010
A case of thalamic pain successfully treated with Kampo medicine. Journal of alternative and complementary medicine (New York, N.Y.), 2011, Volume: 17, Issue:6 Topics: Aged; Analgesics; Diazepam; Female; Humans; Infarction; Medicine, Kampo; Movement Disorders; Nausea;	2011
Safety of subcutaneous microinjections (mesotherapy) in musicians. Medical problems of performing artists, 2011, Volume: 26, Issue:2 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diazepam; Female; Humans; In	2011
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. Behavioural brain research, 2012, Apr-01, Volume: 229, Issue:1 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dark Adaptation; Diaze	2012
Assessment of pain in sedated and mechanically ventilated patients: an observational study. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Analysis of Variance; Behavior; Cons	2012
The effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test: anxiolysis vs. pain modulation. Neuropharmacology, 2012, Volume: 63, Issue:2 Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Male; Motor Activity;	2012
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats. Neuropharmacology, 2012, Volume: 63, Issue:8 Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxy	2012
ROLE OF RELAXANTS IN TREATMENT OF TRAUMATIC MUSCULOSKELETAL DISORDERS: A DOUBLE-BLIND STUDY OF THREE AGENTS. Current therapeutic research, clinical and experimental, 1964, Volume: 6 Topics: Anxiety; Anxiety Disorders; Biomedical Research; Carisoprodol; Chlormezanone; Diazepam; Double-Blind	1964
EVALUATION OF DIAZEPAM (VALIUM) IN THE SYMPTOMATIC TREATMENT OF RHEUMATIC DISORDERS. A CONTROLLED COMPARATIVE STUDY. Journal of chronic diseases, 1965, Volume: 18 Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Carisoprodol; Chlormezanone; Diazepa	1965
PAINFUL MUSCULAR CONDITIONS TREATED WITH DIAZEPAM. The Practitioner, 1965, Volume: 194 Topics: Biomedical Research; Diazepam; Humans; Pain	1965
THE LEVATOR SYNDROME AND ITS TREATMENT. Southern medical journal, 1965, Volume: 58 Topics: Anus Diseases; Diazepam; Drug Therapy; Humans; Pain; Sacrococcygeal Region; Spasm	1965
[ON THE DIAGNOSIS AND THERAPY OF MYOGENIC PAIN IN DEGENERATIVE CHANGES OF THE SPINE IN GERIATRICS]. Wiener klinische Wochenschrift, 1964, Nov-27, Volume: 76 Topics: Diazepam; Geriatrics; Humans; Muscle Cramp; Pain; Spinal Diseases	1964
Pharmacological characterisation of acid-induced muscle allodynia in rats. European journal of pharmacology, 2004, Mar-08, Volume: 487, Issue:1-3 Topics: Acids; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Carbazoles; Chr	2004
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. Psychopharmacology, 2005, Volume: 180, Issue:3 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D	2005
A new assay of thermal-based avoidance test in freely moving mice. The journal of pain, 2005, Volume: 6, Issue:7 Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Biological A	2005
Modifications in avoidance reactions of mice, on a second exposure to the hot plate, resist to various amnesia-inducing treatments. Brain research. Cognitive brain research, 2005, Volume: 25, Issue:1 Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Dementia; Diaz	2005
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:4 Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides;	2006
Changes in anxiety levels are followed by changes in behavioral strategy in mice subjected to stress and in the extent of stress-induced analgesia. Neuroscience and behavioral physiology, 2006, Volume: 36, Issue:2 Topics: Adaptation, Physiological; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Convu	2006
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism. Phytotherapy research : PTR, 2006, Volume: 20, Issue:7 Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Ago	2006
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2006, Volume: 13, Issue:8 Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba	2006
Influence of pharmacologically-induced experimental anxiety on nociception and antinociception in rats. European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Diazepam; Do	2006
Adequacy of pain relief in closed manipulative reduction of fracture and dislocation. The Medical journal of Malaysia, 2006, Volume: 61 Suppl A Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Analgesia; Child; Cross-Sectional Studies; Diazepam;	2006
The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. Magnetic resonance imaging, 2007, Volume: 25, Issue:6 Topics: Anti-Anxiety Agents; Behavior; Brain; Brain Mapping; Cohort Studies; Color; Diazepam; Humans; Light;	2007
Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature, 2008, Jan-17, Volume: 451, Issue:7176 Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz	2008
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. Behavioural brain research, 2008, May-16, Volume: 189, Issue:1 Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper	2008
[On the significance of affects for the behavior of the peripheral blood vessels and their modification by pharmaceuticals]. Arzneimittel-Forschung, 1966, Volume: 16, Issue:5 Topics: Adult; Aminopyrine; Diazepam; Female; Humans; Male; Middle Aged; Pain; Skin; Triflupromazine; Vascul	1966
When drugs can help in multiple sclerosis. Drugs, 1980, Volume: 19, Issue:6 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Baclofen; Dantrolene; Diazepam; Humans; Immuno	1980
Analgesia induced by painful stimulation and/or anticipation of pain; different mechanisms are operating. Physiologia Bohemoslovaca, 1984, Volume: 33, Issue:2 Topics: Analgesia; Animals; Chlorpromazine; Dexamethasone; Diazepam; Electric Stimulation; Humans; Naloxone;	1984
[Effect of benzodiazepines on neuropathologic syndromes of spinal origin]. Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 97, Issue:1 Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Myoclonus; P	1984
Pain-induced vocalization in the rat and its modification by pharmacological agents. Brain research, 1984, Mar-26, Volume: 296, Issue:1 Topics: Animals; Diazepam; Electric Stimulation; Emotions; Heart Rate; Male; Morphine; Pain; Rats; Rats, Inb	1984
Long-term use of diazepam. JAMA, 1981, Oct-02, Volume: 246, Issue:14 Topics: Adult; Aged; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Muscle Cramp; Nordazepam; Pain;	1981
Painful intravenous injections of diazepam. Anaesthesia, 1983, Volume: 38, Issue:2 Topics: Diazepam; Humans; Pain; Propylene Glycol; Propylene Glycols	1983
Diazepam-induced suppression of jaw opening reflex in rats. The Bulletin of Tokyo Medical and Dental University, 1980, Volume: 27, Issue:1 Topics: Analgesics; Animals; Dental Pulp; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation;	1980
Aspirin in the prevention of painful intravenous injection of disoprofol (ICI35,868) and diazepam (Valium). Anaesthesia, 1982, Volume: 37, Issue:8 Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics; Aspirin; Diazepam; Female; Fentanyl; Humans	1982
Diazepam-induced release of opioid activity in the rat brain. Neuroscience letters, 1980, Volume: 16, Issue:3 Topics: Analgesics; Animals; Bacitracin; Brain; Diazepam; Enkephalins; Male; Pain; Rats; Rats, Inbred Strain	1980
[Tasks and problems of general medical care in certain groups of disorders. Patients with mixed (motor and sensory) paralyses--from a neurological viewpoint]. Zeitschrift fur arztliche Fortbildung, 1982, Jun-01, Volume: 76, Issue:11 Topics: Baclofen; Demyelinating Diseases; Diazepam; Electrogalvanism, Intraoral; Exercise Therapy; Hemiplegi	1982
Diazepam in an oil emulsion. Anesthesia and analgesia, 1982, Volume: 61, Issue:6 Topics: Adult; Aged; Diazepam; Double-Blind Method; Emulsions; Humans; Injections, Intravenous; Middle Aged;	1982
Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs. Anesthesia and analgesia, 1982, Volume: 61, Issue:9 Topics: Adolescent; Adult; Dental Pulp; Diazepam; Double-Blind Method; Drug Evaluation; Electric Stimulation	1982
Reversibility of diazepam overdose by physostigmine. Proceedings of the Western Pharmacology Society, 1981, Volume: 24 Topics: Acoustic Stimulation; Animals; Cats; Diazepam; Female; Male; Pain; Physostigmine	1981
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications. Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1 Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions;	1980
Chlordiazepoxide and GABA injected into raphé dorsalis release the conditioned behavioural suppression induced in rats by a conflict procedure without nociceptive component. Neuropharmacology, 1980, Volume: 19, Issue:7 Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Diazepam; gamma-Aminobuty	1980
Prevention of pain and phlebitis due to diazepam injection. Anaesthesia, 1980, Volume: 35, Issue:4 Topics: Diazepam; Humans; Injections, Intravenous; Pain; Phlebitis	1980
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice. Japanese journal of pharmacology, 1995, Volume: 68, Issue:2 Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehy	1995
Altered responses to medications exposed to excessive temperatures during shipping. Southern medical journal, 1995, Volume: 88, Issue:6 Topics: Chronic Disease; Diazepam; Drug Stability; Drug Storage; Female; Hot Temperature; Humans; Meperidine	1995
Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems. Pain, 1994, Volume: 56, Issue:3 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cholecystokinin; Chronic Disease; Diazepam; Endorphi	1994
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. Japanese journal of pharmacology, 1994, Volume: 65, Issue:4 Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm	1994
Stress-induced hypoalgesia and defensive freezing are attenuated by application of diazepam to the amygdala. Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:2 Topics: Amygdala; Analysis of Variance; Animals; Diazepam; Fear; Female; Motor Activity; Pain; Rats; Stress,	1993
High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:3 Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Conflict, Psychological; Diazepam; Ind	1997
Comparison of pain, motility, and preoperative sedation in cataract phacoemulsification patients receiving peribulbar or sub-Tenon's anesthesia. Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:6 Topics: Anesthesia, Local; Anesthetics, Local; Diazepam; Eye Movements; Follow-Up Studies; Humans; Hypnotics	1998
Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient. Annals of the New York Academy of Sciences, 1999, Jun-29, Volume: 877 Topics: Amygdala; Animals; Anti-Anxiety Agents; beta-Galactosidase; Diazepam; Enkephalins; Gene Expression R	1999
[Pediatricians' opinion on sedation in children]. Anales espanoles de pediatria, 1999, Volume: 51, Issue:3 Topics: Adult; Age Factors; Aged; Anesthesia; Anti-Anxiety Agents; Attitude of Health Personnel; Child; Chlo	1999
Antinociceptive effects of the tubercles of Anredera leptostachys. Journal of ethnopharmacology, 1999, Dec-15, Volume: 68, Issue:1-3 Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Caribbean Region; Diazepam; Dose-Response Relati	1999
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. Proceedings of the National Academy of Sciences of the United States of America, 2000, Apr-25, Volume: 97, Issue:9 Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological;	2000
Seizures with intravenous codeine phosphate. The Annals of pharmacotherapy, 2001, Volume: 35, Issue:10 Topics: Analgesics, Opioid; Anemia, Sickle Cell; Anticonvulsants; Child; Codeine; Diazepam; Humans; Injectio	2001
Diazepam effects on the cerebral responses to tonic pain: a SPET study. Psychopharmacology, 2001, Volume: 158, Issue:3 Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Brain; Cold Temperature; Diazepam; Humans; Male; P	2001
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice. Life sciences, 2002, Mar-01, Volume: 70, Issue:15 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics	2002
Letter: Injecting the painful shoulder. Lancet (London, England), 1976, Feb-07, Volume: 1, Issue:7954 Topics: Cyclizine; Diazepam; Drug Therapy, Combination; Humans; Injections, Intra-Articular; Injections, Int	1976
Drug-induced encephalopathy in patients on maintenance haemodialysis. Lancet (London, England), 1976, Oct-02, Volume: 2, Issue:7988 Topics: Aged; Anti-Anxiety Agents; Arthritis; Coronary Disease; Dementia; Diazepam; Flurazepam; Fractures, B	1976
[Investigations on pain reduction during peripheral angiography (author's transl)]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1979, Volume: 130, Issue:2 Topics: Angiography; Diazepam; Extremities; Female; Femoral Artery; Humans; Injections, Intravenous; Male; M	1979
[Antistress effects of diazepam and activation of the positive reinforcing system upon changes on corticosteroid excretion and lipid level after peripheral electric pain stimulation]. Biulleten' eksperimental'noi biologii i meditsiny, 1979, Volume: 88, Issue:9 Topics: 11-Hydroxycorticosteroids; Animals; Diazepam; Electric Stimulation; Lipoproteins; Lipoproteins, LDL;	1979
Conscious sedation with intravenous drugs: a study of amnesia. Journal of oral surgery (American Dental Association : 1965), 1978, Volume: 36, Issue:3 Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Anxiety; Diazepam; Drug Combinations; F	1978
The effects of diazepam, morphine and lidocaine on nociception in rhesus monkeys: a signal detection analysis. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:2 Topics: Animals; Diazepam; Discrimination, Psychological; Electric Stimulation; Escape Reaction; Haplorhini;	1978
Drug abuse and dependency in patients with chronic pain. Mayo Clinic proceedings, 1979, Volume: 54, Issue:4 Topics: Age Factors; Chronic Disease; Codeine; Dextropropoxyphene; Diazepam; Female; Humans; Intelligence; M	1979
[Use of phentanyl with droperidol or seduxen in nitrous oxide anesthesia in patients with blood vessel diseases of the lower extremities accompanied by pain syndrome]. Klinicheskaia khirurgiia, 1979, Issue:2 Topics: Adult; Anesthesia, Inhalation; Diazepam; Droperidol; Fentanyl; Humans; Middle Aged; Nitrous Oxide; P	1979
[Characteristics of combined nitrous oxide nacrosis and premedication with phentanyl and droperidol or phentanyl and seduxen in patients with pain syndrome caused by blood vessel diseases of the lower extremities]. Vestnik khirurgii imeni I. I. Grekova, 1979, Volume: 122, Issue:2 Topics: Adult; Aged; Anesthesia, Endotracheal; Diazepam; Droperidol; Drug Therapy, Combination; Fentanyl; Hu	1979
Pain of first-trimester abortion: its quantification and relations with other variables. American journal of obstetrics and gynecology, 1979, Mar-01, Volume: 133, Issue:5 Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai	1979
Pain of first-trimester abortion: its quantification and relations with other variables. American journal of obstetrics and gynecology, 1979, Mar-01, Volume: 133, Issue:5 Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai	1979
Pain of first-trimester abortion: its quantification and relations with other variables. American journal of obstetrics and gynecology, 1979, Mar-01, Volume: 133, Issue:5 Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai	1979
Pain of first-trimester abortion: its quantification and relations with other variables. American journal of obstetrics and gynecology, 1979, Mar-01, Volume: 133, Issue:5 Topics: Abortion, Induced; Anesthesia, Local; Diazepam; Evaluation Studies as Topic; Female; Humans; Lidocai	1979
Analgesic action and pharmacokinetics of morphine and diazepam in man: an evaluation by sensory decision theory. Anesthesiology, 1979, Volume: 51, Issue:6 Topics: Analgesics; Diazepam; Humans; Kinetics; Male; Morphine; Pain; Placebos; Sodium Chloride	1979
A clinical study of local reactions following intravenous diazepam. The Journal of the Association of Physicians of India, 1979, Volume: 27, Issue:7 Topics: Diazepam; Female; Humans; Injections, Intravenous; Male; Pain; Thrombophlebitis	1979
[Differential diagnostic criteria in cervico-brachial psychalgia]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1979, Nov-15, Volume: 34, Issue:22 Topics: Brachial Plexus Neuritis; Conflict, Psychological; Diagnosis, Differential; Diazepam; Galvanic Skin	1979
[Preliminary clinical observations on the use of the narcotic, Etomidate, in anesthesiology. Evaluation of the MPC dose and equivalent dose]. Minerva anestesiologica, 1979, Volume: 45, Issue:3 Topics: Adolescent; Adult; Anesthesia; Diazepam; Dose-Response Relationship, Drug; Etomidate; Humans; Imidaz	1979
Psychopharmacology for psychiatric and psychiatric-organic diseases. Comprehensive therapy, 1978, Volume: 4, Issue:5 Topics: Antidepressive Agents, Tricyclic; Anxiety; Depression; Diazepam; Dose-Response Relationship, Drug; D	1978
Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: manipulation of affect by diazepam. Pain, 1978, Volume: 5, Issue:1 Topics: Adolescent; Adult; Affect; Diazepam; Electric Stimulation; Female; Humans; Male; Pain; Sensation; Ti	1978
Effect of pain on human psychomotor performance. Acta anaesthesiologica Scandinavica, 1978, Volume: 22, Issue:3 Topics: Adult; Diazepam; Flicker Fusion; Humans; Male; Motor Activity; Motor Skills; Pain; Time Factors; Vit	1978
Uptake of 3H-leucine into the brain and other organs during the conditioned reaction to painful stimulation; effect of diazepam. Activitas nervosa superior, 1976, Volume: 18, Issue:1-2 Topics: Animals; Brain; Conditioning, Classical; Diazepam; Humans; Leucine; Male; Nerve Tissue Proteins; Org	1976
Chronic MPD, group therapy and psychodynamics. Journal of the American Dental Association (1939), 1975, Volume: 90, Issue:4 Topics: Attitude; Diazepam; Ethanol; Facial Muscles; Humans; Interpersonal Relations; Meprobamate; MMPI; Mus	1975
Myofascial pain dysfunction syndrome involving tumor metastasis. Case report. Journal of periodontology, 1975, Volume: 46, Issue:5 Topics: Breast Neoplasms; Diagnosis, Differential; Diazepam; Facial Muscles; Female; Humans; Mandibular Neop	1975
Chronic myofascial pain-dysfunction syndrome with chest pain. The Journal of prosthetic dentistry, 1975, Volume: 34, Issue:4 Topics: Adult; Diazepam; Facial Muscles; Female; Humans; Malocclusion; Masticatory Muscles; Muscular Disease	1975
Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery. Journal of oral surgery (American Dental Association : 1965), 1976, Volume: 34, Issue:4 Topics: Adolescent; Adult; Anxiety; Cannabis; Diazepam; Dronabinol; Emotions; Hippocampus; Humans; Injection	1976
Physiological responses under dental sedation and anaesthesia. Dental anaesthesia and sedation, 1976, Volume: 5, Issue:3 Topics: Analgesia; Anesthesia, Dental; Anxiety; Atropine; Blood Pressure; Diazepam; Epinephrine; Heart Rate;	1976
[Effect of diazepam on coronary circulation and myocardial metabolism in subjects with normal coronary arteries and patients with coronary arteriosclerosis]. L'union medicale du Canada, 1975, Volume: 104, Issue:1 Topics: Adult; Arteriosclerosis; Coronary Circulation; Coronary Disease; Diazepam; Female; Hemodynamics; Hum	1975
Letter: some pitfalls in the psychophysical assessment of drug effects: another look at the effects of diazepam on pain threshold. British journal of anaesthesia, 1975, Volume: 47, Issue:5 Topics: Diazepam; Drug Evaluation; Humans; Pain; Psychology	1975
Adverse effects of lumbar myelography with amipaque and dimer-X. Acta radiologica: diagnosis, 1976, Volume: 17, Issue:2 Topics: Adult; Aged; Brain; Diazepam; Drug Evaluation; Electroencephalography; Female; Fever; Headache; Huma	1976
[The effects of pentazocine, diazepam and midazolam in patients to reduce the uncomfortable feeling during epidural block procedure]. Masui. The Japanese journal of anesthesiology, 1992, Volume: 41, Issue:11 Topics: Adult; Anesthesia, Epidural; Anxiety; Diazepam; Female; Humans; Male; Midazolam; Pain; Pentazocine;	1992
Effects of diazepam and chlorpromazine on socially induced anxiety in pigeons. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1991, Volume: 1, Issue:4 Topics: Animals; Anxiety; Chlorpromazine; Columbidae; Conditioning, Operant; Diazepam; Dose-Response Relatio	1991
Premedication and short term complications in iohexol discography. Annales chirurgiae et gynaecologiae, 1991, Volume: 80, Issue:1 Topics: Adult; Back Pain; Diazepam; Female; Glycopyrrolate; Headache; Humans; Injections, Spinal; Interverte	1991
[The legal importance of immediate pain in injection errors]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1991, Volume: 62, Issue:6 Topics: Diazepam; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Ma	1991
[Premedication and analgesic dose procedures in dental medicine]. Zahnarztliche Praxis, 1991, Jul-12, Volume: 42, Issue:7 Topics: Anesthesia, Dental; Anesthesia, Local; Buprenorphine; Clorazepate Dipotassium; Diazepam; Flunitrazep	1991
Morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats. Anesthesia and analgesia, 1990, Volume: 71, Issue:3 Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Male; Morphine; Mo	1990
Effect of diazepam on behaviour and associated changes in ascorbate concentration in rat brain areas: striatum, n. accumbens and hippocampus. Psychopharmacology, 1990, Volume: 100, Issue:2 Topics: Animals; Ascorbic Acid; Behavior, Animal; Brain Chemistry; Corpus Striatum; Diazepam; Electrodes, Im	1990
Diazepam attenuates morphine antinociception test-dependently in mice. Pharmacology & toxicology, 1990, Volume: 66, Issue:5 Topics: Analgesics; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Mal	1990
[Control of pain and anxiety in pedodontics]. Revista de actualidad estomatologica espanola, 1989, Volume: 49, Issue:386 Topics: Anesthesia, Dental; Anxiety; Child; Child, Preschool; Diazepam; Humans; Hydroxyzine; Ketamine; Nitro	1989
Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline. Pain, 1989, Volume: 37, Issue:2 Topics: Amitriptyline; Animals; Behavior, Animal; Denervation; Diazepam; Hindlimb; Male; Pain; Peripheral Ne	1989
Noradrenergic mechanisms in mediation of stress-induced hyperalgesia in rats. Pain, 1988, Volume: 32, Issue:3 Topics: Analgesia; Animals; Clonidine; Diazepam; Norepinephrine; Pain; Rats; Receptors, Adrenergic, alpha; S	1988
Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788. Japanese journal of pharmacology, 1985, Volume: 37, Issue:1 Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Cholecystokinin; Diaz	1985
[Analysis of the influence of anxiolytics on the pain reactions of rats compared to the effect of morphine]. Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:5 Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation	1987
The possible role of benzodiazepine receptors in morphine analgesia. Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:1 Topics: Animals; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Male; Mice; Morphine; Pain; Rec	1986
Neurobehavioral, neuroendocrine and neurochemical effects of zinc supplementation in rats. Advances in experimental medicine and biology, 1986, Volume: 203 Topics: Adrenocorticotropic Hormone; Animals; Baclofen; Behavior, Animal; beta-Endorphin; Brain; Diazepam; E	1986
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 333, Issue:1 Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricula	1986
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component. Brain research bulletin, 1987, Volume: 19, Issue:1 Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil;	1987
Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice. Physiology & behavior, 1988, Volume: 43, Issue:2 Topics: Analgesia; Animals; Appetitive Behavior; Diazepam; Flumazenil; Handling, Psychological; Hot Temperat	1988
[Potentiation concept in pharmacology]. Minerva anestesiologica, 1988, Volume: 54, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combin	1988
[Prevention of myalgia after intravenous administration of succinylcholine iodide]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1988, Volume: 67, Issue:2 Topics: Anesthesia, General; Diazepam; Fasciculation; Humans; Injections, Intravenous; Muscles; Pain; Succin	1988
Conditional analgesia, defensive freezing, and benzodiazepines. Behavioral neuroscience, 1988, Volume: 102, Issue:2 Topics: Animals; Benzodiazepines; Conditioning, Classical; Cytidine Diphosphate; Defense Mechanisms; Diazepa	1988
One stressful event blocks multiple actions of diazepam for up to at least a month. Brain research, 1988, Apr-05, Volume: 445, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebral Cortex; Diazepam; Dopamine; Male; Pain; Pentylenet	1988
The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. Laboratory animal science, 1987, Volume: 37, Issue:6 Topics: Anesthesia; Anesthetics; Animals; Diazepam; Droperidol; Drug Combinations; Fentanyl; Ketamine; Male;	1987
Somatovegetative changes in stress-induced analgesia in man: an electrophysiological and pharmacological study. Annals of the New York Academy of Sciences, 1986, Volume: 467 Topics: Adult; Analgesia; Diazepam; Double-Blind Method; Electrophysiology; Female; H-Reflex; Heart Rate; Hu	1986
Influence of diazepam on the effects of suxamethonium. Journal of the Indian Medical Association, 1986, Volume: 84, Issue:9 Topics: Adolescent; Adult; Anesthesia, Intravenous; Diazepam; Fasciculation; Female; Humans; Male; Middle Ag	1986
[Does diazepam prevent against suxamethonium-induced fasciculation and myalgia?]. Ugeskrift for laeger, 1987, Mar-02, Volume: 149, Issue:10 Topics: Diazepam; Fasciculation; Humans; Muscular Diseases; Pain; Succinylcholine	1987
Intrathecal diazepam suppresses nociceptive reflexes and potentiates electroacupuncture effects in pentobarbital-anesthetized rats. Neuroscience letters, 1987, Jun-26, Volume: 77, Issue:3 Topics: Acupuncture Therapy; Anesthesia, Intravenous; Animals; Diazepam; Drug Synergism; Humans; Injections,	1987
[Effects of lidocaine, meperidine or fentanyl on pain and clinical thrombophlebitis induced by intravenous diazepam]. Ma zui xue za zhi = Anaesthesiologica Sinica, 1987, Volume: 25, Issue:3 Topics: Adult; Diazepam; Female; Fentanyl; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Lido	1987
Assessment and management of chronic pain. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, May-10, Volume: 69, Issue:10 Topics: Analgesics; Anticonvulsants; Antidepressive Agents; Chronic Disease; Diazepam; Hospital Units; Human	1986
Sedation and pain management during pacemaker implantation, electrophysiologic testing, and related procedures. Clinical therapeutics, 1985, Volume: 8, Issue:1 Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Local; Diazepam; Electrophysiology; Female; Humans;	1985
Differential diagnosis of weakness--a common geriatric symptom. Geriatrics, 1986, Volume: 41, Issue:4 Topics: Aged; Alcoholism; Arthritis; Cardiovascular Diseases; Depression; Diabetes Complications; Diagnosis,	1986
Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:2 Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Pain; Rats; React	1986
Iatrogenic and functional leg pain. Geriatrics, 1973, Volume: 28, Issue:9 Topics: Aged; Analgesics; Aspirin; Diagnosis, Differential; Diazepam; Fear; Fibromyalgia; Humans; Iatrogenic	1973
Editorial: Anguish unremembered? Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864 Topics: Amnesia; Anesthesia; Anesthesia, Dental; Autonomic Nervous System; Consciousness; Diazepam; Humans;	1974
[Analgesia in myocardial infarct]. Zeitschrift fur Kardiologie, 1974, Volume: 63, Issue:12 Topics: Analgesics; Diazepam; Heart; Hemodynamics; Heroin; Humans; Hydromorphone; Meperidine; Methadone; Mor	1974
Anesthesia for diagnostic and operative laparoscopy. Fertility and sterility, 1971, Volume: 22, Issue:10 Topics: Abdomen; Adolescent; Adult; Analgesia; Anesthesia; Anesthesia, General; Anesthesia, Local; Diazepam;	1971
[Syndromes of permanent contracture (stiff-man syndrome of Moersch and Woltman; Isaacs' syndrome of continual activity of the muscle fibers, other permanent contractures). Attempted classification and pathogenic interpretation. Discussion of the role of t Revue neurologique, 1971, Volume: 124, Issue:3 Topics: Carbamazepine; Contracture; Diazepam; Electromyography; Fibromyalgia; Hydantoins; Interneurons; Moto	1971
Laparoscopic tubal clip sterilization under local anesthesia. Fertility and sterility, 1974, Volume: 25, Issue:9 Topics: Adult; Anesthesia, Local; Diazepam; Drug Evaluation; Fallopian Tubes; Female; Fentanyl; Humans; Lapa	1974
The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydrohomopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. II. Toxicity and analgetic effect of MZ-144 compared to narcotic and non-narcotic analgesics. Arzneimittel-Forschung, 1971, Volume: 21, Issue:5 Topics: Aminopyrine; Amobarbital; Analgesics; Animals; Aspirin; Blood; Cats; Codeine; Diazepam; Dogs; Drug A	1971
[Neuroleptics, thymoleptics and tranquilizers in neurological therapy]. Bibliotheca psychiatrica et neurologica, 1969, Volume: 139 Topics: Basal Ganglia Diseases; Chlordiazepoxide; Chlorpromazine; Diazepam; Epilepsy; Extrapyramidal Tracts;	1969
Head and neck pain: T-M joint syndrome. The Laryngoscope, 1974, Volume: 84, Issue:9 Topics: Adult; Age Factors; Aged; Diagnosis, Differential; Diazepam; Female; Head; Humans; Lidocaine; Male;	1974
[Treatment of acute emotional disturbances]. Deutsche medizinische Wochenschrift (1946), 1974, Oct-18, Volume: 99, Issue:42 Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char	1974
Diazepam compared to thiopentone as induction agent for caesarean sections. Acta anaesthesiologica Scandinavica, 1974, Volume: 18, Issue:4 Topics: Amnesia; Anesthesia, Intravenous; Anesthesia, Obstetrical; Apgar Score; Atropine; Cesarean Section;	1974
Use of sedation-analgesia in general dentistry. Journal of the Canadian Dental Association, 1973, Volume: 39, Issue:7 Topics: Analgesia; Anesthesia, Dental; Diazepam; Humans; Meperidine; Nitrous Oxide; Pain; Pentobarbital; Sco	1973
Sleep studies and therepeutic trial with L-dopa in a case of Stiffman syndrome. European neurology, 1973, Volume: 10, Issue:2 Topics: Benzodiazepinones; Chlorobenzenes; Diazepam; Dihydroxyphenylalanine; Electrocardiography; Electromyo	1973
[Analgesia and stress relief in oral surgery with local anesthesia]. Deutsche zahnarztliche Zeitschrift, 1973, Volume: 28, Issue:10 Topics: Anesthesia, Local; Diazepam; Humans; Injections, Intravenous; Pain; Pentazocine; Preanesthetic Medic	1973
Control of the anxiety-pain complex in dentistry. Intravenous psychosedation with techniques using diazepam. Oral surgery, oral medicine, and oral pathology, 1974, Volume: 37, Issue:3 Topics: Anesthesia, Intravenous; Anxiety; Atropine; Blood Pressure; Dental Care; Diazepam; Evaluation Studie	1974
Facial pain as a presentation in Von Munchausen's syndrome: a case report. The British journal of oral surgery, 1974, Volume: 12, Issue:1 Topics: Adult; Diazepam; Electroencephalography; Face; Humans; Male; Munchausen Syndrome; Neurologic Examina	1974
[Influences of some tranquillizers on analgesic effect of aminopyrine (author's transl)]. Shika gakuho. Dental science reports, 1974, Volume: 74, Issue:7 Topics: Aminopyrine; Animals; Diazepam; Drug Combinations; Hydroxyzine; Mice; Pain	1974
[Serum creatine phosphokinase and intramuscular injections]. Schweizerische medizinische Wochenschrift, 1973, Jun-30, Volume: 103, Issue:26 Topics: Adult; Creatine Kinase; Diazepam; Female; Humans; Hydroxybutyrate Dehydrogenase; Injections, Intramu	1973
Epileptic pain. An uncommon manifestation with localizing value. Neurology, 1973, Volume: 23, Issue:5 Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma	1973
[Valium in the daily surgical and orthopedic practice]. Zeitschrift fur Unfallmedizin und Berufskrankheiten. Revue de medecine des accidents et des maladies professionelles, 1973, Volume: 66, Issue:3 Topics: Aged; Diazepam; Female; Humans; Male; Middle Aged; Minor Surgical Procedures; Orthopedics; Pain	1973
Patient's views on general anaesthesia. Annales chirurgiae et gynaecologiae Fenniae, 1973, Volume: 62, Issue:5 Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Attitude; Cognition; Diazepam;	1973
Spinal fracture following radiculography using meglumine iothalamate (Conray). Neuroradiology, 1973, Volume: 6, Issue:2 Topics: Adipates; Adult; Contrast Media; Diazepam; Female; Fractures, Bone; Humans; Hypesthesia; Iothalamic	1973
[A further case of tetanus-like contracture distinct from the stiff man syndrome. Pharmacological and neuropathological study of a case of predominantly spinal encephalomyelitis]. Revue neurologique, 1973, Volume: 128, Issue:1 Topics: Aged; Carbamazepine; Contracture; Diazepam; Dihydroxyphenylalanine; Electromyography; Encephalomyeli	1973
[The effect tranquilizers and antidepressants on the summation of impulses of different modalities]. Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:4 Topics: Animals; Auditory Perception; Central Nervous System; Chlordiazepoxide; Conditioning, Classical; Dep	1973
Effect of diazepam on experimentally induced pain thresholds. British journal of anaesthesia, 1974, Volume: 46, Issue:1 Topics: Anesthesia, Local; Diazepam; Epinephrine; Hot Temperature; Humans; Leg; Pain; Pressure; Skin Tests;	1974
Letter: Cremophor EL as a diluent for diazepam. British medical journal, 1974, Jul-27, Volume: 3, Issue:5925 Topics: Diazepam; Humans; Injections, Intravenous; Pain; Pharmaceutic Aids; Solubility	1974
[Painless delivery with paracervical block and changes in the concentration of the local anesthetic in the blood]. Nihon Sanka Fujinka Gakkai zasshi, 1971, Volume: 23, Issue:5 Topics: Adolescent; Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood P	1971
Drugs in the management of myocardial infarction. Journal of the Irish Medical Association, 1971, Oct-21, Volume: 60, Issue:422 Topics: Anti-Arrhythmia Agents; Anxiety; Arrhythmias, Cardiac; Diazepam; Humans; Morphine; Myocardial Infarc	1971
[Effect of sedatives on pain threshold]. Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:10 Topics: Adult; Diazepam; Female; Humans; Hypnotics and Sedatives; Meperidine; Pain; Pentazocine; Pentobarbit	1971
[The stiff man syndrome]. Les Cahiers de medecine, 1971, Apr-15, Volume: 12, Issue:5 Topics: Diazepam; Electromyography; Female; Fibromyalgia; Humans; Middle Aged; Muscular Diseases; Pain; Tach	1971
Pain control in dentistry. Egyptian dental journal, 1971, Volume: 17, Issue:4 Topics: Anesthesia, Dental; Diazepam; Pain; Pentazocine; Prilocaine	1971
[Possibilities and limits of modification of symptoms in the spondylogenous syndrome with psychotropic substances]. Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1969, Volume: 1 Topics: Adult; Amitriptyline; Antidepressive Agents; Depression; Diazepam; Humans; Middle Aged; Pain; Rheuma	1969
[Use of tranquilizers in relief of postoperative pain]. Masui. The Japanese journal of anesthesiology, 1970, Volume: 19, Issue:12 Topics: Diazepam; Humans; Hydroxyzine; Meperidine; Pain; Postoperative Care; Tranquilizing Agents	1970
[Neuropsychotropic drugs in the treatment of so-called pain syndromes]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:7 Topics: Aminobutyrates; Benperidol; Chronic Disease; Diazepam; Humans; Hydantoins; Neuralgia; Pain; Procaina	1970
[Drug combinations in the treatment of pain in hemophiliacs]. Bibliotheca haematologica, 1966, Volume: 26 Topics: Analgesics; Child; Dextromoramide; Diazepam; Hemophilia A; Humans; Pain; Phenoperidine	1966
[Labor pain under the influence of Valium-Rocue and objective evaluation based on the algotocogram]. Geburtshilfe und Frauenheilkunde, 1966, Volume: 26, Issue:6 Topics: Anesthesia, Obstetrical; Diazepam; Female; Humans; Labor, Obstetric; Pain; Pregnancy; Uterus	1966

diazepam and Ache