diazepam has been researched along with Absence Status in 378 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous phenobarbital is frequently offered to patients with generalized convulsive status epilepticus (GCSE) in China, but its long-term benefits are unclear." | 9.69 | Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial. ( Chen, W; Huang, H; Jiang, M; Liu, G; Su, Y; Tian, F; Wang, Y; Zhang, Y, 2023) |
| "To explore the clinical efficacy of clonazepam in the treatment of status epilepticus." | 9.51 | Clinical efficacy of clonazepam in the treatment of status epilepticus. ( Fang, L; Tong, X; Wu, X; Xu, Y; Zhou, X, 2022) |
| "Diazepam is labeled for status epilepticus (SE) in children, but there are limited data characterizing its disposition in pediatric patients." | 9.27 | Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. ( Anand, R; Beechinor, RJ; Capparelli, EV; Chamberlain, JM; Cohen-Wolkowiez, M; Gonzalez, D; Guptill, JT; Harper, B; Hornik, CP; Ku, LC; Martz, K, 2018) |
| "To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus before intravenous access is available." | 9.24 | Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial. ( Bhatti, SFM; Charalambous, M; Gallucci, A; Gandini, G; Hasegawa, D; Ives, E; Jeffery, ND; Musteata, M; Platt, S; Siedenburg, J; Tipold, A; Van Ham, L; Vanhaesebrouck, AE; Volk, HA, 2017) |
| "This was a secondary analysis of the efficacy and safety results of the Pediatric Seizure Study, a randomized clinical trial of lorazepam versus diazepam for pediatric status epilepticus." | 9.24 | Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus. ( Chamberlain, DB; Chamberlain, JM, 2017) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 9.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 9.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| ") sodium valproate (VPA) for diazepam (DZP) refractory convulsive status epilepticus (CSE)." | 9.14 | Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. ( Chen, L; Feng, P; Liu, L; Wang, J; Zhou, D, 2009) |
| "To determine whether intravenous lorazepam is as efficacious as diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children." | 9.14 | Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial. ( Gupta, P; Krishnamurthy, S; Sharma, KK; Sreenath, TG, 2010) |
| "An open-label, randomized controlled study was conducted at a tertiary care teaching hospital to compare efficacy and safety of intravenous sodium valproate versus diazepam infusion for control of refractory status epilepticus." | 9.12 | Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. ( Mehta, V; Singhi, P; Singhi, S, 2007) |
| "The objective of this study was to compare the efficacy of continuous midazolam and diazepam infusion for the control of refractory status epilepticus." | 9.10 | Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. ( Jayashree, M; Murthy, A; Singhi, P; Singhi, S, 2002) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 9.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "In a randomized, nonblinded clinical trial, 36 consecutive patients with generalized convulsive status epilepticus were treated with either combination diazepam and phenytoin (DZ/DPH) or phenobarbital (PB)." | 9.06 | Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. ( Gabor, AJ; Herring, MO; McCurdy, SA; Shaner, DM, 1988) |
| "Lorazepam was compared with diazepam for the treatment of status epilepticus in a double-blind, randomized trial." | 9.05 | Double-blind study of lorazepam and diazepam in status epilepticus. ( Derivan, AT; Homan, RW; Leppik, IE; Patrick, B; Ramsay, RE; Walker, J, 1983) |
| "Midazolam, lorazepam, and diazepam were recommended as emergent initial therapy for status epilepticus." | 8.93 | A Comparison of Midazolam, Lorazepam, and Diazepam for the Treatment of Status Epilepticus in Children: A Network Meta-analysis. ( Fan, JC; Feng, K; Wang, HY; Wen, B; Yang, ZB; Zhao, ZY, 2016) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 8.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 8.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| " In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam." | 8.12 | Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 8.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| "To compare the efficacy of intravenous midazolam and diazepam in the management of status epilepticus seizures in children." | 8.02 | A comparison of intravenous midazolam and diazepam in management of status epilepticus in children. ( Abbas, G; Hanif, M; Kazmi, A; Khurshid, A; Mallhi, TH; Riaz, N; Saleem, U; Shah, A; Shah, S, 2021) |
| "We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting." | 8.02 | Blood concentration of levetiracetam after bolus administration in patients with status epilepticus. ( Hotta, M; Kaneko, J; Kondo, M; Kubota, M; Kuno, M; Nagano, M; Sugaya, K; Tagami, T; Takase, H; Unemoto, K, 2021) |
| "This open-label, prospective, multicenter study involved 34 Japanese children with status epilepticus unresponsive to diazepam." | 7.91 | Efficacy, safety, and pharmacokinetics of intravenous midazolam in Japanese children with status epilepticus. ( Fukuyama, T; Hamano, SI; Miki, M; Osawa, M; Sugai, K; Tabata, T, 2019) |
| "A protocol was developed to achieve status epilepticus (SE) resolution: step 1, intramuscular (IM) lorazepam; step 2, repeat IM lorazepam; step 3, rectal diazepam." | 7.85 | Intramuscular Lorazepam for Status Epilepticus in Children With Complex Medical and Physical Disabilities. ( Johnson, M; Johnson, PN; Neely, SB; Nguyen, A, 2017) |
| "To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE)." | 7.85 | Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. ( Klitgaard, H; Matagne, A; Niquet, J; Suchomelova, L; Thompson, K; Wasterlain, C, 2017) |
| "Clinical question Is intravenous (IV) lorazepam superior to IV diazepam in the treatment of pediatric status epilepticus? Article chosen Chamberlain JM, Okada P, Holsti M, et al." | 7.83 | Lorazepam v. diazepam for pediatric status epilepticus. ( Pinto, RF; Turnbull, J, 2016) |
| " During status epilepticus, ACh levels were increased threefold but returned to baseline after the termination of seizures by diazepam." | 7.83 | Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats. ( Imran, I; Klein, J; Lietsche, J, 2016) |
| "Our data demonstrate an anticonvulsant effect of bumetanide on KA-induced seizures in adult mice, suggesting a role for chloride plasticity in seizure progression." | 7.83 | Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. ( Maguire, J; Sivakumaran, S, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming." | 7.81 | Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. ( Gunshin, M; Inokuchi, R; Kitsuta, Y; Nakajima, S; Nakamura, K; Ohashi-Fukuda, N; Wada, T; Yahagi, N, 2015) |
| "To assess the efficacy of intravenous (IV) levetiracetam (LEV) in the treatment of status epilepticus (SE) and treatment outcomes." | 7.81 | Intravenous levetiracetam treatment in status epilepticus: A prospective study. ( Atmaca, MM; Bebek, N; Gurses, C; Orhan, EK, 2015) |
| "Oral diazepam, administered in varying doses, is among the few proposed treatment options for electrical status epilepticus during slow wave sleep in children." | 7.80 | Medical management with diazepam for electrical status epilepticus during slow wave sleep in children. ( Eksioglu, Y; Francois, D; Hess, S; Probst, L; Roberts, J, 2014) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 7.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 7.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 7.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| "We describe the short-term effects of high-dose oral diazepam on sleep-potentiated epileptiform activity in patients with electric status epilepticus during sleep." | 7.78 | Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. ( Abdelmoumen, I; Eksioglu, Y; Hadjiloizou, S; Kothare, SV; Loddenkemper, T; Peters, JM; Riviello, JJ; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Tas, E, 2012) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 7.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 7.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 7.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| " The pharmacokinetic data favor use of IL instead of its principal therapeutic alternative (injectable diazepam) but no currently available evidence concludes that IL is superior to diazepam in the management of pediatric status epilepticus." | 7.76 | [Use of injectable lorazepam in status epilepticus: a comparative study in French-speaking hospitals]. ( Auvin, S; Bourdon, O; Brion, F; Curatolo, N; Prot-Labarthe, S; Sachs, P, 2010) |
| "In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated." | 7.76 | The control of kainic acid-induced status epilepticus. ( Clinckers, R; Massie, A; Michotte, Y; Smolders, I; Vermoesen, K, 2010) |
| "Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus." | 7.75 | Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. ( Cunha, AO; dos Santos, WF; Liberato, JL; Mortari, MR, 2009) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 7.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 7.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 7.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| "Exposure to the organophosphate nerve agent soman produces seizures that in turn lead to neuropathology." | 7.73 | Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging. ( Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A, 2005) |
| "To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide." | 7.73 | Nonconvulsive status epilepticus due to ifosfamide. ( Akoglu, H; Aksoy, S; Cakar, M; Erman, M; Kilickap, S; Onal, IK; Tekuzman, G; Tufan, A, 2006) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 7.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 7.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "The aim of this study was to determine the effect of the duration of pilocarpine-induced status epilepticus (SE) on subsequent cognitive function in rats." | 7.71 | Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats. ( Balakrishnan, S; Nidhi, G; Pandhi, P, 2001) |
| "Previous trials have suggested lorazepam may be superior to diazepam as first-line treatment of convulsive status epilepticus (CSE), with improved seizure outcome, and a lower incidence of side-effects." | 7.71 | A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus. ( Cock, HR; Schapira, AH, 2002) |
| "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus." | 7.70 | Refractory status epilepticus in children: role of continuous diazepam infusion. ( Banerjee, S; Singhi, P; Singhi, S, 1998) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 7.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 7.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 7.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "To compare the feasibility, effectiveness, and safety of rectal diazepam and intravenous diazepam in the treatment of pediatric prehospital status epilepticus." | 7.69 | Rectal diazepam for prehospital pediatric status epilepticus. ( Dieckmann, RA, 1994) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 7.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| "Lidocaine (lignocaine) was given in 42 episodes of status epilepticus (SE) in 36 patients either because of limited pulmonary reserve (22 patients) or because of lack of response to diazepam (14 patients)." | 7.68 | Role of lidocaine (lignocaine) in managing status epilepticus. ( Berciano, J; Ciudad, J; Pascual, J, 1992) |
| "Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine." | 7.67 | Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. ( Treiman, DM; Walton, NY, 1988) |
| "The ability of various drugs to prevent the onset of status epilepticus induced by administration of the muscarinic agonist, pilocarpine, to lithium-pretreated rats was determined." | 7.67 | Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "Subcutaneous administration of pilocarpine to rats that were pretreated with a small dose of lithium chloride results in the evolution of generalized convulsive status epilepticus." | 7.67 | Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1986) |
| "Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG." | 7.66 | Rectal diazepam in the treatment of absence status: a pharmacodynamic study. ( Dhillon, S; Milligan, N; Oxley, J; Richens, A, 1981) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 7.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| "Diazepam was initially administered, followed intravenously by FPHT at 22." | 7.30 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial. ( Asami, M; Egawa, S; Fukuda, Y; Hoshiyama, E; Inoue, Y; Ishikawa, E; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Matsumaru, Y; Mochizuki, M; Nakamoto, H; Nakamura, K; Takahashi, Y; Uchida, M; Unemoto, K; Yamada, T; Yonekawa, C, 2023) |
| "Levetiracetam reportedly has similar efficacy and higher safety for SE; however, evidence to support its use for adult SE is lacking." | 7.01 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial. ( Asami, M; Egawa, S; Hoshiyama, E; Inoue, Y; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Nakamura, K; Takahashi, Y; Yamada, T; Yonekawa, C, 2021) |
| " Safety evaluations included respiratory depression and the frequency of treatment-emergent adverse events (TEAEs)." | 7.01 | A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects. ( Benitez, A; Fournier, M; Kugler, AR; Takeda, S; Yoshinaga, H, 2021) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 6.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 6.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 6.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| "An inhaled benzodiazepine as a seizure rescue drug is currently undergoing clinical trials." | 6.72 | A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures. ( Higdon, LM; Sperling, MR, 2021) |
| "Midazolam was given 0." | 6.70 | Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. ( Al Riyami, K; Chacko, A; Javed, H; Koul, R, 2002) |
| "Lorazepam is likely to be a better therapy than diazepam." | 6.70 | A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. ( Alldredge, BK; Allen, F; Corry, MD; Gelb, AM; Gottwald, MD; Isaacs, SM; Lowenstein, DH; Neuhaus, JM; O'Neil, N; Segal, MR; Ulrich, S, 2001) |
| "Prompt treatment of status epilepticus (SE) is associated with better outcomes." | 6.52 | Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis. ( Brigo, F; Nardone, R; Tezzon, F; Trinka, E, 2015) |
| "Midazolam was administered faster than diazepam (mean difference = 2." | 6.46 | Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. ( McMullan, J; Pancioli, A; Sasson, C; Silbergleit, R, 2010) |
| " The Encephalitis-Nonconvulsive Status Epilepticus-Diazepam Resistance-Image Abnormalities-Tracheal Intubation (END-IT) score was a useful tool for predicting the functional outcomes of CSE patients, excluding cerebral hypoxia patients." | 5.69 | Development and validation of a nomogram to provide individualized predictions of functional outcomes in patients with convulsive status epilepticus at 3 months: The modified END-IT tool. ( Gao, Q; Jiang, W; Kang, XG; Song, CG; Wan, J; Wang, X; Wang, YY; Wei, JY; Yang, F; Zhang, YY, 2023) |
| "Intravenous phenobarbital is frequently offered to patients with generalized convulsive status epilepticus (GCSE) in China, but its long-term benefits are unclear." | 5.69 | Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial. ( Chen, W; Huang, H; Jiang, M; Liu, G; Su, Y; Tian, F; Wang, Y; Zhang, Y, 2023) |
| "To explore the clinical efficacy of clonazepam in the treatment of status epilepticus." | 5.51 | Clinical efficacy of clonazepam in the treatment of status epilepticus. ( Fang, L; Tong, X; Wu, X; Xu, Y; Zhou, X, 2022) |
| " This study is aimed to evaluate the ability of DDS, alone or in combination with DZP starting their administration once the SE is onset to evaluate the control of seizures in rats." | 5.51 | Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats. ( Baron-Flores, V; Caballero-Chacón, S; Díaz-Ruiz, A; Farfán-Briseño, AC; Franco-Pérez, J; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Nava-Ruiz, C; Ríos, C; Ruiz-Diaz, A, 2019) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 5.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| "Oral diazepam was well-tolerated with no major side effects." | 5.48 | Diazepam for outpatient treatment of nonconvulsive status epilepticus in pediatric patients with Angelman syndrome. ( Chan, F; Grocott, O; Thibert, R; Tourjee, A; Worden, L, 2018) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 5.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| " Diazepam rectal gel, intranasal midazolam, and diazepam nasal spray are US Food and Drug Administration (FDA)-approved seizure-cluster rescue medications, and intravenous diazepam and lorazepam are approved for status epilepticus." | 5.41 | Acute Abortive Therapies for Seizure Clusters in Long-Term Care. ( Becker, DA; Birnbaum, AK; Carrazana, E; Misra, SN; Rabinowicz, AL; Ramsay, RE; Vazquez, B, 2023) |
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 5.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies." | 5.39 | A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus. ( Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B, 2013) |
| "Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug." | 5.36 | Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 5.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 5.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "Levetiracetam (LEV) is a structurally novel antiepileptic drug (AED) which has demonstrated a broad spectrum of anticonvulsant activities both in experimental and clinical studies." | 5.34 | Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. ( Bethmann, K; Brandt, C; Fedrowitz, M; Gastens, AM; Glien, M; Löscher, W; Potschka, H; Volk, HA, 2007) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 5.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "Diazepam rectal gel was given more quickly and reliably, reducing total seizure time, potential neuronal injury and other complications." | 5.32 | Treatment of out-of-hospital status epilepticus with diazepam rectal gel. ( Fitzgerald, BJ; Miller, JW; Okos, AJ, 2003) |
| "Dizocilpine maleate-pretreated animals responded rapidly to diazepam treatment, even after 60 min of status epilepticus." | 5.30 | N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. ( DeLorenzo, RJ; Rice, AC, 1999) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "Pretreatment with diazepam alone did reduce soman-induced seizures but did not reduce mortality of rats." | 5.29 | [Prevention and treatment of status epilepticus induced by soman]. ( Blanchet, G; Carpentier, P; Lallement, G; Sentenac-Roumanou, H, 1994) |
| "In 75 occasions, the convulsion stopped within a period of 2 to 5 minutes, in 12 other times there was a need for repeated dosages and in 2 occasions, a third doses was needed." | 5.28 | [Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents]. ( Calderón González, R, 1991) |
| "Status epilepticus is a neurologic emergency with an 8% to 12% mortality." | 5.28 | Rectal diazepam in pediatric status epilepticus. ( Albano, A; Reisdorff, EJ; Wiegenstein, JG, 1989) |
| "Diazepam is labeled for status epilepticus (SE) in children, but there are limited data characterizing its disposition in pediatric patients." | 5.27 | Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus. ( Anand, R; Beechinor, RJ; Capparelli, EV; Chamberlain, JM; Cohen-Wolkowiez, M; Gonzalez, D; Guptill, JT; Harper, B; Hornik, CP; Ku, LC; Martz, K, 2018) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 5.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus before intravenous access is available." | 5.24 | Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial. ( Bhatti, SFM; Charalambous, M; Gallucci, A; Gandini, G; Hasegawa, D; Ives, E; Jeffery, ND; Musteata, M; Platt, S; Siedenburg, J; Tipold, A; Van Ham, L; Vanhaesebrouck, AE; Volk, HA, 2017) |
| "This was a secondary analysis of the efficacy and safety results of the Pediatric Seizure Study, a randomized clinical trial of lorazepam versus diazepam for pediatric status epilepticus." | 5.24 | Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus. ( Chamberlain, DB; Chamberlain, JM, 2017) |
| " Head-to-head trials comparing buccal versus intranasal midazolam versus rectal diazepam would provide useful information to inform the management of the first stage of convulsive status epilepticus in adults, especially when intravenous or intramuscular access is not feasible." | 5.22 | Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence. ( Aucott, L; Booth, C; Brazzelli, M; Counsell, C; Cruickshank, M; Imamura, M; Manson, P; Scotland, G, 2022) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 5.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 5.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| ") sodium valproate (VPA) for diazepam (DZP) refractory convulsive status epilepticus (CSE)." | 5.14 | Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus. ( Chen, L; Feng, P; Liu, L; Wang, J; Zhou, D, 2009) |
| "To determine whether intravenous lorazepam is as efficacious as diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children." | 5.14 | Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial. ( Gupta, P; Krishnamurthy, S; Sharma, KK; Sreenath, TG, 2010) |
| " Randomized controlled/prospective randomized trials comparing IN midazolam against IV/rectal BDZ in the treatment of acute seizures in pediatric patients were included in the meta-analysis." | 5.12 | Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis. ( Chhabra, R; Gupta, LK; Gupta, R, 2021) |
| "An open-label, randomized controlled study was conducted at a tertiary care teaching hospital to compare efficacy and safety of intravenous sodium valproate versus diazepam infusion for control of refractory status epilepticus." | 5.12 | Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. ( Mehta, V; Singhi, P; Singhi, S, 2007) |
| "Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus." | 5.11 | Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children. ( Mahmoudian, T; Zadeh, MM, 2004) |
| "The objective of this study was to compare the efficacy of continuous midazolam and diazepam infusion for the control of refractory status epilepticus." | 5.10 | Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. ( Jayashree, M; Murthy, A; Singhi, P; Singhi, S, 2002) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 5.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin." | 5.08 | A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. ( Calabrese, VP; Colling, C; Collins, JF; Faught, E; Handforth, A; Mamdani, MB; Meyers, PD; Ramsay, RE; Rowan, AJ; Treiman, DM; Uthman, BM; Walton, NY, 1998) |
| "In a randomized, nonblinded clinical trial, 36 consecutive patients with generalized convulsive status epilepticus were treated with either combination diazepam and phenytoin (DZ/DPH) or phenobarbital (PB)." | 5.06 | Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. ( Gabor, AJ; Herring, MO; McCurdy, SA; Shaner, DM, 1988) |
| "Lorazepam was compared with diazepam for the treatment of status epilepticus in a double-blind, randomized trial." | 5.05 | Double-blind study of lorazepam and diazepam in status epilepticus. ( Derivan, AT; Homan, RW; Leppik, IE; Patrick, B; Ramsay, RE; Walker, J, 1983) |
| "Midazolam, lorazepam, and diazepam were recommended as emergent initial therapy for status epilepticus." | 4.93 | A Comparison of Midazolam, Lorazepam, and Diazepam for the Treatment of Status Epilepticus in Children: A Network Meta-analysis. ( Fan, JC; Feng, K; Wang, HY; Wen, B; Yang, ZB; Zhao, ZY, 2016) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 4.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| "Lorazepam is better than diazepam or phenytoin alone for cessation of seizures and carries a lower risk of continuation of status epilepticus requiring a different drug or general anaesthesia." | 4.84 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, K; Sequeira, R, 2007) |
| "Lorazepam is better than diazepam or phenytoin alone for cessation of seizures and carries a lower risk of continuation of status epilepticus requiring a different drug or general anaesthesia." | 4.82 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, K; Sequeira, R, 2005) |
| "To review the evidence comparing diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children." | 4.81 | Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. ( Appleton, R; Martland, T; Phillips, B, 2002) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| " A family history of seizures and a prescription for rectal diazepam were associated with a decreased likelihood of progression to RSE." | 4.31 | Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children. ( Abend, NS; Amengual-Gual, M; Anderson, A; Appavu, BL; Arya, R; Barcia Aguilar, C; Brenton, JN; Carpenter, J; Chapman, KE; Clark, J; Gaillard, WD; Gaínza-Lein, M; Glauser, T; Goldstein, J; Goodkin, H; Grinspan, Z; Guerriero, RM; Horn, PS; Huh, L; Kahoud, R; Kapur, K; Kelley, SA; Kossoff, EH; Lai, YC; Loddenkemper, T; Marquis, BO; McDonough, T; Mikati, MA; Morgan, L; Novotny, E; Ostendorf, AP; Payne, ET; Peariso, K; Piantino, J; Riviello, J; Sands, T; Stafstrom, CE; Tasker, RC; Tchapyjnikov, D; Vasquez, A; Wainwright, MS; Wilfong, A; Williams, K, 2023) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 4.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| " In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam." | 4.12 | Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 4.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| "To compare the efficacy of intravenous midazolam and diazepam in the management of status epilepticus seizures in children." | 4.02 | A comparison of intravenous midazolam and diazepam in management of status epilepticus in children. ( Abbas, G; Hanif, M; Kazmi, A; Khurshid, A; Mallhi, TH; Riaz, N; Saleem, U; Shah, A; Shah, S, 2021) |
| "We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting." | 4.02 | Blood concentration of levetiracetam after bolus administration in patients with status epilepticus. ( Hotta, M; Kaneko, J; Kondo, M; Kubota, M; Kuno, M; Nagano, M; Sugaya, K; Tagami, T; Takase, H; Unemoto, K, 2021) |
| " Our study aims to assess if administering lorazepam, for convulsive seizures <5 min, causes vital instability." | 3.96 | Lorazepam timing for acute convulsive seizure control (LoTASC). ( Gopal, M; Greene-Chandos, D; Hamed, M; Hussein, O; Kamdar, HA; Peters, E; Sawalha, K; Shanmugam, K; Smetana, KS; Thakur, G; Yasin, R, 2020) |
| "This open-label, prospective, multicenter study involved 34 Japanese children with status epilepticus unresponsive to diazepam." | 3.91 | Efficacy, safety, and pharmacokinetics of intravenous midazolam in Japanese children with status epilepticus. ( Fukuyama, T; Hamano, SI; Miki, M; Osawa, M; Sugai, K; Tabata, T, 2019) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| "A protocol was developed to achieve status epilepticus (SE) resolution: step 1, intramuscular (IM) lorazepam; step 2, repeat IM lorazepam; step 3, rectal diazepam." | 3.85 | Intramuscular Lorazepam for Status Epilepticus in Children With Complex Medical and Physical Disabilities. ( Johnson, M; Johnson, PN; Neely, SB; Nguyen, A, 2017) |
| "To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE)." | 3.85 | Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. ( Klitgaard, H; Matagne, A; Niquet, J; Suchomelova, L; Thompson, K; Wasterlain, C, 2017) |
| "A 19-year-old male came to the Emergency Room of our hospital due to an episode of dystonic movements and disorientation 4 days after consuming methamphetamine, which evolved to a catatonic frank syndrome and eventually to status epilepticus." | 3.85 | Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis. ( Aguilera, L; García, JM; Iriondo, O; Rodríguez, T; Zaldibar-Gerrikagoitia, J, 2017) |
| "Clinical question Is intravenous (IV) lorazepam superior to IV diazepam in the treatment of pediatric status epilepticus? Article chosen Chamberlain JM, Okada P, Holsti M, et al." | 3.83 | Lorazepam v. diazepam for pediatric status epilepticus. ( Pinto, RF; Turnbull, J, 2016) |
| " During status epilepticus, ACh levels were increased threefold but returned to baseline after the termination of seizures by diazepam." | 3.83 | Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats. ( Imran, I; Klein, J; Lietsche, J, 2016) |
| "Our data demonstrate an anticonvulsant effect of bumetanide on KA-induced seizures in adult mice, suggesting a role for chloride plasticity in seizure progression." | 3.83 | Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. ( Maguire, J; Sivakumaran, S, 2016) |
| "Intravenous diazepam has been a first-line therapy to stop seizures in children for many years." | 3.83 | Intranasal midazolam for seizure cessation in the community setting. ( Goldman, RD; Zelcer, M, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming." | 3.81 | Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. ( Gunshin, M; Inokuchi, R; Kitsuta, Y; Nakajima, S; Nakamura, K; Ohashi-Fukuda, N; Wada, T; Yahagi, N, 2015) |
| "Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors." | 3.81 | Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. ( Apland, JP; Chen, J; Grunberg, N; Marini, AM; McDonough, J; Pan, H; Piermartiri, TC, 2015) |
| "To assess the efficacy of intravenous (IV) levetiracetam (LEV) in the treatment of status epilepticus (SE) and treatment outcomes." | 3.81 | Intravenous levetiracetam treatment in status epilepticus: A prospective study. ( Atmaca, MM; Bebek, N; Gurses, C; Orhan, EK, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "Status epilepticus in children was characterized by heterogeneous etiology, prolonged duration and commonly good response to midazolam only given in high doses." | 3.81 | Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus. ( Djuric, M; Jankovic, B; Kravljanac, R; Pekmezovic, T, 2015) |
| "Oral diazepam, administered in varying doses, is among the few proposed treatment options for electrical status epilepticus during slow wave sleep in children." | 3.80 | Medical management with diazepam for electrical status epilepticus during slow wave sleep in children. ( Eksioglu, Y; Francois, D; Hess, S; Probst, L; Roberts, J, 2014) |
| "To evaluate the efficacy and safety of a simple linear midazolam-based protocol for the management of impending status epilepticus in children up to 18 years of age." | 3.80 | Quality assurance evaluation of a simple linear protocol for the treatment of impending status epilepticus in a pediatric emergency department 2 years postimplementation. ( Diksic, D; McGillivray, D; Mok, E; Tourigny-Ruel, G, 2014) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 3.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 3.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| " We are interested in treatment of SE under hyponatremia, and have here evaluated whether SE induced by systemic kainic acid could be a suitable platform for such studies." | 3.79 | Hyponatremia augments kainic-acid induced status epilepticus in the mouse: a model for dysmetabolic status epilepticus. ( Clausen, F; Halawa, I; Kumlien, E; Zelano, J, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 3.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| "We describe the short-term effects of high-dose oral diazepam on sleep-potentiated epileptiform activity in patients with electric status epilepticus during sleep." | 3.78 | Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. ( Abdelmoumen, I; Eksioglu, Y; Hadjiloizou, S; Kothare, SV; Loddenkemper, T; Peters, JM; Riviello, JJ; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Tas, E, 2012) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 3.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 3.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 3.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| "Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted." | 3.76 | A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. ( Bertram, E; de Haan, GJ; Doelman, G; Edelbroek, P; van der Geest, P, 2010) |
| " The pharmacokinetic data favor use of IL instead of its principal therapeutic alternative (injectable diazepam) but no currently available evidence concludes that IL is superior to diazepam in the management of pediatric status epilepticus." | 3.76 | [Use of injectable lorazepam in status epilepticus: a comparative study in French-speaking hospitals]. ( Auvin, S; Bourdon, O; Brion, F; Curatolo, N; Prot-Labarthe, S; Sachs, P, 2010) |
| "In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated." | 3.76 | The control of kainic acid-induced status epilepticus. ( Clinckers, R; Massie, A; Michotte, Y; Smolders, I; Vermoesen, K, 2010) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| "Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus." | 3.75 | Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. ( Cunha, AO; dos Santos, WF; Liberato, JL; Mortari, MR, 2009) |
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 3.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 3.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 3.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| "Partial limbic seizures in rodents induced by pilocarpine progress from stages I-II (mouth and facial movements; head nodding) to stage III (forelimb clonus) and then progress rapidly to stages IV-V (generalized limbic seizures; rearing, and rearing with falling) followed by status epilepticus (SE)." | 3.74 | Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. ( Feng, HJ; Kao, C; Macdonald, RL; Mathews, GC, 2008) |
| "We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats." | 3.74 | Effective treatments of prolonged status epilepticus in developing rats. ( Hasson, H; Kim, M; Moshé, SL, 2008) |
| "Exposure to the organophosphate nerve agent soman produces seizures that in turn lead to neuropathology." | 3.73 | Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging. ( Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A, 2005) |
| "We studied the effects of treating status epilepticus (SE) induced by lithium and pilocarpine at postnatal day 15 (P15) or 28 (P28), on the severity of acute SE and of SE-induced epileptogenesis." | 3.73 | Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. ( Baldwin, RA; Kubova, H; Sankar, R; Suchomelova, L; Thompson, KW; Wasterlain, CG, 2006) |
| "To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide." | 3.73 | Nonconvulsive status epilepticus due to ifosfamide. ( Akoglu, H; Aksoy, S; Cakar, M; Erman, M; Kilickap, S; Onal, IK; Tekuzman, G; Tufan, A, 2006) |
| "Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)." | 3.73 | The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 3.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "Diazepam (DZP) is one of the most commonly prescribed drugs for treating status epilepticus (SE)." | 3.72 | Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid. ( Fenyk-Melody, J; Pivnichny, JV; Shen, X; Tong, X; Wang, J, 2003) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 3.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "The aim of this study was to determine the effect of the duration of pilocarpine-induced status epilepticus (SE) on subsequent cognitive function in rats." | 3.71 | Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats. ( Balakrishnan, S; Nidhi, G; Pandhi, P, 2001) |
| "Previous trials have suggested lorazepam may be superior to diazepam as first-line treatment of convulsive status epilepticus (CSE), with improved seizure outcome, and a lower incidence of side-effects." | 3.71 | A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus. ( Cock, HR; Schapira, AH, 2002) |
| "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus." | 3.70 | Refractory status epilepticus in children: role of continuous diazepam infusion. ( Banerjee, S; Singhi, P; Singhi, S, 1998) |
| "To determine whether repeat boluses of diazepam (DZP) lead to significant accumulation in the central nervous system and/or peripheral compartments, as repeat intravenous boluses of diazepam are commonly used in the treatment of status epilepticus (SE)." | 3.70 | Comparison of single- and repeated-dose pharmacokinetics of diazepam. ( Brown, S; Patsalos, PN; Shorvon, SD; Tong, X; Walker, MC, 1998) |
| "An animal model of self-sustaining status epilepticus (SSSE) induced in rats by brief intermittent perforant path stimulation (PPS) was examined with regard to the effects of two conventional antiepileptic drugs, diazepam and phenytoin." | 3.70 | Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus. ( Baldwin, RA; Mazarati, AM; Sankar, R; Wasterlain, CG, 1998) |
| " This report describes a near-hanging episode in a patient who subsequently had status epilepticus requiring 40 mg of diazepam and 1,200 mg of phenytoin for control in the prehospital and emergency department stabilization period." | 3.70 | Hanging-induced status epilepticus. ( Pesola, GR; Westfal, RE, 1999) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 3.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 3.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 3.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "Diazepam is administered to children in status epilepticus by paramedics in many Emergency Medical Services systems throughout the United States despite the lack of clear evidence that this therapy is safe and effective when employed in the prehospital environment." | 3.69 | Effect of prehospital treatment on the outcome of status epilepticus in children. ( Alldredge, BK; Ferriero, DM; Wall, DB, 1995) |
| "Six hundred and ninety-four members of the Intensive Care Society working in the UK were surveyed by postal questionnaire between May and November 1993 to determine their management of convulsive status epilepticus resistant to initial therapy with intravenous diazepam and phenytoin." | 3.69 | The intensive care treatment of convulsive status epilepticus in the UK. Results of a national survey and recommendations. ( Shorvon, SD; Smith, SJ; Walker, MC, 1995) |
| "Status epilepticus was induced in rats by sequential injections of lithium and pilocarpine." | 3.69 | Cardiac hypertrophy secondary to status epilepticus in the rat. ( Rubinstein, BK; Treiman, DM; Walton, NY, 1995) |
| "We studied the efficacy of the competitive NMDA receptor antagonist CGP 40116 in protecting against seizure-induced neuronal necrosis from lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. ( Daniels, AH; Fujikawa, DG; Kim, JS, 1994) |
| "To compare the feasibility, effectiveness, and safety of rectal diazepam and intravenous diazepam in the treatment of pediatric prehospital status epilepticus." | 3.69 | Rectal diazepam for prehospital pediatric status epilepticus. ( Dieckmann, RA, 1994) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 3.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| "We describe a novel model of status epilepticus produced by the focal application of bicuculline methiodide into the deep prepiriform cortex of rats pretreated with lithium chloride." | 3.68 | A rodent model of focally evoked self-sustaining status epilepticus. ( Gale, K; Pazos, A; Peterson, CJ; Vinayak, S, 1992) |
| "Lidocaine (lignocaine) was given in 42 episodes of status epilepticus (SE) in 36 patients either because of limited pulmonary reserve (22 patients) or because of lack of response to diazepam (14 patients)." | 3.68 | Role of lidocaine (lignocaine) in managing status epilepticus. ( Berciano, J; Ciudad, J; Pascual, J, 1992) |
| "The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde." | 3.67 | Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989) |
| "Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine." | 3.67 | Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam. ( Treiman, DM; Walton, NY, 1988) |
| "The ability of various drugs to prevent the onset of status epilepticus induced by administration of the muscarinic agonist, pilocarpine, to lithium-pretreated rats was determined." | 3.67 | Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1987) |
| "Subcutaneous administration of pilocarpine to rats that were pretreated with a small dose of lithium chloride results in the evolution of generalized convulsive status epilepticus." | 3.67 | Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. ( Jope, RS; Morrisett, RA; Snead, OC, 1986) |
| "Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG." | 3.66 | Rectal diazepam in the treatment of absence status: a pharmacodynamic study. ( Dhillon, S; Milligan, N; Oxley, J; Richens, A, 1981) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 3.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| "Intra-amygdaloid unilateral application of low doses of kainic acid rapidly elicits, in both chronic and acute conditions, secondarily generalized convulsive seizures which often culminate in fatal true status epilepticus unless appropriate anti-epileptic drugs are provided." | 3.66 | [Epileptogenic action of intra-amygdaloid injection of kainic acid]. ( Ben-Ari, Y; Lagowska, J, 1978) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| "Diazepam was initially administered, followed intravenously by FPHT at 22." | 3.30 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial. ( Asami, M; Egawa, S; Fukuda, Y; Hoshiyama, E; Inoue, Y; Ishikawa, E; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Matsumaru, Y; Mochizuki, M; Nakamoto, H; Nakamura, K; Takahashi, Y; Uchida, M; Unemoto, K; Yamada, T; Yonekawa, C, 2023) |
| "Lorazepam was most frequently administered intravenously in the emergency department, midazolam intramuscularly or intravenously by the emergency medical services personnel, and diazepam rectally prior to ambulance arrival." | 3.01 | Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial. ( Bleck, TP; Chamberlain, JM; Cloyd, JC; Cock, HR; Coles, LD; Conwit, RA; Elm, JJ; Fountain, NB; Kapur, J; Lowenstein, DH; Rosenthal, ES; Sathe, AG; Shinnar, S; Silbergleit, R; Underwood, E, 2021) |
| "Levetiracetam reportedly has similar efficacy and higher safety for SE; however, evidence to support its use for adult SE is lacking." | 3.01 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial. ( Asami, M; Egawa, S; Hoshiyama, E; Inoue, Y; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Nakamura, K; Takahashi, Y; Yamada, T; Yonekawa, C, 2021) |
| " Safety evaluations included respiratory depression and the frequency of treatment-emergent adverse events (TEAEs)." | 3.01 | A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects. ( Benitez, A; Fournier, M; Kugler, AR; Takeda, S; Yoshinaga, H, 2021) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 2.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus." | 2.82 | Rescue therapies for seizure clusters: Pharmacology and target of treatments. ( Detyniecki, K; Gidal, B, 2022) |
| "Diazepam rectal gel is an effective rescue therapy for seizure clusters, though adults and adolescents may have social reservations regarding its administration." | 2.82 | Rescue Treatments for Seizure Clusters. ( Gidal, BE; Kotloski, RJ, 2022) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 2.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 2.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| "However, most seizure emergencies start outside the hospital settings." | 2.72 | Rescue therapies for seizure emergencies: current and future landscape. ( Samanta, D, 2021) |
| "An inhaled benzodiazepine as a seizure rescue drug is currently undergoing clinical trials." | 2.72 | A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures. ( Higdon, LM; Sperling, MR, 2021) |
| "Midazolam was given 0." | 2.70 | Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. ( Al Riyami, K; Chacko, A; Javed, H; Koul, R, 2002) |
| "Lorazepam is likely to be a better therapy than diazepam." | 2.70 | A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. ( Alldredge, BK; Allen, F; Corry, MD; Gelb, AM; Gottwald, MD; Isaacs, SM; Lowenstein, DH; Neuhaus, JM; O'Neil, N; Segal, MR; Ulrich, S, 2001) |
| "Prompt treatment of status epilepticus (SE) is associated with better outcomes." | 2.52 | Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis. ( Brigo, F; Nardone, R; Tezzon, F; Trinka, E, 2015) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Status epilepticus is defined as epileptic seizure with the duration for over 30 min or clustered seizure without complete recovery of consciousness for 30 min or more." | 2.50 | [Treatment of status epilepticus]. ( Yamanouchi, H, 2014) |
| "Diazepam gel was better than placebo gel in reducing the risk of non-cessation of seizures (RR 0." | 2.50 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, M; Sequeira, R, 2014) |
| "Febrile seizures are the most common type of childhood seizures, affecting 2% to 5% of children." | 2.49 | Complex febrile seizures: a practical guide to evaluation and treatment. ( Patel, AD; Vidaurre, J, 2013) |
| "Midazolam was administered faster than diazepam (mean difference = 2." | 2.46 | Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. ( McMullan, J; Pancioli, A; Sasson, C; Silbergleit, R, 2010) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Diazepam was significantly less efficacious than other treatments (P = ." | 2.40 | Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. ( Gartside, PS; Gilbert, DL; Glauser, TA, 1999) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| " In addition to physiologic factors, such as blood pressure and cerebral blood flow, pharmacokinetic principles, including half-life, distribution, elimination, and volume of distribution (with special regard to an agent's lipid-solubility rating), should be applied." | 2.38 | The pharmacokinetics of agents used to treat status epilepticus. ( Browne, TR, 1990) |
| " Differences in pharmacokinetic parameters, therefore, will influence the choice of drug." | 2.38 | Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus. ( Treiman, DM, 1989) |
| "Status epilepticus is a medical emergency that requires rapid seizure control." | 2.37 | Constant diazepam infusion in the treatment of continuous seizure activity. ( Bell, HE; Bertino, JS, 1984) |
| "Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
| "Drug treatment of status epilepticus is reviewed." | 2.36 | Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978) |
| "Introduction." | 1.91 | Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires. ( Álvarez Ricciardi, MB; Aprea, V; Fustiñana, A; Hansen, J; Kohn Loncarica, G; Nuñez, P; Oviedo, S; Piantino, J; Rino, P, 2023) |
| "Only diazepam significantly increased seizure freedom." | 1.72 | Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs. ( Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS, 2022) |
| "None presented afebrile seizures." | 1.72 | Non-convulsive febrile status epilepticus mimicking a postictal state after a febrile seizure: an ictal electroclinical and evolutive study. ( Bernardina, BD; Cantalupo, G; Darra, F; Fiorini, E; Fontana, E; Lo Barco, T; Meneghello, L; Proietti, J, 2022) |
| "Generalized convulsive status epilepticus is defined as a generalized and convulsive seizure with 5 minutes or more of continuous clinical and/or electrographic seizure activity or recurrent seizure activity without recovery between seizures." | 1.62 | Generalized convulsive status epilepticus after retrograde type A aortic dissection surgery. ( Chen, D; Li, Y; Shi, H; Wu, Q; Zhang, C, 2021) |
| "This study examined childhood seizure treatment in a rural area in Japan." | 1.62 | Initial treatment of seizures in children in an emergency department in rural Japan. ( Ando, H; Kido, S; Kidokoro, H; Natsume, J; Shiraki, A; Takahashi, Y; Yasui, M, 2021) |
| "Status epilepticus is defined as a state of unrelenting seizure activity." | 1.51 | Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. ( Akerman, CJ; Burman, RJ; Calin, A; Codadu, NK; Katz, AA; Lee, JH; Newey, SE; Parrish, RR; Raimondo, JV; Selfe, JS; Trevelyan, AJ; van den Berg, M; Wilmshurst, JM; Wright, R, 2019) |
| " This study is aimed to evaluate the ability of DDS, alone or in combination with DZP starting their administration once the SE is onset to evaluate the control of seizures in rats." | 1.51 | Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats. ( Baron-Flores, V; Caballero-Chacón, S; Díaz-Ruiz, A; Farfán-Briseño, AC; Franco-Pérez, J; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Nava-Ruiz, C; Ríos, C; Ruiz-Diaz, A, 2019) |
| " Medication dosing generally followed standard dosing guidelines with very few exceptions." | 1.51 | Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium. ( Payne, E; Wallace, A; Wirrell, E, 2019) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| "Kainic acid was used to create an animal model of SE." | 1.48 | Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats. ( Asai, Y; Katoh, M; Nadai, M; Tanaka, H, 2018) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 1.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| "Oral diazepam was well-tolerated with no major side effects." | 1.48 | Diazepam for outpatient treatment of nonconvulsive status epilepticus in pediatric patients with Angelman syndrome. ( Chan, F; Grocott, O; Thibert, R; Tourjee, A; Worden, L, 2018) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 1.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 1.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life." | 1.39 | Prolonged febrile seizures, clinical characteristics, and acute management. ( Barzilay, M; Bassan, H; Gross-Tsur, V; Matoth, I; Shinnar, S; Shorer, Z, 2013) |
| "Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies." | 1.39 | A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus. ( Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B, 2013) |
| "Diazepam (10mg/kg) was administered 10min and 30min after the onset of continuous EEG seizures induced by paraoxon and it terminated SE in a majority of animals at both time points." | 1.38 | Characterization of status epilepticus induced by two organophosphates in rats. ( Balint, CA; Cowan, ML; Kapur, J; Sun, C; Todorovic, MS, 2012) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| "Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug." | 1.36 | Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010) |
| "Of patients with status epilepticus and central nervous system infection, 24." | 1.35 | Status epilepticus in central nervous system infections: an experience from a developing country. ( Kalita, J; Misra, UK; Nair, PP, 2008) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 1.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 1.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "The current first line treatment of status epilepticus (SE) is based on the use of compounds that enhance GABAergic transmission or block sodium channels." | 1.34 | Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat. ( Mathiesen, C; Møller, A; Nissinen, J; Pitkänen, A; Rønn, LC, 2007) |
| "Levetiracetam (LEV) is a structurally novel antiepileptic drug (AED) which has demonstrated a broad spectrum of anticonvulsant activities both in experimental and clinical studies." | 1.34 | Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. ( Bethmann, K; Brandt, C; Fedrowitz, M; Gastens, AM; Glien, M; Löscher, W; Potschka, H; Volk, HA, 2007) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 1.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "Diazepam treatment alone and before cocaine overdose did not interfere with catalase activity." | 1.33 | Cocaine alters catalase activity in prefrontal cortex and striatum of mice. ( Aguiar, LM; de Sousa, FC; de Vasconcelos, SM; dos Santos, RS; Lima, VT; Macêdo, DS; Viana, GS, 2005) |
| "Diazepam was administered as the first-line drug on 157 of 177 occasions (88." | 1.33 | [Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005) |
| "We describe a case of frontal lobe epilepsy with rare nocturnal generalized tonic-clonic seizures and repeated prolonged episodes of altered behavior lasting 1 to 2 days." | 1.33 | Prefrontal disturbances as the sole manifestation of simple partial nonconvulsive status epilepticus. ( Bauer, G; Bauer, R; Benke, T; Dobesberger, J; Embacher, N; Luef, G; Trinka, E; Unterberger, I; Walser, G, 2006) |
| "We report on a 38-year-old woman with MELAS presenting with multifocal CPSE and periodic lateralized epileptiform discharges (PLEDs) on EEG during her first strokelike episode." | 1.33 | "Erratic" complex partial status epilepticus as a presenting feature of MELAS. ( Corda, D; Deiana, GA; Rosati, G; Sechi, G, 2006) |
| "Diazepam rectal gel was given more quickly and reliably, reducing total seizure time, potential neuronal injury and other complications." | 1.32 | Treatment of out-of-hospital status epilepticus with diazepam rectal gel. ( Fitzgerald, BJ; Miller, JW; Okos, AJ, 2003) |
| "In all age groups, the dosage of DZP that stopped the seizures at 5 min was not effective in terminating seizures at 60 min." | 1.32 | Diazepam terminates brief but not prolonged seizures in young, naïve rats. ( Goodkin, HP; Holmes, GL; Liu, X, 2003) |
| "Postoperative epileptic seizures are recognised but rare." | 1.31 | Postoperative pseudostatus: not everything that shakes is epilepsy. ( Enright, SM; Goulding, PJ; Reuber, M, 2000) |
| " Mean bioavailability of BDZ following IN administration was 80 +/- 9%." | 1.31 | Comparison of plasma benzodiazepine concentrations following intranasal and intravenous administration of diazepam to dogs. ( Chrisman, CL; Gronwall, RR; Hill, RC; Platt, SR; Randell, SC; Scott, KC, 2000) |
| "Non-convulsive status epilepticus is characterized by confusion and impaired consciousness, lasting at least half an hour." | 1.31 | [Non-convulsive status epilepticus--confusion and cognitive failure during seizures]. ( Engelsen, B; Karlsen, B; Lillebø, A, 2000) |
| "Status epilepticus is a condition of sustained and prolonged excitation of neuronal circuits, as detected by epileptiform discharges in the electroencephalogram (EEG)." | 1.30 | Antisense oligonucleotide to GABA(A) receptor gamma2 subunit induces limbic status epilepticus. ( Bolwig, TG; Diemer, NH; Elster, L; Karle, J; Nielsen, M; Olsen, RW; Woldbye, DP, 1998) |
| "All children who presented in a convulsion, including convulsive status epilepticus, to the accident and emergency department over a 12-month period and who required treatment, were reviewed retrospectively to identify the effectiveness and safety of a specific treatment protocol." | 1.30 | Children presenting with convulsions (including status epilepticus) to a paediatric accident and emergency department: an audit of a treatment protocol. ( Appleton, RE; Garr, RE; Molyneux, EM; Robson, WJ, 1999) |
| "Dizocilpine maleate-pretreated animals responded rapidly to diazepam treatment, even after 60 min of status epilepticus." | 1.30 | N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. ( DeLorenzo, RJ; Rice, AC, 1999) |
| "He had pseudobulbar palsy, mental retardation, and intractable epilepsy." | 1.30 | Nonconvulsive status epilepticus in a child with congenital bilateral perisylvian syndrome. ( Itagaki, Y; Kobayashi, M; Sano, T; Sumi, K; Tagawa, T, 1999) |
| "Medical records were reviewed for seizure and medication history, diagnostic test results, types of treatment, hospitalization costs, and outcome of hospital visits." | 1.30 | Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995). ( Bateman, SW; Parent, JM, 1999) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "Pretreatment with diazepam alone did reduce soman-induced seizures but did not reduce mortality of rats." | 1.29 | [Prevention and treatment of status epilepticus induced by soman]. ( Blanchet, G; Carpentier, P; Lallement, G; Sentenac-Roumanou, H, 1994) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| "In 75 occasions, the convulsion stopped within a period of 2 to 5 minutes, in 12 other times there was a need for repeated dosages and in 2 occasions, a third doses was needed." | 1.28 | [Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents]. ( Calderón González, R, 1991) |
| "Status epilepticus is a neurologic emergency with an 8% to 12% mortality." | 1.28 | Rectal diazepam in pediatric status epilepticus. ( Albano, A; Reisdorff, EJ; Wiegenstein, JG, 1989) |
| "Status epilepticus is a medical emergency." | 1.27 | Status epilepticus. ( Hall, S, 1983) |
| "Status epilepticus is a medical emergency requiring immediate treatment." | 1.27 | Treatment of status epilepticus in adults. ( Bruni, J, 1983) |
| "Status epilepticus is a medical emergency requiring immediate treatment." | 1.27 | Treatment of status epilepticus in children. ( Camfield, PR, 1983) |
| "A 55 year old man developed an acute confusional state with grossly impaired short-term memory accompanied by a Status Petit Mal epilepsy pattern on EEG, one to two weeks after abruptly discontinuing a large amount of oxazepam and a smaller amount of alcohol." | 1.27 | Acute confusional state with status petit mal as a withdrawal syndrome--and five year follow-up. ( Billings, RF; Hersch, EL, 1988) |
| "The ictal confusion in later life seems to be an entity, actually frequently reported in literature, which needs better description." | 1.27 | [A critical confusion state of frontal origin in elderly subjects: difficult diagnosis]. ( Papy, JJ; Rey, M, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 1.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "Status epilepticus is an acute, life-threatening potential complication of pregnancy in the epileptic patient." | 1.27 | Refractory status epilepticus in pregnancy. A case report. ( Field, DR; Grunert, GM, 1985) |
| "Convulsive status epilepticus is a life-threatening disorder." | 1.27 | Status epilepticus. ( Leppik, IE, 1985) |
| "Status epilepticus is a serious emergency that rarely complicates the management of the pregnant patient with seizure disorders." | 1.27 | Status epilepticus in pregnancy. A case report. ( Fougner, AC; Seltzer, VL; Wilson, SJ, 1985) |
| "Status epilepticus is a serious medical emergency requiring immediate and rational therapy." | 1.27 | Status epilepticus. ( Freeman, JM; Vining, EP, 1985) |
| "Diazepam levels were then measured at 0, 30, and 60 seconds, and at 2, 5, 15, 30, and 60 minutes." | 1.26 | Blood levels of diazepam after endotracheal administration in dogs. ( Barsan, WG; Otten, EJ; Ward, JT, 1982) |
| "Absence status is a form of generalized status epilepticus usually presenting as an acute confusional state." | 1.26 | Absence status. Case reports and a review of the literature. ( Brenner, RP; Richard, P, 1980) |
| " The status epilepticus was treated with a high dosage of diazepame." | 1.26 | [Transitory burst-suppression pattern in endogenous-exogenous encephalopathy (author's transl)]. ( Gerstenbrand, F; Hackl, JM; Rumpl, E, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (19.31) | 18.7374 |
| 1990's | 71 (18.78) | 18.2507 |
| 2000's | 95 (25.13) | 29.6817 |
| 2010's | 96 (25.40) | 24.3611 |
| 2020's | 43 (11.38) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KL | 1 |
| Abiraman, K | 1 |
| Lucaj, C | 1 |
| Ollerhead, TA | 1 |
| Brandon, NJ | 1 |
| Deeb, TZ | 1 |
| Maguire, J | 2 |
| Moss, SJ | 1 |
| Chhabra, R | 1 |
| Gupta, R | 1 |
| Gupta, LK | 1 |
| Guterman, EL | 2 |
| Burke, JF | 1 |
| Sporer, KA | 1 |
| Zhou, R | 1 |
| Wang, Y | 5 |
| Cao, X | 1 |
| Li, Z | 1 |
| Yu, J | 2 |
| West, PJ | 1 |
| Thomson, K | 1 |
| Billingsley, P | 1 |
| Pruess, T | 1 |
| Rueda, C | 1 |
| Saunders, GW | 1 |
| Smith, MD | 1 |
| Metcalf, CS | 1 |
| Wilcox, KS | 1 |
| Proietti, J | 1 |
| Fiorini, E | 1 |
| Meneghello, L | 1 |
| Cantalupo, G | 1 |
| Fontana, E | 1 |
| Lo Barco, T | 1 |
| Bernardina, BD | 1 |
| Darra, F | 1 |
| Wheless, J | 1 |
| Peters, J | 1 |
| Misra, SN | 2 |
| Becker, D | 1 |
| Rabinowicz, AL | 2 |
| Sirven, J | 1 |
| Carrazana, E | 2 |
| Cruickshank, M | 1 |
| Imamura, M | 1 |
| Counsell, C | 1 |
| Aucott, L | 1 |
| Manson, P | 1 |
| Booth, C | 1 |
| Scotland, G | 1 |
| Brazzelli, M | 1 |
| Hasan, SU | 1 |
| Pervez, A | 1 |
| Bhatty, S | 1 |
| Shamim, S | 1 |
| Naeem, A | 1 |
| Naseeb, MW | 1 |
| Zhou, X | 1 |
| Fang, L | 1 |
| Tong, X | 3 |
| Xu, Y | 1 |
| Wu, X | 3 |
| Kienitz, R | 1 |
| Kay, L | 1 |
| Beuchat, I | 1 |
| Gelhard, S | 1 |
| von Brauchitsch, S | 1 |
| Mann, C | 1 |
| Lucaciu, A | 1 |
| Schäfer, JH | 1 |
| Siebenbrodt, K | 1 |
| Zöllner, JP | 1 |
| Schubert-Bast, S | 1 |
| Rosenow, F | 2 |
| Strzelczyk, A | 2 |
| Willems, LM | 1 |
| Gidal, B | 1 |
| Detyniecki, K | 1 |
| Nakamura, K | 4 |
| Marushima, A | 2 |
| Takahashi, Y | 3 |
| Mochizuki, M | 1 |
| Kimura, A | 2 |
| Fukuda, Y | 1 |
| Asami, M | 2 |
| Nakamoto, H | 1 |
| Egawa, S | 2 |
| Kaneko, J | 3 |
| Unemoto, K | 2 |
| Kondo, Y | 2 |
| Yonekawa, C | 2 |
| Uchida, M | 1 |
| Hoshiyama, E | 2 |
| Yamada, T | 2 |
| Maruo, K | 2 |
| Ishikawa, E | 1 |
| Matsumaru, Y | 1 |
| Inoue, Y | 2 |
| Kotloski, RJ | 1 |
| Gidal, BE | 1 |
| Nuñez, P | 3 |
| Hansen, J | 3 |
| Aprea, V | 3 |
| Álvarez Ricciardi, MB | 3 |
| Oviedo, S | 3 |
| Fustiñana, A | 3 |
| Rino, P | 3 |
| Kohn Loncarica, G | 3 |
| Piantino, J | 4 |
| de Labra, C | 1 |
| Cudeiro, J | 1 |
| Rivadulla, C | 1 |
| Osman, GM | 1 |
| Hocker, SE | 1 |
| Meyer, S | 1 |
| Langer, J | 1 |
| Poryo, M | 1 |
| Bay, JG | 1 |
| Wagenpfeil, S | 1 |
| Heinrich, B | 1 |
| Nunold, H | 1 |
| Ebrahimi-Fakhari, D | 1 |
| Ramsay, RE | 4 |
| Becker, DA | 1 |
| Vazquez, B | 1 |
| Birnbaum, AK | 1 |
| Lim, KS | 1 |
| Khoo, CS | 1 |
| Fong, SL | 1 |
| Tan, HJ | 1 |
| Fong, CY | 1 |
| Mohamed, AR | 1 |
| Rashid, AA | 1 |
| Law, WC | 1 |
| Shaikh, MF | 1 |
| Khalid, RA | 1 |
| Yen-Leong Tan, R | 1 |
| Ahmad, SB | 1 |
| Chinnasami, S | 1 |
| Wong, SW | 1 |
| Raymond, AA | 1 |
| Peariso, K | 1 |
| Arya, R | 1 |
| Glauser, T | 1 |
| Abend, NS | 1 |
| Barcia Aguilar, C | 1 |
| Amengual-Gual, M | 1 |
| Anderson, A | 1 |
| Appavu, BL | 1 |
| Brenton, JN | 1 |
| Carpenter, J | 1 |
| Chapman, KE | 1 |
| Clark, J | 1 |
| Gaillard, WD | 1 |
| Gaínza-Lein, M | 1 |
| Goldstein, J | 1 |
| Goodkin, H | 1 |
| Grinspan, Z | 1 |
| Guerriero, RM | 1 |
| Horn, PS | 1 |
| Huh, L | 1 |
| Kahoud, R | 1 |
| Kelley, SA | 1 |
| Kossoff, EH | 1 |
| Kapur, K | 1 |
| Lai, YC | 1 |
| Marquis, BO | 1 |
| McDonough, T | 1 |
| Mikati, MA | 2 |
| Morgan, L | 1 |
| Novotny, E | 1 |
| Ostendorf, AP | 1 |
| Payne, ET | 1 |
| Riviello, J | 1 |
| Sands, T | 1 |
| Stafstrom, CE | 1 |
| Tasker, RC | 2 |
| Tchapyjnikov, D | 1 |
| Vasquez, A | 1 |
| Wainwright, MS | 1 |
| Wilfong, A | 1 |
| Williams, K | 1 |
| Loddenkemper, T | 2 |
| Wang, X | 1 |
| Wang, YY | 1 |
| Gao, Q | 1 |
| Zhang, YY | 1 |
| Wan, J | 1 |
| Song, CG | 1 |
| Wei, JY | 1 |
| Kang, XG | 1 |
| Yang, F | 1 |
| Jiang, W | 1 |
| Lelis, IR | 1 |
| Krauss, GL | 1 |
| Mrad, Y | 1 |
| El Jammal, R | 1 |
| Hajjar, H | 1 |
| Alturk, S | 1 |
| Salah, H | 1 |
| Chehade, HD | 1 |
| Dandash, F | 1 |
| Mallah, Z | 1 |
| Kobeissy, F | 1 |
| Habib, A | 1 |
| Hamade, E | 1 |
| Obeid, M | 1 |
| Liu, G | 2 |
| Tian, F | 2 |
| Jiang, M | 2 |
| Huang, H | 1 |
| Chen, W | 2 |
| Zhang, Y | 3 |
| Su, Y | 2 |
| Burman, RJ | 1 |
| Selfe, JS | 1 |
| Lee, JH | 1 |
| van den Berg, M | 1 |
| Calin, A | 1 |
| Codadu, NK | 1 |
| Wright, R | 1 |
| Newey, SE | 1 |
| Parrish, RR | 1 |
| Katz, AA | 1 |
| Wilmshurst, JM | 1 |
| Akerman, CJ | 1 |
| Trevelyan, AJ | 1 |
| Raimondo, JV | 1 |
| Wang, S | 3 |
| Lévesque, M | 2 |
| Avoli, M | 4 |
| Zhao, J | 1 |
| Zheng, Y | 1 |
| Liu, K | 1 |
| Chen, J | 2 |
| Lai, N | 1 |
| Fei, F | 1 |
| Shi, J | 1 |
| Xu, C | 1 |
| Nishibori, M | 1 |
| Chen, Z | 3 |
| Le Coz, J | 1 |
| Chéron, G | 1 |
| Nabbout, R | 1 |
| Patteau, G | 1 |
| Heilbronner, C | 1 |
| Hubert, P | 1 |
| Renolleau, S | 1 |
| Oualha, M | 1 |
| Yang, Y | 1 |
| Zhang, S | 1 |
| Duan, J | 1 |
| Zhang, X | 1 |
| Tang, Y | 1 |
| Rojas, A | 1 |
| Wang, J | 3 |
| Glover, A | 1 |
| Dingledine, R | 1 |
| Yu, Y | 1 |
| Li, L | 1 |
| Nguyen, DT | 1 |
| Mustafa, SM | 1 |
| Moore, BM | 1 |
| Jiang, J | 1 |
| Li, Y | 1 |
| Wu, Q | 1 |
| Shi, H | 1 |
| Chen, D | 1 |
| Zhang, C | 1 |
| Riva, A | 1 |
| Iapadre, G | 1 |
| Grasso, EA | 1 |
| Balagura, G | 1 |
| Striano, P | 1 |
| Verrotti, A | 1 |
| Shiraki, A | 1 |
| Yasui, M | 1 |
| Kidokoro, H | 1 |
| Kido, S | 1 |
| Ando, H | 1 |
| Natsume, J | 1 |
| Kamdar, HA | 1 |
| Hamed, M | 1 |
| Smetana, KS | 1 |
| Shanmugam, K | 1 |
| Peters, E | 1 |
| Yasin, R | 1 |
| Thakur, G | 1 |
| Gopal, M | 1 |
| Sawalha, K | 1 |
| Greene-Chandos, D | 1 |
| Hussein, O | 1 |
| Han, EJ | 1 |
| Chuck, CC | 1 |
| Martin, TJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Blinded, Comparative Effectiveness Study of Fosphenytoin, Valproic Acid, or Levetiracetam in the Emergency Department Treatment of Patients With Benzodiazepine-refractory Status Epilepticus.[NCT01960075] | Phase 3 | 478 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children[NCT04926844] | Phase 2 | 144 participants (Actual) | Interventional | 2021-06-20 | Completed | ||
| Non-inferiority Prospective Randomized Trial of Acetazolamide Versus Diazepam in Patients With Continuous Spike and Wave in Sleep (CSWS)/Landau Kleffner Syndrome (LKS)[NCT02904265] | Phase 2/Phase 3 | 3 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Lack of enrollment) | ||
| Use Of Lorazepam For The Treatment Of Pediatric Status Epilepticus: A Randomized, Double-Blinded Trial Of Lorazepam And Diazepam[NCT00621478] | Phase 2/Phase 3 | 259 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Electrical Status Epilepticus in Sleep: Response of Neuropsychological Deficits and Epileptiform Activity to Clobazam Treatment[NCT02127918] | 17 participants (Actual) | Observational [Patient Registry] | 2012-07-31 | Completed | |||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study of Neotrofin to Treat Patients With Sensory or Motor Neuropathy Caused by Chemotherapy for Cancer[NCT00041795] | Phase 2 | 50 participants | Interventional | 2002-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of hospital stay in days (NCT01960075)
Timeframe: length of hospital stay
| Intervention | days (Median) |
|---|---|
| Fosphenytoin (FOS) | 3 |
| Valproic Acid | 3 |
| Levetiracetam | 3 |
Length of stay is determined by the number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study. (NCT01960075)
Timeframe: number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study
| Intervention | days (Median) |
|---|---|
| Fosphenytoin (FOS) | 1 |
| Valproic Acid | 1 |
| Levetiracetam | 1 |
The time to termination of seizures is the interval from the start of study drug infusion to cessation of clinically apparent seizure in those who meet the primary outcome. (NCT01960075)
Timeframe: start of drug infusion to seizure cessation
| Intervention | minutes (Median) |
|---|---|
| Fosphenytoin (FOS) | 11.7 |
| Valproic Acid | 7.0 |
| Levetiracetam | 10.5 |
ICU admission is recorded as occurring only if the ICU is the initial inpatient unit for the patient. (NCT01960075)
Timeframe: Admission to intensive care unit after start of study drug infusion, where the ICU is the initial inpatient unit for the patient
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 70 |
| Valproic Acid | 71 |
| Levetiracetam | 87 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. The Adjudicated outcomes analysis is different from Outcome measure 1 because a central clinical phenomenology core of four neurologists adjudicated from the medical records the time to seizure cessation, the time in status epilepticus before trial-drug initiation, and the cause of the seizure. For each enrollment, two neurologists from this core group conducted independent initial reviews and then determined a consensus or consulted a third adjudicator, as needed. Adjudicators were unaware of the treatment assignments and made determinations by medical record review. (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 57 |
| Valproic Acid | 60 |
| Levetiracetam | 67 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Intention to treat (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 53 |
| Valproic Acid | 56 |
| Levetiracetam | 68 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Per-protocol analysis (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 37 |
| Valproic Acid | 43 |
| Levetiracetam | 51 |
Acute anaphylaxis is defined as a clinical presentation consistent with life threatening allergic reaction occurring within 6 hours of the start of study drug infusions and manifested as urticaria in combination with either (1) a systolic blood pressure of < 90 mmHg sustained for greater than 5 minutes, or (2) objective evidence of airway obstruction, and for which the patient was treated with antihistamines and/or steroids. (NCT01960075)
Timeframe: within 6 hours of the start of study drug infusions
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 0 |
Respiratory depression is defined as impairment of ventilation or oxygenation necessitating definitive endotracheal intubation and mechanical ventilation. It is distinct from intubations performed only for airway protection in those with decreased levels of consciousness. It does not include those getting only supraglottic airways or transient bag-valve-mask support. (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 16 |
| Valproic Acid | 10 |
| Levetiracetam | 12 |
acute seizure recurrence 60 minutes to 12 hours after start of study drug infusion (NCT01960075)
Timeframe: 60 minutes to 12 hours after start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 14 |
| Valproic Acid | 14 |
| Levetiracetam | 16 |
Safety outcome: Death (NCT01960075)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 3 |
| Valproic Acid | 2 |
| Levetiracetam | 7 |
Endotracheal intubation within 60 minutes of start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 33 |
| Valproic Acid | 21 |
| Levetiracetam | 30 |
Safety outcome: Hepatic transaminase or ammonia elevations (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 1 |
| Levetiracetam | 1 |
Life-threatening hypotension within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 4 |
| Valproic Acid | 2 |
| Levetiracetam | 1 |
Life-threatening cardiac arrhythmia within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 1 |
Purple glove syndrome is defined as the presence of all three of the findings of the objective edema: discoloration, and pain in the distal extremity in which study drug was administered, with or without known extravasation, and for which there is no other evident etiology. (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 0 |
Number of participants with seizure cessation within 20 minutes of study drug initiation for patients with treatment success. This outcome measure was only reported in the Supplementary materials to the Primary Paper. (NCT01960075)
Timeframe: within 20 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 43 |
| Valproic Acid | 43 |
| Levetiracetam | 53 |
Expect improved side effect profile of acetazolamide compared to diazepam at short-term follow up (NCT02904265)
Timeframe: 4-8 weeks of start of medications
| Intervention | Participants (Count of Participants) |
|---|---|
| Diazepam | 1 |
| Acetazolamide | 2 |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
51 reviews available for diazepam and Absence Status
| Article | Year |
|---|---|
Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis.
Topics: Administration, Intranasal; Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Midazolam; Pr | 2021 |
Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Seizures; Status Epilepticus | 2022 |
Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.
Topics: Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Lorazepam; Midazolam; Network Meta-Analys | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy, | 2022 |
Rescue Treatments for Seizure Clusters.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Midazolam; Nasal S | 2022 |
Acute Abortive Therapies for Seizure Clusters in Long-Term Care.
Topics: Aged; Anticonvulsants; Diazepam; Epilepsy; Humans; Long-Term Care; Status Epilepticus; United States | 2023 |
Intramuscular Midazolam for treatment of Status Epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Injections, Intramuscular; Midazolam; Status Epilepticus | 2021 |
Rescue therapies for seizure emergencies: current and future landscape.
Topics: Anticonvulsants; Child; Diazepam; Emergencies; Humans; Seizures; Status Epilepticus | 2021 |
A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Humans; Nasal Sprays; Quality of Life; Seizur | 2021 |
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.
Topics: Administration, Inhalation; Administration, Oral; Administration, Rectal; Anticonvulsants; Child; Di | 2018 |
Complex febrile seizures: a practical guide to evaluation and treatment.
Topics: Algorithms; Anticonvulsants; Critical Pathways; Cross-Sectional Studies; Diazepam; Emergency Service | 2013 |
Neuroactive steroids for the treatment of status epilepticus.
Topics: Anesthetics; Animals; Benzodiazepines; Diazepam; Humans; Neurotransmitter Agents; Pregnanolone; Stat | 2013 |
[Treatment of status epilepticus].
Topics: Anesthesia, General; Diazepam; Drug Administration Routes; Evidence-Based Medicine; Humans; Hypother | 2014 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Injections, Intravenous; Lorazepam; Midazolam; Phenobarbital; Phe | 2014 |
Nonintravenous midazolam versus intravenous or rectal diazepam for the treatment of early status epilepticus: A systematic review with meta-analysis.
Topics: Administration, Intravenous; Administration, Rectal; Anticonvulsants; Diazepam; Humans; Midazolam; R | 2015 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Recent advances in status epilepticus.
Topics: Amides; Anticonvulsants; Diazepam; Humans; Midazolam; Seizures; Status Epilepticus | 2016 |
A Comparison of Midazolam, Lorazepam, and Diazepam for the Treatment of Status Epilepticus in Children: A Network Meta-analysis.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Infant; Lorazepam; Mi | 2016 |
Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Seizures; Status Epilepticus; Treatment Outcome | 2016 |
Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Anticonvulsants; Diazepam; Humans; Lorazepam; Randomized Controlled Tri | 2016 |
Treatment of status epilepticus in children.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Drug Therapy, Comb | 2004 |
Why is the developing brain more susceptible to status epilepticus?
Topics: Animals; Animals, Newborn; Brain; Diazepam; Disease Models, Animal; Female; Humans; Male; Pentobarbi | 2009 |
Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis.
Topics: Adolescent; Anticonvulsants; Child; Diazepam; Humans; Midazolam; Status Epilepticus; Treatment Outco | 2010 |
Benzodiazepines for prolonged seizures.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Humans; Infant; Lorazepam; Midazolam; | 2010 |
A systematic review of randomized controlled trials on the theraputic effect of intravenous sodium valproate in status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Injections, Intravenous; Levetiracetam; Phenytoin; Piracetam; Ran | 2012 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Ma | 2001 |
Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Epilepsy, Tonic-Clonic; Humans; Injections | 2002 |
[Evidence-based treatment for status epilepticus in childhood--working up guidelines for its treatment].
Topics: Adolescent; Animals; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Evidence-Base | 2005 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Phenobarbital; Phenytoin; Randomized Contro | 2005 |
[Update on current care guidelines. Prolonged epileptic attack].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; El | 2006 |
Best evidence topic reports. Lorazepam or diazepam in paediatric status epilepticus.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Evidence-Based Medicine; Female; Humans; Infusions, Int | 2006 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Phenobarbital; Phenytoin; Randomized Contro | 2007 |
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
Constant diazepam infusion in the treatment of continuous seizure activity.
Topics: Diazepam; Drug Stability; Emergencies; Humans; Infant; Infant, Newborn; Infusions, Parenteral; Prosp | 1984 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Therapy for status epilepticus.
Topics: Acetazolamide; Anesthesia; Anticonvulsants; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Eth | 1983 |
Status epilepticus: mechanisms of brain damage and rational management.
Topics: Anticonvulsants; Brain Damage, Chronic; Diazepam; Electroencephalography; Humans; Phenytoin; Status | 1982 |
Treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Diazepam; Humans; Phenobarbital; Phenytoin; Status | 1993 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Rational polytherapy in the treatment of status epilepticus.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Diazepam; Drug Interactions; Drug Synergism; Drug Ther | 1996 |
Emergency treatment of acute seizures and status epilepticus.
Topics: Acute Disease; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergencies; Glucose; Humans; Inf | 1998 |
Seizure management in pediatric patients for the nineties.
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; F | 1998 |
Acute cellular alterations in the hippocampus after status epilepticus.
Topics: Animals; Barbiturates; Benzodiazepines; Cerebellar Nuclei; Diazepam; Disease Models, Animal; Drug To | 1999 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Isoflurane; | 1999 |
Drug therapy reviews: drug therapy of status epilepticus.
Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil | 1978 |
The pharmacokinetics of agents used to treat status epilepticus.
Topics: Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Lipi | 1990 |
Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus.
Topics: Benzodiazepines; Chemical Phenomena; Chemistry; Clonazepam; Diazepam; Humans; Lorazepam; Status Epil | 1989 |
Status epilepticus in children and adults.
Topics: Adult; Anticonvulsants; Child; Diazepam; Drug Therapy, Combination; Humans; Infusions, Intravenous; | 1988 |
[Status epilepticus in childhood].
Topics: Brain; Child; Child, Preschool; Diazepam; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn | 1986 |
30 trials available for diazepam and Absence Status
| Article | Year |
|---|---|
Clinical efficacy of clonazepam in the treatment of status epilepticus.
Topics: Anticonvulsants; Clonazepam; Diazepam; Humans; Quality of Life; Status Epilepticus; Treatment Outcom | 2022 |
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Levetiracetam; Phenytoin; Seizures; Status Epilepticus; Tr | 2023 |
Development and validation of a nomogram to provide individualized predictions of functional outcomes in patients with convulsive status epilepticus at 3 months: The modified END-IT tool.
Topics: Diazepam; Encephalitis; Humans; Nomograms; Prognosis; Status Epilepticus | 2023 |
Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial.
Topics: Adult; Anticonvulsants; Diazepam; Follow-Up Studies; Humans; Phenobarbital; Status Epilepticus; Trea | 2023 |
Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.
Topics: Adolescent; Adult; Age Factors; Benzodiazepines; Child; Diazepam; Dose-Response Relationship, Drug; | 2021 |
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for status epilepticus: study protocol for a multicenter non-inferiority designed randomized control trial.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Japan; Levetiracetam; Multicenter Studies as Topic; Neopla | 2021 |
A Phase 3 open-label study of the efficacy, safety and pharmacokinetics of buccally administered midazolam hydrochloride for the treatment of status epilepticus in pediatric Japanese subjects.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Japan; Midazolam; Status Epilepticus | 2021 |
Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial.
Topics: Administration, Intranasal; Administration, Rectal; Animals; Anticonvulsants; Diazepam; Dog Diseases | 2017 |
Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus.
Topics: Administration, Intravenous; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Dose-Re | 2018 |
Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures.
Topics: Administration, Intravenous; Administration, Rectal; Animals; Anticonvulsants; Diazepam; Dog Disease | 2019 |
Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Huma | 2015 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male | 2016 |
Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus.
Topics: Adolescent; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; Data Interpretation, Statistica | 2017 |
Intravenous sodium valproate in mainland China for the treatment of diazepam refractory convulsive status epilepticus.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; China; Diazepam; Female; Humans; | 2009 |
Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial.
Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Electroen | 2010 |
Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus.
Topics: Administration, Buccal; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; | 2011 |
Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Cerebrovascular Disorders; Diazepam; Drug Resistance; Electroencephalo | 2011 |
Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Dose-Response Relationship, Drug; El | 2002 |
Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children.
Topics: Administration, Intranasal; Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; D | 2004 |
Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Hypotension; Infant; Infusions, | 2007 |
Double-blind study of lorazepam and diazepam in status epilepticus.
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Humans; Infusi | 1983 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Topics: Aged; Anticonvulsants; Diazepam; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inj | 1998 |
Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus.
Topics: Adult; Anticonvulsants; Diazepam; Double-Blind Method; Emergency Medical Services; Emergency Medical | 2001 |
Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female; Humans; In | 2002 |
Comparative audit of intravenous lorazepam and diazepam in the emergency treatment of convulsive status epilepticus in children.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Medical Services; Female; Humans; Infa | 2002 |
[Treatment of status epilepticus with clonazepam].
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Diazepam; Drug Evaluation; Humans; Phenobar | 1976 |
Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Female; Humans; Male; Mi | 1988 |
Non-convulsive status epilepticus resistant to benzodiazepines.
Topics: Adolescent; Benzodiazepines; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Diazepam | 1987 |
297 other studies available for diazepam and Absence Status
| Article | Year |
|---|---|
Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.
Topics: Animals; Diazepam; Epilepsy; Hippocampus; Humans; Lysine; Mice; Mice, Inbred C57BL; Rats; Status Epi | 2022 |
Prehospital Treatment of Status Epilepticus in the United States.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Emergency Medical Services; Guideline Adherence; Humans; | 2021 |
Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model.
Topics: Analgesics; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Administration Schedule | 2021 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; | 2022 |
Non-convulsive febrile status epilepticus mimicking a postictal state after a febrile seizure: an ictal electroclinical and evolutive study.
Topics: Child; Cyanosis; Diazepam; Electroencephalography; Fever; Humans; Infant; Seizures, Febrile; Status | 2022 |
Comment on "Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis".
Topics: Administration, Intranasal; Benzodiazepines; Child; Diazepam; Humans; Seizures; Status Epilepticus | 2022 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Management of status epilepticus in childhood: a survey conducted at pediatric hospitals in the City of Buenos Aires.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Diazepam; Hospitals, Pediatric; Humans; Status Epil | 2023 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Status Epilepticus in Older Adults: Diagnostic and Treatment Considerations.
Topics: Aged; Anticonvulsants; Benzodiazepines; Diazepam; Humans; Midazolam; Status Epilepticus | 2023 |
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two-year prospective surveillance study.
Topics: Adolescent; Anticonvulsants; Child; Critical Care; Diazepam; Epilepsy; Female; Humans; Male; Midazol | 2023 |
Management of status epilepticus in Malaysia: A national survey of current practice and treatment gap.
Topics: Anticonvulsants; Diazepam; Humans; Malaysia; Midazolam; Status Epilepticus | 2023 |
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children.
Topics: Anticonvulsants; Benzodiazepines; Case-Control Studies; Child; Diazepam; Drug Resistant Epilepsy; Hu | 2023 |
Sublingual lorazepam as rescue therapy for seizure emergencies in adults.
Topics: Adult; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Lorazepam; Retrospective Studies; S | 2023 |
Lestaurtinib (CEP-701) reduces the duration of limbic status epilepticus in periadolescent rats.
Topics: Animals; Brain Injuries; Child; Diazepam; Furans; Hippocampus; Humans; Rats; Status Epilepticus | 2023 |
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Drug Resistance; Drug Resista | 2019 |
Effects of Diazepam and Ketamine on Pilocarpine-Induced Status Epilepticus in Mice.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Hippocampus; Ketamine; Mice; Pilocarpine | 2019 |
HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window.
Topics: Animals; Antibodies, Monoclonal; Anticonvulsants; Biomarkers; Diazepam; Drug Resistant Epilepsy; HMG | 2020 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
Acute visual impairment as a main presenting symptom of non-convulsive status epilepticus: a case report.
Topics: Anticonvulsants; Cognitive Dysfunction; Dementia, Vascular; Diazepam; Diffusion Magnetic Resonance I | 2020 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Cytokines; Diazepam; Disease Models, Animal; Drug | 2020 |
Generalized convulsive status epilepticus after retrograde type A aortic dissection surgery.
Topics: Anticonvulsants; Aortic Dissection; Diazepam; Humans; Midazolam; Status Epilepticus | 2021 |
Initial treatment of seizures in children in an emergency department in rural Japan.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Diazepam; Emergency Medical S | 2021 |
Lorazepam timing for acute convulsive seizure control (LoTASC).
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Benzodiazepines; Diazepam; Female; Humans; Lorazepam; M | 2020 |
Statewide Emergency Medical Services Protocols for Status Epilepticus Management.
Topics: Administration, Intranasal; Administration, Rectal; Adult; Anticonvulsants; Benzodiazepines; Child; | 2021 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
A comparison of intravenous midazolam and diazepam in management of status epilepticus in children.
Topics: Anticonvulsants; Child; Diazepam; Humans; Midazolam; Pakistan; Status Epilepticus | 2021 |
Blood concentration of levetiracetam after bolus administration in patients with status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Levetiracetam; Piracetam; Seizures; Status Epilepticus | 2021 |
Intramuscular Lorazepam for Status Epilepticus in Children With Complex Medical and Physical Disabilities.
Topics: Administration, Rectal; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Dose- | 2017 |
Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices.
Topics: Animals; Anticonvulsants; Atropine; Corticosterone; Diazepam; Disease Models, Animal; Electric Stimu | 2017 |
Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2017 |
The neuroprotective effect of perampanel in lithium-pilocarpine rat seizure model.
Topics: Animals; Anticonvulsants; Antigens, Nuclear; Brain; Cell Death; Diazepam; Dose-Response Relationship | 2017 |
Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.
Topics: Administration, Intravenous; Administration, Oral; Anticonvulsants; Blood Pressure; Databases, Factu | 2017 |
Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Glucuronosyltransferase; Heme Oxygenase-1; Hippocampus; Kainic A | 2018 |
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Topics: Animals; Brain; Brain Waves; Carbamates; Cognition Disorders; Diazepam; Disease Models, Animal; Dose | 2018 |
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.
Topics: Animals; Anticonvulsants; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Child; Cyclopentan | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Diazepam for outpatient treatment of nonconvulsive status epilepticus in pediatric patients with Angelman syndrome.
Topics: Ambulatory Care; Ambulatory Care Facilities; Angelman Syndrome; Anticonvulsants; Child; Child, Presc | 2018 |
Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.
Topics: Animals; Antidotes; Brain; Diazepam; Disease Models, Animal; Humans; Interneurons; Male; Nerve Agent | 2018 |
50 Years Ago in The Journal of Pediatrics: The Treatment of Prolonged Seizure Activity with Intravenous Diazepam.
Topics: Anticonvulsants; Diazepam; History, 20th Century; Humans; Injections, Intravenous; Pediatrics; Perio | 2018 |
Efficacy, safety, and pharmacokinetics of intravenous midazolam in Japanese children with status epilepticus.
Topics: Administration, Intravenous; Adolescent; Anesthetics, Intravenous; Anticonvulsants; Child; Child, Pr | 2019 |
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
Topics: Administration, Intravenous; Anesthetics; Animals; Anticonvulsants; Diazepam; Drug Resistant Epileps | 2019 |
Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats.
Topics: Animals; Anticonvulsants; Dapsone; Diazepam; Electroencephalography; Hippocampus; Kainic Acid; Male; | 2019 |
A hospital-based study on caregiver preferences on acute seizure rescue medications in pediatric patients with epilepsy: Intranasal midazolam versus rectal diazepam.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Anticonvulsants; Caregivers; Child; | 2019 |
Emergency Medical Services Protocols for Generalized Convulsive Status Epilepticus.
Topics: Administration, Intravenous; Anticonvulsants; California; Clinical Protocols; Diazepam; Emergency Me | 2019 |
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe | 2019 |
Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium.
Topics: Administration, Intranasal; Administration, Oral; Administration, Rectal; Adolescent; Age Factors; A | 2019 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Death; Diazepam; Disease Models, Animal; Drug Therapy, Combination; | 2013 |
Prolonged febrile seizures, clinical characteristics, and acute management.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Emergency Medical Services; Emergency Service, Hospital | 2013 |
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop | 2013 |
Hyponatremia augments kainic-acid induced status epilepticus in the mouse: a model for dysmetabolic status epilepticus.
Topics: Animals; Anticonvulsants; Blood Glucose; Data Interpretation, Statistical; Diazepam; Electrodes, Imp | 2013 |
Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Deep Brain Stimulation; Diazepam; Diseas | 2013 |
Medical management with diazepam for electrical status epilepticus during slow wave sleep in children.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Brain; Caregivers; Child; Child, Preschool; Diaze | 2014 |
Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.
Topics: Animals; Anticonvulsants; Atropine; Brain; Calcium; Diazepam; Disease Models, Animal; Electroencepha | 2014 |
[Case of an elderly woman with dementia showing episodic involuntary movement of the tongue].
Topics: Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Diagnosis, Differential; Diazepam; Drug Thera | 2014 |
[Cost-effectiveness of buccal midazolam in the treatment of prolonged convulsive seizures in the outpatient setting in Spain].
Topics: Administration, Oral; Administration, Rectal; Adolescent; Ambulatory Care; Anticonvulsants; Child; C | 2014 |
Quality assurance evaluation of a simple linear protocol for the treatment of impending status epilepticus in a pediatric emergency department 2 years postimplementation.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Protocols; Diazepam; Emergency Servic | 2014 |
[Nonconvulsive status epilepticus as an initial symptom in a boy with frontal lobe epilepsy].
Topics: Anticonvulsants; Child; Diazepam; Electroencephalography; Epilepsy, Frontal Lobe; Humans; Male; Stat | 2014 |
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio | 2014 |
Treatments for pediatric status epilepticus.
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Status Epilepticus | 2014 |
Treatments for pediatric status epilepticus--reply.
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Status Epilepticus | 2014 |
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study.
Topics: Administration, Intranasal; Administration, Intravenous; Aged; Aged, 80 and over; Anticonvulsants; D | 2015 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice.
Topics: Animals; Anticonvulsants; Brain Waves; Bridged-Ring Compounds; Central Nervous System; Diazepam; Dis | 2015 |
Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure.
Topics: alpha-Linolenic Acid; Animals; Antigens, Nuclear; Atropine Derivatives; Avoidance Learning; Brain Da | 2015 |
Intravenous levetiracetam treatment in status epilepticus: A prospective study.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Diazepam; | 2015 |
Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Aspergillus oryzae; Benzodiazepines; Diazepam; | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Lorazepam v. diazepam for pediatric status epilepticus.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Humans; Infant; Lorazepam; Male; Randomized Con | 2016 |
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, I | 2015 |
Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2015 |
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Diazepam; Disease Models, Animal; Enzym | 2015 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
Making SENSE--Sustained Effort Network for treatment of Status Epilepticus as a multicenter prospective registry.
Topics: Adult; Aged; Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Midazolam; Middle Aged; Phe | 2015 |
Extracellular levels of ATP and acetylcholine during lithium-pilocarpine induced status epilepticus in rats.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anticonvulsants; Diazepam; Extracellular Space; Hipp | 2016 |
Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Bumetanide; Diazepam; Disease Progression; Drug Resistant Epilepsy; | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Hippocampus; In | 2016 |
Intranasal midazolam for seizure cessation in the community setting.
Topics: Administration, Intranasal; Ambulatory Care Facilities; Anticonvulsants; Child; Diazepam; Humans; Mi | 2016 |
Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis.
Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Anticonvulsants; Autoantibodies; Benzodiazepines; C | 2017 |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Count; Diazepam; Disease Models, Animal; Electric | 2017 |
Status epilepticus in central nervous system infections: an experience from a developing country.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Central Nervous System Infections; Developing Countries; D | 2008 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Cell Death; Ceramides; Diazepam; Di | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Audit of treatment of convulsive status epilepticus.
Topics: Anticonvulsants; Child; Diazepam; Humans; Midazolam; Paraldehyde; Phenobarbital; Phenytoin; Practice | 2008 |
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Brain; Cholinesterase Inhibitors; Diaze | 2009 |
A simple quantitative method for analyzing electrographic status epilepticus in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; | 2009 |
Treatment of community-onset childhood convulsive status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Injections, Intravenous; Lorazepam | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Carbamazepine; Dentate Gyrus; Diazepam; Drug Administration Schedule; Glia | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide.
Topics: Acetamides; Adult; Anticonvulsants; Diazepam; Drug Resistance; Drug Therapy, Combination; Epilepsy; | 2010 |
The impact of diazepam's discovery on the treatment and understanding of status epilepticus.
Topics: Animals; Benzodiazepines; Diazepam; Drug Resistance; Endocytosis; Hippocampus; History, 20th Century | 2009 |
Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood Pressure; Diazepam; Disease Model | 2010 |
A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations.
Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Benzodiazepines; Diazepam; Drug A | 2010 |
[Use of injectable lorazepam in status epilepticus: a comparative study in French-speaking hospitals].
Topics: Anticonvulsants; Belgium; Canada; Diazepam; Drug Utilization; France; Guidelines as Topic; Health Ca | 2010 |
The control of kainic acid-induced status epilepticus.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2010 |
Convulsive status epilepticus in children: etiology, treatment protocol and outcome.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Encephalitis; Female; Humans; Infant; Male; Meni | 2011 |
Effect of mild hypothermia on glutamate receptor expression after status epilepticus.
Topics: Animals; Apoptosis; Blotting, Western; Cell Count; Diazepam; Electrodes, Implanted; Electroencephalo | 2012 |
Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep.
Topics: Adolescent; Anticonvulsants; Brain Waves; Child; Child, Preschool; Diazepam; Dose-Response Relations | 2012 |
Characterization of status epilepticus induced by two organophosphates in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Electroencephalography; Isoflurophate; Male; Ne | 2012 |
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohist | 2012 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.
Topics: Amides; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Elect | 2013 |
Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus.
Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Calcium Signaling; Cell Membrane; Dia | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
Treatment of out-of-hospital status epilepticus with diazepam rectal gel.
Topics: Administration, Rectal; Adult; Anticonvulsants; Assisted Living Facilities; Diazepam; Emergency Medi | 2003 |
Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid.
Topics: Animals; Chromatography, Liquid; Diazepam; Male; Mass Spectrometry; Molecular Structure; Rats; Rats, | 2003 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
[Status epilepticus].
Topics: Adult; Anticonvulsants; Diazepam; Humans; Phenytoin; Status Epilepticus | 2003 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
Diazepam terminates brief but not prolonged seizures in young, naïve rats.
Topics: Age Factors; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; | 2003 |
TREATMENT OF STATUS EPILEPTICUS WITH DIAZEPAM (VALIUM).
Topics: Adolescent; Barbiturates; Child; Diazepam; Drug Therapy; Electrocardiography; Electroencephalography | 1965 |
Creutzfeldt-Jakob disease and non-convulsive status epilepticus: a clinical and electroencephalographic follow-up study.
Topics: Aged; Anticonvulsants; Creutzfeldt-Jakob Syndrome; Diazepam; Electroencephalography; Female; Follow- | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Effects of fosphenytoin on nerve agent-induced status epilepticus.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose- | 2004 |
Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus.
Topics: Action Potentials; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Therap | 2004 |
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Chi-Square Distribution; Di | 2005 |
Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Cyclohexanes; Cyclohexenes; Diazepam; Diffusion Magneti | 2005 |
Cocaine alters catalase activity in prefrontal cortex and striatum of mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Bupropion; Catalase; Catecholamines; Cocaine | 2005 |
[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female | 2005 |
[Management of status epilepticus].
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Diazepam; Dr | 2005 |
Prefrontal disturbances as the sole manifestation of simple partial nonconvulsive status epilepticus.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy, Frontal Lobe; Female; Humans; Injection | 2006 |
Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Dose-Response Relationship, Drug; Electroencephalograp | 2006 |
Nonconvulsive status epilepticus due to ifosfamide.
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Diazepam; Female; Humans; Ifosfamide; Levetirace | 2006 |
When benzodiazepines fail: how effective is second line therapy for status epilepticus in children?
Topics: Anesthetics; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Diazepam; Dose-Response Rela | 2006 |
"Erratic" complex partial status epilepticus as a presenting feature of MELAS.
Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Electroencephalography; Female; Humans; MELAS Syndr | 2006 |
Transient occipitotemporal subcortical diffusion-weighted magnetic resonance imaging abnormalities associated with status epilepticus. Case report.
Topics: Adult; Carbamazepine; Diazepam; Diffusion Magnetic Resonance Imaging; Drug Administration Schedule; | 2006 |
Anticonvulsant properties of hypothermia in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Cold Temperature; Dentate Gyrus; Diazepam; Diseas | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph | 2006 |
Community use of intranasal midazolam for managing prolonged seizures.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Aged; Anticonvulsants; Attitu | 2006 |
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fructo | 2007 |
Lithium-methomyl induced seizures in rats: a new model of status epilepticus?
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Synergism; Electroencephalography; | 2007 |
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Early diffusion-weighted MRI predicts regional neuronal damage in generalized status epilepticus in rats treated with diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Damage, Chronic; Convulsants; Diazepam; Diffusion; Diffusion | 2007 |
Treatment of late lithium-pilocarpine-induced status epilepticus with diazepam.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Electroencephalography; Lithium C | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Brain Damage, Chronic; D | 2007 |
Headache as a sole manifestation in nonconvulsive status epilepticus.
Topics: Anticonvulsants; Child; Diazepam; Electroencephalography; Headache; Humans; Male; Status Epilepticus | 2007 |
A case with atypical childhood occipital epilepsy "Gastaut type": an ictal migraine manifestation with a good response to intravenous diazepam.
Topics: Adolescent; Anticonvulsants; Comorbidity; Diazepam; Electroencephalography; Epilepsies, Partial; Epi | 2007 |
First-line therapy for theophylline-associated seizures.
Topics: Age of Onset; Animals; Anticonvulsants; Barbiturates; Brain Damage, Chronic; Child; Child, Preschool | 2007 |
[A successful single nocturnal use of diazepam to treat non-convulsive status epilepticus].
Topics: Angelman Syndrome; Anticonvulsants; Circadian Rhythm; Diazepam; Drug Administration Schedule; Electr | 2007 |
Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Diazepam; Disease Models, Animal; D | 2007 |
A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation.
Topics: Animals; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2008 |
Significance of atypical triphasic waves for diagnosing nonconvulsive status epilepticus.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Brain Diseases, Metabolic; Diazepam; Electroencephalograph | 2007 |
Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; | 2008 |
Effective treatments of prolonged status epilepticus in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, | 2008 |
Re: New lessons: classic treatments in convulsive status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Phenytoin; Status Epilepticus; Valpro | 2008 |
From drugs to delirium.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Male; Psychomotor Performance; Status Epilepticus; Substan | 2008 |
A monkey model for status epilepticus: carbamazepine and valproate compared to three standard anticonvulsants.
Topics: Aluminum Hydroxide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Macaca mulatta; Male; Phenoba | 1983 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
[New effective therapeutic form of status epilepticus using undiluted long-term infusion of diazepam].
Topics: Adolescent; Adult; Diazepam; Humans; Infusions, Parenteral; Middle Aged; Status Epilepticus | 1984 |
Status epilepticus.
Topics: Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1983 |
DIAS rounds. Diazepam infusions.
Topics: Diazepam; Humans; Infusions, Parenteral; Status Epilepticus | 1984 |
Status epilepticus.
Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial; | 1980 |
High-performance liquid chromatographic and gas-liquid chromatographic determination of diazepam and nordiazepam in plasma.
Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Diazepam; Humans; Male; Nordazepam | 1980 |
[Termination of status epilepticus with sodium valproate].
Topics: Clonazepam; Diazepam; Humans; Infant; Phenytoin; Status Epilepticus; Valproic Acid | 1980 |
Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Chlormethiazole; Clona | 1981 |
Therapy of status epilepticus.
Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy | 1982 |
Treatment of status epilepticus in adults.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Critical Care; Diazepam; Electrocardiography; Electroenc | 1983 |
Treatment of status epilepticus in children.
Topics: Anticonvulsants; Barbiturates; Child, Preschool; Diazepam; Emergencies; Humans; Infant; Infant, Newb | 1983 |
General principles of treatment: status epilepticus in neonates.
Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital | 1983 |
Efficacy of phenytoin in treatment of status epilepticus.
Topics: Brain; Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1983 |
Benzodiazepines: efficacy in status epilepticus.
Topics: Adult; Aged; Benzodiazepines; Child; Clonazepam; Diazepam; Electroencephalography; Humans; Status Ep | 1983 |
Combination therapy for status epilepticus: intravenous diazepam and phenytoin.
Topics: Diazepam; Drug Therapy, Combination; Electroencephalography; Humans; Infusions, Parenteral; Injectio | 1983 |
Identification and treatment of status epilepticus.
Topics: Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1980 |
Current concepts in neurology: management of status epilepticus.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Humans; Lorazepam; Phenobarbital; Phenytoin | 1982 |
Blood levels of diazepam after endotracheal administration in dogs.
Topics: Animals; Blood Gas Analysis; Diazepam; Dogs; Intubation, Intratracheal; Kinetics; Pilot Projects; St | 1982 |
Management of status epilepticus.
Topics: Diazepam; Humans; Lorazepam; Oxygen Inhalation Therapy; Status Epilepticus | 1982 |
Current treatment of status epilepticus.
Topics: Adult; Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Humans; Hysteria; Injections, Intr | 1981 |
Rectal diazepam in the treatment of absence status: a pharmacodynamic study.
Topics: Adult; Diazepam; Humans; Male; Rectum; Solutions; Status Epilepticus; Suppositories; Time Factors | 1981 |
Intravenous clonazepam in the treatment of status epilepticus in children.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Diazepam; Electroencephalography | 1980 |
Therapy for status epilepticus.
Topics: Diazepam; Drug Therapy, Combination; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1980 |
Absence status. Case reports and a review of the literature.
Topics: Adult; Aged; Diagnosis, Differential; Diazepam; Electroencephalography; Female; Humans; Male; Middle | 1980 |
Non-convulsive status epilepticus.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Diazepam; Electroencephalography; Fem | 1995 |
Effect of prehospital treatment on the outcome of status epilepticus in children.
Topics: Administration, Rectal; Adolescent; Allied Health Personnel; Child; Child, Preschool; Diazepam; Dose | 1995 |
Catatonia mimicking nonconvulsive status epilepticus.
Topics: Adult; Benzodiazepines; Bipolar Disorder; Catatonia; Diagnosis, Differential; Diazepam; Electroencep | 1995 |
Benzyl alcohol poisoning following diazepam intravenous infusion.
Topics: Benzoates; Benzoic Acid; Benzyl Alcohol; Benzyl Alcohols; Child, Preschool; Diazepam; Female; Humans | 1995 |
The intensive care treatment of convulsive status epilepticus in the UK. Results of a national survey and recommendations.
Topics: Anesthetics, General; Anticonvulsants; Clinical Protocols; Critical Care; Diazepam; Drug Resistance; | 1995 |
Defusing status epilepticus.
Topics: Blood Gas Analysis; Body Temperature; Diazepam; Humans; Infusions, Intravenous; Lung Diseases, Obstr | 1995 |
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr | 1995 |
Cardiac hypertrophy secondary to status epilepticus in the rat.
Topics: Animals; Body Weight; Cardiomegaly; Diazepam; Dizocilpine Maleate; Electroencephalography; Lithium C | 1995 |
Diazepam or lorazepam for prolonged seizures?
Topics: Brain; Diazepam; Electroconvulsive Therapy; Electroencephalography; Emergencies; Humans; Infusions, | 1994 |
Non-convulsive status epilepticus in the adult mentally retarded. Classification and role of benzodiazepines.
Topics: Adult; Aged; Anti-Anxiety Agents; Brain Damage, Chronic; Cerebral Cortex; Diazepam; Drug Therapy, Co | 1993 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroenc | 1994 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
[Prevention and treatment of status epilepticus induced by soman].
Topics: Animals; Diazepam; Guinea Pigs; Male; Phencyclidine; Rats; Rats, Wistar; Soman; Status Epilepticus | 1994 |
The need for guidelines on the use of rectal diazepam.
Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; First Aid; Humans; | 1993 |
Failure to recognize status epilepticus in a paralysed patient.
Topics: Adolescent; Diazepam; Electroencephalography; Female; Humans; Neuromuscular Blocking Agents; Nitraze | 1993 |
Rectal diazepam for prehospital pediatric status epilepticus.
Topics: Administration, Rectal; Adolescent; Child; Child, Preschool; Diazepam; Emergencies; Female; Humans; | 1994 |
Development of a piglet model of status epilepticus: preliminary results.
Topics: Animals; Bicuculline; Diazepam; Hemodynamics; Lorazepam; Models, Biological; Pilot Projects; Respira | 1993 |
Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Hypersensitivity; Female; Hospitals, Pediatric; Ho | 1993 |
Pharmacological dissociation of the motor and electrical aspects of convulsive status epilepticus induced by the cholinesterase inhibitor soman.
Topics: Analysis of Variance; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Elec | 1993 |
ECT-induced status.
Topics: Adult; Diazepam; Electroconvulsive Therapy; Electroencephalography; Female; Humans; Lithium; Status | 1993 |
MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.
Topics: Animals; Atropine; Diazepam; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Limbic Sys | 1993 |
Complex partial status epilepticus in childhood.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Electroencephalograph | 1995 |
Long-duration self-sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Hippocampus; In | 1995 |
Nonconvulsive status epilepticus in the emergency room.
Topics: Adult; Aged; Anticonvulsants; Confusion; Diagnosis, Differential; Diazepam; Drug Therapy, Combinatio | 1996 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; | 1996 |
High-performance liquid chromatographic determination of midazolam in rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Disea | 1996 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
Treatment of focal status epilepticus with lignocaine.
Topics: Aged; Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Generalized; Humans; Lidocaine; Male | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Status epilepticus in children: aetiology, treatment, and outcome.
Topics: Adolescent; Age Distribution; Anesthetics, Intravenous; Anticonvulsants; Barbiturates; Chi-Square Di | 1997 |
Refractory status epilepticus in children: role of continuous diazepam infusion.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, Intravenous; | 1998 |
Comparison of single- and repeated-dose pharmacokinetics of diazepam.
Topics: Animals; Chromatography, High Pressure Liquid; Clinical Protocols; Diazepam; Dose-Response Relations | 1998 |
[De novo absence status: case report].
Topics: Diabetes Complications; Diazepam; Electroencephalography; Female; Follow-Up Studies; Humans; Middle | 1997 |
Generalized tonic-clonic status epilepticus: causes, treatment, complications and predictors of case fatality.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Demography; Diazepam; Epilepsy, Tonic-Clonic; Femal | 1998 |
Time-dependent decrease in the effectiveness of antiepileptic drugs during the course of self-sustaining status epilepticus.
Topics: Animals; Anticonvulsants; Diazepam; Drug Evaluation, Preclinical; Male; Phenytoin; Rats; Rats, Wista | 1998 |
[Interpreting symptoms correctly. Who does one recognize a grand mal seizure? 3: Diagnosis and therapy of epileptic seizures].
Topics: Anticonvulsants; Diazepam; Drug Therapy, Combination; Emergencies; Epilepsy, Tonic-Clonic; Humans; S | 1998 |
Antisense oligonucleotide to GABA(A) receptor gamma2 subunit induces limbic status epilepticus.
Topics: Animals; Anticonvulsants; Diazepam; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Male; | 1998 |
Treatment of acute repetitive seizures.
Topics: Administration, Rectal; Adult; Child; Clinical Trials as Topic; Diazepam; Epilepsy; Ethics, Medical; | 1998 |
Hanging-induced status epilepticus.
Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Electroencephalography; Emergency Treat | 1999 |
Initial treatment of generalized convulsive status epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Diazepam; Double-Blind Method; Electroencephalography; Emergenci | 1999 |
Buccal route for benzodiazepines in treatment of seizures?
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
Children presenting with convulsions (including status epilepticus) to a paediatric accident and emergency department: an audit of a treatment protocol.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 1999 |
Camphor toxicity.
Topics: Anticonvulsants; Antidotes; Camphor; Charcoal; Consumer Product Safety; Diazepam; Female; Humans; In | 1999 |
N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dizocilpine Maleate; Drug Resistance; Electroencephalography; Ex | 1999 |
Nonconvulsive status epilepticus in a child with congenital bilateral perisylvian syndrome.
Topics: Anticonvulsants; Brain; Cerebral Aqueduct; Child; Deglutition Disorders; Diazepam; Dysarthria; Elect | 1999 |
Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Diazepam; Emerge | 1999 |
Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995).
Topics: Animals; Anticonvulsants; Bromides; Cerebrospinal Fluid; Diazepam; Dog Diseases; Dogs; Female; Male; | 1999 |
Postoperative pseudostatus: not everything that shakes is epilepsy.
Topics: Adult; Anesthesia, General; Anticonvulsants; Contraindications; Diagnosis, Differential; Diazepam; F | 2000 |
Felbamate in experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2000 |
Nonconvulsive status epilepticus complicating neuroleptic malignant syndrome improved by intravenous diazepam.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Humans; Injections, Intravenous; Male; Middle Age | 2000 |
Comparison of plasma benzodiazepine concentrations following intranasal and intravenous administration of diazepam to dogs.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Area Under Curve; Cross-Over Studies; Diazepam | 2000 |
[Treatment of status epilepticus in a developing country].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D | 2000 |
Peripheral infusion of Diazemuls.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Fem | 2000 |
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Down-Regulation; Electrophysiology; Electroshock; Immunoh | 2000 |
Hippocampal neurons express GABA A receptor insensitive to diazepam in hyperexcitable conditions.
Topics: Animals; Dentate Gyrus; Diazepam; Epilepsy, Temporal Lobe; Hippocampus; Neurons; Patch-Clamp Techniq | 2000 |
Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators.
Topics: Age Factors; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electroencephalography; Ele | 2000 |
Treatment of nonfebrile status epilepticus in Rochester, Minn, from 1965 through 1984.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D | 2001 |
[Non-convulsive status epilepticus--confusion and cognitive failure during seizures].
Topics: Adult; Aged; Anticonvulsants; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Fema | 2000 |
Brain-derived neurotrophic factor superinduction parallels anti-epileptic--neuroprotective treatment in the pilocarpine epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diazepam; Gene Expression Regulation; Hippocampus; Male; | 2001 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Lorazepam or diazepam for generalised convulsions in adults.
Topics: Diazepam; Emergency Medical Services; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Evidence-Based | 2001 |
Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diazepam; Disease Models, Animal; Drug Therapy, | 2000 |
AIT-082 is neuroprotective against kainate-induced neuronal injury in rats.
Topics: Aminobenzoates; Analysis of Variance; Animals; Cell Survival; Dentate Gyrus; Diazepam; Electroenceph | 2001 |
Nonconvulsive status epilepticus causing acute confusion.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Female; Humans; Neuroleptic Malignant Syndrome; Status Epilepti | 2001 |
Effect of duration of pilocarpine-induced status epilepticus on subsequent cognitive function in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Diazepam; Male; Muscarinic Agonists; Pilocarpine; Rats | 2001 |
Infantile status epilepticus in Tunisia. Clinical, etiological and prognostic aspects.
Topics: Anticonvulsants; Central Nervous System Infections; Chi-Square Distribution; Child, Preschool; Clona | 2001 |
Clinical research on out-of-hospital emergency care.
Topics: Anticonvulsants; Clinical Trials as Topic; Diazepam; Emergency Medical Services; Emergency Medical T | 2001 |
Seizures may be safely treated en route to hospital.
Topics: Anticonvulsants; Diazepam; Emergency Medical Services; Humans; Injections, Intravenous; Lorazepam; S | 2001 |
Treatment of out-of-hospital status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Research Design; Status Epilepticus; | 2001 |
Status epilepticus leads to the degradation of the endogenous inhibitor of caspase-activated DNase in rats.
Topics: Animals; Anticonvulsants; Apoptosis; Apoptosis Regulatory Proteins; Brain; Deoxyribonucleases; Diaze | 2002 |
A comparison of lorazepam and diazepam as initial therapy in convulsive status epilepticus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Chi-Square Distribution; Costs and Cost | 2002 |
[Transitory burst-suppression pattern in endogenous-exogenous encephalopathy (author's transl)].
Topics: Adult; Brain Diseases; Cerebral Cortex; Diazepam; Diuretics; Electroencephalography; Female; Humans; | 1978 |
[Epileptogenic action of intra-amygdaloid injection of kainic acid].
Topics: Amygdala; Animals; Diazepam; Disease Models, Animal; Hippocampus; Injections; Kainic Acid; Male; Pyr | 1978 |
The medical treatment of epilepsy: treatment of prolonged convulsions and status epilepticus.
Topics: Adult; Anticonvulsants; Barbiturates; Child; Diazepam; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic | 1979 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
[Intraveneous therapy of petit mal status with diazepame and clonazepame (author's transl)].
Topics: Anticonvulsants; Benzodiazepinones; Child; Clonazepam; Diazepam; Electroencephalography; Female; Hum | 1977 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
[Principles for intensive therapy of status epilepticus in children].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Blood Transfusion; Blood-Brain Barrier; Child; Chil | 1979 |
Status epilepticus: discussion from experience in adult cases.
Topics: Adolescent; Adult; Clonazepam; Diazepam; Female; Humans; Phenytoin; Status Epilepticus | 1979 |
Therapy and prognosis of status convulsivus in childhood.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Japan; Male; | 1979 |
Drug therapy of status epilepticus.
Topics: Acetazolamide; Diazepam; Humans; Lidocaine; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticu | 1978 |
[Antiepileptic emergency therapy in the adult age].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi | 1978 |
[Initial treatment of status epilepticus].
Topics: Adult; Anticonvulsants; Child; Diazepam; Humans; Status Epilepticus; Time Factors | 1977 |
[Status epilepticus].
Topics: Diazepam; Humans; Phenobarbital; Status Epilepticus | 1977 |
Status epilepticus.
Topics: Adult; Amobarbital; Diazepam; Humans; Male; Phenobarbital; Phenytoin; Status Epilepticus | 1976 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Piloc | 1992 |
Role of lidocaine (lignocaine) in managing status epilepticus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Dose-Response Relationship, Drug; Evoked Poten | 1992 |
Status epilepticus. Recent experience at the Port-of-Spain General Hospital, Trinidad.
Topics: Adolescent; Adult; Child; Developing Countries; Diazepam; Female; Humans; Male; Retrospective Studie | 1992 |
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus].
Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarb | 1992 |
[Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents].
Topics: Administration, Rectal; Child, Preschool; Diazepam; Emergencies; Female; Home Nursing; Humans; Infan | 1991 |
Motor and electroencephalographic response of refractory experimental status epilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam.
Topics: Animals; Behavior, Animal; Diazepam; Dizocilpine Maleate; Drug Interactions; Electroencephalography; | 1991 |
[Atypical electroencephalographic activity in terminal phase subacute sclerosing panencephalitis].
Topics: Child; Diazepam; Electroencephalography; Humans; Male; Status Epilepticus; Subacute Sclerosing Panen | 1991 |
Rectal diazepam therapy for prehospital pediatric status epilepticus.
Topics: Administration, Rectal; Child; Diazepam; Emergency Medical Services; Humans; Status Epilepticus | 1991 |
Management of epilepsy.
Topics: Adult; Diazepam; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Monitoring, | 1990 |
[Convulsive status].
Topics: Diazepam; Humans; Lorazepam; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticus | 1990 |
Status epilepticus following the oral ingestion of cocaine in an infant.
Topics: Cocaine; Diagnosis, Differential; Diazepam; Electroencephalography; Emergencies; Humans; Infant; Mal | 1990 |
Emergency management of seizures: an overview.
Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epileptic | 1989 |
Rectal diazepam in pediatric status epilepticus.
Topics: Administration, Rectal; Child; Diazepam; Emergencies; Female; Humans; Infant; Male; Status Epileptic | 1989 |
[Grand mal seizures and status epilepticus in general practice-- what's to be done?].
Topics: Adult; Aged; Child, Preschool; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Family Pra | 1986 |
[Clinical treatment of grand mal epileptic status in adults].
Topics: Adult; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Hum | 1986 |
Acute confusional state with status petit mal as a withdrawal syndrome--and five year follow-up.
Topics: Acute Disease; Cognition Disorders; Confusion; Diazepam; Follow-Up Studies; Humans; Injections, Intr | 1988 |
Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam.
Topics: Analysis of Variance; Animals; Diazepam; Electroencephalography; Lithium; Pilocarpine; Reaction Time | 1988 |
[Febrile seizures].
Topics: Adolescent; Carbamates; Child; Child, Preschool; Diazepam; Female; Humans; Male; Risk Factors; Seizu | 1987 |
[A critical confusion state of frontal origin in elderly subjects: difficult diagnosis].
Topics: Acute Disease; Aged; Aged, 80 and over; Cognition Disorders; Confusion; Diazepam; Electroencephalogr | 1987 |
Effects of drugs on the initiation and maintenance of status epilepticus induced by administration of pilocarpine to lithium-pretreated rats.
Topics: Animals; Anticonvulsants; Atropine; Diazepam; Electroencephalography; Lithium; Male; Paraldehyde; Ph | 1987 |
Rectal administration of diazepam.
Topics: Administration, Rectal; Diazepam; Humans; Status Epilepticus | 1987 |
Status epilepticus due to abrupt diazepam withdrawal: a case report.
Topics: Adult; Diazepam; Humans; Male; Status Epilepticus; Substance Withdrawal Syndrome | 1986 |
Status epilepticus facilitated by pilocarpine in amygdala-kindled rats.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pilocarpine; Rats; Ra | 1986 |
Non-convulsive status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Chlormethiazole; Diazepam; Electroencephalography; Female; | 1987 |
Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats.
Topics: Animals; Atropine; Diazepam; Drug Synergism; Electroencephalography; Hemicholinium 3; Lithium; Male; | 1986 |
Refractory status epilepticus in pregnancy. A case report.
Topics: Anticonvulsants; Diazepam; Female; Humans; Phenytoin; Pregnancy; Pregnancy Complications; Status Epi | 1985 |
Endotracheal diazepam in status epilepticus.
Topics: Aged; Diazepam; Emergencies; Female; Humans; Status Epilepticus; Tracheotomy | 1985 |
Status epilepticus.
Topics: Adult; Aged; Anticonvulsants; Diazepam; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; | 1985 |
Status epilepticus in pregnancy. A case report.
Topics: Adolescent; Diazepam; Female; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin; Pregnancy; Pr | 1985 |
Status epilepticus.
Topics: Anesthesia, General; Child; Diazepam; Humans; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepti | 1985 |