diazepam has been researched along with Absence Seizure in 1193 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke." | 9.41 | Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial. ( Aldenkamp, AP; Rouhl, RPW; van Oostenbrugge, RJ; van Raak, EPM; van Tuijl, JH, 2021) |
| "Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration." | 9.41 | Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| " Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years." | 9.41 | Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021) |
| "A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters." | 9.41 | Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states." | 9.34 | Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 9.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "Part 1 of this phase III study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter study of caregiver administered diazepam auto-injector (AI) in subjects with acute repetitive seizures (ARS) and demonstrated that diazepam AI was well-tolerated and significantly more effective than placebo AI in delaying the time to next seizure or rescue." | 9.19 | Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures. ( Abou-Khalil, B; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, KW; Wheless, J; Wolter, KD, 2014) |
| "The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures." | 9.17 | A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures. ( Shanbag, P; Thakker, A, 2013) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 9.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| " Our aim was to evaluate the efficacy and usability of buccal midazolam in controlling seizures in children with acute prolonged seizures, by comparing it with rectal diazepam." | 9.14 | Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children. ( Ashrafi, MR; Bavarian, B; Karimi, P; Khosroshahi, N; Kompani, F; Malamiri, RA; Mirzaei, M; Zarch, AV, 2010) |
| "To compare the efficacy of midazolam and diazepam for treatment of acute seizures in children." | 9.14 | [A control study on the treatment of acute seizures with midazolam and diazepam in children]. ( Tang, RH; Zhou, JB, 2010) |
| "Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children." | 9.13 | Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, S, 2008) |
| "To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures." | 9.12 | Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures. ( Manohar, R; Mittal, P; Rawat, AK, 2006) |
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 9.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "To evaluate the efficacy and tolerability of diazepam (DZP) rectal gel (Diastat; Elan Pharmaceuticals, Dublin, Ireland) for the treatment of acute repetitive seizures in adult patients in 2 multicenter, double-blind, placebo-controlled parallel studies." | 9.10 | Rectal diazepam gel for treatment of acute repetitive seizures in adults. ( Cereghino, JJ; Cloyd, JC; Kuzniecky, RI, 2002) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 9.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 9.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "Intranasal administration of diazepam may be a practical alternative to the conventional acute medication of seizures, such as status epilepticus." | 9.09 | Intranasal administration of diazepam aiming at the treatment of acute seizures: clinical trials in healthy volunteers. ( Bechgaard, E; Gizurarson, S; Gudbrandsson, FK; Jónsson, H, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 9.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| "Benzodiazepines, including diazepam and midazolam, are the mainstay of treatment for seizure emergencies, including acute repetitive seizures." | 9.01 | Diazepam buccal film for the treatment of acute seizures. ( Heller, AH; Rogawski, MA, 2019) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 8.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| "A short cut review was carried out to establish whether buccal midazolam is better than rectal diazepam for treating prolonged seizures in childhood and adolescence." | 8.82 | Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence. ( Body, R; Ijaz, M, 2005) |
| " Although she was initially treated with intravenous diazepam, her seizures persisted." | 8.31 | Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. ( Imai, T; Iwabuchi, S; Kinoshita, K; Matsuoka, M, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| "We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures." | 8.31 | Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023) |
| " Conversely, higher dose of anandamide, AM404, URB597 (100 µg/mouse) as well as capsaicin (a TRPV1 agonist: 1, 10, or 100 µg/mouse) attenuated the protective effect of diazepam against PTZ-induced seizures." | 8.12 | Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice. ( Manna, SSS, 2022) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 8.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 8.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| "We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting." | 8.02 | Blood concentration of levetiracetam after bolus administration in patients with status epilepticus. ( Hotta, M; Kaneko, J; Kondo, M; Kubota, M; Kuno, M; Nagano, M; Sugaya, K; Tagami, T; Takase, H; Unemoto, K, 2021) |
| " Here, we characterize seizures induced with kainic acid (KA) in the common marmoset (Callithrix jacchus)." | 7.96 | Kainic acid-induced seizures in the common marmoset. ( Ishikawa, A; Maki, T; Mizuno, Y; Niimi, K; Oda, Y; Sakai, K; Takahashi, E; Tanaka, R, 2020) |
| "To describe a case of mannitol overdose associated with acute kidney injury (AKI), hypertonic hyponatremia, and neurologic abnormalities in a dog." | 7.91 | Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog. ( Aumann, M; Clabots, MF; Gaillard, E, 2019) |
| "A previous European cost-utility study reported that use of buccal midazolam in the community setting for the treatment of prolonged seizures (ie, seizures lasting ≥5 minutes) in children was associated with an overall €12 507 399 reduction in annual costs charged to the Italian national health service compared with rectal diazepam." | 7.88 | Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach. ( Beghi, E; Capovilla, G; Franzoni, E; Minicucci, F; Perucca, E; Romeo, A; Verrotti, A; Vigevano, F, 2018) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 7.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| "Our data demonstrate an anticonvulsant effect of bumetanide on KA-induced seizures in adult mice, suggesting a role for chloride plasticity in seizure progression." | 7.83 | Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. ( Maguire, J; Sivakumaran, S, 2016) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 7.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| " The aim of the present study was to investigate the influence of duration of treatment, as well as the role of α1-containing GABAA receptors, in development of physical dependence to diazepam, assessed through the level of anxiety and susceptibility to pentylenetetrazole (PTZ)-induced seizures, 24h after withdrawal from protracted treatment in rats." | 7.80 | Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. ( Batinić, B; Cook, JM; Joksimović, S; Kovačević, J; Milić, M; Namjoshi, OA; Savić, MM; Timić, T; Tiruveedhula, VV, 2014) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 7.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| " We evaluated the effect of field diazepam and other potential risk factors on the occurrence of apnea, defined as the need for airway management, that is, bag-mask ventilation by paramedics or bag-mask ventilation or intubation by PED staff within 30 minutes of arrival." | 7.80 | Risk factors for apnea in children presenting with out-of-hospital seizure. ( Bosson, N; Gausche-Hill, M; Kaji, AH; Khodabakhsh, D; Lee, J; Squire, B, 2014) |
| " Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes SE and severe recurrent seizures as a result of exposure." | 7.78 | Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure. ( Addis, M; Bailey, K; Chanda, S; de Araujo Furtado, M; Lumley, LA; Moffett, M; Pak, T; Robertson, BD; Rossetti, F; Shields, M; Yourick, DL, 2012) |
| "Oromucosal midazolam (Buccolam™), a benzodiazepine, is approved in the EU for the treatment of paediatric patients (aged 3 months to <18 years) with acute, prolonged, convulsive seizures." | 7.78 | Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP; Lyseng-Williamson, KA; Scott, LJ, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 7.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| "Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy." | 7.77 | Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011) |
| "In this retrospective study of institutionalized patients with mental retardation, we present the efficacy and safety of sequential treatment with intrarectal diazepam (IRD) gel (Diastat) and intravenous levetiracetam (IVL) in comparison with either treatment alone for acute repetitive or prolonged seizures (ARPS)." | 7.76 | Sequential intrarectal diazepam and intravenous levetiracetam in treating acute repetitive and prolonged seizures. ( Milteer, WE; Modur, PN; Zhang, S, 2010) |
| "The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels." | 7.76 | Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010) |
| "Near-lethal exposure to nerve agents produces prolonged epileptiform seizures requiring the administration of benzodiazepine anticonvulsant drugs, such as diazepam." | 7.76 | Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs. ( McDonough, JH; McMonagle, JD; Shih, TM, 2010) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 7.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| " In this study, we investigated the basic mechanism of aminophylline [theophylline-2-ethylenediamine]-induced convulsions and the effects of Brewer's yeast-induced pyrexia in mice." | 7.75 | Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K, 2009) |
| "Two guinea pig models were used to study the anticonvulsant potency of diazepam, midazolam, and scopolamine against seizures induced by the nerve agents tabun, sarin, soman, cyclosarin, O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate (VX), and O-isobutyl S-(2-diethylamino)ethyl)-methyl phosphonothioate (VR)." | 7.74 | Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine. ( McDonough, JH; Rowland, TC; Shih, TM, 2007) |
| "To reveal the efficacy of single-dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis." | 7.74 | Single-dose chloral hydrate for benign convulsions with mild gastroenteritis. ( Enoki, H; Matsubayashi, R; Matsubayashi, T; Nagasaki, R; Nakashima, Y; Ohro, Y; Takeda, S; Yokota, T, 2007) |
| "The IN-MAD midazolam controlled seizures better than PR diazepam in the prehospital setting and resulted in fewer respiratory complications and fewer admissions." | 7.74 | Prehospital intranasal midazolam for the treatment of pediatric seizures. ( Filloux, FM; Firth, SD; Furnival, RA; Holsti, M; Joyce, SM; Sill, BL, 2007) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 7.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| " A tracheostomy was established to relieve airway obstruction, and ketamine was added to the medication when breakthrough seizures were refractory to diazepam." | 7.74 | Ketamine in the management of generalised cephalic tetanus. ( Amadasun, JE; Obanor, O; Osazuwa, HO, 2008) |
| "Exposure to the organophosphate nerve agent soman produces seizures that in turn lead to neuropathology." | 7.73 | Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging. ( Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A, 2005) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 7.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 7.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 7.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole." | 7.72 | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. ( Li, CL; Song, HR; Wang, YL; Wu, CF; Yang, JY; Zhang, HF, 2003) |
| "To determine which is the most effective and safe treatment for controlling seizures in children out-of-hospital: diazepam or midazolam." | 7.71 | Controlling seizures in the prehospital setting: diazepam or midazolam? ( Browne, GJ; Lam, LT; Rainbow, J, 2002) |
| "A seven-year-old boy with sickle cell anemia was admitted to the emergency department with severe pain unresponsive to high doses of oral acetaminophen; subsequently, intravenous codeine phosphate was administered." | 7.71 | Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001) |
| "These studies investigated the effectiveness of combination treatment with a benzodiazepine and an anticholinergic drug against soman-induced seizures." | 7.71 | Combination anticonvulsant treatment of soman-induced seizures. ( Koplovitz, I; Macalalag, R; McDonough, J; Railer, R; Schons, M; Schulz, S; Shutz, M, 2001) |
| "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus." | 7.70 | Refractory status epilepticus in children: role of continuous diazepam infusion. ( Banerjee, S; Singhi, P; Singhi, S, 1998) |
| "The present study investigated the role of NMDA (N-methyl-D-aspartate) receptors in the hypersusceptibility to seizures induced by the benzodiazepine inverse agonist DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) during diazepam withdrawal in mice, using behavioral and biochemical approaches." | 7.70 | Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The aim of this study was to determine the incidence of respiratory depression following the use of diazepam in children presenting with seizures." | 7.70 | Respiratory depression in children receiving diazepam for acute seizures: a prospective study. ( Choonara, I; Marzouk, O; McIntyre, J; Norris, E; Nunn, A, 1999) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 7.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| "The acetylcholinesterase inhibitor, soman, induces marked and sustained hypertension and tachycardia associated with a convulsive syndrome in rats." | 7.70 | Soman-induced hypertension in conscious rats is mediated by prolonged central muscarinic stimulation. ( Barrès, C; Bataillard, A; Baubichon, D; Julien, C; Lallement, G; Létienne, R, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 7.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 7.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 7.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage." | 7.69 | The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam. ( Baran, H; Löscher, W; Mevissen, M, 1994) |
| " Lithium pretreatment potentiated IEG expression induced by 30 mg/kg pilocarpine, likely as a result of the seizures caused by this combination of drugs because pretreatment with anticonvulsants (diazepam or MK-801) blocked seizures and the enhanced IEG mRNA levels." | 7.69 | Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications." | 7.69 | Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications. ( Albertson, TE; Derlet, RW, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 7.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 7.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 7.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 7.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized." | 7.68 | [Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum]. ( Golovko, AI; Sofronov, GA, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 7.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| "This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 7.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
| " The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction." | 7.68 | Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991) |
| " We studied the effects of a calcium antagonist diltiazem, as well as diazepam and phenytoin on hyperthermia induced seizures in unrestrained 15 day-old rats." | 7.68 | Effects of diltiazem on hyperthermia induced seizures in the rat pup. ( Carrillo, E; Laorden, ML; Miralles, FS; Puig, MM, 1990) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 7.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| "The anticonvulsive activity of cholecystokinin octapeptide sulphate ester (CCK-8-SE), non-sulphated cholecystokinin octapeptide (CCK-8-NS) and three different N- and C-terminal fragments were investigated against seizures induced by picrotoxin and electroshock in rats after intracerebroventricular administration." | 7.67 | Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration. ( Kádár, T; Penke, B; Pesti, A; Telegdy, G, 1984) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 7.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| " Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%." | 7.67 | Diazepam in the prevention of seizures and death in cocaine-intoxicated rats. ( Albertson, TE; Derlet, RW, 1989) |
| "We report four cases of unexpected cocaine intoxication in children manifested by the sudden development of seizures." | 7.67 | Unexpected cocaine intoxication presenting as seizures in children. ( Ernst, AA; Sanders, WM, 1989) |
| "The effects of seizures induced by an acute administration of bicuculline have been investigated on the central benzodiazepine and adenosine receptors in developing rats and in adults." | 7.67 | Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain. ( Daval, JL; Sarfati, A, 1987) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 7.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 7.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 7.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 7.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| "Twenty patients withdrawing from alcohol who had reliable histories of previous alcohol-withdrawal seizures and thus were at high risk for a subsequent seizure were treated in hospital with oral diazepam loading: 20 mg of the drug was given every hour to a minimum total of 60 mg." | 7.67 | Prevention of alcohol withdrawal seizures with oral diazepam loading. ( Devenyi, P; Harrison, ML, 1985) |
| "Acute administration of phenytoin (40 and 75 mg/kg) was unable to counteract seizures induced by pentylenetetrazole and even prolonged them in some cases." | 7.67 | Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse. ( File, SE; Pellow, S; Wilks, L, 1985) |
| " We determined the effects of the anticonvulsant, diazepam (DZ) on MSO seizures and on brain levels of S-adenosyl-L-methionine (AdoMet) and S-adenosyl-L-homocysteine (AdoHcy) to indicate possible alterations in the brain methylation pathway." | 7.67 | The effect of diazepam on brain levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine: possible correlation with protection from methionine sulfoximine seizures. ( Gill, MW; Schatz, RA, 1985) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 7.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| "Caerulein, cholecystokinin octapeptide (CCK-8) and diazepam delayed the onset of seizures produced by harman and thiosemicarbazide (TSC)." | 7.66 | Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid. ( Zetler, G, 1981) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 7.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "Diazepam (1 mg/kg) was more effective than diphenylhydantoin (100 mg/kg) in suppressing motor seizures elicited in kindled rats by amygdaloid stimulation; however, the effect of these drugs on the incidence of spontaneous motor seizures in rats kindled by amygdaloid stimulation was just the opposite." | 7.66 | Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: a double dissociation. ( Pinel, JP, 1983) |
| "A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass." | 7.66 | Amoxapine intoxication in an infant: seizures arrested with diazepam. ( Shepard, FM, 1983) |
| "A comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal Papio papio." | 7.66 | Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital. ( Killam, EK; Weinberger, SB, 1978) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 7.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| "Diazepam was initially administered, followed intravenously by FPHT at 22." | 7.30 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial. ( Asami, M; Egawa, S; Fukuda, Y; Hoshiyama, E; Inoue, Y; Ishikawa, E; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Matsumaru, Y; Mochizuki, M; Nakamoto, H; Nakamura, K; Takahashi, Y; Uchida, M; Unemoto, K; Yamada, T; Yonekawa, C, 2023) |
| " Safety assessments included treatment-emergent adverse events (TEAEs)." | 7.11 | Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 6.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Diazepam rectal gel was effective in stopping seizures in 45 patients (90%)." | 6.73 | Effectiveness of diazepam rectal gel in adults with acute repetitive seizures and prolonged seizures: a single-center experience. ( Bensalem-Owen, M; Chumley, A; Fakhoury, T, 2007) |
| "An inhaled benzodiazepine as a seizure rescue drug is currently undergoing clinical trials." | 6.72 | A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures. ( Higdon, LM; Sperling, MR, 2021) |
| "Diastat treatment reduced median seizure frequency (p = 0." | 6.69 | Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. ( Cereghino, JJ; Kriel, RL; Mitchell, WG; Murphy, J; Rosenfeld, WE; Trevathan, E, 1998) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 6.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| "On 2/3 of all occasions the seizure was interrupted in less than 15 min." | 6.65 | Diazepam rectal solution for home treatment of acute seizures in children. ( Hoppu, K; Santavuori, P, 1981) |
| "In contrast, the same ES inhibited EEG seizures when delivered after a combination of DIA‑1." | 5.56 | Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats. ( Godlevsky, LS; Pervak, MP; Shandra, AA; Shandra, OO, 2020) |
| "An exploratory analysis from a long-term, phase 3, open-label, repeat-dose safety study of diazepam nasal spray for acute treatment of seizure clusters assessed the use of a second dose up to 24 hours after the initial dose and effectiveness in potentially reducing the number of seizures." | 5.51 | Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Dlugos, D; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Wheless, JW, 2022) |
| " This study is aimed to evaluate the ability of DDS, alone or in combination with DZP starting their administration once the SE is onset to evaluate the control of seizures in rats." | 5.51 | Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats. ( Baron-Flores, V; Caballero-Chacón, S; Díaz-Ruiz, A; Farfán-Briseño, AC; Franco-Pérez, J; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Nava-Ruiz, C; Ríos, C; Ruiz-Diaz, A, 2019) |
| "Cessation of seizure was achieved in 85% of the adults and in 97% of the children, if all options of the MTAS-EMS were used." | 5.51 | Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis. ( Baulig, W; Dette-Oltmann, K; Mariotti, S; Schenk, P; Theusinger, OM, 2019) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 5.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker." | 5.42 | Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. ( Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST, 2015) |
| "We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke." | 5.41 | Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial. ( Aldenkamp, AP; Rouhl, RPW; van Oostenbrugge, RJ; van Raak, EPM; van Tuijl, JH, 2021) |
| "Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration." | 5.41 | Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| " Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years." | 5.41 | Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021) |
| " Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age." | 5.41 | Consistent safety and tolerability of Valtoco ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters." | 5.41 | Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote." | 5.40 | Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. ( Austin, AT; Banks, CN; Bruun, DA; Hammock, BD; Inceoglu, B; Lein, PJ; Rogawski, MA; Tancredi, DJ; Vito, ST; Zolkowska, D, 2014) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 5.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "He also had visual hallucinations and temporary high blood pressure." | 5.37 | Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 5.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states." | 5.34 | Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 5.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 5.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "Latency and incidence of a clonic seizure were recorded." | 5.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| "Numbers of ictal events (seizure) and latency to the first event were reduced by prophylactic DZP." | 5.32 | Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. ( Anschel, DJ; Fisher, RS; Ortega, E, 2004) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 5.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "Seizures are commonly associated with hypoxic-ischemic encephalopathy." | 5.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 5.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures." | 5.30 | Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998) |
| "Gacyclidine was injected (i." | 5.30 | Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support. ( Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M, 1999) |
| " In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min." | 5.29 | Pharmacological modulation of soman-induced seizures. ( McDonough, JH; Shih, TM, 1993) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 5.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 5.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 5.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "Seizures were repetitive and death occurred in 10." | 5.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 5.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| "Time to first convulsion and time to death were recorded over the next 7 h and all groups were monitored over the next 7 days." | 5.28 | Modulation of monomethylhydrazine-induced seizures by ivermectin. ( Horton, ML; Mayer, TW, 1991) |
| "AOAA also induced clonic convulsions in mice subjected to intracerebroventricular administration of the drug with a CD50 of 0." | 5.28 | Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. ( Calderazzo-Filho, LS; Cavalheiro, EA; Dziki, M; Turski, WA; Urbanska, E, 1991) |
| "In 75 occasions, the convulsion stopped within a period of 2 to 5 minutes, in 12 other times there was a need for repeated dosages and in 2 occasions, a third doses was needed." | 5.28 | [Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents]. ( Calderón González, R, 1991) |
| "The ED50s to inhibit seizure pattern in EEG were 30." | 5.27 | Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats. ( Kamei, C; Sunami, A; Tasaka, K, 1983) |
| "Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline." | 5.27 | Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats. ( Albertson, TE; Foulke, GE, 1987) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 5.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "kainic acid were a decrease in noradrenaline and an increase in 5-hydroxyindoleacetic acid in the acute (3 h after kainic acid injection) suggesting strongly increased neurotransmitter turnover in noradrenergic and serotonergic neurons." | 5.27 | Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures. ( Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G, 1985) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 5.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "Diazepam was found to block the generalized component of the cortico-generalized electrographic and motor seizure leaving the tonus only slightly suppressed." | 5.26 | The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures. ( Burnham, WM; Livingston, K; Racine, R, 1979) |
| "Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy." | 5.26 | Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976) |
| "Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC." | 5.26 | Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. ( Consroe, P; Eisenstein, D; Martin, P, 1977) |
| " For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 5.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
| " Head-to-head trials comparing buccal versus intranasal midazolam versus rectal diazepam would provide useful information to inform the management of the first stage of convulsive status epilepticus in adults, especially when intravenous or intramuscular access is not feasible." | 5.22 | Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence. ( Aucott, L; Booth, C; Brazzelli, M; Counsell, C; Cruickshank, M; Imamura, M; Manson, P; Scotland, G, 2022) |
| "The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam." | 5.20 | Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. ( Azizi Malamiri, R; Fayezi, A; Jafari, M; Maraghi, E; Momen, AA; Nikkhah, A; Riahi, K, 2015) |
| "Part 1 of this phase III study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter study of caregiver administered diazepam auto-injector (AI) in subjects with acute repetitive seizures (ARS) and demonstrated that diazepam AI was well-tolerated and significantly more effective than placebo AI in delaying the time to next seizure or rescue." | 5.19 | Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures. ( Abou-Khalil, B; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, KW; Wheless, J; Wolter, KD, 2014) |
| "The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures." | 5.17 | A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures. ( Shanbag, P; Thakker, A, 2013) |
| "To compare the efficacy and tolerability of buccal midazolam with rectal diazepam as emergency treatment in residential adults with convulsive or non-convulsive serial seizures or status epilepticus (SE), and ascertain the preference between the two treatment options among the patients and the nursing staff." | 5.15 | Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus. ( Lossius, MI; Nakken, KO, 2011) |
| " Our aim was to evaluate the efficacy and usability of buccal midazolam in controlling seizures in children with acute prolonged seizures, by comparing it with rectal diazepam." | 5.14 | Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children. ( Ashrafi, MR; Bavarian, B; Karimi, P; Khosroshahi, N; Kompani, F; Malamiri, RA; Mirzaei, M; Zarch, AV, 2010) |
| "To compare the efficacy of midazolam and diazepam for treatment of acute seizures in children." | 5.14 | [A control study on the treatment of acute seizures with midazolam and diazepam in children]. ( Tang, RH; Zhou, JB, 2010) |
| "Our goal was to compare the efficacy and safety of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children." | 5.13 | Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, S, 2008) |
| " Randomized controlled/prospective randomized trials comparing IN midazolam against IV/rectal BDZ in the treatment of acute seizures in pediatric patients were included in the meta-analysis." | 5.12 | Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis. ( Chhabra, R; Gupta, LK; Gupta, R, 2021) |
| "To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures." | 5.12 | Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures. ( Manohar, R; Mittal, P; Rawat, AK, 2006) |
| "To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam." | 5.11 | Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005) |
| "To evaluate the efficacy and tolerability of diazepam (DZP) rectal gel (Diastat; Elan Pharmaceuticals, Dublin, Ireland) for the treatment of acute repetitive seizures in adult patients in 2 multicenter, double-blind, placebo-controlled parallel studies." | 5.10 | Rectal diazepam gel for treatment of acute repetitive seizures in adults. ( Cereghino, JJ; Cloyd, JC; Kuzniecky, RI, 2002) |
| " We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures." | 5.09 | Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 5.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "Intranasal administration of diazepam may be a practical alternative to the conventional acute medication of seizures, such as status epilepticus." | 5.09 | Intranasal administration of diazepam aiming at the treatment of acute seizures: clinical trials in healthy volunteers. ( Bechgaard, E; Gizurarson, S; Gudbrandsson, FK; Jónsson, H, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 5.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| "Benzodiazepines, including diazepam and midazolam, are the mainstay of treatment for seizure emergencies, including acute repetitive seizures." | 5.01 | Diazepam buccal film for the treatment of acute seizures. ( Heller, AH; Rogawski, MA, 2019) |
| "Some guidelines or expert consensus indicate that intravenous (IV) lorazepam (LZP) is preferable to IV diazepam (DZP) for initial treatment of convulsive status epilepticus (SE)." | 4.93 | Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. ( Bacigaluppi, S; Bragazzi, NL; Brigo, F; Nardone, R; Trinka, E, 2016) |
| "A short cut review was carried out to establish whether buccal midazolam is better than rectal diazepam for treating prolonged seizures in childhood and adolescence." | 4.82 | Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence. ( Body, R; Ijaz, M, 2005) |
| " Diazepam is the most effective drug for cocaine-induced seizures." | 4.78 | Neurologic complications of cocaine abuse. ( Euerle, B; Spivey, WH, 1990) |
| " Although she was initially treated with intravenous diazepam, her seizures persisted." | 4.31 | Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion. ( Imai, T; Iwabuchi, S; Kinoshita, K; Matsuoka, M, 2023) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| "We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures." | 4.31 | Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023) |
| " A family history of seizures and a prescription for rectal diazepam were associated with a decreased likelihood of progression to RSE." | 4.31 | Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children. ( Abend, NS; Amengual-Gual, M; Anderson, A; Appavu, BL; Arya, R; Barcia Aguilar, C; Brenton, JN; Carpenter, J; Chapman, KE; Clark, J; Gaillard, WD; Gaínza-Lein, M; Glauser, T; Goldstein, J; Goodkin, H; Grinspan, Z; Guerriero, RM; Horn, PS; Huh, L; Kahoud, R; Kapur, K; Kelley, SA; Kossoff, EH; Lai, YC; Loddenkemper, T; Marquis, BO; McDonough, T; Mikati, MA; Morgan, L; Novotny, E; Ostendorf, AP; Payne, ET; Peariso, K; Piantino, J; Riviello, J; Sands, T; Stafstrom, CE; Tasker, RC; Tchapyjnikov, D; Vasquez, A; Wainwright, MS; Wilfong, A; Williams, K, 2023) |
| " Experiment 3: ECoG response to anticonvulsant treatment (Phenytoin, Phenobarbital and Diazepam) of seizures induced by association IPDE5 + PTZ." | 4.31 | Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility. ( Azevedo, JEC; de Araujo, DB; de Mello, VJ; Favacho Lopes, DC; Hamoy, AO; Hamoy, M; Martins Rodrigues, JC; Nascimento, CP; Silva, ALMD; Tiago, ACDS; Vieira, LR, 2023) |
| "The aim of this study was to review out-of-hospital use of intranasal diazepam and midazolam for treatment of acute repetitive seizures (ARS) at a typical adult epilepsy center." | 4.12 | Use of new intranasal benzodiazepines at a typical adult epilepsy center. ( Benbadis, SR; Li, C, 2022) |
| " Conversely, higher dose of anandamide, AM404, URB597 (100 µg/mouse) as well as capsaicin (a TRPV1 agonist: 1, 10, or 100 µg/mouse) attenuated the protective effect of diazepam against PTZ-induced seizures." | 4.12 | Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice. ( Manna, SSS, 2022) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 4.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| " Our data showed that micronized resveratrol decreased the occurrence of the tonic-clonic seizure stage and slowed the development of the seizures in a similar manner of diazepam." | 4.02 | Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish. ( Aguiar, GPS; Almeida, ER; Decui, L; Garbinato, C; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Schneider, SE; Siebel, AM, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 4.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| "We aimed to evaluate the blood concentration of levetiracetam (LEV), as a second-line drug, in patients with status epilepticus (SE) in an emergency clinical setting." | 4.02 | Blood concentration of levetiracetam after bolus administration in patients with status epilepticus. ( Hotta, M; Kaneko, J; Kondo, M; Kubota, M; Kuno, M; Nagano, M; Sugaya, K; Tagami, T; Takase, H; Unemoto, K, 2021) |
| "The naloxone-diazepam combination reduced the number, severity, and cumulative duration of seizures compared to tramadol use alone and reduced the number of higher-intensity seizures (level 3, 4) to a greater extent than other treatments." | 4.02 | The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study. ( Amirabadizadeh, A; Askari, M; Brent, J; Farrokhfall, K; Foadoddini, M; Megarbane, B; Mehrpour, O; Miri-Moghaddam, E; Nakhaee, S, 2021) |
| " Here, we characterize seizures induced with kainic acid (KA) in the common marmoset (Callithrix jacchus)." | 3.96 | Kainic acid-induced seizures in the common marmoset. ( Ishikawa, A; Maki, T; Mizuno, Y; Niimi, K; Oda, Y; Sakai, K; Takahashi, E; Tanaka, R, 2020) |
| " Our study aims to assess if administering lorazepam, for convulsive seizures <5 min, causes vital instability." | 3.96 | Lorazepam timing for acute convulsive seizure control (LoTASC). ( Gopal, M; Greene-Chandos, D; Hamed, M; Hussein, O; Kamdar, HA; Peters, E; Sawalha, K; Shanmugam, K; Smetana, KS; Thakur, G; Yasin, R, 2020) |
| "To describe a case of mannitol overdose associated with acute kidney injury (AKI), hypertonic hyponatremia, and neurologic abnormalities in a dog." | 3.91 | Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog. ( Aumann, M; Clabots, MF; Gaillard, E, 2019) |
| "The aims of this study were to evaluate the management of pediatric seizures carried out by parents or caregivers in an outpatient setting and to evaluate the differences in terms of immediate management and subsequent outcome when comparing the use of rectal diazepam versus buccal midazolam." | 3.91 | Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting. ( Julliand, S; Moretti, R; Rinaldi, VE; Titomanlio, L, 2019) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| "A previous European cost-utility study reported that use of buccal midazolam in the community setting for the treatment of prolonged seizures (ie, seizures lasting ≥5 minutes) in children was associated with an overall €12 507 399 reduction in annual costs charged to the Italian national health service compared with rectal diazepam." | 3.88 | Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach. ( Beghi, E; Capovilla, G; Franzoni, E; Minicucci, F; Perucca, E; Romeo, A; Verrotti, A; Vigevano, F, 2018) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 3.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| " Administration of diazepam, insertion of an airway and pyrexia perfectly predicted transport to hospital, tachycardia had a modest association, but other variables were only weak predictors of transport to hospital." | 3.88 | Pre-hospital ambulance care of patients following a suspected seizure: A cross sectional study. ( Asghar, ZB; Dickson, JM; Siriwardena, AN, 2018) |
| "Diazepam, administered by the intravenous, oral, or rectal routes, is widely used for the management of acute seizures." | 3.88 | Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats. ( Dhir, A; Rogawski, MA, 2018) |
| "A number of acridone-based oxadiazoles 11a-n have been synthesized and evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizures in mice." | 3.83 | Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents. ( Aghaei, I; Akbarzadeh, T; Emami, S; Faizi, M; Foroumadi, A; Jahani, R; Mahdavi, M; Mohammadi-Khanaposhtani, M; Shabani, M; Shafiee, A; Shamsaei Zafarghandi, N; Sharafi, Z, 2016) |
| "Our data demonstrate an anticonvulsant effect of bumetanide on KA-induced seizures in adult mice, suggesting a role for chloride plasticity in seizure progression." | 3.83 | Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. ( Maguire, J; Sivakumaran, S, 2016) |
| "Intravenous diazepam has been a first-line therapy to stop seizures in children for many years." | 3.83 | Intranasal midazolam for seizure cessation in the community setting. ( Goldman, RD; Zelcer, M, 2016) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 3.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "Status epilepticus in children was characterized by heterogeneous etiology, prolonged duration and commonly good response to midazolam only given in high doses." | 3.81 | Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus. ( Djuric, M; Jankovic, B; Kravljanac, R; Pekmezovic, T, 2015) |
| " The aim of the present study was to investigate the influence of duration of treatment, as well as the role of α1-containing GABAA receptors, in development of physical dependence to diazepam, assessed through the level of anxiety and susceptibility to pentylenetetrazole (PTZ)-induced seizures, 24h after withdrawal from protracted treatment in rats." | 3.80 | Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. ( Batinić, B; Cook, JM; Joksimović, S; Kovačević, J; Milić, M; Namjoshi, OA; Savić, MM; Timić, T; Tiruveedhula, VV, 2014) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 3.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| " We evaluated the effect of field diazepam and other potential risk factors on the occurrence of apnea, defined as the need for airway management, that is, bag-mask ventilation by paramedics or bag-mask ventilation or intubation by PED staff within 30 minutes of arrival." | 3.80 | Risk factors for apnea in children presenting with out-of-hospital seizure. ( Bosson, N; Gausche-Hill, M; Kaji, AH; Khodabakhsh, D; Lee, J; Squire, B, 2014) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| "In the current study the link among the γ-hydroxybutyrate (GHB)/pentylenetetrazole (PTZ)-induced absence-like seizures and concomitant decreases in the core temperature, as well as electroencephalographic (EEG) activity during rewarming from deep hypothermia produced by a drug-free protocol were investigated." | 3.79 | GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy. ( Andjus, PR; Ilić, TV; Ostojić, ZS; Vesković, SM, 2013) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| " Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes SE and severe recurrent seizures as a result of exposure." | 3.78 | Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure. ( Addis, M; Bailey, K; Chanda, S; de Araujo Furtado, M; Lumley, LA; Moffett, M; Pak, T; Robertson, BD; Rossetti, F; Shields, M; Yourick, DL, 2012) |
| " Administration of both the extract and diazepam (2 mg/kg) reduced spontaneous locomotory activity, potentiated hexobarbital (60 mg/kg)-induced sleeping parameters and prevented pentylenetetrazole (80 mg/kg)-induced seizures relative to the controls." | 3.78 | Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity. ( Can, OD; Ozkay, UD, 2012) |
| "Oromucosal midazolam (Buccolam™), a benzodiazepine, is approved in the EU for the treatment of paediatric patients (aged 3 months to <18 years) with acute, prolonged, convulsive seizures." | 3.78 | Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures. ( Garnock-Jones, KP; Lyseng-Williamson, KA; Scott, LJ, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 3.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| " It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam." | 3.77 | Anticonvulsant activity of embelin isolated from Embelia ribes. ( Badami, S; Mahendran, S; Thippeswamy, BS; Veerapur, VP, 2011) |
| "Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy." | 3.77 | Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011) |
| " Seizures were induced by the volatile convulsant agent flurothyl." | 3.77 | Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats. ( Khazipov, R; Minlebaev, M, 2011) |
| "05) the onset and reduced the duration of the seizures induced by picrotoxin (5 mg/kg, i." | 3.77 | Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders. ( Adio, O; Fageyinbo, S; Sowemimo, AA, 2011) |
| "In this retrospective study of institutionalized patients with mental retardation, we present the efficacy and safety of sequential treatment with intrarectal diazepam (IRD) gel (Diastat) and intravenous levetiracetam (IVL) in comparison with either treatment alone for acute repetitive or prolonged seizures (ARPS)." | 3.76 | Sequential intrarectal diazepam and intravenous levetiracetam in treating acute repetitive and prolonged seizures. ( Milteer, WE; Modur, PN; Zhang, S, 2010) |
| "The incidence of convulsion and associated factors were retrospectively analyzed in 23 patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage (SAH) who underwent a total of 31 intra-arterial infusion of fasudil hydrochloride (IAFH) procedures in 49 vessels." | 3.76 | Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. ( Enomoto, Y; Iwama, T; Yamada, K; Yoshimura, S, 2010) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| "Near-lethal exposure to nerve agents produces prolonged epileptiform seizures requiring the administration of benzodiazepine anticonvulsant drugs, such as diazepam." | 3.76 | Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs. ( McDonough, JH; McMonagle, JD; Shih, TM, 2010) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "2 s, while chemical seizures were induced by intraperitoneal injection of pentylenetetrazole at its CD97 dose (97% convulsive dose for the clonic phase)." | 3.76 | Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. ( Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN, 2010) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "This study investigated the anticonvulsant effect of 3-alkynyl selenophene (3-ASP) on pilocarpine (PC)-, pentylenetetrazole (PTZ)- and kainic acid (KA)-induced seizures and mortality in 21-day-old rats." | 3.75 | Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. ( Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA, 2009) |
| "In a previous study, the efficacy and safety of buccal midazolam was compared to that of rectal diazepam in the treatment of prolonged seizures in children aged three months to 12 years in Kampala, Uganda." | 3.75 | Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, SG, 2009) |
| "In order to assess the role of nitric oxide/cyclicGMP signaling pathway in the anticonvulsant effect of benzodiazepines, we studied the potential interaction of a phosphodiesterase type 5 inhibitor, sildenafil with the effect of diazepam on a mouse model of clonic seizures induced by intravenous infusion of GABA antagonist, pentylenetetrazole (PTZ)." | 3.75 | The interaction of sildenafil with the anticonvulsant effect of diazepam. ( Dehpour, AR; Gholipour, T; Jabbarzadeh, A; Nezami, BG; Rasouli, A; Riazi, K; Sharifzadeh, M, 2009) |
| " In this study, we investigated the basic mechanism of aminophylline [theophylline-2-ethylenediamine]-induced convulsions and the effects of Brewer's yeast-induced pyrexia in mice." | 3.75 | Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K, 2009) |
| " Tyrianthin 6 (6), scammonin 1 (8), and scammonin 2 (9) exhibited dose-dependent protective effects against pentylenetetrazole-induced seizures." | 3.74 | Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity. ( Aguirre-Crespo, F; Estrada-Soto, S; Herrera-Ruiz, M; León-Rivera, I; Mirón-López, G; Vazquez-Navarrete, L, 2007) |
| "A series of appropriate alkanolamine and amide derivatives of xanthone were prepared and evaluated for anticonvulsant activity using maximal electroshock (MES) and subcutaneous pentylenetetrazole (scMet) induced seizures, and for neurotoxicity (TOX) using the rotorod test on mice and rats." | 3.74 | Anticonvulsant activity of some xanthone derivatives. ( Antkiewicz-Michaluk, L; Marona, H; Pekala, E; Szneler, E; Walczak, M, 2008) |
| "Pasipay could dose-dependently affected minimal clonic seizures and generalized tonic-clonic seizures induced by pentylenetetrazole, through increment in seizure onset significantly." | 3.74 | Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats. ( Nassiri-Asl, M; Shariati-Rad, S; Zamansoltani, F, 2008) |
| "Two guinea pig models were used to study the anticonvulsant potency of diazepam, midazolam, and scopolamine against seizures induced by the nerve agents tabun, sarin, soman, cyclosarin, O-ethyl S-(2-(diisopropylamino)ethyl)methylphosphonothioate (VX), and O-isobutyl S-(2-diethylamino)ethyl)-methyl phosphonothioate (VR)." | 3.74 | Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine. ( McDonough, JH; Rowland, TC; Shih, TM, 2007) |
| " In the present study, we examined the ability of diazepam to reduce pentylenetetrazoLe (PTZ)-induced and maximal electroshock (MES)-induced seizures in mice containing point mutations in single (alpha1H101R, alpha2H101R or alpha5H105R) or multiple (alpha125H-->R) alpha subunits that render the resulting GABA(A) receptors diazepam-insensitive." | 3.74 | Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. ( Atack, JR; Bull, S; Dawson, GR; Fradley, RL; Garrett, EM; Goodacre, SC; Guscott, MR; Hallett, DJ; Newman, RJ; O'Meara, GF; Reynolds, DS; Rosahl, TW; Wafford, KA; Whiting, PJ, 2007) |
| "To reveal the efficacy of single-dose treatment with chloral hydrate (CH) for clustering seizures in benign convulsions with mild gastroenteritis." | 3.74 | Single-dose chloral hydrate for benign convulsions with mild gastroenteritis. ( Enoki, H; Matsubayashi, R; Matsubayashi, T; Nagasaki, R; Nakashima, Y; Ohro, Y; Takeda, S; Yokota, T, 2007) |
| "The IN-MAD midazolam controlled seizures better than PR diazepam in the prehospital setting and resulted in fewer respiratory complications and fewer admissions." | 3.74 | Prehospital intranasal midazolam for the treatment of pediatric seizures. ( Filloux, FM; Firth, SD; Furnival, RA; Holsti, M; Joyce, SM; Sill, BL, 2007) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 3.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| " A tracheostomy was established to relieve airway obstruction, and ketamine was added to the medication when breakthrough seizures were refractory to diazepam." | 3.74 | Ketamine in the management of generalised cephalic tetanus. ( Amadasun, JE; Obanor, O; Osazuwa, HO, 2008) |
| "Exposure to the organophosphate nerve agent soman produces seizures that in turn lead to neuropathology." | 3.73 | Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging. ( Bhagat, YA; Hamilton, MG; Kendall, EJ; Mikler, J; Obenaus, A, 2005) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| ") in mice chronically treated with temazepam or diazepam induced the appearance of withdrawal signs: clonic seizures, tonic convulsions and death episodes." | 3.73 | Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. ( Fidecka, S; Listos, J; Malec, D, 2005) |
| " Pharmacological effects were tested on ambulatory activity, anti-anxiety response, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced seizures in comparison to honokiol, buspirone, ethosuximide and diazepam as corresponding reference drugs." | 3.73 | Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice. ( Chávez, M; Domínguez, F; González, M; González-Trujano, ME; Martínez, AL; Orozco, S; Salgado, H, 2006) |
| " after exposure to a soman dose of 4 x LD(50) completely terminated seizures with a moderate mortality rate (25%)." | 3.73 | Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| " To determine if immediate post-traumatic events such as seizures may activate Rho, we examined RhoA activation in the brains of rats with kainic acid-induced seizures." | 3.73 | Activation of Rho after traumatic brain injury and seizure in rats. ( Deschamps, K; Dubreuil, CI; Marklund, N; McIntosh, TK; McKerracher, L, 2006) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 3.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| "The effect of the selective 5-hydroxytryptamine1B (5-HT1B) receptor agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine (CP 94253) and the 5-HT1A/1B/1D receptor agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU 24969) in maximal electroshock- and pentylenetetrazol-induced seizures in mice was examined." | 3.73 | Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. ( Chojnacka-Wójcik, E; Nikiforuk, A; Wesołowska, A, 2006) |
| "Until a few years ago, rectal diazepam (RD) was the only option available to parents and carers managing prolonged seizures." | 3.73 | Community use of intranasal midazolam for managing prolonged seizures. ( Coulthard, K; Harbord, M; Kay, D; Kyrkou, M; Kyrkou, N, 2006) |
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole." | 3.72 | Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice. ( Li, CL; Song, HR; Wang, YL; Wu, CF; Yang, JY; Zhang, HF, 2003) |
| " Housing conditions did not alter the anticonvulsant activity of diazepam or ethanol, although the anticonvulsant effect of ethanol was significantly greater against PTZ-induced seizures." | 3.72 | Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats. ( Chadda, R; Devaud, LL, 2004) |
| " One of them, soman, can induce severe epileptic seizures and brain damage for which therapy is incomplete." | 3.72 | Flunarizine: a possible adjuvant medication against soman poisoning? ( Carpentier, P; Dorandeu, F; Foquin, A; Lallement, G, 2004) |
| " longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests." | 3.71 | Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam. ( Büyükokuroğlu, ME; Demirezer, LO; Güvenalp, Z, 2002) |
| "To determine which is the most effective and safe treatment for controlling seizures in children out-of-hospital: diazepam or midazolam." | 3.71 | Controlling seizures in the prehospital setting: diazepam or midazolam? ( Browne, GJ; Lam, LT; Rainbow, J, 2002) |
| "We evaluated racemic zopiclone, its (S)- and (R)-enantiomers and a metabolite, (S)-desmethylzopiclone, for their actions on locomotor activity, rotarod performance, the elevated plus maze and the Vogel conflict test of anxiety, and electroconvulsive shock-induced seizures duration." | 3.71 | Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite. ( Carlson, JN; Glick, SD; Haskew, R; Jerussi, TP; Maisonneuve, IM; Wacker, J, 2001) |
| "A seven-year-old boy with sickle cell anemia was admitted to the emergency department with severe pain unresponsive to high doses of oral acetaminophen; subsequently, intravenous codeine phosphate was administered." | 3.71 | Seizures with intravenous codeine phosphate. ( Al Mohaimeed, SA; Zolezzi, M, 2001) |
| "These studies investigated the effectiveness of combination treatment with a benzodiazepine and an anticholinergic drug against soman-induced seizures." | 3.71 | Combination anticonvulsant treatment of soman-induced seizures. ( Koplovitz, I; Macalalag, R; McDonough, J; Railer, R; Schons, M; Schulz, S; Shutz, M, 2001) |
| "1-10 nmol; direct GABA(A) agonist); (3) YM90K (3-10 mg/kg; AMPA receptor antagonist); and (4) diazepam (2 and 5 mg/kg) and carbamazepine (5 and 20 mg/kg), two standard anticonvulsants, using the partially-kindled hippocampal model for epileptic seizures in freely moving rats." | 3.70 | Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation. ( Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M, 1998) |
| " EEG recordings and clinical observations also revealed that GK-11 prevented soman-induced seizures and motor convulsions." | 3.70 | Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11. ( Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Masqueliez, C; Mestries, JC; Peoc'h, M, 1998) |
| "To determine efficacy of continuous diazepam infusion in the treatment of refractory status epilepticus in a retrospective study, we analyzed data of 62 children admitted consecutively to our Pediatric Intensive Care Unit with a diagnosis of refractory status epilepticus." | 3.70 | Refractory status epilepticus in children: role of continuous diazepam infusion. ( Banerjee, S; Singhi, P; Singhi, S, 1998) |
| "The present study investigated the role of NMDA (N-methyl-D-aspartate) receptors in the hypersusceptibility to seizures induced by the benzodiazepine inverse agonist DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) during diazepam withdrawal in mice, using behavioral and biochemical approaches." | 3.70 | Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| "For the evaluation of glutamatergic and GABAergic transmission during seizures, rat hippocampal CA1 and CA3 areas were separately assessed by brain microdialysis, and extracelluar glutamate and GABA were measured through the course of the seizures after a systemic administration of kainic acid (KA)." | 3.70 | Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid. ( Asada, H; Ding, R; Obata, K, 1998) |
| "The effects of one and five electroshock seizures on [3H]flunitrazepam binding, diazepam-insensitive (DIS) [3H]Ro 15-4513 binding, and levels of mRNA for GABA(A) receptor alpha1, alpha4, beta3 and gamma2 subunits were examined in rats." | 3.70 | Sensitivity of the rat hippocampal GABA(A) receptor alpha 4 subunit to electroshock seizures. ( Clark, M, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| ") administration of (+/-) pentazocine (10, 30 & 50 mg/kg), a Sigma opioid agonist, resulted in a dose dependent anticonvulsant action against maximal electroshock seizures in mice." | 3.70 | Opioid receptor mediated anticonvulsant effect of pentazocine. ( Khanna, N; Khosla, R; Kohli, J, 1998) |
| "N(G)-nitro-L-arginine (NNA; an inhibitor of nitric oxide synthase) in a dose of 40 mg/kg impaired the protective activity of ethosuximide against the clonic phase of pentylenetetrazol-induced seizures in mice." | 3.70 | N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol. ( Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P, 1999) |
| "The aim of this study was to determine the incidence of respiratory depression following the use of diazepam in children presenting with seizures." | 3.70 | Respiratory depression in children receiving diazepam for acute seizures: a prospective study. ( Choonara, I; Marzouk, O; McIntyre, J; Norris, E; Nunn, A, 1999) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 3.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| " Diazepam, but not the synthetic flavonoids increased the latency to clonic seizures produced by isoniazid, thereby indicating that neither 6-bromoflavone nor 6-bromo-3'-nitroflavone display detectable intrinsic activity at GABA(A) receptors in vivo." | 3.70 | Pharmacological studies on synthetic flavonoids: comparison with diazepam. ( Griebel, G; Perrault, G; Sanger, DJ; Schoemaker, H; Tan, S, 1999) |
| "The acetylcholinesterase inhibitor, soman, induces marked and sustained hypertension and tachycardia associated with a convulsive syndrome in rats." | 3.70 | Soman-induced hypertension in conscious rats is mediated by prolonged central muscarinic stimulation. ( Barrès, C; Bataillard, A; Baubichon, D; Julien, C; Lallement, G; Létienne, R, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 3.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "The aim of this study was to evaluate the influence of 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5 H)-2,3-benzodiazepine (LY 300164), a selective non-competitive antagonist at alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptors, on the protection provided by diazepam against electrically- and chemically-evoked seizures in rodents." | 3.70 | The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| " As temporal lobe epilepsy is linked to neuronal damage in the hippocampus, we tested the effect of repeated ECS on subsequent status epilepticus (SE) induced by lithium-pilocarpine and leading to cell death and temporal epilepsy in the rat." | 3.70 | Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy. ( André, V; Ferrandon, A; Marescaux, C; Nehlig, A, 2000) |
| ") produced a prompt anticonvulsant effect in pilocarpine-induced seizures in freely moving rats." | 3.70 | Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2000) |
| "Benzodiazepines are used to treat the anxiety associated with cocaine withdrawal, as well as cocaine-induced seizures." | 3.70 | Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression. ( Lilly, SM; Tietz, EI, 2000) |
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| "We report that kainic acid-induced seizures lead to marked increases in mRNAs encoding basic and acidic fibroblast growth factors (bFGF and aFGF, respectively) and flg, one of their receptors, in the rat hippocampus." | 3.69 | aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures. ( Ben-Ari, Y; Bugra, K; Charton, G; Khrestchatisky, M; Moreau, J; Pollard, H, 1994) |
| "The anticonvulsant effects of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX), phencyclidine (PCP) and diazepam against audiogenic seizures in DBA/2 mice and against seizures induced by methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) in NMRI mice were compared." | 3.69 | Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX). ( Honoré, T; Jacobsen, P; Swedberg, MD, 1995) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 3.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage." | 3.69 | The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam. ( Baran, H; Löscher, W; Mevissen, M, 1994) |
| " Lithium pretreatment potentiated IEG expression induced by 30 mg/kg pilocarpine, likely as a result of the seizures caused by this combination of drugs because pretreatment with anticonvulsants (diazepam or MK-801) blocked seizures and the enhanced IEG mRNA levels." | 3.69 | Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. ( Jope, RS; Williams, MB, 1994) |
| "Flumazenil can unmask seizures and increase the incidence of death in a model of combined cocaine-diazepam intoxications." | 3.69 | Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications. ( Albertson, TE; Derlet, RW, 1994) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats." | 3.69 | Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1994) |
| " Both anticonvulsants tested suppressed seizures in a different manner, however triazolam exerted stronger anticonvulsive activity than the same dose of diazepam did." | 3.69 | Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam. ( Herink, J, 1995) |
| " administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline." | 3.69 | Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice. ( Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD, 1996) |
| " In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole." | 3.69 | Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996) |
| " Cats that were having cluster seizures or status epilepticus at the time of admission were treated orally with phenobarbital and with constant IV administration of diazepam." | 3.69 | Clinical management and outcome of cats with seizure disorders: 30 cases (1991-1993). ( McDonell, W; Parent, JM; Quesnel, AD, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 3.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "Death from cocaine intoxication results from one or more of the multiple mechanisms including seizures, cardiovascular collapse, or apnea." | 3.68 | Acute cocaine toxicity: the effect of agents in non-seizure-induced death. ( Albertson, TE; Derlet, RW; Tseng, CC, 1993) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 3.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| " Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation." | 3.68 | Diazepam dependence prevented by glutamate antagonists. ( Steppuhn, KG; Turski, L, 1993) |
| ") displaces [3H]flumazenil from its brain binding sites and in vivo it possesses a marked anticonflict profile in the rat Vogel conflict-punishment test and is 10 times more potent than bretazenil and 100 times more potent than diazepam or alprazolam in antagonizing bicuculline- and pentylenetetrazol-induced seizures." | 3.68 | Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors. ( Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A, 1993) |
| "2 s)-induced tonic seizures and lethality but failed to protect from aminophylline (150 mg/kg i." | 3.68 | Search for an antidote to electroconvulsion and lethality in aminophylline-sensitized mice. ( Chakrabarti, A; Chugh, Y; Sharma, PL, 1993) |
| "We studied the effects of modification of duration of seizures induced by electroconvulsive stimuli (ECS) on the changes in concentration of neuropeptide Y (NPY), neurokinin A (NKA), substance P (SP) and neurotensin (NT)-like immunoreactivity (-LI) in specific rat brain regions." | 3.68 | Electroconvulsive stimuli and brain peptides: effect of modification of seizure duration on neuropeptide Y, neurokinin A, substance P and neurotensin. ( Mathé, AA; Srinivasan, GR; Stenfors, C; Theodorsson, E, 1992) |
| " The four BZR ligands triazolam, diazepam, Ro 19-8022 (a benzoquinolizinone) and bretazenil (Ro 16-6028, an imidazobenzodiazepinone) were pharmacologically characterized in various neurological and behavioral paradigms in mice: two anticonvulsant tests (prevention of audiogenic and pentylenetetrazol-induced seizures), a conflict test which reveals both anxiolytic and sedative properties and two tests which mainly measure motor impairment (rotarod and horizontal wire test)." | 3.68 | Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies. ( Bonetti, EP; Facklam, M; Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Schoch, P, 1992) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 3.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized." | 3.68 | [Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum]. ( Golovko, AI; Sofronov, GA, 1992) |
| " The anticonvulsant effect of caerulein (125 micrograms/kg) against picrotoxin (10 mg/kg) induced seizures was abolished after 14 days diazepam, but not after haloperidol, treatment." | 3.68 | Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol. ( Harro, J; Lang, A; Soosaar, A; Vasar, E, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "The anticonvulsant effects of felbamate alone or in combination with diazepam were investigated against maximal electroshock-, pentylenetetrazol-, isoniazid- and bicuculline-induced seizures in mice." | 3.68 | Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice. ( Diamantis, W; Gels, M; Gordon, R; Sofia, RD, 1991) |
| " The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound." | 3.68 | Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. ( Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD, 1991) |
| "The use of undiluted intravenous diazepam solution administered as an enema has been recommended for the acute management of seizures when intravenous access cannot be obtained." | 3.68 | The effect of diazepam enema on the rectal mucosa of rats. ( Kilgore, DG; Powers, DL; Seigler, RS, 1991) |
| "This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 3.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
| " The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction." | 3.68 | Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991) |
| "05 mg/kg) offered no protection against electroconvulsions in mice but potentiated the anticonvulsant action of diazepam and valproate against maximal electroshock-induced seizures, decreasing the respective ED50 values from 9." | 3.68 | Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B; Wamil, A, 1990) |
| "The mechanism of action of aminophylline in prolonging seizures was tested in amygdala-kindled rats." | 3.68 | Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. ( Dragunow, M, 1990) |
| " We studied the effects of a calcium antagonist diltiazem, as well as diazepam and phenytoin on hyperthermia induced seizures in unrestrained 15 day-old rats." | 3.68 | Effects of diltiazem on hyperthermia induced seizures in the rat pup. ( Carrillo, E; Laorden, ML; Miralles, FS; Puig, MM, 1990) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 3.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| "Thirteen newborn infants (five premature, eight full term) with severe seizures and not responding to phenobarbital and diazepam received a lidocaine (LD) infusion." | 3.68 | Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. ( Bodiou, C; Olive, G; Radvanyi-Bouvet, MF; Rey, E; Richard, MO; Torricelli, A; Walti, H, 1990) |
| "The anticonvulsive activity of cholecystokinin octapeptide sulphate ester (CCK-8-SE), non-sulphated cholecystokinin octapeptide (CCK-8-NS) and three different N- and C-terminal fragments were investigated against seizures induced by picrotoxin and electroshock in rats after intracerebroventricular administration." | 3.67 | Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration. ( Kádár, T; Penke, B; Pesti, A; Telegdy, G, 1984) |
| " PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole." | 3.67 | Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance. ( File, SE, 1984) |
| " Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice." | 3.67 | Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. ( Kato, R; Muraki, T; Yamazoe, Y, 1984) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 3.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| " Pretreatment with diazepam was found to be highly effective in reducing observed seizures from 90% to 0% and reducing the incidence of death from 85% to 10%." | 3.67 | Diazepam in the prevention of seizures and death in cocaine-intoxicated rats. ( Albertson, TE; Derlet, RW, 1989) |
| "We report four cases of unexpected cocaine intoxication in children manifested by the sudden development of seizures." | 3.67 | Unexpected cocaine intoxication presenting as seizures in children. ( Ernst, AA; Sanders, WM, 1989) |
| "The drugs currently used in the emergency management of seizures are chiefly phenytoin, phenobarbital, diazepam, lorazepam, and paraldehyde." | 3.67 | Emergency management of seizures: an overview. ( Uthman, BM; Wilder, BJ, 1989) |
| "The effects of seizures induced by an acute administration of bicuculline have been investigated on the central benzodiazepine and adenosine receptors in developing rats and in adults." | 3.67 | Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain. ( Daval, JL; Sarfati, A, 1987) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 3.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures." | 3.67 | [Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity]. ( Kryzhanovskiĭ, GN; Shandra, AA, 1985) |
| " 3H-diazepam binding site density (Bmax) was significantly increased 24 hr after Stage 3 and Stage 5 kindled seizures in the hippocampus but not in the amygdala." | 3.67 | Amygdala kindled seizure stage is related to altered benzodiazepine binding site density. ( Berman, RF; Gomez, F; Tietz, EI, 1985) |
| " Our studies indicate that long-term exposure to diazepam results in: (1) a decrease in iontophoretic sensitivity to GABA in the dorsal raphe nucleus, (2) an increase in the affinity of the GABA recognition site in brain tissue and (3) an increase in susceptibility to bicuculline-induced seizures in the intact animal." | 3.67 | Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences. ( Anderson, SA; Gallager, DW; Gonsalves, SF; Malcolm, AB, 1985) |
| " ED50 value of diazepam was established against pentylenetetrazole-induced seizures in rats." | 3.67 | Apparent pA2 estimation of benzodiazepine receptor antagonists. ( Kulkarni, SK; Kunchandy, J, 1986) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 3.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| " The present study aimed at investigating the effects of microgram doses of this benzodiazepine on i) the threshold doses of either pentylenetetrazole, picrotoxin or bicuculline required to induce seizures in mice and ii) the suppression of lever pressing for food induced by the delivery of one electric footshock every ten presses in rats pretreated or not with isoniazid (64 mg/kg IP)." | 3.67 | Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents. ( Laporte, AM; Soubrié, P; Thiébot, MH, 1987) |
| " The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively." | 3.67 | A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. ( Balm, M; Coyle, JT; Markl, A; Zaczek, R, 1986) |
| "Continuous release of diazepam from subcutaneously implanted silastic capsules provided significant protection against pentylenetetrazol seizures in rats for up to 3 weeks." | 3.67 | Tolerance to anti-pentylenetetrazol effects following chronic diazepam. ( Gallager, DW; Gonsalves, SF, 1986) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 3.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 3.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| " In this model, tonic-clonic seizures are easily elicited by handling and the effects of administration of carbamazepine (CBZ), phenytoin (DPH), phenobarbital (PB), diazepam, valproic acid (VPA) and ethosuximide were quantitatively evaluated." | 3.67 | Seizure control following administration of anticonvulsant drugs in the quaking mouse. ( Abbott, LC; Bennett, GD; Finnell, RH; Taylor, SM, 1985) |
| "Twenty patients withdrawing from alcohol who had reliable histories of previous alcohol-withdrawal seizures and thus were at high risk for a subsequent seizure were treated in hospital with oral diazepam loading: 20 mg of the drug was given every hour to a minimum total of 60 mg." | 3.67 | Prevention of alcohol withdrawal seizures with oral diazepam loading. ( Devenyi, P; Harrison, ML, 1985) |
| "Acute administration of phenytoin (40 and 75 mg/kg) was unable to counteract seizures induced by pentylenetetrazole and even prolonged them in some cases." | 3.67 | Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse. ( File, SE; Pellow, S; Wilks, L, 1985) |
| " We determined the effects of the anticonvulsant, diazepam (DZ) on MSO seizures and on brain levels of S-adenosyl-L-methionine (AdoMet) and S-adenosyl-L-homocysteine (AdoHcy) to indicate possible alterations in the brain methylation pathway." | 3.67 | The effect of diazepam on brain levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine: possible correlation with protection from methionine sulfoximine seizures. ( Gill, MW; Schatz, RA, 1985) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "The combined use of di-n-propylacetate with phenazepam, diazepam, phenobarbital or phenytoin was shown to be followed by reciprocal potentiation of the anticonvulsant activity of the drugs in a variety of experimental epileptic seizures in mice according to the tests of shock and antagonism with corasole and thiosemicarbazide." | 3.66 | [Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin]. ( Kosoĭ, MIu, 1981) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 3.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| "Caerulein, cholecystokinin octapeptide (CCK-8) and diazepam delayed the onset of seizures produced by harman and thiosemicarbazide (TSC)." | 3.66 | Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid. ( Zetler, G, 1981) |
| "Enuresis is a common problem often treated effectively with imipramine hydrochloride." | 3.66 | Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981) |
| "Two female infants with nonketotic hyperglycinemia (NKH) were treated with diazepam for the control of seizures." | 3.66 | Nonketotic hyperglycinemia: treatment with diazepam--a competitor for glycine receptors. ( Hughes, JR; Matalon, R; Michals, K; Naidu, S, 1983) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice." | 3.66 | Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam. ( File, SE, 1983) |
| "Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
| " Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another beta-carboline, harmaline." | 3.66 | Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216. ( Cain, M; Cook, J; Paul, S; Schweri, M; Skolnick, P, 1982) |
| "Diazepam (1 mg/kg) was more effective than diphenylhydantoin (100 mg/kg) in suppressing motor seizures elicited in kindled rats by amygdaloid stimulation; however, the effect of these drugs on the incidence of spontaneous motor seizures in rats kindled by amygdaloid stimulation was just the opposite." | 3.66 | Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: a double dissociation. ( Pinel, JP, 1983) |
| "A 15-month-old infant had hyperpyrexia and severe generalized seizures without cardiovascular toxicity after the ingestion of 250 mg of amoxapine, a new tricyclic antidepressant of the dibenzoxapine subclass." | 3.66 | Amoxapine intoxication in an infant: seizures arrested with diazepam. ( Shepard, FM, 1983) |
| "Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats." | 3.66 | Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. ( McNamara, JO; Patrone, V; Peper, AM, 1980) |
| "A comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal Papio papio." | 3.66 | Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital. ( Killam, EK; Weinberger, SB, 1978) |
| "Intra-amygdaloid unilateral application of low doses of kainic acid rapidly elicits, in both chronic and acute conditions, secondarily generalized convulsive seizures which often culminate in fatal true status epilepticus unless appropriate anti-epileptic drugs are provided." | 3.66 | [Epileptogenic action of intra-amygdaloid injection of kainic acid]. ( Ben-Ari, Y; Lagowska, J, 1978) |
| " Metrizamide-induced seizures could be prevented by intramuscular preadministration of diazepam." | 3.66 | Cat optic nerve imaging with metrizamide. ( Davis, JP; Eldevik, OP; Gager, WE; Harris, GJ; Haughton, VM, 1979) |
| "In a prospective study 44 children, aged 6 months to 5 years, admitted to hospital with febrile convulsions or epilepsy, were treated with diazepam in solution administered rectally during 59 generalised attacks." | 3.66 | Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. ( Knudsen, FU, 1979) |
| "Seizures induced in the rat by electroshock or by injections of pentylenetetrazol increase the specific binding of diazepam to putative receptor sites in cerebral cortical membranes." | 3.66 | Rapid changes in brain benzodiazepine receptors after experimental seizures. ( Paul, SM; Skolnick, P, 1978) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 3.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "Attempts were made to control prolonged seizures with rapid intravenous administration of either diazepam or methohexitone in relatively small doses under electroencephalographic (EEG) monitoring." | 3.65 | Intravenous therapy and EEG monitoring in prolonged seizures. ( Da Costa, AA; Pampiglione, G, 1975) |
| "Diazepam was initially administered, followed intravenously by FPHT at 22." | 3.30 | Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial. ( Asami, M; Egawa, S; Fukuda, Y; Hoshiyama, E; Inoue, Y; Ishikawa, E; Kaneko, J; Kimura, A; Kondo, Y; Maruo, K; Marushima, A; Matsumaru, Y; Mochizuki, M; Nakamoto, H; Nakamura, K; Takahashi, Y; Uchida, M; Unemoto, K; Yamada, T; Yonekawa, C, 2023) |
| "This study in healthy volunteers demonstrated that food significantly decreases and delays the absorption of diazepam dosed via nasal spray." | 3.30 | A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults. ( Rogawski, MA; Slatko, G, 2023) |
| " Concomitant CBD use was recorded, and treatment-emergent adverse events (TEAEs) were collected." | 3.30 | Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study. ( Carrazana, E; Misra, SN; Peters, JM; Puri, V; Rabinowicz, AL; Segal, E, 2023) |
| " Across groups, treatment-emergent adverse event rates ranged from 66." | 3.30 | Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study. ( Carrazana, E; Misra, SN; Rabinowicz, AL; Segal, EB; Tarquinio, D; Wheless, JW, 2023) |
| " Safety assessments included treatment-emergent adverse events (TEAEs)." | 3.11 | Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022) |
| " In addition, safety measures, including treatment-emergent adverse events, are reported." | 3.11 | Quality-of-life results in adults with epilepsy using diazepam nasal spray for seizure clusters from a long-term, open-label safety study. ( Carrazana, E; Cramer, JA; Davis, C; Faught, E; Misra, SN; Rabinowicz, AL, 2022) |
| "Epilepsy is a chronic disease of the central nervous system characterized by recurrent epileptic seizures." | 3.01 | Second Generation of Antiepileptic Drugs and Oxidative Stress. ( Czuczwar, SJ; Kamieniak, M; Kośmider, K; Miziak, B, 2023) |
| "Patients with epilepsy can experience seizure clusters (acute repetitive seizures), defined as intermittent, stereotypic episodes of frequent seizure activity that are distinct from typical seizure patterns." | 3.01 | Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications. ( Bougher, G; Dean, P; Desai, J; Dewar, S; Misra, SN; O'Hara, K, 2023) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 2.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| " Outcomes included incident seizures, delirium tremens, AW severity scores, adverse events, dropouts, dropouts from adverse events, length of hospital stay, use of additional medications, total benzodiazepine requirements, and death." | 2.82 | Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis. ( Bach, P; Bahji, A; Crockford, D; Danilewitz, M; Devoe, DJ; El-Guebaly, N; Saitz, R, 2022) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus." | 2.82 | Rescue therapies for seizure clusters: Pharmacology and target of treatments. ( Detyniecki, K; Gidal, B, 2022) |
| "Diazepam rectal gel is an effective rescue therapy for seizure clusters, though adults and adolescents may have social reservations regarding its administration." | 2.82 | Rescue Treatments for Seizure Clusters. ( Gidal, BE; Kotloski, RJ, 2022) |
| "We aimed to inquire whether any seizure rescue medications are included in the in-flight medical emergency kits of the main airlines in the world." | 2.82 | Seizure rescue medications are missing from in-flight medical emergency kits. ( Asadi-Pooya, AA; Hosseini, SA, 2022) |
| "Sublingual lorazepam stopped seizures within 10 minutes of administration in 56% of children compared with intrarectal diazepam in 79% (P < ." | 2.79 | Efficacy of sublingual lorazepam versus intrarectal diazepam for prolonged convulsions in Sub-Saharan Africa. ( Dubru, JM; Kahamba, DM; Kokolomani, J; Malu, CK; Mayamba, RM; Misson, JP; Mukampunga, C; Musalu, EM; Walker, TD; Wilmshurst, JM, 2014) |
| "For diazepam group it was 84." | 2.77 | Intravenous diazepam, midazolam and lorazepam in acute seizure control. ( Gathwala, G; Goel, M; Mittal, K; Singh, J, 2012) |
| "Partial seizures, generalized tonic, clonic and tonic-clonic convulsions were included irrespective of duration or cause." | 2.74 | Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial. ( Chakrabarty, B; Talukdar, B, 2009) |
| "Diazepam rectal gel was effective in stopping seizures in 45 patients (90%)." | 2.73 | Effectiveness of diazepam rectal gel in adults with acute repetitive seizures and prolonged seizures: a single-center experience. ( Bensalem-Owen, M; Chumley, A; Fakhoury, T, 2007) |
| "However, most seizure emergencies start outside the hospital settings." | 2.72 | Rescue therapies for seizure emergencies: current and future landscape. ( Samanta, D, 2021) |
| "An inhaled benzodiazepine as a seizure rescue drug is currently undergoing clinical trials." | 2.72 | A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures. ( Higdon, LM; Sperling, MR, 2021) |
| "Diastat treatment reduced median seizure frequency (p = 0." | 2.69 | Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. ( Cereghino, JJ; Kriel, RL; Mitchell, WG; Murphy, J; Rosenfeld, WE; Trevathan, E, 1998) |
| "Hemodialysis-associated seizure (HAS) is a common complication of hemodialysis." | 2.69 | Potential prophylactic use of benzodiazepines for hemodialysis-associated seizures. ( Mir, S; Sönmez, F; Tütüncüoğlu, S, 2000) |
| "Of 467 patients with preeclampsia or superimposed preeclampsia managed without seizure prophylaxis, 18 had seizure activity, 3." | 2.68 | The feasibility of a control population for a randomized control trial of seizure prophylaxis in the hypertensive disorders of pregnancy. ( Burrows, EA; Burrows, RF, 1995) |
| "Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains an important cause of maternal mortality." | 2.68 | Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. ( , 1995) |
| "Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents." | 2.65 | Buspirone: an anxioselective alternative for the management of anxiety disorders. ( Eison, AS; Eison, MS; Newton, RE; Riblet, LA; Taylor, DP; Temple, DL, 1983) |
| "On 2/3 of all occasions the seizure was interrupted in less than 15 min." | 2.65 | Diazepam rectal solution for home treatment of acute seizures in children. ( Hoppu, K; Santavuori, P, 1981) |
| "After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year." | 2.64 | Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. ( Knudsen, FU; Vestermark, S, 1978) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Most seizure emergencies occur outside of the hospital, and there is a need for treatment interventions that can be administered quickly and safely by nonclinical caregivers." | 2.52 | Intranasal therapies for acute seizures. ( Kälviäinen, R, 2015) |
| "Mean diazepam dose was 0." | 2.42 | The short-term outcome of seizure management by prehospital personnel: a comparison of two protocols. ( Bergholte, J; Galustyan, SG; Hennes, H; Szewczuga, D; Walsh-Kelly, CM, 2003) |
| "Falciparum malaria is the most common cause of convulsions in children admitted to hospital in malaria endemic areas." | 2.42 | Management of seizures in children with falciparum malaria. ( Newton, CR; Ogutu, BR, 2004) |
| " Subsequent replacement of hypertonic saline with normal saline and salt tabs in combination with phenytoin allowed gradual correction of serum sodium without any subsequent seizures or neurological complications." | 2.41 | Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature. ( Tokeshi, J; Youn, KS, 2002) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Subtle seizures are mild paroxysmal alterations in motor or autonomic activity and are unique to the neonatal period." | 2.41 | Seizures in the newborn. ( Aggarwal, R; Deorari, AK; Paul, VK; Upadhyay, A, 2001) |
| "Fosphenytoin has recently been approved as a substitute for parenteral phenytoin." | 2.40 | New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Acute repetitive seizures, also known as cluster or serial seizures, may present considerable health risks, including death, to patients with epilepsy and often are a cause of psychosocial stigma." | 2.40 | New therapies in the management of acute or cluster seizures and seizure emergencies. ( Shafer, PO, 1999) |
| "Buflomedil is a rheological agent largely used as a vasodilator in some European countries." | 2.39 | Acute buflomedil intoxication: a life-threatening condition. ( Alberti, A; Del Monte, D; Gallo, F; Petolillo, M; Valenti, S, 1994) |
| "Isoniazid has a low therapeutic margin and produces life threatening signs in dogs ingesting single 300 mg human tablets." | 2.39 | Treatment of acute isoniazid overdose in dogs. ( Barret, GH; Buck, WB; Holding, J; Knight, MK; Villar, D, 1995) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| "Status epilepticus is a medical emergency that requires rapid seizure control." | 2.37 | Constant diazepam infusion in the treatment of continuous seizure activity. ( Bell, HE; Bertino, JS, 1984) |
| "Febrile seizures are common in children." | 2.37 | The child with febrile seizures. ( Wright, SW, 1987) |
| "Febrile seizures are a common problem." | 2.37 | Febrile seizures: emergency department diagnosis and treatment. ( Ater, SB; Bettis, DB, 1985) |
| "1-Kynurenine is suggested to be an anxiogenic and convulsigenic endogenous factor." | 2.36 | Structure-activity relationships in kynurenine, diazepam and some putative endogenous ligands of the benzodiazepine receptors. ( Lapin, IP, 1983) |
| "Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
| " Bases for selection include: (1) availability of other than oral dosage forms; (2) differences in additive effect with alcohol in producing central nervous system depression; (3) differences in anticonvulsant effect; and (4) differences in duration of effect in the body (ie, half-life)." | 2.36 | Selection among benzodiazepines for alcohol withdrawal. ( Keeler, MH; Miller, WC, 1977) |
| " Following that, mice were intraperitoneally given a single convulsive dosage of PTZ (60 mg/kg) and then monitored for 30 min for symptoms of seizures." | 1.91 | Neuroprotective anticonvulsant and anxiolytic effects of octreotide in wistar rats. ( Abdolmaleki, A; Asadi, A; Hassanpour, H; Shayan, TK, 2023) |
| "Only diazepam significantly increased seizure freedom." | 1.72 | Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs. ( Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS, 2022) |
| " The first, a long-term, repeat-dose safety study of diazepam nasal spray, compared rates of treatment-emergent adverse events (TEAEs), serious TEAEs, and treatment-related TEAEs for patients receiving ≥1 second dose ≤4 h versus all second doses >4 h after the first." | 1.72 | Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis. ( Carrazana, E; Cascino, GD; Desai, J; Hogan, RE; Misra, SN; Rabinowicz, AL; Samara, E; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2022) |
| "Epilepsy is a common neurological disorder which affects 50 million people worldwide." | 1.72 | Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM, 2022) |
| "Beyond effectiveness for aborting seizure clusters, no data exist on how intermittent rescue therapy may impact the long-term natural course of seizure clusters." | 1.72 | Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. ( Carrazana, E; Davis, C; Misra, SN; Peters, JM; Rabinowicz, AL; Rao, VR; Sperling, MR, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "Caffeine is a psychoactive substance used worldwide." | 1.72 | Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. ( Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR, 2022) |
| "The fact that inflammation triggers epileptic seizures brings to mind the antiepileptic properties of anti-inflammatory drugs." | 1.72 | The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats. ( Çelik, H; Çetinkaya, A; Torun, İE; Türel, CA; Türel, İ, 2022) |
| "oleracea (LEO) on PTZ-induced seizures, using juvenile Colossoma macropomum fish (9." | 1.62 | Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum. ( Barbas, LAL; da Silva, TVN; Hamoy, M; Monserrat, JM; Sampaio, LA; Torres, MF, 2021) |
| "This study examined childhood seizure treatment in a rural area in Japan." | 1.62 | Initial treatment of seizures in children in an emergency department in rural Japan. ( Ando, H; Kido, S; Kidokoro, H; Natsume, J; Shiraki, A; Takahashi, Y; Yasui, M, 2021) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| " However, social acceptability and consistent bioavailability present limitations." | 1.62 | Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters. ( Carrazana, E; Cloyd, J; Haut, S; Rabinowicz, AL, 2021) |
| " Safety profile was consistent with diazepam rectal gel; no patient discontinued owing to treatment-emergent adverse events." | 1.62 | Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: Results from an exit survey of a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cook, DF; Guerra, C; Hogan, RE; Penovich, P; Rabinowicz, AL; Wheless, JW, 2021) |
| "Benzodiazepines are the mainstay of seizure rescue medication; for decades, rectally administered diazepam was the only approved rescue medication for seizure clusters outside the hospital setting." | 1.62 | Managing Acute Seizures: New Rescue Delivery Option and Resources to Assist School Nurses. ( Bougher, G; Brooks, L; Dean, P; O'Hara, K; Santilli, N; Shinnar, R, 2021) |
| "The latency and duration of induced convulsion, as well as mortality protection percentage were recorded 30 min after PTZ injection." | 1.62 | Effects of probiotics on pentylenetetrazol-induced convulsions in mice. ( Kangi, S; Najimi, S; Rahimi, HR; Sabouri, S, 2021) |
| "The few in-ED seizures occurred before medication administration." | 1.56 | Lorazepam Versus Diazepam in the Management of Emergency Department Patients With Alcohol Withdrawal. ( Barbic, D; Chiu, I; Duley, S; Grafstein, E; Grunau, B; Innes, G; Kestler, A; Lane, DJ; Miles, I; Moe, J; Nolan, S; Scheuermeyer, FX; Slaunwhite, A; Sljivic, I; Ti, L; Yan, A, 2020) |
| "In contrast, the same ES inhibited EEG seizures when delivered after a combination of DIA‑1." | 1.56 | Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats. ( Godlevsky, LS; Pervak, MP; Shandra, AA; Shandra, OO, 2020) |
| "Taurine (TAU) is an amino sulfonic acid which acts an endogenous inhibitory neuromodulator." | 1.51 | Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish. ( Barbosa, NV; Canzian, J; Dos Santos, MM; Fontana, BD; Loro, VL; Mello, CF; Mezzomo, NJ; Müller, TE; Rosemberg, DB; Ziani, PR, 2019) |
| " This study is aimed to evaluate the ability of DDS, alone or in combination with DZP starting their administration once the SE is onset to evaluate the control of seizures in rats." | 1.51 | Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats. ( Baron-Flores, V; Caballero-Chacón, S; Díaz-Ruiz, A; Farfán-Briseño, AC; Franco-Pérez, J; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Nava-Ruiz, C; Ríos, C; Ruiz-Diaz, A, 2019) |
| "Cessation of seizure was achieved in 85% of the adults and in 97% of the children, if all options of the MTAS-EMS were used." | 1.51 | Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis. ( Baulig, W; Dette-Oltmann, K; Mariotti, S; Schenk, P; Theusinger, OM, 2019) |
| " These data are important for informing adult and pediatric dosing recommendations for NA-induced seizures." | 1.51 | Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats. ( Ardinger, C; Dunn, E; Haines, K; Lee-Stubbs, R; Matson, L; McCarren, H; McDonough, J; Miller-Smith, S; Whitten, K, 2019) |
| "Diazepam treatment significantly reduced cumulative seizure behaviors by 79% compared to saline-treated animals but offered no cardiac protection." | 1.48 | Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure. ( Harrison, JC; Kerr, DS; McCann, DM; Millen, RN; Read, MI; Sammut, IA, 2018) |
| "Seizures affect about 50 million people around the world." | 1.48 | Clarified Açaí ( ( Arrifano, GPF; Carvalho, JCT; Crespo-López, ME; Farina, M; Lichtenstein, MP; Rogez, H; Souza-Monteiro, JR; Suñol, C, 2018) |
| "Organophosphate (OP) induced seizures are commonly treated with anticholinergics, oximes and anticonvulsants." | 1.48 | Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar. ( Cornelissen, AS; Hesseling, P; Joosen, MJA; Klaassen, SD; Lucassen, PJ; Meerhoff, GF; Vester, SM, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 1.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "She had no recurrence of seizures but had acute liver injury subsequently which gradually improved with supportive care." | 1.46 | Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report. ( Dilrukshi, MDSA; Gnanathasan, CA; Ratnayake, CAP, 2017) |
| "Carbamazepine was significantly more efficacious than diazepam suppositories in the aFc group (odds ratio = 49." | 1.46 | Clinical Epidemiology and Treatment of Febrile and Afebrile Convulsions With Mild Gastroenteritis: A Multicenter Study. ( Higuchi, Y; Horibe, K; Ichimi, R; Iguchi, K; Kamimaki, I; Koga, H; Komiyama, O; Kubo, T; Mitsuhashi, T; Miyagawa, S; Nakamura, N; Saito, A; Shukuya, A; Takayanagi, T; Tanaka, S; Uchida, Y; Watanabe, K; Yamamoto, S; Yamashita, H; Yokota, I, 2017) |
| "The increased catamenial seizure exacerbation and alterations in antiseizure drug responses are consistent with NSW-induced changes in the abundance of δGABA-A receptors." | 1.46 | Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain. ( Clossen, BL; Reddy, DS, 2017) |
| "We observed increased latency of tonic-clonic seizures that was inversely proportional to the dose of MRE, with a similar impact on the lethal effects of pentylenetetrazol." | 1.43 | Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in mice: A comparison to diazepam. ( Hernández-Medel, Mdel R; Mora-Pérez, A, 2016) |
| "Febrile seizures are the most common type of convulsive events in children." | 1.43 | Forebrain-independent generation of hyperthermic convulsions in infant rats. ( Blumberg, MS; Kaila, K; Pospelov, AS; Puskarjov, M; Yukin, AY, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| " Medication dosage was initially higher using the HAES, so that the time needed to monitor withdrawal symptoms could be reduced (3." | 1.43 | [Comparison of Two Symptom-Triggered Treatments for Alcohol Withdrawal: HAES vs. SAB-P]. ( Holzbach, R; Ihlow, C; Kemper, U; Naber, D; Takla, T, 2016) |
| "Diazepam treatment at 6 h immediately stopped the seizures and prevented animal death." | 1.43 | Characterization of seizures induced by acute exposure to an organophosphate herbicide, glufosinate-ammonium. ( Ardourel, MY; Calas, AG; Herzine, A; Lauga, F; Menuet, A; Montécot-Dubourg, C; Mortaud, S; Palomo, J; Pâris, A; Perche, A; Perche, O; Pichon, J; Richard, O, 2016) |
| "• For seizures with duration of more than 5 min, the administration of anticonvulsive rescue medication is recommended." | 1.43 | Administration of anticonvulsive rescue medication in children-discrepancies between parents' self-reports and limited practical performance. ( Bernhard, MK; Bertsche, A; Bertsche, T; Frontini, R; Hoppe, SC; Kaune, A; Kiess, W; Merkenschlager, A; Neininger, MP; Schumacher, PM; Syrbe, S, 2016) |
| "Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems." | 1.43 | Local Anesthetics Systemic Toxicity. ( Jayanthi, R; Monica, K; Nasser, K, 2016) |
| "Diazepam was used as reference anticonvulsant drug." | 1.42 | Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. ( FallahHuseini, H; Ghaznavi, H; Gholamine, B; Hosseinzadeh, A; Mehrzadi, S; Sadr, S; Shahbazi, A, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "Treatment-resistant seizures affect about a third of patients suffering from epilepsy." | 1.42 | Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. ( Afrikanova, T; Buenafe, OE; Crawford, AD; De Prins, A; de Witte, PA; Esguerra, CV; Kaminski, RM; Langlois, M; Leclercq, K; Rospo, CC; Smolders, I; Van Eeckhaut, A, 2015) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker." | 1.42 | Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. ( Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST, 2015) |
| "Four uncommon cases of canine distemper (CD) were diagnosed in vaccinated adult dogs." | 1.40 | Uncommon acute neurologic presentation of canine distemper in 4 adult dogs. ( Carletti, BE; de las Mulas, JM; Galán, A; Gamito, A; Guisado, A; Martín, EM; Pérez, J, 2014) |
| "Current treatments for seizure emergencies, such as status epilepticus, include intravenous or rectal administration of benzodiazepines." | 1.40 | Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies. ( Georg, GI; Kapoor, M; Lis, L; Siegel, RA; Winter, T, 2014) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote." | 1.40 | Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. ( Austin, AT; Banks, CN; Bruun, DA; Hammock, BD; Inceoglu, B; Lein, PJ; Rogawski, MA; Tancredi, DJ; Vito, ST; Zolkowska, D, 2014) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 1.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| "Seizures were analyzed using the Lamberty & Klitgaard score and kindling was considered as established after at least three consecutive seizures of score 4 or 5." | 1.39 | Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats. ( Beleboni, RO; Cunha, AO; Dos Santos, WF; Gelfuso, EA; Liberato, JL; Lopes, NP; Mortari, MR, 2013) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "In children, convulsive seizures lasting-more than 5 minutes constitute a life-threatening condition." | 1.39 | Midazolam oral transmucosal route. An alternative to rectal diazepam for some children. ( , 2013) |
| "A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries." | 1.39 | Feasibility study of a caregiver seizure alert system in canine epilepsy. ( Cloyd, JC; Coles, LD; Higgins, J; Leyde, K; Litt, B; Mavoori, J; Michael, B; Patterson, EE; Sheffield, WD; Vite, C; Worrell, GA, 2013) |
| "Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures." | 1.39 | Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. ( Baraban, SC; Dinday, MT; Hortopan, GA, 2013) |
| "However, the effects of the seizures, as well as possible treatment strategies, have yet to be elucidated, particularly in juvenile or insulin-dependent diabetes mellitus (IDDM)." | 1.39 | Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality. ( Carlen, PL; del Campo, M; El-Hayek, Y; Giacca, A; Hazrati, L; Maheandiran, M; Mylvaganam, S; Sugumar, S; Wu, C; Zhang, L, 2013) |
| "Melatonin has been mainly used for alleviating some disorders related with insomnia and circadian rhythmicity." | 1.39 | Behavioural actions of two new 1-N substituted analogues of melatonin. ( Bustamante-García, R; Lira-Rocha, AS; Naranjo-Rodríguez, EB; Ortiz-Osornio, A; Picazo, O, 2013) |
| "Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of γ-aminobutyric acid A (GABA(A)) receptors." | 1.38 | The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: synergism with the benzodiazepine diazepam. ( Kelley, NR; Lee, RB; Lumley, LA; Moffett, MC; Schultz, MK; Schwartz, JE; Stone, MF; Wright, LK, 2012) |
| "Diazepam (10mg/kg) was administered 10min and 30min after the onset of continuous EEG seizures induced by paraoxon and it terminated SE in a majority of animals at both time points." | 1.38 | Characterization of status epilepticus induced by two organophosphates in rats. ( Balint, CA; Cowan, ML; Kapur, J; Sun, C; Todorovic, MS, 2012) |
| "Seizures were significantly increased in rats receiving 80% and 120% of citalopram MLD versus controls (p<0." | 1.38 | Mechanisms of high-dose citalopram-induced death in a rat model. ( Baud, FJ; Beaune, S; Callebert, J; Juvin, P; Mégarbane, B; Risède, P, 2012) |
| " Repeated benzodiazepine dosing or combined application of benzodiazepines and NMDA receptor antagonists is more likely to be effective in treating TMDT poisoning." | 1.38 | Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors. ( Shakarjian, MP; Stanton, PK; Velíšek, L; Velíšková, J, 2012) |
| "In 93 (77." | 1.38 | Ecalmpsia: maternal and fetal outcome. ( Jido, TA, 2012) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i." | 1.38 | Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. ( Mori, T; Shibasaki, M; Shimizu, N; Suzuki, T, 2012) |
| "Temporal lobe epilepsy is prevalent and can be difficult to treat effectively." | 1.37 | Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Lew, FH, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| " A reduction in the dosage of benzodiazepines in the setting of epileptic patients with predominant autonomic symptoms may need to be considered." | 1.37 | Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications! ( Fluss, J; Gervaix, A; Korff, CM; Lacroix, L, 2011) |
| "Recurrent seizure activity has been shown to induce a variety of permanent structural changes in the brain." | 1.37 | Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. ( Ibi, D; Itohara, S; Kamei, H; Koike, H; Mizoguchi, H; Nabeshima, T; Nakade, J; Sato, J; Sawada, M; Someya, E; Tachibana, M; Takuma, K; Yamada, K, 2011) |
| "Imidazenil is an imidazo-benzodiazepine derivative with high intrinsic efficacy and selectivity for α2-, α3-, and α5- but low intrinsic efficacy for α1-containing GABA(A) receptors." | 1.37 | Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage. ( Auta, J; Davis, JM; Gocel, J; Guidotti, A; Kadriu, B; Larson, J; Nambiar, MP, 2011) |
| "He also had visual hallucinations and temporary high blood pressure." | 1.37 | Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report. ( Kato, S; Kobayashi, T; Saito, N; Shioda, K; Suda, S, 2011) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| "All samples reduced SMA and inhibited catalepsy." | 1.36 | Ayurvedic processed seeds of nux-vomica: neuropharmacological and chemical evaluation. ( Bhattacharya, SK; Katiyar, C; Kumar, A; Singh, RS, 2010) |
| "Scopoletin which was identified as the major constituent of the extract was found to be an inhibitor of GABA-T (IC50=10." | 1.36 | Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. ( Ahmad, S; Akhtar, M; Basu, A; Basu, M; Dev, A; Jayaprakash, V; Mishra, N; Oraon, A; Pattnaik, AK; Swaroop, S; Tripapthi, SN, 2010) |
| "The latency for development of convulsions and mortality rate was recorded in these models using mice." | 1.36 | Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. ( Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S, 2010) |
| "The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described." | 1.35 | Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. ( Cook, JM; Edwankar, CR; Edwankar, RV; Furtmüller, R; Huang, S; Jain, HD; Majumder, S; Murphree, L; Ramerstorfer, J; Rivas, FM; Roth, BL; Sankar, S; Sieghart, W; Stables, JP; Zhou, H, 2009) |
| "Diazepam was used as standard drug." | 1.35 | Synthesis of novel bioactive derivatives of 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-ones. ( Baheti, K; Bora, R; Chhabría, M; Dekhane, D; Gupta, SV; Pawar, S; Shingare, M; Shishoo, CJ; Thore, SN, 2009) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, fixed current intensity 35 mA, stimulus duration 0." | 1.35 | Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. ( Aziz Ahari, F; Motamedi, F; Naderi, N; Najarkolaei, AH; Shafaghi, B, 2008) |
| "Cocatropine toxicity was partially or fully reversed by diazepam (5 mg/kg), given intraperitoneally after the first seizure." | 1.35 | Diazepam protects against the enhanced toxicity of cocaine adulterated with atropine. ( Braida, D; Capurro, V; Gori, E; Pegorini, S; Rossoni, G; Sala, M; Zani, A, 2008) |
| "A timely and effective control of seizures with pharmacological agents can minimize the secondary and long-term neuropathology that may result from this damage." | 1.35 | Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. ( Auta, J; Costa, E; Guidotti, A; Kadriu, B, 2009) |
| "After repeated treatment the PTZ seizure threshold was not different between the two drugs, while differences in sedation became larger than after the acute treatment." | 1.35 | Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. ( Pericić, D; Vlainić, J, 2009) |
| "Diazepam (DIZ) was used as anticonvulsant." | 1.35 | A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice. ( Mustafa, AA; Salih, MA, 2008) |
| "This is a report of a jacksonian seizure in a non-psychotic manic patient who was treated with right prefrontal high frequency rTMS concomitant to pharmacotherapy." | 1.35 | Jacksonian seizure in a manic patient treated with rTMS. ( Papadimitriou, GN; Psarros, C; Sakkas, P; Soldatos, CR; Theleritis, CG, 2008) |
| "The dog was presented with seizures and neurological deficits consistent with a left brainstem and multifocal/diffuse forebrain lesion after an asymptomatic interval of 72 hours following the ischaemic event." | 1.35 | Sequential magnetic resonance imaging changes after suspected global brain ischaemia in a dog. ( Flegel, T; Oechtering, G; Timm, K, 2008) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 1.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "Toluene is a commonly abused inhalant." | 1.34 | Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats. ( Chan, MH; Chen, HH; Lin, YR; Liu, CL, 2007) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| "Diazepam prevents lidocaine-induced seizures, but not neuronal damage in brain structures." | 1.34 | Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats. ( Blas-Valdivia, V; Cano-Europa, E; Hernández-García, A; Ortiz-Butrón, R, 2007) |
| "When diazepam (1 mg/kg) was given 20 min prior to 5-min swim stress, or 24 h after 10-min swim stress, there was no significant change in its anticonvulsant activity between unstressed and swim stressed mice." | 1.34 | Interaction of diazepam and swim stress. ( Pericić, D; Strac, DS; Vlainić, J, 2007) |
| "Soman-intoxicated groups without seizures did not have an elevated cytokine level." | 1.33 | Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain. ( Cassel, G; Svensson, I; Waara, L, 2005) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 1.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "Rodent seizure models have significantly contributed to our basic understanding of epilepsy." | 1.33 | Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. ( Baier, H; Baraban, SC; Castro, PA; Taylor, MR, 2005) |
| "Preeclampsia is a complication of pregnancy associated with hypertension and proteinuria." | 1.33 | Late postpartum eclampsia as an obstetric complication seen in the ED. ( Graeber, B; Stiller, RJ; Vanderwal, T; Werdmann, MJ, 2005) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "Diazepam treatment alone and before cocaine overdose did not interfere with catalase activity." | 1.33 | Cocaine alters catalase activity in prefrontal cortex and striatum of mice. ( Aguiar, LM; de Sousa, FC; de Vasconcelos, SM; dos Santos, RS; Lima, VT; Macêdo, DS; Viana, GS, 2005) |
| "Diazepam was administered as the first-line drug on 157 of 177 occasions (88." | 1.33 | [Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children]. ( Eto, Y; Hamano, S; Hayakawa, M; Kikuchi, K; Minamitani, M; Sugiyama, N; Tanaka, M; Yamashita, S; Yoshinari, S, 2005) |
| "Increased seizure duration [3,522 +/- 660 sec (SEM) vs." | 1.33 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. ( Allan, SM; Davies, RE; Heenan, LE; Patel, HC; Ross, FM; Rothwell, NJ, 2006) |
| "Onset, duration of clonic convulsions and percentage mortality/recovery were recorded." | 1.33 | Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2006) |
| "Posterior reversible encephalopathy syndrome (PRES) is an acronym that identifies a new clinico-neuroradiologic entity occurring in association with different conditions." | 1.33 | PRES: posterior or potentially reversible encephalopathy syndrome? ( Abbate, M; Ferlazzo, E; Granata, F; Mazzù, I; Musolino, R; Narbone, MC, 2006) |
| "Latency and incidence of a clonic seizure were recorded." | 1.32 | Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors. ( Ahmadiani, A; Mandgary, A; Sayyah, M, 2003) |
| "When diazepam was administered together with atropine, seizures were not observed but 62." | 1.32 | Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose. ( Breton, P; Buée, J; Calvet, JH; Christin, D; Delamanche, S; Taysse, L, 2003) |
| "Numbers of ictal events (seizure) and latency to the first event were reduced by prophylactic DZP." | 1.32 | Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. ( Anschel, DJ; Fisher, RS; Ortega, E, 2004) |
| "In PTZ-induced seizure, the intraperitoneally injection of thymoquinone with doses of 40 and 80 mg/kg, prolonged the onset of seizures and reduced the duration of myoclonic seizures." | 1.32 | Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. ( Hosseinzadeh, H; Parvardeh, S, 2004) |
| "Convulsions are major and life-threatening signs of organophosphate (OP) nerve agents induced neurotoxicity." | 1.32 | Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. ( Auta, J; Costa, E; Davis, J; Guidotti, A, 2004) |
| "The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode." | 1.32 | Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. ( Negoro, T; Okumura, A; Uemura, N; Watanabe, K, 2004) |
| "We refined and developed models of seizure-induced neuronal death in the C57BL/6 and BALB/c strains by focally evoking seizures using intra-amygdala kainic acid." | 1.32 | Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. ( Araki, T; Henshall, DC; Lan, JQ; Schindler, CK; Shinoda, S; Simon, RP; Taki, W, 2004) |
| " Hence, in the present study, its (100 and 200 mg/kg) action was tested alone and in combination with phenobarbitone (20 mg/kg) and diazepam (0." | 1.32 | Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats. ( Ekambaram, P; Paul, V, 2003) |
| "Brief limbic seizures were evoked by intraamygdala kainic acid to elicit unilateral death of target hippocampal CA3 neurons in the rat." | 1.31 | Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. ( Araki, T; Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Minami, M; Schindler, CK; Simon, RP; Skradski, SL, 2002) |
| "In animals that displayed seizures and convulsions, diazepam (5 mg/kg, i." | 1.31 | Pharmacological antagonism of lethal effects induced by O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate. ( Chang, FC; DeBus, S; Hoffman, BE, 2002) |
| "The lack of effect on seizures induced by picrotoxin suggests that the action of ivermectin is different from that of the benzodiazepine drugs." | 1.31 | Possible anxiolytic effects of ivermectin in rats. ( Bernardi, MM; Spinosa, Hde S; Stilck, SR, 2002) |
| "The incidence of respiratory depression following treatment of prolonged seizures with benzodiazepines is variable in the literature." | 1.31 | Respiratory depression in the acute management of seizures. ( Dooley, JM; Harrison, R; Stewart, WA, 2002) |
| "Postoperative epileptic seizures are recognised but rare." | 1.31 | Postoperative pseudostatus: not everything that shakes is epilepsy. ( Enright, SM; Goulding, PJ; Reuber, M, 2000) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 1.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "Sensitivity to PTZ-induced seizures and lethality was not affected in mice with a history of repeated treatment with ganaxolone, diazepam, or valproate." | 1.31 | Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. ( Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM, 2000) |
| "Diazepam was used as a reference drug." | 1.31 | The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. ( Chojnacka-Wójcik, E; Przegaliński, E; Tatarczyńska, E, 2000) |
| "Gabapentin has been shown to reduce paired-pulse inhibition in the dentate gyrus of the urethane-anesthetized rat and has been shown to block calcium channels, but its not known how these possible mechanisms relate to its antiepileptic effect." | 1.31 | The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine. ( Stringer, JL; Taylor, CP, 2000) |
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| "Refractory seizures not responding to benzodiazepine may require an antiepileptic drug." | 1.31 | Chloroquine poisoning: report of two cases. ( Reddy, VG; Sinna, S, 2000) |
| "However, the attenuation of severe seizures by a single PRA, PHEN, DZP, or PHB cotreatment was accompanied by a decrease in the brain COCA concentration." | 1.31 | Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity. ( Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y, 2000) |
| "These compounds induced convulsions, urination and defecation in mice." | 1.31 | Neuropharmacological actions of some binuclear lanthanide(III) complexes. ( Howell, RC; Kahwa, IA; Williams, LA; Young, R, 2001) |
| "Seizures were elicited by microinjection of kainic acid into the amygdala of the rat and terminated after 40 min by diazepam." | 1.31 | Caspase-2 activation is redundant during seizure-induced neuronal death. ( Bonislawski, DP; Henshall, DC; Lan, JQ; Simon, RP; Skradski, SL, 2001) |
| "All rats had stage 5 convulsions 24 hr after cessation of the administration of dipotassium clorazepate and diazepam." | 1.31 | Differences between the tolerance characteristics of two anticonvulsant benzodiazepines in the amygdaloid-kindled rat. ( Amano, K; Deshimaru, M; Katsuragi, S; Miyakawa, T; Miyazaki, C; Ogata, A; Takamatsu, J, 2001) |
| "A partial but significant inhibition of convulsions was found in these animals." | 1.31 | Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam. ( Jayakumar, AR; Vanaja, P, 2001) |
| "The interval until convulsion due to picrotoxin was also prolonged by the administration of DMP combined with diazepam and valproic acid (VPA)." | 1.31 | Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain. ( Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K, 2001) |
| "Seizures are commonly associated with hypoxic-ischemic encephalopathy." | 1.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| "Diazepam is used to terminate convulsions but its pharmacokinetics and pharmacodynamics have not been studied in this group." | 1.31 | Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions. ( Crawley, J; Edwards, G; Kokwaro, GO; Marsh, K; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO, 2002) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 1.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "Diazepam was administered to rabbits using both the i." | 1.31 | Intracavernous application of diazepam: an alternative route of the seizure treatment--an experimental study in rabbits. ( DeGim, T; Denli, M; Dündaröz, R; Gökçay, E; Sizlan, A; Yaşar, M, 2002) |
| " Pharmacokinetic analysis of several compounds indicated excellent oral bioavailability and a reasonable half-life in rats." | 1.30 | Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. ( Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ, 1999) |
| "Flumazenil failed to affect seizure thresholds for bicuculline either in handling stressed or in swim stressed animals." | 1.30 | Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites. ( Bujas, M; Pericić, D, 1997) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "Patients with epileptic and nonepileptic seizures are commonly encountered in clinical practice, and they can pose a difficult diagnostic problem." | 1.30 | Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures. ( Blend, MJ; de León, OA; Gaviria, M; Jobe, TH; Lin, Q; Sychra, JJ, 1997) |
| " It was reported to potentiate GABA-mediated chloride current in cultured cells with a moderate intrinsic activity and a biphasic dose-response relationship." | 1.30 | Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor. ( Carter, DB; Franklin, SR; Jacobsen, EJ; Needham, LM; Sethy, VH; Tang, AH; Von Voigtlander, PF, 1997) |
| "We conclude that the prolonged seizures of status epilepticus rapidly altered the functional properties of hippocampal dentate granule cell GABARs." | 1.30 | Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. ( Kapur, J; Macdonald, RL, 1997) |
| " FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
| "Gastroenteritis has been reported in association with a variety of other disease conditions, such as respiratory infections and CNS involvement." | 1.30 | [Afebrile seizures in rotavirus gastroenteritis]. ( Alvarez, K; Lacitignola, L; Materassi, D; Repetto, T, 1997) |
| "The increase in seizure sensitivity of repeatedly withdrawn mice was prevented by treatment with the NMDA receptor antagonist CGP 39551 (20 mg/kg, i." | 1.30 | Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist. ( Dunworth, SJ; Stephens, DN, 1998) |
| "The decrease in the seizure threshold for pentylenetetrazole in diazepam-withdrawn mice was not significantly affected by L-arginine (50 and 100 microg/mouse, i." | 1.30 | Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice. ( Misawa, M; Shimizu, N; Suzuki, T; Tsuda, M; Yajima, Y, 1998) |
| "Two pharmacoeconomic studies on the treatment of acute seizures have been conducted." | 1.30 | Pharmacoeconomic considerations in treatment options for acute seizures. ( Graves, N, 1998) |
| "Bupivacaine is a commonly used local anesthetic in dental, ophthalmologic, and simple surgical procedures." | 1.30 | Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement. ( Newman, RD; Yan, AC, 1998) |
| "All children who presented in a convulsion, including convulsive status epilepticus, to the accident and emergency department over a 12-month period and who required treatment, were reviewed retrospectively to identify the effectiveness and safety of a specific treatment protocol." | 1.30 | Children presenting with convulsions (including status epilepticus) to a paediatric accident and emergency department: an audit of a treatment protocol. ( Appleton, RE; Garr, RE; Molyneux, EM; Robson, WJ, 1999) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i." | 1.30 | Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. ( Misawa, M; Shimizu, N; Soma, M; Suzuki, T; Tsuda, M, 1999) |
| "Gacyclidine was injected (i." | 1.30 | Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support. ( Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Lallement, G; Peoc'h, M, 1999) |
| "wt) had convulsion and it suppresses the NOS activity and NO concentration in brain regions." | 1.30 | Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action. ( Jayakumar, AR; Jayakumar, R; Paul, V; Puviarasan, K; Sujatha, R, 1999) |
| "However, both the compounds suppressed convulsions elicited by ammonium chloride." | 1.30 | Independent and combined effects of L-arginine and diazepam on ammonium chloride-induced convulsions in rats. ( Jayakumar, AR; Paul, V, 1999) |
| "Potentially life-threatening seizures can occur following withdrawal from benzodiazepines, ethanol, or barbiturates." | 1.30 | Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital. ( Crabbe, JC; Metten, P, 1999) |
| " The features of the stimulant-induced seizures were distinct and included the following: (1) the duration of convulsive activity was shortest for cocaine and longest for methamphetamine, (2) only MDMA produced a secondary clonic phase after the initial ictal event, and (3) 4-methylaminorex manifested a very steep dose-response curve." | 1.30 | Distinct features of seizures induced by cocaine and amphetamine analogs. ( Hanson, GR; Jensen, M; Johnson, M; White, HS, 1999) |
| "Treatment with diazepam (25 mg/kg; p." | 1.30 | Abecarnil enhances recovery from diazepam tolerance. ( Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A, 1999) |
| "Seizures are a frequent problem confronting EMS personnel." | 1.30 | Prehospital management of the seizure patient. ( Nicholl, JS, 1999) |
| "Medical records were reviewed for seizure and medication history, diagnostic test results, types of treatment, hospitalization costs, and outcome of hospital visits." | 1.30 | Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995). ( Bateman, SW; Parent, JM, 1999) |
| " DZP and HAL dose-response curves (0, 0." | 1.30 | Effects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex. ( de Oliveira, RW; Gomes, CF; Nakamura-Palacios, EM, 1999) |
| "A partial but significant inhibition of convulsion responses was found in these animals." | 1.30 | Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats. ( Jayakumar, AR; Paul, V, 1999) |
| "Myoclonic, clonic and tonic seizures were induced by i." | 1.29 | Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil. ( Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P, 1995) |
| "The kainate-elicited convulsions and NO formation were attenuated in animals pretreated with either 7-nitroindazole, a specific inhibitor of neuronal NO synthase, or diazepam." | 1.29 | Nitric oxide promotes seizure activity in kainate-treated rats. ( Busse, R; Mordvintcev, PI; Mülsch, A; Nielsen, EO; Olesen, SP; Scheel-Krüger, J; Vanin, AF, 1994) |
| " The anticonvulsant profile of chronic administration of BR-16A (100 and 500 mg/kg) was studied in this model of epilepsy." | 1.29 | Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A. ( George, B; Kulkarni, SK, 1995) |
| "The minimal amount of seizure activity necessary for irreversible neural damage to become evident under these conditions is approximately 20 min, and the process accelerates greatly after this minimal time has elapsed." | 1.29 | Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. ( Dochterman, LW; McDonough, JH; Shih, TM; Smith, CD, 1995) |
| "Naloxone was ineffective in antagonizing the analgesic effect of Rhazya stricta on tail-flick and abdominal constriction tests, possibly indicating that this effect occurs via non-opiate pathways." | 1.29 | Central nervous system activity of Rhazya stricta (Decne) in mice. ( Ali, BH; Banna, NR; Bashir, AK; Tanira, MO, 1995) |
| "After baseline recordings, seizures were induced with a pentylenetetrazol (PTZ) bolus and a 20 min infusion (5-6 mg/kg/min)." | 1.29 | Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam. ( Fordyce, WE; Terndrup, TE, 1995) |
| "Pretreatment with diazepam (1." | 1.29 | Observations of novel behaviors as indices of ethanol withdrawal-induced anxiety. ( Knapp, DJ; Pohorecky, LA; Saiers, JA, 1993) |
| "The effects of chronic administration of aminophylline (AMPH; 50 mg/kg, twice daily for 14 consecutive days) were studied on both antielectroshock efficacy of diazepam (DZP) and convulsive activity of AMPH in mice." | 1.29 | Influence of chronic aminophylline on antielectroshock activity of diazepam and aminophylline-induced convulsions in mice. ( Czuczwar, SJ; Kleinrok, Z; Roliński, Z; Wlaź, P, 1994) |
| "These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity." | 1.29 | Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice. ( Crabbe, JC; Keith, LD; Roberts, AJ, 1994) |
| "1." | 1.29 | Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil. ( Hönack, D; Löscher, W, 1994) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| "When flumazenil or ZK 93426 was given to diazepam tolerant mice, this reversal was complete." | 1.29 | A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice. ( Kapetanovic, IM; Kupferberg, HJ; Torchin, CD, 1993) |
| "Rats treated with diazepam for 3 weeks were tolerant to diazepam, clonazepam, clobazam, and midazolam." | 1.29 | Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam. ( Ramsey-Williams, VA; Rosenberg, HC; Wu, Y, 1994) |
| " Results show that as the dosage of SCP increased, the mean toxicity scores decreased." | 1.29 | Efficacy comparison of scopolamine and diazepam against soman-induced debilitation in guinea pigs. ( Anderson, DR; Bowersox, SL; Carter, WH; Gennings, C; Harris, LW; Lennox, WJ; Solana, RP, 1994) |
| " BIP and SCP were effective over dosage ranges between 10 and 0." | 1.29 | Efficacy of injectable anticholinergic drugs against soman-induced convulsive/subconvulsive activity. ( Anders, JC; Anderson, DR; Bowersox, SL; Harris, LW; Lennox, WJ, 1994) |
| "Two patients developed seizure immediately after flumazenil administration that aimed to reverse the prolonged sedative effect of diazepam." | 1.29 | Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases. ( Hseu, SS; Hsing, CH; Lee, TY; Ng, KO; Tang, GJ, 1994) |
| "Diazepam was used as a reference." | 1.29 | Long-term treatment with abecarnil does not induce diazepam-like dependence in mice. ( Schneider, HH; Stephens, DN; Steppuhn, KG; Turski, L, 1993) |
| "The effects of electroconvulsive seizure and anti-convulsant drugs on induction of mRNA of heat shock protein were studied in mouse brain." | 1.29 | Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain. ( Abe, K; Kaneko, M; Kogure, K; Matsuki, N; Saito, H, 1993) |
| "Since repeated seizures and a number of pharmacological agents are known to alter the onset and duration of seizure activity, a relationship between the changes in excitability and the onset of the seizure activity was tested using MK-801, ketamine, bicuculline, diazepam, phenobarbital, baclofen and repeated seizures." | 1.29 | Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus. ( Stringer, JL, 1993) |
| " These observations indicated that 5-HT3 receptor antagonists are ineffective in attenuating hyperlocomotor activity following abrupt termination of chronic administration of ethanol or diazepam, and increased sensitivity to PTZ in the ethanol-withdrawn rats." | 1.29 | Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation. ( Mehta, AK; Ticku, MK, 1993) |
| " In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min." | 1.29 | Pharmacological modulation of soman-induced seizures. ( McDonough, JH; Shih, TM, 1993) |
| "Abecarnil was able to antagonize the convulsions elicited by isoniazid in diazepam-tolerant mice." | 1.29 | Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam. ( Biggio, G; Ghiani, CA; Motzo, C; Porceddu, ML; Serra, M, 1995) |
| "The probability of seizure activity during these four withdrawal episodes was calculated as 0." | 1.29 | Diazepam prevents progression of kindled alcohol withdrawal behaviour. ( Allerup, P; Bech, B; Hemmingsen, R; Ulrichsen, J, 1995) |
| " Development of anticonvulsant tolerance and benzodiazepine (BZD) receptor down-regulation has been reported to occur upon chronic administration of conventional BZDs." | 1.29 | Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats. ( Contarino, A; Giusti, P; Lipartiti, M; Mariot, R; Zanotti, A, 1996) |
| "The majority (86." | 1.29 | Eclampsia--are we doing enough? ( Low, JJ; Yeo, GS, 1995) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| "Development of tolerance and dependence has been reported to occur upon chronic administration of traditional benzodiazepines (BZDs)." | 1.29 | Abecarnil, a beta-carboline derivative, does not exhibit anticonvulsant tolerance or withdrawal effects in mice. ( Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A, 1996) |
| "Electroencephalographic (EEG) seizures, grouped and isolated spikes, and significant increases of multineuronal activity (MUA) were elicited by fentanyl, 50 micrograms/kg iv, in these brain structures." | 1.29 | Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gómez, A; Ruelas, R, 1996) |
| "Pretreatment with diazepam alone increased both cumulative convulsant doses and plasma concentrations of lidocaine at the onset of convulsions." | 1.28 | Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats. ( Arakawa, K; Benson, KT; Goto, H; Yokoyama, M, 1992) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 1.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 1.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| "Withdrawal Seizure Prone (WSP) mice, genetically selected to develop severe handling-induced convulsions after withdrawal from chronic ethanol treatment, were exposed to ethanol vapor for 24 h." | 1.28 | Antagonism of ethanol withdrawal convulsions in Withdrawal Seizure Prone mice by diazepam and abecarnil. ( Crabbe, JC, 1992) |
| "The effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, were studied in mice." | 1.28 | [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice]. ( Ally, A; Hara, Y; Murayama, S; Suzuki, T, 1992) |
| " Another group of 100 age matched children with convulsions, along with those who did not respond to rectal therapy were given intravenous diazepam in a dosage of 0." | 1.28 | Per rectal diazepam therapy in convulsive disorders. ( Chaturvedi, N; Dube, KN; Kalra, A; Kalra, K; Vashishtha, VM, 1992) |
| "A series of 5 generalized tonic-clonic seizures within 30 min was induced by repeated transauricular electrical stimulation in mice." | 1.28 | Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin. ( Hönack, D; Löscher, W, 1992) |
| "The PTZ seizure threshold determined in various rabbit groups during the control phase of conducted experiments, was found to be in the range of 10." | 1.28 | The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit. ( al-Hader, A; Hasan, M; Hasan, Z, 1992) |
| "Although seizures and encephalopathic syndrome have been described with DEET in previous case reports involving topical exposure of pediatric patients, atypical aspects with regard to this case include that this patient was a male (most other case reports involve females), exposure was relatively brief compared with other reports, and the patient developed seizures without a prodrome described in previous reports." | 1.28 | Seizure following brief exposure to the insect repellent N,N-diethyl-m-toluamide. ( Kramer, JE; Leikin, JB; Lipscomb, JW, 1992) |
| "Diazepam was antagonized by the benzodiazepine inverse agonists and by the neutral antagonist." | 1.28 | In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole. ( Ashton, D; Clincke, GH; Fransen, J; Heeres, J; Janssen, PA, 1992) |
| " Buflomedil at a dosage of 50 mg/kg weight produces seizures." | 1.28 | Buflomedil intoxication: the little-known risk. ( Lara, B; Martínez-Sierra, R; Torres, A, 1992) |
| "Kynurenine is a direct precursor of kynurenic acid, the only known endogenous antagonist of excitatory amino acid receptors in the brain." | 1.28 | Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain. ( Beal, MF; MacGarvey, U; Miller, J; Vécsei, L, 1992) |
| "Seizures were repetitive and death occurred in 10." | 1.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| "Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1." | 1.28 | Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex. ( Bitran, D; Kellogg, CK; Primus, RJ, 1991) |
| "Flumazenil did not produce any significant pharmacological effect." | 1.28 | In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates. ( Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M, 1991) |
| "For PTZ-induced convulsions, DN-2327, 0." | 1.28 | Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents. ( Fukuda, N; Wada, T, 1991) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 1.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| "Spinal cord seizures are infrequently reported." | 1.28 | Spinal cord seizures: a possible cause of isolated myoclonic activity in traumatic spinal cord injury: case report. ( Cross, LL; Meythaler, JM; Tuel, SM, 1991) |
| " These results, when compared with human pharmacokinetic studies, allow a means of extrapolating effective monkey anticonvulsant doses to humans on a pharmacokinetic basis." | 1.28 | Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. ( Corcoran, KD; Lukey, BJ; Solana, RP, 1991) |
| "The majority of non-seizure sites showed no effects of diazepam upon period threshold." | 1.28 | Diazepam alters brain-stimulation reward thresholds in seizure-prone sites. ( Bielajew, C; Harris, T, 1991) |
| "Time to first convulsion and time to death were recorded over the next 7 h and all groups were monitored over the next 7 days." | 1.28 | Modulation of monomethylhydrazine-induced seizures by ivermectin. ( Horton, ML; Mayer, TW, 1991) |
| "AOAA also induced clonic convulsions in mice subjected to intracerebroventricular administration of the drug with a CD50 of 0." | 1.28 | Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. ( Calderazzo-Filho, LS; Cavalheiro, EA; Dziki, M; Turski, WA; Urbanska, E, 1991) |
| "In 75 occasions, the convulsion stopped within a period of 2 to 5 minutes, in 12 other times there was a need for repeated dosages and in 2 occasions, a third doses was needed." | 1.28 | [Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents]. ( Calderón González, R, 1991) |
| "Dogs dosed chronically (4-7 weeks) with oral flunitrazepam (7." | 1.28 | A comparison of the physical dependence inducing properties of flunitrazepam and diazepam. ( Martin, WR; Sloan, JW; Wala, EP, 1991) |
| "When the soman-induced convulsions were blocked, the decrease in muscarinic receptors at 3 days was less extensive than when convulsions occurred and at 10 days they approached control levels in most of the brain areas." | 1.28 | Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors. ( Churchill, L; Cross, RS; Nelson, SR; Pazdernik, TL; Samson, FE, 1990) |
| "MK-801, at all doses, reduced seizures in all groups (p less than or equal to 0." | 1.28 | Antagonism of cocaine, amphetamine, and methamphetamine toxicity. ( Albertson, TE; Derlet, RW; Rice, P, 1990) |
| "When haloperidol (1." | 1.28 | Protection against d-amphetamine toxicity. ( Albertson, TE; Derlet, RW; Rice, P, 1990) |
| "beta CCM to cause convulsions, suggesting that sites other than the SNpr are of prime importance in expressing the convulsant actions of systemically injected beta CCM." | 1.28 | Tolerance to diazepam and methyl-beta-carboline-3-carboxylate measured in substantia nigra of benzodiazepine tolerant rats. ( Chiu, TH; Rosenberg, HC; Tietz, EI; Zhang, H, 1990) |
| "Diazepam was demonstrated to have anticonvulsant properties in juvenile rats by both prolonging the time to develop the fully kindled response during acquisition and by reducing the elicited seizure severity and the length of the afterdischarge in the fully kindled juvenile rats." | 1.28 | Modification of amygdaloid kindling by diazepam in juvenile rats. ( Albertson, TE; Derlet, RW; Stark, LG, 1990) |
| "When diazepam was used as the dependence-producing drug, a 2." | 1.28 | Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice. ( Belknap, JK; Crabbe, JC; Laursen, SE, 1989) |
| "Like 1 and 2, tonic-clonic seizures were induced when trans-3 or -4 were administered to mice intracerebroventricularly." | 1.27 | Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo. ( Enna, SJ; Fung, YK; Patch, RJ; Witiak, DT, 1986) |
| "With flunitrazepam pretreatment, there were no deaths after lidocaine and only one after bupivacaine." | 1.27 | A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions. ( Aronson, HB; Vatashsky, E; Zaroura, S, 1983) |
| "Dogs, surgically implanted with a gastric fistula, were chronically dosed with diazepam or lorazepam." | 1.27 | Physical dependence on diazepam and lorazepam in the dog. ( Cherian, S; Martin, WR; McNicholas, LF, 1983) |
| " for 14 days) the corresponding dose-response lines were shifted to the right suggesting tolerance development." | 1.27 | Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal. ( Gonzalez, JP; McCulloch, AJ; Nicholls, PJ; Sewell, RD; Tekle, A, 1984) |
| " A kinetic analysis for the dose-response relation obtained gave 2." | 1.27 | The benzodiazepine receptor and receptor tolerance produced by chronic treatment of diazepam. ( Fuchino, K; Fujii, T; Hironaka, T, 1983) |
| "We think this decline is caused by seizures since phenobarbital pretreatment prevented the appearance of limbic seizures and blocked the receptor decline." | 1.27 | Benzodiazepine receptor declines in hippocampal formation following limbic seizures. ( Dasheiff, RM; Fanelli, RJ; Kraus, VM; McNamara, JO, 1983) |
| "DMCM seizures were antagonized by benzodiazepine (BZ) receptor antagonists, such as Ro 15-1788, CGS 8216 and several beta-carboline-3-carboxylates, which all fail to inhibit pentylenetetrazol seizures." | 1.27 | DMCM: a potent convulsive benzodiazepine receptor ligand. ( Petersen, EN, 1983) |
| "Diazepam was selectively antagonized by RO15-1788." | 1.27 | Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB. ( Ashton, D, 1983) |
| "This diazepam-elicited increase in Bmax is blocked in mice receiving the diazepam antagonist Ro 15-1788 (ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4] benzodiazepine-3-carboxylate)." | 1.27 | Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. ( Costa, E; Ferrero, P; Guidotti, A, 1984) |
| "Ro 15-1788 antagonised the tonic convulsions triggered by the drug combinations when it was given at the same time as Ro 5-4864; this antagonism was not observed when the drugs were injected at different times." | 1.27 | On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain. ( File, SE; Green, AR; Nutt, DJ; Vincent, ND, 1984) |
| "Low doses of CL 218,872 enhanced the convulsions produced by all agents except PTZ." | 1.27 | A benzodiazepine antagonist action of CL 218,872. ( Garrett, KM; Melchior, CL; Tabakoff, B, 1984) |
| "Though the convulsions looked similar to morphine-induced seizures, naloxone failed to antagonize these effects." | 1.27 | Possible mechanism of digoxin-induced convulsions. ( Kulkarni, SK; Mehta, AK, 1983) |
| "The onset of convulsions and mortality due to PTX were significantly delayed." | 1.27 | Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions. ( Jog, MV; Kulkarni, SK, 1983) |
| "When phenobarbital was administered for several days, a strong induction of hepatic microsomal enzymes occurred." | 1.27 | Anticonvulsant potency of common antiepileptic drugs in the gerbil. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Diazepam treatment during the course of kindling significantly increased the number of stimulation trials required to produce stage 5 motor seizures but did not inhibit the fall in CaBP." | 1.27 | Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants. ( Baimbridge, KG; Miller, JJ, 1984) |
| " A variety of currently available local anesthetic compounds has been deemed safe for common usage in the field of anesthesia." | 1.27 | Local anesthetic toxicity: review and case studies. ( Kalil, AL, 1983) |
| "The ED50s to inhibit seizure pattern in EEG were 30." | 1.27 | Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats. ( Kamei, C; Sunami, A; Tasaka, K, 1983) |
| "Diazepam (4 mg/kg) was completely effective in blocking GDSC 2 hr post administration." | 1.27 | Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam. ( Syapin, PJ, 1983) |
| "In 71%, the convulsion ceased within 5 min, and in 7%, between 5 and 10 min." | 1.27 | Rectal diazepam solution in the treatment of convulsions in the children's emergency room. ( Okonofua, JA; Sykes, RM, 1988) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| " In neither case were the pharmacological changes induced by chronic administration reflected by changes in the biochemical measures of the coupling between benzodiazepine binding sites and gamma-aminobutyric acid (GABA) receptors." | 1.27 | Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice. ( Schneider, HH; Stephens, DN, 1988) |
| "Soman (100 micrograms/kg; sc) produced convulsions in 63% of the saline-pretreated rats, whereas with LiCl pretreatment all rats exposed to 100 micrograms/kg of soman had tonic-clonic convulsions." | 1.27 | Soman-induced convulsions affect the inositol lipid signaling system: potentiation by lithium; attenuation by atropine and diazepam. ( Nelson, SR; Pazdernik, TL; Samson, FE; Savolainen, KM, 1988) |
| "Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions." | 1.27 | Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988) |
| "Similar proportional reductions in seizure afterdischarge durations were seen with diazepam and with RO 15-1788 after aminophylline although the absolute length of the afterdischarge durations were increased significantly with both drugs after aminophylline." | 1.27 | Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats. ( Albertson, TE; Foulke, GE, 1987) |
| "Pretreatment with atropine alone did not prevent paraoxon-induced seizures but did reduce mortality." | 1.27 | Comparative effects of diazepam and midazolam on paraoxon toxicity in rats. ( Domino, EF; Krutak-Krol, H, 1985) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 1.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "kainic acid were a decrease in noradrenaline and an increase in 5-hydroxyindoleacetic acid in the acute (3 h after kainic acid injection) suggesting strongly increased neurotransmitter turnover in noradrenergic and serotonergic neurons." | 1.27 | Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures. ( Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G, 1985) |
| "Pentylenetetrazole and picrotoxin seizure thresholds, measured during constant rate iv infusion, were significantly lowered by pretreatment with diazepam (250 mg/kg) and Ro 15-1788 (20 mg/kg) administered 30 and 20 minutes, respectively, before seizure threshold measurement." | 1.27 | Convulsant component of a depressant benzodiazepine. ( Bourn, WM; Garrett, RL, 1985) |
| "Pentobarbital and diazepam were effective against both tonic and clonic seizure components induced by bicuculline and picrotoxin." | 1.27 | Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism. ( Rastogi, SK; Ticku, MK, 1986) |
| "While Metrazole still elicited seizures during this period, reinduction of c-fos was largely refractory." | 1.27 | Mapping patterns of c-fos expression in the central nervous system after seizure. ( Cohen, DR; Curran, T; Hempstead, JL; Morgan, JI, 1987) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| " Following a four week dosing period with 30 mg/kg of either CGS 9896 or diazepam, the drugs were withdrawn and similar behavioral measures obtained at various withdrawal intervals up to 15 days." | 1.27 | Lack of tolerance or withdrawal effects in mice after chronic administration of the non-sedating anxiolytic, CGS 9896. ( Boast, CA; Gerhardt, SC, 1987) |
| "The diazepam preparations were administered intravenously to male mice." | 1.27 | The anticonvulsive activity and toxicity of diazepam in three different formulations. An experimental study in mice. ( Angelo, H; Bredgaard Sørensen, M; Carl, P; Høgskilde, S; Nielsen, JW, 1987) |
| "Diazepam's impact on kainic acid seizure-induced local cerebral glucose utilization (LCGU) was assessed by a quantitative [14C]2-deoxyglucose method." | 1.27 | Attenuation of cerebral glucose use in kainic acid-treated rats by diazepam. ( Chastain, JE; Nelson, SR; Pazdernik, TL; Samson, F, 1987) |
| "Behaviorally, the animals showed motor seizures which varied between stages I through IV, with evidence of extensive bilateral hemispheric involvement through much of the seizure episode." | 1.27 | Status epilepticus facilitated by pilocarpine in amygdala-kindled rats. ( Buterbaugh, GG; Keyser, DO; Michelson, HB, 1986) |
| "Bicyclic phosphorus esters (BCP) originating from the combustion of fire-retardant polyurethane foam containing phosphorus are highly toxic compounds and potent antagonists of GABA-ergic receptors." | 1.27 | [Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters]. ( Emilianowicz, J; Smok, W, 1986) |
| "Verapamil significantly decreased seizure incidence and both it and flunarizine lowered mortality." | 1.27 | Calcium channel antagonists decrease the ethanol withdrawal syndrome. ( Dolin, SJ; Halsey, MJ; Little, HJ, 1986) |
| "Diazepam (0." | 1.27 | Intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs. ( Lathers, CM; McNamara, RM; Spivey, WH; Unger, HD, 1987) |
| "Diazepam, known to produce its anticonvulsant, sedative and muscle relaxant effects through its interaction either with central GABA or glycine receptors was found to be the most potent (48." | 1.27 | Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice. ( Sangiah, S, 1985) |
| "d-Tubocurarine (d-TC) is a drug commonly used to produce muscle paralysis." | 1.27 | d-Tubocurarine causes neuronal death when injected directly into rat brain. ( Dasheiff, RM, 1985) |
| " Observation of behaviour indicated that the novel GABA uptake blockers exerted no side-effects in anticonvulsant doses, whereas diazepam produced sedative effects at all active dosage levels." | 1.27 | Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats. ( Löscher, W; Schwark, WS, 1985) |
| "Like seizure susceptibility, the differences in benzodiazepine binding were age-related." | 1.26 | Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice. ( Robertson, HA, 1980) |
| " It means that over this dosage range haloperidol potentiates GABA-induced effects." | 1.26 | [Participation of GABA-ergic structures in producing the effects of haloperidol]. ( Molodavkin, GM; Ostrovskaia, RU, 1980) |
| "They also increased the seizure threshold doses of intravenously infused pentetrazol and picrotoxin." | 1.26 | Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam. ( Zetler, G, 1980) |
| "Interictal discharges and seizures changed in different ways after intramuscular injection of diazepam." | 1.26 | [Electrical activity and Na, K-ATPase levels in an epileptic focus caused by application of penicillin to rat cerebral cortex and the effect of diazepam on them]. ( Kryzhanovskiĭ, GN; Rekhtman, MB; Samsonova, NA, 1980) |
| "In contrast neither the seizure threshold raising or sedative effect of melatonin (200 mg/kg) was reversed by Ro 15-1788." | 1.26 | Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663. ( Cowen, PJ; Green, AR; Nutt, DJ, 1982) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| "Etidocaine and bupivacaine convulsions were more difficult to suppress than those induced by lidocaine." | 1.26 | Benzodiazepines protect mice from local anesthetic convulsions and deaths. ( Bonin, JD; de Jong, RH, 1981) |
| "General supportive care and seizure control with physostigmine resulted in complete recovery within 72 hours." | 1.26 | Hydroxyzine intoxication in a 13-month-old child. ( Betlach, CJ; Derrick, CW; Magera, BE; Sweatt, AP, 1981) |
| "Kainic acid (KA) was injected systemically, intracerebroventricularly (i." | 1.26 | The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid. ( Ben-Ari, Y; Meldrum, BS; Ottersen, OP; Tremblay, E, 1980) |
| "22 patients with severe preeclampsia-eclampsia were treated in our Intensive Care Unit from 1972 to 1978." | 1.26 | [Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)]. ( Larsen, R; Radke, J; Turner, E, 1980) |
| "The diazepam effects were seen both in the intact brain and in the preparations of cerveau isolé and cortex isolé." | 1.26 | [Formation of an epileptic complex in the cerebral cortex and effect of diazepam on it with different levels of cerebral transection]. ( Kryzhanovskiĭ, GN; Lebediuk, MN; Lobasiuk, BA; Makul'kin, RF; Shandra, AA, 1980) |
| "Ketamine was administered to 18 baboons (Papio papio) to disrupt epileptic discharges elicited through intracarotid air injection." | 1.26 | [Action of ketamine of paroxysmal discharges provoked by air emboli in the baboon Papio papio]. ( Arfel, G; De Lavarde, M; De Pommery, H; De Pommery, J, 1976) |
| "Diazepam was found to block the generalized component of the cortico-generalized electrographic and motor seizure leaving the tonus only slightly suppressed." | 1.26 | The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures. ( Burnham, WM; Livingston, K; Racine, R, 1979) |
| "Phenobarbital was effective in diminishing the frequency of GHB-induced myoclonic jerks only when given prior to administration of GHB." | 1.26 | Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs. ( Snead, OC, 1978) |
| "Diazepam also abolishes clonic convulsions induced by electrical stimulation of the brain." | 1.26 | [Na, K-ATPase activity of the meninges in electroshock and the action of the anticonvulsant agent, diazepam]. ( Glebov, RN; Golenda, AM; Kryzhanovskiĭ, GN, 1979) |
| " Acetaminophen and diazepam seemed to be well absorbed from the rectal suppositories, the maximal plasma concentration of diazepam after a rectal dose of 0." | 1.26 | Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children. ( Kangas, L; Keinänen-Kiukaanniemi, S; Luoma, P; Saukkonen, AL; Similä, S, 1979) |
| "5." | 1.26 | The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam. ( Anhut, H; Hertting, G; Steinhauer, HB, 1979) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| "Papaverine in low doses was ineffective, but in higher doses lowered PSAT; it antagonized the effect of GAMA, elevating the threshold." | 1.26 | [Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam]. ( Georgiev, V, 1978) |
| "Eighty-seven per cent of convulsions lasted for less than 15 minutes and in only two instances did they last longer than 30 minutes." | 1.26 | Febrile convulsions--what do parents do? ( Metcalfe, DH; Rutter, N, 1978) |
| "Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy." | 1.26 | Diazepam in the prophylaxis of lignocaine seizures. ( Ausinsch, B; Malagodi, MH; Munson, ES, 1976) |
| "Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC." | 1.26 | Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. ( Consroe, P; Eisenstein, D; Martin, P, 1977) |
| "When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions." | 1.26 | Potentiation of Amipaque epileptogenic activity by neuroleptics. ( Brucher, JM; Gonsette, RE, 1977) |
| "Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations." | 1.26 | Neonatal seizures associated with narcotic withdrawal. ( Herzlinger, RA; Kandall, SR; Vaughan, HG, 1977) |
| "Although Dimer X is said to be a low toxic water soluble contrast medium, epileptic seizures sometimes occur during or after Dimer X ventriculography." | 1.26 | Intracisternal dimer X: toxicity and prophylaxis. ( Nishikawa, M; Yonekawa, Y, 1976) |
| "EEG changes and convulsions were elicited by 2." | 1.26 | [Influence of diazepam and phenytoin on penicillin-induced cerebral convulsions (author's transl)]. ( Höffler, D; Köhler, H; Krieglstein, J; Rieger, H; Voigt, R; Weihrauch, TR, 1976) |
| "3) Pregnancy was abnormal in 53% of cases with cerebral malformation." | 1.26 | Etiology of convulsions in neonatal and infantile period. ( Hanai, T; Kurokawa, T; Nambu, Y; Takashima, S; Yokata, K, 1976) |
| " The pathogenesis points to a multifactorial occurrence caused by the coincidence of an increased dosage of the contrast media, too bed rest time, rising of the contrast media in the spinal cord zone and disturbed liquor fluid circulation and contrast media resorption." | 1.26 | [Side reaction after lumbar myelography with dimer-x (author's transl)]. ( Egli, M; Walker, N; Wellauer, J, 1976) |
| "Different strengths of seizure foci were induced by penicillin G 1000, 3000 and 6000 U injected into the cortex, amygdala and intralaminal thalamus, and the spread of epileptic discharges in the subcortex or surrounding area and to the contralateral area was followed." | 1.26 | [Depressive effects of benzodiazepines on penicillin-induced epileptic discharges]. ( Fukushima, H; Kitagawa, S; Tsuchiya, T, 1976) |
| "Simple febrile convulsions occur in otherwise normal children, aged six months to five years, with extracranial infection." | 1.26 | Simple febrile convulsions. ( Mendelsohn, J; Rosen, P; Tomlanovich, MC, 1976) |
| "The adverse effects in a series of 50 lumbar myelographies with Amipaque were compared with those in a corresponding series, examined with Dimer-X." | 1.26 | Adverse effects of lumbar myelography with amipaque and dimer-X. ( Irstam, L; Selldén, U, 1976) |
| "Clorazepate dipotassium and diazepam were administered daily for the first 5 days of each week to Rhesus monkeys at equimolar doses and challanged once a week with a convulsant dose of pentylenetetrazol." | 1.25 | Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys. ( O'Brien, GS; Plotnikoff, NP, 1974) |
| "Diazepam was shown to be highly efficient in preventing the convulsive siezures induced by thiosemicarbazide and connected with GABA insufficiency." | 1.25 | [The mechanism of the anticonvulsive action of diazepam]. ( Molodavkin, GM; Ostrovskaia, RU; Porfir'eva, RP; Zubovskaia, AM, 1975) |
| "Diazepam pretreatment raised the seizure threshold of bupivacaine." | 1.25 | Central nervous system effects of bupivacaine. ( Jenkins, LC; Robinson, WM, 1975) |
| "Recurrence of seizures in 2 children indicated that the anticonvulsants plasma level was of the order of 150 to 200 mug/liter." | 1.25 | Plasma levels of diazepam after parenteral and rectal administration in children. ( Agurell, S; Berlin, A; Ferngren, H; Hellström, B, 1975) |
| " For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 1.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
| "Hyperreflexia and periodic convulsions were controlled by initial intramuscular injections of 30 mg diazepam and 2 g methocarbamol, followed at 6-hour intervals with intramuscular injections of 30 mg diazepam each, for 2 additional treatments." | 1.25 | The use of diazepam and methocarbamol in the treatment of toxaphene poisoning in a Bangal tiger. ( Peavy, GM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 561 (47.02) | 18.7374 |
| 1990's | 222 (18.61) | 18.2507 |
| 2000's | 175 (14.67) | 29.6817 |
| 2010's | 157 (13.16) | 24.3611 |
| 2020's | 78 (6.54) | 2.80 |
| Authors | Studies |
|---|---|
| Gall, M | 1 |
| Lahti, RA | 1 |
| Rudzik, AD | 2 |
| Duchamp, DJ | 1 |
| Chidester, C | 1 |
| Scahill, T | 1 |
| Tomczuk, BE | 1 |
| Taylor, CR | 1 |
| Moses, LM | 1 |
| Sutherland, DB | 1 |
| Lo, YS | 1 |
| Johnson, DN | 1 |
| Kinnier, WB | 1 |
| Kilpatrick, BF | 1 |
| Shindo, H | 2 |
| Takada, S | 3 |
| Murata, S | 2 |
| Eigyo, M | 2 |
| Matsushita, A | 2 |
| Toja, E | 1 |
| Tarzia, G | 1 |
| Barone, D | 1 |
| Luzzani, F | 1 |
| Gallico, L | 1 |
| Witiak, DT | 1 |
| Patch, RJ | 1 |
| Enna, SJ | 1 |
| Fung, YK | 1 |
| Sasatani, T | 1 |
| Kawasaki, K | 1 |
| Fatmi, AA | 1 |
| Vaidya, NA | 1 |
| Iturrian, WB | 1 |
| Blanton, CD | 1 |
| Lukovits, I | 1 |
| Lopata, A | 1 |
| Kane, JM | 1 |
| Staeger, MA | 1 |
| Dalton, CR | 1 |
| Miller, FP | 1 |
| Dudley, MW | 1 |
| Ogden, AM | 1 |
| Kehne, JH | 1 |
| Ketteler, HJ | 1 |
| McCloskey, TC | 1 |
| Senyah, Y | 1 |
| Jacobsen, EJ | 4 |
| Stelzer, LS | 2 |
| Belonga, KL | 2 |
| Carter, DB | 4 |
| Im, WB | 3 |
| Sethy, VH | 4 |
| Tang, AH | 4 |
| VonVoigtlander, PF | 2 |
| Petke, JD | 3 |
| Mickelson, JW | 2 |
| Im, HK | 2 |
| Schreur, PJ | 1 |
| McGee, JE | 1 |
| Pevarello, P | 1 |
| Bonsignori, A | 1 |
| Dostert, P | 1 |
| Heidempergher, F | 1 |
| Pinciroli, V | 1 |
| Colombo, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Post, C | 1 |
| Fariello, RG | 1 |
| Varasi, M | 1 |
| Da Settimo, A | 1 |
| Primofiore, G | 1 |
| Da Settimo, F | 1 |
| Marini, AM | 1 |
| Novellino, E | 2 |
| Greco, G | 1 |
| Gesi, M | 1 |
| Martini, C | 5 |
| Giannaccini, G | 2 |
| Lucacchini, A | 2 |
| TenBrink, RE | 1 |
| Zhong, WZ | 1 |
| Jordan, AD | 1 |
| Vaidya, AH | 1 |
| Rosenthal, DI | 1 |
| Dubinsky, B | 1 |
| Kordik, CP | 1 |
| Sanfilippo, PJ | 1 |
| Wu, WN | 1 |
| Reitz, AB | 1 |
| Costanzo, A | 4 |
| Guerrini, G | 4 |
| Ciciani, G | 4 |
| Bruni, F | 4 |
| Costagli, C | 1 |
| Selleri, S | 4 |
| Besnard, F | 2 |
| Costa, B | 1 |
| Malmberg-Aiello, P | 1 |
| Zarghi, A | 1 |
| Faizi, M | 2 |
| Shafaghi, B | 3 |
| Ahadian, A | 1 |
| Khojastehpoor, HR | 1 |
| Zanganeh, V | 1 |
| Tabatabai, SA | 2 |
| Shafiee, A | 4 |
| Grunwald, C | 2 |
| Rundfeldt, C | 4 |
| Lankau, HJ | 2 |
| Arnold, T | 1 |
| Höfgen, N | 1 |
| Dost, R | 2 |
| Egerland, U | 2 |
| Hofmann, HJ | 1 |
| Unverferth, K | 2 |
| Hartenhauer, H | 1 |
| Heinecke, K | 1 |
| Bernöster, K | 1 |
| Cambi, G | 2 |
| Montali, M | 2 |
| Ghelardini, C | 4 |
| Galeotti, N | 1 |
| Mirón-López, G | 1 |
| Herrera-Ruiz, M | 1 |
| Estrada-Soto, S | 1 |
| Aguirre-Crespo, F | 1 |
| Vazquez-Navarrete, L | 1 |
| León-Rivera, I | 1 |
| Melani, F | 1 |
| Norcini, M | 2 |
| Anzini, M | 1 |
| Braile, C | 1 |
| Valenti, S | 2 |
| Cappelli, A | 1 |
| Vomero, S | 1 |
| Marinelli, L | 1 |
| Limongelli, V | 1 |
| Betti, L | 1 |
| Makovec, F | 1 |
| Giorgi, G | 1 |
| Ian Fryer, R | 1 |
| Marona, H | 2 |
| Pekala, E | 2 |
| Antkiewicz-Michaluk, L | 1 |
| Walczak, M | 1 |
| Szneler, E | 1 |
| Rivas, FM | 1 |
| Stables, JP | 1 |
| Murphree, L | 1 |
| Edwankar, RV | 1 |
| Edwankar, CR | 1 |
| Huang, S | 1 |
| Jain, HD | 1 |
| Zhou, H | 1 |
| Majumder, S | 1 |
| Sankar, S | 1 |
| Roth, BL | 1 |
| Ramerstorfer, J | 1 |
| Furtmüller, R | 1 |
| Sieghart, W | 1 |
| Cook, JM | 3 |
| Gupta, SV | 1 |
| Baheti, K | 1 |
| Bora, R | 1 |
| Dekhane, D | 1 |
| Chhabría, M | 1 |
| Shingare, M | 1 |
| Pawar, S | 1 |
| Shishoo, CJ | 1 |
| Thore, SN | 1 |
| Aly, MM | 1 |
| Mohamed, YA | 1 |
| El-Bayouki, KA | 1 |
| Basyouni, WM | 1 |
| Abbas, SY | 1 |
| Daniele, S | 1 |
| Di Cesare Mannelli, L | 1 |
| Ugale, VG | 1 |
| Patel, HM | 1 |
| Wadodkar, SG | 1 |
| Bari, SB | 1 |
| Shirkhedkar, AA | 1 |
| Surana, SJ | 1 |
| Prasanthi, G | 1 |
| Prasad, KV | 1 |
| Bharathi, K | 1 |
| Mashayekh, S | 1 |
| Rahmanipour, N | 1 |
| Mahmoodi, B | 1 |
| Ahmadi, F | 1 |
| Motaharian, D | 1 |
| Shahhosseini, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 12-Month Open-Label, Repeat-Dose Safety Study of NRL-1 in Epilepsy Subjects (DIAZ.001.05)[NCT02721069] | Phase 3 | 175 participants (Actual) | Interventional | 2016-04-11 | Completed | ||
| A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786] | Phase 2 | 120 participants (Anticipated) | Interventional | 2020-12-08 | Enrolling by invitation | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175] | Phase 2 | 150 participants (Anticipated) | Interventional | 2020-01-27 | Recruiting | ||
| An Open-Label, Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects Under Seizure and Normal Conditions[NCT02724423] | Phase 1 | 57 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Big Data Construction and Biological Etiological Epidemiology Study of Children Epilepsy in China[NCT02969213] | 10,000 participants (Anticipated) | Observational | 2016-11-30 | Not yet recruiting | |||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study of Neotrofin to Treat Patients With Sensory or Motor Neuropathy Caused by Chemotherapy for Cancer[NCT00041795] | Phase 2 | 50 participants | Interventional | 2002-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assess the number of participants who received at least one dose of NRL-1 (Valtoco) during the study and comprised the safety population. (NCT02721069)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| NRL-1 5mg | 9 |
| NRL-1 10mg | 54 |
| NRL-1 15 mg | 46 |
| NRL-1 20mg | 54 |
Evaluate the pharmacokinetics (PK), in terms of Cmax, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.
| Intervention | ng/mL (Geometric Mean) |
|---|---|
| NRL-1 ICTAL/PERI-ICTAL | 135 |
| NRL-1 INTER-ICTAL | 153 |
Evaluate the pharmacokinetics (PK), in terms of AUC, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.
| Intervention | ng*hr/mL (Geometric Mean) |
|---|---|
| NRL-1 ICTAL/PERI-ICTAL | 435 |
| NRL-1 INTER-ICTAL | 502 |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
74 reviews available for diazepam and Absence Seizure
| Article | Year |
|---|---|
Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Humans; Molecular Structure; Seizures; Structure-A | 2020 |
Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis.
Topics: Administration, Intranasal; Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Midazolam; Pr | 2021 |
Management of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Seizures; Status Epilepticus | 2022 |
Rescue therapies in epilepsy.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Diazepam; Epilepsy; Humans; Seizures | 2022 |
Comparative efficacy and safety of pharmacotherapies for alcohol withdrawal: a systematic review and network meta-analysis.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Carbamazepine; Diazepam; Female; Hu | 2022 |
Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.
Topics: Anticonvulsants; Benzodiazepines; Child; Diazepam; Humans; Lorazepam; Midazolam; Network Meta-Analys | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy, | 2022 |
Rescue Treatments for Seizure Clusters.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Humans; Lorazepam; Midazolam; Nasal S | 2022 |
Seizure rescue medications are missing from in-flight medical emergency kits.
Topics: Aerospace Medicine; Diazepam; First Aid; Humans; Midazolam; Seizures | 2022 |
Second Generation of Antiepileptic Drugs and Oxidative Stress.
Topics: Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; Hum | 2023 |
Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Nasa | 2023 |
Diazepam buccal film for the treatment of acute seizures.
Topics: Acute Disease; Administration, Buccal; Anticonvulsants; Diazepam; Humans; Seizures | 2019 |
Seizure Rescue Medications for Out-Of-Hospital Use in Children.
Topics: Administration, Intranasal; Administration, Rectal; Anticonvulsants; Benzodiazepines; Child; Diazepa | 2021 |
Rescue therapies for seizure emergencies: current and future landscape.
Topics: Anticonvulsants; Child; Diazepam; Emergencies; Humans; Seizures; Status Epilepticus | 2021 |
A review of a diazepam nasal spray for the treatment of acute seizure clusters and prolonged seizures.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Humans; Nasal Sprays; Quality of Life; Seizur | 2021 |
Classics in chemical neuroscience: diazepam (valium).
Topics: Anxiety Disorders; Diazepam; Dose-Response Relationship, Drug; Drug Design; Drug Overdose; Humans; R | 2014 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Intranasal therapies for acute seizures.
Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; | 2015 |
Recent advances in status epilepticus.
Topics: Amides; Anticonvulsants; Diazepam; Humans; Midazolam; Seizures; Status Epilepticus | 2016 |
Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Seizures; Status Epilepticus; Treatment Outcome | 2016 |
Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials.
Topics: Administration, Intravenous; Anticonvulsants; Diazepam; Humans; Lorazepam; Randomized Controlled Tri | 2016 |
Why is the developing brain more susceptible to status epilepticus?
Topics: Animals; Animals, Newborn; Brain; Diazepam; Disease Models, Animal; Female; Humans; Male; Pentobarbi | 2009 |
Clinical practice: the treatment of acute convulsive seizures in children.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Diazepam; GABA Modulators; Humans; Lorazepam | 2011 |
Therapy with hypertonic saline in combination with anti-convulsants for hyponatremia-induced seizure: a case report and review of the literature.
Topics: Aged; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Humans; | 2002 |
The short-term outcome of seizure management by prehospital personnel: a comparison of two protocols.
Topics: Anticonvulsants; Case Management; Child; Child, Preschool; Clinical Protocols; Diazepam; Dose-Respon | 2003 |
Management of seizures in children with falciparum malaria.
Topics: Anticonvulsants; Child; Diazepam; Emergency Treatment; Humans; Malaria, Cerebral; Malaria, Falciparu | 2004 |
Best evidence topic report. Buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Child; Diazepam; Emergency Medical Servi | 2005 |
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; C | 1981 |
Drug therapy. Current status of benzodiazepines.
Topics: Alcoholic Beverages; Alcoholism; Anesthetics; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Bone Di | 1983 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam | 1981 |
Structure-activity relationships in kynurenine, diazepam and some putative endogenous ligands of the benzodiazepine receptors.
Topics: Animals; Binding, Competitive; Brain; Diazepam; Kynurenine; Mice; Peptide Fragments; Receptors, Cell | 1983 |
Constant diazepam infusion in the treatment of continuous seizure activity.
Topics: Diazepam; Drug Stability; Emergencies; Humans; Infant; Infant, Newborn; Infusions, Parenteral; Prosp | 1984 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Local anesthetic drugs: tissue and systemic toxicity.
Topics: Anesthesia, Conduction; Anesthetics, Local; Animals; Apnea; Arrhythmias, Cardiac; Barbiturates; Cent | 1981 |
Acute buflomedil intoxication: a life-threatening condition.
Topics: Acute Disease; Adolescent; Combined Modality Therapy; Diazepam; Electroencephalography; Fatal Outcom | 1994 |
Treatment of acute isoniazid overdose in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Antitubercular Agents; Cats; Diazepam; Dog Diseases; | 1995 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
[Cocaine-induced neurological complications].
Topics: Anticonvulsants; Cerebral Hemorrhage; Cerebral Infarction; Cocaine; Diazepam; Headache; Humans; Isch | 1996 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va | 1997 |
[Rectal diazepam for treatment and prevention of seizures in children].
Topics: Administration, Rectal; Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; | 1998 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
New therapies in the management of acute or cluster seizures and seizure emergencies.
Topics: Administration, Rectal; Anticonvulsants; Diazepam; Drug Delivery Systems; Gels; Home Nursing; Humans | 1999 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Seizures in the newborn.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Electroencephalography; Humans; Infant, Newborn; Neonata | 2001 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Selection among benzodiazepines for alcohol withdrawal.
Topics: Administration, Oral; Benzodiazepines; Central Nervous System; Chlordiazepoxide; Clorazepate Dipotas | 1977 |
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Management of seizure disorders: selected aspects. Part I.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography, | 1976 |
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 1975 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
Neurologic complications of cocaine abuse.
Topics: Cocaine; Diazepam; Humans; Nervous System Diseases; Seizures; Substance-Related Disorders | 1990 |
[New aspects of anticonvulsive therapy in severe pre-eclampsia and eclampsia].
Topics: Anticonvulsants; Chlormethiazole; Diazepam; Eclampsia; Female; Humans; Infant, Newborn; Magnesium Su | 1989 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
A molecular approach to the calcium signal in brain: relationship to synaptic modulation and seizure discharge.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding, Competitive; Brain; Calcium; Calmodulin; Carbama | 1986 |
The child with febrile seizures.
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Fever; Humans; Infant; Phenobarbital; Prognosis | 1987 |
[Eclamptic fits: etiologic mechanisms, clinical aspects and therapy].
Topics: Animals; Calcium Gluconate; Cardiac Catheterization; Critical Care; Diazepam; Dogs; Eclampsia; Elect | 1986 |
Febrile seizures: emergency department diagnosis and treatment.
Topics: Blood Cell Count; Blood Glucose; Child, Preschool; Counseling; Diagnosis, Differential; Diazepam; Dr | 1985 |
[Psychopharmacological agents in children].
Topics: Acetylcholine; Aminobutyrates; Antipsychotic Agents; Cerebral Palsy; Child; Chlordiazepoxide; Diazep | 1973 |
Drug therapy. Benzodiazepines (second of two parts).
Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet | 1974 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Epilepsy.
Topics: Adolescent; Animals; Barbiturates; Brain Neoplasms; Cell Membrane Permeability; Central Nervous Syst | 1968 |
Acute and chronic toxicity of local anaesthetics.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Animals; Brain; Cats; Diazepam; Drug Hypersensitivity; | 1973 |
Side effects of depot fluphenazines.
Topics: Agranulocytosis; Barbiturates; Basal Ganglia Diseases; Benztropine; Biperiden; Delayed-Action Prepar | 1974 |
The continuing problem of purulent meningitis in infants and children.
Topics: Bacterial Vaccines; Bicarbonates; Brain Edema; Diagnosis, Differential; Diazepam; Digoxin; Fever; Ga | 1974 |
Convulsions in children.
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M | 1968 |
Advances in neurology.
Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra | 1968 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
47 trials available for diazepam and Absence Seizure
| Article | Year |
|---|---|
Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy, Generalized; Hospitals; Humans; Nas | 2022 |
Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Child; Diazepam; Double-Blind | 2022 |
Quality-of-life results in adults with epilepsy using diazepam nasal spray for seizure clusters from a long-term, open-label safety study.
Topics: Adult; Diazepam; Drug Resistant Epilepsy; Epilepsy, Generalized; Humans; Nasal Sprays; Quality of Li | 2022 |
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Levetiracetam; Phenytoin; Seizures; Status Epilepticus; Tr | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diazepam | 2023 |
Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study.
Topics: Anticonvulsants; Cannabidiol; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome | 2023 |
Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study.
Topics: Anticonvulsants; Brain Diseases; Child; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Lennox Ga | 2023 |
Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Diazepam; Epilepsy; Female; Humans; Male | 2020 |
Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain; Brain Waves; Diazepam; Double-Blind Method; | 2021 |
Lack of observed impact of history or concomitant treatment of seasonal allergies or rhinitis on repeated doses of diazepam nasal spray administered per seizure episode in a day, safety, and tolerability: Interim results from a phase 3, open-label, 12-mon
Topics: Administration, Intranasal; Child; Diazepam; Double-Blind Method; Humans; Nasal Sprays; Rhinitis; Se | 2021 |
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Dru | 2021 |
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome | 2021 |
Consistent safety and tolerability of Valtoco
Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures | 2021 |
Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Child; | 2021 |
Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures.
Topics: Administration, Intravenous; Administration, Rectal; Animals; Anticonvulsants; Diazepam; Dog Disease | 2019 |
Efficacy of sublingual lorazepam versus intrarectal diazepam for prolonged convulsions in Sub-Saharan Africa.
Topics: Administration, Rectal; Administration, Sublingual; Africa South of the Sahara; Anticonvulsants; Chi | 2014 |
Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures.
Topics: Acute Disease; Adolescent; Anticonvulsants; Caregivers; Child; Diazepam; Double-Blind Method; Drug D | 2014 |
Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Huma | 2015 |
Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial.
Topics: Administration, Buccal; Child; Child, Preschool; Diazepam; Female; Follow-Up Studies; Humans; Infant | 2009 |
Efficacy and usability of buccal midazolam in controlling acute prolonged convulsive seizures in children.
Topics: Acute Disease; Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Child, Presch | 2010 |
[A control study on the treatment of acute seizures with midazolam and diazepam in children].
Topics: Acute Disease; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Male; Midazolam; | 2010 |
Buccal midazolam or rectal diazepam for treatment of residential adult patients with serial seizures or status epilepticus.
Topics: Administration, Buccal; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; | 2011 |
Is intranasal midazolam better than rectal diazepam for home management of acute seizures?
Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Child; Diazepam; Disease Manageme | 2011 |
Intravenous diazepam, midazolam and lorazepam in acute seizure control.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Injections, In | 2012 |
A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures.
Topics: Administration, Intranasal; Administration, Intravenous; Child; Child, Preschool; Diazepam; Emergenc | 2013 |
Rectal diazepam gel for treatment of acute repetitive seizures in adults.
Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Aged; Chi-Square Distribution; Diazepam; D | 2002 |
Intramuscular midazolam vs intravenous diazepam for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Infant; Injections, Intramuscular; Injec | 2005 |
Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.
Topics: Administration, Intranasal; Child; Child, Preschool; Conscious Sedation; Diazepam; Female; Humans; H | 2006 |
Effectiveness of diazepam rectal gel in adults with acute repetitive seizures and prolonged seizures: a single-center experience.
Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Anticonvulsants; Body Weight; Diazepam; Di | 2007 |
Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial.
Topics: Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Child, Preschool; Developing | 2008 |
Diazepam prophylaxis of contrast media-induced seizures during computed tomography of patients with brain metastases.
Topics: Aged; Brain Neoplasms; Clinical Trials as Topic; Contrast Media; Diazepam; Humans; Radiotherapy Dosa | 1983 |
Buspirone: an anxioselective alternative for the management of anxiety disorders.
Topics: Aggression; Animals; Anxiety Disorders; Arousal; Avoidance Learning; Buspirone; Clinical Trials as T | 1983 |
Diazepam rectal solution for home treatment of acute seizures in children.
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Mal | 1981 |
The feasibility of a control population for a randomized control trial of seizure prophylaxis in the hypertensive disorders of pregnancy.
Topics: Anticonvulsants; Antihypertensive Agents; Diazepam; Feasibility Studies; Female; Humans; Magnesium S | 1995 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial.
Topics: Adult; Diazepam; Eclampsia; Female; Humans; Infant, Newborn; Magnesium Sulfate; Phenytoin; Pregnancy | 1995 |
A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children.
Topics: Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Inf | 1997 |
Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Diazepam; Double-Blind Me | 1998 |
Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa | 1999 |
Intranasal administration of diazepam aiming at the treatment of acute seizures: clinical trials in healthy volunteers.
Topics: Administration, Intranasal; Anticonvulsants; Clinical Trials as Topic; Diazepam; Humans; Injections, | 1999 |
Potential prophylactic use of benzodiazepines for hemodialysis-associated seizures.
Topics: Adolescent; Anticonvulsants; Blood Pressure; Child; Diazepam; Female; Humans; Male; Phenobarbital; R | 2000 |
[Prevention of febrile convulsions with diazepam or phenemal. A prospective controlled study].
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Humans; Infant; Phenobarbital; Prospect | 1978 |
Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study.
Topics: Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Phenobarbital; P | 1978 |
Intermittent home treatment of status and clusters of seizures.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Child; Child, Preschool; Clinical T | 1989 |
Treatment of alcohol withdrawal syndromes.
Topics: Chloral Hydrate; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Drug Synergism; Ethanol; Huma | 1971 |
Intravenous diazepam in the treatment of prolonged seizure activity in neonates and infants.
Topics: Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Infant, Newborn; Infan | 1971 |
1072 other studies available for diazepam and Absence Seizure
| Article | Year |
|---|---|
Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Crystallography; Hypnotics and Sedatives; Imid | 1978 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
Thienylpyrazoloquinolines with high affinity to benzodiazepine receptors: continuous shift from inverse agonist to agonist properties depending on the size of the alkyl substituent.
Topics: Animals; Chemical Phenomena; Chemistry; Diazepam; Drug Synergism; Male; Mice; Molecular Structure; P | 1989 |
Benzodiazepine receptor binding and anticonflict activity in a series of 3,6-disubstituted pyridazino[4,3-c]isoquinolines devoid of anticonvulsant properties.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Conflict, Psychological; Diazepam; Iso | 1985 |
Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Magnet | 1986 |
A new thienylpyrazoloquinoline: a potent and orally active inverse agonist to benzodiazepine receptors.
Topics: Administration, Oral; Animals; Anticonvulsants; Indicators and Reagents; Male; Mice; Pentylenetetraz | 1987 |
Synthesis of previously inaccessible quinazolines and 1,4-benzodiazepines as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Benzodiazepines; Mice; Pentylenetetrazole; Quinazolines; Receptors, Cell S | 1984 |
Decomposition of pharmacological activity indices into mutually independent components using principal component analysis.
Topics: Animals; Anti-Infective Agents; Benzodiazepines; Hydroxyquinolines; Mathematics; Pharmacology; Rifam | 1980 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Membrane; Cerebral Cortex; Drug Synergism; Ethanol; | 1996 |
High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines.
Topics: Animals; Cell Line; Humans; Ligands; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Membr | 1996 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators | 1998 |
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Convulsants; Diazepa | 1998 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebell | 1999 |
Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzimidazoles; Cerebral Cortex; Conflict, Psych | 2002 |
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Cell Line; Cerebral Cortex; Cycli | 2002 |
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Diazepam; Drug Design; Electroshock; Flumaze | 2005 |
Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding Sites; Brain; GABA Anta | 2006 |
New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Models, M | 2007 |
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Ataxia; Diazepam; Drug Design; GABA Agonists; gamma-Aminobuty | 2007 |
Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Glycolipids; Glycosides; Ileum; Ip | 2007 |
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies.
Topics: Animals; Anxiety; Behavior, Animal; Ethanol; Ligands; Male; Memory; Models, Molecular; Molecular Str | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Cr | 2008 |
Anticonvulsant activity of some xanthone derivatives.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Mice; Molecular Structure; | 2008 |
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Hippocampus; Kindling, Neurologic; Ligands; | 2009 |
Synthesis of novel bioactive derivatives of 3-(4-chlorophenyl)-2-hydrazino-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidine-4(3H)-ones.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Mice; Molecular Structure; Muscle, Ske | 2009 |
Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.
Topics: Analgesics; Animals; Anti-Infective Agents; Anticonvulsants; Antineoplastic Agents; Bacteria; Cell L | 2010 |
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.
Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan | 2011 |
Quinazolino-benzothiazoles: fused pharmacophores as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzothiazoles; Drug Design; Electroshock; Male; Mice; Pentylenetetrazole; | 2012 |
Synthesis, anticonvulsant activity and molecular properties prediction of dialkyl 1-(di(ethoxycarbonyl)methyl)-2,6-dimethyl-4-substituted-1,4-dihydropyridine-3,5-dicarboxylates.
Topics: Administration, Oral; Animals; Anticonvulsants; Dihydropyridines; Drug Design; Male; Mice; Molecular | 2014 |
Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Models, Molecular; Mole | 2014 |
Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Molecular Stru | 2014 |
Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzamides; Binding Sites; Disease Models, Animal; Half-Life; Liver; Mice; | 2014 |
Mechanism of action of antiepileptic ceramide from Red Sea soft coral Sarcophyton auritum.
Topics: Allosteric Regulation; Animals; Anthozoa; Anticonvulsants; Binding Sites; Ceramides; Disease Models, | 2015 |
Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents.
Topics: Acridines; Acridones; Animals; Anticonvulsants; Electroshock; Mice; Molecular Docking Simulation; Ox | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
HPLC-Based Activity Profiling for GABA
Topics: Animals; Blood-Brain Barrier; Molecular Structure; Pentylenetetrazole; Plant Extracts; Plant Roots; | 2017 |
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.
Topics: Animals; Azabicyclo Compounds; Blood-Brain Barrier; Cell Line, Tumor; Cell Proliferation; Humans; Me | 2018 |
Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.
Topics: Animals; Anticonvulsants; Brain; Characiformes; Diazepam; Diet; Euterpe; Lipid Peroxidation; Pentyle | 2021 |
Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model.
Topics: Analgesics; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Administration Schedule | 2021 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; | 2022 |
Comment on "Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: A systematic review and meta-analysis".
Topics: Administration, Intranasal; Benzodiazepines; Child; Diazepam; Humans; Seizures; Status Epilepticus | 2022 |
Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy, Generalized; Humans; Nasal Sprays; | 2022 |
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug | 2022 |
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents; | 2022 |
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electr | 2022 |
Use of new intranasal benzodiazepines at a typical adult epilepsy center.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Epilepsy, G | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Brain Damage, Chronic; Diazepam; Epilepsy; Epile | 2022 |
Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Capsaicin; Diazepam; Endocannabinoids; Mice; Pentylenetetrazole; Polyunsat | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Ra | 2022 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Successful Treatment of Amoxapine-Induced Intractable Seizures With Intravenous Lipid Emulsion.
Topics: Adult; Amoxapine; Antidepressive Agents, Second-Generation; Diazepam; Fat Emulsions, Intravenous; Fe | 2023 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Contraindications, Drug; Diazepam; Disease Model | 2022 |
Anxiolytic and anticonvulsant effect of Ibuprofen derivative through GABAergic neuromodulation in adult Zebrafish.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Humans; Ibuprofen; Seizures; Zebrafish | 2023 |
Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog.
Topics: Animals; Anticonvulsants; Diazepam; Mice; Oxazoles; Seizures | 2023 |
Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Topics: Animals; Biomarkers; Diazepam; Epilepsy; Intermediate Filaments; Kainic Acid; Ketamine; Mice; Neurof | 2023 |
Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children.
Topics: Anticonvulsants; Benzodiazepines; Case-Control Studies; Child; Diazepam; Drug Resistant Epilepsy; Hu | 2023 |
Neuroprotective anticonvulsant and anxiolytic effects of octreotide in wistar rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Male; Mice; Neuroprotective Agents; Octreot | 2023 |
Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats.
Topics: Animals; Diazepam; Fluoxetine; Plant Extracts; Rats; Rats, Wistar; Rutaceae; Seizures | 2023 |
A Comparative Analysis of Prehospital Emergency Treatments: Midazolam Intramuscularly, Diazepam Enema, and Chloral Hydrate Enema for Pediatric Convulsions.
Topics: Child; Chloral Hydrate; Diazepam; Emergency Medical Services; Enema; Humans; Midazolam; Seizures | 2023 |
Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.
Topics: Animals; Anticonvulsants; Diazepam; Humans; Male; Pentylenetetrazole; Phenobarbital; Phosphodiestera | 2023 |
Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cholinesterase Inhibitors; Di | 2019 |
Acute kidney injury, seizures, and hypertonic hyponatremia secondary to mannitol intoxication in a dog.
Topics: Acute Kidney Injury; Animals; Anticonvulsants; Creatinine; Diazepam; Dog Diseases; Dogs; Drug Overdo | 2019 |
Garlic passion fruit (Passiflora tenuifila Killip): Assessment of eventual acute toxicity, anxiolytic, sedative, and anticonvulsant effects using in vivo assays.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Anxiety; Behavior, Animal; Dia | 2020 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Kainic acid-induced seizures in the common marmoset.
Topics: Animals; Behavior, Animal; Callithrix; Diazepam; Female; Kainic Acid; Male; Seizures | 2020 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Intranasal diazepam (Valtoco) and midazolam (Nayzilam) for seizure clusters.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Humans; Midazolam; Seizures | 2020 |
Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Inflammation; Kindling, Neurologic; Male; Pe | 2020 |
Lorazepam Versus Diazepam in the Management of Emergency Department Patients With Alcohol Withdrawal.
Topics: Adult; Alcoholism; Benzodiazepines; Canada; Diazepam; Emergency Service, Hospital; Female; Hospitali | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Initial treatment of seizures in children in an emergency department in rural Japan.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Diazepam; Emergency Medical S | 2021 |
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Topics: Animals; Brain Diseases; Cholinesterase Inhibitors; Diazepam; GABA Modulators; Gliosis; Isoflurophat | 2020 |
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA
Topics: Animals; Anticonvulsants; Antidepressive Agents; Binding Sites; Brain; Diazepam; Drug Synergism; Ele | 2020 |
Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol‑kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebellum; Diazepam; Electric Stimulation; Kindling, Neurologic | 2020 |
Lorazepam timing for acute convulsive seizure control (LoTASC).
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Benzodiazepines; Diazepam; Female; Humans; Lorazepam; M | 2020 |
Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish.
Topics: Animals; Anticonvulsants; Diazepam; Female; Locomotion; Male; Particle Size; Pentylenetetrazole; Pro | 2021 |
Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Drug Compounding; Humans; Nasal Cavity; Nasal | 2021 |
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Lo | 2021 |
Blood concentration of levetiracetam after bolus administration in patients with status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Levetiracetam; Piracetam; Seizures; Status Epilepticus | 2021 |
Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: Results from an exit survey of a phase 3, open-label, repeat-dose safety study.
Topics: Administration, Intranasal; Caregivers; Diazepam; Humans; Nasal Sprays; Seizures | 2021 |
The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study.
Topics: Animals; Diazepam; Male; Naloxone; Quercetin; Rats; Rats, Wistar; Seizures; Tramadol | 2021 |
Managing Acute Seizures: New Rescue Delivery Option and Resources to Assist School Nurses.
Topics: Adolescent; Anticonvulsants; Child; Diazepam; Humans; Nurses; School Nursing; Schools; Seizures | 2021 |
Effects of probiotics on pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Diazepam; Mice; Pentylenetetrazole; Probiotics; Seizures | 2021 |
Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting.
Topics: Administration, Buccal; Administration, Rectal; Ambulatory Care; Anticonvulsants; Child; Child, Pres | 2019 |
Nursing a critically ill tetanus patient in an intensive care unit in Zambia.
Topics: Analgesics, Opioid; Anti-Infective Agents; Anticonvulsants; Back Pain; Critical Care Nursing; Critic | 2017 |
Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.
Topics: Administration, Intravenous; Administration, Oral; Anticonvulsants; Blood Pressure; Databases, Factu | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.
Topics: Administration, Oral; Antidotes; Antitubercular Agents; Diazepam; Drug Combinations; Female; Humans; | 2017 |
Midazolam vs diazepam in prolonged seizures in children: A pharmacoeconomic approach.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Decision Trees; | 2018 |
DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Antioxidants; Diazepam; Disease Models, Animal; DNA Damage; Hi | 2018 |
Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Mida | 2018 |
Improved cardiac outcomes with combined atenolol and diazepam intervention in seizure.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Atenolol; Diazepam; Drug Therapy, Combination; Ele | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Pre-hospital ambulance care of patients following a suspected seizure: A cross sectional study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Airway Management; Ambulances; Anticonvulsants; Cross-Se | 2018 |
Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawl | 2018 |
Clarified Açaí (
Topics: Animals; Anticonvulsants; Cells, Cultured; Complex Mixtures; Diazepam; Disease Models, Animal; Euter | 2018 |
Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Chemistry; Cell Death; Cell Survival; Diazepam | 2019 |
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazep | 2018 |
Pronounced antiepileptic activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrocorticography; Electrod | 2019 |
Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar.
Topics: Animals; Anticonvulsants; Astrocytes; Atropine; Brain; Cholinesterase Reactivators; Cholinesterases; | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats.
Topics: Animals; Anticonvulsants; Dapsone; Diazepam; Electroencephalography; Hippocampus; Kainic Acid; Male; | 2019 |
Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.
Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Diazepam; Droperidol; Humans; Male; Problem | 2019 |
[A case of post-cardiac arrest syndrome presenting with lateralized periodic discharges evolving to a cyclic seizure pattern on electroencephalogram].
Topics: Anticonvulsants; Arrhythmias, Cardiac; Coronary Vasospasm; Diazepam; Electroencephalography; Heart A | 2019 |
Treatment of Seizures in Children and Adults in the Emergency Medical System of the City of Zurich, Switzerland - Midazolam vs. Diazepam - A Retrospective Analysis.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Hum | 2019 |
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Elect | 2019 |
GABAB receptors as a common target for hypothermia and spike and wave seizures: intersecting mechanisms of thermoregulation and absence epilepsy.
Topics: Animals; Anticonvulsants; Benzoates; Body Temperature Regulation; Cerebral Cortex; Diazepam; Epileps | 2013 |
Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Female; GABA Modulators; Interneurons; Mice; Mi | 2013 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; GABA Uptake Inhib | 2013 |
Cobalamin deficiency manifested with seizures, mood oscillations, psychotic features and reversible dementia in the absence of typical neurologic and hematologic signs and symptoms: a case report.
Topics: Carbamazepine; Dementia; Diazepam; Electroencephalography; Haloperidol; Hematology; Humans; Hydroxoc | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Midazolam oral transmucosal route. An alternative to rectal diazepam for some children.
Topics: Administration, Buccal; Administration, Rectal; Anticonvulsants; Child; Diazepam; Drug Interactions; | 2013 |
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Topics: Algorithms; Animals; Anticonvulsants; Caregivers; Chromatography, High Pressure Liquid; Clinical Ala | 2013 |
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinic | 2013 |
Seizure activity occurring in two dogs after S-ketamine-induction.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Animals; Anticonvu | 2013 |
The efficacy of sublingual Lorazepam for prolonged convulsions beyond sub-saharan Africa: raising more questions than answers.
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Seizures | 2014 |
Reply to comment on "Efficacy of sublingual Lorazepam for prolonged convulsions beyond sub-Saharan Africa".
Topics: Anticonvulsants; Diazepam; Female; Humans; Lorazepam; Male; Seizures | 2014 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazepam; Electroencephalography; Glucose; | 2013 |
Uncommon acute neurologic presentation of canine distemper in 4 adult dogs.
Topics: Animals; Anticonvulsants; Central Nervous System Viral Diseases; Diazepam; Distemper; Distemper Viru | 2014 |
Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats.
Topics: Animals; Anxiety; Diazepam; GABA-A Receptor Agonists; Male; Motor Activity; Protein Subunits; Rats; | 2014 |
Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Cell Membrane Permeability; Diazepam; Dipeptid | 2014 |
Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.
Topics: Animals; Anticonvulsants; Clomiphene; Convulsants; Diazepam; Disease Models, Animal; Estriol; Female | 2014 |
[Case of an elderly woman with dementia showing episodic involuntary movement of the tongue].
Topics: Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Diagnosis, Differential; Diazepam; Drug Thera | 2014 |
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 2015 |
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio | 2014 |
Risk factors for apnea in children presenting with out-of-hospital seizure.
Topics: Airway Management; Anticonvulsants; Apnea; Child, Preschool; Diazepam; Emergency Medical Services; E | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Lythra | 2015 |
Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Brain Waves; Bridged-Ring Compounds; Diaz | 2014 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Topics: Allylglycine; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Fructose; Levetiracetam; M | 2015 |
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Calcium; Cells, Cultured; Diazepam; Disease Models | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, I | 2015 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonid | 2015 |
Anticonvulsant activity of methanolic extract from Kalanchoe pinnata Lam. stems and roots in mice: A comparison to diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kalanchoe; Male; Methanol; Mice; Mice, Inbr | 2016 |
(1)H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures.
Topics: Animals; Brain; Diazepam; Illicium; Lactones; Male; Metabolomics; Mice; Mice, Inbred ICR; Nuclear Ma | 2016 |
Forebrain-independent generation of hyperthermic convulsions in infant rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Denervation; Diazepam; Disease Models, | 2016 |
Maternal and perinatal outcome of eclampsia over a decade at a tertiary hospital in Kuwait.
Topics: Adolescent; Adult; Anticonvulsants; Diazepam; Female; Humans; Incidence; Infant, Newborn; Kuwait; Lo | 2016 |
Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Bumetanide; Diazepam; Disease Progression; Drug Resistant Epilepsy; | 2016 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
[Comparison of Two Symptom-Triggered Treatments for Alcohol Withdrawal: HAES vs. SAB-P].
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Central Nervous System Depressants; Chlormethi | 2016 |
Characterization of seizures induced by acute exposure to an organophosphate herbicide, glufosinate-ammonium.
Topics: Aminobutyrates; Animals; Anticonvulsants; Astrocytes; Brain; Cerebral Cortex; Diazepam; Electroencep | 2016 |
Four analytically confirmed cases of use of third-generation synthetic cannabinoid receptor agonists incorporating an adamantyl group.
Topics: Adamantane; Cannabinoid Receptor Agonists; Consciousness; Diazepam; Humans; Prisoners; Seizures; Tac | 2016 |
Administration of anticonvulsive rescue medication in children-discrepancies between parents' self-reports and limited practical performance.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anticonvulsants; Child; Diazepam; | 2016 |
Intranasal midazolam for seizure cessation in the community setting.
Topics: Administration, Intranasal; Ambulatory Care Facilities; Anticonvulsants; Child; Diazepam; Humans; Mi | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Local Anesthetics Systemic Toxicity.
Topics: Administration, Intravenous; Adult; Anesthetics, Local; Diazepam; Female; Humans; Lidocaine; Male; M | 2016 |
Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice.
Topics: Animals; Anticonvulsants; Dantrolene; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Pentyl | 2016 |
Clinical Epidemiology and Treatment of Febrile and Afebrile Convulsions With Mild Gastroenteritis: A Multicenter Study.
Topics: Anticonvulsants; Carbamazepine; Diazepam; Female; Fever; Gastroenteritis; Humans; Infant; Linear Mod | 2017 |
Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain.
Topics: Animals; Brain; Diazepam; Mice; Mice, Knockout; Neurotransmitter Agents; Receptors, GABA-A; Seizures | 2017 |
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Bicuculline; Diazepam; Differential Thr | 2008 |
Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Benzoxazines; Cannabinoid | 2008 |
Diazepam protects against the enhanced toxicity of cocaine adulterated with atropine.
Topics: Animals; Anticonvulsants; Atropine; Body Temperature; Cocaine; Diazepam; Dopamine Uptake Inhibitors; | 2008 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Male; Passiflora; Pentylenetet | 2008 |
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Brain; Cholinesterase Inhibitors; Diaze | 2009 |
Treatment of community-onset childhood convulsive status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Injections, Intravenous; Lorazepam | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Administrati | 2009 |
Clinical reasoning: a child with pulsatile headache and vomiting.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Electroencephalography; Headache; Humans; | 2009 |
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
The anxiolytic etifoxine protects against convulsant and anxiogenic aspects of the alcohol withdrawal syndrome in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Ethanol; GABA Agonists; Male; Mice; Models, Animal; | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relation | 2009 |
Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cameroon; Convulsants; Diazepam; Dose-Respon | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Malaria; Male; Midazolam | 2009 |
The interaction of sildenafil with the anticonvulsant effect of diazepam.
Topics: Animals; Anticonvulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; | 2009 |
Ayurvedic processed seeds of nux-vomica: neuropharmacological and chemical evaluation.
Topics: Aloe; Animals; Behavior, Animal; Catalepsy; Central Nervous System Agents; Diazepam; Dietary Fats; F | 2010 |
Effect of repeated administration of Annona diversifolia Saff. (ilama) extracts and palmitone on rat amygdala kindling.
Topics: Administration, Oral; Amygdala; Analysis of Variance; Animals; Annona; Anticonvulsants; Area Under C | 2009 |
Sequential intrarectal diazepam and intravenous levetiracetam in treating acute repetitive and prolonged seizures.
Topics: Acute Disease; Administration, Rectal; Adult; Aged; Diazepam; Drug Therapy, Combination; Female; Hum | 2010 |
Effect of Brewer's yeast-induced pyrexia on aminophylline-elicited convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Apnea; Bronchodilator Agents; Child; Convulsants; Diazepam; | 2009 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kai | 2009 |
Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cath | 2010 |
Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Diazepam; Drug Interactions; Enzyme Assays; | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Clinical reasoning: seizures in a child with sensorineural deafness and agitation.
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Child, Preschool; Diazepam; Electroencephalography; Fe | 2010 |
Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Diazepam; Electroencephalography; Guinea Pigs; Ma | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
Anticonvulsant activity of embelin isolated from Embelia ribes.
Topics: Animals; Anticonvulsants; Benzoquinones; Central Nervous System Depressants; Diazepam; Dose-Response | 2011 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Seizure control.
Topics: Anticonvulsants; Diazepam; Emergency Medical Services; Humans; Seizures | 2010 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
[Status of the medical management of convulsive seizures at regular schools].
Topics: Adolescent; Adult; Anticonvulsants; Child; Diazepam; Faculty; Humans; Nurses; School Health Services | 2010 |
Comparative study of taurine and tauropyrone: GABA receptor binding, mitochondrial processes and behaviour.
Topics: Animals; Behavior, Animal; Bicuculline; Diazepam; Dihydropyridines; Energy Metabolism; Ethanol; Hydr | 2011 |
Cannabis intoxication in three Green iguanas (Iguana iguana).
Topics: Animals; Anticonvulsants; Cannabis; Diazepam; Female; Iguanas; Male; Seizures; Treatment Outcome | 2011 |
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cation Transport Proteins; Diazepam; Disease Models, | 2011 |
Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Child, Preschoo | 2011 |
Antiepileptic effects of endogenous beta-hydroxybutyrate in suckling infant rats.
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Suckling; Anticonvulsants; Brain; Bumetanide; Convulsants; | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures.
Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterase Reactivators; D | 2011 |
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin.
Topics: Amygdala; Animals; Anticonvulsants; Atropine; Cerebral Cortex; Chemical Warfare Agents; Cholinestera | 2011 |
Benzodiazepines in the acute management of seizures with autonomic manifestations: anticipate complications!
Topics: Autonomic Nervous System Diseases; Benzodiazepines; Child; Child, Preschool; Diazepam; Female; Human | 2011 |
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain-Derived Neurotrophic Factor; Convulsants; Diazepa | 2011 |
Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cholinesterase Inhibitors; Diazepam; Disease Models, Anim | 2011 |
Pharmacoresistant convulsions and visual hallucinations around two weeks after selegiline overdose: a case report.
Topics: Anticonvulsants; Bipolar Disorder; Coma; Diazepam; Drug Overdose; Drug Resistance; Hallucinations; H | 2011 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: synergism with the benzodiazepine diazepam.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Body Temperature; Body Weight; Cholinergic Antagonis | 2012 |
Benzodiazepines for acute management of seizures.
Topics: Diazepam; Female; Humans; Lorazepam; Male; Midazolam; Seizures | 2012 |
Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Diazepam; Disease Mo | 2012 |
Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure.
Topics: Animals; Anticonvulsants; Brain; Brain Mapping; Brain Waves; Chemical Warfare Agents; Cytoprotection | 2012 |
Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System; Diazepam; Exploratory Behavior; | 2012 |
Characterization of status epilepticus induced by two organophosphates in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Electroencephalography; Isoflurophate; Male; Ne | 2012 |
[Adrenaline potentiates antiepileptic but not sedative action of diazepam in rats].
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Epinephrine; Gastric Mucosa; Hypnotics and Sedat | 2012 |
Evaluation of the sedative and anticonvulsant properties of three Cameroonian plants.
Topics: Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; Cameroon; Diazepam; Dose-Respo | 2011 |
Synthesis and anticonvulsant activity of O-alkylated derivatives of 1-(2-naphthyl)-2-(imidazol-1-yl)ethanone oxime.
Topics: Alkylation; Animals; Anticonvulsants; Chloroacetates; Diazepam; Imidazoles; Male; Mice; Oximes; Pent | 2012 |
Oromucosal midazolam: a guide to its use in paediatric patients with prolonged acute convulsive seizures.
Topics: Administration, Buccal; Adolescent; Child; Child, Preschool; Diazepam; Humans; Infant; Midazolam; Se | 2012 |
Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohist | 2012 |
Mechanisms of high-dose citalopram-induced death in a rat model.
Topics: Animals; Body Temperature; Citalopram; Cyproheptadine; Diazepam; Dose-Response Relationship, Drug; L | 2012 |
Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook.
Topics: Administration, Oral; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2012 |
Behavioural actions of two new 1-N substituted analogues of melatonin.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antioxidants; Anxiety; Behavior, Animal; Diazepam; Do | 2013 |
Differential antagonism of tetramethylenedisulfotetramine-induced seizures by agents acting at NMDA and GABA(A) receptors.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dizocilpine Maleate; Electroencephalography; Excita | 2012 |
Ecalmpsia: maternal and fetal outcome.
Topics: Adolescent; Adult; Anticonvulsants; Confidence Intervals; Diazepam; Eclampsia; Female; Hospitals, Te | 2012 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Arachidonic Acid; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Diclofenac; Enzyme Inhi | 2012 |
Neuroborreliosis presenting as acute disseminated encephalomyelitis.
Topics: Brain Damage, Chronic; Cefotaxime; Ceftriaxone; Child, Preschool; Coma; Diazepam; Encephalomyelitis, | 2012 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Topics: Amygdala; Animals; Apoptosis; Caspase 6; Caspase 7; Caspases; Convulsants; Diazepam; Electroencephal | 2002 |
Pharmacological antagonism of lethal effects induced by O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Electrocardiography; Electrom | 2002 |
Possible anxiolytic effects of ivermectin in rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Ivermectin; Loco | 2002 |
Respiratory depression in the acute management of seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Chronic Disease; Diazepam; Drug Therapy, Combination; Huma | 2002 |
Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Caffeine; Central Nervous System Stimulants; | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepa | 2002 |
Controlling seizures in the prehospital setting: diazepam or midazolam?
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Medical Services; Female; GABA Modulat | 2002 |
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Topics: Animals; Anticonvulsants; Benzopyrans; Bicuculline; Cassia; Diazepam; Dopamine; Dose-Response Relati | 2002 |
[Convulsions induced by ropivacaine after midhumeral block].
Topics: Amides; Anesthetics, Local; Anticonvulsants; Brachial Plexus; Diazepam; Female; Humans; Humerus; Mid | 2002 |
Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Design; GABA-A Receptor Agonists; Indicators a | 2003 |
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbit | 2003 |
Modulation of development of tolerance to anticonvulsant effect of diazepam by flumazenil.
Topics: Animals; Anticonvulsants; Diazepam; Drug Tolerance; Female; Flumazenil; Male; Mice; Seizures | 2002 |
Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-2 Receptor Antagonists; Animals; Anticonvulsants; Brain; Diaze | 2003 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Mot | 2003 |
Anticonvulsant effect of flutamide on seizures induced by pentylenetetrazole: involvement of benzodiazepine receptors.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug In | 2003 |
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diaze | 2003 |
Long-lasting behavioral changes induced by pre- or neonatal exposure to diazepam in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Diazepam; Female; Male; Pregnancy; Prenatal Exposure De | 2003 |
Chemical anesthesia of northern sea otters (Enhydra lutris): results of past field studies.
Topics: Anesthesia; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Azaperone; Body Temperature; D | 2001 |
Paradoxical therapy in conversion reaction.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety; Anxiety Disorders; Conversion Disorder; Diazepam; Femal | 2003 |
Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
Topics: Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Oleic Acids; Pentylene | 2003 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System | 1963 |
COMPARATIVE STUDY OF CHLORDIAZEPOXIDE AND DIAZEPAM.
Topics: Cerebral Palsy; Chlordiazepoxide; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Int | 1964 |
CONTROL OF THE NEUROMUSCULAR AND CONVULSIVE MANIFESTATIONS OF SEVERE SYSTEMIC TETANUS: CASE REPORT WITH A NEW DRUG, VALIUM (DIAZEPAM).
Topics: Amobarbital; Child; Diazepam; Diphenhydramine; Humans; Neurologic Manifestations; Penicillins; Pheno | 1964 |
DIAZEPAM (VALIUM) IN MYOCLONIC SEIZURES. FAVORABLE RESPONSE DURING INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Diazepam; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Epile | 1965 |
CONVULSIONS IN A PILOT FOLLOWING DRUG WITHDRAWAL.
Topics: Aerospace Medicine; Diazepam; Drug Therapy; Meprobamate; Pentobarbital; Psychoses, Substance-Induced | 1965 |
ANTICONVULSANT PROPERTIES OF SOME BENZODIAZEPINE DERIVATIVES. POSSIBLE USE AGAINST PSYCHOMOTOR SEIZURES.
Topics: Amygdala; Anticonvulsants; Cats; Caudate Nucleus; Cerebral Cortex; Chlordiazepoxide; Cocaine; Diazep | 1965 |
TOXIC PSYCHOSIS WITH TRANSIENT DYSMNESTIC SYNDROME FOLLOWING WITHDRAWAL FROM VALIUM.
Topics: Chlorpromazine; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Hallucinations; Humans; Memory; Psychose | 1965 |
AN EXPERIMENTAL STUDY OF THE ANTICONVULSIVE AND RELAXANT ACTIONS OF VALIUM.
Topics: Acetylcholine; Amygdala; Carbachol; Cats; Diazepam; Electric Stimulation; Electroencephalography; El | 1964 |
Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Protein | 2003 |
Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model.
Topics: Action Potentials; Animals; Bicuculline; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2004 |
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.
Topics: Animals; Anticonvulsants; Benzoquinones; Diazepam; Electroshock; Flumazenil; GABA Modulators; Inject | 2004 |
Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity.
Topics: Animals; Benzodiazepines; Diazepam; Imidazoles; Isoflurophate; Male; Neuroprotective Agents; Rats; R | 2004 |
Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis.
Topics: Anesthetics, Local; Anticonvulsants; Bromazepam; Child, Preschool; Diazepam; Female; Gastroenteritis | 2004 |
Organophosphate-induced convulsions and prevention of neuropathological damages.
Topics: Acetylcholinesterase; Adenosine; Animals; Antidotes; Atropine; Brain; Cholinesterase Inhibitors; Dia | 2004 |
Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse.
Topics: Animals; Anticonvulsants; Apoptosis; Blotting, Western; Caspase 8; Caspases; Diazepam; DNA Fragmenta | 2004 |
Postoperative seizures after sevoflurane anesthesia in a neonate.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2004 |
Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants | 2004 |
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electro | 2004 |
Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats.
Topics: Animals; Chlorides; Chronic Disease; Corticosterone; Diazepam; Ethanol; Female; Male; Rats; Rats, Sp | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phe | 2003 |
Case report: Diazepam in severe tetanus treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Dose-Response Relationship, Drug; Drug Administr | 2004 |
Flunarizine: a possible adjuvant medication against soman poisoning?
Topics: Animals; Atropine; Brain; Calcium Channel Blockers; Chemical Warfare Agents; Diazepam; Drug Therapy, | 2004 |
Mosquito coil (Allethrin) poisoining in two brothers.
Topics: Animals; Child, Preschool; Diazepam; Humans; Injections, Intravenous; Insecticides; Male; Mosquito C | 2004 |
Convulsions with intraurethral instillation of lignocaine.
Topics: Adult; Anesthetics, Local; Anticonvulsants; Diazepam; Humans; Lidocaine; Male; Rectal Neoplasms; Sei | 2005 |
Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain.
Topics: Animals; Atropine; Brain; Diazepam; Drug Therapy, Combination; Electroencephalography; Interleukin-1 | 2005 |
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Chi-Square Distribution; Di | 2005 |
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2005 |
Late postpartum eclampsia as an obstetric complication seen in the ED.
Topics: Adult; Analgesics; Anticonvulsants; Antihypertensive Agents; Blood Pressure Determination; Diazepam; | 2005 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Amiloride protects against pentylenetetrazole-induced kindling in mice.
Topics: Amiloride; Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindli | 2005 |
Neuroprotection from soman-induced seizures in the rodent: evaluation with diffusion- and T2-weighted magnetic resonance imaging.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Cyclohexanes; Cyclohexenes; Diazepam; Diffusion Magneti | 2005 |
Cocaine alters catalase activity in prefrontal cortex and striatum of mice.
Topics: Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Bupropion; Catalase; Catecholamines; Cocaine | 2005 |
Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.
Topics: Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cul | 2005 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
[Choice and administration sequence of antiepileptic agents for status epilepticus and frequent seizures in children].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Female | 2005 |
Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodi | 2005 |
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvuls | 2006 |
Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Ethanol; | 2006 |
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; | 2006 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug In | 2006 |
Anticonvulsant effects of GABA(A) modulators microinfused into area tempestas or substantia nigra in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Chemical Warfare Agents; Diazepam; Drug Therapy, Combinat | 2006 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; | 2006 |
Effect of simultaneous insertion of oleaginous base on the absorption and on the anticonvulsant effect of diazepam suppository.
Topics: Animals; Anticonvulsants; Area Under Curve; Convulsants; Diazepam; Dose-Response Relationship, Drug; | 2006 |
Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.
Topics: Animals; Anticonvulsants; Benzamides; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; El | 2006 |
In vivo characterization of sedative activities of Fossilia Mastodi OSSIS.
Topics: Animals; Diazepam; Fossils; Hypnotics and Sedatives; Male; Mammals; Mice; Mice, Inbred ICR; Motor Ac | 2006 |
Anticonvulsant properties of hypothermia in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Cold Temperature; Dentate Gyrus; Diazepam; Diseas | 2006 |
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.
Topics: Animals; Anticonvulsants; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Disease Models, Animal; | 2006 |
PRES: posterior or potentially reversible encephalopathy syndrome?
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Antihypertensive Agents; Brain; Brain Diseases; Cl | 2006 |
Hyponatraemic convulsions and fatal head injury secondary to desmopressin treatment for enuresis.
Topics: Adult; Anticonvulsants; Antidiuretic Agents; Brain; Brain Edema; Craniocerebral Trauma; Craniotomy; | 2006 |
Community use of intranasal midazolam for managing prolonged seizures.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Aged; Anticonvulsants; Attitu | 2006 |
Anticonvulsants for nerve agent-induced seizures: The influence of the therapeutic dose of atropine.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Dose-Response Relationship, D | 2007 |
Lithium-methomyl induced seizures in rats: a new model of status epilepticus?
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Synergism; Electroencephalography; | 2007 |
Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
Topics: Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Convulsants; Diazepam; Electroshock; GABA- | 2007 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Effects of toluene exposure during brain growth spurt on GABA(A) receptor-mediated functions in juvenile rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Diazepam; Electric Stimulation; GABA Agonists; G | 2007 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
Serial-probe recognition in rhesus macaques: effects of midazolam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Macaca mulatta; Male; Memory, Short-Term; Midaz | 2006 |
Nalidixic acid overdose and metabolic acidosis.
Topics: Acidosis; Adolescent; Anti-Infective Agents; Anticonvulsants; Cognition Disorders; Diazepam; Drug Ov | 2006 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Single-dose chloral hydrate for benign convulsions with mild gastroenteritis.
Topics: Anticonvulsants; Child, Preschool; Chloral Hydrate; Comorbidity; Diazepam; Dose-Response Relationshi | 2007 |
Prehospital intranasal midazolam for the treatment of pediatric seizures.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Presc | 2007 |
Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats.
Topics: Amygdala; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Calcium; Cell Count; Cell Size; Diazepam | 2007 |
First-line therapy for theophylline-associated seizures.
Topics: Age of Onset; Animals; Anticonvulsants; Barbiturates; Brain Damage, Chronic; Child; Child, Preschool | 2007 |
Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.
Topics: Animals; Anticonvulsants; Clorazepate Dipotassium; Convulsants; Diazepam; Macaca mulatta; Pentylenet | 1974 |
Interaction of diazepam and swim stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationsh | 2007 |
Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Evaluat | 2008 |
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models | 2008 |
Ketamine in the management of generalised cephalic tetanus.
Topics: Anticonvulsants; Diazepam; Disease Progression; Female; Humans; Ketamine; Otitis Externa; Otitis Med | 2008 |
Stesolid emergency treatment: cave social fear!
Topics: Administration, Rectal; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Consciousness; | 2008 |
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Topics: Acetylcholine; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Cholinesterases; Diazepa | 2007 |
[Treatment for seizures during theophylline medication].
Topics: Anticonvulsants; Barbiturates; Bronchodilator Agents; Child, Preschool; Diazepam; Drug Resistance; H | 2008 |
[Case of serious lidocaine intoxication].
Topics: Anesthetics, Local; Atropine; Brachial Plexus; Cardiac Pacing, Artificial; Diazepam; Heart Arrest; H | 2008 |
Jacksonian seizure in a manic patient treated with rTMS.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Diazepam; Electroencephalography; Female; Humans; Seizures | 2008 |
Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarb | 2008 |
Sequential magnetic resonance imaging changes after suspected global brain ischaemia in a dog.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Apnea; Bradycardia; Brain; Brain Isc | 2008 |
[Effect of diazepam pretreatment on convulsions induced by procaine].
Topics: Animals; Diazepam; Injections, Intraperitoneal; Pentobarbital; Procaine; Rats; Seizures | 1966 |
[Experimental contribution to the study of antiepileptic effects of benzodiazepines (Valium and Mogadan)].
Topics: Action Potentials; Amygdala; Animals; Brain; Cats; Cerebral Cortex; Diazepam; Electroencephalography | 1967 |
Protective effects of diazepam and valproate on beta-vinyllactic acid-induced seizures.
Topics: Animals; Brain; Convulsants; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gl | 1984 |
Inhibition of seizures induced by picrotoxin and electroshock by cholecystokinin octapeptides and their fragments in rats after intracerebroventricular administration.
Topics: Animals; Anticonvulsants; Diazepam; Electroshock; Injections, Intraventricular; Male; Peptide Fragme | 1984 |
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Toleranc | 1984 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; C | 1984 |
Brain cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Brain; Bucladesine; Cyclic AMP; Cyclic GMP; Diazepam; Dibutyryl Cyclic GMP | 1984 |
Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor.
Topics: Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membra | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
Brain-specific benzodiazepine receptors and putative endogenous benzodiazepine-like compounds.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Chromatography, Gel; Diazepam; Hypoxanthi | 1980 |
Febrile convulsions: a suitable case for treatment?
Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Risk; Seizures; Seizures, Febrile | 1980 |
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Binding Sites; Brain; Diazepam; Flunitrazepam; g | 1980 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Th | 1981 |
Aminophylline seizures in the rat.
Topics: Aminophylline; Animals; Diazepam; Male; Phenobarbital; Phenytoin; Rats; Seizures | 1981 |
Intravenous regional conduction anesthesia: a technique and literature review-part I.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, Intravenous; Diazepam; Humans; Neural Conduc | 1981 |
[Anxiety receptors: new pharmacological approach (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlo | 1982 |
Some behavioral effects of chlorodesmethyldiazepam and lorazepam.
Topics: Acoustic Stimulation; Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; D | 1981 |
The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices.
Topics: Acetylcholine; Animals; Anticonvulsants; Cerebral Cortex; Culture Techniques; Diazepam; gamma-Aminob | 1982 |
Flunitrazepam protects mice against lidocaine and bupivacaine-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bupivacaine; Diazepam; Dose-Response Relationship, Dr | 1983 |
A comparison of flunitrazepam and diazepam in the prevention of local anesthetic-induced convulsions.
Topics: Animals; Anti-Anxiety Agents; Bupivacaine; Diazepam; Female; Flunitrazepam; Lidocaine; Mice; Seizure | 1983 |
Effects of new benzodiazepine estazolam on ECOG pattern and maximal electroshock (MES) in the rat.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Electroshock; Estazolam; Flunitrazepam; Mal | 1983 |
Physical dependence on diazepam and lorazepam in the dog.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dogs; Female; Gait; Humans; Lorazepam; Pyrazole | 1983 |
Modification of seizures elicited by the benzodiazepine Ro 5-3663--a comparison with picrotoxin.
Topics: Animals; Benzodiazepinones; Chemical Phenomena; Chemistry; Convulsants; Diazepam; Drug Synergism; Fl | 1984 |
Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Psychological; Diazepam; Drinking Beha | 1984 |
Cumulative after-discharge as the principal factor in the acquisition of kindled seizures.
Topics: Animals; Brain; Diazepam; Male; Phenobarbital; Propranolol; Rats; Seizures | 1981 |
Pharmacological aspects of metaldehyde poisoning in mice.
Topics: Acetaldehyde; Animals; Brain; Clonidine; Diazepam; Female; Hydroxyindoleacetic Acid; Male; Mice; Mic | 1982 |
The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state.
Topics: Animals; Anticonvulsants; Bemegride; Brain; Diazepam; Drug Evaluation, Preclinical; Fatty Acids, Non | 1984 |
[Participation of GABA-ergic structures in producing the effects of haloperidol].
Topics: Animals; Bicuculline; Chlorpromazine; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Ra | 1980 |
Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Ceruletide; Cholecystokinin; Diazepam; Kinetics; Male; Mice; | 1980 |
[Electrical activity and Na, K-ATPase levels in an epileptic focus caused by application of penicillin to rat cerebral cortex and the effect of diazepam on them].
Topics: Animals; Cerebral Cortex; Diazepam; Electrophysiology; Male; Penicillins; Rats; Seizures; Sodium-Pot | 1980 |
beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Diazepam; Drug Synergism; Indoles; Membranes; Pent | 1980 |
Cefazolin experimental epilepsy: the effects of diazepam on the interictal ECoG.
Topics: Animals; Cefazolin; Chickens; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Injections, | 1980 |
An endogenous substance from porcine brain antagonizes the anticonvulsant effect of diazepam.
Topics: Animals; Anticonvulsants; Brain; Diazepam; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Receptors | 1981 |
Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Binding, Competitive; Diazepam; Hypoxanthines; Inosine; Kynurenine; Ligand | 1981 |
Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid.
Topics: Animals; Anticonvulsants; Ceruletide; Cholecystokinin; Diazepam; Haloperidol; Harmine; Isoniazid; Ma | 1981 |
Treatment of imipramine overdose in children.
Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat | 1981 |
[Effect of diazepam on cyclic changes in the excitability and status of Na, K-ATPase in an epileptic focus].
Topics: Animals; Cerebral Cortex; Diazepam; Male; Rats; Seizures; Sodium-Potassium-Exchanging ATPase | 1981 |
Exsanguination from rupture of an occult hepatoma in a comatose patient: case report.
Topics: Aged; Carcinoma, Hepatocellular; Coma; Diazepam; Female; Hemorrhage; Humans; Injections, Intravenous | 1981 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Re | 1981 |
Caerulein and cholecystokinin octapeptide (CCK-8): sedative and anticonvulsive effects in mice unaffected by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Blepharoptosis; Body Temperature; Ceruletide; Cholecyst | 1982 |
Using Ro 15-1788 to investigate the benzodiazepine receptor in vivo: studies on the anticonvulsant and sedative effect of melatonin and the convulsant effect of the benzodiazepine Ro 05-3663.
Topics: Animals; Arousal; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Exploratory | 1982 |
Role of benzodiazepine receptors in seizures.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Diazepam; Hypoxanthines; Inosine; Mice; Penty | 1983 |
Nonketotic hyperglycinemia: treatment with diazepam--a competitor for glycine receptors.
Topics: Binding, Competitive; Choline; Diazepam; Electroencephalography; Female; Folic Acid; Glycine; Humans | 1983 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitraze | 1983 |
The benzodiazepine receptor and receptor tolerance produced by chronic treatment of diazepam.
Topics: Animals; Anticonvulsants; Brain; Calcium; Diazepam; Drug Tolerance; Electroshock; Male; Rats; Rats, | 1983 |
Benzodiazepine receptor declines in hippocampal formation following limbic seizures.
Topics: Afferent Pathways; Animals; Diazepam; Dominance, Cerebral; Flunitrazepam; Hippocampus; Limbic System | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mic | 1983 |
Diazepam, pentobarbital and D-etomidate produced increases in bicuculline seizure threshold; selective antagonism by RO15-1788, picrotoxin and (+/-)-DMBB.
Topics: Animals; Barbiturates; Benzodiazepinones; Bicuculline; Diazepam; Etomidate; Flumazenil; Imidazoles; | 1983 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion | 1984 |
Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.
Topics: Animals; Brain; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Mice; Motor Acti | 1984 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; M | 1984 |
A benzodiazepine antagonist action of CL 218,872.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Convulsants; Diazepam; Flumazenil; Mal | 1984 |
Possible mechanism of digoxin-induced convulsions.
Topics: Animals; Calcium Chloride; Clonidine; Diazepam; Digoxin; Female; gamma-Aminobutyric Acid; Magnesium; | 1983 |
Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Drug Synerg | 1983 |
A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Kindling, Neur | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Rec | 1983 |
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions.
Topics: Animals; Anticonvulsants; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, I | 1983 |
Antagonism of caffeine-induced seizures in mice by Ro15-1788.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Caffeine; Diazepam; Female; Flumazenil; Mice; Receptors | 1984 |
Anticonvulsant potency of common antiepileptic drugs in the gerbil.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Female; Gerbillinae; Male; Phenobar | 1983 |
Anticonvulsant and antipunishment effects of toluene.
Topics: Animals; Benzodiazepinones; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug | 1984 |
Development of tolerance to the anticonvulsant effect of diazepam in dogs.
Topics: Animals; Anticonvulsants; Diazepam; Dogs; Drug Tolerance; Electrocardiography; Electroencephalograph | 1984 |
[Interaction of kynurenine and diazepam].
Topics: Animals; Benzoates; Caffeine; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; D | 1984 |
The bicuculline-like properties of dopamine sulfate in rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Male; M | 1984 |
Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography.
Topics: Adolescent; Adult; Brain Neoplasms; Contrast Media; Diazepam; Drug Evaluation; Female; Glioma; Human | 1984 |
Hippocampal calcium-binding protein during commissural kindling-induced epileptogenesis: progressive decline and effects of anticonvulsants.
Topics: Animals; Calcium-Binding Proteins; Diazepam; Hippocampus; Kindling, Neurologic; Male; Pentylenetetra | 1984 |
The social, psychological and medical management of intoxication.
Topics: Arrhythmias, Cardiac; Delusions; Diazepam; Hallucinations; Hallucinogens; Humans; Hypnotics and Seda | 1984 |
[Cerebral seizures during peridural anaesthesia (systemic reaction following bupivacaine 0.75%)].
Topics: Adult; Anesthesia, Epidural; Bupivacaine; Diazepam; Epinephrine; Humans; Male; Seizures | 1983 |
Local anesthetic toxicity: review and case studies.
Topics: Adolescent; Adult; Anesthetics, Local; Bupivacaine; Cardiovascular System; Central Nervous System; D | 1983 |
Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cefazolin; Cephaloridine; Diazepam; Electroencephalograp | 1983 |
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.
Topics: Animals; Diazepam; Drug Tolerance; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Myoclonus; Pentylen | 1983 |
Strain differences in susceptibility to the convulsant actions of 3-carbomethoxy-beta-carboline.
Topics: Animals; Brain; Carbolines; Convulsants; Diazepam; Disease Susceptibility; Indoles; Male; Mice; Mice | 1983 |
Behavioral comparison of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Chlordiazepoxide; Clonidine; Diazepam; Mot | 1983 |
Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mutant mice by diazepam.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Mice; Mi | 1983 |
Comparison of effects of diazepam on barbiturate and on ethanol withdrawal.
Topics: Animals; Behavior, Animal; Cats; Diazepam; Disease Models, Animal; Ethanol; Female; Humans; Male; Pe | 1983 |
[Midazolam. Chemical data and experimental neuropharmacology].
Topics: Anesthetics; Animals; Benzodiazepines; Central Nervous System Agents; Chemical Phenomena; Chemistry; | 1984 |
Effects on EEG of the osmotic opening of the blood-brain barrier in rats.
Topics: Animals; Blood-Brain Barrier; Diazepam; Electroencephalography; Evans Blue; Male; Mannitol; Osmosis; | 1980 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; | 1981 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ethosuximide; Guinea Pigs; Hippocampus; | 1982 |
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa | 1982 |
Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Disease Models, Animal; Dose-Respon | 1982 |
Blockade of 3-carbomethoxy-beta-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216.
Topics: Animals; Benzodiazepinones; Carbolines; Convulsants; Diazepam; Dose-Response Relationship, Drug; Flu | 1982 |
Methyl-beta-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-beta-carboline.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Flumazenil; Indoles; Papio; Photosensitivity Disor | 1982 |
Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: a double dissociation.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Phenytoin; Rats; Seizures | 1983 |
Inosine, hypoxanthine, and seizures.
Topics: Animals; Brain; Diazepam; Electroshock; Hypoxanthines; Inosine; Mice; Seizures | 1983 |
General principles of treatment: status epilepticus in neonates.
Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital | 1983 |
The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats.
Topics: Amygdala; Animals; Diazepam; Doxapram; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital | 1983 |
Amoxapine intoxication in an infant: seizures arrested with diazepam.
Topics: Accidents, Home; Amoxapine; Diazepam; Dibenzoxazepines; Humans; Infant; Male; Seizures | 1983 |
Tofizopam enhances the action of diazepam against tremor and convulsions.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Interactions; Electroshock; Harmine; M | 1983 |
Effect of diphenylhydantoin with diazepam on electroseizure and chemoseizure susceptibility in mice.
Topics: Animals; Anticonvulsants; Diazepam; Electroshock; Male; Mice; Phenytoin; Seizures | 1983 |
Development of epileptic activity and its correlation with GABAergic and glutamergic systems during brain maturation in the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Diazepam; Electrophysiology; gamma-Aminobutyric | 1983 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.
Topics: Amygdala; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Disease Models, Animal; Electroshock; | 1980 |
Differential effects of diazepam (valium) on brain stimulation reward sites.
Topics: Animals; Diazepam; Electric Stimulation; Electroencephalography; Hippocampus; Male; Rats; Reward; Se | 1982 |
Diazepam withdrawal seizures.
Topics: Adult; Diazepam; Female; Humans; Male; Phenobarbital; Seizures; Substance Withdrawal Syndrome | 1982 |
Hippocampal kindling and effects of antiepileptic drugs.
Topics: Amitriptyline; Amygdala; Animals; Anticonvulsants; Chlorpromazine; Diazepam; Electric Stimulation; E | 1982 |
Therapeutics of monomethylhydrazine intoxication.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Methylhydrazin | 1982 |
Anticonvulsant action of phenobarbital, diazepam, carbamazepine, and diphenylhydantoin in the electroshock test in mice after lesion of hippocampal pyramidal cells with intracerebroventricular kainic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Electroshock; Hippocampus; Injections, Intraventr | 1982 |
Interaction of diazepam with meperidine or normeperidine on analgesia and lethality.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Meperidine; Nociceptor | 1982 |
Health care in jails: a unique challenge in medical practice.
Topics: Adult; Alcoholism; Cannabis; Diazepam; Ethics, Medical; Female; Health Services; Heroin; Humans; Mal | 1982 |
Neonatal convulsions treated with continuous, intravenous infusion of diazepam.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusions, Parenteral; Male; S | 1982 |
Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity.
Topics: Acetaldehyde; Animals; Brain Chemistry; Clonidine; Diazepam; Female; gamma-Aminobutyric Acid; Male; | 1982 |
Dangers of intravenous Diazepam in controlling fits in patients with raised intracranial pressure.
Topics: Child; Child, Preschool; Diazepam; Humans; Injections, Intravenous; Intracranial Pressure; Respirato | 1982 |
Effect of antiepileptic drugs and an anticonvulsant on epileptiform activity induced by antibodies to ganglioside.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, | 1982 |
Isoniazid poisoning in a dog.
Topics: Animals; Diazepam; Dog Diseases; Dogs; Fluid Therapy; Isoniazid; Male; Pentobarbital; Seizures | 1982 |
Benzodiazepines protect mice from local anesthetic convulsions and deaths.
Topics: Anesthetics; Animals; Benzodiazepines; Bupivacaine; Diazepam; Drug Interactions; Etidocaine; Female; | 1981 |
Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: comparison with various anticonvulsants and GABAmimetics.
Topics: Animals; Aporphines; Baclofen; Behavior, Animal; Choline O-Acetyltransferase; Corpus Striatum; Diaze | 1980 |
The anticonvulsant properties of melatonin on kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Penty | 1981 |
Some practical hints and management of convulsions occurring in infancy and children.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Infant, Newborn; Seizu | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Pentylenetetrazole; Phenob | 1981 |
Hydroxyzine intoxication in a 13-month-old child.
Topics: Diazepam; Female; Humans; Hydroxyzine; Infant; Physostigmine; Seizures; Tachycardia | 1981 |
Diphenylhydantoin potentiates the protective effect of diazepam against pentylenetetrazol but not against bicuculline and isoniazid-induced seizures in mice.
Topics: Animals; Bicuculline; Diazepam; Drug Synergism; Isoniazid; Male; Mice; Pentylenetetrazole; Phenytoin | 1981 |
[The treatment of febrile convulsions].
Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Rectum; Seizures; Seizures, Febrile | 1981 |
Effect of diazepam alone and in combination with chlorpromazine or propranolol in experimentally induced convulsions in mice.
Topics: Animals; Chlorpromazine; Diazepam; Drug Therapy, Combination; Electroshock; Male; Mice; Pentylenetet | 1981 |
Management of pre-eclampsia and eclampsia.
Topics: Bed Rest; Delivery, Obstetric; Diazepam; Eclampsia; Female; Fetal Monitoring; Humans; Hypertension; | 1981 |
Behavioral effects following chronic treatment with clomethiazole, pentobarbital and diazepam in the rat.
Topics: Animals; Behavior, Animal; Chlormethiazole; Circadian Rhythm; Diazepam; Hypnotics and Sedatives; Mal | 1981 |
[Effect of stimulation of the paleocerebellar cortex on the multifocal cortical epileptogenic complex].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Cats; Cerebellar | 1981 |
Acute isoniazid poisoning in children.
Topics: Acute Disease; Child, Preschool; Coma; Diazepam; Female; Humans; Isoniazid; Pyridoxine; Seizures | 1981 |
Treatment of febrile seizures.
Topics: Child, Preschool; Diazepam; Female; Humans; Male; Patient Compliance; Seizures; Seizures, Febrile | 1980 |
Lidocaine ingestion.
Topics: Diazepam; Female; Humans; Infant; Lidocaine; Respiratory Insufficiency; Seizures | 1980 |
The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid.
Topics: Afferent Pathways; Amygdala; Animals; Brain; Brain Mapping; Corpus Striatum; Diazepam; Dominance, Ce | 1980 |
The first year of life. Convulsions in the older infant.
Topics: Diazepam; First Aid; Humans; Hyaluronoglucosaminidase; Infant; Paraldehyde; Phenobarbital; Seizures; | 1980 |
Childhood convulsions in the tropics.
Topics: Child, Preschool; Chloral Hydrate; Diazepam; Humans; Infant; Medicine, Traditional; Rural Health; Se | 1980 |
Antagonism of intravenous cocaine lethality in nonhuman primates.
Topics: Animals; Behavior, Animal; Chlorpromazine; Cocaine; Diazepam; Hemodynamics; Infusions, Parenteral; M | 1980 |
Systemic dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic acid.
Topics: Animals; Behavior, Animal; Diazepam; Hippocampus; Kainic Acid; Male; Piperidines; Pyrrolidines; Rats | 1980 |
Delayed diazepam withdrawal syndrome: a case of auditory and visual hallucinations and seizures.
Topics: Diazepam; Hallucinations; Humans; Male; Middle Aged; Seizures; Substance Withdrawal Syndrome | 1980 |
[Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)].
Topics: Acute Kidney Injury; Adolescent; Adult; Brain Edema; Critical Care; Diazepam; Dihydralazine; Eclamps | 1980 |
[Formation of an epileptic complex in the cerebral cortex and effect of diazepam on it with different levels of cerebral transection].
Topics: Acute Disease; Animals; Cats; Cerebral Cortex; Decerebrate State; Diazepam; Electrophysiology; Seizu | 1980 |
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures | 1980 |
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobar | 1980 |
[Effect of diazepam on cyclic changes in excitability in cortical epileptic foci].
Topics: Animals; Diazepam; Electric Stimulation; Evoked Potentials; Male; Motor Cortex; Neural Pathways; Pen | 1980 |
Pharmacological modification of amygdaloid-kindled seizures.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Electrodes, Implanted; Ketamine; Male; Phenobarbi | 1980 |
Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Carbolines; Diazepam; Disease Models, Animal; Drug Tole | 1995 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Spr | 1995 |
aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures.
Topics: Animals; Base Sequence; Diazepam; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Hippocampu | 1994 |
Nitric oxide promotes seizure activity in kainate-treated rats.
Topics: Amino Acid Oxidoreductases; Animals; Diazepam; Ditiocarb; Indazoles; Iron; Kainic Acid; Male; Nitric | 1994 |
Anticonvulsant, anxiolytic and discriminative effects of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX).
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Diazepam; Excitatory Amino Acid | 1995 |
Pentylenetetrazol-induced kindling in animals: protective effect of BR-16A.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Female; Kindling, Neurologic; Male; Mice; Mice, Inb | 1995 |
Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Heart; Male; Myocardium; Neuroprotective Agents | 1995 |
Isoniazid-associated rhabdomyolysis.
Topics: Adolescent; Charcoal; Chemical and Drug Induced Liver Injury; Diazepam; Female; Humans; Isoniazid; P | 1995 |
Central nervous system activity of Rhazya stricta (Decne) in mice.
Topics: Abdomen; Analgesia; Animals; Behavior, Animal; Body Temperature; Central Nervous System; Cimetidine; | 1995 |
Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam.
Topics: Animals; Diazepam; Disease Models, Animal; Epilepsy, Tonic-Clonic; Hydrogen-Ion Concentration; Loraz | 1995 |
Observations of novel behaviors as indices of ethanol withdrawal-induced anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Ethanol; Exploratory Behavior; | 1993 |
Response to glucagon in imipramine overdose.
Topics: Adult; Diazepam; Drug Overdose; Electrocardiography; Female; Glucagon; Humans; Imipramine; Infusions | 1995 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphin | 1994 |
The effects of GABAB ligands on alcohol withdrawal in mice.
Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; GA | 1994 |
Influence of chronic aminophylline on antielectroshock activity of diazepam and aminophylline-induced convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Diazepam; Drug Interactions; Electroshock; Male; Mice; Seiz | 1994 |
Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Diazepam; Ethanol; Female; Flumazenil; Handling, Psycholo | 1994 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice | 1994 |
Effects of the non-NMDA antagonists NBQX and the 2,3-benzodiazepine GYKI 52466 on different seizure types in mice: comparison with diazepam and interactions with flumazenil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Dose-Response Relationship | 1994 |
Gender differences in diazepam withdrawal syndrome in mice.
Topics: Animals; Body Weight; Castration; Diazepam; Disease Models, Animal; Estrogens; Female; Flumazenil; I | 1994 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
A system for testing the development and reversal of anticonvulsant tolerance to benzodiazepines in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Drug Tolerance; Flumazenil; Flu | 1993 |
Chronic pharmacological activities of the novel anxiolytic beta-carboline abecarnil in rats.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Drinking Behavior; Male; Memory; Pentylenetetraz | 1994 |
Comparison of anticonvulsant tolerance, crosstolerance, and benzodiazepine receptor binding following chronic treatment with diazepam or midazolam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Binding, Competitive; Brain; Diazepam; Drug Tolerance | 1994 |
The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam.
Topics: Animals; Behavior, Animal; Cycloserine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, D | 1994 |
Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine.
Topics: Animals; Cerebral Cortex; Diazepam; Dizocilpine Maleate; Hippocampus; Lithium; Male; Pilocarpine; Ra | 1994 |
Cross-substitution of diazepam for barbital results in only a low incidence of audiogenic seizures upon withdrawal in dependent rats.
Topics: Acoustic Stimulation; Animals; Barbital; Diazepam; Male; Rats; Rats, Sprague-Dawley; Seizures; Subst | 1994 |
Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice.
Topics: Animals; Arousal; Avoidance Learning; Carbolines; Convulsants; Diazepam; Exploratory Behavior; Femal | 1994 |
[Effect of sodium valproate, phenobarbital and diazepam during their combined use on convulsions induced by electroshock in mice].
Topics: Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Electroshock; Mice; Phenobarbital; Sei | 1993 |
Efficacy comparison of scopolamine and diazepam against soman-induced debilitation in guinea pigs.
Topics: Animals; Diazepam; Guinea Pigs; Male; Models, Statistical; Scopolamine; Seizures; Soman | 1994 |
Efficacy of injectable anticholinergic drugs against soman-induced convulsive/subconvulsive activity.
Topics: Animals; Diazepam; Guinea Pigs; Injections, Intramuscular; Male; Parasympatholytics; Random Allocati | 1994 |
Seizure after reversal of benzodiazepine treatment with flumazenil: a report of two cases.
Topics: Aged; Diazepam; Female; Flumazenil; Humans; Male; Middle Aged; Receptors, GABA; Seizures | 1994 |
Long-term treatment with abecarnil does not induce diazepam-like dependence in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Electromyography; Male; Mice; Receptors | 1993 |
Transient impairment of the gabaergic function during initiation of soman-induced seizures.
Topics: Animals; Autoradiography; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1993 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine M | 1993 |
Flumazenil induces seizures and death in mixed cocaine-diazepam intoxications.
Topics: Animals; Cocaine; Diazepam; Electroencephalography; Flumazenil; Male; Rats; Rats, Sprague-Dawley; Se | 1994 |
Diazepam potentiation by glycine in pentylenetetrazol seizures is antagonized by 7-chlorokynurenic acid.
Topics: Animals; Diazepam; Drug Synergism; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pent | 1994 |
Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats.
Topics: Animals; Brain; Diazepam; Dipeptides; Molecular Structure; Prodrugs; Rats; Rats, Sprague-Dawley; Sei | 1993 |
Electrical kindling is associated with increases in amygdala acetylcholine levels: an in vivo microdialysis study.
Topics: Acetylcholine; Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Microd | 1994 |
Lesions of the pedunculopontine tegmental nucleus block drug-induced reinforcement but not amphetamine-induced locomotion.
Topics: Amphetamine; Analysis of Variance; Animals; Brain Mapping; Conditioning, Operant; Diazepam; Infusion | 1994 |
Effects of Ca2+ channel blockers on physical dependence on diazepam in mice.
Topics: Animals; Brain; Calcium Channel Blockers; Carbolines; Diazepam; Diltiazem; Drug Interactions; Flunar | 1993 |
Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain.
Topics: Animals; Blotting, Northern; Carrier Proteins; Diazepam; Electroshock; Gene Expression Regulation; G | 1993 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
Acute cocaine toxicity: the effect of agents in non-seizure-induced death.
Topics: Animals; Anticonvulsants; Cocaine; Diazepam; Electrodes, Implanted; Electroencephalography; Male; Ni | 1993 |
Influence of prophylactic anticonvulsant therapy on high-dose busulphan kinetics.
Topics: Adult; Bone Marrow Transplantation; Busulfan; Combined Modality Therapy; Diazepam; Drug Interactions | 1993 |
Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Keta | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; M | 1993 |
Brain abscess in a goat.
Topics: Animals; Ataxia; Brain; Brain Abscess; Cerebellar Diseases; Corynebacterium Infections; Corynebacter | 1993 |
Neurologic dysfunction associated with hypernatremia and dietary indiscretion in Vietnamese pot bellied pigs.
Topics: Animal Feed; Animals; Diazepam; Female; Fluid Therapy; Hypernatremia; Nervous System Diseases; Seizu | 1994 |
Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation.
Topics: Animals; Diazepam; Ethanol; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Re | 1993 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Ele | 1993 |
Low neurotoxicity of LJC 10,627, a novel 1 beta-methyl carbapenem antibiotic: inhibition of gamma-aminobutyric acidA, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Central Nervous System Diseases; Diazepam; GABA-A R | 1993 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psy | 1993 |
The anticonvulsant effects of propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat.
Topics: Animals; Anticonvulsants; Diazepam; Female; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Seizur | 1993 |
Effect of CNS depressant drugs on acute intoxication from Palicourea marcgravii St Hill in rats.
Topics: Animals; Central Nervous System Depressants; Chloral Hydrate; Diazepam; Drug Combinations; Male; Pla | 1993 |
MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.
Topics: Animals; Atropine; Diazepam; Dizocilpine Maleate; Drug Synergism; Electroencephalography; Limbic Sys | 1993 |
Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Bicuculline; Blotting, Northern; Corticosterone; De | 1993 |
Pharmacological modulation of soman-induced seizures.
Topics: Animals; Anticonvulsants; Atropine; Behavior, Animal; Benactyzine; Diazepam; Dizocilpine Maleate; El | 1993 |
Search for an antidote to electroconvulsion and lethality in aminophylline-sensitized mice.
Topics: Aminophylline; Animals; Diazepam; Dizocilpine Maleate; Electroshock; Male; Mice; Seizures; Valproic | 1993 |
Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbolines; Convulsants; Diazepam; Dose-Response Relation | 1995 |
Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam.
Topics: Animals; Anticonvulsants; Aziridines; Diazepam; Male; Rats; Rats, Wistar; Seizures; Triazolam | 1995 |
Diazepam prevents progression of kindled alcohol withdrawal behaviour.
Topics: Animals; Behavior, Animal; Diazepam; Ethanol; Kindling, Neurologic; Male; Rats; Rats, Wistar; Seizur | 1995 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Diazepam; Down-Regulation; Drug Tolerance; F | 1996 |
Lamotrigine potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Diazepam; Drug Synergism; Female; Lamotrigine; Male; | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diaze | 1996 |
Intracerebroventricular pertussis toxin enhances sensitivity to chemical convulsants and decreases the protective efficacy of carbamazepine in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Drug Synergism; GTP-Binding Proteins | 1996 |
Eclampsia--are we doing enough?
Topics: Adult; Anticonvulsants; Diazepam; Eclampsia; Female; Humans; Incidence; Infant, Newborn; Infant, New | 1995 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba | 1996 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Abecarnil, a beta-carboline derivative, does not exhibit anticonvulsant tolerance or withdrawal effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Binding Sites; Carbolines; Convulsants; | 1996 |
Clinical management and outcome of cats with seizure disorders: 30 cases (1991-1993).
Topics: Administration, Oral; Animals; Anticonvulsants; Cat Diseases; Cats; Dexamethasone; Diazepam; Follow- | 1997 |
Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures.
Topics: Animals; Cats; Diazepam; Electroencephalography; Epilepsy; Fentanyl; Limbic System; Male; Mesencepha | 1996 |
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; | 1995 |
Sex differences in bicuculline-induced convulsions: interaction with stress and ligands of benzodiazepine binding sites.
Topics: Animals; Benzodiazepines; Bicuculline; Binding Sites; Cold Temperature; Diazepam; Differential Thres | 1997 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures.
Topics: Adult; Anticonvulsants; Brain; Cerebrovascular Circulation; Delta Rhythm; Depression; Diagnosis, Dif | 1997 |
Anxiolytic-like effects of PNU-101017, a partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Cells, Cultured; Cerebellum; Conflict, Psychologic | 1997 |
Antagonism of soman-induced convulsions by midazolam, diazepam and scopolamine.
Topics: Animals; Anticonvulsants; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Convulsants; Di | 1997 |
Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors.
Topics: Animals; Benzodiazepines; Dentate Gyrus; Diazepam; Electric Conductivity; Female; GABA-A Receptor An | 1997 |
[The effect of aminooxyacetic acid on the antidote activity of diazepam after exposure to GABA-lytics].
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Drug Interactions; GABA Agents; Male; Mice; | 1994 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Aci | 1998 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11.
Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Choli | 1998 |
Tris(2-chloroethyl)phosphate increases ambulatory activity in mice: pharmacological analyses of its neurochemical mechanism.
Topics: Animals; Anti-Anxiety Agents; Brain; Diazepam; Drug Combinations; Flame Retardants; GABA Agonists; G | 1998 |
[Afebrile seizures in rotavirus gastroenteritis].
Topics: Anticonvulsants; Diazepam; Gastroenteritis; Humans; Infant; Male; Rotavirus Infections; Seizures | 1997 |
Refractory status epilepticus in children: role of continuous diazepam infusion.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, Intravenous; | 1998 |
Sensitisation of withdrawal signs following repeated withdrawal from a benzodiazepine: differences between measures of anxiety and seizure sensitivity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Conflict, Psychological | 1998 |
Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors.
Topics: Animals; Anticonvulsants; Carbolines; Cerebral Cortex; Convulsants; Diazepam; Dizocilpine Maleate; M | 1998 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino A | 1998 |
Role of nitric oxide in the hypersusceptibility to pentylenetetrazole-induced seizure in diazepam-withdrawn mice.
Topics: Animals; Arginine; Diazepam; Enzyme Inhibitors; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nit | 1998 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Toleran | 1998 |
Unexplained physical symptoms in dental patients.
Topics: Adult; Anesthesia, Dental; Anticonvulsants; Conscious Sedation; Dental Care; Diagnosis, Differential | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid.
Topics: Analysis of Variance; Animals; Diazepam; Enzyme Induction; gamma-Aminobutyric Acid; Glutamate Decarb | 1998 |
Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Desoxycorticosterone; Diazepam; | 1998 |
Sensitivity of the rat hippocampal GABA(A) receptor alpha 4 subunit to electroshock seizures.
Topics: Animals; Diazepam; Electroshock; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; R | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Opioid receptor mediated anticonvulsant effect of pentazocine.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relati | 1998 |
Pharmacoeconomic considerations in treatment options for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical | 1998 |
Bupivacaine-induced seizures and ventricular fibrillation in a 13-year-old girl undergoing wound debridement.
Topics: Acute Disease; Adolescent; Anesthetics, Local; Anticonvulsants; Bupivacaine; Debridement; Diazepam; | 1998 |
Buccal route for benzodiazepines in treatment of seizures?
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa | 1999 |
Children presenting with convulsions (including status epilepticus) to a paediatric accident and emergency department: an audit of a treatment protocol.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 1999 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Eth | 1999 |
Role of metabotropic glutamate receptors in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Drug Interactions; Injections, Intraventricu | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protec | 1997 |
Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support.
Topics: Animals; Anticonvulsants; Antidotes; Atropine; Brain; Cerebellum; Cerebral Cortex; Chemical Warfare | 1999 |
Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Synergism; Enzyme Inhibitors; Male; | 1999 |
Independent and combined effects of L-arginine and diazepam on ammonium chloride-induced convulsions in rats.
Topics: Ammonia; Ammonium Chloride; Analysis of Variance; Animals; Anticonvulsants; Arginine; Diazepam; Drug | 1999 |
Respiratory depression in children receiving diazepam for acute seizures: a prospective study.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration S | 1999 |
Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Diazepam; Dopamine; Electroencephalography; Extracellu | 1999 |
Genetic determinants of severity of acute withdrawal from diazepam in mice: commonality with ethanol and pentobarbital.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Diazepam; Ethanol; Hypnotics and S | 1999 |
Pharmacological studies on synthetic flavonoids: comparison with diazepam.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Diazepam; Discrimination Learning; Escape Reaction | 1999 |
Soman-induced hypertension in conscious rats is mediated by prolonged central muscarinic stimulation.
Topics: Animals; Anticonvulsants; Atropine; Atropine Derivatives; Blood Pressure; Brain; Cholinesterase Inhi | 1999 |
Distinct features of seizures induced by cocaine and amphetamine analogs.
Topics: Animals; Central Nervous System Agents; Central Nervous System Stimulants; Diazepam; Dose-Response R | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; | 1999 |
Prehospital management of the seizure patient.
Topics: Adolescent; Adult; Airway Obstruction; Anticonvulsants; Child; Diazepam; Emergency Medical Technicia | 1999 |
Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995).
Topics: Animals; Anticonvulsants; Bromides; Cerebrospinal Fluid; Diazepam; Dog Diseases; Dogs; Female; Male; | 1999 |
Postoperative pseudostatus: not everything that shakes is epilepsy.
Topics: Adult; Anesthesia, General; Anticonvulsants; Contraindications; Diagnosis, Differential; Diazepam; F | 2000 |
Respiratory failure attributable to moxidectin intoxication in a dog.
Topics: Adipose Tissue; Animals; Anthelmintics; Anti-Bacterial Agents; Blood Chemical Analysis; Blood Gas An | 1999 |
Effects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Diazepam; Electric Stimulation; gamma-Aminobutyric | 1999 |
Suspected tolazoline toxicosis in a llama.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Camelids, New Wor | 2000 |
6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity.
Topics: Animals; Anticonvulsants; Diazepam; Flavonoids; Flunitrazepam; GABA Modulators; GABA-A Receptor Anta | 2000 |
Call for diazepam replacement.
Topics: Anticonvulsants; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; Military P | 2000 |
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Bridged Bicyclo Compounds; Convulsants; D | 2000 |
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 2000 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurolo | 2000 |
Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats.
Topics: Ammonia; Animals; Anticonvulsants; Arginine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Diazepa | 1999 |
Call for diazepam replacement.
Topics: Anticonvulsants; Antidotes; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; | 2000 |
Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA(A)-system.
Topics: Animals; Anticonvulsants; Barbiturates; Brazil; Diazepam; Flumazenil; GABA Modulators; Hexanes; Hypn | 2000 |
Induction of pituitary adenylate cyclase-activating polypeptide mRNA in the medial parvocellular part of the paraventricular nucleus of rats following kainic-acid-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, | 2000 |
'Respiratory depression in children receiving diazepam for acute seizures: a prospective study'.
Topics: Administration, Rectal; Canada; Child, Preschool; Diazepam; Drug Administration Schedule; Humans; Pr | 2000 |
The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; | 2000 |
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Conflic | 2000 |
The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine.
Topics: Acetates; Amines; Animals; Anticonvulsants; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; C | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Diazepam replacement.
Topics: Anticonvulsants; Chemical Warfare Agents; Diazepam; Humans; Lorazepam; Military Medicine; Seizures; | 2000 |
Phenobarbital for children with cerebral malaria.
Topics: Anticonvulsants; Chemoprevention; Child; Diazepam; Drug Interactions; Humans; Logistic Models; Malar | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Chloroquine poisoning: report of two cases.
Topics: Adult; Anticonvulsants; Antidotes; Antimalarials; Charcoal; Chloroquine; Coma; Diazepam; Drug Overdo | 2000 |
Acute upregulation of blood-brain barrier glucose transporter activity in seizures.
Topics: 1-Butanol; Acute Disease; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Carbon Radioisotopes | 2000 |
Electroshocks delay seizures and subsequent epileptogenesis but do not prevent neuronal damage in the lithium-pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Down-Regulation; Electrophysiology; Electroshock; Immunoh | 2000 |
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Flumazenil; GABA Modulators; Glutamic Acid; Male; P | 2000 |
Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Cocaine; Convulsants; Diazepam; Dopamine Upt | 2000 |
Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Female; Injection | 2000 |
Use of rectal diazepam in the community.
Topics: Administration, Rectal; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergencies; Humans; Res | 2000 |
Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity.
Topics: Animals; Anticonvulsants; Cardiovascular Agents; Cocaine; Diazepam; Enalapril; Ethanol; Male; Mice; | 2000 |
Neuropharmacological actions of some binuclear lanthanide(III) complexes.
Topics: Animals; Atropine; Convulsants; Defecation; Diazepam; Lethal Dose 50; Metals, Rare Earth; Mice; Mode | 2001 |
The role of nitrergic system in lidocaine-induced convulsion in the mouse.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Arginine; Diazepam; Enzyme Inhibitors; Lidocaine; Male | 2001 |
Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Azabicyclo Compounds; Diazepam; | 2001 |
Safety of Diastat when given at larger-than-recommended doses for acute repetitive seizures.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam; | 2001 |
Caspase-2 activation is redundant during seizure-induced neuronal death.
Topics: Amygdala; Animals; Apoptosis; Brain; Caspase 2; Caspase Inhibitors; Caspases; Cell Nucleus; Cytoplas | 2001 |
AIT-082 is neuroprotective against kainate-induced neuronal injury in rats.
Topics: Aminobenzoates; Analysis of Variance; Animals; Cell Survival; Dentate Gyrus; Diazepam; Electroenceph | 2001 |
Differences between the tolerance characteristics of two anticonvulsant benzodiazepines in the amygdaloid-kindled rat.
Topics: Amygdala; Animals; Anticonvulsants; Clorazepate Dipotassium; Diazepam; Drug Tolerance; Electric Stim | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Mod | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; | 2001 |
Seizures with intravenous codeine phosphate.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Anticonvulsants; Child; Codeine; Diazepam; Humans; Injectio | 2001 |
Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde.
Topics: Anticonvulsants; Cohort Studies; Diazepam; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infusio | 2001 |
Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions.
Topics: Administration, Rectal; Anticonvulsants; Area Under Curve; Child, Preschool; Diazepam; Female; Human | 2002 |
Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Aspirin; Diazepam; Male; Mice; Pentylenetetrazole; Prostaglandins; Seizure | 2001 |
Intracavernous application of diazepam: an alternative route of the seizure treatment--an experimental study in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Humans; Male; Penis; Rabbits; Seizures | 2002 |
Combination anticonvulsant treatment of soman-induced seizures.
Topics: Animals; Anticonvulsants; Chemical Warfare Agents; Diazepam; Drug Interactions; Drug Therapy, Combin | 2001 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C | 1976 |
[Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Cats; Cerebral Cortex; Clonazepam; Diazepam; E | 1977 |
Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Corpus Callosum; Diazepam; Electric Stimulation | 1975 |
[Action of ketamine of paroxysmal discharges provoked by air emboli in the baboon Papio papio].
Topics: Animals; Blood Pressure; Diazepam; Electroencephalography; Embolism, Air; Haplorhini; Intracranial E | 1976 |
The effect of procaine hydrochloride and diazepam, separately or in combination, on cortico-generalized kindled seizures.
Topics: Animals; Cerebral Cortex; Diazepam; Electrophysiology; Kindling, Neurologic; Male; Procaine; Rats; S | 1979 |
Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Cerebellum; Diazepam; gamma-Aminobutyric | 1978 |
Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital.
Topics: Animals; Diazepam; Female; Haplorhini; Learning; Male; Motor Activity; Papio; Phenobarbital; Seizure | 1978 |
Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Diazepam; Electroencephalography; Ethosuximi | 1978 |
[Epileptogenic action of intra-amygdaloid injection of kainic acid].
Topics: Amygdala; Animals; Diazepam; Disease Models, Animal; Hippocampus; Injections; Kainic Acid; Male; Pyr | 1978 |
[Provocation of tonic seizures during intravenous faustan administration].
Topics: Adolescent; Diazepam; Electroencephalography; Epilepsy, Absence; Female; Humans; Seizures | 1978 |
[Heart noradrenaline and dopamine during acute poisoning of rat by an anticholinesterasic pesticide: parathion].
Topics: Acetylcholine; Animals; Atropine; Carbamates; Diazepam; Dopamine; Female; Heart; Heart Rate; Myocard | 1975 |
Effects of gaba, gabob and some anticonvulsant drugs on dibutyryl cyclic AMP evoked seizures.
Topics: Aminobutyrates; Animals; Anticonvulsants; Bucladesine; Chickens; Diazepam; Electroencephalography; F | 1977 |
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In | 1977 |
Bicyclic phosphorus esters increase the cyclic GMP level in rat cerebellum.
Topics: Animals; Atropine; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Diazepam; Dose-Respon | 1977 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
[Na, K-ATPase activity of the meninges in electroshock and the action of the anticonvulsant agent, diazepam].
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Electroshock; Enzyme Acti | 1979 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; | 1979 |
[Effect of diazepam on the Na, K-ATPase state in a penicillin--induced hyperactivity focus in the cerebral cortex].
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Enzyme Activation; Male; Penicillins; Ra | 1979 |
Theophylline-induced seizures in adults. Correlation with serum concentrations.
Topics: Adult; Aged; Creatinine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Co | 1975 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Toxicological and pharmacological investigations of pinazepam (7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one): a new psychotherapeutic agent.
Topics: Abnormalities, Drug-Induced; Aggression; Analgesia; Animals; Anti-Anxiety Agents; Blood Pressure; Ca | 1975 |
Trials of the elimination of the central effects of Ronpacon Cerebral 280 after its administration into the cerebral lateral ventricle in rats.
Topics: Animals; Cerebral Ventriculography; Contrast Media; Diazepam; Drug Antagonism; Female; Glutethimide; | 1978 |
Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
Topics: Administration, Oral; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injectio | 1978 |
Anesthetic management of conray toxicity.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Cerebrospinal Fluid Shunts; Child; Diazepam; Female | 1978 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps | 1977 |
A comparison of the effects of chronically administered diazepam and phenobarbital and learning in the Papio papio model of epilepsy.
Topics: Animals; Diazepam; Disease Models, Animal; Haplorhini; Learning; Papio; Phenobarbital; Seizures; Sti | 1977 |
Further studies on the site of action of diazepam: anticonvulsant effect in the rabbit.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroenceph | 1979 |
[Effect of diazepam on the epileptic activity of rats with experimental photogenic epilepsy].
Topics: Animals; Diazepam; Electrophysiology; Evoked Potentials; Geniculate Bodies; Male; Photic Stimulation | 1979 |
Evidence suggesting secondary epileptogenic lesion after kainic acid: pre treatment with diazepam reduces distant but not local brain damage.
Topics: Amygdala; Animals; Diazepam; Hippocampus; Kainic Acid; Nerve Degeneration; Neural Pathways; Premedic | 1979 |
Cat optic nerve imaging with metrizamide.
Topics: Animals; Cats; Diazepam; Metrizamide; Optic Nerve; Optic Nerve Injuries; Orbit; Radiography; Seizure | 1979 |
Management of the convulsing child.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Infant, Newborn, Disea | 1979 |
Prophylactic diazepam in febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Seizures; Seizures, Febrile | 1979 |
Convulsive arterial plasma levels of bupivacaine and the response to diazepam therapy.
Topics: Adult; Aged; Bupivacaine; Diazepam; Female; Humans; Seizures | 1979 |
[Intermittent prophylaxis of febrile convulsions with diazepam].
Topics: Child, Preschool; Diazepam; Drug Evaluation; Female; Follow-Up Studies; Humans; Infant; Male; Recurr | 1979 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
[Problem of focal pathology in "genuine" epilepsy].
Topics: Animals; Chronic Disease; Cortical Synchronization; Diazepam; Electroencephalography; Evoked Potenti | 1979 |
The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs.
Topics: Animals; Chlorpromazine; Diazepam; Drug Evaluation, Preclinical; Halothane; Male; Mice; Phenobarbita | 1979 |
Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children.
Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Fever | 1979 |
Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.
Topics: Acute Disease; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Prospective Studies; Rectum; Se | 1979 |
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Pic | 1979 |
[Effects of benzodiazepines on amygdaloid kindled convulsion-differences of efficacy among diazepam, bromazepam and lorazepam-(author's transl)].
Topics: Amygdala; Animals; Benzodiazepinones; Bromazepam; Diazepam; Electric Stimulation; Lorazepam; Male; R | 1979 |
Comparative study of the antagonism of bemegride and picrotoxin on behavioural depressant effects of diazepam in rats and mice.
Topics: Amnesia; Animals; Behavior, Animal; Bemegride; Diazepam; Humans; Male; Mice; Motor Activity; Motor S | 1978 |
Withdrawal convulsions or stress convulsions.
Topics: Adult; Diazepam; Humans; Male; Seizures; Stress, Physiological; Substance Withdrawal Syndrome | 1977 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
Current views on the management of eclampsia.
Topics: Abruptio Placentae; Acid-Base Equilibrium; Acute Kidney Injury; Diazepam; Eclampsia; Female; Fever; | 1977 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1977 |
Diazepam in combination with antiepileptic drugs--an experimental study.
Topics: Animals; Anticonvulsants; Diazepam; Drug Therapy, Combination; Rats; Seizures | 1977 |
Management of alcohol withdrawal syndromes.
Topics: Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Diazepam; Dose-Response Relationship, Dru | 1978 |
Management of neonatal drug withdrawal.
Topics: Diazepam; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Seizures | 1978 |
Management of narcotic withdrawal in neonates.
Topics: Diazepam; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Newborn, Diseases; Narcotics; | 1978 |
The influence of biperiden, benztropine, physostigmine and diazepam on the convulsive effects of Cicuta douglasii.
Topics: Animals; Benztropine; Biperiden; Cholinesterase Inhibitors; Diazepam; Dose-Response Relationship, Dr | 1978 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Amino | 1978 |
[Febrile convulsions in children].
Topics: Child, Preschool; Diazepam; Humans; Infant; Paraldehyde; Seizures; Seizures, Febrile | 1978 |
[Physiopathological concepts on eclampsia (author's transl)].
Topics: Body Weight; Cesarean Section; Diazepam; Diet, Sodium-Restricted; Female; Furosemide; Humans; Hypert | 1978 |
Rapid changes in brain benzodiazepine receptors after experimental seizures.
Topics: Animals; Binding Sites; Brain; Cerebral Cortex; Diazepam; Electroshock; Hypoxia; Kinetics; Male; Pen | 1978 |
Febrile convulsions--what do parents do?
Topics: Attitude; Child; Child, Preschool; Diazepam; Female; Home Nursing; Hospitalization; Humans; Infant; | 1978 |
Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs.
Topics: Animals; Antidotes; Diazepam; Dogs; Drug Therapy, Combination; Isoniazid; Male; Pyridoxine; Rats; Se | 1978 |
Preventing febrile convulsions.
Topics: Child, Preschool; Diazepam; Humans; Infant; Phenobarbital; Seizures; Seizures, Febrile | 1978 |
Changes in the convulsion threshold and in the level of brain biogenic amines in rats chronically treated with phenobarbital or diazepam.
Topics: Animals; Biogenic Amines; Brain Chemistry; Diazepam; Dopamine; Drug Synergism; Male; Norepinephrine; | 1978 |
The anticonvulsant activity of ropizine in the rat.
Topics: Action Potentials; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Electroshock; Hippocampus; M | 1979 |
Adverse reactions to local anaesthetics and vasoconstrictor drugs.
Topics: Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Arteriosclerosis; Blood Pressure; Coronary Dise | 1975 |
Problems of childhood. Febrile fits.
Topics: Age Factors; Child, Preschool; Diazepam; Epilepsy, Tonic-Clonic; Female; Fever; Humans; Infant; Male | 1976 |
Diazepam in the prophylaxis of lignocaine seizures.
Topics: Acid-Base Equilibrium; Animals; Behavior, Animal; Carbon Dioxide; Diazepam; Haplorhini; Lidocaine; M | 1976 |
The influence of intravenous anaesthetics on enflurane-induced central nervous system seizure activity.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Brain; Cats; Diazepam; Drug S | 1977 |
Seizures and related epileptiform activity in hippocampus transplanted to the anterior chamber of the eye I. Characterization of seizures, interictal spikes, and synchronous activity.
Topics: Animals; Anterior Chamber; Cerebellum; Cobalt; Diazepam; Electric Stimulation; Evoked Potentials; Fe | 1977 |
Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinol; Carbamazepine; Diazepam; Dose-Response Relationsh | 1977 |
[Acute treatment with diazepam].
Topics: Child; Child, Preschool; Diazepam; Humans; Seizures; Seizures, Febrile | 1977 |
Pentobarbital, diazepam and bemegride: their effects on open-field behavior in the gerbil (Meriones unguiculatus).
Topics: Animals; Behavior, Animal; Bemegride; Body Temperature; Diazepam; Drug Interactions; Female; Gerbill | 1977 |
Effect of diazepam on pyramidal tract and electromyographic multiple unit activities of cats with chronic epileptogenic foci.
Topics: Action Potentials; Animals; Arousal; Cats; Diazepam; Electromyography; Motor Activity; Pyramidal Tra | 1977 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
Potentiation of Amipaque epileptogenic activity by neuroleptics.
Topics: Animals; Chlorpromazine; Contrast Media; Diazepam; Drug Synergism; Iodobenzoates; Metrizamide; Pheno | 1977 |
The behavioral and electrical interactions of electrically induced hippocampal seizures and four anticonvulsants.
Topics: Animals; Anticonvulsants; Conditioning, Operant; Diazepam; Electric Stimulation; Electroencephalogra | 1977 |
Neonatal seizures associated with narcotic withdrawal.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Pregnanc | 1977 |
Effects of acute cerebellectomy on maximal electroshock seizures and anticonvulsant efficacy of diazepam in the rat.
Topics: Animals; Cerebellum; Diazepam; Electroshock; Male; Pentylenetetrazole; Rats; Seizures | 1976 |
[Micromethod of diazepam determination in the blood by gas-liquid chromatography. Application in neonatal pharmacology].
Topics: Chromatography, Gas; Diazepam; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; | 1976 |
Intracisternal dimer X: toxicity and prophylaxis.
Topics: Animals; Cerebral Cortex; Dexamethasone; Diazepam; Injections, Spinal; Iothalamate Meglumine; Iothal | 1976 |
[Influence of diazepam and phenytoin on penicillin-induced cerebral convulsions (author's transl)].
Topics: Animals; Diazepam; Electroencephalography; Penicillin G; Phenytoin; Rabbits; Seizures | 1976 |
Etiology of convulsions in neonatal and infantile period.
Topics: Age Factors; Birth Injuries; Brain; Diazepam; Electroencephalography; Female; Humans; Infant; Infant | 1976 |
[Side reaction after lumbar myelography with dimer-x (author's transl)].
Topics: Adolescent; Adult; Diazepam; Epilepsy; Female; Humans; Iothalamic Acid; Lumbar Vertebrae; Male; Midd | 1976 |
[The etiology and therapy of febrile convulsive attacks in the infant age].
Topics: Age Factors; Diazepam; Humans; Infant; Infant, Newborn; Seizures; Seizures, Febrile | 1976 |
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold.
Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizu | 1976 |
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline.
Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pim | 1976 |
[Heroin withdrawal syndrome in newborns (author's transl].
Topics: Chloral Hydrate; Diazepam; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant | 1976 |
[Depressive effects of benzodiazepines on penicillin-induced epileptic discharges].
Topics: Animals; Benzodiazepines; Cats; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Electroencep | 1976 |
Some important pitfalls in the diagnosis and treatment of bacterial meningitis in children.
Topics: Anti-Bacterial Agents; Bacterial Infections; Barbiturates; Cerebral Ventriculography; Cerebrospinal | 1975 |
Post-operative convulsions due to penicillin applied to the spinal theca.
Topics: Adult; Cyanosis; Diazepam; Female; Humans; Intermittent Positive-Pressure Breathing; Middle Aged; Ox | 1975 |
The effect of cold and diazepam on the toxicity of fenfluramine in mice.
Topics: Animals; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Fenfluramine; Male; Mice; Mod | 1975 |
Etidocaine, bupivacaine, and lidocaine seizure thresholds in monkeys.
Topics: Acetanilides; Acid-Base Equilibrium; Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Anima | 1975 |
[The mechanism of the anticonvulsive action of diazepam].
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Paper; Diazepam; E | 1975 |
Letter: The ketogenic diet, West and Lennox syndromes.
Topics: Child; Child, Preschool; Clonazepam; Diazepam; Humans; Infant; Intellectual Disability; Myoclonus; N | 1975 |
Central nervous system effects of bupivacaine.
Topics: Amygdala; Anesthesia, General; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Ca | 1975 |
Intravenous therapy and EEG monitoring in prolonged seizures.
Topics: Adolescent; Child; Child, Preschool; Diazepam; Electroencephalography; Humans; In Vitro Techniques; | 1975 |
Orphenadrine poisoning in childhood.
Topics: Child, Preschool; Diazepam; Female; Humans; Infant; Orphenadrine; Paraldehyde; Poisoning; Seizures | 1975 |
Plasma levels of diazepam after parenteral and rectal administration in children.
Topics: Child; Child, Preschool; Chromatography, Gas; Diazepam; Enema; Female; Humans; Infant; Injections, I | 1975 |
Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
Topics: Administration, Oral; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; I | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
The comatose patient.
Topics: Coma; Dexamethasone; Diazepam; Emergencies; Fever; Glucose; Humans; Hypothermia; Intracranial Pressu | 1975 |
The use of diazepam and methocarbamol in the treatment of toxaphene poisoning in a Bangal tiger.
Topics: Animals; Carnivora; Diazepam; Female; Insecticides; Meat; Methocarbamol; Seizures; Toxaphene | 1975 |
Cyclobenzaprine: novel centrally acting skeletal muscle relaxant.
Topics: Amitriptyline; Animals; Anticonvulsants; Ataxia; Cats; Chlorpromazine; Decerebrate State; Diazepam; | 1975 |
[Febrile convulsions in childhood. Clinico-statistical study].
Topics: Age Factors; Analgesics; Anti-Bacterial Agents; Barbiturates; Child; Child, Preschool; Diazepam; Fev | 1975 |
Letter: Physostigmine as an antidote: use with caution.
Topics: Antidepressive Agents, Tricyclic; Antidotes; Diazepam; Humans; Physostigmine; Seizures | 1975 |
Diazepam prophylaxis for lignocaine induced convulsions.
Topics: Animals; Diazepam; Gait; Injections, Intraperitoneal; Lidocaine; Phenobarbital; Rats; Seizures; Wake | 1975 |
[Treatment and prevention of convulsion syndrome in infancy and childhood].
Topics: Adolescent; Child; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Seizures; Syndrome | 1975 |
[Effect of diazepam and phenytoin on penicillin-induced convulsions].
Topics: Animals; Diazepam; Penicillin G; Phenytoin; Rabbits; Seizures | 1975 |
Accidental subarachnoid injection of gallamine. A case report.
Topics: Anesthesia, Spinal; Blood Pressure; Chromatography, Thin Layer; Dexamethasone; Diazepam; Gallamine T | 1975 |
Suicidal ingestion of isoniazid: an uncommon cause of metabolic acidosis and seizures.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Diazepam; Diuresis; Female; Humans; Infusions, Parenteral | 1976 |
Benzodiazepines and central glycine receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Chlordiazepoxide; Diazepam; Glycine; Mice; Receptors, | 1976 |
Simple febrile convulsions.
Topics: Cerebrospinal Fluid; Child, Preschool; Diazepam; Emergency Service, Hospital; Fever; Humans; Infant; | 1976 |
[2 cases of strychnine poisoning].
Topics: Adult; Diazepam; Female; Gastric Lavage; Humans; Male; Pancuronium; Poisoning; Respiration, Artifici | 1976 |
Adverse effects of lumbar myelography with amipaque and dimer-X.
Topics: Adult; Aged; Brain; Diazepam; Drug Evaluation; Electroencephalography; Female; Fever; Headache; Huma | 1976 |
Electroconvulsive stimuli and brain peptides: effect of modification of seizure duration on neuropeptide Y, neurokinin A, substance P and neurotensin.
Topics: Animals; Brain; Diazepam; Eicosanoids; Electroshock; Male; Neurokinin A; Neuropeptide Y; Neuropeptid | 1992 |
Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.
Topics: Administration, Oral; Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female | 1992 |
Effects of flumazenil on intravenous lidocaine-induced convulsions and anticonvulsant property of diazepam in rats.
Topics: Animals; Anticonvulsants; Bicarbonates; Blood Pressure; Carbon Dioxide; Convulsants; Diazepam; Dose- | 1992 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inb | 1992 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Pi | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds | 1992 |
Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study.
Topics: 2-Chloroadenosine; Amygdala; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; D | 1992 |
Ro 19-8022, a nonbenzodiazepine partial agonist at benzodiazepine receptors: neuropharmacological profile of a potential anxiolytic.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Conditioning, Operant; Diazepam | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate D | 1992 |
Antagonism of ethanol withdrawal convulsions in Withdrawal Seizure Prone mice by diazepam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Diazepam; Ethanol; Female; Mice; Seizures | 1992 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
[Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].
Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Diazepam; Dizocilpin | 1992 |
Per rectal diazepam therapy in convulsive disorders.
Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infant, Newborn; | 1992 |
[Efficacy of a diazepam solution for rectal administration in the control of febrile convulsions].
Topics: Administration, Rectal; Child; Diazepam; Fever; Humans; Seizures; Solutions | 1992 |
Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol.
Topics: Aggression; Animals; Behavior, Animal; Ceruletide; Dextroamphetamine; Diazepam; Electroshock; Halope | 1992 |
Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroshock; Epilepsy, Tonic-Clonic; Inje | 1992 |
Diazepam use & intubation.
Topics: Age Factors; Child; Diazepam; Humans; Intubation, Intratracheal; Observer Variation; Respiratory Ins | 1992 |
The comparative effects of propofol, thiopental, and diazepam, administered intravenously, on pentylenetetrazol seizure threshold in the rabbit.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Injections, Intravenous; Male; Pentylenetetraz | 1992 |
Behavioral performance, brain histology, and EEG sequela after immediate combined atropine/diazepam treatment of soman-intoxicated rats.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Brain; Diazepam; Electroencephalography; Ma | 1992 |
Seizure following brief exposure to the insect repellent N,N-diethyl-m-toluamide.
Topics: Administration, Topical; Charcoal; Child, Preschool; Decontamination; DEET; Diazepam; Drug Combinati | 1992 |
Tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Diazepam; Drug Tolerance; Electrodes, Impl | 1992 |
Strychnine poisoning in an adolescent.
Topics: Adolescent; Anti-Bacterial Agents; Diazepam; Drug Contamination; Female; Humans; Poisoning; Seizures | 1992 |
In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pentobarbital; | 1992 |
Buflomedil intoxication: the little-known risk.
Topics: Adult; Diazepam; Female; Humans; Poisoning; Pyrrolidines; Seizures; Vasodilator Agents | 1992 |
Kynurenine and probenecid inhibit pentylenetetrazol- and NMDLA-induced seizures and increase kynurenic acid concentrations in the brain.
Topics: Analysis of Variance; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; Dose-Response Rela | 1992 |
Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats.
Topics: Aminophylline; Anesthesia; Animals; Anticonvulsants; Carbamazepine; Consciousness; Diazepam; Electro | 1992 |
Repeated anticonvulsant testing: contingent tolerance to diazepam and clobazam in kindled rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa | 1992 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Femal | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cort | 1991 |
Interaction of felbamate and diazepam against maximal electroshock seizures and chemoconvulsants in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Diazepam; Drug Interactions; Electroshock; Felbamate; GABA-A | 1991 |
GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Topics: Animals; Baclofen; Diazepam; Digoxin; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Injectio | 1991 |
Pharmacologic profile of a new anxiolytic, DN-2327: effect of Ro15-1788 and interaction with diazepam in rodents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diaz | 1991 |
Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Atropine; Brain Chemistry; | 1991 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; | 1990 |
c-fos and ornithine decarboxylase gene expression in brain as early markers of neurotoxicity.
Topics: Animals; Cerebral Cortex; Diazepam; Gene Expression; Hexachlorocyclohexane; Male; Nervous System; Or | 1991 |
Effects of immobilization stress on hippocampal interictal discharges in hippocampal kindled rats.
Topics: Animals; Arousal; Brain Mapping; Diazepam; Electroencephalography; Hippocampus; Kindling, Neurologic | 1991 |
Spinal cord seizures: a possible cause of isolated myoclonic activity in traumatic spinal cord injury: case report.
Topics: Blood Pressure; Diazepam; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Post-Traumatic; H | 1991 |
Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys.
Topics: Animals; Anticonvulsants; Blood Proteins; Diazepam; Hematocrit; Injections, Intramuscular; Macaca mu | 1991 |
Diazepam alters brain-stimulation reward thresholds in seizure-prone sites.
Topics: Animals; Brain Mapping; Diazepam; Hypothalamic Area, Lateral; Male; Medial Forebrain Bundle; Motivat | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; g | 1991 |
Modulation of monomethylhydrazine-induced seizures by ivermectin.
Topics: Animals; Diazepam; Injections, Intraperitoneal; Ivermectin; Male; Mice; Mice, Inbred ICR; Monomethyl | 1991 |
Cholinergic actions of diazepam and atropine sulfate in soman poisoning.
Topics: Acetylcholine; Animals; Atropine; Brain; Cholinesterase Inhibitors; Cholinesterases; Diazepam; Eryth | 1991 |
The effect of diazepam enema on the rectal mucosa of rats.
Topics: Administration, Rectal; Animals; Diazepam; Drug Evaluation, Preclinical; Emergencies; Enema; Mucous | 1991 |
Diazepam and intubation in emergency treatment of seizures in children.
Topics: Adolescent; Body Weight; Case-Control Studies; Child; Child, Preschool; Diazepam; Drug Therapy, Comb | 1991 |
Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Cerebral Ventricles; Diazepam | 1991 |
Diazepam-atenolol combination antagonizes aminophylline-induced convulsions and lethality in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Atenolol; Diazepam; Dose-Response Relationship, Drug; Male; | 1991 |
[Emergency management of convulsions and prevention of status epilepticus with rectal diazepam administered by parents].
Topics: Administration, Rectal; Child, Preschool; Diazepam; Emergencies; Female; Home Nursing; Humans; Infan | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relations | 1991 |
The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; | 1990 |
Preclinical anxiolytic profiles of 7189 and 8319, novel non-competitive NMDA antagonists.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Binding, Competi | 1990 |
Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Diazepam; Insulin; Male; Necrosis; Nervous System; R | 1991 |
Effect of an anticholinesterase compound on the ultrastructure and function of the rat blood-brain barrier: a review and experiment.
Topics: Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Diazepam; Hexamethonium Compounds; H | 1991 |
Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Body Temperature Regulation; | 1990 |
The prevention of convulsions during benzodiazepine withdrawals.
Topics: Adolescent; Adult; Benzodiazepines; Diazepam; Female; Humans; Male; Seizures; Substance Withdrawal S | 1990 |
Anticonvulsive properties of F1933 (dulozafone) on kindled seizures in the rat.
Topics: Acetanilides; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Flumazenil; Kindli | 1990 |
Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors.
Topics: Animals; Autoradiography; Diazepam; Flunitrazepam; Kainic Acid; Quinuclidinyl Benzilate; Rats; Rats, | 1990 |
Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Diazepam; Ergotamines; Female; gamma-Aminobutyric Ac | 1990 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
[Risks of diazepam in newborn infants].
Topics: Asphyxia Neonatorum; Diazepam; Humans; Infant, Newborn; Male; Medication Errors; Seizures | 1990 |
Antagonism of cocaine, amphetamine, and methamphetamine toxicity.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Diazepam; Dimethyl Sulfoxide; Dizocilpine Maleate; | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neur | 1990 |
Diazepam sensitive mice: differential sensitivity to the depressant and anticonvulsant effects of diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Hypnotics and Sedatives; Mice; Mice, Inbred Str | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Protection against d-amphetamine toxicity.
Topics: Animals; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Haloperidol; Injections, Int | 1990 |
Tolerance to diazepam and methyl-beta-carboline-3-carboxylate measured in substantia nigra of benzodiazepine tolerant rats.
Topics: Animals; Benzodiazepines; Carbolines; Chloral Hydrate; Diazepam; Drug Tolerance; Electrophysiology; | 1990 |
Modification of amygdaloid kindling by diazepam in juvenile rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation | 1990 |
Effects of diltiazem on hyperthermia induced seizures in the rat pup.
Topics: Animals; Behavior, Animal; Body Temperature; Diazepam; Diltiazem; Fever; Phenytoin; Rats; Rats, Inbr | 1990 |
Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, High Pressure Liquid; Diaz | 1990 |
Risks associated with giving benzodiazepines to patients with acute neurological injuries.
Topics: Adult; Aged; Child; Craniocerebral Trauma; Diazepam; Emergency Medical Services; Female; Humans; Mal | 1990 |
Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels.
Topics: Diazepam; Humans; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Lidocaine; Seizures | 1990 |
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
Topics: Anesthetics; Animals; Atropine; Behavior, Animal; Bicuculline; Diazepam; Electroencephalography; Eth | 1988 |
Rectal diazepam solution in the treatment of convulsions in the children's emergency room.
Topics: Administration, Rectal; Allied Health Personnel; Child; Child, Preschool; Diazepam; Emergency Servic | 1988 |
Estrogen modulation of the gamma-aminobutyric acid receptor complex in the central nervous system of rat.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Dose-R | 1988 |
Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice.
Topics: Animals; Diazepam; Ethanol; Flumazenil; Mice; Mice, Inbred Strains; Seizures; Substance Withdrawal S | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain C | 1989 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol | 1989 |
Effects of diazepam on soman-induced brain neuronal RNA depletion and lethality in rats.
Topics: Acetylcholinesterase; Animals; Brain; Cerebral Cortex; Cholinesterase Inhibitors; Cholinesterases; C | 1985 |
Diazepam in the prevention of seizures and death in cocaine-intoxicated rats.
Topics: Animals; Cocaine; Diazepam; Electroencephalography; Male; Rats; Rats, Inbred Strains; Seizures | 1989 |
Unexpected cocaine intoxication presenting as seizures in children.
Topics: Child, Preschool; Cocaine; Diazepam; Emergencies; Female; Gastric Lavage; Humans; Infant; Male; Phen | 1989 |
Near-fatal hydrogen peroxide ingestion.
Topics: Administration, Oral; Adult; Diazepam; Female; Gastric Lavage; Humans; Hydrogen Peroxide; Respirator | 1989 |
Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Drug Tolerance; Imidazoles; Injections, Intra | 1989 |
Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Clonazepam; Diazepam; Drug Therapy, Combination; Isoniazid; | 1989 |
Emergency management of seizures: an overview.
Topics: Diazepam; Emergencies; Humans; Lidocaine; Lorazepam; Phenytoin; Prodrugs; Seizures; Status Epileptic | 1989 |
3-(Methoxycarbonyl)-amino-beta-carboline reduces both the sedative and anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Bicuculline; Carbolines; Diazepam; Hypnotics and Sedatives; Male; Mice; Se | 1989 |
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random A | 1989 |
Effects of bicuculline-induced seizures on benzodiazepine and adenosine receptors in developing rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Female; Male; Rats; Receptors, GABA-A; Receptors, Purinergic; | 1987 |
[Effects of anticonvulsants on the cyclic nucleotide content of the plasma and cerebellum of convulsive rats].
Topics: Animals; Anticonvulsants; Cerebellum; Clonazepam; Cyclic AMP; Cyclic GMP; Diazepam; Male; Organophos | 1987 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Decreased sensitivity to diazepam induced by chronic administration of FG 7142.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Brain Chemistry; Carbolines; Convulsants; | 1988 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lys | 1988 |
Co-existence of kindling induced by the beta-carboline, FG 7142, and tolerance to diazepam following chronic treatment in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Carbolines; Diazepam; Drug Tolerance; Female; Kindlin | 1988 |
Soman-induced convulsions affect the inositol lipid signaling system: potentiation by lithium; attenuation by atropine and diazepam.
Topics: Animals; Atropine; Brain; Diazepam; Drug Interactions; Lithium; Male; Phosphatidylinositols; Rats; R | 1988 |
Delta-guanidinovaleric acid as an endogenous and specific GABA-receptor antagonist: electroencephalographic study.
Topics: Animals; Arginine; Cerebral Cortex; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Male; | 1987 |
Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain.
Topics: Acoustic Stimulation; Animals; Azides; Benzodiazepines; Body Temperature; Brain Chemistry; Diazepam; | 1988 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole | 1988 |
Treatment of episodic behavioral disorders with rapidly absorbed benzodiazepines.
Topics: Administration, Oral; Adult; Aggression; Anger; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazep | 1985 |
Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines.
Topics: Aggression; Animals; Anti-Anxiety Agents; Benzodiazepines; Caffeine; Dextroamphetamine; Diazepam; El | 1985 |
[Central convulsive action of l-securinine].
Topics: Alkaloids; Animals; Azepines; Central Nervous System Stimulants; Diazepam; Drug Synergism; gamma-Ami | 1986 |
Interactions of aminophylline and three benzodiazepine compounds with amygdala-kindled seizures in rats.
Topics: Aminophylline; Amygdala; Animals; Anti-Anxiety Agents; Diazepam; Drug Interactions; Flumazenil; Kind | 1987 |
Seizures following triazolam withdrawal despite benzodiazepine treatment.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Recep | 1987 |
Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Feeding Behavior; Flumaz | 1988 |
Effects of lisuride and quinpirole on convulsions induced by hyperbaric oxygen in the mouse.
Topics: Animals; Body Temperature; Diazepam; Dopamine Agents; Drug Interactions; Ergolines; Haloperidol; Hyp | 1988 |
Analysis of the mechanism of psychotropic action of a 3-hydroxypyridine derivative.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Binding, Competitive; Conflict, P | 1988 |
Managing cocaine crisis.
Topics: Arrhythmias, Cardiac; Cocaine; Diazepam; Humans; Hypertension; Labetalol; Seizures; Substance-Relate | 1989 |
The effect of diazepam on neonatal seizure: in vivo 31P and 1H NMR study.
Topics: Acetates; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Brain; Diazepam; Dogs; Electroen | 1989 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pen | 1985 |
Comparative effects of diazepam and midazolam on paraoxon toxicity in rats.
Topics: Animals; Atropine; Benzodiazepines; Diazepam; Drug Interactions; Injections, Subcutaneous; Lethal Do | 1985 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; | 1986 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
[Convulsive attacks and the dentist].
Topics: Adolescent; Child; Child, Preschool; Dental Care for Disabled; Diazepam; Emergencies; Epilepsy; Ging | 1988 |
Amygdala kindled seizure stage is related to altered benzodiazepine binding site density.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Hippocampus; Kindling, Neurologic; Kinetics; Male | 1985 |
Supraspinal convulsions induced by inverse benzodiazepine agonists in rabbits.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Electroencephalography; Flumazenil; Male; Pyrazole | 1985 |
Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences.
Topics: Animals; Bicuculline; Brain; Delayed-Action Preparations; Diazepam; gamma-Aminobutyric Acid; Male; R | 1985 |
Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures.
Topics: Animals; Brain Chemistry; Clonidine; Diazepam; Haloperidol; Kainic Acid; Male; Metergoline; Prazosin | 1985 |
CGS 9896: agonist-antagonist benzodiazepine receptor activity revealed by anxiolytic, anticonvulsant and muscle relaxation assessment in rodents.
Topics: Acoustic Stimulation; Aggression; Agonistic Behavior; Animals; Conditioning, Operant; Diazepam; Dose | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ketamine; Male; Penicillins; Pentobarbit | 1985 |
Convulsant component of a depressant benzodiazepine.
Topics: Animals; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Pentylenet | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picroto | 1986 |
Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions | 1986 |
The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Female; Mice; Mice, Inbred C3H; | 1986 |
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Rel | 1986 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; | 1986 |
Apparent pA2 estimation of benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; Drug Interactions; Female; Flumazenil; Male; Pentylenetetrazole; Pyrazoles; Rats; | 1986 |
Neurobehavioral, neuroendocrine and neurochemical effects of zinc supplementation in rats.
Topics: Adrenocorticotropic Hormone; Animals; Baclofen; Behavior, Animal; beta-Endorphin; Brain; Diazepam; E | 1986 |
Mapping patterns of c-fos expression in the central nervous system after seizure.
Topics: Animals; Brain Chemistry; Diazepam; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expre | 1987 |
Resuscitation in the accident and emergency department.
Topics: Diazepam; Emergency Service, Hospital; Humans; Resuscitation; Seizures | 1986 |
Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Carbamazepine; Diazepam; Female; Glutamates; Mice; Ox | 1986 |
Microgram doses of diazepam do not induce proconvulsant or proconflict effects in rodents.
Topics: Animals; Bicuculline; Conditioning, Operant; Diazepam; Isoniazid; Mice; Pentylenetetrazole; Picrotox | 1987 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Pharmacological studies on anethole trithione.
Topics: Anethole Trithione; Animals; Anisoles; Autonomic Nervous System; Blood Pressure; Body Temperature; C | 1988 |
Effects of prolonged weak anodal direct current on electrocorticogram in awake rabbit.
Topics: Animals; Cerebral Cortex; Diazepam; Electric Stimulation; Electrodes; Electroencephalography; Male; | 1988 |
Alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Psychoses, Alcoh | 1988 |
CL 218-872 pretreatment and intervention block kainate-induced convulsions and neuropathology.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Kainic Acid; Male; Organ Specificity; Pyridazines; Rats; | 1988 |
Triazolam withdrawal.
Topics: Alprazolam; Diazepam; Drug Tolerance; Humans; Seizures; Substance Withdrawal Syndrome; Triazolam | 1988 |
[Neurotoxicity and cardiotoxicity of bupivacaine on the Papio papio baboon].
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Diazepam; Drug Interactions; Hypertension; Papio; Seizur | 1987 |
[Effects of reserpine on the protective function of diazepam against hyperbaric oxygen-induced convulsions].
Topics: Animals; Brain; Diazepam; Dopamine; Female; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; Male; N | 1987 |
Effects of antidotes on soman-induced brain changes.
Topics: Animals; Antidotes; Atropine; Benactyzine; Brain; Diazepam; Glucose; Male; Rats; Rats, Inbred Strain | 1986 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diaz | 1986 |
Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.
Topics: Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Diazepam; Isoflurophate; Male; Midaz | 1987 |
Nonmuscarinic neurotoxicity of oxotremorine.
Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose | 1987 |
Lack of tolerance or withdrawal effects in mice after chronic administration of the non-sedating anxiolytic, CGS 9896.
Topics: Animals; Diazepam; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Motor Activity; Pyrazoles; Refl | 1987 |
Emergency applications of intraosseous infusion.
Topics: Ampicillin; Child, Preschool; Craniocerebral Trauma; Diazepam; Emergencies; Female; Fluid Therapy; H | 1987 |
Therapeutic aspirin overdose in a three-year-old boy.
Topics: Aspirin; Child, Preschool; Diazepam; Fever; Humans; Male; Seizures | 1987 |
The anticonvulsive activity and toxicity of diazepam in three different formulations. An experimental study in mice.
Topics: Animals; Diazepam; Emulsions; Injections, Intravenous; Male; Mice; Pentylenetetrazole; Seizures | 1987 |
[Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam].
Topics: Animals; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Pent | 1987 |
Glycine potentiates diazepam anticonvulsant activity in electroshock seizures of rats: possible sites of interaction in the brainstem.
Topics: Administration, Oral; Animals; Anticonvulsants; Diazepam; Drug Therapy, Combination; Electroshock; G | 1987 |
Effect of a cholecystokinin antagonist on some effects of diazepam.
Topics: Animals; Cholecystokinin; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Mal | 1987 |
Attenuation of cerebral glucose use in kainic acid-treated rats by diazepam.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Diazepam; Glucose; Kainic Acid; Male; Rats; Rats, | 1987 |
Tolerance to anti-pentylenetetrazol effects following chronic diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Male; Pentylenet | 1986 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippo | 1986 |
Cholinergic induction of seizures in the rat prefrontal cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Clonazepam; Diazepam; Electroencephalography; Male; Microinject | 1986 |
[Hyperlipemia in a neonate following administration of Diazemuls].
Topics: Diazepam; Fat Emulsions, Intravenous; Female; Humans; Hyperlipidemias; Infant, Newborn; Pregnancy; S | 1986 |
Status epilepticus facilitated by pilocarpine in amygdala-kindled rats.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Kindling, Neurologic; Male; Pilocarpine; Rats; Ra | 1986 |
[Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters].
Topics: Acute Disease; Animals; Diazepam; Esters; Male; Organophosphorus Compounds; Phenobarbital; Rats; Rat | 1986 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; | 1986 |
Intraosseous diazepam suppression of pentylenetetrazol-induced epileptogenic activity in pigs.
Topics: Animals; Blood Pressure; Diazepam; Heart Rate; Injections, Intravenous; Pentylenetetrazole; Seizures | 1987 |
Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Electroencephalography; Glutamate Decarboxylase; Male; N | 1986 |
Concomitant increases in the levels of choline and free fatty acids in rat brain: evidence supporting the seizure-induced hydrolysis of phosphatidylcholine.
Topics: Animals; Brain; Choline; Diazepam; Fatty Acids, Nonesterified; Hydrolysis; Male; Phosphatidylcholine | 1987 |
Effects of glycine and other inhibitory amino acid neurotransmitters on strychnine convulsive threshold in mice.
Topics: Alanine; Animals; beta-Alanine; Diazepam; Dose-Response Relationship, Drug; Glycine; Male; Mice; Mic | 1985 |
[The hippocampus as the determinant structure generating epileptic activity during korazol kindling].
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Dimethyl Sulfoxide; Electroencephalography; Ep | 1985 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P | 1985 |
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid | 1985 |
Seizure control following administration of anticonvulsant drugs in the quaking mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Mice; Mice, Inbred C57BL; Mice, Qua | 1985 |
Normeperidine toxicity.
Topics: Adult; Biotransformation; Colonic Neoplasms; Diazepam; Female; Humans; Injections, Intramuscular; Me | 1986 |
Prevention of alcohol withdrawal seizures with oral diazepam loading.
Topics: Adult; Diazepam; Ethanol; Humans; Middle Aged; Seizures; Substance Withdrawal Syndrome | 1985 |
Simultaneous bilateral anterior and posterior shoulder dislocations.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Diazepam; Humans; Male; Middle Aged; Psychoses, Alcoholic; | 1985 |
d-Tubocurarine causes neuronal death when injected directly into rat brain.
Topics: Animals; Biomechanical Phenomena; Blood-Brain Barrier; Brain; Cell Survival; Diazepam; Dose-Response | 1985 |
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminob | 1985 |
Anticonvulsant effects of chronic treatment with phenytoin against pentylenetetrazole-induced seizures in the mouse.
Topics: Animals; Convulsants; Diazepam; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Penty | 1985 |
The effect of diazepam on brain levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine: possible correlation with protection from methionine sulfoximine seizures.
Topics: Animals; Brain Chemistry; Diazepam; Dose-Response Relationship, Drug; Homocysteine; Male; Methionine | 1985 |
Atropine sulfate and 2-pyridine aldoxime methylchloride elicit stress-induced convulsions and lethality in mice and guinea pigs.
Topics: Animals; Atropine; Blood Glucose; Body Temperature; Cold Temperature; Diazepam; Drug Interactions; G | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
Effect of diazepam upon soman-induced seizure activity and convulsions.
Topics: Amygdala; Animals; Atropine; Cholinesterase Inhibitors; Diazepam; Electrocardiography; Electroenceph | 1972 |
Letter: Reactions to lysergide.
Topics: Chlorpromazine; Diazepam; Humans; Lysergic Acid Diethylamide; Seizures | 1974 |
Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention.
Topics: Administration, Oral; Adolescent; Animals; Brain Diseases; Child; Child, Preschool; Diazepam; Epilep | 1974 |
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Appetite Depressants; Behavi | 1974 |
The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one(ID-540).
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Bemegride; Benzodiazepinones; Cats; Chlo | 1974 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepox | 1974 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Elec | 1967 |
Epileptic fits and amitriptyline.
Topics: Amitriptyline; Diazepam; Infusions, Parenteral; Injections, Intramuscular; Seizures | 1968 |
A study of the anti-epileptic action of diazepam (Valium) by focal electrical epilepsy in rabbits with permanent electrodes.
Topics: Animals; Cerebral Cortex; Diazepam; Electrodes; Evoked Potentials; Hippocampus; Rabbits; Seizures; T | 1968 |
Demonstration by a screening method of the exceptional anti-convulsant properties of a new benzodiazepine.
Topics: Benzazepines; Diazepam; Epilepsy; Humans; Hypnotics and Sedatives; Seizures | 1969 |
Metrazol-valium combination for EEG activation.
Topics: Diazepam; Electroencephalography; Humans; Pentylenetetrazole; Seizures | 1970 |
Management of convulsions.
Topics: Child; Diazepam; Epilepsy; Humans; Phenobarbital; Seizures | 1970 |
Management of convulsions.
Topics: Child; Diazepam; Humans; Injections, Intravenous; Phenobarbital; Seizures | 1970 |
The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalogra | 1970 |
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepox | 1973 |
Diazepam prevents and aborts lidocaine convulsions in monkeys.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Injections, | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
[On the mechanism and prevention of the epileptic seizure in an atmosphere of hyperbaric oxygenation in the cat].
Topics: Animals; Cats; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Seizures | 1967 |
The effect of diazepam on different patterns of epileptic electrographic activities in the turtle brain.
Topics: Animals; Cerebral Cortex; Diazepam; Evoked Potentials; Seizures; Thalamus; Turtles | 1974 |
[Early results (initial effects) of the treatment with mogadan in propulsive petit mal epilepsy].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalogra | 1968 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
[Anticonvulsants. 7. Treatment of myclonic-astatic epilepsy in small children].
Topics: Acetazolamide; Adrenocorticotropic Hormone; Child, Preschool; Diazepam; Epilepsy, Absence; Epilepsy, | 1971 |
Classification and treatment of seizure disorders in children.
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, | 1970 |
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous Sy | 1968 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; C | 1969 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central | 1970 |
Method of studying anticonvulsant properties of drugs in man.
Topics: Anticonvulsants; Central Nervous System Stimulants; Diazepam; Heart Rate; Humans; Methods; Seizures; | 1971 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Diazepam blocks cerebral metabolic and circulatory responses to local anesthetic-induced seizures.
Topics: Anesthesia, Local; Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Diazepam; Dogs; Elec | 1974 |
Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Diazepam | 1974 |
Reduction by diazepam of repetitive electrical activity and toxicity resulting from soman.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Diazepam; Drug Synergism; Electrophysiology; Evoked Po | 1974 |
Epileptiform seizures in domestic fowl. IV. The effects of anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Chickens; Diazepam; Electroencephalography; Phenobarbital; Phenytoin; Phot | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
The pharmacology of fletazepam a centrally-acting muscle relaxant.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Benzazepines; Benzodiazepines; Cats; Diaze | 1974 |
Quantitative study of alcohol withdrawal signs in mice.
Topics: Alcoholism; Animals; Barbiturates; Behavior, Animal; Chlorpromazine; Diazepam; Disease Models, Anima | 1973 |
Acute dextropropoxyphene hydrochloride (Darvon) poisoning.
Topics: Adolescent; Brain Damage, Chronic; Dextropropoxyphene; Diazepam; Female; Humans; Nalorphine; Phenoba | 1973 |
Continuous infusion of diazepam in infants with severe recurrent convulsions.
Topics: Acute Disease; Age Factors; Diazepam; Female; Humans; Hypoxia; Infant; Infant, Newborn; Injections, | 1974 |
Brain and serum concentrations of diazepam in experimental epilepsy.
Topics: Acute Disease; Animals; Brain; Cats; Diazepam; Dose-Response Relationship, Drug; Penicillin G; Penty | 1974 |
Seizures associated with the use of meglumine iothalamate 60 per cent in ventriculography.
Topics: Adult; Brain; Cerebral Ventriculography; Child; Curare; Diazepam; Electroencephalography; Female; Hu | 1972 |
[Neuro-psychiatric symptomatology in hypoglycemia].
Topics: Adenoma; Adult; Alcohol Drinking; Atropine; Bipolar Disorder; Coma; Diabetes Complications; Diazepam | 1974 |
Effects of diazepam and phenobarbital on electrically-induced amygdaloid seizures and seizure development.
Topics: Amygdala; Animals; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Imp | 1974 |
Pharmacological studies on 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo-(6,7)-1,4-diazepino(5,4-b)-oxazol-6-one (CS-370), a new psychosedative agent.
Topics: Aggression; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Conditioning | 1972 |
Tonic status epilepticus precipitated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome.
Topics: Adolescent; Benzazepines; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy, Absence; | 1972 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Diazepam treatment of local anesthetic-induced seizures.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Bupivacaine; Diazepam; Dose-Response Relationship, | 1972 |
Intra-arterial valium: its safety and effectiveness.
Topics: Animals; Cerebral Angiography; Diatrizoate; Diazepam; Dogs; Haplorhini; Injections, Intra-Arterial; | 1973 |
Effect of benzodiazepine derivatives on soman-induced seizure activity and convulsions in the monkey.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Diazepam; Dose-Response Relationship, Drug; Electr | 1973 |
[Cerebral convulsions as early signs of delirium tremens].
Topics: Adult; Chloral Hydrate; Chlormethiazole; Diazepam; Electroencephalography; Female; Humans; Male; Mid | 1972 |
Neonatal transitory hypomagnesaemia.
Topics: Calcium; Diazepam; Electrocardiography; Electroencephalography; Humans; Infant; Magnesium; Magnesium | 1972 |
[Encephalitis due to infectious mononucleosis].
Topics: Adult; Antibodies; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Diazepam; Electroencephalograp | 1972 |
Cerebellar involvement in the antiepileptic action of diazepam.
Topics: Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Diazepam; Electrodes, | 1972 |
An animal model for testing effects of drugs on alcohol withdrawal reactions.
Topics: Animals; Ataxia; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Ethanol; Humans; Male; M | 1972 |
Site of action of diazepam in the prevention of lidocaine induced seizure activity in cats.
Topics: Amygdala; Animals; Brain; Cats; Caudate Nucleus; Diazepam; Hippocampus; Lidocaine; Limbic System; Me | 1973 |
Drugs for convulsions.
Topics: Adult; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Seizures; Stevens-Johnso | 1973 |
Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.
Topics: Animals; Calcium; Chlordiazepoxide; Diazepam; Gluconates; Indoles; Male; Melatonin; Parathyroid Glan | 1973 |
Nature and the time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats.
Topics: Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Haloperidol; Male; Parathyroid Glands; Phenytoi | 1973 |
[Convulsions in children].
Topics: Adolescent; Adult; Anticonvulsants; Birth Injuries; Brain Diseases; Brain Injuries; Child; Child, Pr | 1973 |
Chlorpromazine contraindicated in delirium tremens.
Topics: Chlordiazepoxide; Chlorpromazine; Cholestasis; Diazepam; Humans; Psychoses, Alcoholic; Seizures | 1973 |
The management of febrile convulsions.
Topics: Administration, Oral; Aspirin; Child, Preschool; Diazepam; Fever; Humans; Infant; Injections, Intram | 1973 |
Camphorated oil intoxication during pregnancy.
Topics: Adult; Camphor; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal | 1973 |
Diazepam and lidocaine-induced cardiovascular changes.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Diazepam; Drug Interactions; Electrocardiograph | 1973 |
Effects of diazepam on dorsal root potentials induced by cortical paroxysmal activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Blood Pressure; Body Temperature; Cats; Cerebral Cor | 1973 |
Pentylenetetrazol convulsions and brain catecholamine turnover rate in rats and mice receiving diphenylhydantoin or benzodiazepines.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Chemistry; Catecholamines; Cerebellum; Chlordi | 1973 |
Large-dose dimer-x radiculography and thoracic myelography.
Topics: Diazepam; Humans; Intervertebral Disc Displacement; Iothalamic Acid; Lumbosacral Region; Myelography | 1973 |
Side effects of water-soluble contrast media in lumbar myelography.
Topics: Anesthesia, Spinal; Diazepam; Female; Headache; Humans; Hyperesthesia; Hypotension; Iothalamic Acid; | 1973 |
[Cardiovascular complications of tricyclic anti-depressants. Apropos of a case of acute poisoning].
Topics: Adult; Arrhythmias, Cardiac; Bundle-Branch Block; Diazepam; Digitalis Glycosides; Electrocardiograph | 1973 |
Managing emergencies in the newborn.
Topics: Anesthesia, Obstetrical; Anti-Bacterial Agents; Apnea; Bronchopneumonia; Chlorpromazine; Cyclopropan | 1974 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Isoniazid toxicity. Reversal with pyridoxine.
Topics: Adolescent; Diazepam; Humans; Hyperglycemia; Hypothermia; Isoniazid; Lactates; Male; Pyridoxine; Sei | 1974 |
Convulsions induced by local anaesthetic: time course of diazepam prophylaxis.
Topics: Anesthesia, Intravenous; Anesthesia, Local; Animals; Cats; Diazepam; Dose-Response Relationship, Dru | 1974 |
Investigations on the effects of diazepam in acute experimental intoxication with fluostigmine.
Topics: Action Potentials; Animals; Anticonvulsants; Atropine; Diazepam; Drug Combinations; Female; Isofluro | 1974 |
Paroxysmal manifestations generated by a cobalt-induced focus localized within the mesencephalic reticular formation in cats with bilaterally destroyed habenular nuclei.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cobalt; Diazepam; Disease Models, Animal; Electroen | 1974 |
Treatment of febrile convulsions.
Topics: Anticonvulsants; Aspirin; Child; Child, Preschool; Diazepam; Epilepsy, Temporal Lobe; Fever; Humans; | 1974 |
Diazepam prevents local anesthetic seizures.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Blood Circulation; Brain; Cats; Diazepam; Electroence | 1971 |
Diazepam as anticonvulsant in epileptic and normal monkeys.
Topics: Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Haplorhini; Injections, Intramuscular; | 1967 |
Effects of diazepam on secondary subcortical epileptogenic tissues.
Topics: Amygdala; Animals; Cats; Chemical Phenomena; Chemistry; Diazepam; Electroencephalography; Electrophy | 1968 |
[Therapy of long-lasting cerebral swizures and of status epilepticus in childhood].
Topics: Age Factors; Barbiturates; Child; Diazepam; Epilepsy, Tonic-Clonic; Female; Humans; Injections, Intr | 1967 |
Effects of two benzodiazepine derivates on cortical and subcortical epileptogenic tissues in the cat and monkey. 1. Limbic system structures.
Topics: Animals; Anticonvulsants; Benzazepines; Cats; Diazepam; Electroencephalography; Evoked Potentials; H | 1969 |
Effects of two benzodiazepine derivates on cortical and subcortical epileptogenic tissue in the cat and monkey. II. Coetical and centrencephalic structures.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Diazepam; Electroencephalography; Evoked Potentials | 1969 |
[A new animal model in study of the epilepsy: the baboon, Papio papio].
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Electromyography; Evoked Potentials; Eye | 1968 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencepha | 1970 |
[Pharmacological studies of oxazolazepam, a new psychotropic agent. I. Actions on the central nervous system, especially on the behavioral aspect].
Topics: Adaptation, Biological; Analgesics; Anesthesia; Animals; Anticonvulsants; Apomorphine; Avoidance Lea | 1970 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Petit mal status. A variety of non-convulsive status epilepticus.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalograph | 1971 |
Pharmacology of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam; Wy 4036).
Topics: Animals; Behavior, Animal; Benzazepines; Blood Pressure; Cats; Chemical Phenomena; Chemistry; Diazep | 1971 |
[Intravenous use of nitrazepam (Mogadan) in the treatment of epilepsy].
Topics: Administration, Oral; Benzazepines; Child; Child, Preschool; Diazepam; Electroencephalography; Epile | 1970 |
[Cerebral seizures (conclusion). 4. Therapy].
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epileps | 1971 |
[The problem of convulsions in children. Considerations on the use of diazepam by intravenous injection].
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, | 1972 |
Local anesthetic seizure prevention: diazepam versus pentobarbital.
Topics: Anesthesia, Local; Animals; Arousal; Cats; Central Nervous System; Diazepam; Electroencephalography; | 1972 |
Long-term administration of antiepileptic drugs and the development of rickets.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; | 1972 |
Suspected neurotoxicity from intravenous penicillin: a patient case.
Topics: Acute Kidney Injury; Ampicillin; Blood Urea Nitrogen; Chronic Disease; Creatine; Diazepam; Gentamici | 1972 |
Febrile convulsions in early childhood.
Topics: Child; Child, Preschool; Diazepam; Family Practice; Fever; Hospitalization; Humans; Infant; Seizures | 1972 |
To the anticonvulsive action of some psychotropic drugs.
Topics: Diazepam; Dibenzothiazepines; Electroconvulsive Therapy; Humans; Mental Disorders; Phenothiazines; P | 1972 |
Effects of nitrous oxide on the lidocaine seizure threshold and diazepam protection.
Topics: Anesthesia, Local; Animals; Cats; Diazepam; Drug Interactions; Electroencephalography; Lidocaine; Ni | 1972 |
Effects of diazepam on abnormalities of bioelectrical activity of the rabbit's brain due to fluostigmine.
Topics: Animals; Brain; Diazepam; Electrodes, Implanted; Evoked Potentials; Isoflurophate; Organophosphorus | 1972 |
Diagnostic value of diazepam in electroencephalography.
Topics: Adult; Aged; Child; Diazepam; Electroencephalography; Electromyography; Female; Humans; Male; Middle | 1972 |
Anticonvulsive-sedative treatment of delirium alcoholicum.
Topics: Adult; Carbamazepine; Chlordiazepoxide; Chlormethiazole; Diazepam; Dibenzazepines; Drug Synergism; F | 1971 |
[Use of a diazepine derivative in the treatment of toxic convulsions in childhood].
Topics: Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Poisoning; Seizures | 1971 |
[Diagnosis of fever convulsions].
Topics: Body Temperature; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Seizures | 1971 |
[Value of benzodiazepins injected by the intravenous route].
Topics: Benzazepines; Brain Diseases; Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intrav | 1971 |
[Therapy of convulsions in childen by means of the intravenous administration of Faustan (R)].
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Combinations; Drug Synergism; Electroenceph | 1971 |
[Valium in the therapy of epileptic status].
Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male; Se | 1971 |
[Anticonvulsants. 5. Treatment of convulsions in the neonatal period].
Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Phe | 1971 |
Metabolism and anticonvulsant activity of diazepam in guinea pigs.
Topics: Adipose Tissue; Animals; Anticonvulsants; Brain; Chromatography, Gas; Diazepam; Drug Antagonism; Gui | 1971 |
Similarity of diazepam to diphenylhydantoin.
Topics: Diazepam; Humans; Phenytoin; Seizures; Structure-Activity Relationship; Tremor | 1971 |
An intensive one-year study of delirium tremens in Copenhagen from August 1, 1961, to July 31, 1962.
Topics: Adult; Aged; Barbiturates; Blood; Blood Glucose; Bromides; Chlorpromazine; Clinical Enzyme Tests; Co | 1965 |
The use of diazepam in the treatment of status epilepticus.
Topics: Child; Diazepam; Humans; Injections, Intramuscular; Injections, Intravenous; Seizures | 1968 |
The management of eclampsia with intravenous diazepam and protoveratrine.
Topics: Adult; Diazepam; Eclampsia; Female; Humans; Hypertension; Injections, Intravenous; Pregnancy; Protov | 1970 |
Librium and valium.
Topics: Alcoholism; Anxiety; Chlordiazepoxide; Diazepam; Humans; Mental Disorders; Seizures; Suicide | 1969 |
Status epilepticus in infants and young children treated with parenteral diazepam.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Injections, In | 1969 |
[Combined action of diazepam, alpha-methyldopa and reserpine on the effect of pentamethylenetetrazole in mice].
Topics: Animals; Diazepam; Drug Antagonism; Drug Synergism; Male; Methyldopa; Mice; Pentylenetetrazole; Rese | 1969 |
[Action of diazepam on the spinal cord reflex, with special reference to dorsal root reflex].
Topics: Animals; Cats; Chlordiazepoxide; Denervation; Diazepam; Electric Stimulation; Evoked Potentials; Fem | 1969 |
[Seizures in newborn infants].
Topics: Birth Injuries; Cerebral Hemorrhage; Diazepam; Female; Glucose; Humans; Hypernatremia; Hypoglycemia; | 1969 |
Studies on the anticonvulsant action of diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Gas; Diazepam; Mice; Oxazepam; Pen | 1970 |
[Therapy of epileptic mal states].
Topics: Diazepam; Epilepsy; Humans; Seizures | 1970 |
[The use of diazepam in infantile convulsive states].
Topics: Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Seizures | 1970 |
Valium in management of status epilepticus: a correction.
Topics: Diazepam; Epilepsy; Humans; Injections, Intravenous; Seizures | 1970 |
[Truxal intoxication. A case with fatal course].
Topics: Chlorprothixene; Diazepam; Female; Humans; Middle Aged; Phenytoin; Seizures | 1970 |
Pyrrolo[3,2,1-jk][1,4]benzodiazepines and pyrrolo[1,2,3-ef][1,5]benzodiazepines which have central nervous system activity.
Topics: Animals; Behavior, Animal; Benzazepines; Central Nervous System; Chemical Phenomena; Chemistry; Diaz | 1970 |
Electrographic and behavioral effects of diazepam during alcohol withdrawal stage in cats.
Topics: Alcoholic Intoxication; Animals; Brain; Cats; Cerebral Cortex; Diazepam; Electroencephalography; Eth | 1970 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
[Drugs and children. 1. Treatment of seizures in children].
Topics: Adolescent; Barbiturates; Child; Child, Preschool; Chloral Hydrate; Diazepam; Electroencephalography | 1970 |
The antagonism of local anesthetic induced convulsions by the benzodiazepine derivative diazepam.
Topics: Animals; Cats; Diazepam; Drug Antagonism; Electroencephalography; Electromyography; Female; Lidocain | 1970 |
Effects of general depressant drugs on the electrical responses of isolated slabs of cat's cerebral cortex.
Topics: Action Potentials; Aminobutyrates; Anesthesia, General; Anesthesia, Local; Animals; Cats; Cerebral C | 1970 |
Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.
Topics: Adipose Tissue; Animals; Anticonvulsants; Benzazepines; Brain; Brain Chemistry; Chemical Phenomena; | 1970 |
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazol | 1970 |
[Action of several benzodiazepine derivatives (chlordiazepoxide, diazepam, nitrazepam) on audiogenic seizures in mice].
Topics: Animals; Benzazepines; Chlordiazepoxide; Diazepam; Mice; Seizures | 1970 |
Anticonvulsant and motor depressant effects of Diazepam.
Topics: Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Depression, Chemical; Diazepam; D | 1970 |
[Experimental examinations on the convulsive effect of benzyl penicillin, ampicillin and oxacillin].
Topics: Ampicillin; Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Oxacillin; Penicillin G; Ra | 1970 |
Electroclinical aspects of remission of status epilepticus.
Topics: Adult; Alpha Rhythm; Automatism; Barbiturates; Cognition Disorders; Diazepam; Electroencephalography | 1970 |
Intravenous administration of diazepam. Effects on penicillin-induced focal seizures in the cat.
Topics: Animals; Blood Pressure; Cardiovascular System; Cats; Diazepam; Electrocardiography; Electroencephal | 1971 |
Effects of diazepam and pentobarbitone on convulsions induced by local anaesthetics in mice.
Topics: Anesthetics, Local; Animals; Diazepam; Seizures | 1971 |
Strychnine poisoning successfully treated with diazepam.
Topics: Adolescent; Diazepam; Female; Humans; Injections, Intravenous; Poisoning; Seizures; Strychnine | 1971 |
The pharmacology and toxicology of midaflur.
Topics: Analgesics; Animals; Appetite; Avoidance Learning; Benzimidazoles; Body Temperature; Body Weight; Ca | 1971 |
[Experience with a new contrast medium in lumbar myelography].
Topics: Contrast Media; Diazepam; Humans; Myelography; Seizures | 1971 |
Neonatal seizure states: electroencephalography and diazepam.
Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Seizures | 1971 |
[Stellate block. A case with a rare complication].
Topics: Autonomic Nerve Block; Barbiturates; Diazepam; Humans; Lidocaine; Male; Middle Aged; Seizures; Stell | 1967 |
Studies on the anticonvulsant properties of some benzodiazepines. (Chlordiazepoxide, diazepam, oxazepam).
Topics: Action Potentials; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Electroencephalography; Fem | 1967 |
[Injection of barbiturates in status epilepticus].
Topics: Barbiturates; Diazepam; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Seizur | 1968 |
Effect of diazepam (Valium) on experimental seizures in unanesthetized cat.
Topics: Animals; Cats; Cerebral Cortex; Coma; Diazepam; Electroencephalography; Light; Pentylenetetrazole; P | 1968 |
Effects of intravenous diazepam on the electroencephalogram as a means to study seizure mechanisms in man.
Topics: Cerebral Cortex; Diazepam; Electroencephalography; Functional Laterality; Humans; Seizures | 1968 |
Management of prolonged motor seiqure activity in children.
Topics: Child; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Injections, Intravenous; Phenoba | 1968 |
The treatment of prolonged seizure activity with intravenous diazepam.
Topics: Adolescent; Age Factors; Anticonvulsants; Black People; Child; Child, Preschool; Diazepam; Female; H | 1968 |
E.C.T. phases with and without anaesthesia: a preliminary statistical study.
Topics: Amobarbital; Anesthesia; Diazepam; Electroconvulsive Therapy; Epilepsy; Humans; Methohexital; Reacti | 1968 |
The effect of certain benzodaizepines on the threshold for pentylenetetrazol-induced seizures in the cat.
Topics: Animals; Benzazepines; Cats; Chlordiazepoxide; Diazepam; Pentylenetetrazole; Seizures; Time Factors | 1968 |
Certain aspects of pharmacological profiles of chlordiazepoxide and diazepam.
Topics: Analgesics; Animals; Benzazepines; Chlordiazepoxide; Diazepam; Drug Antagonism; Drug Synergism; Elec | 1968 |
[23 convulsions after cesarean section without fatal outcome with administration of diazepam].
Topics: Adolescent; Cesarean Section; Diazepam; Eclampsia; Female; Humans; Pregnancy; Pregnancy, Prolonged; | 1969 |
Data to the anticonvulsive effect of Valium diazepam in experimental hyperoxia and guinea-pig anaphylaxis.
Topics: Anaphylaxis; Animals; Anticonvulsants; Bronchi; Central Nervous System; Diazepam; Electroencephalogr | 1969 |
[Clinical and electroencephalographic findings following intravenously administered benzodiazepin (Valium) in children with convulsions and brain damage].
Topics: Adolescent; Adult; Brain Damage, Chronic; Child; Child, Preschool; Diazepam; Drug Tolerance; Electro | 1969 |
[The convulsive child].
Topics: Acute Disease; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Muscle | 1969 |
Diazepam: its scope in anaesthetic practice.
Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Obstetrical; Cardiac Catheterization; Cardiac Surgic | 1969 |
[Case of idiopathic hypoparathyroidism associated with calcification of the basal ganglia].
Topics: Adult; Basal Ganglia; Calcinosis; Calcium; Cataract; Diazepam; Face; Female; Humans; Hypoparathyroid | 1969 |
Some aspects of the action of valium and of librium on the electrical activity of the rabbit brain.
Topics: Animals; Anticonvulsants; Brain; Chlordiazepoxide; Diazepam; Electroconvulsive Therapy; Electroencep | 1965 |
[Intravenous methyldiazepinone in an epileptic state appearing at the termination of anesthesia].
Topics: Adult; Diazepam; Epilepsy; Female; Humans; Injections, Intravenous; Postoperative Complications; Sei | 1965 |