diazepam has been researched along with Abnormalities, Drug-Induced in 51 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 7.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| " The mother took clonidine during pregnancy." | 7.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 7.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| "The high utilization of diazepam in pregnancy that is not supported by professional guidelines is an issue of serious concern." | 3.76 | The effects of benzodiazepines in pregnancy. ( Culig, J; Eric, M; Leppée, M; Sijanovic, S, 2010) |
| " We studied congenital abnormalities following exposure to phenytoin, phenobarbital, and diazepam in early pregnancy, i." | 3.74 | Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. ( Christensen, J; Czeizel, AE; Horvath-Puhó, E; Kjaer, D; Olsen, J; Sørensen, HT; Vestergaard, M, 2007) |
| " His mother, aged 30 years, has an affective disorder and ingested 30 mg of Diazepam daily, from 3 months previous to the gestation and during the entire pregnancy." | 3.69 | Omphalocele-exstrophy-imperforate-anus-spina bifida (OEIS) complex in a male prenatally exposed to diazepam. ( García-Cruz, D; Lizcano-Gil, LA; Sánchez-Corona, J, 1995) |
| " Diazepam (Valium) could cause cleft palate by mimicking GABA." | 3.67 | Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development. ( Zimmerman, EF, 1984) |
| " Diazepam may cause cleft palate by mimicking GABA." | 3.67 | Role of neurotransmitters and teratogens on palate development. ( Venkatasubramanian, K; Wee, EL; Zimmerman, EF, 1985) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| " The mother took clonidine during pregnancy." | 3.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 3.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| "Treatment with diazepam ameliorated the spasms, while treatment with the sodium channel antagonist MS-222 ameliorated both spasms and body curvature, suggesting that pyrethroid-induced neurotoxicity is similar in zebrafish and mammals." | 1.36 | Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos. ( Cooper, KR; DeMicco, A; Richardson, JR; White, LA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (82.35) | 18.7374 |
| 1990's | 6 (11.76) | 18.2507 |
| 2000's | 1 (1.96) | 29.6817 |
| 2010's | 2 (3.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeMicco, A | 1 |
| Cooper, KR | 1 |
| Richardson, JR | 1 |
| White, LA | 1 |
| Leppée, M | 1 |
| Culig, J | 1 |
| Eric, M | 1 |
| Sijanovic, S | 1 |
| Kjaer, D | 1 |
| Horvath-Puhó, E | 1 |
| Christensen, J | 1 |
| Vestergaard, M | 1 |
| Czeizel, AE | 1 |
| Sørensen, HT | 1 |
| Olsen, J | 1 |
| Zimmerman, EF | 3 |
| Saito, H | 1 |
| Kobayashi, H | 1 |
| Takeno, S | 1 |
| Sakai, T | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Shiono, PH | 1 |
| Mills, JL | 1 |
| Rivas, F | 1 |
| Hernandez, A | 1 |
| Cantu, JM | 1 |
| Entman, SS | 1 |
| Vaughn, WK | 1 |
| Poskitt, EM | 1 |
| Hensey, OJ | 1 |
| Smith, CS | 1 |
| Zenk, KE | 1 |
| Nagele, RG | 1 |
| Pietrolungo, JF | 1 |
| Lee, H | 1 |
| Roisen, F | 1 |
| Evans, AN | 1 |
| Brooke, OG | 1 |
| West, RJ | 1 |
| Oakley, GP | 2 |
| Lizcano-Gil, LA | 1 |
| García-Cruz, D | 1 |
| Sánchez-Corona, J | 1 |
| Benesová, O | 1 |
| Tejkalová, H | 1 |
| Kristofiková, Z | 1 |
| Dostál, M | 1 |
| Husek, P | 1 |
| Safra, MJ | 1 |
| Saxén, I | 2 |
| Saxén, L | 1 |
| Crombie, DL | 1 |
| Pinsent, RJ | 1 |
| Fleming, DM | 1 |
| Rumeau-Rouquette, C | 1 |
| Goujard, J | 1 |
| Huel, G | 1 |
| Scrollini, F | 1 |
| Caliari, S | 1 |
| Romano, A | 1 |
| Torchio, P | 1 |
| Shah, RM | 1 |
| Donaldson, D | 1 |
| Burdett, D | 1 |
| Bruni, J | 1 |
| Willmore, LJ | 1 |
| Stoll, C | 1 |
| Levy, JM | 1 |
| Beshara, D | 1 |
| Lakos, P | 1 |
| Czeizel, E | 1 |
| Canfield, PR | 1 |
| Stenchever, MA | 1 |
| Parks, KJ | 1 |
| Lunde, I | 2 |
| Borchgrevink, CF | 1 |
| Waziri, M | 1 |
| Ionasescu, V | 1 |
| Zellweger, H | 1 |
| Rosenberg, JM | 1 |
| Brochgrevink, CF | 1 |
| Warkany, J | 1 |
| Shaul, WL | 1 |
| Emery, H | 1 |
| Hall, JG | 1 |
| Miller, RP | 1 |
| Becker, BA | 1 |
| Laegreid, L | 1 |
| Hagberg, G | 1 |
| Lundberg, A | 1 |
| Courtens, W | 1 |
| Vamos, E | 1 |
| Hainaut, M | 1 |
| Vergauwen, P | 1 |
| Hernández-Alvarez, LA | 1 |
| Márquez-Orozco, MC | 1 |
| Márquez-Orozco, A | 1 |
| Mehanny, SZ | 1 |
| Abdel-Rahman, MS | 1 |
| Ahmed, YY | 1 |
| Venkatasubramanian, K | 1 |
| Wee, EL | 1 |
| Wladimiroff, JW | 1 |
| Stewart, PA | 1 |
| Reuss, A | 1 |
| van Swaay, E | 1 |
| Lindhout, D | 1 |
| Sachs, ES | 1 |
| Kellogg, CK | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Rothstein, P | 1 |
| Gould, JB | 1 |
| Cameron, JM | 1 |
| Ringrose, CA | 1 |
| Beall, JR | 1 |
| Baumgartner, S | 1 |
| Istvan, EJ | 1 |
4 reviews available for diazepam and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Effects of drugs and chemicals on the fetus and newborn (2).
Topics: Abnormalities, Drug-Induced; Anticoagulants; Anticonvulsants; Diazepam; Drug-Related Side Effects an | 1984 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo | 1981 |
Drugs and chemicals that act on the central nervous system: interpretation of experimental evidence.
Topics: Abnormalities, Drug-Induced; Animals; Binding Sites; Brain; Central Nervous System Agents; Diazepam; | 1985 |
Advances in toxicology.
Topics: Abnormalities, Drug-Induced; Animals; Antidepressive Agents; Barbiturates; Cannabis; Diazepam; Drug | 1971 |
47 other studies available for diazepam and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos.
Topics: Abnormalities, Drug-Induced; Aminobenzoates; Animals; Biological Assay; Craniofacial Abnormalities; | 2010 |
The effects of benzodiazepines in pregnancy.
Topics: Abnormalities, Drug-Induced; Anti-Anxiety Agents; Anxiety; Cardiovascular Diseases; Diazepam; Female | 2010 |
Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Case-Control Studies; Cross-Over Studies; Diaze | 2007 |
Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Animals; Cell Movement; Cleft Palate; Diazepam; Dopamine | 1984 |
Fetal toxicity of benzodiazepines in rats.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Clonazepam; Diazepam; F | 1984 |
Oral clefts and diazepam use during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Palate; Diazepam; Female; Fetus; Humans; Infant, Newborn; Pregnan | 1984 |
Acentric craniofacial cleft in a newborn female prenatally exposed to a high dose of diazepam.
Topics: Abnormalities, Drug-Induced; Diazepam; Face; Female; Humans; Infant, Newborn; Pregnancy; Prenatal Ex | 1984 |
Lack of relation of oral clefts to diazepam use in pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1984 |
Alcohol, other drugs and the fetus.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Dextropropoxyphene; Diazepam; Drug Synergism; Female; Fe | 1982 |
Risk taking and a minor birth defect.
Topics: Abnormalities, Drug-Induced; Adult; Anxiety; Diazepam; Female; Genetic Counseling; Humans; Person-Ce | 1981 |
Diazepam-induced neural tube closure defects in explanted early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chick Embryo; Diazepam; Dose-Response Relationship, Dru | 1981 |
The ingestion by pregnant women of substances toxic to the foetus.
Topics: Abnormalities, Drug-Induced; Barbiturates; Clitoris; Diazepam; Disorders of Sex Development; Doxylam | 1980 |
Causal inference in teratology.
Topics: Abnormalities, Drug-Induced; Alcoholic Beverages; Diazepam; Epidemiologic Methods; Female; Humans; I | 1980 |
Omphalocele-exstrophy-imperforate-anus-spina bifida (OEIS) complex in a male prenatally exposed to diazepam.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anus, Imperforate; Bladder Exstrophy; D | 1995 |
[Perinatal pharmacotherapy and the risk of functional teratogenic defects].
Topics: Abnormalities, Drug-Induced; Animals; Dexamethasone; Diazepam; Female; Fenoterol; Humans; Pregnancy; | 1995 |
Association between cleft lip with or without cleft palate and prenatal exposure to diazepam.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Maternal-Fetal Excha | 1975 |
Letter: Association between maternal intake of diazepam and oral clefts.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant; Infant, Newb | 1975 |
Letter: Fetal effects of tranquilizers in pregnancy.
Topics: Abnormalities, Drug-Induced; Anti-Anxiety Agents; Carbamates; Chlordiazepoxide; Diazepam; Female; He | 1975 |
Toxicological and pharmacological investigations of pinazepam (7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one): a new psychotherapeutic agent.
Topics: Abnormalities, Drug-Induced; Aggression; Analgesia; Animals; Anti-Anxiety Agents; Blood Pressure; Ca | 1975 |
Teratogenic effects of diazepam in the hamster.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Cricetinae; Diazepam; Dose-Response Rela | 1979 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
Roberts's syndrome and clonidine.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Lip; Cleft Palate; Clonidine; Diazepam; | 1979 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
Teratogenic effects of drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Palate; Diazepam; Female; Genitalia, Male; Humans; Male; Pregnanc | 1978 |
Some effects of diazepam on pregnancy in the Balb/C mouse.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anophthalmos; Body Weight; Diazepam; Ear | 1975 |
[Use of diazepam in early pregnancy].
Topics: Abnormalities, Drug-Induced; Diazepam; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Trimest | 1976 |
Teratogenic effect of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Anticonvulsants; Child; Child, | 1976 |
Is it safe to utilize minor tranquilizers such as Librium, Valium, and meprobamate during pregnancy?
Topics: Abnormalities, Drug-Induced; Chlordiazepoxide; Diazepam; Female; Humans; Meprobamate; Pregnancy | 1975 |
[Use of diazepam in early pregnancy].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1976 |
Associations between oral clefts and drugs taken during pregnancy.
Topics: Abnormalities, Drug-Induced; Analgesics; Anticonvulsants; Chloramphenicol; Cleft Lip; Cleft Palate; | 1975 |
A warfarin embryopathy?
Topics: Abnormalities, Drug-Induced; Alcoholism; Chondrodysplasia Punctata; Diazepam; Digitalis Glycosides; | 1975 |
Chondrodysplasia punctata and maternal warfarin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Alcoholism; Cerebrovascular Disorders; Chondrodysplasia Punctata; Contr | 1975 |
Teratogenicity of oral diazepam and diphenylhydantoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu | 1975 |
Neurodevelopment in late infancy after prenatal exposure to benzodiazepines--a prospective study.
Topics: Abnormalities, Drug-Induced; Anti-Anxiety Agents; Arousal; Body Height; Body Weight; Cephalometry; D | 1992 |
Moebius syndrome in an infant exposed in utero to benzodiazepines.
Topics: Abnormalities, Drug-Induced; Diazepam; Face; Female; Humans; Infant, Newborn; Syndrome | 1992 |
Effects of prenatal administration of diazepam on the ovary of mice.
Topics: Abnormalities, Drug-Induced; Animals; Diazepam; Female; Mice; Ovary; Pregnancy; Prenatal Exposure De | 1991 |
Teratogenic effect of cocaine and diazepam in CF1 mice.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Cocaine; Diazepam; Drug Interactions; Em | 1991 |
Role of neurotransmitters in palate development and teratologic implications.
Topics: Abnormalities, Drug-Induced; Animals; Biological Transport, Active; Cleft Palate; Diazepam; Female; | 1985 |
Role of neurotransmitters and teratogens on palate development.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cell Movement; Cleft Palate; Diazepam; g | 1985 |
In-utero exposure to benzodiazepines.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Benzodiazepines; Diazepam; Female; Humans; Inf | 1987 |
The role of ultrasound in the early diagnosis of fetal structural defects following maternal anticonvulsant therapy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Diazepam; Female; Humans; Infant, Newbo | 1988 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
The hazard of neurotropic drugs in the fertile years.
Topics: Abnormalities, Drug-Induced; Dextropropoxyphene; Diazepam; Female; Humans; Meprobamate; Phenytoin; P | 1972 |
Study of the teratogenic potential of diazepam and SCH 12041.
Topics: Abnormalities, Drug-Induced; Animals; Benzazepines; Birth Weight; Diazepam; Female; Pregnancy; Pregn | 1972 |
[Medication in pregnancy and labor].
Topics: Abnormalities, Drug-Induced; Abortion, Threatened; Asphyxia Neonatorum; Diazepam; Erythroblastosis, | 1972 |
Drug-associated congenital abnormalities?
Topics: Abnormalities, Drug-Induced; Diazepam; Female; Humans; Hydroxyprogesterones; Infant, Newborn; Pregna | 1970 |