diazepam and Abdominal Epilepsy studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

Excerpt	Relevance	Reference
"A 19-year-old male came to the Emergency Room of our hospital due to an episode of dystonic movements and disorientation 4 days after consuming methamphetamine, which evolved to a catatonic frank syndrome and eventually to status epilepticus."	3.85	Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis. ( Aguilera, L; García, JM; Iriondo, O; Rodríguez, T; Zaldibar-Gerrikagoitia, J, 2017)
"When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone."	2.67	The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991)
"Drug treatment of status epilepticus is reviewed."	2.36	Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978)
"Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures."	2.35	Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976)
"Chronic focal epilepsy was induced by injecting 25-50 ng of tetanus toxin or vehicle alone (controls) into the motor neocortex of rats."	1.33	Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. ( Cock, HR; Nilsen, KE; Walker, MC, 2005)
"Interictally, a dense homonymous hemianopia was demonstrated in the clinical examination and by using perimetry, but was not recognized by the patient himself."	1.31	Ictal visual hallucinations and post-ictal hemianopia with anosognosia. ( Mamoli, B; Spatt, J, 2000)
"Midazolam (0."	1.28	Intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model. ( Bittle, BK; Jaimovich, DG; Noorani, PA; Osborne, JS; Shabino, CL, 1990)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (58.14)	18.7374
1990's	6 (13.95)	18.2507
2000's	10 (23.26)	29.6817
2010's	2 (4.65)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Godlevsky, LS	1
Drozdova, GA	1
Kobolev, EV	1
Mustyatsa, VF	1
Polyasnyi, VA	1
Iriondo, O	1
Zaldibar-Gerrikagoitia, J	1
Rodríguez, T	1
García, JM	1
Aguilera, L	1
Ito, Y	1
Oguni, H	1
Funatsuka, M	2
Osawa, M	1
Claus, S	1
Leijten, F	1
Kallansee, P	1
Klepper, J	1
Lopes da Silva, FH	1
Ronner, H	1
Velis, D	1
Viergever, MA	1
Kalitzin, S	1
McCusker, CG	1
Kennedy, PJ	1
Anderson, J	1
Hicks, EM	1
Hanrahan, D	1
Macdonald, RL	1
Bianchi, MT	1
Bianch, MT	1
Feng, H	1
Managoli, S	1
Vilhekar, KY	1
Nilsen, KE	1
Walker, MC	1
Cock, HR	1
Ricci, GB	1
De Carli, D	1
Colonnese, C	1
Di Gennaro, G	1
Quarato, PP	1
Cantore, G	1
Esposito, V	1
Garreffa, G	1
Maraviglia, B	1
Parisi, P	1
Kasteleijn-Nolst Trenité, DG	1
Piccioli, M	1
Pelliccia, A	1
Luchetti, A	1
Buttinelli, C	1
Villa, MP	1
Mimaki, T	1
Tagawa, T	1
Ono, J	1
Tanaka, J	1
Terada, H	1
Itoh, N	1
Yabuuchi, H	1
Rothner, AD	1
Erenberg, G	1
Browne, TR	4
Scholtes, FB	1
Renier, WO	1
Meinardi, H	2
Eder, HG	1
Jones, DB	1
Fisher, RS	1
Kato, H	1
Kishikawa, H	1
Emura, S	1
Takashima, T	1
Ohmori, K	1
Fujita, H	1
Spatt, J	1
Mamoli, B	1
Prevec, TS	1
Ito, T	1
Hori, M	1
Yoshida, K	1
Shimizu, M	1
Gartside, IB	1
Gibberd, FB	1
Tempfer, H	1
Hougaard, K	1
Oikawa, T	2
Sveinsdottir, E	1
Skinoj, E	1
Ingvar, DH	1
Lassen, NA	1
Hart, YM	1
Sander, JW	1
Nutt, DJ	1
Shorvon, SD	1
Oki, J	1
Itoh, J	1
Kusunoki, Y	1
Cho, K	1
Jaimovich, DG	1
Shabino, CL	1
Noorani, PA	1
Bittle, BK	1
Osborne, JS	1
Parish, RA	1
Brownstein, D	1
Laitinen, L	1
Toivakka, E	1
van Duijn, H	2
Penry, JK	1
Edmonds, HL	1
Stark, LG	1
Hollinger, MA	1
Kutt, H	1
Louis, S	1
Visser, SL	1
Bell, DS	1
Nicol, CF	1
Tutton, JC	1
Smith, BH	1
Elian, M	1
Niedermeyer, E	2
Borkowska, Z	1
Mazurkowa, K	1
Wojakowski, A	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Trial of Intracerebral Infusion in Patients With Medically Intractable Epilepsy[NCT00005925]			Phase 1	3 participants (Actual)	Interventional	2000-06-23	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Clinical and EEG studies of symptomatic focal epilepsy in 7 patients with colpocephaly]. No to hattatsu = Brain and development, 2008, Volume: 40, Issue:3 Topics: Adult; Anticonvulsants; Benzodiazepines; Cerebral Ventricles; Child; Diazepam; Electroencephalograph	2008
[Early-onset benign occipital seizure susceptibility syndrome(EBOSS)]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epil	2002
Drug therapy reviews: drug therapy of status epilepticus. American journal of hospital pharmacy, 1978, Volume: 35, Issue:8 Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil	1978
Clonazepam. A review of a new anticonvulsant drug. Archives of neurology, 1976, Volume: 33, Issue:5 Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To	1976
Benzodiazepines in the treatment of epilepsy. A review. Epilepsia, 1973, Volume: 14, Issue:3 Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec	1973

Article	Year
Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy. Bulletin of experimental biology and medicine, 2013, Volume: 154, Issue:3 Topics: Animals; Anticonvulsants; Brain; Brain Waves; Cerebral Cortex; Diazepam; Drug Synergism; Epilepsies,	2013
Anti-NMDA (a-NMDAR) receptor encephalitis related to acute consumption of metamphetamine: Relevance of differential diagnosis. Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:3 Topics: Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Anticonvulsants; Autoantibodies; Benzodiazepines; C	2017
An electro-encephalogram beta gap after induction with diazepam: a localization method in epileptogenic lesions. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2009, Volume: 120, Issue:7 Topics: Algorithms; Anticonvulsants; Benzodiazepines; Beta Rhythm; Diazepam; Electroencephalography; Epileps	2009
Adjustment in children with intractable epilepsy: importance of seizure duration and family factors. Developmental medicine and child neurology, 2002, Volume: 44, Issue:10 Topics: Adaptation, Psychological; Administration, Rectal; Anticonvulsants; Child; Child Behavior Disorders;	2002
Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current. Experimental neurology, 2003, Volume: 184 Suppl 1 Topics: Amino Acids, Basic; Animals; Cell Line; Diazepam; Dose-Response Relationship, Drug; Drug Interaction	2003
Tricotillomania as an ictal manifestation of partial seizure in a 4-year-old girl. Indian journal of pediatrics, 2003, Volume: 70, Issue:10 Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsies, Partial; Female; H	2003
Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. Epilepsia, 2005, Volume: 46, Issue:2 Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Electroencephal	2005
Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect. Magnetic resonance imaging, 2004, Volume: 22, Issue:10 Topics: Adult; Anticonvulsants; Brain; Diazepam; Echo-Planar Imaging; Electroencephalography; Epilepsies, Pa	2004
A case with atypical childhood occipital epilepsy "Gastaut type": an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia, 2007, Volume: 48, Issue:11 Topics: Adolescent; Anticonvulsants; Comorbidity; Diazepam; Electroencephalography; Epilepsies, Partial; Epi	2007
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures. Brain & development, 1984, Volume: 6, Issue:6 Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota	1984
Status epilepticus. Pediatric clinics of North America, 1980, Volume: 27, Issue:3 Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial;	1980
Therapy of status epilepticus. Comprehensive therapy, 1982, Volume: 8, Issue:5 Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy	1982
Simple partial status epilepticus: causes, treatment, and outcome in 47 patients. Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 61, Issue:1 Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsies, Partial; Female; Humans; Injec	1996
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats. Epilepsia, 1997, Volume: 38, Issue:5 Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Do	1997
Treatment of focal status epilepticus with lignocaine. Journal of accident & emergency medicine, 1997, Volume: 14, Issue:3 Topics: Aged; Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Generalized; Humans; Lidocaine; Male	1997
Ictal visual hallucinations and post-ictal hemianopia with anosognosia. Seizure, 2000, Volume: 9, Issue:7 Topics: Aged; Aged, 80 and over; Anticonvulsants; Diazepam; Electroencephalography; Epilepsia Partialis Cont	2000
[Effects of Valium on evoked cerebral cortex activity]. Neurologija, 1977, Volume: 25, Issue:1-2 Topics: Cerebral Cortex; Child; Diazepam; Electric Stimulation; Epilepsies, Partial; Evoked Potentials; Huma	1977
Effect of anticonvulsants on cortical focal seizure in cats. Epilepsia, 1977, Volume: 18, Issue:1 Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps	1977
The actions of diazepam and phenytoin on a low dose penicillin epileptiform focus in the anaesthetised rat. British journal of pharmacology, 1978, Volume: 62, Issue:2 Topics: Animals; Diazepam; Electroencephalography; Epilepsies, Partial; Penicillin G; Phenytoin; Rats	1978
Diseases of the central nervous system: Epilepsy. British medical journal, 1975, Nov-01, Volume: 4, Issue:5991 Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth	1975
[Jacksonian fits and threatened premature labour (the effect of valium, prepar and antiepileptic drugs on the fetus and uterine contractility ante and intra partum) (author's transl)]. Wiener klinische Wochenschrift, 1975, Dec-12, Volume: 87, Issue:23 Topics: Adult; Anticonvulsants; Astrocytoma; Diazepam; Epilepsies, Partial; Female; Fetus; Humans; Muscle Co	1975
Regional cerebral blood flow in focal cortical epilepsy. Archives of neurology, 1976, Volume: 33, Issue:8 Topics: Adult; Aged; Brain Neoplasms; Cerebral Cortex; Cerebrovascular Circulation; Diazepam; Electroencepha	1976
[Cerebral blood flow in focal cortical epilepsy, with special reference to the pathophysiology of epileptic foci during functional tests]. No to shinkei = Brain and nerve, 1976, Volume: 28, Issue:4 Topics: Adult; Aged; Angiotensin II; Cerebrovascular Circulation; Diazepam; Electroencephalography; Epilepsi	1976
[Exacerbation of partial seizures in a case with heterotopic gray matter using antiepileptic drugs]. No to hattatsu = Brain and development, 1991, Volume: 23, Issue:4 Topics: Brain; Brain Neoplasms; Carbamazepine; Child, Preschool; Choristoma; Diazepam; Electroencephalograph	1991
Intravenous midazolam suppression of pentylenetetrazol-induced epileptogenic activity in a porcine model. Critical care medicine, 1990, Volume: 18, Issue:3 Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Diazepam; Electroencephalography; Ep	1990
Emergency department management of children with acute isoniazid poisoning. Pediatric emergency care, 1986, Volume: 2, Issue:2 Topics: Adolescent; Child; Diazepam; Emergencies; Epilepsies, Partial; Epilepsy, Temporal Lobe; Epilepsy, To	1986
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec	1973
Superiority of clonazepam over diazepam in experimental epilepsy. Epilepsia, 1973, Volume: 14, Issue:2 Topics: Animals; Anticonvulsants; Bemegride; Benzazepines; Cats; Cobalt; Diazepam; Disease Models, Animal; E	1973
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat. Experimental neurology, 1974, Volume: 45, Issue:2 Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence	1974
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects. Drugs, 1972, Volume: 4, Issue:3 Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog	1972
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats. Epilepsia, 1972, Volume: 13, Issue:3 Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography;	1972
Dangers of treatment of status epilepticus with diazepam. British medical journal, 1969, Jan-18, Volume: 1, Issue:5637 Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa	1969
Parenteral diazepam in status epilepticus. Neurology, 1969, Volume: 19, Issue:4 Topics: Adolescent; Adult; Aged; Alcoholism; Brain Neoplasms; Child; Child, Preschool; Diazepam; Electroence	1969
The long-term oral use of valium (diazepam) in epilepsy. Epilepsia, 1969, Volume: 10, Issue:4 Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Partial; E	1969
Electroencephalographic studies on the anticonvulsive action of intravenous diazepam. European neurology, 1970, Volume: 3, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epile	1970
Intravenous diazepam and its anticonvulsive action. The Johns Hopkins medical journal, 1970, Volume: 127, Issue:2 Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography;	1970
[Results of treatment of epilepsy in children up to 14 years of age]. Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3 Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc	1971

diazepam and Abdominal Epilepsy

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies