diamide and Cystinuria

diamide has been researched along with Cystinuria* in 1 studies

Other Studies

1 other study(ies) available for diamide and Cystinuria

ArticleYear
l-Cystine Diamides as l-Cystine Crystallization Inhibitors for Cystinuria.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    l-Cystine bismorpholide (1a) and l-cystine bis(N'-methylpiperazide) (1b) were seven and twenty-four times more effective than l-cystine dimethyl ester (CDME) in increasing the metastable supersaturation range of l-cystine, respectively, effectively inhibiting l-cystine crystallization. This behavior can be attributed to inhibition of crystal growth at microscopic length scale, as revealed by atomic force microscopy. Both 1a and 1b are more stable than CDME, and 1b was effective in vivo in a knockout mouse model of cystinuria.

    Topics: Administration, Oral; Amino Acid Transport Systems, Basic; Amino Acid Transport Systems, Neutral; Animals; Cystine; Cystinuria; Diamide; Disease Models, Animal; Male; Mice; Mice, Knockout; Models, Molecular; Molecular Structure

2016