diacetyl has been researched along with Bronchiolitis, Exudative in 50 studies
butane-2,3-dione : An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis." | 7.80 | Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. ( Beasley, RF; Fischer, BM; Gwinn, WM; Kelly, FL; Kummarapurugu, AB; Martinu, T; Morgan, DL; Nugent, JL; Palmer, SM; Sun, J; Voynow, JA; Zhang, HL, 2014) |
| "Workers in microwave popcorn plants are at risk of developing bronchiolitis obliterans associated with exposure to butter flavoring volatiles, including diacetyl." | 7.74 | Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. ( Heederik, DJ; Houba, R; Prokop, M; Rooyackers, JM; Smit, LA; van Rooy, FG, 2007) |
| "Occupational exposure to the diacetyl flavoring may cause bronchiolitis obliterans (BO) in workers." | 5.05 | [Advances in flavoring-related bronchiolitis obliterans]. ( Wang, YY; Ye, Q, 2020) |
| "Inhalation of diacetyl-containing products is associated with risk for occupational bronchiolitis obliterans (BO) and fixed airways obstruction, particularly in workers exposed to heated liquids and powdered formulations." | 4.95 | Early detection, clinical diagnosis, and management of lung disease from exposure to diacetyl. ( Rose, CS, 2017) |
| "Diacetyl and 2,3-pentanedione inhalation have been suggested as causes of severe respiratory disease, including bronchiolitis obliterans, in food/flavoring manufacturing workers." | 4.90 | Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers. ( Abelmann, A; Adams, RE; Finley, BL; Pierce, JS; Spicer, LJ, 2014) |
| "Occupational exposure to diacetyl can lead to bronchiolitis obliterans." | 4.31 | [Two cases of airway dysfunction related to diacetyl exposure]. ( Chen, LN; Dai, LY; Hu, BH; Huang, XP; Mao, GC; Yu, XP, 2023) |
| "The butter flavoring additive, diacetyl (DA), can cause bronchiolitis obliterans (BO) by inhalation." | 3.88 | Pulmonary Impairment and Risk Assessment in a Diacetyl-Exposed Population: Microwave Popcorn Workers. ( Gilbert, SJ; Park, RM, 2018) |
| "Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis." | 3.80 | Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. ( Beasley, RF; Fischer, BM; Gwinn, WM; Kelly, FL; Kummarapurugu, AB; Martinu, T; Morgan, DL; Nugent, JL; Palmer, SM; Sun, J; Voynow, JA; Zhang, HL, 2014) |
| "Four diacetyl workers were found to have bronchiolitis obliterans syndrome." | 3.75 | A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. ( Heederik, DJ; Houba, R; Rooyackers, JM; Smit, LA; van Rooy, FG; Zaat, VA, 2009) |
| "Occupational exposures to the butter flavouring agent diacetyl (2,3-butanedione) have caused lung inflammation and severe airflow limitation due to bronchiolitis obliterans." | 3.75 | Acute airway effects of diacetyl in mice. ( Alarie, Y; Hammer, M; Larsen, ST; Nielsen, GD, 2009) |
| "Recently, worker exposures to diacetyl, a chemical used in the production of butter popcorn, has been linked to bronchiolitis obliterans, a severe lung disease." | 3.74 | Diacetyl exposures in the flavor manufacturing industry. ( Arbuckle, S; Martyny, JW; Rose, CS; Towle, M; Van Dyke, MV, 2008) |
| "Bronchiolitis obliterans, a rare and life-threatening form of fixed obstructive lung disease, is known to be caused by exposure to noxious gases in occupational settings and has been described in workers in the microwave-popcorn industry who were exposed to artificial butter-flavoring chemicals, including diacetyl." | 3.74 | Fixed obstructive lung disease among workers in the flavor-manufacturing industry--California, 2004-2007. ( , 2007) |
| "Workers in microwave popcorn plants are at risk of developing bronchiolitis obliterans associated with exposure to butter flavoring volatiles, including diacetyl." | 3.74 | Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. ( Heederik, DJ; Houba, R; Prokop, M; Rooyackers, JM; Smit, LA; van Rooy, FG, 2007) |
| " ET is a common feature of toxic substances, usually involving their metabolites which can operate per se or through reactions that generate ROS and oxidative stress (OS)." | 2.46 | Electron transfer as a potential cause of diacetyl toxicity in popcorn lung disease. ( Cooksy, AL; Kovacic, P, 2010) |
| "Diacetyl is a diketone flavouring agent that is commonly employed for buttery taste as well as other purposes." | 2.43 | Diacetyl-induced lung disease. ( Boomus, C; Harber, P; Saechao, K, 2006) |
| "Shortness of breath was twice as common in those with tenure ≥ 7 years (OR 2." | 1.40 | Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility. ( Boylstein, RJ; Cummings, KJ; Edwards, NT; Kreiss, K; LeBouf, RF; Piacitelli, CA; Stanton, ML, 2014) |
| "Diacetyl was found to be the most predominant of these compounds." | 1.35 | A case of flavor-induced lung disease. ( Balk, RA; Khasawaneh, F; Modi, P; Sreedhar, R; Yadava, V, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (40.00) | 29.6817 |
| 2010's | 24 (48.00) | 24.3611 |
| 2020's | 6 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Virji, MA | 1 |
| Cummings, KJ | 4 |
| Cox-Ganser, JM | 4 |
| McGraw, MD | 2 |
| Yee, M | 1 |
| Kim, SY | 2 |
| Dylag, AM | 1 |
| Lawrence, BP | 1 |
| O'Reilly, MA | 1 |
| Hu, BH | 1 |
| Huang, XP | 1 |
| Yu, XP | 1 |
| Chen, LN | 1 |
| Dai, LY | 1 |
| Mao, GC | 1 |
| Hubbs, AF | 1 |
| Kreiss, K | 11 |
| Fluharty, KL | 1 |
| O'Connell, R | 1 |
| Cole, A | 1 |
| Dodd, TM | 1 |
| Clingerman, SM | 1 |
| Flesher, JR | 1 |
| Lee, R | 1 |
| Pagel, S | 1 |
| Battelli, LA | 1 |
| Cumpston, A | 1 |
| Jackson, M | 1 |
| Kashon, M | 1 |
| Orandle, MS | 1 |
| Fedan, JS | 1 |
| Sriram, K | 1 |
| Wang, YY | 1 |
| Ye, Q | 1 |
| Wang, J | 1 |
| House, E | 1 |
| Olson, HM | 1 |
| Johnston, CJ | 1 |
| Chalupa, D | 1 |
| Hernady, E | 1 |
| Mariani, TJ | 1 |
| Clair, G | 1 |
| Ansong, C | 1 |
| Qian, WJ | 1 |
| Finkelstein, JN | 1 |
| Harvey, RR | 1 |
| Blackley, BH | 1 |
| Korbach, EJ | 1 |
| Rawal, AX | 1 |
| Roggli, VL | 1 |
| Bailey, RL | 3 |
| Rose, CS | 2 |
| Gwinn, WM | 3 |
| Flake, GP | 3 |
| Bousquet, RW | 1 |
| Taylor, GJ | 1 |
| Morgan, DL | 5 |
| Galbraith, DA | 3 |
| Park, RM | 1 |
| Gilbert, SJ | 1 |
| Kelly, FL | 3 |
| Weinberg, KE | 1 |
| Nagler, AE | 1 |
| Nixon, AB | 1 |
| Star, MD | 1 |
| Todd, JL | 1 |
| Brass, DM | 1 |
| Palmer, SM | 3 |
| Brooks, SM | 1 |
| Pierce, JS | 1 |
| Abelmann, A | 1 |
| Spicer, LJ | 1 |
| Adams, RE | 1 |
| Finley, BL | 1 |
| Sun, J | 1 |
| Fischer, BM | 1 |
| Voynow, JA | 1 |
| Kummarapurugu, AB | 1 |
| Zhang, HL | 2 |
| Nugent, JL | 2 |
| Beasley, RF | 1 |
| Martinu, T | 1 |
| Boylstein, RJ | 1 |
| Stanton, ML | 1 |
| Piacitelli, CA | 1 |
| Edwards, NT | 1 |
| LeBouf, RF | 3 |
| Starek-Swiechowicz, B | 1 |
| Starek, A | 1 |
| Duling, MG | 2 |
| Martin, SB | 2 |
| Bledsoe, TA | 1 |
| Green, BJ | 1 |
| Galbraith, D | 1 |
| Weill, D | 3 |
| Martyny, JW | 1 |
| Van Dyke, MV | 1 |
| Arbuckle, S | 1 |
| Towle, M | 1 |
| van Rooy, FG | 2 |
| Smit, LA | 2 |
| Houba, R | 2 |
| Zaat, VA | 1 |
| Rooyackers, JM | 2 |
| Heederik, DJ | 2 |
| Rangan, C | 1 |
| Barceloux, DG | 1 |
| Dulberg, AS | 1 |
| Harber, P | 2 |
| Harrison, R | 1 |
| Gelb, A | 1 |
| Hubbs, A | 1 |
| Larsen, ST | 1 |
| Alarie, Y | 1 |
| Hammer, M | 1 |
| Nielsen, GD | 1 |
| Kovacic, P | 1 |
| Cooksy, AL | 1 |
| Kim, TJ | 2 |
| Materna, BL | 2 |
| Prudhomme, JC | 2 |
| Fedan, KB | 2 |
| Enright, PL | 3 |
| Sahakian, NM | 1 |
| Windham, GC | 1 |
| Mathews, JM | 1 |
| Watson, SL | 1 |
| Snyder, RW | 1 |
| Burgess, JP | 1 |
| Kirby, PJ | 1 |
| Foley, JF | 1 |
| Nasrullah, M | 1 |
| Potera, C | 1 |
| Gomaa, A | 1 |
| Kullman, G | 1 |
| Fedan, K | 1 |
| Simoes, EJ | 1 |
| Schachter, EN | 1 |
| Ezrailson, EG | 1 |
| Taubert, D | 1 |
| Lazar, A | 1 |
| Schömig, E | 1 |
| Parmet, AJ | 1 |
| Saechao, K | 1 |
| Boomus, C | 1 |
| Prokop, M | 1 |
| Moss, MH | 1 |
| Horton, MR | 1 |
| Modi, P | 1 |
| Yadava, V | 1 |
| Sreedhar, R | 1 |
| Khasawaneh, F | 1 |
| Balk, RA | 1 |
10 reviews available for diacetyl and Bronchiolitis, Exudative
| Article | Year |
|---|---|
Flavorings-Related Lung Disease: A Brief Review and New Mechanistic Data.
Topics: Acetoin; Air Pollutants, Occupational; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Humans; | 2019 |
[Advances in flavoring-related bronchiolitis obliterans].
Topics: Bronchiolitis Obliterans; China; Diacetyl; Flavoring Agents; Humans; Occupational Diseases; Occupati | 2020 |
Early detection, clinical diagnosis, and management of lung disease from exposure to diacetyl.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Humans; Inhalation Exposure; Lung Diseases; Oc | 2017 |
Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers.
Topics: Animals; Bronchiolitis Obliterans; Canada; Diacetyl; Disease Models, Animal; Evaluation Studies as T | 2014 |
Diacetyl exposure as a pneumotoxic factor: a review.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food-Processing Industry; Humans; Occupational | 2014 |
Popcorn lung and bronchiolitis obliterans: a critical appraisal.
Topics: Biopsy; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Humans; Inhalation Exposure; Lung; Occ | 2009 |
Food additives and sensitivities.
Topics: Anti-Bacterial Agents; Antioxidants; Aspartame; Bronchiolitis Obliterans; Coloring Agents; Cyclamate | 2009 |
Electron transfer as a potential cause of diacetyl toxicity in popcorn lung disease.
Topics: Bacteria; Bronchiolitis Obliterans; Diacetyl; Electron Transport; Ethanol; Humans; Reactive Oxygen S | 2010 |
Diacetyl-induced lung disease.
Topics: Animals; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Humans; Inhalation Exposure; Occupati | 2006 |
Flavoring-related bronchiolitis obliterans.
Topics: Bronchiolitis Obliterans; Butter; Diacetyl; Flavoring Agents; Humans; Occupational Diseases | 2007 |
40 other studies available for diacetyl and Bronchiolitis, Exudative
| Article | Year |
|---|---|
A Strategy for Field Evaluations of Exposures and Respiratory Health of Workers at Small- to Medium-Sized Coffee Facilities.
Topics: Bronchiolitis Obliterans; Coffee; Diacetyl; Food Industry; Humans; Occupational Exposure; United Sta | 2021 |
Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus.
Topics: Airway Remodeling; Animals; Bronchiolitis Obliterans; Diacetyl; Epithelial Cells; Humans; Influenza | 2022 |
[Two cases of airway dysfunction related to diacetyl exposure].
Topics: Bronchiolitis Obliterans; Diacetyl; Humans; Lung; Occupational Diseases; Occupational Exposure | 2023 |
Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.
Topics: Animals; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Proteasome Endopeptidase Complex; Rat | 2021 |
Case Report: Flavoring-Related Lung Disease in a Coffee Roasting and Packaging Facility Worker With Unique Lung Histopathology Compared With Previously Described Cases of Obliterative Bronchiolitis.
Topics: Adult; Bronchiolitis Obliterans; Coffee; Diacetyl; Humans; Lung; Lung Diseases; Male | 2021 |
Airway injury in an in vitro human epithelium-fibroblast model of diacetyl vapor exposure: diacetyl-induced basal/suprabasal spongiosis.
Topics: Bronchiolitis Obliterans; Cytokines; Diacetyl; Fibroblasts; Flavoring Agents; Humans; Inhalation Exp | 2017 |
Diacetyl and occupational bronchiolitis obliterans: Comments on Rose, CS: Early detection, clinical diagnosis and management of lung disease from exposure to diacetyl, toxicology (2017), https://doi.org/10.1016/j.tox.2017.03.019.
Topics: Bronchiolitis Obliterans; Diacetyl; Humans; Lung Diseases; Occupational Diseases; Occupational Expos | 2017 |
Pulmonary Impairment and Risk Assessment in a Diacetyl-Exposed Population: Microwave Popcorn Workers.
Topics: Adult; Air Pollutants, Occupational; Bronchiolitis Obliterans; Cross-Sectional Studies; Diacetyl; Fe | 2018 |
EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione.
Topics: Animals; Bronchiolitis Obliterans; Diacetyl; Epithelial Cells; ErbB Receptors; Extracellular Signal- | 2019 |
Upper and lower airways obstruction following an inhalation injury.
Topics: Airway Obstruction; Bronchiolitis Obliterans; Diacetyl; Humans; Inhalation Exposure; Occupational Ex | 2013 |
Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Bronchiolitis Obliterans; Cell Line; Diacetyl; Dose-Res | 2014 |
Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
Topics: Adult; Aged; Air Pollutants, Occupational; Bronchiolitis Obliterans; Cross-Sectional Studies; Diacet | 2014 |
Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases.
Topics: Adult; Airway Obstruction; Bronchiolitis Obliterans; Coffee; Cross-Sectional Studies; Diacetyl; Dysp | 2015 |
Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers.
Topics: Air Pollutants, Occupational; Bronchiolitis Obliterans; Coffee; Diacetyl; Dust; Flavoring Agents; Fo | 2016 |
Recognizing occupational effects of diacetyl: What can we learn from this history?
Topics: Animals; Bronchiolitis Obliterans; Cooperative Behavior; Diacetyl; Disease Models, Animal; Flavoring | 2017 |
Pathology of diacetyl and 2,3-pentanedione airway lesions in a rat model of obliterative bronchiolitis.
Topics: Animals; Basement Membrane; Bronchiolitis Obliterans; Diacetyl; Disease Models, Animal; Flavoring Ag | 2017 |
Diacetyl and bronchiolitis obliterans.
Topics: Air Pollutants, Occupational; Bronchiolitis Obliterans; Diacetyl; Food Industry; Humans; Occupationa | 2008 |
Diacetyl exposures in the flavor manufacturing industry.
Topics: Air Pollutants, Occupational; Air Pollution, Indoor; Bronchiolitis Obliterans; Butter; Diacetyl; Env | 2008 |
A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
Topics: Adult; Air Pollutants, Occupational; Bronchiolitis Obliterans; Chemical Industry; Cross-Sectional St | 2009 |
The popcorn lung case study: a recipe for regulation?
Topics: Air Pollutants, Occupational; Air Pollution, Indoor; Bronchiolitis Obliterans; Butter; Diacetyl; Fla | 2009 |
Response to Galbraith and Weill.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Humans; Inhalation Exposure; Lung | 2010 |
Letter to the editor: RE: Galbraith D and Weill D (2009), popcorn lung and bronchiolitis obliterans: a critical appraisal 82:407-416.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food Industry; Humans; Inhalation Exposure; Oc | 2010 |
Authors' response to Kreiss et al. (2009).
Topics: Biopsy; Bronchiolitis Obliterans; Diacetyl; Humans; Occupational Exposure; Tomography, X-Ray Compute | 2010 |
Acute airway effects of diacetyl in mice.
Topics: Animals; Bronchiolitis Obliterans; Diacetyl; Dose-Response Relationship, Drug; Inhalation Exposure; | 2009 |
Industry-wide medical surveillance of California flavor manufacturing workers: Cross-sectional results.
Topics: Adult; Bronchiolitis Obliterans; California; Cross-Sectional Studies; Diacetyl; Female; Flavoring Ag | 2010 |
Reaction of the butter flavorant diacetyl (2,3-butanedione) with N-α-acetylarginine: a model for epitope formation with pulmonary proteins in the etiology of obliterative bronchiolitis.
Topics: Arginine; Bronchiolitis Obliterans; Butter; Diacetyl; Flavoring Agents; Humans; Mass Spectrometry; M | 2010 |
Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.
Topics: Animals; Bronchiolitis Obliterans; Cell Proliferation; Diacetyl; Disease Progression; Epithelial Cel | 2011 |
Longitudinal lung function declines among California flavoring manufacturing workers.
Topics: Adolescent; Adult; Aged; Bronchiolitis Obliterans; California; Diacetyl; Female; Flavoring Agents; F | 2012 |
Still searching for better butter flavoring.
Topics: Animals; Bronchiolitis Obliterans; Butter; Diacetyl; Flavoring Agents; Humans; Inhalation Exposure; | 2012 |
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.
Topics: Adolescent; Adult; Aged; Bronchiolitis Obliterans; Chronic Disease; Diacetyl; Female; Flavoring Agen | 2002 |
Popcorn worker's lung.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food-Processing Industry; Humans; Occupational | 2002 |
Bronchiolitis in popcorn-factory workers.
Topics: Bronchiolitis Obliterans; Butylene Glycols; Diacetyl; Flavoring Agents; Food-Processing Industry; Hu | 2002 |
Bronchiolitis in popcorn-factory workers.
Topics: Air Pollutants, Occupational; Animals; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food-Pr | 2002 |
Bronchiolitis in popcorn-factory workers.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food-Processing Industry; Humans; Occupational | 2002 |
Fixed obstructive lung disease among workers in the flavor-manufacturing industry--California, 2004-2007.
Topics: Adult; Bronchiolitis Obliterans; California; Chemical Industry; Diacetyl; Female; Flavoring Agents; | 2007 |
Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings.
Topics: Adult; Aged; Air Pollutants, Occupational; Bronchiolitis Obliterans; Diacetyl; Female; Food Industry | 2007 |
Occupational bronchiolitis obliterans masquerading as COPD.
Topics: Air Pollutants, Occupational; Bronchiolitis Obliterans; Diacetyl; Diagnosis, Differential; Food Indu | 2007 |
Potential exposures to the chemical, diacetyl, in Connecticut workplaces.
Topics: Bronchiolitis Obliterans; Connecticut; Diacetyl; Humans; Occupational Diseases; Occupational Exposur | 2007 |
Respiratory CSI: diagnosing occupationally related lung disease.
Topics: Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food Industry; Humans; Medical History Taking; | 2008 |
A case of flavor-induced lung disease.
Topics: Adult; Bronchiolitis Obliterans; Diacetyl; Flavoring Agents; Food Industry; Humans; Male; Occupation | 2008 |