Page last updated: 2024-08-22

diacerein and Osteoarthritis

diacerein has been researched along with Osteoarthritis in 97 studies

Research

Studies (97)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (5.15)	18.7374
1990's	26 (26.80)	18.2507
2000's	31 (31.96)	29.6817
2010's	24 (24.74)	24.3611
2020's	11 (11.34)	2.80

Authors

Authors	Studies
Cao, S; He, S; Hu, B; Jiang, M; Wang, J; Wang, T; Wei, W; Yang, C; Ye, Y; Zhang, X; Zuo, J	1
Ali, A; Jabar, A; Jan, N; Khan, A; Khan, S; Madni, A; Rahim, MA; Shah, H	1
Jain, M; Joharapurkar, A; Patel, V	1
Alekseeva, LI; Amirdzhanova, VN; Filatova, ES; Karateev, AE; Lila, AM; Nesterenko, VA; Pogozheva, EY	1
Auddy, B; Chattopadhyay, H; Datta, S; Gupta, M; Sur, T	1
Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG	1
Abbas, AB; Al-Shaebi, F; Almezgagi, M; Gamah, M; Han, Y; Hezam, K; Jia, R; Saif, B; Shamsan, E; Shoaib, M; Zhang, W; Zhang, Y	1
Ahmad, NM; Ahmed, N; Haq, IU; Rehman, AU; Siddiqui, B	1
Ibrahim, HK; Nour, SAE; Soliman, MAN	1
Cavenaghi Pereira da Silva, M; Correa Maldonado, D; Faber, J; Kerkis, I; Martinez Saez, D; Nicoliche, T; Tetsuo Sasaki, R	1
Abdel-Aziem, SH; Abdel-Aziz, MA; Abdel-Wahhab, MA; Ahmed, HMS; El-Nekeety, AA; Sharaf, HA	1
Bao, L; Chan, LS; Many, B; Mohan, GC; Zhang, H	1
Alegría, A; Irarrázaval, S	1
Alegría Mejías, AI; Bravo Soto, G; Irarrázaval, S; Rada, G	1
Leeb, B	1
Kaltenegger, H; Kullich, W; Leithner, A; Lohberger, B; Mann, A; Steinecker-Frohnwieser, B; Stuendl, N; Weigl, L	1
Kim, JW; Lee, EB; Lee, EY; Moon, KW; Shin, K; Song, YW; Yang, JA	1
Abhay, H; Dhaneshwar, S; Dipmala, P; Prashant, B	1
Jain, A; Singh, S; Singh, SK; Singh, Y	1
Jain, A; Mishra, SK; Singh, R; Singh, S; Singh, SK; Vuddanda, PR	1
Fernandes Moça Trevisani, V; Fidelix, TS; Macedo, CR; Maxwell, LJ	1
Kullich, W; Lohberger, B; Steinecker-Frohnwieser, B; Weigl, L	1
Jones, G; Panova, E	1
Dhaneshwar, S; Kadam, P; Patil, D	1
Li, G; Li, Y; Li, Z; Meng, D; Tian, K; Xu, J	1
Starodubtseva, IA; Tsvetikova, LN	1
Abd-Allah, FI; El-Say, KM; Hassan, Ael-S; Kassem, AE; Lila, AE	1
Caeiro, JR; González-Cantalapiedra, A; Guede, D; López-Peña, M; Muñoz, F; Permuy, M	2
Bruyère, O; Cooper, C; Kanis, JA; Leeb, BF; Maheu, E; Martel-Pelletier, J; Monfort, J; Pavelka, K; Pelletier, JP; Reginster, JY; Rizzoli, R	1
Nikitin, AV; Starodubtseva, IA; Vasilieva, LV	1
Budprom, P; Chokchaitaweesuk, C; Chomdej, S; Kongdang, P; Nganvongpanit, K; Ongchai, S; Ruangsuriya, J; Sirikaew, N; Viriyakhasem, N	1
Boileau, C; Cheng, S; Martel-Pelletier, J; Pelletier, JP; Tat, SK	1
Bay-Jensen, AC; Christiansen, C; Dam, EB; Karsdal, MA; Pastoureau, P; Qvist, P	1
de Isla, NG; Stoltz, JF	1
Fleck, M; Härle, P	1
Bruyère, O; Burlet, N; Cooper, C; Delmas, PD; Reginster, JY; Rizzoli, R	1
Charif, N; de Isla, N; Stoltz, JF	1
Richette, P	1
Dhaneshwar, S; Patil, D	1
Camardella, L; Cancedda, R; Dozin, B; Malpeli, M; Pietrangelo, A	1
Colville-Nash, PR	1
Cohen, P; Provvedini, D	1
Bruyere, O; Henrotin, Y; Reginster, JY	1
Abadie, E; Avouac, B; Bouvenot, G; Branco, J; Bruyere, O; Calvo, G; Devogelaer, JP; Dreiser, RL; Ethgen, D; Herrero-Beaumont, G; Kahan, A; Kreutz, G; Laslop, A; Lemmel, EM; Nuki, G; Reginster, JY; Van De Putte, L; Vanhaelst, L	1
Reginster, JY	1
Solignac, M	1
Baker, CL; Ferguson, CM	1
Mulero Mendoza, J	1
Dieppe, P	1
Balligand, M; Henrotin, Y; Sanchez, C	1
Fidelix, TS; Soares, BG; Trevisani, VF	1
Clayton, JJ	1
Martel-Pelletier, J; Pelletier, JP	1
Giner-Ruiz, V; Reig-Mollá, B; Sanfélix-Genovés, J; Sanfélix-Gimeno, G	2
Gabor, F; Goldring, MB; Piana, C; Toegel, S; Unger, FM; Viernstein, H; Wirth, M; Wu, SQ	1
de Isla, NG; Mainard, D; Muller, S; Stoltz, JF	1
Grahame, R; Griffiths, LG; Kay, AG; Volans, GN	1
Berdah, L; Mazières, B; Thiéchart, M; Viguier, G	1
Berdah, L; Taccoen, A	1
Cruz, TF; Pronost, S; Pujol, JP; Tang, J	1
Bendele, AM; Bendele, RA; Hulman, JF; Swann, BP	1
Delcambre, B; Taccoen, A	1
Blanckaert, A; Mazières, B; Thiéchart, M; Viguier, G	1
Valat, JP	2
Brun, PH	1
Shirazi, I; Yaron, I; Yaron, M	2
Alam, CA; Greenslade, KJ; Moore, AR; Willoughby, DA	2
Albrecht, M; Brandt, KD; Kang, SY; Myers, S; O'Connor, B; Smith, G	2
Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Mineau, F; Pelletier, JP	1
Bouvenot, G; Villani, P	1
Nicolas, P; Padoin, C; Petitjean, O; Tod, M	1
Duval, N; Fernandes, JC; Martel-Pelletier, J; Mineau, F; Pelletier, JP	1
Albrecht, ME; Brandt, KD; Mickler, EA; Myers, SL; Smith, GN	1
Bardin, T; Berdah, L; Bono, I; Bouvenot, G; Dreiser, RL; Eschwege, E; Fagnani, F; Lafuma, A; Valat, JP	1
Bogdanowicz, P; Boumediene, K; Felisaz, N; Galerra, P; Ghayor, C; Herrouin, JF; Pujol, JP	1
Cloutier, JM; Jolicoeur, FC; Martel-Pelletier, J; Moldovan, F; Pelletier, JP	1
Carney, SL	1
Ishiwa, J; Ito, A; Kosaka, N; Nagase, H; Sato, T; Tamura, T	1
Lequesne, M; Samson, M	1
Fernandes, JC; Lajeunesse, D; Martel-Pelletier, J; Mineau, F; Pelletier, JP; Reboul, P; Sabouret, P	1
Burkhardt, D; Ghosh, P; Hwa, SY; Little, C	1
Henrotin, Y; Reginster, JY	1
Dougados, M; Falgarone, G	1
Polisson, R	1
Bogliolo, A; Loi, A; Perpignano, G	1
Borella, F; Caldini, R; Colombo, F; Del Rosso, M; Dini, G; Fibbi, G; Grappone, C; Magnelli, L; Pucci, M; Serni, U	1
Bocchieri, E; Mazzaro, C; Romagnoli, A; Tesolin, GF; Ventre, L	1
Cervini, C; Grassi, W	1
Angelini, M; Carrabba, M; Chevallard, M; Mele, G	1
Adami, S; Bortolotti, R; Guarrera, G; Lo Cascio, V; Marini, G; Rosini, S; Zampieri, A	1

Reviews

28 review(s) available for diacerein and Osteoarthritis

Article	Year
Therapeutic Potential of Diacerein in Management of Pain. Current drug research reviews, 2022, Volume: 14, Issue:3 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cytokines; Glutamates; Histamine; Humans; Matrix Metalloproteinases; Nitric Oxide; Osteoarthritis; Pain; Prostaglandins; Substance P; Transient Receptor Potential Channels	2022
Diacerein: Recent insight into pharmacological activities and molecular pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Diabetes Mellitus; Gastrointestinal Diseases; Humans; Inflammation Mediators; Kidney Diseases; Osteoarthritis; Signal Transduction	2020
Is diacerein an alternative for the treatment of osteoarthritis? Medwave, 2017, 10-12, Volume: 17, Issue:8 Topics: Anthraquinones; Anti-Inflammatory Agents; Diarrhea; Humans; Osteoarthritis	2017
Diacerein for osteoarthritis. The Cochrane database of systematic reviews, 2014, Feb-10, Issue:2 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Randomized Controlled Trials as Topic	2014
Benefit-risk assessment of diacerein in the treatment of osteoarthritis. Drug safety, 2015, Volume: 38, Issue:3 Topics: Anthraquinones; Anti-Inflammatory Agents; Diarrhea; Humans; Osteoarthritis; Radiography; Risk Assessment; Treatment Outcome	2015
Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. Drugs & aging, 2016, Volume: 33, Issue:2 Topics: Anthraquinones; Anti-Inflammatory Agents; Bone Remodeling; Delayed-Action Preparations; Humans; Osteoarthritis; Pharmacovigilance; Risk Assessment	2016
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon? Pharmacological research, 2008, Volume: 58, Issue:1 Topics: Anthraquinones; Antirheumatic Agents; Calcitonin; Cytokines; Diphosphonates; Doxycycline; Glucosamine; Humans; Matrix Metalloproteinase Inhibitors; Nitric Oxide Synthase Type II; Osteoarthritis	2008
[Treatment of osteoarthritis with drugs and other modalities]. Der Internist, 2008, Volume: 49, Issue:12 Topics: Administration, Oral; Anthraquinones; Anti-Inflammatory Agents; Chondroitin Sulfates; Combined Modality Therapy; Complementary Therapies; Glucosamine; Humans; Hyaluronic Acid; Injections, Intra-Articular; Joint Prosthesis; Osteoarthritis; Treatment Outcome	2008
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. BMC musculoskeletal disorders, 2008, Dec-16, Volume: 9 Topics: Anthraquinones; Antirheumatic Agents; Calcitonin; Chondroitin Sulfates; Clinical Trials as Topic; Etidronic Acid; Glucosamine; Humans; Hyaluronic Acid; Organometallic Compounds; Osteoarthritis; Outcome Assessment, Health Care; Plant Extracts; Risedronic Acid; Thiophenes	2008
[Management of osteoarthritis: oral therapies]. La Revue du praticien, 2012, Volume: 62, Issue:5 Topics: Administration, Oral; Analgesics; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chondroitin Sulfates; Doxycycline; Humans; Osteoarthritis; Treatment Outcome	2012
[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis]. Presse medicale (Paris, France : 1983), 2002, Dec-07, Volume: 31, Issue:39 Pt 2 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Disease Progression; Humans; Interleukin-1; Osteoarthritis; Radiography; Treatment Outcome	2002
New perspectives in the management of osteoarthritis. structure modification: facts or fantasy? The Journal of rheumatology. Supplement, 2003, Volume: 67 Topics: Anthraquinones; Anti-Inflammatory Agents; Chondroitin Sulfates; Glucosamine; Humans; Nonprescription Drugs; Osteoarthritis; Plant Oils	2003
Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis. Osteoarthritis and cartilage, 2004, Volume: 12, Issue:4 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cartilage, Articular; Disease Progression; Glucosamine; Humans; Interleukin-1; Joints; Magnetic Resonance Imaging; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Practice Guidelines as Topic; Radiography; Treatment Outcome	2004
[Chondromodulation in 2003: dream or reality?]. Revue medicale de la Suisse romande, 2004, Volume: 124, Issue:2 Topics: Anthraquinones; Chondrocytes; Chondroitin Sulfates; Glucosamine; Humans; Osteoarthritis; Plant Extracts	2004
[Mechanisms of action of diacerein, the first inhibitor of interleukin-1 in osteoarthritis]. Presse medicale (Paris, France : 1983), 2004, May-22, Volume: 33, Issue:9 Pt 2 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Humans; Hyaluronic Acid; Interleukin-1; Osteoarthritis; Proteoglycans; Randomized Controlled Trials as Topic; Transforming Growth Factors; Treatment Outcome	2004
Future treatment of osteoarthritis. Orthopedics, 2005, Volume: 28, Issue:2 Suppl Topics: Adjuvants, Immunologic; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Camellia sinensis; Cartilage, Articular; Chondrocytes; Chondroitin; Forecasting; Genetic Therapy; Glucosamine; Humans; Hyaluronic Acid; Osteoarthritis; Phytotherapy; Plant Extracts	2005
Pharmaceutical and nutraceutical management of canine osteoarthritis: present and future perspectives. Veterinary journal (London, England : 1997), 2005, Volume: 170, Issue:1 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Glycine max; Osteoarthritis; Persea; Phytotherapy	2005
Diacerein for osteoarthritis. The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; Randomized Controlled Trials as Topic	2006
Nutraceuticals in the management of osteoarthritis. Orthopedics, 2007, Volume: 30, Issue:8 Topics: Aged; Amino Acids, Sulfur; Anthraquinones; Boswellia; Chondroitin; Dietary Supplements; Gelatin; Glucosamine; Humans; Hydroxyproline; Osteoarthritis; Persea; Phytotherapy; Plant Oils; Protein Hydrolysates; S-Adenosylmethionine; Soybean Oil	2007
DMOAD developments: present and future. Bulletin of the NYU hospital for joint diseases, 2007, Volume: 65, Issue:3 Topics: Acetates; Anthraquinones; Antirheumatic Agents; Chondroitin; Clinical Trials as Topic; Diphosphonates; Disease Progression; Doxycycline; Glucosamine; Humans; Hyaluronic Acid; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrroles; Risk Factors	2007
[Review of the evidence about drugs used as SYSADOA]. Medicina clinica, 2007, Nov-03, Volume: 129, Issue:16 Topics: Administration, Oral; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chondroitin Sulfates; Clinical Trials as Topic; Delayed-Action Preparations; Drug Evaluation; Evidence-Based Medicine; Glucosamine; Humans; Hyaluronic Acid; Injections, Intra-Articular; Meta-Analysis as Topic; Osteoarthritis	2007
In vitro effects of diacerein on NO production by chondrocytes in response to proinflammatory mediators. Bio-medical materials and engineering, 2008, Volume: 18, Issue:1 Suppl Topics: Anthraquinones; Anti-Inflammatory Agents; Cells, Cultured; Chondrocytes; Humans; Immunologic Factors; Interleukin-1beta; Nitric Oxide; Osteoarthritis	2008
[Effectiveness of drugs used in degenerative joint diseases (arthroses)]. Medicina clinica, 2008, Apr-05, Volume: 130, Issue:12 Topics: Anthraquinones; Anti-Inflammatory Agents; Chondroitin Sulfates; Glucosamine; Hyaluronic Acid; Joints; Osteoarthritis; Treatment Outcome	2008
[Assessment of the placebo effect of symptomatic slow-acting anti-arthritics]. Presse medicale (Paris, France : 1983), 1998, Feb-07, Volume: 27, Issue:5 Topics: Activities of Daily Living; Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Chondroitin Sulfates; Female; Humans; Hydroxyproline; Male; Middle Aged; Osteoarthritis; Pain; Pain Measurement; Placebo Effect; Randomized Controlled Trials as Topic; Research Design; Time Factors; Treatment Outcome	1998
Clinical pharmacokinetics of diacerein. Clinical pharmacokinetics, 1998, Volume: 35, Issue:5 Topics: Aged; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Drug Interactions; Food-Drug Interactions; Humans; Kidney Diseases; Liver Diseases; Osteoarthritis; Time Factors	1998
Diacerein as a disease-modulating agent in osteoarthritis. Current rheumatology reports, 2001, Volume: 3, Issue:6 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Humans; Osteoarthritis	2001
Innovative therapies in osteoarthritis. Current rheumatology reports, 2001, Volume: 3, Issue:6 Topics: Acupuncture; Analgesics; Analgesics, Opioid; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cartilage, Articular; Cyclooxygenase Inhibitors; Female; Genetic Therapy; Growth Substances; Hormone Replacement Therapy; Humans; Male; Osteoarthritis; Tetracyclines	2001
[Drug therapy of arthrosis]. La Clinica terapeutica, 1987, Dec-31, Volume: 123, Issue:6 Topics: Adrenal Cortex Hormones; Aged; Analgesics; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Diuretics; Drug Therapy, Combination; Glycosaminoglycans; Humans; Indomethacin; Osteoarthritis; Rabbits; Superoxide Dismutase	1987

Trials

9 trial(s) available for diacerein and Osteoarthritis

Article	Year
The efficacy of diacerein in hand osteoarthritis: a double-blind, randomized, placebo-controlled study. Clinical therapeutics, 2013, Volume: 35, Issue:4 Topics: Anthraquinones; Anti-Inflammatory Agents; Double-Blind Method; Hand; Humans; Osteoarthritis; Placebos	2013
[The pathogenetic substantiation of new therapeutic approach to the treatment of secondary osteoarthritis in patients with rheumatoid arthritis with basis therapy]. Advances in gerontology = Uspekhi gerontologii, 2014, Volume: 27, Issue:3 Topics: Aged; Anthraquinones; Arthritis, Rheumatoid; Cartilage Oligomeric Matrix Protein; Combined Modality Therapy; Female; Humans; Interleukin-1; Low-Level Light Therapy; Male; Middle Aged; Osteoarthritis; Treatment Outcome	2014
Preliminary experience with diacetylrhein in the treatment of osteoarthritis. Current medical research and opinion, 1980, Volume: 6, Issue:8 Topics: Aged; Anthraquinones; Female; Humans; Male; Middle Aged; Osteoarthritis; Radiography; Recurrence	1980
[Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit]. Revue du rhumatisme (Ed. francaise : 1993), 1993, Volume: 60, Issue:6 Pt 2 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Disease Models, Animal; Female; Knee Injuries; Osteoarthritis; Rabbits	1993
[Study of ART 50 in daily rheumatological practice]. La Revue du praticien, 1996, Mar-15, Volume: 46, Issue:6 Spec No Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Drug Tolerance; Female; Humans; Male; Middle Aged; Osteoarthritis	1996
[Pragmatic study of diacerhein: results on clinical signs, quality of life and medico-economic costs]. La Revue du praticien, 1997, Volume: 47, Issue:17 Suppl Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Drug Evaluation; Female; Health Care Costs; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Osteoarthritis, Hip; Quality of Life	1997
[Functional manifestations of osteoarthritis: key points to the clinical efficacy of diacerhein]. Presse medicale (Paris, France : 1983), 1998, Sep-05, Volume: 27, Issue:25 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; France; Humans; Middle Aged; Osteoarthritis	1998
Medico-economic analysis of diacerein with or without standard therapy in the treatment of osteoarthritis. PharmacoEconomics, 1998, Volume: 13, Issue:1 Pt 2 Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Diarrhea; Double-Blind Method; Female; France; Humans; Male; Middle Aged; Osteoarthritis; Prospective Studies; Quality of Life	1998
[Diacereine: an original approach in the treatment of degenerative and/or extra-articular rheumatism]. Minerva medica, 1987, Feb-15, Volume: 78, Issue:3 Topics: Administration, Oral; Adult; Aged; Anthraquinones; Clinical Trials as Topic; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Osteoarthritis	1987

Other Studies

60 other study(ies) available for diacerein and Osteoarthritis

Article	Year
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment. Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Bone and Bones; Cartilage, Articular; Cell Differentiation; Iodoacetic Acid; Lipopolysaccharides; Macrophage Colony-Stimulating Factor; Male; Mice; Osteoarthritis; Osteoclasts; Pentacyclic Triterpenes; Pyrazoles; RANK Ligand; Rats, Sprague-Dawley; RAW 264.7 Cells	2021
Fabrication, in vitro and ex vivo evaluation of proliposomes and liposomal derived gel for enhanced solubility and permeability of diacerein. PloS one, 2021, Volume: 16, Issue:10 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Drug Carriers; Drug Liberation; Gels; Liposomes; Osteoarthritis; Permeability; Rats; Rats, Wistar	2021
[Efficacy of combined use of glycosaminoglycan peptide complex for intramuscular administration and oral diacerein in osteoarthritis: evaluation according to an observational multicenter clinical trial]. Terapevticheskii arkhiv, 2021, May-15, Volume: 93, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Glycosaminoglycans; Humans; Middle Aged; Osteoarthritis; Osteoarthritis, Knee; Pain; Peptides; Retrospective Studies; Treatment Outcome	2021
Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis. Drug delivery and translational research, 2020, Volume: 10, Issue:5 Topics: Administration, Cutaneous; Animals; Anthraquinones; Emulsions; Glucosamine; Osteoarthritis; Rats; Skin; Skin Absorption	2020
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. International journal of pharmaceutics, 2020, May-15, Volume: 581 Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Diarrhea; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Humans; Injections, Intra-Articular; Iodoacetic Acid; Male; Nanoparticles; Osteoarthritis; Pilot Projects; Polylactic Acid-Polyglycolic Acid Copolymer; Primary Cell Culture; Rats; Synoviocytes; X-Ray Microtomography	2020
Development, optimisation, and evaluation of nanoencapsulated diacerein emulgel for potential use in osteoarthritis. Journal of microencapsulation, 2020, Volume: 37, Issue:8 Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Biomimetics; Chitosan; Drug Delivery Systems; Drug Design; Gels; In Vitro Techniques; Male; Nanoparticles; Osteoarthritis; Particle Size; Polymers; Rats; Rats, Sprague-Dawley; Skin; Spectroscopy, Fourier Transform Infrared; Viscosity	2020
Diacerein solid dispersion loaded tablets for minimization of drug adverse effects: statistical design, formulation, Pharmaceutical development and technology, 2021, Volume: 26, Issue:3 Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Drug Liberation; Humans; Male; Osteoarthritis; Rabbits; Solubility; Tablets	2021
Intra-articular human deciduous dental pulp stem cell administration vs. pharmacological therapy in experimental osteoarthritis rat model. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:9 Topics: Animals; Anthraquinones; Chondroitin; Dental Pulp; Disease Models, Animal; Dose-Response Relationship, Drug; Glucosamine; Humans; Injections, Intra-Articular; Male; Mesenchymal Stem Cells; Osteoarthritis; Rats; Rats, Wistar	2021
Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein Inflammopharmacology, 2021, Volume: 29, Issue:3 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Chenopodium; Disease Models, Animal; Drug Therapy, Combination; Female; Gold; Iodoacetic Acid; Metal Nanoparticles; Osteoarthritis; Plant Extracts; Rats; Rats, Sprague-Dawley; Treatment Outcome	2021
Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells. PloS one, 2017, Volume: 12, Issue:3 Topics: Anthraquinones; Anti-Inflammatory Agents; Atherosclerosis; Cells, Cultured; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-1alpha; Interleukin-1beta; Keratinocytes; Oligonucleotide Array Sequence Analysis; Osteoarthritis; Psoriasis; Real-Time Polymerase Chain Reaction	2017
Diacerein and arthrosis treatment. Medwave, 2018, 04-13, Volume: 18, Issue:2 Topics: Anthraquinones; Anti-Inflammatory Agents; Humans; Osteoarthritis; Practice Guidelines as Topic	2018
Comments on Alegría and Irarrázaval (2017): Is diacerein an alternative for the treatment of osteoarthritis? Medwave, 2018, Apr-12, Volume: 18, Issue:2 Topics: Anthraquinones; Humans; Osteoarthritis	2018
Mechanical exposure and diacerein treatment modulates integrin-FAK-MAPKs mechanotransduction in human osteoarthritis chondrocytes. Cellular signalling, 2019, Volume: 56 Topics: ADAMTS Proteins; Anthraquinones; Anti-Inflammatory Agents; Cell Line; Chondrocytes; Endopeptidases; Focal Adhesion Kinase 1; Humans; Interleukin-6; Ion Channels; Matrix Metalloproteinases; Mechanotransduction, Cellular; Osteoarthritis; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical; Stress, Physiological; Thiolester Hydrolases	2019
Disease-modifying effect of anthraquinone prodrug with boswellic acid on collagenase-induced osteoarthritis in Wistar rats. Inflammation & allergy drug targets, 2013, Volume: 12, Issue:4 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Anti-Ulcer Agents; Body Weight; Collagenases; Edema; Male; Osteoarthritis; Prodrugs; Rats; Rats, Wistar; Triterpenes	2013
Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects. Journal of biomedical nanotechnology, 2013, Volume: 9, Issue:5 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Biological Availability; Diarrhea; Drug Delivery Systems; Female; Lipids; Male; Nanoparticles; Osteoarthritis; Rats; Up-Regulation	2013
Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats. Nanomedicine : nanotechnology, biology, and medicine, 2014, Volume: 10, Issue:5 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chondroitin Sulfates; Drug Carriers; Female; Lipids; Male; Nanoparticles; Osteoarthritis; Rats	2014
The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli. Osteoarthritis and cartilage, 2014, Volume: 22, Issue:7 Topics: Anthraquinones; Antirheumatic Agents; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Chondrocytes; Collagen Type I; Fibronectins; Glycosaminoglycans; Humans; Inflammation; Interleukin-1beta; Interleukin-8; Matrix Metalloproteinase 1; Osteoarthritis; Physical Stimulation; Stress, Mechanical	2014
Diacerein-thymol prodrug: in vivo release and pharmacological screening in experimental models of osteoarthritis in Wistar rats. Inflammation & allergy drug targets, 2015, Volume: 13, Issue:6 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Collagenases; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Iodoacetates; Joints; Male; Motor Activity; Osteoarthritis; Pain Measurement; Prodrugs; Rats; Rats, Wistar; Stomach Ulcer; Thymol	2015
Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways. Inflammation, 2015, Volume: 38, Issue:4 Topics: Animals; Anthraquinones; Celecoxib; Drug Therapy, Combination; Male; MAP Kinase Signaling System; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Treatment Outcome	2015
Diacerein niosomal gel for topical delivery: development, in vitro and in vivo assessment. Journal of liposome research, 2016, Volume: 26, Issue:1 Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Delivery Systems; Edema; Gels; Liposomes; Male; Osteoarthritis; Rats	2016
Comparison of various SYSADOA for the osteoarthritis treatment: an experimental study in rabbits. BMC musculoskeletal disorders, 2015, May-20, Volume: 16 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Arthrography; Bone Density Conservation Agents; Cartilage, Articular; Chondroitin Sulfates; Disease Models, Animal; Drug Therapy, Combination; Female; Femur; Glucosamine; Hyaluronic Acid; Joints; Osteoarthritis; Rabbits; Risedronic Acid; Synovial Membrane; Tomography, X-Ray Computed	2015
Effects of diacerein on cartilage and subchondral bone in early stages of osteoarthritis in a rabbit model. BMC veterinary research, 2015, Jul-02, Volume: 11 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Female; Osteoarthritis; Rabbits	2015
[Correction of an inflammatory process with an interleukin-1 inhibitor in the combination treatment of secondary osteoarthritis in the presence of comorbid condition]. Terapevticheskii arkhiv, 2015, Volume: 87, Issue:12 Topics: Adult; Aged; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cartilage Oligomeric Matrix Protein; Combined Modality Therapy; Comorbidity; Female; Humans; Interleukin-1; Low-Level Light Therapy; Male; Methotrexate; Middle Aged; Osteoarthritis; Outcome Assessment, Health Care; Severity of Illness Index	2015
Suppression of Cartilage Degradation by Zingerone Involving the p38 and JNK MAPK Signaling Pathway. Planta medica, 2017, Volume: 83, Issue:3-04 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Cartilage; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycosaminoglycans; Guaiacol; Humans; Interleukins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Metacarpophalangeal Joint; Mitogen-Activated Protein Kinases; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; RNA, Messenger; Swine; Tumor Necrosis Factor-alpha	2017
Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. Arthritis research & therapy, 2008, Volume: 10, Issue:3 Topics: Aged; Aged, 80 and over; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone Remodeling; Cartilage, Articular; Cell Differentiation; Cell Line; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Female; Humans; Male; Mice; Osteoarthritis; Osteoclasts	2008
In vitro inhibition of IL-1beta catabolic effects on cartilage: a mechanism involved on diacerein anti-OA properties. Biorheology, 2008, Volume: 45, Issue:3-4 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Apoptosis; Cartilage; Cartilage, Articular; Cells, Cultured; Chondrocytes; Glycosaminoglycans; Interleukin-1beta; Nitric Oxide; Osteoarthritis; Rats; Synovial Membrane; Tumor Necrosis Factor-alpha	2008
Are FoxO transcription factors implicated in osteoarthritis? Influence of Diacerhein. Bio-medical materials and engineering, 2010, Volume: 20, Issue:3 Topics: Animals; Anthraquinones; Cartilage, Articular; Forkhead Transcription Factors; Humans; Models, Biological; Osteoarthritis	2010
Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia. Medicinal chemistry (Shariqah (United Arab Emirates)), 2013, Volume: 9, Issue:3 Topics: Animals; Anthraquinones; Chondrocytes; Disease Models, Animal; Hyperalgesia; Iodoacetic Acid; Osteoarthritis; Prodrugs; Rats	2013
Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects. Matrix biology : journal of the International Society for Matrix Biology, 2002, Volume: 21, Issue:5 Topics: Adult; Aged; Aging; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cell Division; Cells, Cultured; Chitinases; Chondrocytes; Female; Gene Expression; Humans; Interleukin-1; Male; Metalloendopeptidases; Middle Aged; Nitric Oxide; Osteoarthritis; Phenotype; Proteins; Tumor Necrosis Factor-alpha	2002
[Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model]. Presse medicale (Paris, France : 1983), 2002, Dec-07, Volume: 31, Issue:39 Pt 2 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Isoenzymes; Membrane Proteins; Mice; Osteoarthritis; Prostaglandin-Endoperoxide Synthases	2002
[Pharmacological treatment of osteoarthritis. Expectations and reality]. Revista clinica espanola, 2005, Volume: 205, Issue:4 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfates; Glucosamine; Humans; Osteoarthritis	2005
Disease modification in osteoarthritis: are drugs the answer? Arthritis and rheumatism, 2005, Volume: 52, Issue:7 Topics: Animals; Anthraquinones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Cartilage, Articular; Collagenases; Disease Models, Animal; Doxycycline; Enzyme Precursors; Humans; Osteoarthritis	2005
Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes. Osteoarthritis and cartilage, 2008, Volume: 16, Issue:10 Topics: Anthraquinones; Cell Proliferation; Cells, Cultured; Chondrocytes; Curcumin; Gene Expression; Glucosamine; Humans; Interleukin-1beta; Models, Biological; Osteoarthritis; Polymerase Chain Reaction; Protective Agents	2008
[Diacetylrhein, a new therapeutic approach of osteoarthritis]. Revue du rhumatisme (Ed. francaise : 1993), 1993, Volume: 60, Issue:6 Pt 2 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Humans; Interleukin-1; Osteoarthritis; Treatment Outcome	1993
[Molecular mechanisms implicated in the inhibition of collagenase expression by diacerheine]. La Revue du praticien, 1996, Mar-15, Volume: 46, Issue:6 Spec No Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Collagenases; Interleukin-1; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1	1996
[Beneficial effects of treatment with diacerhein in guinea pigs with osteoarthritis]. La Revue du praticien, 1996, Mar-15, Volume: 46, Issue:6 Spec No Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Knee Joint; Male; Osteoarthritis; Patella	1996
[Diacetylrhein administrated "curatively" in an experimental model of post-contusion osteoarthritis in rabbits]. La Revue du praticien, 1996, Dec-01, Volume: 46, Issue:19 Spec No Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Collagenases; Contusions; Disease Models, Animal; Osteoarthritis; Rabbits	1996
[Why pragmatic trials of the treatment of osteoarthritis? Application to the pragmatic study of diacetylrhein]. La Revue du praticien, 1996, Dec-01, Volume: 46, Issue:19 Spec No Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Evaluation; Humans; Osteoarthritis	1996
Effect of diacetylrhein on the development of experimental osteoarthritis. A biochemical investigation. Osteoarthritis and cartilage, 1997, Volume: 5, Issue:4 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Osteoarthritis	1997
[Anti-interleukin-1 effects of diacerhein in vitro]. La Revue du praticien, 1997, Volume: 47, Issue:17 Suppl Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Culture Techniques; Humans; Interleukin-1; Lipopolysaccharides; NADH, NADPH Oxidoreductases; Osteoarthritis; Proteoglycans; Synovial Membrane	1997
[Effects of diacerhein on cytokine determinations in a model of cartilage degradation induced by granuloma in mice]. La Revue du praticien, 1997, Volume: 47, Issue:17 Suppl Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cytokines; Disease Models, Animal; Glycosaminoglycans; Granuloma; Hydroxyproline; Mice; Mice, Transgenic; Osteoarthritis	1997
[Effects of diacerhein on canine model with accelerated osteoarthritis]. La Revue du praticien, 1997, Volume: 47, Issue:17 Suppl Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Disease Models, Animal; Dogs; Osteoarthritis; Proteoglycans	1997
Effects of diacerhein in an accelerated canine model of osteoarthritis. Osteoarthritis and cartilage, 1997, Volume: 5, Issue:6 Topics: Animals; Anterior Cruciate Ligament Injuries; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage Diseases; Cartilage, Articular; Collagenases; Disease Models, Animal; Dogs; Exudates and Transudates; Knee Joint; Male; Metalloendopeptidases; Osteoarthritis; Proteoglycans; Synovial Fluid; Synovial Membrane; Ulcer	1997
In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes. The Journal of rheumatology, 1998, Volume: 25, Issue:4 Topics: Aged; Anthraquinones; Blotting, Northern; Cells, Cultured; Chondrocytes; Culture Techniques; Enzyme Inhibitors; Female; Humans; Interleukin-1; Lipopolysaccharides; Male; Matrix Metalloproteinase 3; Middle Aged; Osteoarthritis; Receptors, Interleukin-1; Receptors, Tumor Necrosis Factor; Synovial Membrane; Tumor Necrosis Factor-alpha	1998
Effects of diacerhein on granuloma induced cartilage breakdown in the mouse. Osteoarthritis and cartilage, 1998, Volume: 6, Issue:1 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Cytokines; Diclofenac; Dose-Response Relationship, Drug; Glycosaminoglycans; Granuloma; Hydroxyproline; Male; Mice; Osteoarthritis; Rats; Rats, Wistar	1998
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. The Journal of rheumatology, 1998, Volume: 25, Issue:12 Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases	1998
Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. Arthritis and rheumatism, 1999, Volume: 42, Issue:3 Topics: Animals; Anterior Cruciate Ligament; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Cartilage, Articular; Collagenases; Disease Models, Animal; Dogs; Femur; Joint Instability; Knee Joint; Organ Culture Techniques; Osteoarthritis; Proteoglycans; Synovial Fluid; Synovial Membrane	1999
Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1. Osteoarthritis and cartilage, 1999, Volume: 7, Issue:3 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cattle; Chondrocytes; Drug Evaluation, Preclinical; Luciferases; Osteoarthritis; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Transforming Growth Factor beta	1999
Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures. Osteoarthritis and cartilage, 1999, Volume: 7, Issue:3 Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Female; Humans; Interleukin-1; Male; Nitric Oxide; Osteoarthritis; Receptors, Interleukin-1	1999
Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage. Osteoarthritis and cartilage, 2000, Volume: 8, Issue:3 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Northern; Cartilage, Articular; Caspase 1; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Situ Hybridization; Interleukin-1; Interleukin-18; Male; Osteoarthritis; RNA, Messenger	2000
Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation. Osteoarthritis and cartilage, 1996, Volume: 4, Issue:4 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cartilage, Articular; Cells, Cultured; Chondroitin Sulfates; Disease Models, Animal; Dogs; Epitopes; Glycosaminoglycans; Hydroxyproline; Osteoarthritis; Proteoglycans	1996
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis and cartilage, 2001, Volume: 9, Issue:3 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chondrocytes; Down-Regulation; Enzyme Inhibitors; Hindlimb; Joints; Matrix Metalloproteinases; Osteoarthritis; Protease Inhibitors; Rabbits; Tissue Inhibitor of Metalloproteinases	2001
Reports of equivalence trials should not mask negative or mediocre results. Joint bone spine, 2001, Volume: 68, Issue:2 Topics: Analgesics; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Glycosides; Humans; Osteoarthritis; Pyrans; Therapeutic Equivalency	2001
Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone. The Journal of rheumatology, 2001, Volume: 28, Issue:4 Topics: Aged; Aged, 80 and over; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Bone Remodeling; Cells, Cultured; Female; Humans; Male; Middle Aged; Osteoarthritis; Osteoblasts	2001
The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. The Journal of rheumatology, 2001, Volume: 28, Issue:4 Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Bone and Bones; Bone Density; Cartilage, Articular; Female; Osteoarthritis; Sheep	2001
[Pharmacy clinics. How I treat...Osteoarthritis. 2nd part: new therapeutic perspectives]. Revue medicale de Liege, 2001, Volume: 56, Issue:3 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondroitin; Disease Progression; Glucosamine; Humans; Hyaluronic Acid; Osteoarthritis	2001
[Fangotherapy and diacerein in the treatment of osteoarthrosis of the hip and knee]. La Clinica terapeutica, 1991, Apr-15, Volume: 137, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Knee Joint; Male; Middle Aged; Mud Therapy; Osteoarthritis; Osteoarthritis, Hip; Time Factors	1991
Modulation of urokinase receptors on human synovial cells and osteoarthritic chondrocytes by diacetylrhein. International journal of tissue reactions, 1990, Volume: 12, Issue:2 Topics: Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Fibrinolysis; Gold; Humans; Iodine Radioisotopes; Microscopy, Electron; Osteoarthritis; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Synovial Membrane; Urokinase-Type Plasminogen Activator	1990
[Clinical evaluation of diacerein in the treatment of osteoarthrosis]. Minerva medica, 1989, Volume: 80, Issue:9 Topics: Aged; Aged, 80 and over; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Diarrhea; Drug Evaluation; Female; Humans; Male; Middle Aged; Osteoarthritis; Time Factors	1989
[Diacetylrhein in the treatment of degenerative arthropathies]. La Clinica terapeutica, 1985, Mar-15, Volume: 112, Issue:5 Topics: Anthraquinones; Female; Humans; Male; Middle Aged; Osteoarthritis	1985