dextrorphan and Heroin-Dependence
dextrorphan has been researched along with Heroin-Dependence* in 1 studies
Other Studies
1 other study(ies) available for dextrorphan and Heroin-Dependence
| Article | Year |
|---|---|
Stereospecific opiate binding in human erythrocyte membranes and changes in heroin addicts.
Stereospecific opiate binding has been demonstrated in human erythrocyte membranes, having a Kd of 9-10(-9) M. In most respects the binding characteristics resemble those of synaptic membranes. These included the correlation of binding affinity and pharmacological potency of opiates; competition by naloxone; inhibition by Ca2+ and Na+; and sensitivity to phospholipases and trypsin. A comparison of stereospecific opiate binding in control human subjects and heroin addicts revealed a 43% increase in the addict group. Topics: Adult; Brain; Calcium Chloride; Dextrorphan; Erythrocyte Membrane; Erythrocytes; Female; Heroin Dependence; Humans; Hydromorphone; Kinetics; Levorphanol; Male; Morphinans; Phospholipases; Receptors, Opioid; Serine; Sodium Chloride; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Trypsin | 1976 |