dextromethorphan has been researched along with Herpes-Zoster* in 2 studies
1 trial(s) available for dextromethorphan and Herpes-Zoster
Article | Year |
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[Analgesic effect of dextromethorphan for postherpetic neuralgia].
We investigated the analgesic effect of dextromethorphan (DM), a non-selective NMDA receptor antagonist, in 25 patients with postherpetic neuralgia (PHN). We administered DM 45mg.day-1 orally for 14 days and then 90mg.day-1 for next 14 days. Decrease in pain intensity and alleviation of allodynia were observed in 9 patients (36%). Side effects with no severe cases occurred in 8 patients (32%) and these were mainly digestive symptoms. We concluded that DM might be useful to treat PHN with allodynia probably due to central sensitization. Topics: Aged; Analgesics; Dextromethorphan; Female; Herpes Zoster; Humans; Male; Middle Aged; Neuralgia; Receptors, N-Methyl-D-Aspartate | 1996 |
1 other study(ies) available for dextromethorphan and Herpes-Zoster
Article | Year |
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Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post-herpetic neuralgia.
N-methyl-D-aspartate (NMDA) receptors are involved in the development of neuropathic pain. Ketamine, a non-competitive NMDA receptor antagonist, has in several case reports given pain relief but efficacy in dosages tolerated in long-term ketamine treatment is unknown. Another substance with an antagonist action at NMDA receptors and which is approved for peroral administration is dextromethorphan. In a randomized study dextromethorphan was no better than placebo for neuropathic pain but this does not exclude efficacy in selected patients. We report a patient with severe post-herpetic pain resistant to conventional pain treatment which was treated with ketamine for 4 years with good pain relief. The practical application of long-term treatment in different administration forms of ketamine is described. The patient also responded with pain relief in a double-blind trial with oral dextromethorphan. Topics: Aged; Dextromethorphan; Excitatory Amino Acid Antagonists; Herpes Zoster; Humans; Ketamine; Male; Neuralgia; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Time Factors | 1997 |