dextromethorphan has been researched along with Epilepsies--Myoclonic* in 3 studies
3 other study(ies) available for dextromethorphan and Epilepsies--Myoclonic
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Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy.
Epileptic encephalopathy with suppression-burst in electroencephalography (EEG) can evolve into a few types of epileptic syndromes. We present here an unusual case of early myoclonic encephalopathy that evolved into migrating partial seizures in infancy. A female neonate initially had erratic myoclonus movements, hiccups, and a suppression-burst pattern in EEG that was compatible with early myoclonic encephalopathy. The seizures were controlled with dextromethorphan (20 mg/kg), and a suppression-burst pattern in EEG was reverted to relatively normal background activity. However, at 72 days of age, alternating focal tonic seizures, compatible with migrating partial seizures in infancy, were demonstrated by the 24-hour EEG recording. The seizures responded poorly to dextromethorphan. To our knowledge, this is the first reported case of early myoclonic encephalopathy evolving into migrating partial seizure in infancy. Whether it represents another age-dependent epilepsy evolution needs more clinical observation. Topics: Anticonvulsants; Dextromethorphan; Disease Progression; Epilepsies, Myoclonic; Epilepsies, Partial; Female; Humans; Infant; Infant, Newborn | 2012 |
High-frequency rhythmic cortical myoclonus in a long-surviving patient with nonketotic hypergylcemia.
An 11-year-old girl with nonketotic hyperglycinemia who typically presented with a picture of early myoclonic encephalopathy in the neonatal period is presented in this article. Treated early with sodium benzoate and dextromethorphan, she became seizure-free, while myoclonus persisted. During examination, multifocal rhythmic myoclonic jerks in gamma frequency enhanced by motor activity were noted. Coherence analysis of the electroencephalography-electromyography relationship indicated a cortical origin of the myoclonic jerks. Observation of this case suggests that rhythmic cortical myoclonus may represent a late evolution of this rare disorder. Topics: Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Dextromethorphan; Disease Progression; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Hyperglycinemia, Nonketotic; Infant; Infant, Newborn; Magnetic Resonance Imaging; Movement Disorders; Myoclonus; Sodium Benzoate; Survivors | 2008 |
Efficacy of low-dose dextromethorphan in the treatment of nonketotic hyperglycinemia.
Nonketotic hyperglycinemia (NKH) is an inborn error of glycine degradation causing muscular hypotonia, seizures, apnea, and lethargy; it has a poor prognosis. Accumulation of glycine in the brain is thought to cause excessive stimulation of the N-methyl-D-aspartate receptor. Dextromethorphan (DM), an N-methyl-D-aspartate receptor antagonist, in doses of 5 to 35 mg/kg per day has been shown to have beneficial therapeutic effects in some patients with NKH. We report the case of a 1-year-old infant with NKH, seizure disorder, and psychomotor delay who was clinically seizure free during treatment with sodium benzoate, arginine, benzodiazepam, and phenobarbital. Although sodium benzoate normalized serum glycine levels (103 to 125 mumol/L), cerebrospinal fluid glycine levels remained elevated (42 to 47 mumol/L), with epileptiform activity on electroencephalography. The addition of low-dose DM (0.25 mg/kg per day) to the treatment led to improvement of electroencephalographic activity, resolution of nystagmus with increased eye contact, and modest progression of developmental milestones. These data suggest that DM at doses significantly lower than previously reported may be beneficial in some patients with NKH. Treatment with low-dose DM needs further evaluation. Topics: Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Dextromethorphan; Electroencephalography; Epilepsies, Myoclonic; Glycine; Humans; Infant; Male; Receptors, N-Methyl-D-Aspartate | 1996 |