dextromethorphan and Dizziness

dextromethorphan has been researched along with Dizziness* in 3 studies

Reviews

1 review(s) available for dextromethorphan and Dizziness

ArticleYear
A teenager with focal weakness.
    Pediatric emergency care, 2008, Volume: 24, Issue:12

    Topics: Adolescent; Arm; Dextromethorphan; Diagnosis, Differential; Dizziness; Heroin Dependence; Humans; Ischemia; Magnetic Resonance Imaging; Male; Marijuana Abuse; Muscle Weakness; Myelitis, Transverse; Opioid-Related Disorders; Quadriplegia; Remission, Spontaneous; Smoking; Spinal Cord; Substance Abuse, Intravenous; Urinary Retention

2008

Trials

2 trial(s) available for dextromethorphan and Dizziness

ArticleYear
Analgesic effect of dextromethorphan in neuropathic pain.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:3

    Dextromethorphan, a clinically available N-methyl-D-aspartic acid (NMDA) receptor antagonist, has an analgesic effect in patients with diabetic neuropathy. The aim of this study was to evaluate the analgesic and adverse effects of a single high dose of dextromethorphan on spontaneous pain in patients suffering long-term neuropathic pain of traumatic origin.. Fifteen patients with post-traumatic neuropathic pain participated in this placebo-controlled, double-blind, randomized crossover study. On two separate occasions, the participants received 270 mg of dextromethorphan hydrobromide or placebo. Pain intensity, adverse effects and serum concentrations of dextromethorphan and metabolites were registered.. Dextromethorphan had a statistically significant analgesic effect compared with placebo, but the effect varied markedly among the patients. Light-headedness was the most important adverse effect reported. Extensive metabolizers of dextromethorphan had an apparently better analgesic effect than poor metabolizers.. This report indicates that a single high dose of dextromethorphan has an analgesic effect in patients with neuropathic pain of traumatic origin. The main metabolite dextrorphan seems to be important for the analgesic effect. At the relatively high dose studied, the clinical usefulness of dextromethorphan is limited to that portion of the patient population experiencing analgesia without an unacceptable level of adverse effects.

    Topics: Adult; Aged; Analgesics; Chronic Disease; Cross-Over Studies; Dextromethorphan; Dextrorphan; Dizziness; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuralgia; Pain Measurement; Placebos; Receptors, N-Methyl-D-Aspartate; Sleep Stages; Wounds and Injuries

2004
Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr.
    Journal of clinical pharmacology, 2001, Volume: 41, Issue:5

    Linezolid is a novel oxazolidinone antibiotic with mild reversible monoamine oxidase inhibitor (MAOI) activity. The potential for interaction with over-the-counter (OTC) medications requires quantification. The authors present data evaluating the pharmacokinetic and pharmacodynamic responses to coadministration of oral linezolid with sympathomimetics (pseudoephedrine and phenylpropanolamine) and a serotonin reuptake inhibitor (dextromethorphan). Following coadministration with linezolid, minimal but statistically significant increases were observed in pseudoephedrine and phenylpropanolamine plasma concentrations; a minimal but statistically significant decrease was observed in dextrorphan (the primary metabolite of dextromethorphan) plasma concentrations. Increased blood pressure (BP) was observed following the coadministration of linezolid with either pseudoephedrine or phenylpropanolamine; no significant effects were observed with dextromethorphan. None of these coadministered drugs had a significant effect on linezolid pharmacokinetics. Minimal numbers of adverse events were reported. Potentiation of sympathomimetic activity by linezolid was judged not to be clinically significant, but patients sensitive to the effects of increased BP due to predisposing factors should be treated cautiously. No restrictions are indicated for the coadministration of dextromethorphan and linezolid.

    Topics: Acetamides; Adult; Area Under Curve; Blood Pressure; Body Temperature; Dextromethorphan; Dizziness; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Ephedrine; Female; Headache; Heart Rate; Humans; Linezolid; Male; Mental Processes; Middle Aged; Monoamine Oxidase Inhibitors; Nonprescription Drugs; Oxazolidinones; Phenylpropanolamine; Regression Analysis; Sympathomimetics

2001
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