dextromethorphan and Bradycardia

dextromethorphan has been researched along with Bradycardia* in 1 studies

Other Studies

1 other study(ies) available for dextromethorphan and Bradycardia

ArticleYear
Developmental toxicity of dextromethorphan in zebrafish embryos/larvae.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:2

    Dextromethorphan is widely used in over-the-counter cough and cold medications. Its efficacy and safety for infants and young children remains to be clarified. The present study was designed to use zebrafish as a model to investigate the potential toxicity of dextromethorphan during embryonic and larval development. Three sets of zebrafish embryos/larvae were exposed to dextromethorphan at 24, 48 and 72 h post fertilization (hpf), respectively, during the embryonic/larval development. Compared with the 48 and 72 hpf exposure sets, the embryos/larvae in the 24 hpf exposure set showed much higher mortality rates which increased in a dose-dependent manner. Bradycardia and reduced blood flow were observed for the embryos/larvae treated with increasing concentrations of dextromethorphan. Morphological effects of dextromethorphan exposure, including yolk sac and cardiac edema, craniofacial malformation, lordosis, non-inflated swim bladder and missing gill, were also more frequent and severe among zebrafish embryos/larvae exposed to dextromethorphan at 24 hpf. Whether the more frequent and severe developmental toxicity of dextromethorphan observed among the embryos/larvae in the 24 hpf exposure set, as compared with the 48 and 72 hpf exposure sets, is due to the developmental expression of the phase I and phase II enzymes involved in the metabolism of dextromethorphan remains to be clarified. A reverse transcription-polymerase chain reaction analysis, nevertheless, revealed developmental stage-dependent expression of mRNAs encoding SULT3 ST1 and SULT3 ST3, two enzymes previously shown to be capable of sulfating dextrorphan, an active metabolite of dextromethorphan.

    Topics: Animals; Antitussive Agents; Behavior, Animal; Bradycardia; Craniofacial Abnormalities; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Edema, Cardiac; Embryo, Nonmammalian; Embryonic Development; Feeding Behavior; Gene Expression Regulation, Developmental; Larva; Regional Blood Flow; RNA, Messenger; Sulfotransferases; Teratogens; Yolk Sac; Zebrafish; Zebrafish Proteins

2011
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