dextromethorphan has been researched along with Arthritis--Rheumatoid* in 1 studies
1 other study(ies) available for dextromethorphan and Arthritis--Rheumatoid
| Article | Year |
|---|---|
Dextromethorphan Exhibits Anti-inflammatory and Immunomodulatory Effects in a Murine Model of Collagen-Induced Arthritis and in Human Rheumatoid Arthritis.
Dextromethorphan (d-3-methoxy-17-methylmorphinan, DXM) is a commonly used antitussive with a favorable safety profile. Previous studies have demonstrated that DXM has anti-inflammatory and immunomodulatory properties; however, the effect of DXM in rheumatoid arthritis (RA) remains unknown. Herein, we found that DXM treatment attenuated arthritis severity and proinflammatory cytokine expression levels, including TNF-α, IL-6, and IL-17A, in paw tissues of CIA mice. DXM treatment also reduced serum TNF-α, IL-6, and IL-17A levels of CIA mice and patients with RA. DXM further decreased the production of anti-CII IgG, IFN-γ, and IL-17A in collagen-reactive CD4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Collagen Type II; Cytokines; Dendritic Cells; Dextromethorphan; Disease Models, Animal; Humans; Immunologic Factors; Inflammation Mediators; Lymphocyte Activation; Male; Mice; T-Lymphocytes | 2017 |