dextroamphetamine has been researched along with Stroke in 18 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To collect data important for future studies evaluating the effect of dextroamphetamine combined with physiotherapy for improving poststroke motor recovery and to test the efficacy of the approach." | 9.27 | Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial. ( Dromerick, AW; Goldstein, LB; Good, DC; Lennihan, L; Pura, J; Rabadi, MJ; Reding, MJ; Samsa, GP, 2018) |
| " Increased intensity and longer duration drug/therapy dosing regimens should be explored, targeting the upper and lower limbs separately." | 6.72 | Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial. ( Armesto, A; Black, SE; Danells, CJ; Gladstone, DJ; Graham, SJ; Herrmann, N; McIlroy, WE; Staines, WR; Szalai, JP, 2006) |
| "To collect data important for future studies evaluating the effect of dextroamphetamine combined with physiotherapy for improving poststroke motor recovery and to test the efficacy of the approach." | 5.27 | Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial. ( Dromerick, AW; Goldstein, LB; Good, DC; Lennihan, L; Pura, J; Rabadi, MJ; Reding, MJ; Samsa, GP, 2018) |
| "Stroke is a physiological disorder involving a prolonged local interruption of cerebral blood flow." | 3.01 | Neurobiology of Amphetamine use in Stroke Recovery Combined with Rehabilitative Training and Brain Stimulation. ( Abualait, T; Al-Harbi, TM; Al-Harbi, ZT; Arshad, A; Arshad, M; Bashir, S; Fahad, RB; Uzair, M; Yoo, WK, 2023) |
| " Increased intensity and longer duration drug/therapy dosing regimens should be explored, targeting the upper and lower limbs separately." | 2.72 | Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial. ( Armesto, A; Black, SE; Danells, CJ; Gladstone, DJ; Graham, SJ; Herrmann, N; McIlroy, WE; Staines, WR; Szalai, JP, 2006) |
| " Adverse events, blood pressure, heart rate, body temperature, consciousness level, and functional outcome measures were followed up daily during treatment." | 2.71 | Safety of dexamphetamine in acute ischemic stroke: a randomized, double-blind, controlled dose-escalation trial. ( Martinsson, L; Wahlgren, NG, 2003) |
| " This study intended to investigate the effect of an increased intensity of physiotherapy in combination with dexamphetamine the first week after ischemic stroke in patients with an impaired level of consciousness and severe motor dysfunction." | 2.71 | Intensive early physiotherapy combined with dexamphetamine treatment in severe stroke: a randomized, controlled pilot study. ( Eksborg, S; Martinsson, L; Wahlgren, NG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (72.22) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Uzair, M | 1 |
| Arshad, M | 1 |
| Abualait, T | 1 |
| Al-Harbi, ZT | 1 |
| Al-Harbi, TM | 1 |
| Fahad, RB | 1 |
| Arshad, A | 1 |
| Yoo, WK | 1 |
| Bashir, S | 1 |
| Abe, H | 1 |
| Jitsuki, S | 1 |
| Takahashi, T | 1 |
| Keser, Z | 1 |
| Dehgan, MW | 1 |
| Shadravan, S | 1 |
| Yozbatiran, N | 1 |
| Maher, LM | 1 |
| Francisco, GE | 1 |
| Goldstein, LB | 3 |
| Lennihan, L | 1 |
| Rabadi, MJ | 1 |
| Good, DC | 1 |
| Reding, MJ | 1 |
| Dromerick, AW | 1 |
| Samsa, GP | 1 |
| Pura, J | 1 |
| Adkins, DL | 1 |
| Schallert, T | 1 |
| Barbay, S | 1 |
| Nudo, RJ | 1 |
| Schuster, C | 1 |
| Maunz, G | 1 |
| Lutz, K | 1 |
| Kischka, U | 1 |
| Sturzenegger, R | 1 |
| Ettlin, T | 1 |
| Martinsson, L | 3 |
| Wahlgren, NG | 2 |
| Long, D | 1 |
| Young, J | 1 |
| Eksborg, S | 2 |
| Gladstone, DJ | 1 |
| Danells, CJ | 1 |
| Armesto, A | 1 |
| McIlroy, WE | 1 |
| Staines, WR | 1 |
| Graham, SJ | 1 |
| Herrmann, N | 1 |
| Szalai, JP | 1 |
| Black, SE | 1 |
| Rasmussen, RS | 1 |
| Overgaard, K | 1 |
| Hildebrandt-Eriksen, ES | 1 |
| Boysen, G | 1 |
| Sonde, L | 1 |
| Lökk, J | 1 |
| Borlongan, CV | 1 |
| Hess, DC | 1 |
| Knecht, S | 1 |
| Imai, T | 1 |
| Kamping, S | 1 |
| Breitenstein, C | 1 |
| Henningsen, H | 1 |
| Lütkenhöner, B | 1 |
| Ringelstein, EB | 1 |
| Altieri, M | 1 |
| Di Piero, V | 1 |
| Lenzi, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amphetamine-Enhanced Stroke Recovery[NCT01905371] | Phase 2 | 99 participants (Actual) | Interventional | 2001-04-30 | Completed | ||
| Evaluation of the Therapeutic Effect of Amphetamine in Association to Physiotherapy on Motor Recovery After Stroke: a Randomised, Double-Blinded, Placebo-Controlled Trial[NCT00572767] | Phase 4 | 16 participants (Actual) | Interventional | 2001-01-31 | Terminated (stopped due to Intended length of study ended) | ||
| Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction[NCT02386475] | Phase 4 | 39 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for dextroamphetamine and Stroke
| Article | Year |
|---|---|
Neurobiology of Amphetamine use in Stroke Recovery Combined with Rehabilitative Training and Brain Stimulation.
Topics: Animals; Brain; Dextroamphetamine; Humans; Neuronal Plasticity; Quality of Life; Recovery of Functio | 2023 |
Pharmacological Enhancement of Stroke Rehabilitation.
Topics: Animals; Dextroamphetamine; Disease Models, Animal; Humans; Levodopa; Neuronal Plasticity; Randomize | 2019 |
The effects of amphetamine on recovery of function in animal models of cerebral injury: a critical appraisal.
Topics: Animals; Brain Injuries; Central Nervous System Stimulants; Dextroamphetamine; Disease Models, Anima | 2009 |
Amphetamines and related drugs in motor recovery after stroke.
Topics: Central Nervous System Stimulants; Dextroamphetamine; Humans; Methylphenidate; Motor Cortex; Movemen | 2003 |
Dexamphetamine treatment in stroke.
Topics: Animals; Brain Injuries; Central Nervous System Stimulants; Dextroamphetamine; Forecasting; Humans; | 2003 |
8 trials available for dextroamphetamine and Stroke
| Article | Year |
|---|---|
Combined Dextroamphetamine and Transcranial Direct Current Stimulation in Poststroke Aphasia.
Topics: Adult; Aged; Aged, 80 and over; Aphasia; Central Nervous System Stimulants; Combined Modality Therap | 2017 |
Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Central Nervous System Stimulants; Combined Modality | 2018 |
Dexamphetamine improves upper extremity outcome during rehabilitation after stroke: a pilot randomized controlled trial.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Analysis of Variance; Central Nervous System St | 2011 |
Safety of dexamphetamine in acute ischemic stroke: a randomized, double-blind, controlled dose-escalation trial.
Topics: Acute Disease; Administration, Oral; Aged; Blood Pressure; Body Temperature; Brain Ischemia; Conscio | 2003 |
Intensive early physiotherapy combined with dexamphetamine treatment in severe stroke: a randomized, controlled pilot study.
Topics: Aged; Aged, 80 and over; Central Nervous System Stimulants; Combined Modality Therapy; Dextroampheta | 2003 |
Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Cohort Studies; Dextroamphetamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Mod | 2006 |
Effects of amphetamine and/or L-dopa and physiotherapy after stroke - a blinded randomized study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Combined Modality Therapy; Dextroamphetamine; Dopamin | 2007 |
D-amphetamine does not improve outcome of somatosensory training.
Topics: Adult; Analysis of Variance; Dextroamphetamine; Discrimination Learning; Double-Blind Method; Drug A | 2001 |
5 other studies available for dextroamphetamine and Stroke
| Article | Year |
|---|---|
Poststroke treatment: lost in translation.
Topics: Age Factors; Animals; Brain; Central Nervous System Stimulants; Clinical Protocols; Clinical Trials | 2009 |
D-amphetamine improves cognitive deficits and physical therapy promotes fine motor rehabilitation in a rat embolic stroke model.
Topics: Animals; Central Nervous System Stimulants; Cognition Disorders; Dextroamphetamine; Disease Models, | 2006 |
Activity Index - a complementary ADL scale to the Barthel Index in the acute stage in patients with severe stroke.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Central Nervous System Stimulants; Dextroamphet | 2006 |
Stroke, with or with no ice? Observations on amphetamine for the management of acute stroke.
Topics: Acute Disease; Dextroamphetamine; Humans; Stroke | 2007 |
Drugs and recovery: a challenge for a few?
Topics: Aphasia; Bromocriptine; Contraindications; Dextroamphetamine; Dose-Response Relationship, Drug; Huma | 2002 |