dextroamphetamine and Mental Disorders studies

Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.

Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

Research Excerpts

Excerpt	Relevance	Reference
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."	7.63	Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
"Methylphenidate or dextroamphetamine was used to treat 17 of 32 patients with AIDS-related complex who were referred for neuropsychiatric evaluation of symptoms representative of cognitive and/or affective dysfunction."	5.06	Psychostimulant response in AIDS-related complex patients. ( Fernandez, F; Holmes, VF; Levy, JK, 1989)
"Seventy unwed pregnant patients in states of mild to moderate depression evidenced by one or more symptoms (tenseness, "nervousness," crying spells, listlessness, fatigue, nausea and vomiting, insomnia and overeating), received informal psychotherapy and a sustained-release capsule combining d-amphetamine sulfate and amobarbital."	3.63	Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. ( CALDWELL, WG; NOWERS, W, 1958)
"Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses."	2.67	Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment. ( Angrist, B; d'Hollosy, M; Diamond, G; Sanfilipo, M; Satriano, J; Simberkoff, M; Weinreb, H, 1992)
"Lisdexamfetamine dimesylate (LDX) is a long-acting oral prodrug stimulant."	2.50	The use of lisdexamfetamine dimesylate for the treatment of ADHD and other psychiatric disorders. ( Álvarez, FJ; Roncero, C, 2014)
" Often, these agents are used in combination with other medications."	1.30	Drug interactions with psychostimulants. ( DeVane, CL; Markowitz, JS; Morrison, SD, 1999)
"Bereavement after diagnosing AIDS or other HIV disease, psychological symptoms secondary to brain disease and the social consequences of having AIDS all interact to produce a devastating illness where the patient may be intensely grieving, demented and totally rejected by all of society."	1.27	Psychosocial aspects of AIDS. ( Goldmeier, D, 1987)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (62.50)	18.7374
1990's	7 (17.50)	18.2507
2000's	4 (10.00)	29.6817
2010's	4 (10.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Dalsgaard, S	1
Nielsen, HS	1
Simonsen, M	1
Roncero, C	1
Álvarez, FJ	1
Partyka, A	1
Jarosz, J	1
Wasik, A	1
Jastrzębska-Więsek, M	1
Zagórska, A	1
Pawłowski, M	1
Wesołowska, A	1
Wagner, D	1
Koester, P	1
Becker, B	1
Gouzoulis-Mayfrank, E	1
Hellmich, M	1
Daumann, J	1
GINN, SA	1
HOHMAN, LB	1
THORSEN, RK	2
CALDWELL, WG	1
NOWERS, W	1
HONIGFELD, G	1
HOLLAND, HC	1
LEHMANN, HE	1
BAN, TA	1
RANDRUP, A	1
MUNKVAD, I	1
SEATON, DA	2
ROSE, K	1
DUNCAN, LJ	2
ARTHUR, RJ	1
SETTEL, E	1
Fredriksson, A	1
Archer, T	1
Stewart, JW	1
Quitkin, FM	1
McGrath, PJ	1
Klein, DF	1
Sternberg, DE	1
Holmes, VF	2
Connor, DF	1
Benjamin, S	1
Ozbayrak, KR	1
Biederman, J	1
Byrne, JM	1
Bawden, HN	1
DeWolfe, NA	1
Beattie, TL	1
Markowitz, JS	1
Morrison, SD	1
DeVane, CL	1
Homsi, J	1
Walsh, D	1
Nelson, KA	1
Gadow, KD	1
Weiss, M	1
Carlin, AS	1
Stauss, FF	1
Adams, KM	1
Grant, I	1
Clark, AN	1
Markianos, ES	1
Nyström, I	1
Reichel, H	1
Matussek, N	1
Oswald, I	1
Maas, JW	1
Garver, D	1
Angrist, B	1
d'Hollosy, M	1
Sanfilipo, M	1
Satriano, J	1
Diamond, G	1
Simberkoff, M	1
Weinreb, H	1
Warneke, L	1
Fernandez, F	1
Levy, JK	1
Goldmeier, D	1
Barker, ET	1
Mason, MH	1
Parkes, JD	1
Fenton, G	1
Struthers, G	1
Curzon, G	1
Kantamaneni, BD	1
Buxton, BH	1
Record, C	1
Forman, MA	1
Hetznecker, W	1
Webb, WL	1
Marcucci, F	1
Mussini, E	1
Airoldi, L	1
Fanelli, R	1
Frigerio, A	1
de Nadai, F	1
Bizzi, A	1
Rizzo, M	1
Morselli, PL	1
Garattini, S	1
Duffy, JP	1
Davison, K	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417]			Phase 2	120 participants (Anticipated)	Interventional	2022-05-01	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
The use of lisdexamfetamine dimesylate for the treatment of ADHD and other psychiatric disorders. Expert review of neurotherapeutics, 2014, Volume: 14, Issue:8 Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Humans; Lisd	2014
Biologic tests in psychiatry. The Psychiatric clinics of North America, 1984, Volume: 7, Issue:3 Topics: Anxiety Disorders; Apomorphine; Clonidine; Dexamethasone; Dextroamphetamine; Growth Hormone; Humans;	1984
Medical use of psychostimulants: an overview. International journal of psychiatry in medicine, 1995, Volume: 25, Issue:1 Topics: Central Nervous System Stimulants; Depressive Disorder; Dextroamphetamine; Drug Interactions; Humans	1995
Attention-deficit/hyperactivity disorder: a life-span perspective. The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 7 Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hy	1998
Psychostimulants in supportive care. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2000, Volume: 8, Issue:5 Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Dextroamphetamine; Ephedrine; Humans; Men	2000
Psychostimulants in psychiatry. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1990, Volume: 35, Issue:1 Topics: Adult; Depressive Disorder; Dextroamphetamine; Female; Humans; Male; Mental Disorders; Methylphenida	1990
Child psychiatry. Progress in neurology and psychiatry, 1972, Volume: 27 Topics: Adolescent; Adoption; Child; Child Abuse; Child Behavior Disorders; Child Development; Child Psychia	1972

Article	Year
Clinical assessment of psychopharmacological treatment of preschoolers with ADHD. Journal of clinical and experimental neuropsychology, 1998, Volume: 20, Issue:5 Topics: Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child,	1998
Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adult; Dextroamphetamine; Humans; Male; Mental Disorders; Methyl	1992
Psychostimulant response in AIDS-related complex patients. The Journal of clinical psychiatry, 1989, Volume: 50, Issue:1 Topics: AIDS-Related Complex; Clinical Trials as Topic; Depressive Disorder; Dextroamphetamine; Humans; Male	1989

dextroamphetamine and Mental Disorders

Research Excerpts

Research

Studies (40)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Five-fold increase in national prevalence rates of attention-deficit/hyperactivity disorder medications for children and adolescents with autism spectrum disorder, attention-deficit/hyperactivity disorder, and other psychiatric disorders: a Danish registe Journal of child and adolescent psychopharmacology, 2013, Volume: 23, Issue:7 Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervou	2013
Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders. The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:12 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Male; Me	2014
A longitudinal study of self-reported psychopathology in early ecstasy and amphetamine users. Psychopharmacology, 2015, Volume: 232, Issue:5 Topics: Adolescent; Adult; Amphetamine-Related Disorders; Cohort Studies; Dextroamphetamine; Female; Humans;	2015
The use of dextro-amphetamine in severe behavior problems of children. Southern medical journal, 1953, Volume: 46, Issue:11 Topics: Amphetamine; Amphetamines; Behavior; Child; Dextroamphetamine; Humans; Mental Disorders	1953
[Abuse of dextro-amphetamine; case with endocrinological disturbance]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1956, Dec-01, Volume: 76, Issue:23 Topics: Amphetamine; Amphetamines; Dextroamphetamine; Endocrine Glands; Humans; Mental Disorders; Obesity	1956
[Abuse of dextro-amphetamine; case with endocrinological disturbance]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1956, Dec-01, Volume: 76, Issue:23 Topics: Amphetamine; Amphetamines; Dextroamphetamine; Endocrine Glands; Humans; Mental Disorders; Obesity	1956
[Abuse of dextro-amphetamine; case with endocrinological disturbance]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1956, Dec-01, Volume: 76, Issue:23 Topics: Amphetamine; Amphetamines; Dextroamphetamine; Endocrine Glands; Humans; Mental Disorders; Obesity	1956
[Abuse of dextro-amphetamine; case with endocrinological disturbance]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1956, Dec-01, Volume: 76, Issue:23 Topics: Amphetamine; Amphetamines; Dextroamphetamine; Endocrine Glands; Humans; Mental Disorders; Obesity	1956
Prepartum depression; a study of seventy unwed mothers treated with d-amphetamine sulfate and amobarbital. California medicine, 1958, Volume: 88, Issue:5 Topics: Amobarbital; Amphetamine; Amphetamines; Anxiety; Apathy; Depression; Depressive Disorder; Dextroamph	1958
Follow-up of depressed patients treated in a multi-hospital drug study. II. Psychiatric evaluations. Diseases of the nervous system, 1963, Volume: 24 Topics: Antidepressive Agents; Dextroamphetamine; Follow-Up Studies; Humans; Isocarboxazid; Mental Disorders	1963
MASSED PRACTICE AND REACTIVE INHIBITION, REMINISCENCE AND DISINHIBITION IN THE SPIRAL AFTER-EFFECT. British journal of psychology (London, England : 1953), 1963, Volume: 54 Topics: Adolescent; Amobarbital; Dextroamphetamine; Figural Aftereffect; Humans; Learning; Memory; Mental Di	1963
NOTES FROM THE LOG-BOOK OF A PSYCHOPHARMACOLOGICAL RESEARCH UNIT. II. Canadian Psychiatric Association journal, 1964, Volume: 9 Topics: Antidepressive Agents; Books; Dextroamphetamine; Diazepam; Geriatrics; Humans; Mental Disorders; Met	1964
ON THE RELATION OF TRYPTAMINIC AND SEROTONERGIC MECHANISMS TO AMPHETAMINE INDUCED ABNORMAL BEHAVIOUR. Acta pharmacologica et toxicologica, 1964, Volume: 21 Topics: Amphetamine; Amphetamines; Animals; Behavior, Animal; Cyproheptadine; Dextroamphetamine; Mental Diso	1964
A COMPARISON OF THE APPETITE SUPPRESSING PROPERTIES OF DEXAMPHETAMINE AND PHENTERMINE. Scottish medical journal, 1964, Volume: 9 Topics: Amphetamine; Amphetamines; Appetite; Appetite Depressants; Biomedical Research; Dextroamphetamine; D	1964
THE USES AND ABUSES OF APPETITE SUPPRESSANTS. The British journal of clinical practice, 1965, Volume: 19 Topics: Amphetamine; Amphetamines; Appetite Depressants; Delayed-Action Preparations; Dextroamphetamine; Dru	1965
THE NAVAL MEDICAL OFFICER AS A PSYCHIATRIC PATIENT. The American journal of psychiatry, 1965, Volume: 122 Topics: Antisocial Personality Disorder; Dextroamphetamine; Humans; Mental Disorders; Military Personnel; Mi	1965
Combined d-amphetamine and chlordiazepoxide therapy in the emotionally disturbed obese patient. Clinical medicine (Northfield, Ill.), 1963, Volume: 70 Topics: Amphetamine; Amphetamines; Chlordiazepoxide; Dextroamphetamine; Mental Disorders; Obesity	1963
Neurobehavioural deficits associated with apoptotic neurodegeneration and vulnerability for ADHD. Neurotoxicity research, 2004, Volume: 6, Issue:6 Topics: Animals; Animals, Newborn; Apoptosis; Attention Deficit Disorder with Hyperactivity; Central Nervous	2004
Defining the boundaries of atypical depression: evidence from the HPA axis supports course of illness distinctions. Journal of affective disorders, 2005, Volume: 86, Issue:2-3 Topics: Adult; Age of Onset; Circadian Rhythm; Comorbidity; Depressive Disorder; Dexamethasone; Dextroamphet	2005
Case study: neuroleptic withdrawal dyskinesia exacerbated by ongoing stimulant treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:11 Topics: Antipsychotic Agents; Dextroamphetamine; Diphenhydramine; Fluoxetine; Humans; Male; Mental Disorders	1995
Drug interactions with psychostimulants. International clinical psychopharmacology, 1999, Volume: 14, Issue:1 Topics: Anticonvulsants; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Dextroampheta	1999
Attention-deficit/hyperactivity disorder in adults: beyond controversy. Archives of general psychiatry, 2001, Volume: 58, Issue:8 Topics: Adult; Age Factors; Amphetamines; Attention Deficit Disorder with Hyperactivity; Comorbidity; Cross-	2001
The prediction of neuropsychological impairment in polydrug abusers. Addictive behaviors, 1978, Volume: 3, Issue:1 Topics: Adult; Alcoholism; Cannabis; Dextroamphetamine; Humans; Illicit Drugs; Life Style; Mental Disorders;	1978
Morale and motivation. The Practitioner, 1978, Volume: 220, Issue:1319 Topics: Aged; Dextroamphetamine; Diagnosis, Differential; Female; Humans; Male; Mental Disorders; Methylphen	1978
Serum dopamine-beta-hydroxylase in psychiatric patients and normals. Effect of d-amphetamine and haloperidol. Psychopharmacology, 1976, Nov-24, Volume: 50, Issue:3 Topics: Depression; Dextroamphetamine; Dopamine beta-Hydroxylase; Haloperidol; Humans; Mental Disorders; Sch	1976
Psychological medicine. Sleep difficulties. British medical journal, 1975, Mar-08, Volume: 1, Issue:5957 Topics: Aging; Beverages; Dextroamphetamine; Dreams; Female; Humans; Hypnotics and Sedatives; Male; Mental D	1975
Aminergic brain system interactions and psychopathology. Advances in biochemical psychopharmacology, 1975, Volume: 13 Topics: Animals; Behavior, Animal; Biogenic Amines; Depression; Dextroamphetamine; Drug Interactions; Female	1975
Psychosocial aspects of AIDS. British journal of hospital medicine, 1987, Volume: 37, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Attitude to Health; Brain Diseases; Child; Dementia; Dextroamphe	1987
Bubber behind bars. Canadian Psychiatric Association journal, 1968, Volume: 13, Issue:1 Topics: Amobarbital; Antisocial Personality Disorder; Attitude to Health; Audiovisual Aids; Communication; D	1968
Narcolepsy and cataplexy. Clinical features, treatment and cerebrospinal fluid findings. The Quarterly journal of medicine, 1974, Volume: 43, Issue:172 Topics: Adult; Amphetamine; Aspartic Acid; Body Weight; Cataplexy; Cerebrospinal Fluid Proteins; Dextroamphe	1974
The use of psychopharmacological drugs in the aged. Geriatrics, 1971, Volume: 26, Issue:6 Topics: Affective Symptoms; Aged; Antidepressive Agents; Anxiety; Barbiturates; Butyrophenones; Dementia; De	1971
Analytical and pharmacokinetic studies on butyrophenones. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 34, Issue:2 Topics: Adipose Tissue; Administration, Oral; Animals; Behavior, Animal; Brain; Butyrophenones; Chromatograp	1971
A female case of the Kleine-Levin Syndrome. The British journal of psychiatry : the journal of mental science, 1968, Volume: 114, Issue:506 Topics: Adolescent; Adult; Age Factors; Child; Dextroamphetamine; Feeding and Eating Disorders; Female; Huma	1968