dextroamphetamine has been researched along with Inadequate Sleep in 44 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dextroamphetamine (Dexedrine) is an effective fatigue countermeasure for use in military subject pilots who are deprived of sleep." | 5.10 | Utility of dextroamphetamine for attenuating the impact of sleep deprivation in pilots. ( Caldwell, JA; Caldwell, JL; Darlington, KK, 2003) |
| "Total sleep deprivation (TSD) results in an acute emotional perturbation, which yields a transient antidepressant effect." | 3.30 | Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder. ( Benes, H; Bhatacharya, A; Browning, M; Ceusters, M; de Boer, P; Drevets, WC; Jacobs, GE; Recourt, K; van der Ark, P; van Gerven, JMA; van Nueten, L, 2023) |
| "Regarding sleep deprivation, a main effect was found for four of the primary indicators and three of the secondary indicators." | 2.77 | Effects of d-amphetamine on simulated driving performance before and after sleep deprivation. ( Ceder, G; Fors, C; Forsman, A; Hjälmdahl, M; Kronstrand, R; Vadeby, A; Woxler, P, 2012) |
| "Following 47 h of sleep deprivation, the study examined the effect of three stimulant medications (modafinil 400 mg, dextroamphetamine 20 mg, caffeine 600 mg) or placebo on the ability of 54 healthy participants to discriminate and label simple emotional expressions versus complex affect blends (created by morphing photographs of two different affective facial expressions)." | 2.73 | The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation. ( Grugle, NL; Huck, NO; Kendall, AP; Killgore, WD; McBride, SA, 2008) |
| "Performance decrements with sleep deprivation occurred in visual scanning, running memory, logical reasoning, mathematical processing, the Stroop test, the time wall test, tracking and visual vigilance." | 2.71 | Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation. ( Bray, GA; Lieberman, HR; Magill, RA; McNevin, N; Ryan, DH; Smith, SR; Volaufova, J; Waters, WF, 2003) |
| "d-Amphetamine was more powerful than l-amphetamine in reversing sleep deprivation effects on vigilance and on waking EEG." | 2.64 | Sleep deprivation deficits and their reversal by d- and l-amphetamine. ( Branconnier, R; Hartmann, E; Orzack, MH, 1977) |
| "Our results indicate that REM sleep deprivation enhances the SMB induced by the daily administration of d-amphetamine and suggest the involvement of D1 DA receptors in the mechanism underlying the SMB." | 1.30 | Effects of REM sleep deprivation on the d-amphetamine-induced self-mutilating behavior. ( Drucker-Colín, R; Lara-Lemus, A; Méndez-Franco, J; Palomero-Rivero, M; Pérez de la Mora, M, 1997) |
| " In animal models, rapid eye movement (REM) sleep deprivation enhances the SMB induced by the chronic administration of d-amphetamine." | 1.30 | Biochemical effects induced by REM sleep deprivation in naive and in D-amphetamine treated rats. ( Drucker-Colín, R; Lara-Lemus, A; Méndez-Franco, J; Palomero-Rivero, M; Pérez de la Mora, M, 1998) |
| "However, increasing the period of sleep deprivation above 24 hours to 72 or 120 hours did not result in increased recovery sleep above that present in the 24-hour group." | 1.24 | Sleep deprivation in the rat. ( Levitt, RA, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (38.64) | 18.7374 |
| 1990's | 6 (13.64) | 18.2507 |
| 2000's | 13 (29.55) | 29.6817 |
| 2010's | 7 (15.91) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Recourt, K | 1 |
| de Boer, P | 1 |
| van der Ark, P | 1 |
| Benes, H | 1 |
| van Gerven, JMA | 1 |
| Ceusters, M | 1 |
| van Nueten, L | 1 |
| Drevets, WC | 1 |
| Bhatacharya, A | 1 |
| Browning, M | 1 |
| Jacobs, GE | 1 |
| Tselha, T | 1 |
| Whitehurst, LN | 1 |
| Yetton, BD | 1 |
| Vo, TT | 1 |
| Mednick, SC | 1 |
| Hanley, N | 1 |
| Paulissen, J | 1 |
| Eastwood, BJ | 1 |
| Gilmour, G | 2 |
| Loomis, S | 2 |
| Wafford, KA | 1 |
| McCarthy, A | 2 |
| Gasior, M | 1 |
| Freeman, J | 1 |
| Zammit, G | 1 |
| Donnelly, P | 1 |
| Gao, J | 1 |
| Ferreira-Cornwell, MC | 1 |
| Roth, T | 1 |
| Baxter, C | 1 |
| Kellett, DO | 1 |
| Edgar, DM | 1 |
| Tricklebank, M | 1 |
| Killgore, WD | 8 |
| Rupp, TL | 1 |
| Grugle, NL | 6 |
| Reichardt, RM | 1 |
| Lipizzi, EL | 1 |
| Balkin, TJ | 7 |
| Killgore, DB | 5 |
| Leavitt, BP | 1 |
| Watlington, GI | 1 |
| McNair, S | 1 |
| Muckle, AE | 1 |
| Kahn-Greene, ET | 1 |
| Hjälmdahl, M | 2 |
| Vadeby, A | 1 |
| Forsman, A | 2 |
| Fors, C | 1 |
| Ceder, G | 1 |
| Woxler, P | 1 |
| Kronstrand, R | 1 |
| Ramaekers, JG | 1 |
| Kuypers, KP | 1 |
| Bosker, WM | 1 |
| Brookhuis, KA | 1 |
| Veldstra, JA | 1 |
| Simons, R | 1 |
| Martens, M | 1 |
| Knoche, A | 1 |
| Buguet, A | 1 |
| Moroz, DE | 1 |
| Radomski, MW | 1 |
| Waters, WF | 2 |
| Magill, RA | 2 |
| Bray, GA | 2 |
| Volaufova, J | 2 |
| Smith, SR | 2 |
| Lieberman, HR | 2 |
| Rood, J | 1 |
| Hurry, M | 1 |
| Anderson, T | 1 |
| Ryan, DH | 2 |
| McNevin, N | 1 |
| Caldwell, JA | 5 |
| Caldwell, JL | 5 |
| Darlington, KK | 1 |
| Wesensten, NJ | 1 |
| McBride, SA | 2 |
| Eliyahu, U | 1 |
| Berlin, S | 1 |
| Hadad, E | 1 |
| Heled, Y | 1 |
| Moran, DS | 1 |
| Huck, NO | 1 |
| Kendall, AP | 1 |
| Tannhauser, SL | 1 |
| Tannhauser, M | 1 |
| Barros, HM | 1 |
| Corso, CO | 1 |
| Pinto-Netto, LM | 1 |
| Radulovacki, M | 1 |
| Zak, R | 1 |
| Crowley, JS | 1 |
| Jones, HD | 1 |
| Lara-Lemus, A | 2 |
| Pérez de la Mora, M | 2 |
| Méndez-Franco, J | 2 |
| Palomero-Rivero, M | 2 |
| Drucker-Colín, R | 2 |
| Baranski, JV | 1 |
| Pigeau, RA | 1 |
| Smythe, NK | 1 |
| Leduc, PA | 1 |
| Kitahama, K | 1 |
| Valatx, JL | 1 |
| Hartmann, E | 1 |
| Orzack, MH | 1 |
| Branconnier, R | 1 |
| Belleville, JP | 1 |
| Dorey, F | 1 |
| BEllville, JW | 1 |
| Collins, WE | 2 |
| Newhouse, PA | 1 |
| Belenky, G | 1 |
| Thomas, M | 1 |
| Thorne, D | 1 |
| Sing, HC | 1 |
| Fertig, J | 1 |
| Arriaga, F | 1 |
| Dugovic, C | 1 |
| Wauquier, A | 1 |
| Baust, W | 1 |
| Noppeney, H | 1 |
| Schlösser, A | 1 |
| Vogel, GW | 2 |
| Ananth, J | 1 |
| Ruskin, R | 1 |
| Griffith, JD | 1 |
| Cavanaugh, J | 1 |
| Held, J | 1 |
| Oates, JA | 1 |
| Hurst, PM | 1 |
| Chubb, NC | 1 |
| Bagley, SK | 1 |
| Ross, S | 1 |
| Loeb, M | 1 |
| Alluisi, EA | 1 |
| Traub, AC | 1 |
| Levitt, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Head-to-Head Comparison of the 2B-Alert Caffeine Optimization Algorithm Versus Standard Caffeine Dosing on Performance During Sleep Deprivation (2B-2)[NCT05588934] | 180 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dextroamphetamine and Inadequate Sleep
| Article | Year |
|---|---|
Modafinil--medical considerations for use in sustained operations.
Topics: Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Humans; Sleep; Sleep Deprivation | 2003 |
REM deprivation. 3. Dreaming and psychosis.
Topics: Anxiety; Behavior; Depression; Dextroamphetamine; Dreams; Drive; Eye Movements; Hallucinations; Huma | 1968 |
21 trials available for dextroamphetamine and Inadequate Sleep
| Article | Year |
|---|---|
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder.
Topics: Central Nervous System; Depressive Disorder, Major; Dextroamphetamine; Humans; Purinergic P2X Recept | 2023 |
Maintenance of wakefulness with lisdexamfetamine dimesylate, compared with placebo and armodafinil in healthy adult males undergoing acute sleep loss.
Topics: Administration, Oral; Adult; Benzhydryl Compounds; Dextroamphetamine; Double-Blind Method; Health St | 2014 |
Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness.
Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul | 2008 |
Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil.
Topics: Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Decision Making | 2008 |
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil.
Topics: Adolescent; Adult; Arousal; Attention; Benzhydryl Compounds; Caffeine; Central Nervous System Stimul | 2009 |
Odor identification ability predicts executive function deficits following sleep deprivation.
Topics: Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Executive Func | 2010 |
Effects of d-amphetamine on simulated driving performance before and after sleep deprivation.
Topics: Adult; Automobile Driving; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relat | 2012 |
A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Double-Blind Meth | 2003 |
Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation.
Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cognition; Dextroamphetamine; Double | 2003 |
Utility of dextroamphetamine for attenuating the impact of sleep deprivation in pilots.
Topics: Adult; Aerospace Medicine; Dextroamphetamine; Fatigue; Female; Humans; Male; Military Personnel; Pol | 2003 |
The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation.
Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex | 2006 |
The effects of modafinil, caffeine, and dextroamphetamine on judgments of simple versus complex emotional expressions following sleep deprivation.
Topics: Adolescent; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dex | 2008 |
Sustaining helicopter pilot performance with Dexedrine during periods of sleep deprivation.
Topics: Adult; Aerospace Medicine; Affect; Aircraft; Central Nervous System Stimulants; Dextroamphetamine; D | 1995 |
Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition; Dextroamphetamine; Double | 1997 |
Recovery sleep and performance following sleep deprivation with dextroamphetamine.
Topics: Adult; Affect; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Motor Act | 1997 |
An in-flight investigation of the efficacy of dextroamphetamine for sustaining helicopter pilot performance.
Topics: Adult; Aerospace Medicine; Aircraft; Arousal; Central Nervous System Stimulants; Dextroamphetamine; | 1997 |
Efficacy of Dexedrine for maintaining aviator performance during 64 hours of sustained wakefulness: a simulator study.
Topics: Adult; Aerospace Medicine; Affect; Aircraft; Central Nervous System Stimulants; Dextroamphetamine; D | 2000 |
Sleep deprivation deficits and their reversal by d- and l-amphetamine.
Topics: Adult; Amphetamine; Attention; Dextroamphetamine; Electroencephalography; Emotions; Humans; Male; Sl | 1977 |
Effects of nefopam on visual tracking.
Topics: Dextroamphetamine; Humans; Male; Motion Perception; Motor Skills; Nefopam; Oxazocines; Pentazocine; | 1979 |
The effects of d-amphetamine on arousal, cognition, and mood after prolonged total sleep deprivation.
Topics: Adult; Affect; Arousal; Behavior; Blood Pressure; Body Temperature; Cognition; Dextroamphetamine; Hu | 1989 |
Dextroamphetamine. Evaluation of psychomimetic properties in man.
Topics: Administration, Oral; Adult; Catecholamines; Central Nervous System; Clinical Trials as Topic; Depre | 1972 |
21 other studies available for dextroamphetamine and Inadequate Sleep
| Article | Year |
|---|---|
Morning stimulant administration reduces sleep and overnight working memory improvement.
Topics: Adult; Attention; Central Nervous System Stimulants; Cognition; Dextroamphetamine; Double-Blind Meth | 2019 |
Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist.
Topics: Amino Acids; Animals; Caffeine; Central Nervous System Stimulants; Cyclohexanes; Dextroamphetamine; | 2019 |
Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617.
Topics: Animals; Arousal; Benzhydryl Compounds; Biofeedback, Psychology; Caffeine; Central Nervous System St | 2015 |
Sex differences in cognitive estimation during sleep deprivation: effects of stimulant countermeasures.
Topics: Adenosine; Adult; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Cogn | 2008 |
Effects of stimulant drugs on actual and simulated driving: perspectives from four experimental studies conducted as part of the DRUID research consortium.
Topics: Automobile Driving; Central Nervous System Stimulants; Dextroamphetamine; Ethanol; Female; Humans; M | 2012 |
Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation.
Topics: Adult; Arousal; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Cognition; Dextro | 2005 |
Psychostimulants and military operations.
Topics: Adult; Benzhydryl Compounds; Central Nervous System Stimulants; Circadian Rhythm; Cognition; Dextroa | 2007 |
Effects of carbamazepine or imipramine alone or in association with amphetamine on the fighting time of REM sleep-deprived rats.
Topics: Aggression; Animals; Carbamazepine; Dextroamphetamine; Humans; Imipramine; Male; Rats; Rats, Inbred | 1984 |
Amphetamine abolishes REM sleep rebound in rats: effect of single injection.
Topics: Animals; Dextroamphetamine; Male; Rats; Sleep Deprivation; Sleep Stages; Sleep, REM; Wakefulness | 1981 |
Effects of REM sleep deprivation on the d-amphetamine-induced self-mutilating behavior.
Topics: Animals; Benzazepines; Central Nervous System Stimulants; Dextroamphetamine; Dopamine; Dopamine Anta | 1997 |
Biochemical effects induced by REM sleep deprivation in naive and in D-amphetamine treated rats.
Topics: Animals; Behavior, Animal; Brain; Dextroamphetamine; Dopamine; Dopamine Agents; Male; Norepinephrine | 1998 |
Strain differences in amphetamine sensitivity in mice. II. Overcompensation of paradoxical sleep after deprivation in two C57 strains.
Topics: Animals; Dextroamphetamine; Male; Methamphetamine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Sl | 1979 |
Some effects of sleep deprivation on tracking performance in static and dynamic environments.
Topics: Acceleration; Aerospace Medicine; Dextroamphetamine; Hallucinations; Humans; Male; Motor Skills; Sle | 1977 |
Effects of lithium on dopamine behavioural supersensitivity induced by rapid eye movement sleep deprivation.
Topics: Animals; Brain; Chlorides; Dextroamphetamine; Lithium; Lithium Chloride; Male; Motor Activity; Rats; | 1988 |
Some effects of sleep loss on vestibular responses.
Topics: Adult; Coriolis Force; Dextroamphetamine; Humans; Male; Nystagmus, Physiologic; Reaction Time; Rotat | 1988 |
[The influence of REM sleep deprivation on heart rate and respiration].
Topics: Adult; Analysis of Variance; Dextroamphetamine; Electroencephalography; Electromyography; Eye Moveme | 1972 |
Treatment of intractable depression.
Topics: Amantadine; Antidepressive Agents; Depression; Dextroamphetamine; Drug Therapy, Combination; Hormone | 1974 |
Rebound from d-amphetamine.
Topics: Adult; Affect; Behavior; Dextroamphetamine; Female; Humans; Male; Sleep Deprivation; Sulfates; Task | 1971 |
Influence of display, task, and organismic variables on indices of monitoring behavior.
Topics: Arousal; Attention; Behavior; Circadian Rhythm; Data Display; Dextroamphetamine; Hot Temperature; Hu | 1970 |
REM deprivation. I. The effect on schizophrenic patients.
Topics: Adaptation, Physiological; Adult; Dextroamphetamine; Dreams; Electroencephalography; Eye Movements; | 1968 |
Sleep deprivation in the rat.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Motivation; Physical Exertion; Rats; Sleep; Sleep Depr | 1966 |