Page last updated: 2024-11-07

dextroamphetamine and Chemical Dependence

dextroamphetamine has been researched along with Chemical Dependence in 186 studies

Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.

Research Excerpts

ExcerptRelevanceReference
"Rating forms could quantify substance use interest in subjects with some drug culture exposure but encountered a floor effect in those without."2.76The "younger-sibling-at-risk design": a pilot study of adolescents with ADHD and an older sibling with substance use disorder. ( Donovan, SJ; Levin, FR, 2011)
"Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity."2.75Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users. ( Chakraborty, B; Manniche, PM; Meier, D; Schoedel, KA; Sellers, EM, 2010)
"Adult substance abusers were enrolled in this phase I, randomized, single-centre, double-blind study."2.74Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers. ( Jasinski, DR; Krishnan, S, 2009)
"Methylphenidate has potential for abuse because it produces behavioural effects similar to those observed with other abused stimulants, such as d-amphetamine and cocaine."2.71Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans. ( Fillmore, MT; Glaser, PE; Rush, CR; Stoops, WW, 2004)
" A secondary goal was to determine the accuracy of Drug Recognition Examiners (DREs) in detecting if subjects were dosed with these drugs."2.69Laboratory validation study of drug evaluation and classification program: alprazolam, d-amphetamine, codeine, and marijuana. ( Crouch, DJ; Heishman, SJ; Singleton, EG, 1998)
"Sibutramine (Meridia) is a serotonin and norepinephrine reuptake inhibitor marketed for weight control."2.69Abuse liability assessment of sibutramine, a novel weight control agent. ( Hopper, JA; Mendel, CM; Schuh, LM; Schuster, CR, 2000)
"Sertraline is an effective antidepressant acting as a selective serotonin reuptake inhibitor."2.68Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans. ( Busto, U; Kaplan, HL; Sellers, EM; Zawertailo, LA, 1995)
"Eight volunteers with histories of drug abuse participated in two experiments examining the modulation of drug choice by behavioral requirements following drug ingestion."2.67Modulation of drug reinforcement by behavioral requirements following drug ingestion. ( Griffiths, RR; Kirby, KC; Silverman, K, 1994)
"Ephedrine choice was positively associated with current use of marijuana and lower levels of baseline anxiety and hunger, as well as with lower scores on two scales measuring dimensions of the personality trait of harm avoidance."2.67Factors influencing the reinforcing and subjective effects of ephedrine in humans. ( Chait, LD, 1994)
" While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs."2.49Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013)
"Lisdexamfetamine dimesylate (LDX) is a once-daily medication approved by the US Food and Drug Administration for the management of attention-deficit/hyperactivity disorder (ADHD) in children (aged 6-12 years) and adults."2.45The efficacy and safety profile of lisdexamfetamine dimesylate, a prodrug of d-amphetamine, for the treatment of attention-deficit/hyperactivity disorder in children and adults. ( Najib, J, 2009)
"Psychotherapy is still the mainstay of treatment; however, relapse rates are high."2.44Pharmacotherapy of methamphetamine addiction: an update. ( Elkashef, A; Hanson, G; Tiihonen, J; Vocci, F; White, J; Wickes, W, 2008)
"Learning and memory processes and drug addiction also share intracellular signaling cascades and are associated with similar changes in synaptic plasticity."2.44[Memory processes and addiction: involvement of the calcineurin signaling pathway]. ( Biała, G, 2007)
"A challenge in drug dependence is to delineate long-term behavioral and neurochemical modifications induced by drugs of abuse."2.44Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse. ( Tassin, JP, 2008)
"Amphetamines evaluated were D- and D,L-amphetamine and methamphetamine."2.43NTP-CERHR monograph on the potential human reproductive and developmental effects of amphetamines. ( , 2005)
"However, current substance abuse precludes use of the drug and former abuse liability and social adjustment problems are relative contraindications."2.40[Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders]. ( Aanonsen, NO, 1999)
" We considered two independent studies that used different dosing regimens where subjects completed the drug effects questionnaire at multiple time points post d-amphetamine."1.43Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology. ( Cowan, RL; de Wit, H; Kessler, RM; Palmer, AA; Smith, CT; Weafer, J; Zald, DH, 2016)
"Diagnoses of SUD and alcohol abuse were obtained from The Danish Psychiatric Central Register."1.40ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study. ( Dalsgaard, S; Frydenberg, M; Mortensen, PB; Thomsen, PH, 2014)
" After acquiring the discrimination, the effects of cocaine (0, 25, 50, 100 and 200 mg) administered alone and in combination with aripiprazole (15 mg) were determined."1.37Discriminative stimulus, subject-rated and cardiovascular effects of cocaine alone and in combination with aripiprazole in humans. ( Glaser, PE; Hays, LR; Lile, JA; Rush, CR; Stoops, WW, 2011)
"BP 897 was tested for its ability to support self-administration in rhesus monkeys (0."1.31The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered. ( Balster, RL; Beardsley, PM; Schwartz, JC; Sokoloff, P, 2001)
"Aminorex is a cyclic phenylisopropylamine that has been marketed as an anorectic."1.29Evaluation of the abuse liability of aminorex. ( Harris, LS; Massey, BW; Patrick, GA; Winger, G; Woolverton, WL, 1994)
"(+)-AJ 76 is a presumed preferential dopamine (DA) autoreceptor antagonist which, in previous behavioral investigations, has displayed properties characteristic of both DA agonists and DA antagonists."1.29Antagonism of cocaine self-administration by the preferential dopamine autoreceptor antagonist, (+)-AJ 76. ( Collins, RJ; Myers, JE; Piercey, MF; Richardson, NR; Roberts, DC; Svensson, K, 1993)
"Fluoxetine pretreatment, likewise, reduced responding in non-lesioned rats and had no observable effect in lesioned animals."1.27The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. ( Leccese, AP; Lyness, WH, 1984)
"Nefopam was most frequently identified by subjects as being amphetamine-like, though several measures indicated that nefopam produced some sedation."1.27A comparative assay of nefopam, morphine and d-amphetamine. ( Jasinski, DR; Preston, KL, 1987)
"Bereavement after diagnosing AIDS or other HIV disease, psychological symptoms secondary to brain disease and the social consequences of having AIDS all interact to produce a devastating illness where the patient may be intensely grieving, demented and totally rejected by all of society."1.27Psychosocial aspects of AIDS. ( Goldmeier, D, 1987)
"5 microliter of a d-amphetamine solution dosed at 7."1.26[Effects of lesions of the anterior raphe nuclei on the self-administration of d-amphetamine in the rat : considerable increase of desire for the poison]. ( Le Moal, M; Simon, H; Stinus, L, 1980)
"Hooded rats were injected with physiological saline or d-amphetamine sulfate for 13 days on a schedule designed to mimic patterns of abuse: one injection on days 1-11, two injections on day 12, and three injections on day 13; amphetamine dosage for the first three injections was 3."1.26Chronic amphetamine: effects on defensive flight in the rat. ( Mollenauer, S; Pipkin, B; Plotnik, R; White, M, 1982)
"Real life drug abusers ten to utilize drugs in a cyclic pattern of intermittently increasing doses and then "crashing off" depending on the availability of drugs and psychiatric treatment."1.26Dopamine receptors hypersensitivity: further confirmation following drug abuse model. ( Flemenbaum, A, 1977)

Research

Studies (186)

TimeframeStudies, this research(%)All Research%
pre-199099 (53.23)18.7374
1990's19 (10.22)18.2507
2000's40 (21.51)29.6817
2010's24 (12.90)24.3611
2020's4 (2.15)2.80

Authors

AuthorsStudies
Negus, SS2
Banks, ML1
McNealy, KR1
Houser, SD1
Barrett, ST1
Bevins, RA1
Langenecker, SA1
Kling, LR1
Crane, NA1
Gorka, SM1
Nusslock, R1
Damme, KSF1
Weafer, J2
de Wit, H7
Phan, KL1
Hoots, JK1
Webber, HE1
Nunez, C1
Cooper, JA1
Lopez-Gamundi, P1
Lawlor, VM1
Lane, SD1
Treadway, MT1
Wardle, MC2
Schrantee, A1
Václavů, L1
Reneman, L1
Verberne, HJ1
Booij, J1
Tan, HL1
Wright, JM1
Ren, S1
Constantin, A1
Clarke, PBS1
MacKillop, J1
Goldenson, NI1
Kirkpatrick, MG1
Leventhal, AM1
Jackson, C1
van Staaden, M1
Hudzik, TJ1
Basso, A1
Boyce-Rustay, JM1
Bracken, W1
Browman, KE1
Drescher, K1
Esbenshade, TA1
Loberg, LI1
Lynch, JJ1
Brioni, JD1
Toledano, D1
Tassin, JP3
Gisquet-Verrier, P1
Reynolds, AR2
Bolin, BL2
Stoops, WW5
Rush, CR6
Dalsgaard, S1
Mortensen, PB1
Frydenberg, M1
Thomsen, PH1
Chen, LY1
Crum, RM1
Strain, EC1
Martins, SS1
Mojtabai, R1
Marcus, BA1
Barkla, XM1
McArdle, PA1
Newbury-Birch, D1
Smith, CT1
Cowan, RL1
Kessler, RM1
Palmer, AA2
Zald, DH1
Eggleston, W1
Stork, C1
Jasinski, DR4
Krishnan, S2
Howland, RH1
Elkashef, A1
Vocci, F1
Hanson, G1
White, J1
Wickes, W1
Tiihonen, J1
Najib, J1
Miranda, F1
Jiménez, JC1
Cedillo, LN1
Sandoval-Sánchez, A1
Millán-Mejía, P1
Sánchez-Castillo, H1
Velázquez-Martínez, DN1
McCormick, CG1
Henningfield, JE3
Haddox, JD1
Varughese, S1
Lindholm, A1
Rosen, S1
Wissel, J1
Waxman, D1
Carter, LP1
Seeger, V1
Johnson, RE1
Hamidovic, A2
Childs, E2
Conrad, M1
King, A1
Herin, DV1
Grabowski, J1
Schoedel, KA1
Meier, D1
Chakraborty, B1
Manniche, PM1
Sellers, EM2
Lile, JA2
Glaser, PE3
Hays, LR1
Dlugos, AM1
Hodgkinson, C1
Shen, PH1
Goldman, D1
Steinkellner, T1
Freissmuth, M1
Sitte, HH1
Montgomery, T1
Donovan, SJ1
Levin, FR1
Estrada, A1
Kelley, AM1
Webb, CM1
Athy, JR1
Crowley, JS1
Frölich, J1
Banaschewski, T2
Spanagel, R1
Döpfner, M1
Lehmkuhl, G1
Cortese, S1
Holtmann, M1
Buitelaar, J1
Coghill, D1
Danckaerts, M1
Dittmann, RW1
Graham, J1
Taylor, E1
Sergeant, J1
Kulcsar, IS1
Saiz Ruiz, J1
Saiz González, D1
Antón Fructuoso, P1
Adriani, W1
Laviola, G1
BACHRICH, PR1
DAVIDSON, HA1
PROUT, CT1
OSWALD, I1
THACORE, VR1
ARTHUR, RJ1
Kollins, SH1
Tancer, M1
Johanson, CE12
Gordon, SM1
Tulak, F1
Troncale, J1
Odum, AL1
Shahan, TA1
Morley, KC1
Cornish, JL1
Li, KM1
McGregor, IS1
Gasior, M1
Bergman, J1
Kallman, MJ1
Paronis, CA1
Fillmore, MT1
McCabe, SE1
Knight, JR1
Teter, CJ1
Wechsler, H1
Biala, G1
Betancur, C1
Mansuy, IM1
Giros, B1
Yasar, S1
Gaál, J1
Panlilio, LV1
Justinova, Z1
Molnár, SV1
Redhi, GH1
Schindler, CW1
Ninkovic, J1
Bally-Cuif, L1
Dommett, EJ1
Simpson, J1
Clark, D1
Overton, PG1
Greenhill, LL1
Kliethermes, CL1
Kamens, HM1
Crabbe, JC2
Mello, NK1
Wu, LT1
Pilowsky, DJ1
Schlenger, WE1
Galvin, DM1
Biała, G1
Elia, J1
Easley, C1
Kirkpatrick, P1
Novak, SP1
Kroutil, LA1
Williams, RL1
Van Brunt, DL1
Faraone, SV1
Upadhyaya, HP1
Takahashi, RN1
Singer, G1
Kalix, P1
Griffith, JD2
Carranza, J1
Griffith, C1
Miller, LL1
Miller, L1
Griffith, J1
Kilgore, K2
Uhlenhuth, EH8
Shuster, L2
Leccese, AP1
Lyness, WH1
Clampit, MK1
Pirkle, JB1
Glowa, JR1
Barrett, JE2
Carroll, ME2
Stotz, DC1
Simon, H3
Stinus, L2
Le Moal, M3
Bradford, LD1
Griffiths, RR4
Kobasa, SC1
Thompson, T2
Mollenauer, S1
White, M1
Plotnik, R1
Pipkin, B1
Fischman, MW3
Schuster, CR3
D'Souza, T1
Shraberg, D1
Cahill, DW1
Knipp, H1
Mosser, J1
Schiff, SR1
Shannon, HE1
Degregorio, CM1
Lamb, RJ2
Zawertailo, LA1
Busto, U1
Kaplan, HL1
Silverman, K1
Kirby, KC1
Chait, LD3
Woolverton, WL3
Massey, BW1
Winger, G2
Patrick, GA1
Harris, LS1
Ellison, G1
Switzer, RC1
Richardson, NR1
Piercey, MF1
Svensson, K1
Collins, RJ1
Myers, JE1
Roberts, DC1
Block, RW1
Lac, ST1
Koob, GF2
France, CP1
Gerak, LR1
Rowlett, JK1
Woods, JH1
Heishman, SJ1
Singleton, EG1
Crouch, DJ1
Heyne, A1
Wolffgramm, J1
Aanonsen, NO1
Schuh, LM1
Hopper, JA1
Mendel, CM1
Homsi, J1
Walsh, D1
Nelson, KA1
Solbrig, MV1
Parsons, LH1
Kadota, T1
Horscroft, N1
Briese, T1
Lipkin, WI1
Di Ciano, P1
Blaha, CD1
Phillips, AG1
Beardsley, PM1
Sokoloff, P1
Balster, RL2
Schwartz, JC1
Drouin, C1
Darracq, L1
Trovero, F1
Blanc, G1
Glowinski, J1
Cotecchia, S1
Brady, JV1
Snell, JD1
Bigelow, GE1
Liebson, I1
Kaliszak, J1
Cole, SO1
Götestam, KG1
Flemenbaum, A3
Carlin, AS1
Stauss, FF1
Adams, KM1
Grant, I1
Altshuler, H1
Weaver, S1
Phillips, P1
Guerrant, GO1
Hall, CT1
Wright, CB1
Lamoy, RE1
Hobson, RW1
Ksir, C1
Levee, JR1
Cohen, MJ1
Rickles, WH1
Oviasu, VO1
Allen, RP1
Safer, D1
Covi, L1
Pickens, R1
Webster, GW1
Yu, G1
Goudie, AJ1
Thornton, EW1
Nader, MA1
Tatham, TA1
Phillips, TJ1
Burkhart-Kasch, S1
Gwiazdon, CC1
Foltin, RW2
Kelly, TH1
Sherman, JP1
Leong, GB1
Shaner, AL1
Silva, JA1
Piazza, PV1
Deminière, JM1
de la Garza, R2
Preston, KL2
Corwin, RL1
Goldmeier, D1
Kornetsky, C1
Kato, S1
Bailey, DN1
Jatlow, PI1
Bewley, T1
Jarvis, JF1
Hoffmeister, F2
Goldberg, SR2
Schlichting, U1
Wuttke, W1
Newell, GR1
Henderson, BE1
Najjar, FB1
Bridi, G1
Rizk, G1
Eisenberg, L1
Cavanaugh, J1
Held, J1
Oates, JA1
Forman, MA1
Hetznecker, W1
Campbell, H2
Cline, W2
Evans, M2
Lloyd, J2
Peck, AW2
Omenn, GS1
Geller, I1
Hartmann, RJ1
Blum, K1
Davis, WM1
Smith, SG1
Chapple, PA1
Choulis, NH1
Pugliese, AC1
Sever, PS1
Caldwell, J1
Dring, LG1
Williams, RT1
Klein, DF1
Puri, SK1
Lal, H1
Sproule, BC1
Pahnke, WN1
Ellinwood, EH1
Cohen, S1
Deneau, G1
Yanagita, T1
Seevers, MH1
Ferris, GN1
Linn, LS1
Frings, CS1
Queen, C1
Foster, LB1
Todd, J1
Stoffer, SS1
Sapira, JD1
Tweeddale, DN1
Meketon, BF1
Lancaster, B1
Rockley, GJ1
Spark, D1
Papp, P1
Goodman, SJ1
Becker, DP1
Morgan, LK1
Sours, JA1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Preliminary Investigation of Individual Differences in Subjective Responses to D-amphetamine, Alcohol, and Delta-9-tetrahydrocannabinol[NCT02485158]28 participants (Actual)Interventional2013-07-31Completed
Premenstrual Hormonal and Affective State Evaluation (PHASE) Project[NCT03862469]120 participants (Anticipated)Interventional2019-09-26Recruiting
Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323]80 participants (Anticipated)Interventional2023-06-01Recruiting
Hypomania, Amphetamine, and Preferences for Sweets[NCT03810703]Phase 193 participants (Actual)Interventional2017-02-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in General Drug Effects (Drug Effects Questionnaire) at 120 Minutes After Drink Administraion

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm43.9223.7944.9229.3817.5
ALC Placebo Arm7.964.8311.085.086.54
AMP Arm27.0843.7511.9218.8845.38
AMP Placebo Arm11.927.0413.385.043.13
THC Arm24.081819.6321.969.92
THC Placebo Arm7.888.678.884.839.88

Change in General Drug Effects (Drug Effects Questionnaire) at 150 Minutes After Drink Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm30.8321.3340.7520.4612.58
ALC Placebo Arm4.632.424.292.135.04
AMP Arm19.7939.511.2516.3344.08
AMP Placebo Arm5.836.748.092.872.87
THC Arm18.6311.7117.7914.759.38
THC Placebo Arm4.634.966.421.966.21

Change in General Drug Effects (Drug Effects Questionnaire) at 180 Minutes After Drink Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm22.219.0429.514.137.0
ALC Placebo Arm2.081.754.291.254.04
AMP Arm16.1331.0811.5411.6738.38
AMP Placebo Arm3.52.544.251.632.46
THC Arm15.677.3316.1311.7910.04
THC Placebo Arm2.544.04.631.045.04

Change in General Drug Effects (Drug Effects Questionnaire) at 210 Minutes After Drink Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm12.887.3322.719.214.54
ALC Placebo Arm0.960.251.290.833.83
AMP Arm11.0818.388.546.2532.5
AMP Placebo Arm2.171.967.460.332.25
THC Arm5.794.886.834.968.79
THC Placebo Arm1.084.384.540.426.17

Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Capsule Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm12.8318.6711.718.8313.5
ALC Placebo Arm9.3810.0411.05.53.71
AMP Arm4.7916.084.213.2914.21
AMP Placebo Arm12.179.010.716.965.63
THC Arm11.0811.7512.3810.586.54
THC Placebo Arm4.59.670.833.6711.0

Change in General Drug Effects (Drug Effects Questionnaire) at 30 Minutes After Drink Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm76.8345.0843.9650.3824.75
ALC Placebo Arm17.8314.3816.6811.510.0
AMP Arm43.4253.8815.7130.542.17
AMP Placebo Arm21.5816.6317.7112.5410.96
THC Arm38.2528.7525.6331.7517.46
THC Placebo Arm18.6325.2915.7912.9618.96

Change in General Drug Effects (Drug Effects Questionnaire) at 90 Minutes After Drink Administration

Drug effects will be measured using the Drug Effects Questionnaire (Fischman & Foltin, 1991). The DEQ included 5 subscales; feeling, liking, and disliking the drug effect, feeling high, and wanting more of the drug. Each subscale ranged from 1(Not at all) to 100(Very much). The change in DFQ was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration.

,,,,,
Interventionunits on a scale (Mean)
DEQ FeelDEQ LikeDEQ DislikeDEQ HighDEQ More
ALC Arm61.2129.9250.4641.8325.88
ALC Placebo Arm12.7511.3815.337.257.71
AMP Arm34.9255.6716.5427.9250.21
AMP Placebo Arm16.4610.4217.546.836.54
THC Arm31.5420.0823.2529.2116.54
THC Placebo Arm13.1713.2515.967.5812.88

Change in Specific Drug Effects (Addiction Research Center Inventory) at 120 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 120 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 120 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm-0.33-1.130.79-2.045.461.08
ALC Placebo Arm-0.71-1.290.04-0.831.63-0.04
AMP Arm2.173.330.381.67-1.081.83
AMP Placebo Arm-0.17-0.125-0.13-11.710.25
THC Arm-0.08-0.961-1.542.881.42
THC Placebo Arm-0.04-0.08-0.08-0.381.080.17

Change in Specific Drug Effects (Addiction Research Center Inventory) at 150 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 150 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 150 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm-0.54-1.540.79-2.045.460.75
ALC Placebo Arm-0.54-1.25-0.13-0.671.58-0.21
AMP Arm2.292.960.51.75-11.54
AMP Placebo Arm-0.130.130.09-0.430.650.22
THC Arm-0.17-0.960.58-1.292.580.83
THC Placebo Arm-0.08-0.08-0.17-0.420.790.08

Change in Specific Drug Effects (Addiction Research Center Inventory) at 180 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 180 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 180 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm-0.75-1.290.54-1.53.630.08
ALC Placebo Arm-0.33-1.08-0.04-0.380.71-0.13
AMP Arm1.581.920.461.13-0.461.21
AMP Placebo Arm-0.040.330.04-0.330.210.13
THC Arm-0.21-0.670.54-1.292.130.71
THC Placebo Arm-0.17-0.170.04-0.290.42-0.08

Change in Specific Drug Effects (Addiction Research Center Inventory) at 210 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects.The change in ARCI was assessed by the difference in measurements between baseline and 210 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 210 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm-0.71-1.170.33-1.253.170.08
ALC Placebo Arm-0.54-0.791.67-0.380.21-0.17
AMP Arm1.01.380.630.83-0.290.96
AMP Placebo Arm-0.170.130.25-0.17-0.290
THC Arm-0.46-0.880.54-0.831.040.21
THC Placebo Arm0.080.040.04-0.130.13-0.08

Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Capsule Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after capsule administration and before drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after capsule administration and before drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm0.25-0.290.33-0.751.290.83
ALC Placebo Arm-0.17-0.670.08-0.920.920.33
AMP Arm-0.17-0.580.13-0.460.580.08
AMP Placebo Arm-0.25-0.580.13-1.171.960.5
THC Arm-0.04-0.710.38-0.792.920.42
THC Placebo Arm0.540.33-0.170.250.420.42

Change in Specific Drug Effects (Addiction Research Center Inventory) at 30 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 30 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 30 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm1.921.382.63-0.883.713.42
ALC Placebo Arm-0.33-1.170.29-0.961.540.29
AMP Arm2.883.711.131.63-13.21
AMP Placebo Arm000.33-0.832.250.42
THC Arm0.17-0.541.54-1.382.962.04
THC Placebo Arm0.710.880.130.041.130.96

Change in Specific Drug Effects (Addiction Research Center Inventory) at 90 Minutes After Drink Administration

Specific drug effects will be measured using the Addiction Research Center Inventory (Martin et al. 1971). The ARCI measures effects specific to drug classes, including the effects of AMP-like drugs (A scale, 0 to 11), morphine and benzedrine like drugs (MBG scale, 0 to 14), lysergic acid-like drugs (LSD scale, 0 to 14), benzedrine-like drugs (BG scale, 0 to 13), pentobarbital-chlorpromazine and ALC-like drugs (PCAG scale, 0 to 15), and cannabis-like drugs (M scale, 0 to 12). We used this questionnaire as a manipulation check to ensure that the drugs produced their typical drug-specific effects in this study. For example, zero value of A sacle would be minimum report of amphetamine-like drug effects, and 11 would be maximum report of amphetamine-like effects. The change in ARCI was assessed by the difference in measurements between baseline and 90 minutes after drink administration. Baseline was measure 15 minutes prior to capsule administration. (NCT02485158)
Timeframe: Measured 15 minutes prior to capsule administration and 90 minutes after drink administration

,,,,,
Interventionunits on a scale (Mean)
ARC AARC MBGARC LSDARC BGARC PCAGARC M
ALC Arm0.29-0.381.79-2.546.212.25
ALC Placebo Arm-0.58-1.290.29-1.131.920.13
AMP Arm2.963.671.082.17-1.212.63
AMP Placebo Arm-0.33-0.29-0.04-1.292.670.42
THC Arm0-0.831.42-1.713.542.04
THC Placebo Arm-0.08-0.130.08-0.671.580.29

"Change in Subjective Effects as Assessed by Score on Feel Drug, Feel High, Like Drug, and Want More Sub-scales of Drug Effects Questionnaire (DEQ)."

"Participants will complete The Drug Effects Questionnaire during the initial baseline session to determine their subjective stimulant profile. The Dug Effects Questionnaire (DEQ) is a visual analog scale questionnaire that assesses the extent to which subjects experience four subjective states: Feel Drug, Feel High, Like Drug, and Want More. All sub-scales are scored on a visual analogue scale (Scroll bar on computer screen) ranging from 0-100. 100 represents the highest score for that subjective state, and the higher the score, the worse the outcome." (NCT03810703)
Timeframe: End of study (Baseline - time 0 and approximately 4 weeks later)

,,
Interventionscore on a scale (Mean)
FeelLikeDislikeHighMore
Amphetamine 10 mg Arm35.2550.6927.1924.8845.38
Amphetamine 20 mg Arm45.7552.8116.2532.6952.44
Placebo Arm18.8837.4419.0017.5029.19

Reviews

28 reviews available for dextroamphetamine and Chemical Dependence

ArticleYear
Are there any potentially dangerous pharmacological effects of combining ADHD medication with alcohol and drugs of abuse? A systematic review of the literature.
    BMC psychiatry, 2015, Oct-30, Volume: 15

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Alcohol Drinking; Atomoxetine Hydrochloride; Attention Def

2015
Generation Z: Adolescent Xenobiotic Abuse in the 21st Century.
    Adolescent medicine: state of the art reviews, 2015, Volume: 26, Issue:3

    Topics: Adolescent; Amphetamine-Related Disorders; Cannabinoids; Central Nervous System Stimulants; Designer

2015
Lisdexamfetamine: a prodrug stimulant for ADHD.
    Journal of psychosocial nursing and mental health services, 2008, Volume: 46, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Dextroamphetamine; Double-Blind M

2008
Pharmacotherapy of methamphetamine addiction: an update.
    Substance abuse, 2008, Volume: 29, Issue:3

    Topics: Antipsychotic Agents; Aripiprazole; Bupropion; Central Nervous System Stimulants; Dextroamphetamine;

2008
The efficacy and safety profile of lisdexamfetamine dimesylate, a prodrug of d-amphetamine, for the treatment of attention-deficit/hyperactivity disorder in children and adults.
    Clinical therapeutics, 2009, Volume: 31, Issue:1

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clin

2009
Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.
    Annals of the New York Academy of Sciences, 2010, Volume: 1187

    Topics: Animals; Behavior Therapy; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clini

2010
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.
    Biological chemistry, 2011, Volume: 392, Issue:1-2

    Topics: Amphetamines; Animals; Dextroamphetamine; Humans; Methamphetamine; Mitochondria; Molecular Structure

2011
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
    Journal of child psychology and psychiatry, and allied disciplines, 2013, Volume: 54, Issue:3

    Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure

2013
Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.
    The Journal of clinical psychiatry, 2003, Volume: 64 Suppl 11

    Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimula

2003
NTP-CERHR monograph on the potential human reproductive and developmental effects of amphetamines.
    NTP CERHR MON, 2005, Issue:16

    Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Central Nervo

2005
The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse.
    Methods (San Diego, Calif.), 2006, Volume: 39, Issue:3

    Topics: Animals; Behavior, Addictive; Conditioning, Psychological; Dextroamphetamine; Disease Models, Animal

2006
The science of stimulant abuse.
    Pediatric annals, 2006, Volume: 35, Issue:8

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; De

2006
[Memory processes and addiction: involvement of the calcineurin signaling pathway].
    Postepy higieny i medycyny doswiadczalnej (Online), 2007, Volume: 61

    Topics: Animals; Behavior, Addictive; Calcineurin; Dextroamphetamine; Down-Regulation; Hippocampus; Humans;

2007
Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse.
    Biochemical pharmacology, 2008, Jan-01, Volume: 75, Issue:1

    Topics: Animals; Behavior; Central Nervous System Stimulants; Cyclohexanols; Dextroamphetamine; Dopamine; Hu

2008
The pharmacology of khat.
    General pharmacology, 1984, Volume: 15, Issue:3

    Topics: Alkaloids; Animals; Catha; Dextroamphetamine; Female; Humans; Male; Mice; Motor Activity; Phenylprop

1984
Genetic determinants of responses to drugs of abuse: an evaluation of research strategies.
    NIDA research monograph, 1984, Volume: 54

    Topics: Animals; Behavior, Animal; Breeding; Chemical and Drug Induced Liver Injury; Cocaine; Corpus Striatu

1984
Behavioral mechanisms and loci of drug dependence: an overview.
    NIDA research monograph, 1981, Volume: 37

    Topics: Animals; Behavior; Compulsive Behavior; Dextroamphetamine; Disease Models, Animal; Humans; Motivatio

1981
Circuits, drugs, and drug addiction.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Amygdala; Animals; Benzazepines; Brain; Cocaine; Dextroamphetamine; Dopamine; gamma-Aminobutyric Aci

1998
[Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1999, Nov-10, Volume: 119, Issue:27

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dext

1999
Psychostimulants in supportive care.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2000, Volume: 8, Issue:5

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Dextroamphetamine; Ephedrine; Humans; Men

2000
The behavioral effects of phencyclidine in animals.
    NIDA research monograph, 1978, Issue:21

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Drug Interactions; Drug Tolerance; Humans; Motor Activ

1978
Hyperkinetic children: the use of stimulant drugs evaluated.
    The American journal of orthopsychiatry, 1975, Volume: 45, Issue:1

    Topics: Achievement; Animals; Attention; Blood Pressure; Central Nervous System; Dextroamphetamine; Feeding

1975
Effects of psychostimulants on aggression.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Adolescent; Aggression; Amphetamine; Animals; Child; Dextroamphetamine; Dogs; Dose-Response Relation

1975
An experimental analysis of behavioral factors in drug dependence.
    Federation proceedings, 1975, Volume: 34, Issue:9

    Topics: Administration, Oral; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cannabis; Chlorpromazine;

1975
Behavioral and pharmacological determinants of drug abuse.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Animals; Columbidae; Conditioning, Classical; Dextroamphetamine; Electroshock; Feeding Behavior; Hum

1992
Child psychiatry.
    Progress in neurology and psychiatry, 1972, Volume: 27

    Topics: Adolescent; Adoption; Child; Child Abuse; Child Behavior Disorders; Child Development; Child Psychia

1972
Genetic issues in the syndrome of minimal brain dysfunction.
    Seminars in psychiatry, 1973, Volume: 5, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Diseases in Twins; Female; Humans;

1973
Psychedelic drugs and mystical experience.
    International psychiatry clinics, 1969, Volume: 5, Issue:4

    Topics: Cognition; Dextroamphetamine; Esthetics; Hallucinogens; Humans; Lysergic Acid Diethylamide; Mysticis

1969

Trials

31 trials available for dextroamphetamine and Chemical Dependence

ArticleYear
Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.
    Drug and alcohol dependence, 2020, 01-01, Volume: 206

    Topics: Adolescent; Adult; Amygdala; Anticipation, Psychological; Caudate Nucleus; Central Nervous System St

2020
Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.
    Psychopharmacology, 2021, Volume: 238, Issue:10

    Topics: Adult; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Doubl

2021
Validation of a behavioral economic purchase task for assessing drug abuse liability.
    Addiction biology, 2019, Volume: 24, Issue:2

    Topics: Administration, Oral; Central Nervous System Stimulants; Dextroamphetamine; Double-Blind Method; Eco

2019
A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adult; Dextroamphetamine; Dronabinol; Drug Tolerance; Drug Users; Ethanol; Female; Healthy Volunteer

2015
Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:4

    Topics: Central Nervous System Stimulants; Dextroamphetamine; Double-Blind Method; Humans; Injections, Intra

2009
Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:4

    Topics: Administration, Oral; Adult; Blood Pressure; Central Nervous System Stimulants; Dextroamphetamine; D

2009
Stress-induced changes in mood and cortisol release predict mood effects of amphetamine.
    Drug and alcohol dependence, 2010, Jun-01, Volume: 109, Issue:1-3

    Topics: Adolescent; Adult; Affect; Anger; Anxiety; Central Nervous System Stimulants; Dextroamphetamine; Dou

2010
Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users.
    Clinical pharmacology and therapeutics, 2010, Volume: 88, Issue:1

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Atomoxetine Hydrochloride; Attention; Biogenic Mon

2010
The "younger-sibling-at-risk design": a pilot study of adolescents with ADHD and an older sibling with substance use disorder.
    The American journal of drug and alcohol abuse, 2011, Volume: 37, Issue:4

    Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst

2011
Modafinil as a replacement for dextroamphetamine for sustaining alertness in military helicopter pilots.
    Aviation, space, and environmental medicine, 2012, Volume: 83, Issue:6

    Topics: Adult; Aerospace Medicine; Aircraft; Arousal; Benzhydryl Compounds; Central Nervous System Stimulant

2012
Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans.
    Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:4

    Topics: Adult; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Doubl

2004
Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users.
    Psychopharmacology, 2006, Volume: 185, Issue:4

    Topics: Adolescent; Adult; Affect; Arousal; Behavior; Caffeine; Central Nervous System Stimulants; Dextroamp

2006
Bupropion: clinical assay for amphetamine-like abuse potential.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2

    Topics: Adult; Animals; Antidepressive Agents; Appetite; Blood Pressure; Bupropion; Dextroamphetamine; Doubl

1983
A comparison of bupropion, dextroamphetamine, and placebo in mixed-substance abusers.
    Psychopharmacology, 1983, Volume: 80, Issue:3

    Topics: Adult; Antidepressive Agents; Arousal; Blood Pressure; Body Temperature Regulation; Bupropion; Clini

1983
Assessment of dependence potential of drugs in humans using multiple indices.
    Psychopharmacology, 1983, Volume: 81, Issue:2

    Topics: Adult; Dextroamphetamine; Drug Tolerance; Emotions; Female; Humans; Male; Substance-Related Disorder

1983
Drug preference and mood in humans: diazepam.
    Psychopharmacology, 1980, Volume: 71, Issue:3

    Topics: Choice Behavior; Dextroamphetamine; Diazepam; Emotions; Female; Humans; Male; Placebos; Substance-Re

1980
Drug preference and mood in humans: d-amphetamine.
    Psychopharmacology, 1980, Volume: 71, Issue:3

    Topics: Adult; Choice Behavior; Dextroamphetamine; Emotions; Female; Humans; Male; Placebos; Substance-Relat

1980
Drug preference and mood in humans: preference for d-amphetamine and subject characteristics.
    Psychopharmacology, 1981, Volume: 74, Issue:2

    Topics: Adult; Choice Behavior; Dextroamphetamine; Emotions; Humans; Personality; Substance-Related Disorder

1981
Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans.
    Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:2

    Topics: 1-Naphthylamine; Adolescent; Adult; Alprazolam; Arousal; Attention; Attitude; Dextroamphetamine; Dou

1995
Modulation of drug reinforcement by behavioral requirements following drug ingestion.
    Psychopharmacology, 1994, Volume: 114, Issue:2

    Topics: Adult; Arousal; Behavior; Dextroamphetamine; Double-Blind Method; Environment; Humans; Male; Reinfor

1994
Factors influencing the reinforcing and subjective effects of ephedrine in humans.
    Psychopharmacology, 1994, Volume: 113, Issue:3-4

    Topics: Adolescent; Adult; Affect; Dextroamphetamine; Dose-Response Relationship, Drug; Ephedrine; Euphoria;

1994
Laboratory validation study of drug evaluation and classification program: alprazolam, d-amphetamine, codeine, and marijuana.
    Journal of analytical toxicology, 1998, Volume: 22, Issue:6

    Topics: Adult; Alprazolam; Automobile Driving; Codeine; Dextroamphetamine; Double-Blind Method; Dronabinol;

1998
Abuse liability assessment of sibutramine, a novel weight control agent.
    Psychopharmacology, 2000, Volume: 147, Issue:4

    Topics: Adult; Affect; Appetite Depressants; Blood Pressure; Cyclobutanes; Dextroamphetamine; Double-Blind M

2000
Residential laboratory research: a multidimensional evaluation of the effects of drugs on behavior.
    NIDA research monograph, 1990, Volume: 100

    Topics: Adult; Attention; Dextroamphetamine; Feeding Behavior; Humans; Marijuana Smoking; Motivation; Psycho

1990
Reinforcing and subjective effects of several anorectics in normal human volunteers.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: Adult; Affect; Appetite Depressants; Dextroamphetamine; Female; Humans; Male; Substance-Related Diso

1987
Evaluation of mixtures of morphine and d-amphetamine for subjective and physiological effects.
    Drug and alcohol dependence, 1986, Volume: 17, Issue:1

    Topics: Body Temperature; Dextroamphetamine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Int

1986
Dextroamphetamine. Evaluation of psychomimetic properties in man.
    Archives of general psychiatry, 1972, Volume: 26, Issue:2

    Topics: Administration, Oral; Adult; Catecholamines; Central Nervous System; Clinical Trials as Topic; Depre

1972
Comparison of the effects of dexamphetamine and 1-benzylpiperazine in former addicts.
    European journal of clinical pharmacology, 1973, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Amphetamine; Benzyl Compounds; Blood Pressure; Clinical Trials as Topic; Dextroam

1973
Proceedings: Comparison of the effects of dexamphetamine and 1-benzylpiperazine in former addicts.
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Amphetamine; Behavior; Benzyl Compounds; Blood Pressure; Clinical Trials as Topic

1972
Double-blind trial of anorectic agents.
    The Medical journal of Australia, 1969, Feb-22, Volume: 1, Issue:8

    Topics: Adolescent; Adult; Aged; Amphetamine; Appetite Depressants; Clinical Trials as Topic; Dextroamphetam

1969
Amphetamine abuse.
    Science (New York, N.Y.), 1971, Jan-29, Volume: 171, Issue:3969

    Topics: Acetylcholinesterase; Aggression; Amphetamine; Animals; Antisocial Personality Disorder; Behavior, A

1971

Other Studies

127 other studies available for dextroamphetamine and Chemical Dependence

ArticleYear
Confronting the challenge of failed translation in medications development for substance use disorders.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 210

    Topics: Analgesics, Opioid; COVID-19; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Drug Devel

2021
Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.
    Neuropharmacology, 2022, 01-01, Volume: 202

    Topics: Animals; Conditioning, Operant; Dextroamphetamine; Drug Combinations; Female; Humans; Male; Nicotine

2022
QT prolongation by dexamphetamine: Does experience matter?
    Journal of cardiovascular electrophysiology, 2017, Volume: 28, Issue:8

    Topics: Central Nervous System Stimulants; Dextroamphetamine; Electrocardiography; Female; Humans; Long QT S

2017
Enhancement of a visual reinforcer by D-amphetamine and nicotine in adult rats: relation to habituation and food restriction.
    Psychopharmacology, 2018, Volume: 235, Issue:3

    Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Feeding Behavi

2018
Characterization of locomotor response to psychostimulants in the parthenogenetic marbled crayfish (Procambarus fallax forma virginalis): A promising model for studying the neural and molecular mechanisms of drug addiction.
    Behavioural brain research, 2019, 04-01, Volume: 361

    Topics: Animals; Astacoidea; Central Nervous System Stimulants; Dextroamphetamine; Disease Models, Animal; L

2019
Assessment of the abuse liability of ABT-288, a novel histamine H₃ receptor antagonist.
    Psychopharmacology, 2013, Volume: 228, Issue:2

    Topics: Animals; Cocaine; Dextroamphetamine; Discrimination Learning; Drug Administration Schedule; Histamin

2013
Traumatic stress in rats induces noradrenergic-dependent long-term behavioral sensitization: role of individual differences and similarities with dependence on drugs of abuse.
    Psychopharmacology, 2013, Volume: 230, Issue:3

    Topics: Animals; Behavior, Animal; Clonidine; Dextroamphetamine; Hypothalamo-Hypophyseal System; Male; Motor

2013
Relationship between drug discrimination and ratings of subjective effects: implications for assessing and understanding the abuse potential of D-amphetamine in humans.
    Behavioural pharmacology, 2013, Volume: 24, Issue:5-6

    Topics: Analysis of Variance; Area Under Curve; Blood Pressure; Central Nervous System Stimulants; Dextroamp

2013
Relationship between oral D-amphetamine self-administration and ratings of subjective effects: do subjective-effects ratings correspond with a progressive-ratio measure of drug-taking behavior?
    Behavioural pharmacology, 2013, Volume: 24, Issue:5-6

    Topics: Administration, Oral; Adult; Affect; Area Under Curve; Central Nervous System Stimulants; Dextroamph

2013
ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study.
    Addictive behaviors, 2014, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Age Factors; Alcoholism; Attention Deficit Disorder with Hyperactivity; Central N

2014
Patterns of concurrent substance use among adolescent nonmedical ADHD stimulant users.
    Addictive behaviors, 2015, Volume: 49

    Topics: Adolescent; Amphetamines; Analgesics, Opioid; Central Nervous System Stimulants; Child; Cocaine-Rela

2015
Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:4

    Topics: Adult; Behavior, Addictive; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Rela

2016
The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:1

    Topics: Animals; Baclofen; Central Nervous System Stimulants; Conditioning, Psychological; Dextroamphetamine

2009
Case histories in pharmaceutical risk management.
    Drug and alcohol dependence, 2009, Dec-01, Volume: 105 Suppl 1

    Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Dextroamphetamine; Drug and Narcotic Contro

2009
Discriminative stimulus, subject-rated and cardiovascular effects of cocaine alone and in combination with aripiprazole in humans.
    Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:11

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Behavior; Blood Pressure; Cardiovascular System; Central

2011
OPRM1 gene variants modulate amphetamine-induced euphoria in humans.
    Genes, brain, and behavior, 2011, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Alleles; Amphetamine; Blood Pressure; Central Nervous System Stimulants; Chromoso

2011
[The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2012, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo

2012
Dextrose and insulin in addiction.
    Lancet (London, England), 1967, Oct-21, Volume: 2, Issue:7521

    Topics: Alcohol Withdrawal Delirium; Dextroamphetamine; Drug Therapy, Combination; Glucose; Humans; Insulin;

1967
[Abuse potential of sibutramine].
    Medicina clinica, 2003, May-03, Volume: 120, Issue:16

    Topics: Appetite Depressants; Central Nervous System Stimulants; Cyclobutanes; Dextroamphetamine; Female; Hu

2003
Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: two behavioral features of adolescence in mice.
    Behavioral neuroscience, 2003, Volume: 117, Issue:4

    Topics: Adolescent; Adolescent Behavior; Age Factors; Animals; Central Nervous System Stimulants; Conditioni

2003
NEW DRUGS OF ADDICTION?
    British medical journal, 1964, Mar-28, Volume: 1, Issue:5386

    Topics: Adolescent; Amobarbital; Barbiturates; Behavior, Addictive; Dextroamphetamine; Lysergic Acid Diethyl

1964
CONFESSIONS OF A GOOF BALL ADDICT.
    The American journal of psychiatry, 1964, Volume: 120

    Topics: Alcoholism; Amobarbital; Dextroamphetamine; Psychology; Substance-Related Disorders; Toxicology

1964
REACTIONS TO USE OF AMPHETAMINES AS OBSERVED IN A PSYCHIATRIC HOSPITAL.
    New York state journal of medicine, 1964, May-15, Volume: 64

    Topics: Alcoholism; Amobarbital; Amphetamine; Amphetamines; Barbiturates; Dextroamphetamine; Hospitals, Psyc

1964
AMPHETAMINE AND PHENMETRAZINE ADDICTION. PHYSIOLOGICAL ABNORMALITIES IN THE ABSTINENCE SYNDROME.
    British medical journal, 1963, Aug-17, Volume: 2, Issue:5354

    Topics: Amobarbital; Amphetamine; Amphetamines; Behavior, Addictive; Dextroamphetamine; Electroencephalograp

1963
THE NAVAL MEDICAL OFFICER AS A PSYCHIATRIC PATIENT.
    The American journal of psychiatry, 1965, Volume: 122

    Topics: Antisocial Personality Disorder; Dextroamphetamine; Humans; Mental Disorders; Military Personnel; Mi

1965
Reinforcing, subjective, and physiological effects of MDMA in humans: a comparison with d-amphetamine and mCPP.
    Drug and alcohol dependence, 2003, Oct-24, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Affect; Cross-Over Studies; Dextroamphetamine; Dopamine Agonists; Female; Halluci

2003
An update on attention deficit disorder.
    The Harvard mental health letter, 2004, Volume: 20, Issue:11

    Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Ch

2004
Prevalence and characteristics of adolescents patients with co-occurring ADHD and substance dependence.
    Journal of addictive diseases, 2004, Volume: 23, Issue:4

    Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst

2004
D-Amphetamine reinstates behavior previously maintained by food: importance of context.
    Behavioural pharmacology, 2004, Volume: 15, Issue:7

    Topics: Animals; Appetitive Behavior; Central Nervous System Stimulants; Conditioning, Classical; Dextroamph

2004
Preexposure to MDMA ("Ecstasy") delays acquisition but facilitates MDMA-induced reinstatement of amphetamine self-administration behavior in rats.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 79, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Dextroamphetamine; Drug Interactions; Extinction, Psychological; H

2004
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy

2005
Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey.
    Addiction (Abingdon, England), 2005, Volume: 100, Issue:1

    Topics: Adult; Amphetamines; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Met

2005
The reinforcing effects of chronic D-amphetamine and morphine are impaired in a line of memory-deficient mice overexpressing calcineurin.
    The European journal of neuroscience, 2005, Volume: 21, Issue:11

    Topics: Animals; Calcineurin; Conditioning, Psychological; Dextroamphetamine; Drug Administration Schedule;

2005
A comparison of drug-seeking behavior maintained by D-amphetamine, L-deprenyl (selegiline), and D-deprenyl under a second-order schedule in squirrel monkeys.
    Psychopharmacology, 2006, Volume: 183, Issue:4

    Topics: Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response

2006
A low dose of aripiprazole attenuates the subject-rated effects of d-amphetamine.
    Drug and alcohol dependence, 2006, Sep-15, Volume: 84, Issue:2

    Topics: Adult; Antipsychotic Agents; Aripiprazole; Blood Pressure; Central Nervous System Stimulants; Dextro

2006
Identification of an excitatory amino acid-mediated component of the ventral tegmental area local field potential response to medial prefrontal cortex stimulation: effect of acute d-amphetamine.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:2

    Topics: Animals; Central Nervous System Stimulants; Dextroamphetamine; Electric Stimulation; Excitatory Amin

2007
Drug reward and intake in lines of mice selectively bred for divergent exploration of a hole board apparatus.
    Genes, brain, and behavior, 2007, Volume: 6, Issue:7

    Topics: Administration, Oral; Amphetamine-Related Disorders; Animals; Central Nervous System Depressants; Ce

2007
Effects of d-amphetamine and buprenorphine combinations on speedball (cocaine+heroin) self-administration by rhesus monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:9

    Topics: Animals; Behavior, Animal; Buprenorphine; Central Nervous System Stimulants; Cocaine; Dextroamphetam

2007
Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Central Nervous System Stimulants; Com

2007
Lisdexamfetamine dimesylate.
    Nature reviews. Drug discovery, 2007, Volume: 6, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dextroamphe

2007
The nonmedical use of prescription ADHD medications: results from a national Internet panel.
    Substance abuse treatment, prevention, and policy, 2007, Oct-31, Volume: 2

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Appetite Depressants; Attention Defici

2007
The effect of stimulant treatment for ADHD on later substance abuse and the potential for medication misuse, abuse, and diversion.
    The Journal of clinical psychiatry, 2007, Volume: 68, Issue:11

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stim

2007
Cross self-administration of delta 9-tetrahydrocannabinol and D-amphetamine in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1981, Volume: 14, Issue:6

    Topics: Animals; Dextroamphetamine; Dronabinol; Injections, Intravenous; Male; Rats; Rats, Wistar; Reinforce

1981
The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions.
    Brain research, 1984, Jun-11, Volume: 303, Issue:1

    Topics: 5,7-Dihydroxytryptamine; Animals; Cyproheptadine; Dextroamphetamine; Fluoxetine; Humans; Male; Media

1984
Stimulant medication and the hyperactive adolescent: myths and facts.
    Adolescence, 1983,Winter, Volume: 18, Issue:72

    Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Dose-Respon

1983
Drug history modifies the behavioral effects of pentobarbital.
    Science (New York, N.Y.), 1983, Apr-15, Volume: 220, Issue:4594

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; H

1983
Oral d-amphetamine and ketamine self-administration by rhesus monkeys: effects of food deprivation.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:1

    Topics: Animals; Dextroamphetamine; Food Deprivation; Humans; Ketamine; Macaca mulatta; Male; Phencyclidine;

1983
[Effects of lesions of the anterior raphe nuclei on the self-administration of d-amphetamine in the rat : considerable increase of desire for the poison].
    Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles, 1980, Jan-21, Volume: 290, Issue:3

    Topics: Animals; Brain Stem; Dextroamphetamine; Humans; Male; Raphe Nuclei; Rats; Self Administration; Subst

1980
Responding maintained by cocaine or d-amphetamine under fixed-interval schedules in baboons.
    Drug and alcohol dependence, 1980, Volume: 5, Issue:5

    Topics: Animals; Behavior, Animal; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Admini

1980
Chronic amphetamine: effects on defensive flight in the rat.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Aggression; Animals; Dextroamphetamine; Escape Reaction; Humans; Male; Motor Activity; Rats; Substan

1982
Drug preferences in humans.
    Federation proceedings, 1982, Volume: 41, Issue:2

    Topics: Adult; Arousal; Dextroamphetamine; Diazepam; Emotions; Fenfluramine; Humans; Reinforcement, Psycholo

1982
Cocaine self-administration in humans.
    Federation proceedings, 1982, Volume: 41, Issue:2

    Topics: Adult; Blood Pressure; Body Temperature; Cocaine; Dextroamphetamine; Emotions; Heart Rate; Humans; R

1982
Intracranial hemorrhage associated with amphetamine use.
    Neurology, 1981, Volume: 31, Issue:7

    Topics: Adolescent; Amphetamine; Cerebral Hemorrhage; Dextroamphetamine; Humans; Male; Substance-Related Dis

1981
Intracranial hemorrhage with amphetamine abuse.
    Neurology, 1981, Volume: 31, Issue:8

    Topics: Adult; Cerebral Hemorrhage; Dextroamphetamine; Humans; Male; Methylphenidate; Substance-Related Diso

1981
Conditioned dopaminergic activity.
    Biological psychiatry, 1982, Volume: 17, Issue:2

    Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Conditioning, Classical; Cues; Dextroamphet

1982
Self-administration of the endogenous trace amines beta-phenylethylamine, N-methyl phenylethylamine and phenylethanolamine in dogs.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1

    Topics: 2-Hydroxyphenethylamine; Animals; Biogenic Amines; Cocaine; Conditioning, Operant; Dextroamphetamine

1982
Human d-amphetamine drug discrimination: methamphetamine and hydromorphone.
    Journal of the experimental analysis of behavior, 1994, Volume: 61, Issue:2

    Topics: Adult; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Hydromo

1994
Evaluation of the abuse liability of aminorex.
    Drug and alcohol dependence, 1994, Volume: 36, Issue:3

    Topics: Aminorex; Animals; Arousal; Dextroamphetamine; Discrimination Learning; Female; Infusions, Intraveno

1994
Dissimilar patterns of degeneration in brain following four different addictive stimulants.
    Neuroreport, 1993, Oct-25, Volume: 5, Issue:1

    Topics: Animals; Brain; Cocaine; Dextroamphetamine; Disease Models, Animal; Drug Implants; Methamphetamine;

1993
Antagonism of cocaine self-administration by the preferential dopamine autoreceptor antagonist, (+)-AJ 76.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Animals; Cocaine; Conditioning, Operant; Dextroamphetamine; Dopamine Antagonists; Dose-Response Rela

1993
Medication for attention-deficit hyperactivity disorder: balancing art and science.
    Southern medical journal, 1996, Volume: 89, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Agents; Depression

1996
Acquisition of i.v. amphetamine and cocaine self-administration in rats as a function of dose.
    Psychopharmacology, 1997, Volume: 129, Issue:3

    Topics: Animals; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Infusions, Intravenous; Male;

1997
Progress report from the testing program for stimulant and depressant drugs (1996).
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Central Nervous System Depressants; Central Nervous System Stimulants; Dextroamphetamine; D

1998
The development of addiction to d-amphetamine in an animal model: same principles as for alcohol and opiate.
    Psychopharmacology, 1998, Volume: 140, Issue:4

    Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Central Nervous System Stimulants; De

1998
Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Nov-01, Volume: 20, Issue:21

    Topics: Animals; Blotting, Western; Borna Disease; Borna disease virus; Brain; Brain Chemistry; Central Nerv

2000
Changes in dopamine efflux associated with extinction, CS-induced and d-amphetamine-induced reinstatement of drug-seeking behavior by rats.
    Behavioural brain research, 2001, Volume: 120, Issue:2

    Topics: Animals; Conditioning, Operant; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Electrochem

2001
The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered.
    Behavioural pharmacology, 2001, Volume: 12, Issue:1

    Topics: Animals; Cocaine; Conditioning, Operant; Dextroamphetamine; Discrimination, Psychological; Dopamine

2001
Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Apr-01, Volume: 22, Issue:7

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Brain; Central Nervous System

2002
Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.
    Biological psychiatry, 1978, Volume: 13, Issue:2

    Topics: Animals; Appetite; Appetite Depressants; Chlorphentermine; Cocaine; Dextroamphetamine; Diethylpropio

1978
Therapeutic self-medication as a context for drug abuse research.
    NIDA research monograph, 1978, Issue:20

    Topics: Adult; Body Weight; Dextroamphetamine; Drug Prescriptions; Female; Fenfluramine; Humans; Male; Metha

1978
Drug self-administration in humans.
    NIDA research monograph, 1978, Issue:20

    Topics: Adult; Arousal; Dextroamphetamine; Diazepam; Diethylpropion; Emotions; Female; Humans; Male; Placebo

1978
The discriminative properties of amphetamine analogues tested in self-administering rats under maintained stimulus control.
    Addictive behaviors, 1977, Volume: 2, Issue:1

    Topics: Amphetamines; Animals; Conditioning, Operant; Dextroamphetamine; Diethylpropion; Discrimination, Psy

1977
Dopamine receptors hypersensitivity: further confirmation following drug abuse model.
    Advances in experimental medicine and biology, 1977, Volume: 90

    Topics: Amphetamine; Amphetamines; Animals; Dextroamphetamine; Disease Models, Animal; Drug Administration S

1977
Rat dopamine hypersensitivity. I. Effect of age.
    Neuropsychobiology, 1979, Volume: 5, Issue:4

    Topics: Age Factors; Animals; Dextroamphetamine; Drug Hypersensitivity; Humans; Male; Rats; Receptors, Dopam

1979
Rat dopaminergic hypersensitivity. II. Effects of sex.
    Neuropsychobiology, 1979, Volume: 5, Issue:4

    Topics: Animals; Apomorphine; Dextroamphetamine; Drug Hypersensitivity; Female; Humans; Male; Rats; Receptor

1979
Increased sensitivity to (+)amphetamine self-administered by rats following meso-cortico-limbic dopamine neurone destruction.
    Nature, 1979, Jul-12, Volume: 280, Issue:5718

    Topics: Animals; Dextroamphetamine; Dopamine; Humans; Male; Neurons; Rats; Receptors, Dopamine; Self Adminis

1979
The prediction of neuropsychological impairment in polydrug abusers.
    Addictive behaviors, 1978, Volume: 3, Issue:1

    Topics: Adult; Alcoholism; Cannabis; Dextroamphetamine; Humans; Illicit Drugs; Life Style; Mental Disorders;

1978
Intragastric self-administration of psychoactive drugs by the rhesus monkey.
    Life sciences, 1975, Sep-15, Volume: 17, Issue:6

    Topics: Animals; Dextroamphetamine; Disease Models, Animal; Ethanol; Haplorhini; Humans; Macaca mulatta; Met

1975
Drug abuse proficiency testing.
    Clinical toxicology, 1977, Volume: 10, Issue:2

    Topics: Barbiturates; Cocaine; Dextroamphetamine; False Negative Reactions; Humans; Illicit Drugs; Laborator

1977
Hemodynamic effects of intra-arterial injection of drugs of abuse.
    Surgery, 1976, Volume: 79, Issue:4

    Topics: Animals; Blood Flow Velocity; Dextroamphetamine; Dextropropoxyphene; Dose-Response Relationship, Dru

1976
Rate dependent drug effects: possible state dependency.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 4, Issue:2

    Topics: Animals; Conditioning, Classical; Dextroamphetamine; Humans; Male; Rats; Reinforcement Schedule; Sub

1976
Electromyographic biofeedback for relief of tension in the facial and throat muscles of a woodwind musician.
    Biofeedback and self-regulation, 1976, Volume: 1, Issue:1

    Topics: Adult; Alcoholism; Biofeedback, Psychology; Dextroamphetamine; Electromyography; Facial Muscles; Hum

1976
Abuse of stimulant drugs in Nigeria.
    The British journal of addiction to alcohol and other drugs, 1976, Volume: 71, Issue:1

    Topics: Adolescent; Adult; Anxiety; Caffeine; Dextroamphetamine; Drug Synergism; Female; Humans; Male; Niger

1976
Perinatal narcotic addiction in mice: sensitization to morphine stimulation.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Age Factors; Animals; Animals, Newborn; Cocaine; Cycloheximide; Dextroamphetamine; Dextrorphan; Dose

1975
Effects of drug experience on drug induced conditioned taste aversions: studies with amphetamine and fenfluramine.
    Psychopharmacologia, 1975, Oct-14, Volume: 44, Issue:1

    Topics: Animals; Avoidance Learning; Body Weight; Choice Behavior; Conditioning, Psychological; Dextroamphet

1975
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity

1992
Methods for the assessment of abuse liability of psychomotor stimulants and anorectic agents in humans.
    British journal of addiction, 1991, Volume: 86, Issue:12

    Topics: Appetite Depressants; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationsh

1991
Dexamphetamine for "speed" addiction.
    The Medical journal of Australia, 1990, Sep-03, Volume: 153, Issue:5

    Topics: Adult; Dextroamphetamine; Female; Humans; Male; Methamphetamine; Substance-Related Disorders

1990
Human d-amphetamine drug discrimination: testing with d-amphetamine and hydromorphone.
    NIDA research monograph, 1989, Volume: 95

    Topics: Adult; Arousal; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Humans

1989
Narcolepsy, paranoid psychosis, and analeptic abuse.
    Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa, 1989, Volume: 14, Issue:3

    Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Methylphenidate; Middle Ag

1989
Factors that predict individual vulnerability to amphetamine self-administration.
    Science (New York, N.Y.), 1989, Sep-29, Volume: 245, Issue:4925

    Topics: Animals; Dextroamphetamine; Male; Motor Activity; Rats; Rats, Inbred Strains; Risk Factors; Self Adm

1989
Discriminative stimulus properties of intragastrically administered d-amphetamine and pentobarbital in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Bupropion; Dextroamphetamine; Discrimination Lea

1987
A comparative assay of nefopam, morphine and d-amphetamine.
    Psychopharmacology, 1987, Volume: 91, Issue:3

    Topics: Behavior; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Morphine; Nefopam; Oxaz

1987
The reinforcing properties of amphetamine in overweight subjects and subjects with depression.
    Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:2

    Topics: Adult; Affect; Choice Behavior; Depression; Dextroamphetamine; Female; Humans; Male; Obesity; Person

1987
Anorectics: effects on food intake and self-administration in rhesus monkeys.
    Alcohol and drug research, 1987, Volume: 7, Issue:5-6

    Topics: Animals; Appetite Depressants; Dextroamphetamine; Eating; Female; Macaca mulatta; Male; Reinforcemen

1987
The effects of food deprivation on the self-administration of psychoactive drugs.
    Drug and alcohol dependence, 1987, Volume: 19, Issue:1

    Topics: Animals; Cocaine; Dextroamphetamine; Diazepam; Food Deprivation; Macaca mulatta; Male; Nicotine; Per

1987
Psychosocial aspects of AIDS.
    British journal of hospital medicine, 1987, Volume: 37, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Attitude to Health; Brain Diseases; Child; Dementia; Dextroamphe

1987
Brain-stimulation reward: a model for the neuronal bases for drug-induced euphoria.
    NIDA research monograph, 1985, Volume: 62

    Topics: Animals; Brain; Cocaine; Dextroamphetamine; Electric Stimulation; Euphoria; Humans; Models, Neurolog

1985
[Behavioral changes in rhesus monkeys induced by repeated administration of ephedrine].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1985, Volume: 87, Issue:8

    Topics: Animals; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Ephedrine; Humans; Macaca mula

1985
Methaqualone overdose: analytical methodology, and the significance of serum drug concentrations.
    Clinical chemistry, 1973, Volume: 19, Issue:6

    Topics: Alcohol Drinking; Alkanes; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Consciousnes

1973
Heroin and cocaine addiction.
    Lancet (London, England), 1965, Apr-10, Volume: 1, Issue:7389

    Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Dextroamphetamine; Ethanol; Female;

1965
The nasal drop addict.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Apr-19, Volume: 43, Issue:16

    Topics: Cautery; Chlorpheniramine; Dextroamphetamine; Humans; Methylprednisolone; Nasal Decongestants; Rhini

1969
A comparison of chlorpromazine, imipramine, morphine and d-amphetamine self-administration in cocaine-dependent rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1

    Topics: Animals; Behavior, Animal; Chlorpromazine; Cocaine; Dextroamphetamine; Dose-Response Relationship, D

1973
Self-administration of d-amphetamine, morphine and chlorpromazine by cocaine "dependent" rhesus monkeys.
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Animals; Behavior, Animal; Chlorpromazine; Cocaine; Conditioning, Operant; Dextroamphetamine; Extinc

1970
Discussion of case-control study of Hodgkin's disease.
    Cancer research, 1974, Volume: 34, Issue:5

    Topics: Amphetamine; Antigens, Viral; Dextroamphetamine; Epidemiologic Methods; Genotype; Herpesvirus 4, Hum

1974
Management of micro-emboli of the digital arteries.
    Le Journal medical libanais. The Lebanese medical journal, 1974, Volume: 27, Issue:4

    Topics: Adult; Angiography; Arteries; Catheterization; Dextrans; Dextroamphetamine; Embolism; Fingers; Hepar

1974
Symposium: behavior modification by drugs. 3. The clinical use of stimulant drugs in children.
    Pediatrics, 1972, Volume: 49, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Feeding and Eat

1972
The effects of low-dose combinations of D-amphetamine and cocaine on experimentally induced conflict in the rat.
    Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:4

    Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Psychological; Conflict, Psychological; Dextroamph

1972
Alpha-methyltyrosine to prevent self-administration of morphine and amphetamine.
    Current therapeutic research, clinical and experimental, 1972, Volume: 14, Issue:12

    Topics: Animals; Conditioning, Operant; Dextroamphetamine; Humans; Male; Methyltyrosines; Morphine; Morphine

1972
Amphetamine-type drugs for hyperactive children.
    The Medical letter on drugs and therapeutics, 1972, Mar-31, Volume: 14, Issue:7

    Topics: Appetite; Attention Deficit Disorder with Hyperactivity; Body Weight; Brain; Child; Dextroamphetamin

1972
Hyperactive children.
    British medical journal, 1973, Mar-10, Volume: 1, Issue:5853

    Topics: Brain; Child; Dextroamphetamine; Humans; Hyperkinesis; Methylphenidate; Substance-Related Disorders

1973
Separation and quantitation of mixtures of the most commonly abused drugs.
    Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:1

    Topics: Amobarbital; Cannabis; Chromatography, Thin Layer; Dextroamphetamine; Ephedrine; Humans; Indicators

1973
The effects of drugs on learning and memory. A review of the literature.
    The International journal of the addictions, 1973, Volume: 8, Issue:4

    Topics: Aged; Amphetamine; Animals; Cannabis; Child; Chlorpromazine; Dextroamphetamine; Female; Hallucinogen

1973
The metabolism of amphetamine in dependent subjects.
    European journal of clinical pharmacology, 1973, Volume: 6, Issue:3

    Topics: Biodegradation, Environmental; Carbon Radioisotopes; Chromatography, Paper; Dextroamphetamine; Femal

1973
Letter: Pathophysiology of depressive syndromes.
    Biological psychiatry, 1974, Volume: 8, Issue:1

    Topics: Amphetamine; Depression; Dextroamphetamine; Humans; Monoamine Oxidase Inhibitors; Phenethylamines; S

1974
Reduced threshold to pain induced aggression specifically related to morphine dependence.
    Psychopharmacologia, 1974, Feb-27, Volume: 35, Issue:3

    Topics: Aggression; Animals; Dextroamphetamine; Drug Synergism; Electroshock; Ethanol; Humans; Male; Morphin

1974
Self-administration of psychoactive substances by the monkey.
    Psychopharmacologia, 1969, Volume: 16, Issue:1

    Topics: Animals; Behavior, Animal; Caffeine; Catheterization; Chlorpromazine; Cocaine; Codeine; Dextroamphet

1969
Addiction to Daprisal.
    Southern medical journal, 1972, Volume: 65, Issue:2

    Topics: Adult; Amobarbital; Aspirin; Depression; Dextroamphetamine; Drug Combinations; Female; Humans; Male;

1972
Physician characteristics and attitudes toward legitimate use of psychotherapeutic drugs.
    Journal of health and social behavior, 1971, Volume: 12, Issue:2

    Topics: Adult; Aged; Attitude; Chlordiazepoxide; Dextroamphetamine; Drug Prescriptions; Ethics, Medical; Fam

1971
Improved colorimetric method for assay of amphetamines in urine.
    Clinical chemistry, 1971, Volume: 17, Issue:10

    Topics: Alkaloids; Amphetamine; Azo Compounds; Chemical Phenomena; Chemistry; Chemistry, Clinical; Chlorofor

1971
Lilliputian hallucinatiion complicatign dexamphetamine-amylobarbitone addiction.
    The British journal of addiction to alcohol and other drugs, 1968, Volume: 63, Issue:3

    Topics: Adolescent; Adult; Barbiturates; Dextroamphetamine; Humans; Introversion, Psychological; Male; Psych

1968
Effect of D-amphetamine on menstruation.
    American journal of obstetrics and gynecology, 1969, Nov-15, Volume: 105, Issue:6

    Topics: Animals; Dextroamphetamine; Female; Humans; Menstruation; Substance-Related Disorders

1969
Amphetamine taking among young offenders.
    The British journal of psychiatry : the journal of mental science, 1970, Volume: 116, Issue:532

    Topics: Adolescent; Amphetamine; Dextroamphetamine; England; Humans; Juvenile Delinquency; Male; Substance-R

1970
Critical incidents in the context of family therapy. Critical incident no. 6.
    International psychiatry clinics, 1970, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Child; Conflict, Psychological; Depression; Dextroamphetamine; Family Therapy; Fe

1970
Intracranial hemorrhage associated with amphetamine abuse.
    JAMA, 1970, Apr-20, Volume: 212, Issue:3

    Topics: Adolescent; Adult; Amphetamine; Cerebral Hemorrhage; Dextroamphetamine; Humans; Male; Substance-Rela

1970
The epidemiology of drug overdosage.
    The Medical journal of Australia, 1970, Aug-15, Volume: 2, Issue:7

    Topics: Amphetamine; Aspirin; Caffeine; Dextroamphetamine; Drug and Narcotic Control; Female; Humans; Substa

1970
Addiction to daprisal.
    JAMA, 1968, Sep-23, Volume: 205, Issue:13

    Topics: Adult; Amobarbital; Analgesics; Aspirin; Depression; Dextroamphetamine; Humans; Phenacetin; Substanc

1968