dextroamphetamine has been researched along with Bipolar Disorder in 73 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Lisdexamfetamine dimesylate offered beneficial effects on body weight, body mass index and several metabolic parameters." | 9.17 | The effect of lisdexamfetamine dimesylate on body weight, metabolic parameters, and attention deficit hyperactivity disorder symptomatology in adults with bipolar I/II disorder. ( Almagor, D; Alsuwaidan, M; Bilkey, TS; Cha, DS; Gallaugher, LA; Kennedy, SH; McIntyre, RS; Powell, AM; Soczynska, JK; Szpindel, I; Woldeyohannes, HO, 2013) |
| " This study examines the effects of chronic lithium administration on changes induced by amphetamine administration and withdrawal on open field locomotor activity of rats, and considered as an animal model of behaviors displayed in bipolar disorders." | 7.68 | Effects of lithium on an amphetamine animal model of bipolar disorder. ( Cappeliez, P; Moore, E, 1990) |
| "Therefore, LIRA can reverse some mania-like behavioral alterations and combined with Li augmented the mood stabilizing and neuroprotective properties of Li." | 5.56 | The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. ( Barichello, T; Chaves Filho, AJM; Cunha, NL; de Lucena, D; de Queiroz, T; de Souza, AG; Jucá, PM; Macedo, DS; Oliveira, JVS; Quevedo, J; Soares, MV; Valvassori, SS, 2020) |
| " Lisdexamfetamine dimesylate offered beneficial effects on body weight, body mass index and several metabolic parameters." | 5.17 | The effect of lisdexamfetamine dimesylate on body weight, metabolic parameters, and attention deficit hyperactivity disorder symptomatology in adults with bipolar I/II disorder. ( Almagor, D; Alsuwaidan, M; Bilkey, TS; Cha, DS; Gallaugher, LA; Kennedy, SH; McIntyre, RS; Powell, AM; Soczynska, JK; Szpindel, I; Woldeyohannes, HO, 2013) |
| "The use of traditional psychostimulants (methylphenidate and dexamphetamine) and stimulant-like drugs (modafinil and armodafinil) for the treatment of depression is a growing concern given the lack of research evidence supporting their effectiveness." | 4.93 | Stimulants for depression: On the up and up? ( Bassett, D; Boyce, P; Byrow, Y; Hopwood, M; Lyndon, W; Malhi, GS; Mulder, R; Murray, G; Porter, R; Singh, A, 2016) |
| " Since protein kinase C (PKC) activity has been implicated in the pathophysiology of bipolar disorder and the biochemical effects of mood stabilizers, the new PKC inhibitor myricitrin (10, 30 mg/kg) was also evaluated." | 3.80 | Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania? ( Andreatini, R; Brenes, JC; Pereira, M; Schwarting, RK, 2014) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| " This study examines the effects of chronic lithium administration on changes induced by amphetamine administration and withdrawal on open field locomotor activity of rats, and considered as an animal model of behaviors displayed in bipolar disorders." | 3.68 | Effects of lithium on an amphetamine animal model of bipolar disorder. ( Cappeliez, P; Moore, E, 1990) |
| "d-Amphetamine was 2 to 2." | 2.64 | Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. ( Murphy, DL; Van Kammen, DP, 1975) |
| "Therefore, LIRA can reverse some mania-like behavioral alterations and combined with Li augmented the mood stabilizing and neuroprotective properties of Li." | 1.56 | The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. ( Barichello, T; Chaves Filho, AJM; Cunha, NL; de Lucena, D; de Queiroz, T; de Souza, AG; Jucá, PM; Macedo, DS; Oliveira, JVS; Quevedo, J; Soares, MV; Valvassori, SS, 2020) |
| " CD-1 mice were subcutaneously dosed for 5 days with 1." | 1.42 | Amphetamine sensitization in mice is sufficient to produce both manic- and depressive-related behaviors as well as changes in the functional connectivity of corticolimbic structures. ( Baker, K; Ibrahim, BA; Kelly, MP; McCarthy, SA; Pathak, G, 2015) |
| " Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities." | 1.42 | Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. ( Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L, 2015) |
| "Lisdexamfetamine dimesylate (LDX) is a prodrug that requires conversion to d-amphetamine (d-AMPH) for bioactivity." | 1.39 | Effects of lithium on oxidative stress and behavioral alterations induced by lisdexamfetamine dimesylate: relevance as an animal model of mania. ( Araújo, MM; Carvalho, AF; Cordeiro, RC; de Lucena, DF; Hyphantis, TN; Macêdo, DS; McIntyre, RS; Queiroz, AI; Quevedo, J; Sousa, FC; Vasconcelos, SM, 2013) |
| "Haloperidol pretreatment in one pair of twins abolished the excitation response but did not reduce increases in cortisol and growth hormone." | 1.26 | Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients. ( Brown, GM; Dibble, ED; Ebert, M; Gershon, ES; Gold, P; Guroff, JJ; Jimerson, DC; Jimerson, SS; Kessler, LR; Nurnberger, JI; Simmons, S; Storch, FI, 1982) |
| "Depression is an important cause of behavioral disturbances in children." | 1.26 | Childhood depression: an explanation of a behavior disorder of children. ( Brumback, RA; Weinberg, WA, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (30.14) | 18.7374 |
| 1990's | 7 (9.59) | 18.2507 |
| 2000's | 9 (12.33) | 29.6817 |
| 2010's | 32 (43.84) | 24.3611 |
| 2020's | 3 (4.11) | 2.80 |
| Authors | Studies |
|---|---|
| Valvassori, SS | 15 |
| Tonin, PT | 3 |
| Dal-Pont, GC | 4 |
| Varela, RB | 9 |
| Cararo, JH | 1 |
| Garcia, AF | 1 |
| Gava, FF | 3 |
| Menegas, S | 1 |
| Soares, JC | 2 |
| Quevedo, J | 19 |
| Tran, HQ | 1 |
| Shin, EJ | 1 |
| Saito, K | 1 |
| Tran, TV | 1 |
| Phan, DH | 1 |
| Sharma, N | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Jeong, JH | 1 |
| Jang, CG | 1 |
| Cheong, JH | 1 |
| Nabeshima, T | 1 |
| Kim, HC | 1 |
| Chaves Filho, AJM | 2 |
| Cunha, NL | 2 |
| de Souza, AG | 2 |
| Soares, MV | 2 |
| Jucá, PM | 2 |
| de Queiroz, T | 2 |
| Oliveira, JVS | 1 |
| Barichello, T | 1 |
| de Lucena, D | 1 |
| Macedo, DS | 4 |
| Rodrigues, PA | 1 |
| Clemente, DCDS | 1 |
| Mottin, M | 1 |
| Andrade, CH | 1 |
| Peixoto, CA | 1 |
| Mariot, E | 2 |
| Bavaresco, DV | 1 |
| Ferreira, CL | 4 |
| Andersen, ML | 5 |
| Tye, SJ | 1 |
| Parker, G | 2 |
| Brotchie, H | 2 |
| McClure, G | 1 |
| Fletcher, K | 1 |
| McIntyre, RS | 3 |
| Alsuwaidan, M | 1 |
| Soczynska, JK | 1 |
| Szpindel, I | 1 |
| Bilkey, TS | 1 |
| Almagor, D | 1 |
| Woldeyohannes, HO | 1 |
| Powell, AM | 1 |
| Cha, DS | 1 |
| Gallaugher, LA | 1 |
| Kennedy, SH | 1 |
| Pereira, M | 1 |
| Andreatini, R | 1 |
| Schwarting, RK | 1 |
| Brenes, JC | 1 |
| Hart, AB | 1 |
| Gamazon, ER | 1 |
| Engelhardt, BE | 1 |
| Sklar, P | 1 |
| Kähler, AK | 1 |
| Hultman, CM | 1 |
| Sullivan, PF | 1 |
| Neale, BM | 1 |
| Faraone, SV | 1 |
| de Wit, H | 1 |
| Cox, NJ | 1 |
| Palmer, AA | 1 |
| Rygula, R | 1 |
| Szczech, E | 1 |
| Kregiel, J | 1 |
| Golebiowska, J | 1 |
| Kubik, J | 1 |
| Popik, P | 1 |
| McElroy, SL | 1 |
| Martens, BE | 1 |
| Mori, N | 1 |
| Blom, TJ | 1 |
| Casuto, LS | 1 |
| Hawkins, JM | 1 |
| Keck, PE | 2 |
| Gubert, C | 1 |
| Fries, GR | 2 |
| Pfaffenseller, B | 1 |
| Ferrari, P | 1 |
| Coutinho-Silva, R | 1 |
| Morrone, FB | 1 |
| Kapczinski, F | 10 |
| Battastini, AMO | 1 |
| Carvalho, AF | 4 |
| Amboni, RT | 1 |
| Bianchini, G | 1 |
| Pathak, G | 1 |
| Ibrahim, BA | 1 |
| McCarthy, SA | 1 |
| Baker, K | 1 |
| Kelly, MP | 1 |
| Zhou, R | 1 |
| Lu, Y | 1 |
| Han, Y | 1 |
| Li, X | 1 |
| Lou, H | 1 |
| Zhu, L | 1 |
| Zhen, X | 1 |
| Duan, S | 1 |
| Minassian, A | 2 |
| Young, JW | 2 |
| Cope, ZA | 1 |
| Henry, BL | 1 |
| Geyer, MA | 2 |
| Perry, W | 2 |
| Malhi, GS | 1 |
| Byrow, Y | 1 |
| Bassett, D | 1 |
| Boyce, P | 1 |
| Hopwood, M | 1 |
| Lyndon, W | 1 |
| Mulder, R | 1 |
| Porter, R | 1 |
| Singh, A | 1 |
| Murray, G | 1 |
| Mattingly, GW | 1 |
| Anderson, RH | 1 |
| Resende, WR | 3 |
| Arent, CO | 3 |
| Peterle, BR | 1 |
| Goey, AK | 1 |
| Paulus, MP | 1 |
| Mavrikaki, M | 1 |
| Nomikos, GG | 1 |
| Panagis, G | 1 |
| Rezin, GT | 1 |
| Moretti, M | 3 |
| Gonçalves, CL | 1 |
| Cardoso, MR | 1 |
| Streck, EL | 3 |
| Steckert, AV | 3 |
| Rochi, N | 2 |
| Benedet, J | 2 |
| Scaini, G | 2 |
| Zugno, AI | 3 |
| Dean, OM | 1 |
| van den Buuse, M | 1 |
| Berk, M | 1 |
| Copolov, DL | 1 |
| Mavros, C | 1 |
| Bush, AI | 1 |
| Pinheiro, RM | 1 |
| de Lima, MN | 1 |
| Garcia, VA | 1 |
| Presti-Torres, J | 1 |
| Hallmenschlager, LH | 1 |
| Alcalde, LA | 1 |
| Roesler, R | 2 |
| Schröder, N | 1 |
| Mina, F | 1 |
| Lopes-Borges, J | 2 |
| Dal-Pizzol, F | 4 |
| Kristensen, LV | 1 |
| Sandager-Nielsen, K | 1 |
| Hansen, HH | 1 |
| Medeiros, CD | 1 |
| Cordeiro, RC | 2 |
| Sousa, FC | 2 |
| Santos, JV | 1 |
| Morais, TA | 1 |
| Hyphantis, TN | 2 |
| Cechinel-Recco, K | 1 |
| Vitto, MF | 1 |
| Luz, G | 1 |
| de Souza, CT | 1 |
| Abrial, E | 1 |
| Etievant, A | 1 |
| Bétry, C | 1 |
| Scarna, H | 1 |
| Lucas, G | 1 |
| Haddjeri, N | 1 |
| Lambás-Señas, L | 1 |
| Fraga, DB | 1 |
| de Lucena, DF | 1 |
| Queiroz, AI | 1 |
| Araújo, MM | 1 |
| Vasconcelos, SM | 1 |
| Asghar, SJ | 3 |
| Tanay, VA | 1 |
| Baker, GB | 1 |
| Greenshaw, A | 1 |
| Silverstone, PH | 5 |
| O'Donnell, T | 1 |
| Ulrich, M | 1 |
| Hanstock, CC | 1 |
| Arban, R | 1 |
| Maraia, G | 1 |
| Brackenborough, K | 1 |
| Winyard, L | 1 |
| Wilson, A | 1 |
| Gerrard, P | 1 |
| Large, C | 1 |
| Benjamin, E | 1 |
| Salek, S | 1 |
| Willson, MC | 1 |
| Bell, EC | 1 |
| Dave, S | 1 |
| McGrath, BM | 1 |
| Frey, BN | 2 |
| Martins, MR | 3 |
| Petronilho, FC | 3 |
| Réus, GZ | 2 |
| Bardini, K | 1 |
| Kauer-Sant'Anna, M | 1 |
| Andreazza, AC | 1 |
| Barbosa, LM | 1 |
| Schwartsmann, G | 1 |
| Oliveira, VB | 1 |
| Boeck, CR | 1 |
| Schwartz, JM | 1 |
| Ksir, C | 1 |
| Koob, GF | 1 |
| Bloom, FE | 1 |
| Belmaker, RH | 1 |
| Lerer, B | 1 |
| Klein, E | 1 |
| Newman, M | 1 |
| Dick, E | 1 |
| Ostrow, DG | 1 |
| Okonek, A | 1 |
| Gibbons, R | 1 |
| Cooper, R | 1 |
| Davis, JM | 2 |
| Reiss, AL | 1 |
| O'Donnell, DJ | 1 |
| Nurnberger, JI | 1 |
| Gershon, ES | 1 |
| Simmons, S | 1 |
| Ebert, M | 1 |
| Kessler, LR | 1 |
| Dibble, ED | 1 |
| Jimerson, SS | 1 |
| Brown, GM | 1 |
| Gold, P | 1 |
| Jimerson, DC | 1 |
| Guroff, JJ | 1 |
| Storch, FI | 1 |
| Stern, SL | 1 |
| Rush, AJ | 1 |
| Mendels, J | 1 |
| Max, JE | 1 |
| Richards, L | 1 |
| Hamdan-Allen, G | 1 |
| Fabian, JE | 1 |
| Strakowski, SM | 1 |
| Sax, KW | 1 |
| Setters, MJ | 1 |
| Stanton, SP | 1 |
| Schaller, JL | 1 |
| Behar, D | 1 |
| Pukhovsky, A | 1 |
| Rotzinger, S | 1 |
| Van Kammen, DP | 3 |
| Murphy, DL | 3 |
| Goode, DJ | 1 |
| Meltzer, HY | 1 |
| Mazura, TA | 1 |
| Gillin, JC | 1 |
| Graves, J | 1 |
| Murphy, D | 1 |
| Brown, WA | 1 |
| Mueller, B | 1 |
| Reus, VI | 1 |
| Silberman, E | 1 |
| Post, RM | 1 |
| Weingartner, H | 1 |
| Beckmann, H | 1 |
| Heinemann, H | 1 |
| Brumback, RA | 1 |
| Weinberg, WA | 1 |
| Fawcett, J | 1 |
| Kravitz, HM | 1 |
| Zajecka, JM | 1 |
| Schaff, MR | 1 |
| Cappeliez, P | 1 |
| Moore, E | 1 |
| Siever, LJ | 1 |
| Insel, TR | 1 |
| Hamilton, J | 1 |
| Nurnberger, J | 1 |
| Alterman, I | 1 |
| Garvey, MJ | 1 |
| Hwang, S | 1 |
| Teubner-Rhodes, D | 1 |
| Zander, J | 1 |
| Rhem, C | 1 |
| Clower, CG | 1 |
| Jacobs, D | 1 |
| Silverstone, T | 1 |
| Davies, C | 1 |
| Sanger, DJ | 1 |
| Steinberg, H | 1 |
| Tomkiewicz, M | 1 |
| U'Prichard, DC | 1 |
| Maas, JW | 1 |
| Dekirmenjian, H | 1 |
| Fawcett, JA | 1 |
| Dyson, WL | 1 |
| Barcai, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjunctive Lisdexamfetamine in Bipolar Depression[NCT01093963] | Phase 3 | 25 participants (Actual) | Interventional | 2010-01-31 | Terminated (stopped due to Enrollment goals not met) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for dextroamphetamine and Bipolar Disorder
| Article | Year |
|---|---|
Stimulants for depression: On the up and up?
Topics: Amphetamine; Antidepressive Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System S | 2016 |
Optimizing outcomes in ADHD treatment: from clinical targets to novel delivery systems.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Anxiety Disorders; Atomoxetine H | 2016 |
Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients.
Topics: Antipsychotic Agents; Bipolar Disorder; Brain; Choline; Creatine; Dextroamphetamine; Female; Humans; | 2004 |
MHPG excretion by patients with affective disorders.
Topics: Affective Symptoms; Bipolar Disorder; Brain; Catecholamines; Creatinine; Depression; Desipramine; De | 1974 |
17 trials available for dextroamphetamine and Bipolar Disorder
| Article | Year |
|---|---|
The effect of lisdexamfetamine dimesylate on body weight, metabolic parameters, and attention deficit hyperactivity disorder symptomatology in adults with bipolar I/II disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Body Weight; Dextroamphetami | 2013 |
Adjunctive lisdexamfetamine in bipolar depression: a preliminary randomized, placebo-controlled trial.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Central Nervous System Stimulants; | 2015 |
Amphetamine increases activity but not exploration in humans and mice.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Animals; Bipolar Disorder; Catecholamines; Central | 2016 |
Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers.
Topics: Adolescent; Adult; Anxiety; Bipolar Disorder; Blood Pressure; Central Nervous System Stimulants; Cog | 2003 |
Valproate attenuates dextroamphetamine-induced subjective changes more than lithium.
Topics: Adolescent; Adult; Affect; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Central Nervous Syst | 2005 |
Diltiazem, a calcium antagonist, partly attenuates the effects of dextroamphetamine in healthy volunteers.
Topics: Adult; Arousal; Attention; Bipolar Disorder; Calcium Channel Blockers; Central Nervous System Stimul | 1997 |
Lack of enhanced response to repeated d-amphetamine challenge in first-episode psychosis: implications for a sensitization model of psychosis in humans.
Topics: Adult; Arousal; Bipolar Disorder; Blinking; Central Nervous System Stimulants; Dextroamphetamine; Do | 1997 |
Lithium does not attenuate the effects of D-amphetamine in healthy volunteers.
Topics: Adult; Affect; Akathisia, Drug-Induced; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Ca | 1998 |
Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment.
Topics: Adult; Amphetamine; Bipolar Disorder; Depression; Dextroamphetamine; Euphoria; Female; Humans; Hydro | 1975 |
Differential effects of D- and L-amphetamine on the sleep of depressed patients.
Topics: Adult; Amphetamines; Bipolar Disorder; Depression; Dextroamphetamine; Female; Humans; Lithium; Male; | 1975 |
Alleviation of manic symptoms with catecholamine agonists.
Topics: Apomorphine; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Double-Blind Method; Hum | 1979 |
Prediction of antidepressant response to lithium carbonate by a 1-day administration of d-amphetamine in unipolar depressed women.
Topics: Adolescent; Adult; Age Factors; Bipolar Disorder; Blood Platelets; Clinical Trials as Topic; Dextroa | 1979 |
d-Amphetamine: effects on memory in a depressed population.
Topics: Bipolar Disorder; Depression; Dextroamphetamine; Double-Blind Method; Humans; Memory; Mental Recall; | 1979 |
[Proceedings: D-Amphetamine in manic syndrome (author's transl)].
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Female; Humans; Male; Middle A | 1976 |
Eye-tracking, attention and amphetamine challenge.
Topics: Attention; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Double-Blind Method; Eye M | 1987 |
Dextroamphetamine treatment of mania.
Topics: Acute Disease; Adult; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Female; Humans; | 1987 |
Treatment of children of lithium-responding parents.
Topics: Adolescent; Behavior; Bipolar Disorder; Child; Clinical Trials as Topic; Dextroamphetamine; Humans; | 1970 |
52 other studies available for dextroamphetamine and Bipolar Disorder
| Article | Year |
|---|---|
Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Behavior, Animal; Bipolar Disord | 2019 |
Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Calcium; Dextroamphetamine; Glutathione Peroxidase; Ind | 2020 |
The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder.
Topics: Animals; Bipolar Disorder; Dextroamphetamine; Drug Synergism; Glucagon-Like Peptide-1 Receptor; Lipi | 2020 |
Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?
Topics: Animals; Antimanic Agents; Bipolar Disorder; Cognitive Dysfunction; Dextroamphetamine; Disease Model | 2021 |
The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: Implications to the animal model of bipolar disorder.
Topics: Animals; Anxiety; Behavior, Animal; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Corp | 2019 |
Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Behavior, | 2019 |
Psychostimulants for managing unipolar and bipolar treatment-resistant melancholic depression: a medium-term evaluation of cost benefits.
Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Central Nervous System Stimulants; Cost-Benefit An | 2013 |
Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania?
Topics: Animals; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Dextroamphetamine; D | 2014 |
Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Dextroamphetamine; Euphoria; Geneti | 2014 |
Cognitive judgment bias in the psychostimulant-induced model of mania in rats.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Cocaine; Dextroamphetamine; Disease Models, Animal; Dop | 2015 |
Role of P2X7 Receptor in an Animal Model of Mania Induced by D-Amphetamine.
Topics: Animals; Bipolar Disorder; Brain; Dextroamphetamine; Disease Models, Animal; Inflammation Mediators; | 2016 |
Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Central Nervous System Stimula | 2015 |
Amphetamine sensitization in mice is sufficient to produce both manic- and depressive-related behaviors as well as changes in the functional connectivity of corticolimbic structures.
Topics: Anhedonia; Animals; Bipolar Disorder; Cerebral Cortex; Dextroamphetamine; Disease Models, Animal; Li | 2015 |
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; D | 2015 |
The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Cytokines; Dextroamphetamine; Disease Models, An | 2018 |
Do the old psychostimulant drugs have a role in managing treatment-resistant depression?
Topics: Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Central Nervous System Stimulants; Depres | 2010 |
GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Dextroamphetamine; Disease Models, Animal; Dopamine Pla | 2010 |
Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Central Nervous System Stimulants; De | 2010 |
Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Corpus Striatum; Dextroamphetamine; Disease Mode | 2010 |
Tamoxifen effects on respiratory chain complexes and creatine kinase activities in an animal model of mania.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Creatine Kinase; Dextroamphetamine; Disease Mode | 2011 |
N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder.
Topics: Acetylcysteine; Animals; Bipolar Disorder; Brain; Corpus Striatum; Cyclohexanones; Dextroamphetamine | 2011 |
Behavioral and neurochemical effects of sodium butyrate in an animal model of mania.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Butyric Acid; Central Nervous | 2011 |
Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Body Weight; Central Nervous System S | 2012 |
Protein kinase C and oxidative stress in an animal model of mania.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Dextroamphetamine; Disease Mod | 2012 |
K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β.
Topics: Animals; Antimanic Agents; Autoradiography; Benzamides; Bipolar Disorder; Carbamates; Central Nervou | 2012 |
Effects of alpha-lipoic acid in an animal model of mania induced by D-amphetamine.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Central Nervo | 2012 |
Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania.
Topics: Animals; Antimanic Agents; Apoptosis; Behavior, Animal; Bipolar Disorder; Blotting, Western; Dextroa | 2012 |
Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats.
Topics: Affect; Animals; Antimetabolites; Anxiety; Behavior, Animal; Bipolar Disorder; Bromodeoxyuridine; Ce | 2013 |
Evaluation of acetylcholinesterase in an animal model of mania induced by D-amphetamine.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Cent | 2013 |
Effects of lithium on oxidative stress and behavioral alterations induced by lisdexamfetamine dimesylate: relevance as an animal model of mania.
Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain Chemistry; Central Nervous Syst | 2013 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
Stimulant-atypical antipsychotic interaction and acute dystonia.
Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar | 2005 |
Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania.
Topics: Animals; Bipolar Disorder; Central Nervous System Stimulants; Corpus Striatum; Dextroamphetamine; Hi | 2006 |
Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.
Topics: Animals; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Catalase; Dextroamphetamine; Disease M | 2006 |
A gastrin-releasing peptide receptor antagonist blocks D-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in rats.
Topics: Animals; Bipolar Disorder; Bombesin; Brain-Derived Neurotrophic Factor; Dextroamphetamine; Hippocamp | 2007 |
Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania.
Topics: Acetylcysteine; Animals; Bipolar Disorder; Central Nervous System Stimulants; Deferoxamine; Dextroam | 2008 |
Changes in locomotor response to beta-endorphin microinfusion during and after opiate abstinence syndrome--a proposal for a model of the onset of mania.
Topics: Affective Disorders, Psychotic; Animals; beta-Endorphin; Bipolar Disorder; Dextroamphetamine; Diseas | 1982 |
Clinical implications of research on the mechanism of action of lithium.
Topics: Adenylyl Cyclase Inhibitors; Animals; Bipolar Disorder; Brain; Cyclic AMP; Demeclocycline; Dextroamp | 1983 |
Biologic markers and antidepressant response.
Topics: Antidepressive Agents; Biological Transport; Bipolar Disorder; Depressive Disorder; Dexamethasone; D | 1983 |
Carbamazepine-induced mania in two children: case report.
Topics: Age Factors; Bipolar Disorder; Carbamazepine; Chemical Phenomena; Chemistry; Child; Depressive Disor | 1984 |
Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and 'well-state' bipolar patients.
Topics: Adolescent; Adult; Bipolar Disorder; Blood Pressure; Dextroamphetamine; Emotions; Female; Growth Hor | 1982 |
Toward a rational pharmacotherapy of depression.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Depression; Dextroamphetamine; Dose-Response Rel | 1980 |
Case study: antimanic effectiveness of dextroamphetamine in a brain-injured adolescent.
Topics: Adolescent; Bipolar Disorder; Brain Damage, Chronic; Cerebral Ventricles; Dextroamphetamine; Humans; | 1995 |
Treatment of a case of comorbid bipolar disorder and attention-deficit/hyperactivity disorder.
Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Attention Deficit Disorder with H | 1998 |
Hoffmann reflex abnormalities in psychotic patients.
Topics: Acute Disease; Adult; Antipsychotic Agents; Bipolar Disorder; Chlorpromazine; Chronic Disease; Dextr | 1979 |
Childhood depression: an explanation of a behavior disorder of children.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Child; Child Behavior Disorders; Depression; Dex | 1977 |
CNS stimulant potentiation of monoamine oxidase inhibitors in treatment-refractory depression.
Topics: Bipolar Disorder; Depressive Disorder; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Syn | 1991 |
Effects of lithium on an amphetamine animal model of bipolar disorder.
Topics: Animals; Bipolar Disorder; Chlorides; Dextroamphetamine; Disease Models, Animal; Lithium; Lithium Ch | 1990 |
Treatment of mania with dextroamphetamine.
Topics: Bipolar Disorder; Dextroamphetamine; Humans | 1988 |
Dextroamphetamine-induced arousal in human subjects as a model for mania.
Topics: Administration, Oral; Adult; Affect; Arousal; Bipolar Disorder; Blood Pressure; Dextroamphetamine; D | 1986 |
Lithium and alpha-methyl-p-tyrosine prevent "manic" activity in rodents.
Topics: Animals; Bipolar Disorder; Chlordiazepoxide; Dextroamphetamine; Disease Models, Animal; Drug Combina | 1974 |
A two factor theory of schizophrenia.
Topics: Acetylcholine; Amphetamine; Animals; Bipolar Disorder; Brain; Dextroamphetamine; Dopamine; Dose-Resp | 1974 |