dextroamphetamine has been researched along with Attention Deficit and Disruptive Behavior Disorders in 5 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
Attention Deficit and Disruptive Behavior Disorders: Includes two similar disorders: oppositional defiant disorder and CONDUCT DISORDERS. Symptoms occurring in children with these disorders include: defiance of authority figures, angry outbursts, and other antisocial behaviors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Children whose aggressive behavior persisted at the conclusion of the lead-in phase were randomly assigned to receive double-blind, flexibly dosed divalproex or a placebo adjunctive to stimulant for 8 weeks." | 2.74 | Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. ( Blader, JC; Jensen, PS; Kafantaris, V; Pliszka, SR; Schooler, NR, 2009) |
| "Risperidone-treated patients had clinically and statistically significant reductions in both disruptive behavior and hyperactivity subscale scores, compared to placebo, regardless of concomitant stimulant use." | 2.71 | Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ. ( Aman, MG; Binder, C; Turgay, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keen, D | 1 |
| Hadijikoumi, I | 1 |
| Blader, JC | 1 |
| Schooler, NR | 1 |
| Jensen, PS | 1 |
| Pliszka, SR | 1 |
| Kafantaris, V | 1 |
| Aman, MG | 1 |
| Binder, C | 1 |
| Turgay, A | 1 |
| Chabot, RJ | 1 |
| Orgill, AA | 1 |
| Crawford, G | 1 |
| Harris, MJ | 1 |
| Serfontein, G | 1 |
| Kariyawasam, SH | 1 |
| Zaw, F | 1 |
| Handley, SL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind, Placebo-Controlled Trial of Flexible Dose Divalproex Sodium Adjunctive to Stimulant Treatment for Aggressive Children With Attention-Deficit Hyperactivity Disorder[NCT00228046] | Phase 4 | 40 participants (Anticipated) | Interventional | 2004-01-31 | Completed | ||
| The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)[NCT04964427] | 26 participants (Actual) | Interventional | 2021-02-08 | Completed | |||
| Pediatric Attention Deficit Hyperactivity Disorder: Predicting Clinical Response to Stimulant Medication From Single-dose Changes in Event Related Potentials[NCT02695355] | Phase 2 | 87 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for dextroamphetamine and Attention Deficit and Disruptive Behavior Disorders
| Article | Year |
|---|---|
ADHD in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit and Disruptive Behavior Disorders; Attentio | 2008 |
3 trials available for dextroamphetamine and Attention Deficit and Disruptive Behavior Disorders
| Article | Year |
|---|---|
Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy.
Topics: Adolescent; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Atten | 2009 |
Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ.
Topics: Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorde | 2004 |
Behavioral and electrophysiologic predictors of treatment response to stimulants in children with attention disorders.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants; | 1999 |
Behavioral and electrophysiologic predictors of treatment response to stimulants in children with attention disorders.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants; | 1999 |
Behavioral and electrophysiologic predictors of treatment response to stimulants in children with attention disorders.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants; | 1999 |
Behavioral and electrophysiologic predictors of treatment response to stimulants in children with attention disorders.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants; | 1999 |
1 other study available for dextroamphetamine and Attention Deficit and Disruptive Behavior Disorders
| Article | Year |
|---|---|
Reduced salivary cortisol in children with comorbid Attention deficit hyperactivity disorder and oppositional defiant disorder.
Topics: Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; | 2002 |