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dextroamphetamine and Anorexia

dextroamphetamine has been researched along with Anorexia in 31 studies

Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.

Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.

Research Excerpts

ExcerptRelevanceReference
"Although amphetamine anorexia has been linked to activation of dopaminergic receptors within the lateral aspects of the hypothalamus, the receptor type by which phenylpropanolamine (PPA: the racemic mixture of d- and l-norephedrine) induces anorexia has not been identified."7.68Effects of haloperidol on anorexia induced by l-norephedrine and d-amphetamine in adult rats. ( Wellman, PJ, 1990)
"The concept of dopamine receptor subtypes and the recent development of selective dopamine receptor agonists and antagonists raises the possibility of specific subtype involvement in amphetamine-induced anorexia, and, furthermore, provides the means to evaluate the possibility."7.67Analysis of dopamine D1 and D2 receptor involvement in d- and l-amphetamine-induced anorexia in rats. ( Cooper, SJ; Gilbert, DB, 1985)
"Amantadine hydrochloride (Symmetrel), an antiviral, antiparkinson agent that is most frequently used clinically at oral doses of 2 to 3 mg/kg, significantly decreased d-amphetamine-induced CNS stimulation (motor activity) and simultaneously increased d-amphetamine-induced anorexia (milk intake) in mice."7.65Amantadine decreases d-amphetamine stimulation and increases d-amphetamine anorexia in mice. ( Clark, R; Rubin, AA; Smith, DH; Vernier, VG, 1976)
"Although amphetamine anorexia has been linked to activation of dopaminergic receptors within the lateral aspects of the hypothalamus, the receptor type by which phenylpropanolamine (PPA: the racemic mixture of d- and l-norephedrine) induces anorexia has not been identified."3.68Effects of haloperidol on anorexia induced by l-norephedrine and d-amphetamine in adult rats. ( Wellman, PJ, 1990)
"Amphetamine-induced anorexia and stereotyped behaviour were studied in rats, following pretreatment with the antidepressants DMI, inprindole and mianserin."3.67Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs. ( Montgomery, T; Towell, A; Willner, P, 1984)
"The concept of dopamine receptor subtypes and the recent development of selective dopamine receptor agonists and antagonists raises the possibility of specific subtype involvement in amphetamine-induced anorexia, and, furthermore, provides the means to evaluate the possibility."3.67Analysis of dopamine D1 and D2 receptor involvement in d- and l-amphetamine-induced anorexia in rats. ( Cooper, SJ; Gilbert, DB, 1985)
" Therefore, we tested the effect of intrahypothalamic injections of sulpiride, a specific D2 receptor blocker, on amphetamine anorexia in food-deprived rats, and on spontaneous feeding and drinking in satiated rats."3.67Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats. ( Hernandez, L; Hoebel, BG; Parada, MA, 1988)
"Development of a contingent tolerance to amphetamine (AMPH) anorexia has been reported with chronic s."3.67Dissociation of receptor sensitivity changes in rat perifornical hypothalamus: a role for dopaminergic receptors in amphetamine anorexic tolerance. ( Bhakthavatsalam, P; Ghosh, MN; Kamatchi, GL, 1987)
" Among the hallucinogens decreasing food intake, both LSD and atropine produced substantial anorexia, but the slopes of their dose-response curves were clearly different from d-amphetamine."3.66Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens. ( Morton, EC; Vaupel, DB, 1982)
"Amantadine hydrochloride (Symmetrel), an antiviral, antiparkinson agent that is most frequently used clinically at oral doses of 2 to 3 mg/kg, significantly decreased d-amphetamine-induced CNS stimulation (motor activity) and simultaneously increased d-amphetamine-induced anorexia (milk intake) in mice."3.65Amantadine decreases d-amphetamine stimulation and increases d-amphetamine anorexia in mice. ( Clark, R; Rubin, AA; Smith, DH; Vernier, VG, 1976)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199028 (90.32)18.7374
1990's1 (3.23)18.2507
2000's1 (3.23)29.6817
2010's1 (3.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
White, W1
Hundley, MB1
White, IM1
HARRIS, SC1
IVY, AC1
Vaupel, DB1
Morton, EC1
Golinko, BE2
Willner, P3
Towell, A2
Montgomery, T2
McCabe, JT1
Leibowitz, SF1
Leshem, M1
Arnerić, SP1
Roetker, A1
Long, JP1
Hoebel, BG2
Hernandez, L2
Monaco, AP1
Miller, WC1
Tordoff, MG1
Hopfenbeck, J1
Butcher, LL1
Novin, D1
Bendotti, C1
Borsini, F1
Cotecchia, S1
De Blasi, A1
Mennini, T1
Samanin, R1
Paul, SM1
Hulihan-Giblin, B1
Skolnick, P1
Lutz, TA1
Tschudy, S1
Mollet, A1
Geary, N1
Scharrer, E1
Dobrzanski, S3
Doggett, NS3
Burridge, SL1
Blundell, JE1
Lazareno, S1
Antelman, SM1
Caggiula, AR1
Black, CA1
Edwards, DJ1
Koob, GF1
Riley, SJ1
Smith, SC1
Robbins, TW1
Clark, R1
Smith, DH1
Vernier, VG1
Rubin, AA1
Livingston, S1
Pauli, LL1
Wellman, PJ1
Dulcan, MK1
Gilbert, DB1
Cooper, SJ1
Muscat, R1
Parada, MA1
Bhakthavatsalam, P2
Kamatchi, GL2
Ghosh, MN2

Trials

1 trial available for dextroamphetamine and Anorexia

ArticleYear
Side effects of dexedrine in hyperactive children: operationalization and quantification in a short-term trial.
    Progress in neuro-psychopharmacology & biological psychiatry, 1982, Volume: 6, Issue:2

    Topics: Anorexia; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Dextroamphetamine; Dose

1982

Other Studies

30 other studies available for dextroamphetamine and Anorexia

ArticleYear
The effects of dose and repeated administration on the longer-term hypophagia produced by amphetamine in rats.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 97, Issue:2

    Topics: Animals; Anorexia; Appetite Depressants; Conditioning, Operant; Dextroamphetamine; Dose-Response Rel

2010
The influence of extrinsic gastro-intestinal innervation on dexedrine induced anorexia.
    Federation proceedings, 1946, Volume: 5, Issue:1 Pt 2

    Topics: Anorexia; Appetite; Dextroamphetamine; Feeding and Eating Disorders; Gastrointestinal Tract; Humans

1946
Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Amphetamine; Animals; Anorexia; Atropine; Dextroamphetamine; Dogs; Dronabinol; Feeding and Eating Di

1982
Side effects of dextroamphetamine and methylphenidate in hyperactive children--a brief review.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:1

    Topics: Anorexia; Attention Deficit Disorder with Hyperactivity; Body Weight; Child; Dextroamphetamine; Grow

1984
Changes in amphetamine-induced anorexia and stereotypy during chronic treatment with antidepressant drugs.
    European journal of pharmacology, 1984, Mar-02, Volume: 98, Issue:3-4

    Topics: Animals; Anorexia; Antidepressive Agents, Tricyclic; Desipramine; Dextroamphetamine; Dose-Response R

1984
Determination of the course of brainstem catecholamine fibers mediating amphetamine anorexia.
    Brain research, 1984, Oct-08, Volume: 311, Issue:2

    Topics: Afferent Pathways; Animals; Anorexia; Brain; Brain Stem; Catecholamines; Dextroamphetamine; Feeding

1984
Morphine-induced anorexia in lateral hypothalamic rats.
    Psychopharmacology, 1981, Volume: 75, Issue:1

    Topics: Amphetamine; Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Fenfluramine; Human

1981
Behavioural changes during withdrawal from desmethylimipramine (DMI). I. Interactions with amphetamine.
    Psychopharmacology, 1981, Volume: 75, Issue:1

    Topics: Animals; Anorexia; Desipramine; Dextroamphetamine; Drug Interactions; Eating; Feeding and Eating Dis

1981
Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists.
    Neuropharmacology, 1982, Volume: 21, Issue:9

    Topics: Animals; Anorexia; Apomorphine; Dextroamphetamine; Energy Intake; Feeding Behavior; Indans; Indenes;

1982
Amphetamine-induced overeating and overweight in rats.
    Life sciences, 1981, Jan-05, Volume: 28, Issue:1

    Topics: Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Feeding Behavior; Female; Humans

1981
A peripheral locus for amphetamine anorexia.
    Nature, 1982, May-13, Volume: 297, Issue:5862

    Topics: Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Feeding Behavior; Humans; Liver;

1982
d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 260, Issue:1

    Topics: Animals; Anorexia; Brain; Dextroamphetamine; Drug Tolerance; Feeding and Eating Disorders; Humans; M

1982
(+)-Amphetamine binding to rat hypothalamus: relation to anorexic potency for phenylethylamines.
    Science (New York, N.Y.), 1982, Oct-29, Volume: 218, Issue:4571

    Topics: Animals; Anorexia; Appetite Depressants; Cell Membrane; Dextroamphetamine; Hypothalamus; Male; Phene

1982
Dopamine D(2) receptors mediate amylin's acute satiety effect.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:6

    Topics: Amyloid; Animals; Anorexia; Benzazepines; Circadian Rhythm; Dextroamphetamine; Dopamine Agents; Dopa

2001
On the relation between hypodipsia and anorexia induced by (+)-amphetamine in the mouse.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:12

    Topics: Animals; Anorexia; Depression, Chemical; Dextroamphetamine; Dose-Response Relationship, Drug; Drinki

1976
Amphetamine anorexia: antagonism by typical but not atypical neuroleptics.
    Neuropharmacology, 1979, Volume: 18, Issue:5

    Topics: Animals; Anorexia; Antipsychotic Agents; Dextroamphetamine; Feeding and Eating Disorders; Feeding Be

1979
d-Amphetamine and punished responding: the role of catecholamines and anorexia.
    Psychopharmacology, 1979, Volume: 66, Issue:2

    Topics: Animals; Anorexia; Antipsychotic Agents; Catecholamines; Clozapine; Conditioning, Operant; Dextroamp

1979
Stress reverse the anorexia induced by amphetamine and methylphenidate but not fenfluramine.
    Brain research, 1978, Mar-31, Volume: 143, Issue:3

    Topics: Animals; Anorexia; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eating Disorders

1978
Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.
    Journal of comparative and physiological psychology, 1978, Volume: 92, Issue:5

    Topics: Anorexia; Attention; Central Nervous System; Dextroamphetamine; Dopamine; Drinking Behavior; Feeding

1978
Proceedings: Effect of dopamine-beta-hydroxylase inhibitors and centrally administered noradrenaline on (+)-amphetamine anorexia in mice.
    British journal of pharmacology, 1975, Volume: 54, Issue:2

    Topics: Animals; Anorexia; Cerebral Ventricles; Dextroamphetamine; Dopamine beta-Hydroxylase; Drug Synergism

1975
Amantadine decreases d-amphetamine stimulation and increases d-amphetamine anorexia in mice.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1976, Volume: 151, Issue:2

    Topics: Amantadine; Animals; Anorexia; Dextroamphetamine; Drug Interactions; Feeding and Eating Disorders; F

1976
Studies in mice on the antagonism of (+)-amphetamine anorexia by alpha-methyl-p-tyrosine methyl ester HCl.
    Neuropharmacology, 1976, Volume: 15, Issue:10

    Topics: Animals; Anorexia; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Fe

1976
Dextroamphetamine for epilepsy.
    JAMA, 1975, Jul-21, Volume: 233, Issue:3

    Topics: Adolescent; Adult; Anorexia; Capsules; Child; Child, Preschool; Dextroamphetamine; Drug Evaluation;

1975
Effects of haloperidol on anorexia induced by l-norephedrine and d-amphetamine in adult rats.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:2

    Topics: Animals; Anorexia; Dextroamphetamine; Drug Interactions; Eating; Feeding and Eating Disorders; Halop

1990
Attention deficit disorder: evaluation and treatment.
    Pediatric annals, 1985, Volume: 14, Issue:5

    Topics: Age Factors; Anorexia; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Body Height;

1985
Analysis of dopamine D1 and D2 receptor involvement in d- and l-amphetamine-induced anorexia in rats.
    Brain research bulletin, 1985, Volume: 15, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Anorexia; Appetite

1985
Behavioural microanalysis of the role of dopamine in amphetamine anorexia.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:3

    Topics: Animals; Anorexia; Apomorphine; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eat

1988
Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Anorexia; Dextroamphetamine; Dose-Response Relationship, Drug; Drinking Behavior; Feeding B

1988
Dissociation of receptor sensitivity changes in rat perifornical hypothalamus: a role for dopaminergic receptors in amphetamine anorexic tolerance.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Amphetamine; Animals; Anorexia; Benserazide; Dextroamphetamine; Drug Tolerance; Eating; Feeding and

1987
Tolerance pattern to amphetamine anorexia after selective lesions in the hypothalamic dopaminergic projection.
    Life sciences, 1985, Aug-19, Volume: 37, Issue:7

    Topics: Animals; Anorexia; Body Weight; Dextroamphetamine; Dopamine; Drug Tolerance; Energy Intake; Feeding

1985