dextroamphetamine has been researched along with Anankastic Personality in 11 studies
Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
(S)-amphetamine : A 1-phenylpropan-2-amine that has S configuration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two small, double-blind, placebo-controlled, single-dose, crossover studies found dextroamphetamine (d-amphetamine) 30 mg clearly superior to placebo in relieving symptoms of obsessive-compulsive disorder (OCD)." | 9.14 | Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. ( Aboujaoude, E; Gamel, NN; Koran, LM, 2009) |
| "Two small, double-blind, placebo-controlled, single-dose, crossover studies found dextroamphetamine (d-amphetamine) 30 mg clearly superior to placebo in relieving symptoms of obsessive-compulsive disorder (OCD)." | 5.14 | Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder. ( Aboujaoude, E; Gamel, NN; Koran, LM, 2009) |
| "The effects of acute oral administration of methylphenidate 40 mg versus dextroamphetamine 30 mg versus matched placebo were compared in 11 patients with primary obsessive-compulsive disorder." | 5.07 | Acute psychostimulant challenge in primary obsessive-compulsive disorder. ( Joffe, RT; Levitt, AJ; Swinson, RP, 1991) |
| "Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate." | 2.67 | Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability? ( Amass, J; Borcherding, BG; Elia, J; Keysor, CS; Rapoport, JL, 1990) |
| "pramipexole) known to produce compulsive behaviors in humans would increase marble burying." | 1.37 | Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety. ( Jimenez-Gomez, C; Osentoski, A; Woods, JH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denys, D | 1 |
| de Vries, F | 1 |
| Cath, D | 1 |
| Figee, M | 1 |
| Vulink, N | 1 |
| Veltman, DJ | 1 |
| van der Doef, TF | 1 |
| Boellaard, R | 1 |
| Westenberg, H | 1 |
| van Balkom, A | 1 |
| Lammertsma, AA | 1 |
| van Berckel, BN | 1 |
| Koran, LM | 1 |
| Aboujaoude, E | 1 |
| Gamel, NN | 1 |
| Jimenez-Gomez, C | 1 |
| Osentoski, A | 1 |
| Woods, JH | 1 |
| Schmidt, TT | 1 |
| Rea, E | 1 |
| Shababi-Klein, J | 1 |
| Panagis, G | 1 |
| Winter, C | 1 |
| Woolley, JB | 1 |
| Heyman, I | 1 |
| Insel, TR | 2 |
| Hamilton, JA | 1 |
| Guttmacher, LB | 1 |
| Murphy, DL | 2 |
| Harvey, BH | 1 |
| Scheepers, A | 1 |
| Brand, L | 1 |
| Stein, DJ | 1 |
| Joffe, RT | 1 |
| Swinson, RP | 1 |
| Levitt, AJ | 1 |
| Borcherding, BG | 1 |
| Keysor, CS | 1 |
| Rapoport, JL | 1 |
| Elia, J | 1 |
| Amass, J | 1 |
| Siever, LJ | 1 |
| Hamilton, J | 1 |
| Nurnberger, J | 1 |
| Alterman, I | 1 |
| Ideström, CM | 1 |
| Schalling, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Trial of Acute and Intermediate-term Dextro-amphetamine Versus Caffeine Augmentation in Treatment Resistant Obsessive Compulsive Disorder (OCD)[NCT00363298] | 24 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Global Impressions Scale Improvement Score = 1 (very much improved), or 2 (much improved). Additional possible scale scores are 3 (minimally improved), 4 (no change), 5 (minimally worse), 6 (much worse) and 7 (very much worse). (NCT00363298)
Timeframe: At end of week 5, except 1 d-amphetamine subject rated at end of week 2
| Intervention | participants (Number) |
|---|---|
| D-amphetamine | 6 |
| Caffeine Pills | 7 |
"Yale-Brown Obsessive-Compulsive Scale score by blinded investigator in direct interview. The scale score is the sum of ten items (5 for obsessions and 5 for compulsions: time occupied, degree of interference with functioning, degree of distress, effort to resist the symptom, success in resisting), each rated from 0 to 4, with higher scores indicating more severe OCD. Maximum score is 40. Scores of 14 and below are often described as subclinical, though patients with these scores may still exhibit troubling symptoms and mild to moderate distress. A total score of 8 or less is often termed remission. A decrease in total score from baseline to endpoint of either 25% or 35% is often used as a responder criterion in clinical trials." (NCT00363298)
Timeframe: At end of week 5, except 1 d-amphetamine subject rated at end of week 2
| Intervention | units on a scale (Mean) |
|---|---|
| D-amphetamine | 13.3 |
| Caffeine Pills | 13.0 |
6 trials available for dextroamphetamine and Anankastic Personality
| Article | Year |
|---|---|
Double-blind study of dextroamphetamine versus caffeine augmentation for treatment-resistant obsessive-compulsive disorder.
Topics: Adult; Caffeine; Dextroamphetamine; Diagnostic and Statistical Manual of Mental Disorders; Double-Bl | 2009 |
D-amphetamine in obsessive-compulsive disorder.
Topics: Adolescent; Adult; Dextroamphetamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Obsess | 1983 |
Acute psychostimulant challenge in primary obsessive-compulsive disorder.
Topics: Adult; Behavior; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Methylp | 1991 |
Motor/vocal tics and compulsive behaviors on stimulant drugs: is there a common vulnerability?
Topics: Attention Deficit Disorder with Hyperactivity; Child; Compulsive Behavior; Dextroamphetamine; Double | 1990 |
Eye-tracking, attention and amphetamine challenge.
Topics: Attention; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Double-Blind Method; Eye M | 1987 |
Objective effects of dexamphetamine and amobarbital and their relations to psychasthenic personality traits.
Topics: Adult; Amobarbital; Analysis of Variance; Blood Pressure; Clinical Trials as Topic; Cognition; Dextr | 1970 |
5 other studies available for dextroamphetamine and Anankastic Personality
| Article | Year |
|---|---|
Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Corpus Striatum; Dextroamphetamine; Dopamine; Dop | 2013 |
Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Benzothiazoles; Carbolin | 2011 |
Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive-compulsive disorder.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphe | 2013 |
Dexamphetamine for obsessive-compulsive disorder.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2003 |
Chronic inositol increases striatal D(2) receptors but does not modify dexamphetamine-induced motor behavior. Relevance to obsessive-compulsive disorder.
Topics: Animals; Corpus Striatum; Dextroamphetamine; Dopamine Agents; Female; Guinea Pigs; Inositol; Male; M | 2001 |