Page last updated: 2024-08-24

dexmedetomidine and Pain

dexmedetomidine has been researched along with Pain in 141 studies

Research

Studies (141)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's26 (18.44)29.6817
2010's63 (44.68)24.3611
2020's52 (36.88)2.80

Authors

AuthorsStudies
Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H1
Ding, X; Guo, J; Ren, X; Su, C; Wang, H1
Bharati, SJ; Bhatnagar, S; Garg, R; Gupta, N; Hadda, V; Kumar, V; Madan, K; Mishra, S; Mittal, S; Mohan, A; Sagiraju, HKR; Sirohiya, P1
Campher, MJJ; Eley, VA; Laupland, KB; Sin, JCK; Tabah, A1
Moshari, A; Moshari, M; Vahedi, Z1
Feng, YJ; Han, J; Pu, CX; Tang, LJ; Zhang, Y1
Hui, D; Jianwei, G; Jing, Z; Lijuan, Z; Ronglin, L; Yanan, J1
Chen, XL; Huang, WH; Zhang, GC; Zheng, YH1
Cao, R; Fan, M; Hu, L; Li, J; Lu, S1
Cren, R; De Kock, M; Grégoire, C; Henrie, J; Lavand'homme, P; Penaloza, A; Verschuren, F1
He, Y; Hu, R; Ning, R; Niu, J; Sun, H; Yang, N; Yu, J1
Huang, Z; Lai, L; Shan, R; Sun, C; Xiao, C; Zhan, L; Zhang, X; Zhao, W1
Chai, X; Chu, L; Liao, B; Wang, XF; Wei, JM; Yang, JS; Zhang, R; Zhang, X; Zhao, YT; Zou, P1
Al Assadi, S; Kanazi, G; Karam, C; Zeeni, C1
Lu, YJ; Shao, JL; Shen, R; Wang, L; Yang, ZH; Zhan, FF1
Jiang, L; Lu, B; Pang, G; Rao, C; Tong, S; Zhu, Y1
Azemati, S; Jouybar, R; Naderi-Boldaji, V; Zarghami, A1
Anghelescu, DL; Baker, JN; Bhatia, S; Cuviello, A; Johnson, LM; Pasli, M1
Hao, D; Zhang, Z1
Abramson, J; Dorling, J; Ojha, S1
Avet, C; Basbaum, AI; Bouvier, M; Braz, JM; Chen, G; Craik, V; Du, Y; Fink, EA; Gahbauer, S; Gmeiner, P; Huang, XP; Hübner, H; Irwin, JJ; Jacobson, MP; Kalyanaraman, C; Liu, Z; Moroz, YS; Schmidt, MF; Seemann, P; Shoichet, BK; Tolmachova, NA; Webb, CM; Weikert, D; Xu, J1
Chen, Y; Cheng, O; Cui, J; Li, C; Li, Y; Zhu, D1
Bartoletta, KM; Collura, CA; Thorvilson, MJ1
Bäcke, P; Bruschettini, M; Olsson, E; Sibrecht, G; Thernström Blomqvist, Y1
Miskimins, R; Mitchell, J; Sarangarm, P; Wiemann, B1
Garip, L; Mesotten, D; Meyns, J; Stragier, H; Verbist, J; Vundelinckx, J1
Ahuja, V; Aravindan, A; Datta, PK; Ganesh, V; Iyer, KV; Khanna, P; Maitra, S; Sarkar, S; Singh, A1
Dersch-Mills, D; Howlett, A; Lind, J; Marchuk, A; Mohammad, K1
Huang, Y; Wang, C; Wang, T; Wang, X; Wu, H; Zhang, S; Zhao, G1
Al-Bermani, T; Al-Mufti, F; Ali, S; Bass, B; Bauerschmidt, A; Dorilio, J; Rosenberg, J1
Geng, D; Gu, C; Hao, Y; Li, X; Qian, X; Shi, Y; Tao, H; Yang, X; Zhang, C; Zhang, L; Zhou, J1
He, Y; Hou, YB; Ning, RD; Niu, JY; Tao, QY; Yang, N; Yu, JM1
Dieudonné Rahm, N; Elia, N; Gil Wey, B; Habre, W; Pautex, S; Zaccaria, I1
Raman, R; Raman, S; Surya, J; Viswanathan, J1
Chen, C; Chen, W; Gao, P; Li, YH; Lu, Y; Rao, J1
Li, Z; Lu, Y; Ma, X; Sun, H; Wang, S; Zhu, H1
Harada, H; Ikeda, K; Kamei, J; Kato, T; Kitajima, N; Kuriyama, A; Maeda, J; Matsuyama, A; Minami, T; Mizota, T; Ohtsuru, S; Sakai, Y; Sato, Y; Takatani, Y; Ueno, K; Watanabe, H; Yamaji, K; Yamashita, Y1
Hao, C; Li, H; Luan, H; Zhang, X; Zhao, Z; Zhu, P1
Konishi, S; Miyashima, Y; Nakamura, H; Uemura, T1
Dinges, HC; Eberhart, L; Schubert, AK; Seneviratne, V; Stolz, J; Wiesmann, T; Wulf, H1
Bromfalk, Å; Engström, Å; Hultin, M; Myrberg, T; Walldén, J1
Du, B; Guo, Q; Qi, X; Wang, B; Xiao, F; Zhang, H; Zhang, J1
Ali, KA; Deng, X; Fang, Z; Li, W; Li, Y1
Cheng, Y; Li, S; Lin, Z; Lu, X; Sun, J; Yang, B; Yu, Z; Zhou, Y1
Anderson, J; Mandell, SP; McClellan, JM; O'Neal, J; Sheckter, C; Stanton, E1
Kim, MD1
Donato, J; Lewis, T; Rao, K1
Carregaro, AB; de Carvalho, LL; Flaherty, D; Mattos-Junior, E; Nishimura, LT1
El-Dib, M; Inder, TE; Massaro, AN; McPherson, C; Miller, SP1
Ji, L; Lan, Y; Sun, W; Wu, Q; Xia, C; Xu, X; Yang, S; Yu, G1
Date, K; Iino, K; Kawata, M; Kyo, S; Mano, A; Murata, T; Saito, E; Sato, M; Yamashita, N1
Cox, CE; Gilstrap, DL; Kram, BL; Kram, SJ; Ohman, KL; Schultheis, JM; Yang, Z1
Järvisalo, MJ; Seppänen, SM; Uusalo, P1
Atyia, SA; Cape, KM; May, CC; Smetana, KS; Thompson, MJ; Tong, MC1
Leng, YF; Liu, YQ; Wan, ZH; Wang, DG; Yan, X; Zhang, H; Zhang, Y1
Davoudi, A; Movahedian Attar, B; Shadmehr, E1
Hu, B; Li, JG; Peng, ZY; Rao, X; Wang, J; Zhou, WH1
Aoun, Z; Bazarbachi, T; Dabar, G; Habr, B; Ibrahim, I; Khalil, N; Khayat, G; Riachy, M1
Amaya, F; Matsuda, M; Sawa, T; Yamaguchi, Y; Yamakita, S1
Chen, CJ; Hei, ZQ; Li, X; Pan, JR; Tan, F; Xing, JB; Zhou, SL; Zhu, QQ1
Han, LL; Li, QD; Li, SW; Li, WW; Shi, HY; Wan, XY; Zhang, YL1
Bruña, V; Devesa, C; Fernández-Avilés, F; Gonzalez-Saldivar, H; Iglesias, M; Juárez, M; Martínez-Sellés, M; Sousa-Casasnovas, I; Valero-Masa, MJ; Vicent, L1
Chlan, L; Hayes, SM; Hetland, B; Skaar, D; Tracy, MF; Weinert, CR1
Berggren, L; Blomqvist, H; Forsberg, S; Nunes, SL; Sarapohja, T; Sörberg, M; Wickerts, CJ1
Chen, WR; Ji, FH; Meng, XW; Peng, K; Zhang, J1
Hu, B; Zhou, H; Zou, X1
Hua, H; Jiang, M; Liu, Z; Xu, T1
Matsumoto, Y; Murakami, Y; Nakata, M; Torumi, T; Yoshimura, M1
Xie, M; Xie, S1
Kiski, D; Malec, E; Schmidt, C1
Yu, Y; Zhang, T; Zhang, W; Zhu, J1
Coursey, CD; Lizarraga, I; Scallan, EM; Simon, BT; Wild, JL1
Chambers, P; Karna, SR; Kongara, K; Lopez-Villalobos, N; Singh, PM1
Abrams, D; Agerstrand, C; Brodie, D; Dzierba, AL; Madahar, P; Muir, J1
Cao, J; Kong, M; Li, C; Liu, H; Ma, H; Zhang, H; Zhang, L; Zhang, P; Zhang, S; Zhou, F1
Asmussen, S; Fraser, JF; George, S; Jennings, K; Maybauer, DM; Maybauer, MO1
Bergfeld, C; Beyerbach, M; Kästner, SB; Voigt, AM1
Chang, CH; Han, DW; Kim, MD; Kim, SY; Kim, YJ; Lee, JS1
Bosmans, T; de Rooster, H; Debille, M; Duchateau, L; Polis, I; Porters, N1
Jang, Y; Kang, ES; Kang, JW; Song, HK; Yeom, MY1
Dong, C; Lu, Y; Yu, J; Zhang, Y1
Malotte, K; Rosielle, DA; Walker, K1
Chen, XD; Meng, QT; Pan, X; Xia, ZY; Yang, YC1
Bosmans, T; de Rooster, H; Duchateau, L; Goethals, K; Moons, CP; Polis, I; Porters, N1
Baek, J; Joo, J; Lee, J1
Cheung, W; Deyell, R; Görges, M; Lauder, G; West, N; Winton, P1
He, L; He, T; Liu, L; Xu, JM; Zhu, R1
Huang, F; Jin, J; Kong, J; Liu, S; Wang, J; Xu, H; Yang, X1
Afsar, N; Almeida, LE; Calhoun, G; Finkel, JC; Kenyon, N; Nouraie, M; Quezado, ZM; Wang, L1
Cheung, CW; Li, S; Qian, L; Wu, Y; Yang, Y; Yao, Y; Yu, C1
Darbari, DS; Finkel, JC; Guerrera, MF; Quezado, ZM; Sheehy, KA1
Dong, C; Feng, F; Li, J; Qi, Y; Song, R; Yang, J; Yang, Z; Zhang, H1
Dong, C; Li, J; Song, R; Yang, J1
An, Y; Feng, Y; Liu, D; Lyu, J1
Cao, WZ; Xu, SA; Xu, XQ; Yu, HJ1
Chen, D; Huang, X; Li, G; Li, Y; Qi, X; Wang, X1
Brudney, CS; Ehieli, E; Pyati, S; Yalamuri, S1
Burns, J; Finkel, JC; Jackson, K; Quezado, ZM; Sheehy, KA1
Fujino, Y; Hirao, O; Mashimo, T; Ohashi, Y; Ohta, N; Uchiyama, A1
Christianson, CA; Hua, XY; Nazarian, A; Yaksh, TL1
Dupont, WD; Friedman, EA; Harris, PA; Kohli, U; Kurnik, D; Muszkat, M; Scheinin, M; Sofowora, GG; Stein, CM; Wood, AJ1
Bilge, SS; Bostanci, MO; Bozkurt, A; Ciftcioglu, E; Dilek, A; Güldogus, F; Ilkaya, F; Ulger, F1
Kohase, H; Makino, K; Sanada, T; Umino, M1
Bilgin, F; Cosar, A; Isik, S; Ozturk, S; Zor, F1
Kimura, T; Masaki, Y; Nishikawa, T; Sato, K; Tobe, Y1
Budak, ET; Dagli, G; Dere, K; Filiz, AI; Ozkan, S; Sucullu, I; Yeyen, S1
Boehm, CA; Carney, EL; Tallarida, RJ; Wilson, RP1
Anger, KE; Baroletti, SA; Fanikos, J; Labreche, MJ; Szumita, PM1
Allegaert, K; Thewissen, L1
Kanai, T; Maruta, T; Nemoto, T; Satoh, S; Tsuneyoshi, I; Wada, A; Yanagita, T1
Davis, J; Reimer, EJ; Whyte, E; Whyte, S; Winton, P1
Sezer, G; Sezer, Z; Tekol, Y1
Fukusaki, M; Higashijima, U; Ichinomiya, T; Miura, K; Sumikawa, K; Tanise, T; Terao, Y1
Arendt-Nielsen, L; Baba, Y; Fujii-Abe, K; Kohase, H; Oono, Y1
Bruce, W; Compton, J; Fonder, H; Garrett, N1
Bratty, JR; Garratt, C; Grounds, RM; Jakob, SM; Pocock, SJ; Ruokonen, E; Sarapohja, T; Takala, J1
Aydogan, MS; Durmus, M; Erdogan, MA; Kurt, A; Parlakpinar, H; Ucar, M; Yucel, A1
de Moura, RS; Fernandes, PD; Lessa, MA; Marinho, BG; Rangel, RA1
Anger, KE1
Halttunen, J; Kylänpää, L; Lindström, O; Mazanikov, M; Mustonen, H; Pöyhiä, R; Udd, M1
Serlin, S1
Taiji, K1
Angus, JA; Tham, SM; Tudor, EM; Wright, CE1
Karamanlioglu, B; Kaya, G; Memis, D; Seker, S; Turan, A1
Karamanlioglu, B; Kaya, G; Memis, D; Turan, A1
Ishio, E; Iwasaki, H; Kunisawa, T; Nagata, O; Ogasawara, H; Takahata, O1
Bagcivan, I; Cetin, A; Gulturk, S; Gursoy, S; Karadas, B; Kaya, T; Parlak, A1
Boyaci, A; Gulcu, N; Ugur, F1
Altunkaya, H; Ayoğlu, H; Cukdar, G; Ozer, Y; Ozkoçak, I; Yapakçi, O1
Fitzgerald, M; Walker, SM1
Leitch, J; Macpherson, A1
Yaksh, TL1
Apaydin, S; Guneli, E; Karabay Yavasoglu, NU; Uyar, M1
Dickey, S; Gadiraju, S; Galli, R; Lerant, AA; Phillips, WJ1
Adanir, T; Konakci, S; Rezanko, T; Yilmaz, G1
Slingsby, LS; Taylor, PM1
Pertovaara, A; Wei, H1
Kalso, E; Kontinen, VK; Xu, M1
Basbaum, AI; Hedley, LR; Hunter, JC; Jasper, JR; Malmberg, AB1
Ben-Abraham, R; Weinbroum, AA1

Reviews

17 review(s) available for dexmedetomidine and Pain

ArticleYear
The Effect of Dexmedetomidine on Postanesthesia Care Unit Discharge and Recovery: A Systematic Review and Meta-Analysis.
    Anesthesia and analgesia, 2022, 06-01, Volume: 134, Issue:6

    Topics: Adult; Anesthesia, General; Bradycardia; Cough; Dexmedetomidine; Emergence Delirium; Humans; Hypotension; Pain; Patient Discharge; Postoperative Nausea and Vomiting

2022
Sedation and analgesia from prolonged pain and stress during mechanical ventilation in preterm infants: is dexmedetomidine an alternative to current practice?
    BMJ paediatrics open, 2022, Volume: 6, Issue:1

    Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Dexmedetomidine; Humans; Infant, Newborn; Infant, Premature; Pain; Pain Management; Respiration, Artificial; Respiratory Insufficiency

2022
Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.
    The Cochrane database of systematic reviews, 2022, 11-10, Volume: 11

    Topics: Clonidine; Dexmedetomidine; Humans; Hypothermia, Induced; Infant, Newborn; Morphine Derivatives; Observational Studies as Topic; Pain

2022
Modern Sedation and Analgesia Strategies in Neurocritical Care.
    Current neurology and neuroscience reports, 2023, Volume: 23, Issue:4

    Topics: Analgesia; Critical Care; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Propofol; Respiration, Artificial

2023
The effect of adjuvants added to local anaesthetics for single-injection upper extremity peripheral regional anaesthesia: A systematic review with network meta-analysis of randomised trials.
    European journal of anaesthesiology, 2023, 09-01, Volume: 40, Issue:9

    Topics: Anesthesia, Conduction; Anesthetics, Local; Dexamethasone; Dexmedetomidine; Humans; Ketorolac; Midazolam; Network Meta-Analysis; Pain; Randomized Controlled Trials as Topic; Upper Extremity

2023
Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.
    Clinics in perinatology, 2019, Volume: 46, Issue:4

    Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clonidine; Combined Modality Therapy; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Infant, Newborn; Intensive Care Units, Neonatal; Midazolam; Morphine; Pain; Pain Management; Pharmacogenomic Variants; Precision Medicine; Remifentanil

2019
The influence of pain, agitation, and their management on the immature brain.
    Pediatric research, 2020, Volume: 88, Issue:2

    Topics: Algorithms; Analgesics, Opioid; Brain; Chronic Pain; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Morphine; Neuroimaging; Pain; Pain Management; Remifentanil; Respiration, Artificial; Stress, Psychological; Sucrose

2020
Dexmedetomidine for prevention of propofol injection pain upon induction of anesthesia: a meta-analysis.
    European journal of clinical pharmacology, 2020, Volume: 76, Issue:8

    Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Intravenous; Dexmedetomidine; Humans; Pain; Propofol; Randomized Controlled Trials as Topic

2020
Risks and benefits of pre-operative dexmedetomidine in oral and maxillofacial surgeries: a systematic review.
    Expert opinion on drug safety, 2017, Volume: 16, Issue:6

    Topics: Anxiety; Dexmedetomidine; Humans; Hypnotics and Sedatives; Oral Surgical Procedures; Pain; Preoperative Care; Randomized Controlled Trials as Topic

2017
Intra-articular dexmedetomidine in knee arthroscopy: A systematic review and meta-analysis.
    Scientific reports, 2018, 03-06, Volume: 8, Issue:1

    Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Arthroscopy; Dexmedetomidine; Female; Humans; Knee; Male; Pain; Randomized Controlled Trials as Topic; Treatment Outcome

2018
Use of dexmedetomidine in pediatric cardiac anesthesia.
    Current opinion in anaesthesiology, 2019, Volume: 32, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Cardiac Procedures; Cardiac Surgical Procedures; Child; Dexmedetomidine; Heart; Humans; Kidney; Nervous System; Pain; Randomized Controlled Trials as Topic; Treatment Outcome

2019
A meta-analysis of analgesic and sedative effects of dexmedetomidine in burn patients.
    Burns : journal of the International Society for Burn Injuries, 2013, Volume: 39, Issue:4

    Topics: Analgesics, Non-Narcotic; Burns; Conscious Sedation; Dexmedetomidine; Humans; Hypnotics and Sedatives; Pain

2013
Analgesia in the surgical intensive care unit.
    Postgraduate medical journal, 2017, Volume: 93, Issue:1095

    Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Conduction; Anesthetics, Local; Clonidine; Critical Care; Cyclohexanecarboxylic Acids; Dexmedetomidine; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Humans; Hydromorphone; Intensive Care Units; Ketamine; Lidocaine; Morphine; Pain; Pain Management; Pain Measurement; Pain, Postoperative; Physical Therapy Modalities

2017
Analgosedation in neonates: do we still need additional tools after 30 years of clinical research?
    Archives of disease in childhood. Education and practice edition, 2011, Volume: 96, Issue:3

    Topics: Acetaminophen; Adrenergic alpha-2 Receptor Agonists; Analgesia; Analgesics, Opioid; Dexmedetomidine; Humans; Hypnotics and Sedatives; Infant, Newborn; Midazolam; Morphine; Pain; Pain Measurement; Piperidines; Propofol; Quality of Health Care; Remifentanil

2011
Dexmedetomidine: a review of its use for the management of pain, agitation, and delirium in the intensive care unit.
    Current pharmaceutical design, 2013, Volume: 19, Issue:22

    Topics: Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Pain Management; Psychomotor Agitation

2013
[Dexmedetomidine hydrochloride (Precedex), a new sedative in intensive care, its pharmacological characteristics and clinical study result].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2004, Volume: 124, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Critical Care; Dexmedetomidine; Dose-Response Relationship, Drug; Escape Reaction; Humans; Hypnotics and Sedatives; Locus Coeruleus; Mice; Motor Activity; Multicenter Studies as Topic; Pain; Rats

2004
Dextromethorphan and dexmedetomidine: new agents for the control of perioperative pain.
    The European journal of surgery = Acta chirurgica, 2001, Volume: 167, Issue:8

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Dexmedetomidine; Dextromethorphan; Humans; N-Methylaspartate; Pain; Pain, Postoperative; Premedication; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate

2001

Trials

53 trial(s) available for dexmedetomidine and Pain

ArticleYear
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:8

    Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives; Hypotension; Ketamine; Pain; Propofol; Prospective Studies

2022
Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT).
    Journal of bronchology & interventional pulmonology, 2022, Oct-01, Volume: 29, Issue:4

    Topics: Analgesics, Opioid; Conscious Sedation; Cough; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Midazolam; Pain; Pilot Projects; Thoracoscopy

2022
Efficacy of adding dexmedetomidine to lidocaine to enhance inferior alveolar nerve block in patients with asymptomatic irreversible pulpitis: double-blind randomized clinical trial.
    Clinical oral investigations, 2022, Volume: 26, Issue:7

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Humans; Lidocaine; Mandibular Nerve; Nerve Block; Pain; Pulpitis

2022
Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes.
    BMC anesthesiology, 2022, 03-28, Volume: 22, Issue:1

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anxiety; Dexmedetomidine; Female; Fentanyl; Genotype; Humans; Pain; Pregnancy

2022
A Comparative Study on Sedation Efficacy Between General and Regional Anesthesia with Dexmedetomidine in Patients Under Maxillofacial Surgery.
    Current drug metabolism, 2022, Volume: 23, Issue:11

    Topics: Adult; Anesthesia, Conduction; Anesthesia, General; Dexmedetomidine; Humans; Middle Aged; Pain; Surgery, Oral; Young Adult

2022
Comparison of the efficacy and safety of sedation protocols with the use of dexmedetomidine-remifentanil and propofol-remifentanil during percutaneous closure of atrial septal defects: a randomized clinical trial.
    Journal of cardiothoracic surgery, 2022, May-03, Volume: 17, Issue:1

    Topics: Clinical Protocols; Dexmedetomidine; Drug Combinations; Heart Septal Defects, Atrial; Humans; Hypercapnia; Hypnotics and Sedatives; Pain; Propofol; Remifentanil; Treatment Outcome

2022
Efficacy and safety of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine for epidural labor analgesia: a randomized controlled trial.
    Annals of palliative medicine, 2022, Volume: 11, Issue:4

    Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Anesthetics, Local; Dexmedetomidine; Female; Humans; Infant, Newborn; Pain; Ropivacaine; Sufentanil

2022
Effect of intratracheal dexmedetomidine combined with ropivacaine on postoperative sore throat: a prospective randomised double-blinded controlled trial.
    BMC anesthesiology, 2022, 05-14, Volume: 22, Issue:1

    Topics: Dexmedetomidine; Humans; Intubation, Intratracheal; Pain; Pharyngitis; Postoperative Complications; Prospective Studies; Ropivacaine

2022
Effect of dexmedetomidine administration on analgesic, respiration and inflammatory responses in patients undergoing percutaneous endoscopic lumbar discectomy: a prospective observational study.
    BMC anesthesiology, 2022, 05-18, Volume: 22, Issue:1

    Topics: Adult; Analgesics; Dexmedetomidine; Diskectomy; Diskectomy, Percutaneous; Endoscopy; Humans; Inflammation; Interleukin-6; Intervertebral Disc Displacement; Lumbar Vertebrae; Pain; Respiration; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha

2022
Analgesic Characteristics of Bupivacaine Alone and in Combination with Dexmedetomidine or Meperidine in Spinal Anesthesia during Cesarean Section: A Double-Blind Randomized Clinical Trial Study.
    Pain research & management, 2022, Volume: 2022

    Topics: Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Dexmedetomidine; Double-Blind Method; Female; Humans; Injections, Spinal; Meperidine; Pain; Pregnancy

2022
Optimal Dose of Dexmedetomidine for Preemptive Analgesia Combined with Transversus Abdominis Plane Block after Colon Cancer Surgery.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2022, Volume: 89, Issue:4

    Topics: Abdominal Muscles; Analgesia; Anesthetics, Local; Colonic Neoplasms; Dexmedetomidine; Double-Blind Method; Humans; Pain; Pain, Postoperative; Prospective Studies; Ropivacaine

2022
Ketamine and dexmedetomidine (Keto-dex) or ketamine and propofol (Keto-fol) for procedural sedation during endoscopic retrograde cholangiopancreatography: Which is safer? A randomized clinical trial.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2022, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dexmedetomidine; Humans; Hypnotics and Sedatives; Ketamine; Middle Aged; Pain; Propofol; Prospective Studies; Young Adult

2022
Real-time evaluation of the independent analgesic efficacy of dexmedetomidine.
    BMC anesthesiology, 2023, 03-04, Volume: 23, Issue:1

    Topics: Analgesia; Analgesics; Dexmedetomidine; Humans; Midazolam; Pain

2023
Effect of Different Administration Routes of Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Elective Spinal Surgery: A Prospective Randomized Double-Blinded Controlled Trial.
    Anesthesia and analgesia, 2023, 06-01, Volume: 136, Issue:6

    Topics: Aged; Anesthesia, General; Delirium; Dexmedetomidine; Double-Blind Method; Emergence Delirium; Humans; Pain; Prospective Studies

2023
Intranasal Dexmedetomidine for Pain Management in Older Patients: A Cross-Over, Randomized, Double-Blinded, Active-Controlled Trial.
    Drugs & aging, 2023, Volume: 40, Issue:6

    Topics: Administration, Intranasal; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Pain; Pain Management

2023
Single-bolus dexmedetomidine in prevention of emergence delirium in pediatric ophthalmic surgeries: A randomized controlled trial.
    Indian journal of ophthalmology, 2023, Volume: 71, Issue:5

    Topics: Blood Pressure; Child; Dexmedetomidine; Double-Blind Method; Emergence Delirium; Humans; Pain; Postoperative Complications

2023
Effect of different modes of administration of dexmedetomidine on the quality of recovery in ambulatory thyroidectomy: a randomized, controlled trial.
    The Journal of international medical research, 2023, Volume: 51, Issue:5

    Topics: Adjuvants, Immunologic; Dexmedetomidine; Humans; Pain; Ropivacaine; Thyroidectomy

2023
Low-dose intranasal dexmedetomidine premedication improves epidural labor analgesia onset and reduces procedural pain on epidural puncture: a prospective randomized double-blind clinical study.
    BMC anesthesiology, 2023, 05-30, Volume: 23, Issue:1

    Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Female; Humans; Infant, Newborn; Pain; Pain Management; Pain, Procedural; Prospective Studies; Punctures; Ropivacaine; Sufentanil

2023
Dexmedetomidine versus haloperidol for sedation of non-intubated patients with hyperactive delirium during the night in a high dependency unit: study protocol for an open-label, parallel-group, randomized controlled trial (DEX-HD trial).
    BMC anesthesiology, 2023, 06-03, Volume: 23, Issue:1

    Topics: Critical Illness; Delirium; Dexmedetomidine; Drugs, Investigational; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Psychomotor Agitation; Randomized Controlled Trials as Topic

2023
Effect of interscalene brachial plexus block with dexmedetomidine and ropivacaine on postoperative analgesia in patients undergoing arthroscopic shoulder surgery: a randomized controlled clinical trial.
    Trials, 2023, Jun-12, Volume: 24, Issue:1

    Topics: Adult; Analgesia; Brachial Plexus Block; Dexmedetomidine; Humans; Pain; Ropivacaine; Shoulder; Sufentanil

2023
Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine.
    Paediatric anaesthesia, 2023, Volume: 33, Issue:11

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; Child; Child, Preschool; Clonidine; Dexmedetomidine; Double-Blind Method; Emergence Delirium; Humans; Hypnotics and Sedatives; Midazolam; Pain; Premedication

2023
Dexamethasone and dexmedetomidine as adjuvants to ropivacaine do not prolong analgesia in wound infiltration for lumbar spinal fusion: a prospective randomized controlled study.
    Journal of orthopaedic surgery and research, 2023, Sep-04, Volume: 18, Issue:1

    Topics: Adult; Agnosia; Analgesia; Analgesics, Opioid; Dexamethasone; Dexmedetomidine; Humans; Hydromorphone; Lumbar Vertebrae; Pain; Prospective Studies; Ropivacaine; Spinal Fusion

2023
A comparative study of esketamine-dexmedetomidine and sufentanil-dexmedetomidine for sedation and analgesia in lung tumor percutaneous radiofrequency ablation (PRFA): a randomized double-blind clinical trial.
    BMC anesthesiology, 2023, 09-08, Volume: 23, Issue:1

    Topics: Aged; Analgesia; Anesthesia; Dexmedetomidine; Humans; Lung Neoplasms; Pain; Sufentanil

2023
Clinical effects of epidurally administered dexmedetomidine with or without lidocaine in sheep.
    The Veterinary record, 2020, 05-16, Volume: 186, Issue:16

    Topics: Anesthetics, Local; Animals; Blood Pressure; Dexmedetomidine; Drug Combinations; Female; Heart Rate; Hypnotics and Sedatives; Injections, Epidural; Lidocaine; Male; Pain; Respiratory Rate; Sheep

2020
A randomized double-blind controlled trial comparing three sedation regimens during flexible bronchoscopy: Dexmedetomidine, alfentanil and lidocaine.
    The clinical respiratory journal, 2018, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Alfentanil; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Bronchoscopy; Conscious Sedation; Dexmedetomidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Pain; Pain Measurement; Retrospective Studies; Young Adult

2018
Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study.
    Journal of anesthesia, 2018, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Analgesics; Dexmedetomidine; Double-Blind Method; Electroconvulsive Therapy; Female; Humans; Hypnotics and Sedatives; Male; Pain; Pain Measurement; Propofol; Young Adult

2018
Letting the Patient Decide: A Case Report of Self-Administered Sedation During Mechanical Ventilation.
    Critical care nurse, 2018, Volume: 38, Issue:1

    Topics: Dexmedetomidine; Education, Nursing, Continuing; Female; Humans; Hypnotics and Sedatives; Middle Aged; Pain; Patient Participation; Patient Satisfaction; Pilots; Respiration, Artificial; Self Administration; Treatment Outcome

2018
Analgesic effect of Ropivacaine combined with Dexmedetomidine on brachial plexus block.
    BMC anesthesiology, 2018, 08-16, Volume: 18, Issue:1

    Topics: Adult; Analgesics, Non-Narcotic; Brachial Plexus Block; Dexmedetomidine; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male; Middle Aged; Oxygen; Pain; Ropivacaine; Time Factors; Visual Analog Scale; Young Adult

2018
[Comparison between Dexmedetomidine and Fentanyl Infusion during Fetoscopic Laser Photocoagulation for Twin to Twin Transfusion Syndrome].
    Masui. The Japanese journal of anesthesiology, 2017, Volume: 66, Issue:3

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Dexmedetomidine; Female; Fentanyl; Fetofetal Transfusion; Humans; Lidocaine; Light Coagulation; Pain; Pain Management; Pregnancy; Prospective Studies

2017
Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Female; Humans; Labor, Obstetric; Pain; Pain Measurement; Pregnancy; Prospective Studies; Sufentanil; Young Adult

2019
Thermal antinociceptive, sedative and cardiovascular effects of Governing Vessel 1 dexmedetomidine pharmacopuncture in healthy cats.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:4

    Topics: Acupuncture Analgesia; Animals; Cats; Conscious Sedation; Cross-Over Studies; Dexmedetomidine; Female; Heart Rate; Hot Temperature; Muscle Relaxation; Pain; Random Allocation; Respiration; Skin Temperature

2019
Effects of isoflurane with and without dexmedetomidine or remifentanil on heart rate variability before and after nociceptive stimulation at different multiples of minimum alveolar concentration in dogs.
    American journal of veterinary research, 2013, Volume: 74, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cross-Over Studies; Dexmedetomidine; Dogs; Drug Therapy, Combination; Female; Heart Rate; Isoflurane; Male; Pain; Piperidines; Pulmonary Alveoli; Remifentanil

2013
Comparison of the efficacy of dexmedetomidine plus fentanyl patient-controlled analgesia with fentanyl patient-controlled analgesia for pain control in uterine artery embolization for symptomatic fibroid tumors or adenomyosis: a prospective, randomized st
    Journal of vascular and interventional radiology : JVIR, 2013, Volume: 24, Issue:6

    Topics: Adenomyosis; Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Chemoembolization, Therapeutic; Dexmedetomidine; Drug Therapy, Combination; Female; Fentanyl; Humans; Leiomyoma; Pain; Pain Measurement; Premedication; Prospective Studies; Self Administration; Treatment Outcome; Uterine Artery Embolization; Uterine Neoplasms

2013
Sedative and antinociceptive effects of dexmedetomidine and buprenorphine after oral transmucosal or intramuscular administration in cats.
    Veterinary anaesthesia and analgesia, 2014, Volume: 41, Issue:1

    Topics: Administration, Mucosal; Analgesics; Animals; Buprenorphine; Cat Diseases; Cats; Dexmedetomidine; Drug Therapy, Combination; Female; Hypnotics and Sedatives; Injections, Intramuscular; Pain

2014
Preemptive dexmedetomidine to prevent propofol injection pain in children.
    Irish journal of medical science, 2015, Volume: 184, Issue:2

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Child; Child, Preschool; Dexmedetomidine; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Lidocaine; Male; Midazolam; Pain; Pain Measurement; Propofol

2015
Dexmedetomidine reduces pain associated with rocuronium injection without causing a decrease in BIS values: a dose-response study.
    Journal of clinical anesthesia, 2014, Volume: 26, Issue:6

    Topics: Adult; Analgesics, Non-Narcotic; Androstanols; Anesthesia, General; Dexmedetomidine; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Female; Humans; Injections, Intravenous; Male; Middle Aged; Monitoring, Intraoperative; Neuromuscular Nondepolarizing Agents; Pain; Pain Measurement; Premedication; Propofol; Rocuronium; Young Adult

2014
Dexmedetomidine pretreatment alleviates propofol injection pain.
    Upsala journal of medical sciences, 2014, Volume: 119, Issue:4

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Dexmedetomidine; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Propofol; Prospective Studies; Triglycerides; Young Adult

2014
[Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation].
    Zhonghua yi xue za zhi, 2014, Nov-11, Volume: 94, Issue:41

    Topics: Aged; Analgesics; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Postoperative Care; Postoperative Period; Propofol; Respiration, Artificial; Time Factors

2014
Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Adult; Analgesics, Non-Narcotic; Dental Implants; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypnotics and Sedatives; Inflammation; Interleukin-6; Male; Malondialdehyde; Midazolam; Middle Aged; Oxidative Stress; Pain; Postoperative Complications; Severity of Illness Index; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2015
[Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit].
    Zhonghua wei zhong bing ji jiu yi xue, 2016, Volume: 28, Issue:1

    Topics: Analgesics; Circadian Rhythm; Critical Care; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Propofol; Prospective Studies; Respiration, Artificial

2016
[A study of using dexmedetomidine in ventilator bundle treatment in an ICU].
    Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:10

    Topics: Arterial Pressure; Blood Pressure; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of Stay; Midazolam; Pain; Prospective Studies; Respiration, Artificial; Single-Blind Method

2015
[The influence of the sedation based on remifentanil analgesia on the occurrence of delirium in critically ill patients].
    Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:10

    Topics: Analgesia; Arterial Pressure; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Kaplan-Meier Estimate; Midazolam; Pain; Piperidines; Prospective Studies; Remifentanil; Respiration, Artificial

2015
[Analgesic and Sedative Effect of Acupuncture Combined with Medicine on Patients Undergiong Cardiac Surgery].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2016, Volume: 36, Issue:3

    Topics: Acupuncture Analgesia; Analgesia; Analgesics; Cardiac Surgical Procedures; Dexmedetomidine; Electroacupuncture; Heart Rate; Humans; Hypnotics and Sedatives; Morphine; Pain; Pain Management; Respiration, Artificial

2016
Comparison of Intrathecal Dexmedetomidine with Morphine as Adjuvants in Cesarean Sections.
    Biological & pharmaceutical bulletin, 2016, Sep-01, Volume: 39, Issue:9

    Topics: Adjuvants, Pharmaceutic; Adult; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Injections, Spinal; Morphine; Pain; Pregnancy; Pruritus; Shivering

2016
Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine.
    Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:4

    Topics: Adult; Analgesics; Bandages; Blood Pressure; Burns; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypnotics and Sedatives; Ketamine; Male; Midazolam; Middle Aged; Pain; Pain Measurement; Patient Satisfaction; Respiration; Tramadol; Young Adult

2010
A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:7

    Topics: Adult; Aged; Analgesics; Analgesics, Opioid; Colonoscopy; Conscious Sedation; Consciousness; Dexmedetomidine; Double-Blind Method; Female; Fentanyl; Hemodynamics; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male; Midazolam; Middle Aged; Pain; Pain Measurement; Patient Satisfaction; Prospective Studies; Recovery of Function; Surveys and Questionnaires; Time Factors

2010
Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery.
    Journal of anesthesia, 2012, Volume: 26, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Atropine; Blood Pressure; Cervical Vertebrae; Dexmedetomidine; Dopamine; Female; Heart Rate; Humans; Hypnotics and Sedatives; Intubation, Intratracheal; Male; Middle Aged; Movement; Pain; Postoperative Care; Propofol

2012
Effects of dexmedetomidine on conditioned pain modulation in humans.
    European journal of pain (London, England), 2012, Volume: 16, Issue:8

    Topics: Adult; Analgesics, Non-Narcotic; Cerebral Cortex; Conditioning, Psychological; Dexmedetomidine; Double-Blind Method; Electric Stimulation; Evoked Potentials, Somatosensory; Female; Humans; Male; Pain; Pain Measurement; Tooth

2012
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
    JAMA, 2012, Mar-21, Volume: 307, Issue:11

    Topics: Aged; Communication; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Length of Stay; Male; Midazolam; Middle Aged; Nurse-Patient Relations; Pain; Pain Measurement; Propofol; Respiration, Artificial; Time Factors

2012
Dexmedetomidine impairs success of patient-controlled sedation in alcoholics during ERCP: a randomized, double-blind, placebo-controlled study.
    Surgical endoscopy, 2013, Volume: 27, Issue:6

    Topics: Alcoholism; Alfentanil; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Male; Middle Aged; Pain; Patient Satisfaction; Propofol; Prospective Studies

2013
Preventing pain on injection of rocuronium: two doses of dexmedetomidine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2005, Volume: 52, Issue:4

    Topics: Adrenergic alpha-Agonists; Androstanols; Dexmedetomidine; Humans; Injections, Intravenous; Neuromuscular Nondepolarizing Agents; Pain; Rocuronium

2005
Does dexmedetomidine reduce the injection pain due to propofol and rocuronium?
    European journal of anaesthesiology, 2007, Volume: 24, Issue:6

    Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Androstanols; Anesthesia, Intravenous; Dexmedetomidine; Double-Blind Method; Elective Surgical Procedures; Humans; Hypnotics and Sedatives; Injections, Intravenous; Middle Aged; Neuromuscular Nondepolarizing Agents; Pain; Pain Measurement; Preoperative Care; Propofol; Prospective Studies; Rocuronium

2007
Thermal antinociception after dexmedetomidine administration in cats: a dose-finding study.
    Journal of veterinary pharmacology and therapeutics, 2008, Volume: 31, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Cats; Cross-Over Studies; Dexmedetomidine; Female; Hot Temperature; Injections, Intramuscular; Male; Pain; Pain Measurement

2008

Other Studies

71 other study(ies) available for dexmedetomidine and Pain

ArticleYear
Changing Pain Management Strategy from Opioid-centric Towards Improve Postoperative Cognitive Dysfunction with Dexmedetomidine.
    Current drug metabolism, 2022, Volume: 23, Issue:1

    Topics: Adult; Analgesics, Opioid; Dexmedetomidine; Emergence Delirium; Femoral Neck Fractures; Humans; Pain; Pain Management; Postoperative Cognitive Complications

2022
Procedural Sedation With Dexmedetomidine in Combination With Ketamine in the Emergency Department.
    The Journal of emergency medicine, 2022, Volume: 63, Issue:2

    Topics: Anesthetics, Dissociative; Conscious Sedation; Dexmedetomidine; Drug Combinations; Emergency Service, Hospital; Humans; Hypnotics and Sedatives; Ketamine; Pain; Prospective Studies

2022
The feasibility and safety of cocktail treatment of triple anti-inflammatory agents loaded with gelatin sponge promotes early recovery after posterior percutaneous endoscopic cervical discectomy.
    Journal of orthopaedic surgery and research, 2022, May-26, Volume: 17, Issue:1

    Topics: Anti-Inflammatory Agents; Cervical Vertebrae; Dexamethasone; Dexmedetomidine; Diskectomy; Feasibility Studies; Gelatin; Humans; Pain; Retrospective Studies; Ropivacaine; Treatment Outcome; Vitamin B 12

2022
A sequential allocation study to determine the ED
    BMC anesthesiology, 2022, 05-27, Volume: 22, Issue:1

    Topics: Anesthesia, Conduction; Anesthetics, Local; Clonidine; Dexmedetomidine; Double-Blind Method; Humans; Lidocaine; Pain

2022
Effects of dezocine combined with dexmedetomidine on adverse reactions and inflammatory factors in patients undergoing HIPEC after intestinal surgery and its protective effect on the heart in the perioperative period.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:10

    Topics: Bridged Bicyclo Compounds, Heterocyclic; C-Reactive Protein; Dexmedetomidine; Digestive System Surgical Procedures; Humans; Hyperthermic Intraperitoneal Chemotherapy; Pain; Perioperative Period; Tetrahydronaphthalenes; Vascular Endothelial Growth Factor A

2022
Anesthetic Effect of Dexmedetomidine in Clinical Functional Neurosurgery.
    Disease markers, 2022, Volume: 2022

    Topics: Anesthetics; Dexmedetomidine; Humans; Neurosurgery; Neurosurgical Procedures; Pain

2022
Dexmedetomidine and Propofol at End of Life in Pediatric Oncology: Trends in Palliative Sedation Therapy.
    Journal of palliative medicine, 2023, Volume: 26, Issue:1

    Topics: Child; Death; Dexmedetomidine; Humans; Neoplasms; Pain; Palliative Care; Propofol; Prospective Studies; Terminal Care

2023
Structure-based discovery of nonopioid analgesics acting through the α
    Science (New York, N.Y.), 2022, 09-30, Volume: 377, Issue:6614

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Non-Narcotic; Animals; Dexmedetomidine; Drug Design; Drug Discovery; Humans; Ligands; Mice; Molecular Docking Simulation; Pain; Pain Management; Structure-Activity Relationship

2022
Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes.
    Neuroscience letters, 2022, 11-20, Volume: 791

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; AMP-Activated Protein Kinases; Animals; Astrocytes; Dexmedetomidine; Disease Models, Animal; Dopaminergic Neurons; Interleukin-6; Mice; Mice, Inbred C57BL; NF-kappa B; Pain; Parkinson Disease; Quality of Life; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2022
Novel Use of Intranasal Dexmedetomidine for Refractory Irritability in Pediatric Home Care.
    Journal of palliative medicine, 2023, Volume: 26, Issue:4

    Topics: Administration, Intranasal; Analgesics; Anesthesia; Child; Dexmedetomidine; Humans; Hypnotics and Sedatives; Male; Pain

2023
Tracheotomy in ventilator-dependent patients with COVID-19: a cross-sectional study of analgesia and sedative requirements.
    The Journal of international medical research, 2022, Volume: 50, Issue:11

    Topics: Analgesia; Analgesics; COVID-19; Cross-Sectional Studies; Dexmedetomidine; Humans; Hypnotics and Sedatives; Lorazepam; Morphine; Pain; Propofol; Retrospective Studies; Tracheotomy; Ventilators, Mechanical

2022
A comparative study of patient satisfaction about anesthesia with dexmedetomidine for ambulatory dental surgery.
    BMC research notes, 2022, Dec-22, Volume: 15, Issue:1

    Topics: Ambulatory Surgical Procedures; Anesthesia, General; Dexmedetomidine; Humans; Pain; Patient Satisfaction

2022
Impact of dexmedetomidine in conjunction with a weaning protocol on post-surgical opioid use in a neonatal intensive care unit.
    Pharmacotherapy, 2023, Volume: 43, Issue:7

    Topics: Acetaminophen; Analgesics, Opioid; Clonidine; Dexmedetomidine; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Opioid-Related Disorders; Pain; Retrospective Studies; Weaning

2023
Dexmedetomidine alleviates osteoarthritis inflammation and pain through the CB
    International immunopharmacology, 2023, Volume: 119

    Topics: Animals; Dexmedetomidine; Inflammation; Osteoarthritis; Pain; Rats; Synovial Membrane

2023
Long-duration upper extremity surgery under brachial plexus block combined with intravenous dexmedetomidine sedation without an anesthesiologist.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2023, Volume: 84

    Topics: Anesthesia; Anesthesiologists; Brachial Plexus Block; Dexmedetomidine; Humans; Pain; Retrospective Studies; Upper Extremity

2023
Clinical efficacy of sufentanil combined with dexmedetomidine in patient-controlled subcutaneous analgesia for advanced cancer pain.
    Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:3(Special)

    Topics: Analgesia, Patient-Controlled; Cancer Pain; Dexmedetomidine; Humans; Neoplasms; Pain; Sufentanil; Treatment Outcome

2023
The risks of sedation and pain control during burn resuscitation: Increased opioids lead to over-resuscitation and hypotension.
    Burns : journal of the International Society for Burn Injuries, 2023, Volume: 49, Issue:7

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Burns; Dexmedetomidine; Fluid Therapy; Humans; Hypnotics and Sedatives; Hypotension; Middle Aged; Pain; Pain Management; Propofol; Resuscitation; Retrospective Studies

2023
Uterine Artery Embolization for Leiomyomas and Adenomyosis: A Pictorial Essay Based on Our Experience from 1300 Cases.
    Korean journal of radiology, 2019, Volume: 20, Issue:10

    Topics: Adenomyosis; Adult; Angiography; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Leiomyoma; Magnetic Resonance Imaging; Middle Aged; Pain; Treatment Outcome; Uterine Artery Embolization; Uterine Neoplasms; Uterus

2019
Dexmedetomidine for dyspnoea.
    BMJ supportive & palliative care, 2023, Volume: 13, Issue:e1

    Topics: Dexmedetomidine; Dyspnea; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain

2023
Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium.
    The Annals of pharmacotherapy, 2021, Volume: 55, Issue:2

    Topics: Adjuvants, Pharmaceutic; Adult; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Delirium; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Male; Middle Aged; Pain; Propofol; Quetiapine Fumarate; Respiration, Artificial; Retrospective Studies

2021
Feasibility of Intranasal Dexmedetomidine in Treatment of Postoperative Restlessness, Agitation, and Pain in Geriatric Orthopedic Patients.
    Drugs & aging, 2021, Volume: 38, Issue:5

    Topics: Aged; Aged, 80 and over; Dexmedetomidine; Feasibility Studies; Humans; Pain; Psychomotor Agitation; Retrospective Studies

2021
Evaluation of Dexmedetomidine Dosing in Obese Critically Ill Patients.
    Journal of pharmacy practice, 2023, Volume: 36, Issue:1

    Topics: Adolescent; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Pain; Respiration, Artificial

2023
Dexmedetomidine relieves formaldehyde-induced pain in rats through both α2 adrenoceptor and imidazoline receptor.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90

    Topics: Animals; Dexmedetomidine; Formaldehyde; Imidazoline Receptors; Male; Nitric Oxide Synthase Type I; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, G-Protein-Coupled; Signal Transduction

2017
A National Multicenter Survey on Management of Pain, Agitation, and Delirium in Intensive Care Units in China.
    Chinese medical journal, 2017, May-20, Volume: 130, Issue:10

    Topics: Delirium; Dexmedetomidine; Fentanyl; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Pain; Pain Management; Pain Measurement; Surveys and Questionnaires

2017
Dexmedetomidine prolongs levobupivacaine analgesia via inhibition of inflammation and p38 MAPK phosphorylation in rat dorsal root ganglion.
    Neuroscience, 2017, Oct-11, Volume: 361

    Topics: Animals; Bupivacaine; Dexmedetomidine; Ganglia, Spinal; Inflammation; Levobupivacaine; Male; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pain; Pain Management; Phosphorylation; Rats, Sprague-Dawley

2017
[The impact of goal directed analgesia on mechanical ventilated patients's outcomes in intensive care unit: a clinical observational study].
    Zhonghua nei ke za zhi, 2017, Nov-01, Volume: 56, Issue:11

    Topics: Analgesia; China; Critical Care; Delirium; Dexmedetomidine; Drug Administration Schedule; Goals; Humans; Hypnotics and Sedatives; Incidence; Intensive Care Units; Length of Stay; Methohexital; Midazolam; Outcome and Process Assessment, Health Care; Pain; Psychomotor Agitation; Respiration, Artificial; Ventilators, Mechanical

2017
Use of dexmedetomidine in a cardiac intensive care unit.
    Journal of clinical anesthesia, 2018, Volume: 44

    Topics: Aged; Aged, 80 and over; Critical Care; Delirium; Dexmedetomidine; Drug Utilization; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Male; Middle Aged; Pain; Prospective Studies; Psychomotor Agitation

2018
Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit.
    Clinical drug investigation, 2018, Volume: 38, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Critical Care; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Male; Midazolam; Middle Aged; Pain; Propofol; Quality of Life; Respiration, Artificial; Retrospective Studies; Stress Disorders, Post-Traumatic; Sweden; Ventilator Weaning; Young Adult

2018
Blind method regarding the effect of dexmedetomidine on CRBD.
    Journal of anesthesia, 2018, Volume: 32, Issue:3

    Topics: Dexmedetomidine; Humans; Pain; Postoperative Period; Urinary Bladder; Urinary Catheters

2018
Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:5(Special)

    Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Anesthesia, General; Delirium; Dexmedetomidine; Female; Hip Fractures; Humans; Hypnotics and Sedatives; Incidence; Male; Middle Aged; Neuroprotective Agents; Pain; Postoperative Complications; Propofol

2018
Evaluation of analgesic interaction between morphine, dexmedetomidine and maropitant using hot-plate and tail-flick tests in rats.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:4

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antiemetics; Dexmedetomidine; Drug Synergism; Drug Therapy, Combination; Male; Morphine; Pain; Pain Measurement; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley

2019
Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation.
    Journal of critical care, 2019, Volume: 53

    Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Attitude of Health Personnel; Benzodiazepines; Critical Care; Cross-Sectional Studies; Deep Sedation; Delirium; Dexmedetomidine; Extracorporeal Membrane Oxygenation; Fentanyl; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pain; Perception; Professional Practice; Propofol; Psychomotor Agitation; Respiratory Insufficiency

2019
Molecular mechanisms underlying the analgesic property of intrathecal dexmedetomidine and its neurotoxicity evaluation: an in vivo and in vitro experimental study.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Analgesics; Animals; Blotting, Western; Dexmedetomidine; Immunohistochemistry; In Vitro Techniques; Injections, Spinal; Male; Mice; Nervous System; Pain

2013
The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice.
    International journal of medical sciences, 2014, Volume: 11, Issue:3

    Topics: Analgesics; Animals; Dexmedetomidine; Formaldehyde; Immunity; Interleukin-10; Killer Cells, Natural; Lymphocytes; Mice; Pain; Spleen

2014
Dexmedetomidine #280.
    Journal of palliative medicine, 2014, Volume: 17, Issue:6

    Topics: Administration, Intravenous; Conscious Sedation; Costs and Cost Analysis; Dexmedetomidine; Humans; Hypnotics and Sedatives; Pain; Pain Management; Respiration, Artificial; Terminal Care

2014
Dexmedetomidine produced analgesic effect via inhibition of HCN currents.
    European journal of pharmacology, 2014, Oct-05, Volume: 740

    Topics: Analgesics, Non-Narcotic; Animals; Dexmedetomidine; HEK293 Cells; Hot Temperature; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice, Inbred C57BL; Mice, Knockout; Pain; Potassium Channels

2014
Prepubertal gonadectomy in cats: different injectable anaesthetic combinations and comparison with gonadectomy at traditional age.
    Journal of feline medicine and surgery, 2015, Volume: 17, Issue:6

    Topics: Anesthesia; Anesthetics; Animals; Buprenorphine; Cats; Dexmedetomidine; Female; Injections, Intramuscular; Ketamine; Medetomidine; Orchiectomy; Ovariectomy; Pain; Random Allocation; Sexual Maturation

2015
Dexmedetomidine and hydromorphone: a novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Antibodies, Monoclonal; Child; Child, Preschool; Dexmedetomidine; Drug Therapy, Combination; Female; Follow-Up Studies; Gangliosides; Humans; Hydromorphone; Immunotherapy; Male; Neuroblastoma; Pain; Pain Management; Prognosis

2015
Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice.
    European journal of pharmacology, 2015, May-05, Volume: 754

    Topics: Adrenergic alpha-2 Receptor Agonists; Anemia, Sickle Cell; Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Hand Strength; Humans; Hypnotics and Sedatives; Mice; Mice, Transgenic; Pain; Pain Measurement; Vocalization, Animal; Wakefulness

2015
Dexmedetomidine as an Adjuvant to Analgesic Strategy During Vaso-Occlusive Episodes in Adolescents with Sickle-Cell Disease.
    Pain practice : the official journal of World Institute of Pain, 2015, Volume: 15, Issue:8

    Topics: Adolescent; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Dexmedetomidine; Female; Humans; Infusions, Intravenous; Male; Pain; Pain Management; Pain Measurement

2015
The Use of Dexmedetomidine in Pediatric Palliative Care: A Preliminary Study.
    Journal of palliative medicine, 2017, Volume: 20, Issue:7

    Topics: Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Cohort Studies; Dexmedetomidine; Female; Heart Diseases; Humans; Hypnotics and Sedatives; Infant; Male; Pain; Palliative Care

2017
Analgesic effect of dexmedetomidine in a patient with herpetic stomatitis after living-donor lung transplantation.
    Journal of anesthesia, 2008, Volume: 22, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Dexmedetomidine; Female; Humans; Living Donors; Lung Transplantation; Pain; Stomatitis, Herpetic; Treatment Outcome

2008
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
    British journal of pharmacology, 2008, Volume: 155, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Injections, Spinal; Male; Morphine; Pain; Pain Measurement; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Neurokinin-1; Substance P

2008
Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.
    European journal of pain (London, England), 2010, Volume: 14, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Cognition; Cold Temperature; Dexmedetomidine; Female; Genetic Variation; Genotype; Humans; Hypnotics and Sedatives; Male; Memory; Pain; Pain Measurement; Pressure; Psychomotor Performance; Reaction Time; Receptors, Adrenergic, alpha-2; Tandem Mass Spectrometry; Young Adult

2010
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Catheterization; Clonidine; Colon; Data Interpretation, Statistical; Dexmedetomidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Rectum; Yohimbine

2009
Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control.
    Journal of medical and dental sciences, 2009, Volume: 56, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic Antagonists; Animals; Dexmedetomidine; Electromyography; Injections, Spinal; Male; Nerve Fibers, Unmyelinated; Nerve Net; Neural Inhibition; Nociceptors; Pain; Phentolamine; Phenylephrine; Rats; Rats, Wistar

2009
Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:3

    Topics: Animals; Brain; Brain Ischemia; Carbon Dioxide; Cell Survival; Cerebrovascular Circulation; Combined Modality Therapy; Consciousness; Dexmedetomidine; Hypnotics and Sedatives; Hypothermia, Induced; Male; Muscle Tonus; Nervous System Diseases; Neuroprotective Agents; Pain; Postural Balance; Rats; Rats, Sprague-Dawley; Walking

2010
Midazolam enhances the analgesic properties of dexmedetomidine in the rat.
    Veterinary anaesthesia and analgesia, 2010, Volume: 37, Issue:6

    Topics: Analgesia; Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Male; Midazolam; Pain; Rats

2010
Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center.
    Critical pathways in cardiology, 2010, Volume: 9, Issue:4

    Topics: Aged; Aged, 80 and over; Cardiac Surgical Procedures; Clinical Protocols; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Hypotension; Infusions, Intravenous; Intensive Care Units; Male; Middle Aged; Pain; Pain Management; Palliative Care; Postoperative Care; Propofol; Research Design; Respiration, Artificial; Treatment Outcome

2010
Dexmedetomidine and clonidine inhibit the function of Na(v)1.7 independent of α(2)-adrenoceptor in adrenal chromaffin cells.
    Journal of anesthesia, 2011, Volume: 25, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding Sites; Cattle; Cells, Cultured; Chromaffin Cells; Clonidine; Cyclopentanes; Dexmedetomidine; Imidazoles; Lidocaine; Organophosphorus Compounds; Ouabain; Pain; Receptors, Adrenergic, alpha-2; Scorpion Venoms; Sodium; Sodium Channels; Tetrodotoxin; Veratridine; Yohimbine

2011
Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:9

    Topics: Adrenal Gland Neoplasms; Analgesics, Non-Narcotic; Analgesics, Opioid; Antineoplastic Agents; Child, Preschool; Dexmedetomidine; Enterocolitis; Female; Humans; Hydromorphone; Infusions, Intravenous; Neuroblastoma; Pain; Pain Measurement

2011
Ephedrine enhances the antinociceptive effect of dexmedetomidine in mice.
    Neuro endocrinology letters, 2011, Volume: 32, Issue:4

    Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Drug Synergism; Drug Therapy, Combination; Ephedrine; Female; Male; Mice; Motor Activity; Nociceptors; Pain; Pain Threshold

2011
Investigation of modulation of the alpha-2 receptor in tetrahydropalmatine (THP) analgesia in male Sprague-Dawley rats.
    Journal of dietary supplements, 2009, Volume: 6, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Analgesics; Analysis of Variance; Animals; Berberine Alkaloids; Corydalis; Dexmedetomidine; Herb-Drug Interactions; Hot Temperature; Hypnotics and Sedatives; Male; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine

2009
Effects of propofol and dexmedetomidine on motor coordination and analgesia: a comparative analysis.
    International journal of clinical pharmacology and therapeutics, 2012, Volume: 50, Issue:9

    Topics: Analgesics; Animals; Behavior, Animal; Dexmedetomidine; Disease Models, Animal; Hot Temperature; Male; Motor Skills; Pain; Pain Measurement; Pain Threshold; Propofol; Rats; Reaction Time; Time Factors

2012
Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:1

    Topics: Analgesics; Animals; Dexmedetomidine; Mice; Nitric Oxide; Pain; Pain Measurement; Receptors, Adrenergic, alpha-2

2014
Dexmedetomidine in pediatrics: controlled studies needed.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adolescent; Adult; Child; Child, Preschool; Dexmedetomidine; Humans; Infant; Pain; Perioperative Care

2004
Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice.
    British journal of pharmacology, 2005, Volume: 144, Issue:6

    Topics: Acute Disease; Adrenergic alpha-Agonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cannabinoids; Cyclohexanols; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Opioid, mu

2005
The prevention of pain from injection of propofol by dexmedetomidine and comparison with lidocaine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2005, Volume: 52, Issue:5

    Topics: Dexmedetomidine; Humans; Injections, Intravenous; Lidocaine; Pain; Propofol

2005
[Anesthetic management of awake coronary artery bypass grafting using dexmedetomidine--high-dose administration and pharmacokinetic simulation].
    Masui. The Japanese journal of anesthesiology, 2006, Volume: 55, Issue:10

    Topics: Aged; Analgesics, Non-Narcotic; Anesthesia, Epidural; Anesthetics, Local; Coronary Artery Bypass; Dexmedetomidine; Humans; Infusions, Intravenous; Intraoperative Care; Intraoperative Complications; Male; Pain; Wakefulness

2006
Additive interaction of intraperitoneal dexmedetomidine and topical nimesulide, celecoxib, and DFU for antinociception.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Dexmedetomidine; Drug Administration Routes; Drug Synergism; Furans; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2007
Intrathecal infusion therapy with dexmedetomidine-supplemented morphine in cancer pain.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:3

    Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, Opioid; Dexmedetomidine; Drug Therapy, Combination; Humans; Male; Morphine; Neoplasms; Pain; Recurrence

2007
Characterization of spinal alpha-adrenergic modulation of nociceptive transmission and hyperalgesia throughout postnatal development in rats.
    British journal of pharmacology, 2007, Volume: 151, Issue:8

    Topics: Adrenergic alpha-Agonists; Age Factors; Analgesics; Animals; Animals, Newborn; Dexmedetomidine; Dose-Response Relationship, Drug; Electromyography; Heart Rate; Hindlimb; Humans; Infant; Infant, Newborn; Injections, Epidural; Mustard Plant; Nerve Fibers; Pain; Pain Threshold; Plant Oils; Rats; Spinal Cord Injuries

2007
Current state of sedation/analgesia care in dentistry.
    Current opinion in anaesthesiology, 2007, Volume: 20, Issue:4

    Topics: Anesthesia, Dental; Conscious Sedation; Dental Anxiety; Dentistry; Dexmedetomidine; Humans; Hypnotics and Sedatives; Midazolam; Pain; Patient Satisfaction; Propofol

2007
Current world literature.
    Current opinion in anaesthesiology, 2007, Volume: 20, Issue:4

    Topics: Anesthesiology; Dexmedetomidine; Emergency Service, Hospital; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Nerve Block; Pain; Pain Management; Propofol

2007
Neonates have a spinal alpha receptor too, as do adults.
    British journal of pharmacology, 2007, Volume: 151, Issue:8

    Topics: Adrenergic alpha-Agonists; Adult; Age Factors; Analgesics; Animals; Animals, Newborn; Dexmedetomidine; Humans; Infant, Newborn; Injections, Spinal; Pain; Pain Measurement; Pain Threshold; Phenotype; Rats; Receptors, Adrenergic, alpha; Species Specificity

2007
Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 88, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Constriction, Pathologic; Dexmedetomidine; Drug Combinations; Hot Temperature; Hyperalgesia; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Postural Balance; Rats; Rats, Wistar; Reaction Time; Sciatica; Time Factors; Tramadol

2007
Dexmedetomidine relieves pain associated with acute sickle cell crisis.
    Journal of pain and symptom management, 2007, Volume: 34, Issue:4

    Topics: Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Dexmedetomidine; Female; Humans; Male; Pain; Pain Measurement; Treatment Outcome

2007
The efficacy and neurotoxicity of dexmedetomidine administered via the epidural route.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:5

    Topics: Adrenergic alpha-Agonists; Anesthesia, Epidural; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Dexmedetomidine; Heart Rate; Injections, Epidural; Lidocaine; Motor Activity; Myelin Sheath; Pain; Pain Measurement; Rabbits; Random Allocation; Treatment Outcome

2008
Attenuation of ascending nociceptive signals to the rostroventromedial medulla induced by a novel alpha2-adrenoceptor agonist, MPV-2426, following intrathecal application in neuropathic rats.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Dexmedetomidine; Electrophysiology; Hot Temperature; Imidazoles; Indans; Injections, Spinal; Male; Medulla Oblongata; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Signal Transduction

2000
Effects of radolmidine, a novel alpha2 -adrenergic agonist compared with dexmedetomidine in different pain models in the rat.
    Anesthesiology, 2000, Volume: 93, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Area Under Curve; Constriction; Dexmedetomidine; Imidazoles; Indans; Inflammation; Injections, Spinal; Male; Models, Biological; Motor Activity; Pain; Rats; Rats, Sprague-Dawley; Spinal Nerves; Structure-Activity Relationship

2000
Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.
    British journal of pharmacology, 2001, Volume: 132, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dexmedetomidine; Female; Genotype; Guanethidine; Male; Mice; Pain; Peripheral Nerve Injuries; Point Mutation; Receptors, Adrenergic, alpha-2; Sympathectomy, Chemical; Sympatholytics

2001