dexmedetomidine has been researched along with Innate Inflammatory Response in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (7.25) | 29.6817 |
| 2010's | 67 (48.55) | 24.3611 |
| 2020's | 61 (44.20) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, B; Ding, Y; Feng, A; Lv, Y; Shi, J; Wang, M; Zeng, M; Zhang, B; Zhang, Q; Zhao, C; Zheng, X | 1 |
| Chen, X; Chen, Y; Guo, Y; Kan, XX; Kmoníèková, E; Li, Q; Li, YJ; Liu, XC; Wang, YJ; Weng, XG; Yang, L; Yang, Q; Zhang, D; Zhu, XX; Zídek, Z | 1 |
| Gao, J; Hu, W; Huang, T; Li, Y; Wang, Z; Xu, Y; Yang, F; Yu, D; Zong, L | 1 |
| Deng, S; Gong, Y; Jin, P; Lenahan, C; Tan, J; Tian, M; Wang, K; Wang, W; Wang, Y; Wen, H; Zhao, F | 1 |
| Wang, J; Wang, Y | 1 |
| Liu, Y; Zhang, H; Zhang, W | 1 |
| Dong, X; Zhang, L; Zhou, Y | 1 |
| Katoh, T; Kien, TS; Kobayashi, A; Kobayashi, K; Mimuro, S; Nakajima, Y; Sato, T | 1 |
| Chen, H; Jiang, H; Liu, Q; Nie, B | 1 |
| Chen, X; Li, Z; Sun, H; Wang, T; Xia, S; Xu, Z | 1 |
| Suo, L; Wang, M | 1 |
| Li, Y; Shi, Z; Wang, H; Wu, Z | 1 |
| Han, X; Wu, Y; Zhang, J; Zhuang, Y | 1 |
| Huang, Z; Lai, L; Shan, R; Sun, C; Xiao, C; Zhan, L; Zhang, X; Zhao, W | 1 |
| Guo, X; Ji, W; Liang, J; Qingshi, Z; Xue, Y | 1 |
| Ergene, S; Hemsinli, D; Karakisi, SO; Mercantepe, T; Tumkaya, L; Yilmaz, A | 1 |
| Liu, Y; Ma, Y; Wang, P; Wang, W | 1 |
| Deng, K; Hou, M; Zhang, Q | 1 |
| Chen, X; Hu, J; Lai, J; Tang, Z; Zhang, Z | 1 |
| Lehmann, M; Rossaint, J; Zarbock, A | 1 |
| Mu, X; Zhang, Z; Zhou, X | 1 |
| Gao, H; Xiao, S; Yang, D; Zhou, Y | 1 |
| Chen, Z; Deng, Q; Huang, W; Qiu, Y; Shen, J; Wen, S; Zhan, Y | 1 |
| Chen, R; Dai, MS; Dou, XK; Sun, SJ; Sun, Y; Wu, Y | 1 |
| Cox, CS; Haase, CM; Olson, SD; Scott, MC | 1 |
| Gao, L; Jin, B; Shen, J; Zhang, X | 1 |
| Li, L; Li, X; Li, Y; Luo, D; Lyu, Y; Ma, X; Peng, H; Sun, H; Wang, Q; Wang, X; Xu, X; Zhai, Y; Zhang, L; Zhang, Y; Zhuo, L | 1 |
| Geng, D; Gu, C; Hao, Y; Li, X; Qian, X; Shi, Y; Tao, H; Yang, X; Zhang, C; Zhang, L; Zhou, J | 1 |
| Gao, H; Liu, Y; Wang, S; Yin, Y; Yu, J; Zhong, Y | 1 |
| Gong, C; Huang, Y; Liu, X; Tang, Y; Wang, D; Xiong, J; Zhang, Q | 1 |
| Jun, JH; Kim, KS; Kwak, YL; Oh, JE; Shim, JK; Soh, S | 1 |
| Chen, H; Du, L; Gao, W; Li, N; Li, Y; Wu, J; Zhang, Z | 1 |
| Chen, F; Han, X; He, Y; Hou, M; Leng, Y; Shi, Y; Tan, Z; Xu, Y | 1 |
| He, H; Li, P; Liu, P | 1 |
| Fu, Q; Liu, J; Wang, PQ; Xu, ZP; Zhang, H; Zhou, XY | 1 |
| Li, S; Liu, J; Wen, Q; Xie, K; Yu, J; Yu, L; Zhu, Y | 1 |
| Gao, P; Li, F; Wang, X; Zhang, X; Zhang, Z | 1 |
| Song, J; Wang, G; Wei, N; Zhang, J | 1 |
| Beattie, MS; Bresnahan, JC; Chang, YW; Du, Q; Gao, J; Lin, A; Maze, M; Niu, X; Pan, JZ; Sun, W; Sun, Y; Sun, Z; Wang, G; Xiao, Z | 1 |
| Bao, Y; He, G; Liu, C; Ma, L; Ni, H; Shi, D; Zhang, L; Zhu, Y | 1 |
| Ma, D; Wang, G; Wang, K; Wu, C; Wu, M; Xu, J; Zhang, B | 1 |
| Chen, S; Cheng, X; Gu, E; Han, W; Liu, R; Liu, X; Lu, X; Mei, B; Xu, G; Zhang, Y | 1 |
| Feng, J; Lan, J; Peng, W; Zheng, J | 1 |
| Li, Q; Li, R; Lu, P; Lv, Y; Qiu, Z; Wang, K; Wei, H; Wen, J; Zhang, H; Zhang, P; Zhang, S; Zhao, X | 1 |
| Baillie, JK; Edwardson, SA; Flanders, CA; Rocke, AS; Walsh, TS | 1 |
| Duan, W; Liu, Y; Meng, F; Wang, T; Yu, W | 1 |
| Deng, H; Liu, J; Xie, K; Yu, J; Yu, L; Zhai, Y; Zhu, Y | 1 |
| He, Y; Li, E; Li, J; Yang, Z | 1 |
| Cao, X; Che, X; Li, X; Xu, M; Zhang, X | 1 |
| Doğan, G; Karaca, O | 1 |
| Kong, GY; Pan, BB; Pei, WM; Zhang, QQ; Zhao, Y; Zhou, B | 1 |
| Guo, F; Jia, L; Kang, J; Tan, J; Wang, Y; Xu, H | 1 |
| Hou, CQ; Huang, DY; Li, Q; Miao, Y; Shen, HB; Shi, CY | 1 |
| Chen, QH; Hu, Q; Liang, SS; Liu, XM; Liu, Z; Wu, Q; Zhang, HG; Zhang, Q; Zhang, XK | 1 |
| Cao, Y; Wang, M; Wang, S; Wu, Y; Xu, X | 1 |
| Chai, X; Geng, Q; Hu, Y; Shi, S; Tang, C; Wang, H; Wang, J; Wang, S; Wei, Z; Zhang, Z | 1 |
| Bian, J; Bo, L; Guo, P; Jiang, Z; Meng, Q | 1 |
| Bao, N; Tang, B | 1 |
| Chen, CY; Chen, YT; Fu, MX; Jian, YP; Li, SX; Li, XD; Li, Y; Li, YQ; Liu, DH; Ma, J; Mo, ZW; Ning, DS; Ou, JS; Ou, ZJ; Peng, YM; Xu, KQ; Yuan, HX | 1 |
| Cheng, Y; Xue, FS; Yuan, YJ | 1 |
| Lu, Y; Zhu, S | 1 |
| Kawazoe, Y; Miyamoto, K; Morimoto, T; Ohta, Y; Yamamura, H | 1 |
| Akça, B; Ankay Yılbaş, A; Bahador Zırh, E; Büyükakkuş, B; Sarıcaoğlu, F; Üzümcügil, F; Zeybek, D | 1 |
| Wu, Z; Xue, H; Zhang, Y; Zhao, P | 1 |
| Li, J; Mei, B; Zuo, Z | 1 |
| Fan, W; Sun, J; Wang, B; Yang, H; Yang, Y; Zhang, H; Zhou, J | 1 |
| Li, GC; Li, ZB; Qin, J | 1 |
| An, XL; Li, BY; Li, ZH; Liu, GK; Liu, Y; Xiao, SS; Zhang, J | 1 |
| Hu, S; Ju, X; Li, Q; Li, Y; Wang, S; Xu, S | 1 |
| Chen, J; Ding, H; Li, C; Wang, J; Xia, Z; Ye, J | 1 |
| Hao, FG; Huang, GR | 1 |
| He, G; Li, P; Luo, X; Luo, Z; Shen, T; Tan, Y; Wang, Y; Wang, Z; Yang, J; Yang, X; Yu, X | 1 |
| Cao, C; Chen, Y; Cheng, M; Gao, T; Li, Q; Xi, F; Yu, W; Zhao, C | 1 |
| Kim, E; Kim, HC; Kim, JH; Lee, S; Lim, YJ; Park, HP; Park, YH; Ryu, HG | 1 |
| Lin, B; Lu, Y; Zhong, J | 1 |
| Amaya, F; Matsuda, M; Sawa, T; Yamaguchi, Y; Yamakita, S | 1 |
| Gao, T; Jia, S; Liu, Z; Wang, Y; Zhang, R; Zhang, Y | 1 |
| Cheng, XY; Gao, Q; Gu, XY; Hu, J; Li, XH; Li, ZH; Meng, Y; Wang, Y | 1 |
| Feng, X; Hu, J; Lai, IK; Lutrin, D; Maze, M; Uchida, Y; Vacas, S | 1 |
| Guo, YB; Ji, XX; Liang, JX; Xu, JD; Zhang, JX; Zhou, GB | 1 |
| Chang, CC; Hsieh, LP; Hsing, CH; Lin, HC; Lin, MC; Wei, TS; Yeh, CH | 1 |
| Chen, H; Hou, Y; Liu, D; Sun, X; Wang, H; Wang, Y; Wu, J; Yang, X; Yi, W; Yu, J; Yu, X | 1 |
| He, H; He, X; Lin, W; Wang, S; Zhou, Y; Zhuang, J | 1 |
| Chen, C; Chen, X; Han, M; Li, J; Li, Q | 1 |
| Gao, X; Hei, Z; Huang, P; Ji, H; Qiu, R; Sha, W; Wang, F; Yao, W; Yuan, D | 1 |
| Gao, W; Guo, Q; Han, L; Li, F; Liu, H; Ma, Y; Sun, D; Wang, Y; Wang, Z; Wu, Y; Xu, X; Yin, D; Zhang, J; Zhou, S | 1 |
| Cai, JQ; Cao, CC; Guo, RJ; Jia, L; Xu, WX; Xue, X; Yang, HJ; Zhao, W | 1 |
| Dai, J; Fan, X; Hu, J; Liu, J; Yuan, F; Zhang, S | 1 |
| Gao, Y; Lv, S; Masters, J; Sun, Z; Weng, H; Zhao, T | 1 |
| Dong, H; He, Z; Ma, X; Wang, Z; Zhou, W | 1 |
| Alam, A; Hana, Z; Jin, Z; Ma, D; Suen, KC | 1 |
| Doi, M; Katoh, T; Kawashima, S; Kobayashi, A; Kobayashi, K; Makino, H; Mimuro, S; Nakajima, Y; Sato, T | 1 |
| Abad-Gurumeta, A; Calvo-Vecino, JM; Gómez-Ríos, MÁ | 1 |
| Chen, Y; Fan, H; Feng, X; Hu, X; Li, B; Sha, J; Zhang, H | 2 |
| Chen, Q; Chen, S; Jia, C; Jiang, H; Liu, X; Wang, D; Xu, Z; Zhang, D; Zhou, Z | 1 |
| Fan, H; Feng, X; Guan, W; Song, M; Wang, C; Yang, T; Yao, Y; Zhao, Y | 1 |
| Guo, Y; Ji, X; Wang, Q; Wang, Y; Wang, Z; Zhang, J; Zhou, G | 1 |
| Fang, X; Gao, J; Ge, Y; Li, Q; Luo, K; Nie, Y; Wang, C | 1 |
| Chen, LR; Kong, LS; Liu, Y; Wang, RX; Yang, W; Zhu, XX | 1 |
| Chang, RC; Chu, JM; Hu, X; Huang, C; Irwin, MG; Ng, OT; Wong, GT; Zhu, S | 1 |
| Cao, D; Cao, J; Chen, L; Cong, H; Wang, M; Xiang, H; Yang, Y; Ying, T | 1 |
| Chen, N; Chen, X; Qian, J; Wu, C; Xie, J | 1 |
| Wang, M; Wang, N | 1 |
| Lu, J; Wu, C; Zhou, D; Zhou, H; Zhu, Z | 1 |
| Çelik, F; Evliyaoğlu, O; Firat, U; Karaman, H; Kaya, S; Tokgöz, O; Tüfek, A | 1 |
| Liu, HL; Qian, YN | 1 |
| Qian, W; Qian, Y; Sun, L; Wang, J; Xiao, H; Zhang, X; Zhao, J | 1 |
| Higuchi, H; Inoue, M; Maeda, S; Miyawaki, T; Nagatsuka, H; Sukegawa, S | 1 |
| Cai, Y; Lu, Y; Xu, H; Yan, J; Zhang, L | 1 |
| Huang, Y; Jiang, H; Jiang, J; Lu, Y; Yan, J; Zhang, L | 1 |
| Hu, B; Li, J; Li, Z; Xiang, H | 1 |
| He, Z; Shi, Z; Tang, J; Wang, Z; Xie, C | 1 |
| Li, H; Wang, Y; Wang, Z; Zhang, J; Zhou, G | 1 |
| Cheung, CW; Li, S; Qian, L; Wu, Y; Yang, Y; Yao, Y; Yu, C | 1 |
| Gao, C; Li, B; Li, Y; Tian, S; Wang, H; Wu, H; Zhang, A | 1 |
| Chai, X; Huang, X; Kang, F; Li, J; Tang, C; Wang, H; Wang, S; Yin, G | 1 |
| Li, Y; Sun, Y; Wang, X; Xia, Y; Ye, H; Yuan, X | 1 |
| Chen, YJ; Gong, CL; Tan, F; Zhou, SL | 1 |
| Géloën, A; Ghignone, M; Julien, C; Leroy, S; May, CN; Pichot, C; Quintin, L | 1 |
| He, A; Huang, L; Liu, G; Qiu, L; Song, H; Tong, F; Wan, Q; Wang, X; Xia, Y | 1 |
| Li, W; Wang, H; Wang, Q; Xing, X; Zeng, X | 1 |
| Jia, YP; Qiu, YS; Xu, Q | 1 |
| Aoyama, B; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M | 1 |
| Dong, B; Li, J; Ma, J; Wang, H; Wu, X | 1 |
| Chen, C; Qian, Y | 1 |
| Inaba, H; Kobayashi, K; Kurita, A; Taniguchi, T; Yamamoto, K | 1 |
| Brummett, CM; Lydic, R; Norat, MA; Palmisano, JM | 1 |
| Deng, XM; Sun, S; Xu, B; Xu, H; Zhang, WS; Zhang, YQ | 1 |
| Acikgoz, S; Bektas, S; Can, M; Gul, S; Hanci, V | 1 |
| Memis, D; Sut, N; Tasdogan, M; Yuksel, M | 1 |
| Memiş, D; Sezer, A; Süt, N; Usta, U | 1 |
| Chen, C; Peng, M; Wang, CY; Wang, YL | 1 |
| Donovan, DM; Mansikka, H; Pertovaara, A; Raja, SN; Zhou, L | 1 |
| Kanakura, H; Kidani, Y; Takemoto, Y; Taniguchi, T; Yamamoto, K | 1 |
| Benedek, G; Dobos, I; Horvath, G; Kekesi, G; Klimscha, W | 1 |
| Boller, J; Huhtinen, MK; Kästner, SB; Ohlerth, S; Pospischil, A | 1 |
| Kalso, E; Kontinen, VK; Xu, M | 1 |
11 review(s) available for dexmedetomidine and Innate Inflammatory Response
| Article | Year |
|---|---|
[New aspects of perioperative organ protection].
Topics: Dexmedetomidine; HMGB1 Protein; Humans; Inflammation; Ischemic Preconditioning; Pharmaceutical Preparations | 2022 |
The role of dexmedetomidine in immune tissue and inflammatory diseases: a narrative review.
Topics: Anti-Inflammatory Agents; Cytokines; Dexmedetomidine; Humans; Inflammation; Microglia | 2022 |
Dexmedetomidine against intestinal ischemia/reperfusion injury: A systematic review and meta-analysis of preclinical studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Inflammation; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Humans; Immunity; Inflammation; Intraoperative Complications; Postoperative Complications; Preoperative Period; Stress, Physiological | 2019 |
The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Critical Illness; Dexmedetomidine; Disease Models, Animal; Humans; Inflammation | 2019 |
Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine.
Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Catecholamines; Dexmedetomidine; Glutamic Acid; GTP-Binding Proteins; Humans; Hypnotics and Sedatives; Inflammation; Neurotoxins; Oxidative Stress; Signal Transduction | 2020 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibuprofen; Inflammation; Postoperative Complications | 2018 |
Effect of dexmedetomidine on postoperative cognitive dysfunction and inflammation in patients after general anaesthesia: A PRISMA-compliant systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; China; Cognitive Dysfunction; Dexmedetomidine; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Mental Status and Dementia Tests; Odds Ratio; Perioperative Period; Postoperative Complications; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2019 |
Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium; Dexmedetomidine; Humans; Inflammation; Ion Channels; Molecular Targeted Therapy; Oxidative Stress; Reactive Oxygen Species; Regional Blood Flow; Reperfusion Injury; Signal Transduction | 2014 |
Anti-inflammatory Effects of Perioperative Dexmedetomidine Administered as an Adjunct to General Anesthesia: A Meta-analysis.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anti-Inflammatory Agents; Biomarkers; Child; Child, Preschool; Dexmedetomidine; Humans; Infant; Inflammation; Interleukin-10; Interleukin-6; Interleukin-8; Middle Aged; Perioperative Care; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Dexmedetomidine; Humans; Inflammation; Multiple Organ Failure; Norepinephrine; Rats; Sheep; Shock, Septic | 2015 |
18 trial(s) available for dexmedetomidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Effect of dexmedetomidine administration on analgesic, respiration and inflammatory responses in patients undergoing percutaneous endoscopic lumbar discectomy: a prospective observational study.
Topics: Adult; Analgesics; Dexmedetomidine; Diskectomy; Diskectomy, Percutaneous; Endoscopy; Humans; Inflammation; Interleukin-6; Intervertebral Disc Displacement; Lumbar Vertebrae; Pain; Respiration; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury.
Topics: Adrenergic Agonists; Alveolar Epithelial Cells; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Dexmedetomidine; Glutathione; Inflammation; Malondialdehyde; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Effects of Dexmedetomidine Anesthesia on Early Postoperative Cognitive Dysfunction in Elderly Patients.
Topics: Aged; Anesthesia; Cognitive Dysfunction; Dexmedetomidine; Humans; Inflammation; Postoperative Cognitive Complications; Postoperative Complications | 2022 |
Effect of Dexmedetomidine on Inflammatory Response in Aortic Dissection.
Topics: Anesthesia; Aortic Dissection; C-Reactive Protein; Dexmedetomidine; Humans; Inflammation | 2022 |
Effect of dexmedetomidine combined with oxycodone patient-controlled intravenous analgesia on the levels of inflammatory cytokine in patients with rectal cancer.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Cytokines; Dexmedetomidine; Drug Therapy, Combination; Humans; Inflammation; Laparoscopy; Middle Aged; Oxycodone; Pain, Postoperative; Rectal Neoplasms | 2019 |
The Benefit of Dexmedetomidine on Postoperative Cognitive Function Is Unrelated to the Modulation on Peripheral Inflammation: A Single-center, Prospective, Randomized Study.
Topics: Aged; Analgesics, Non-Narcotic; Arthroplasty, Replacement, Knee; Cognition; Dexmedetomidine; Humans; Inflammation; Postoperative Complications; Propofol; Prospective Studies | 2020 |
Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery.
Topics: Administration, Intravenous; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, Opioid; China; Cytokines; Delirium; Dexmedetomidine; Double-Blind Method; Esophageal Neoplasms; Esophagectomy; Female; Health Status; Humans; Inflammation; Inflammation Mediators; Laparoscopy; Male; Middle Aged; Pain, Postoperative; Prospective Studies; Sufentanil; Thoracoscopy; Time Factors; Treatment Outcome | 2020 |
Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial.
Topics: Aged; C-Reactive Protein; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Inflammation; Male; Middle Aged; Procalcitonin; Respiration, Artificial; Sepsis; Treatment Outcome | 2020 |
Effects of intravenous lidocaine, dexmedetomidine, and their combination on IL-1, IL-6 and TNF-α in patients undergoing laparoscopic hysterectomy: a prospective, randomized controlled trial.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Dexmedetomidine; Drug Therapy, Combination; Female; Humans; Hysterectomy; Inflammation; Infusions, Intravenous; Interleukin-1; Interleukin-6; Laparoscopy; Lidocaine; Middle Aged; Pain, Postoperative; Postoperative Nausea and Vomiting; Prospective Studies; Tumor Necrosis Factor-alpha | 2021 |
[Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer].
Topics: Anesthesia; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Interleukin-10; Interleukin-1beta; Lung; Lung Neoplasms; Malondialdehyde; Partial Pressure; Peroxidase; Tumor Necrosis Factor-alpha; Xanthine Oxidase | 2017 |
Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Brain Ischemia; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Case-Control Studies; Cognition Disorders; Dexmedetomidine; Endarterectomy, Carotid; Female; Follow-Up Studies; Gene Expression Regulation; Humans; Inflammation; Male; Prognosis | 2019 |
Effects of Pre-Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study.
Topics: Aged; Anti-Inflammatory Agents; Biomarkers; Cardiopulmonary Bypass; China; Cytokines; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Inflammation; Inflammation Mediators; Male; Malondialdehyde; Middle Aged; Myocardial Reperfusion Injury; Pilot Projects; Prospective Studies; Sevoflurane; Superoxide Dismutase; Time Factors; Treatment Outcome; Troponin I | 2019 |
[Effects of dexmedetomidine on perioperative inflammatory response in patients undergoing valve replacement].
Topics: Aged; Dexmedetomidine; Extracorporeal Circulation; Female; Heart Valve Prosthesis Implantation; Humans; Inflammation; Interleukin-6; Interleukin-8; Intraoperative Period; Male; Middle Aged; Tumor Necrosis Factor-alpha | 2013 |
Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress.
Topics: Adult; Analgesics, Non-Narcotic; Dental Implants; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypnotics and Sedatives; Inflammation; Interleukin-6; Male; Malondialdehyde; Midazolam; Middle Aged; Oxidative Stress; Pain; Postoperative Complications; Severity of Illness Index; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2015 |
Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery.
Topics: Adult; Analgesia; Blood Glucose; Dexmedetomidine; Double-Blind Method; Endoscopy; Epinephrine; Female; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Norepinephrine; Tumor Necrosis Factor-alpha | 2015 |
Clinical efficacy of dexmedetomidine in the diminution of fentanyl dosage in pediatric cardiac surgery.
Topics: Adjuvants, Anesthesia; Airway Extubation; Cardiac Surgical Procedures; Child; Child, Preschool; Dexmedetomidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentanyl; Hemodynamics; Humans; Hypnotics and Sedatives; Infant; Inflammation; Male; Methyl Ethers; Prospective Studies; Sevoflurane; Treatment Outcome | 2017 |
Adding dexmedetomidine to ropivacaine for femoral nerve block inhibits local inflammatory response.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Dexmedetomidine; Drug Therapy, Combination; Female; Femoral Nerve; Humans; Inflammation; Male; Nerve Block; Postoperative Complications; Prospective Studies; Ropivacaine | 2017 |
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.
Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Humans; Hypnotics and Sedatives; Inflammation; Infusions, Intravenous; Interleukin-1; Interleukin-6; Male; Middle Aged; Pilot Projects; Pressure; Propofol; Prospective Studies; Respiration, Artificial; Sepsis; Severity of Illness Index; Tumor Necrosis Factor-alpha; Young Adult | 2009 |
109 other study(ies) available for dexmedetomidine and Innate Inflammatory Response
| Article | Year |
|---|---|
Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways.
Topics: Acute Lung Injury; Animals; Apoptosis; Flavones; Inflammation; Lipopolysaccharides; Mice; NF-kappa B; Oxidative Stress; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo.
Topics: Animals; Artemisia annua; Dermatitis; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Edema; Flavones; Flavonoids; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Male; Mice; Mice, Inbred ICR | 2015 |
Dexmedetomidine attenuates haemorrhage-induced thalamic pain by inhibiting the TLR4/NF-κB/ERK1/2 pathway in mice.
Topics: Analgesics, Non-Narcotic; Animals; Dexmedetomidine; Disease Models, Animal; Hemorrhage; Inflammation; Male; MAP Kinase Signaling System; Mice; Neuralgia; NF-kappa B; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1/Th2/Th17 polarization in an experimental sepsis model of mice.
Topics: Animals; Blood-Brain Barrier; Cecum; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Hippocampus; Inflammation; Male; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Sepsis; Th17 Cells | 2021 |
Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis
Topics: Animals; Apoptosis; Base Sequence; Cell Line; Cell Proliferation; Dexmedetomidine; Down-Regulation; Hippocampus; Hypoxia; Inflammation; Mice; MicroRNAs; Neurons; Neuroprotective Agents; Oxygen; RNA, Circular; Signal Transduction; TNF Receptor-Associated Factor 3 | 2021 |
Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery.
Topics: Analgesics; Anesthesia; Cognitive Dysfunction; Dexmedetomidine; Female; Heart Rate; Humans; Inflammation; Male; Middle Aged; Oxygen Saturation; Pain Measurement; Ropivacaine | 2021 |
Dexmedetomidine Can Reduce the Level of Oxidative Stress and Serum miR-10a in Patients with Lung Cancer after Surgery.
Topics: Dexmedetomidine; Humans; Inflammation; Lung Neoplasms; MicroRNAs; Oxidative Stress; Treatment Outcome | 2023 |
Dexmedetomidine suppresses serum syndecan-1 elevation and improves survival in a rat hemorrhagic shock model.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Inflammation; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Syndecan-1; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine alleviates hyperalgesia in arthritis rats through inhibition of the p38MAPK signaling pathway.
Topics: Animals; Anisomycin; Arthritis; Dexmedetomidine; Freund's Adjuvant; Hyperalgesia; Inflammation; MAP Kinase Signaling System; Rats; Rats, Sprague-Dawley | 2022 |
Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells.
Topics: Apoptosis; Cell Proliferation; Dexmedetomidine; Humans; Hypoxia; Inflammation; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Proto-Oncogene Proteins c-akt | 2022 |
Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-κB axis.
Topics: Animals; Dexmedetomidine; Glucose; Inflammation; MicroRNAs; NF-kappa B; Oxygen; Rats; Reperfusion; Toll-Like Receptor 4 | 2022 |
Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis.
Topics: Aged; Animals; Dexmedetomidine; Humans; Inflammation; Lipopolysaccharides; Microglia; MicroRNAs; Postoperative Cognitive Complications; Rats; Vesicle-Associated Membrane Protein 1 | 2022 |
Dexmedetomidine reduces dextran sulfate sodium (DSS)-induced NCM460 cell inflammation and barrier damage by inhibiting RhoA/ROCK signaling pathway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Dexmedetomidine; Dextran Sulfate; Humans; Inflammation; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction | 2022 |
Effects of administration of α
Topics: Adrenergic Agonists; Analgesics; Animals; Dexmedetomidine; Freund's Adjuvant; Hyperalgesia; Inflammation; Low Back Pain; Muscles; Rats; Receptors, Adrenergic | 2022 |
Study on the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction and Inflammation in Aged Rats.
Topics: Animals; Cytokines; Dexmedetomidine; Inflammation; Interleukin-6; Male; Postoperative Cognitive Complications; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregulation of miR-140-3p and Partial Suppression of PD-L1 Involving Inactivating JNK-Bnip3 Pathway.
Topics: B7-H1 Antigen; Dexmedetomidine; Humans; Inflammation; Lipopolysaccharides; Membrane Proteins; MicroRNAs; Proto-Oncogene Proteins; Up-Regulation | 2022 |
Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm.
Topics: Animals; Cytokines; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Hydrogen Peroxide; Inflammation; Intracranial Aneurysm; Muscle, Smooth, Vascular; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Adrenergic, alpha-2; Sincalide | 2022 |
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Topics: Animals; Antioxidants; Asthma; Dexmedetomidine; Inflammation; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2023 |
DEXMEDETOMIDINE PREVENTS PDIA3 DECREASE BY ACTIVATING α2-ADRENERGIC RECEPTOR TO ALLEVIATE INTESTINAL I/R IN MICE.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Dexmedetomidine; Inflammation; Mice; Mice, Inbred C57BL; Protein Disulfide-Isomerases; Receptors, Adrenergic, alpha-2; Yohimbine | 2022 |
Dexmedetomidine Alters the Inflammatory Profile of Rat Microglia In Vitro.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brain Injuries, Traumatic; Cytokines; Dexmedetomidine; Inflammation; Interleukin-10; Lipopolysaccharides; Microglia; Poly I; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2023 |
Dexmedetomidine alleviates host ADHD-like behaviors by reshaping the gut microbiota and reducing gut-brain inflammation.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Dexmedetomidine; Encephalitis; Gastrointestinal Microbiome; Inflammation; Rats; Rats, Inbred SHR | 2023 |
Dexmedetomidine alleviates osteoarthritis inflammation and pain through the CB
Topics: Animals; Dexmedetomidine; Inflammation; Osteoarthritis; Pain; Rats; Synovial Membrane | 2023 |
Dexmedetomidine suppresses hippocampal astrocyte pyroptosis in cerebral hypoxic-ischemic neonatal rats by upregulating microRNA-148a-3p to inactivate the STAT/JMJD3 axis.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Caspase 1; Dexmedetomidine; Glucose; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Inflammation; Ischemia; MicroRNAs; Pyroptosis; Rats | 2023 |
Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis.
Topics: Animals; Cytokines; Dexmedetomidine; Inflammation; Lipopolysaccharides; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Sepsis; Tumor Necrosis Factor-alpha | 2023 |
Effects of dexmedetomidine on A549 non-small cell lung cancer growth in a clinically relevant surgical xenograft model.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Dexmedetomidine; Heterografts; Humans; Inflammasomes; Inflammation; Interleukin-10; Interleukin-18; Lung Neoplasms; Mice; Mice, Nude; NLR Family, Pyrin Domain-Containing 3 Protein | 2023 |
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF-κB.
Topics: Animals; Dexmedetomidine; Infarction; Inflammation; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2023 |
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Dexmedetomidine; Inflammation; Ischemia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion Injury; Signal Transduction; Sirtuin 3 | 2023 |
Dexmedetomidine inhibits the lipopolysaccharide-stimulated inflammatory response in microglia through the pathway involving TLR4 and NF-κB.
Topics: Animals; Blotting, Western; Cell Line; Cell Survival; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats.
Topics: Animals; Autophagy; Brain Injuries; Dexmedetomidine; Infarction, Middle Cerebral Artery; Inflammation; JNK Mitogen-Activated Protein Kinases; Learning Disabilities; MAP Kinase Signaling System; Memory Disorders; Rats; Reperfusion Injury | 2019 |
Dexmedetomidine Attenuates Neuroinflammatory-Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway.
Topics: Animals; Apoptosis; Brain; Brain Injuries, Traumatic; Dexmedetomidine; Inflammation; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Signal Transduction | 2019 |
Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cells, Cultured; Dexmedetomidine; Disease Models, Animal; Female; Inflammation; Microglia; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord; Spinal Cord Injuries | 2019 |
Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Cytokines; Dexmedetomidine; Inflammation; Lipopolysaccharides; Mice; Microglia; MicroRNAs; NF-kappa B; Up-Regulation | 2019 |
Nrf2 mediates the antinociceptive activity of dexmedetomidine in an acute inflammatory visceral pain rat model by activating the NF-κB sensor.
Topics: Acute Disease; Analgesics; Animals; Dexmedetomidine; Disease Models, Animal; Inflammation; Male; NF-E2-Related Factor 2; NF-kappa B; Nociception; Rats; Rats, Sprague-Dawley; Visceral Pain | 2020 |
Dexmedetomidine Inhibits Neuroinflammation by Altering Microglial M1/M2 Polarization Through MAPK/ERK Pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Cell Polarity; Dexmedetomidine; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Microglia; Nitric Oxide | 2020 |
Dexmedetomidine attenuates LPS-mediated BV2 microglia cells inflammation via inhibition of glycolysis.
Topics: Animals; Cell Line; Cytokines; Dexmedetomidine; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lipopolysaccharides; Mice; Microglia; Sirtuin 1; Up-Regulation | 2020 |
Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway.
Topics: Animals; Brain Ischemia; Dexmedetomidine; HMGB1 Protein; Hydrogen Peroxide; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells.
Topics: Adenylate Kinase; Animals; Apoptosis; Cell Cycle Proteins; Cell Line; Cell Survival; Dexmedetomidine; Doxorubicin; Glycogen Synthase Kinase 3 beta; Inflammation; Myocytes, Cardiac; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Reactive Oxygen Species; Signal Transduction; Taurine | 2020 |
Dexmedetomidine reduces myocardial ischemia-reperfusion injury in rats through PI3K/AKT/GSK-3β signaling pathway.
Topics: Animals; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Hypnotics and Sedatives; Inflammation; Myocardial Reperfusion Injury; Oncogene Protein v-akt; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction | 2020 |
The effects of dexmedetomidine in increased intestinal permeability after traumatic brain injury: An experimental study.
Topics: Animals; Brain Injuries, Traumatic; Cytokines; Dexmedetomidine; Disease Models, Animal; Inflammation; Intestinal Absorption; Intestinal Mucosa; Rats | 2020 |
Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway.
Topics: Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dexmedetomidine; Down-Regulation; Glucose; Heme Oxygenase-1; Hepatocytes; Humans; Inflammation; Liver; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Reperfusion Injury; Signal Transduction; Up-Regulation | 2019 |
Dexmedetomidine Pretreatment Improves Lipopolysaccharide-induced Iron Homeostasis Disorder in Aged Mice.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Hippocampus; Homeostasis; Inflammation; Iron; Lipopolysaccharides; Male; Maze Learning; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species | 2020 |
Dexmedetomidine attenuates inflammation and pancreatic injury in a rat model of experimental severe acute pancreatitis via cholinergic anti-inflammatory pathway.
Topics: Acute Disease; Animals; Dexmedetomidine; Inflammation; Neuroimmunomodulation; Pancreatitis; Rats; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine protects intestinal ischemia-reperfusion injury via inhibiting p38 MAPK cascades.
Topics: Animals; Apoptosis; Caco-2 Cells; Dexmedetomidine; Glucose; Humans; Inflammation; Intestines; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Oxygen; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats, Wistar; Reperfusion Injury | 2020 |
Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.
Topics: Aging; Animals; Benzylisoquinolines; Brain; Dexmedetomidine; Inflammasomes; Inflammation; Male; Mitochondria; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species | 2019 |
Dexmedetomidine inhibits LPS-induced proinflammatory responses via suppressing HIF1α-dependent glycolysis in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cell Culture Techniques; Dexmedetomidine; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL | 2020 |
Circulating extracellular vesicles from patients with valvular heart disease induce neutrophil chemotaxis via FOXO3a and the inhibiting role of dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Animals; Case-Control Studies; Chemokine CCL5; Chemotaxis, Leukocyte; Dexmedetomidine; Extracellular Vesicles; Female; Forkhead Box Protein O3; Heart Valve Diseases; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Kidney; Male; Mice; Middle Aged; Neutrophils; Phosphorylation; Platelet Factor 4; Proto-Oncogene Proteins c-akt; Renal Insufficiency; Vasodilation | 2020 |
Assessing Benefit of Dexmedetomidine on Postoperative Neurocognitive Disorders: Important Issues That Should Be Acknowledged.
Topics: Cognition; Dexmedetomidine; Humans; Inflammation; Neurocognitive Disorders; Prospective Studies | 2020 |
Dexmedetomidine Suppressed the Biological Behavior of HK-2 Cells Treated with LPS by Down-Regulating ALKBH5.
Topics: AlkB Homolog 5, RNA Demethylase; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dexmedetomidine; Down-Regulation; Epigenesis, Genetic; Humans; Immunoprecipitation; In Vitro Techniques; Inflammation; Lipopolysaccharides; NF-kappa B; RNA, Long Noncoding; Sepsis; Signal Transduction | 2020 |
How does intraarticular dexmedetomidine injection effect articular cartilage and synovium? An animal study.
Topics: Analgesics, Non-Narcotic; Animals; Cartilage, Articular; Dexmedetomidine; Disease Models, Animal; Edema; Fibrosis; Inflammation; Injections, Intra-Articular; Male; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Synovial Membrane | 2020 |
Dexmedetomidine alleviates neurobehavioral impairments and myelination deficits following lipopolysaccharide exposure in early postnatal rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Dexmedetomidine; Disease Models, Animal; Female; Gliosis; Inflammation; Lipopolysaccharides; Male; Neuroprotective Agents; Pregnancy; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor | 2020 |
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor.
Topics: Animals; Brain Diseases; Dexmedetomidine; Inflammation; Male; Mice; Receptors, Adrenergic; Sepsis | 2021 |
Application of dexmedetomidine combined with ropivacaine in axillary brachial plexus block in children and its effect on inflammatory factors.
Topics: Anesthetics, Local; Arterial Pressure; Brachial Plexus Block; Child; Dexmedetomidine; Female; Heart Rate; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Pain Measurement; Ropivacaine; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy.
Topics: Animals; Autophagy; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Inflammation; Lung Injury; Male; Rats; Rats, Sprague-Dawley; Shock, Septic | 2021 |
Dexmedetomidine promotes the recovery of renal function and reduces the inflammatory level in renal ischemia-reperfusion injury rats through PI3K/Akt/HIF-1α signaling pathway.
Topics: Animals; Dexmedetomidine; Hypnotics and Sedatives; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Injections, Intraperitoneal; Kidney; Kidney Function Tests; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy.
Topics: Adrenergic alpha-2 Receptor Agonists; Autophagy; Cell Line; Cognitive Dysfunction; Dexmedetomidine; Ferritins; Hippocampus; Humans; Inflammation; Methotrexate; Neuroprotective Agents; Nuclear Receptor Coactivators | 2021 |
Dexmedetomidine Inhibits Inflammation to Alleviate Early Neuronal Injury via TLR4/NF-κB Pathway in Rats with Traumatic Brain Injury.
Topics: Animals; Apoptosis; Autophagy; Brain Injuries, Traumatic; Cytokines; Dexmedetomidine; Disease Models, Animal; Inflammation; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke.
Topics: Animals; Dexmedetomidine; Heat Stroke; Inflammation; Male; Membrane Glycoproteins; Mice; Mice, Inbred ICR; Microglia; Nitric Oxide Synthase Type II; Phenotype; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Immunologic; Signal Transduction | 2021 |
Dexmedetomidine ameliorates muscle wasting and attenuates the alteration of hypothalamic neuropeptides and inflammation in endotoxemic rats.
Topics: Agouti-Related Protein; Animals; Dexmedetomidine; Endotoxemia; Hypothalamus; Inflammation; Interleukin-1; Male; Methylhistidines; Muscle, Skeletal; Muscular Atrophy; Nerve Tissue Proteins; Neuropeptide Y; Neuropeptides; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2017 |
Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Encephalitis; Hippocampus; Inflammation; Inflammation Mediators; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2017 |
The Therapeutic Effect of Dexmedetomidine on Rat Diabetic Neuropathy Pain and the Mechanism.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glutamic Acid; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Microglia; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha; Yohimbine | 2017 |
Dexmedetomidine prolongs levobupivacaine analgesia via inhibition of inflammation and p38 MAPK phosphorylation in rat dorsal root ganglion.
Topics: Animals; Bupivacaine; Dexmedetomidine; Ganglia, Spinal; Inflammation; Levobupivacaine; Male; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pain; Pain Management; Phosphorylation; Rats, Sprague-Dawley | 2017 |
Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Movement; Cells, Cultured; Cytokines; Dexmedetomidine; Epithelial Cells; Inflammation; Interleukin-17; Lung; Mice; Mice, Inbred Strains; Neutrophils; NF-kappa B | 2018 |
[Effect of dexmedetomidine postconditioning on myocardial ischemia-reperfusion injury and inflammatory response in diabetic rats].
Topics: Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Inflammation; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley | 2017 |
Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice.
Topics: Animals; Blood-Brain Barrier; Cognitive Dysfunction; Dexmedetomidine; HMGB1 Protein; Imidazoline Receptors; Inflammation; Male; Mice; Mice, Inbred C57BL; Netrin-1; Receptors, Nicotinic; Vagus Nerve | 2018 |
Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia.
Topics: Anhedonia; Animals; Apoptosis; Brain; Dexmedetomidine; Illness Behavior; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Microglia; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dexmedetomidine; Humans; Inflammation; Lung; Male; NF-kappa B; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Signal Transduction; Toll-Like Receptor 4; Ventilator-Induced Lung Injury; Yohimbine | 2018 |
Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Inflammation; Male; Microglia; Programmed Cell Death 1 Receptor; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Up-Regulation | 2018 |
Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cellular Senescence; Dexmedetomidine; Fibrosis; Imidazoles; Inflammation; Isoindoles; Kidney; Male; Mice; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction; Sirolimus | 2018 |
Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cecal Diseases; Cecum; Cytokines; Dexmedetomidine; Imidazoles; Inflammation; Kidney; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sepsis; Toll-Like Receptor 4 | 2018 |
Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexmedetomidine; Inflammasomes; Inflammation; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Subarachnoid Hemorrhage; Toll-Like Receptor 4 | 2018 |
Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system.
Topics: Acute Lung Injury; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Immune System; Inflammation; Ki-67 Antigen; NF-kappa B; Protective Agents; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Taurine | 2018 |
Dexmedetomidine Preconditioning Ameliorates Inflammation and Blood-Spinal Cord Barrier Damage After Spinal Cord Ischemia-Reperfusion Injury by Down-Regulation High Mobility Group Box 1-Toll-Like Receptor 4-Nuclear Factor κB Signaling Pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Down-Regulation; HMGB1 Protein; Inflammation; Male; NF-kappa B; Rabbits; Reperfusion Injury; Signal Transduction; Spinal Cord Ischemia; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine attenuates spinal cord ischemia-reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits.
Topics: Animals; Apoptosis; Blood Pressure; Caspase 3; Dexmedetomidine; Female; Heart Rate; Inflammation; Male; Microglia; Models, Biological; Motor Activity; NF-kappa B; Rabbits; Reperfusion Injury; Signal Transduction; Spinal Cord Ischemia; Toll-Like Receptor 4 | 2018 |
Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK.
Topics: Adenylate Kinase; Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; Enzyme Activation; Infarction, Middle Cerebral Artery; Inflammation; Male; Motor Activity; Neurons; Phosphorylation; Rats, Sprague-Dawley; Reperfusion Injury | 2018 |
Dexmedetomidine preserves the endothelial glycocalyx and improves survival in a rat heatstroke model.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Glycocalyx; Heat Stroke; Inflammation; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2018 |
Intravenous dexmedetomidine: can it modulate the effects of inflammation, or is it only an antinociceptive agent?
Topics: Dexmedetomidine; Humans; Inflammation; Inflammation Mediators; Reperfusion Injury; Tourniquets | 2019 |
Dexmedetomidine improves acute stress-induced liver injury in rats by regulating MKP-1, inhibiting NF-κB pathway and cell apoptosis.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Behavior, Animal; Dexmedetomidine; Dual Specificity Phosphatase 1; Humans; Inflammation; JNK Mitogen-Activated Protein Kinases; Liver; Lung; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA | 2019 |
Dexmedetomidine Attenuates Renal and Myocardial Ischemia/Reperfusion Injury in a Dose-Dependent Manner by Inhibiting Inflammatory Response.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Inflammation; Inflammation Mediators; Kidney Diseases; Male; Myocardial Ischemia; Rats; Rats, Wistar; Reperfusion Injury | 2019 |
Dexmedetomidine ameliorates lipopolysaccharide-induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK-3β/Nrf2 signaling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Inflammation; Kidney Tubules; Lipopolysaccharides; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Dexmedetomidine protects against high mobility group box 1-induced cellular injury by inhibiting pyroptosis.
Topics: Animals; Cytokines; Dexmedetomidine; HMGB1 Protein; Inflammation; Interleukin-18; Interleukin-1beta; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pyroptosis; Tumor Necrosis Factor-alpha | 2019 |
Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice.
Topics: Animals; Antioxidants; Brain; Cognition Disorders; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Maze Learning; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Propofol; Rotarod Performance Test; Tumor Necrosis Factor-alpha | 2019 |
Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia/reperfusion injury: An in vivo and in vitro study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Dexmedetomidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Hyperglycemia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction | 2019 |
Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2019 |
Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation.
Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Inflammation; Interleukin-1beta; Male; Postoperative Cognitive Complications; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway.
Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Chromones; Cytokines; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Hypnotics and Sedatives; Inflammation; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Sevoflurane; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
The protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Local; Animals; Antioxidants; Aryldialkylphosphatase; Bupivacaine; Dexmedetomidine; Edema; Female; Galectin 3; Inflammation; Mast Cells; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nerve Block; Oxidative Stress; Rats; Rats, Wistar; Sciatic Nerve | 2013 |
Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Astrocytes; Cell Survival; Cells, Cultured; Dexmedetomidine; Gene Expression; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Locally injected dexmedetomidine inhibits carrageenin-induced inflammatory responses in the injected region.
Topics: Adrenergic alpha-2 Receptor Antagonists; Anesthetics; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Dexmedetomidine; Edema; Immunohistochemistry; Inflammation; Leukocytes; Male; Mice; Receptors, Adrenergic, alpha-2; Time Factors; Tumor Necrosis Factor-alpha; Yohimbine | 2014 |
Perineural dexmedetomidine attenuates inflammation in rat sciatic nerve via the NF-κB pathway.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Nucleus; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Gene Expression; Inflammation; Interleukin-6; NF-kappa B; Protein Binding; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sciatic Nerve; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Cytokines; Dexmedetomidine; Endotoxemia; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Signal Transduction | 2014 |
The effect of dexmedetomidine post-treatment on the inflammatory response of astrocyte induced by lipopolysaccharide.
Topics: Animals; Astrocytes; Dexmedetomidine; Gene Expression Regulation, Enzymologic; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mice; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; RNA, Messenger; Survival Analysis; Tumor Necrosis Factor-alpha | 2015 |
The effect of dexmedetomidine on inflammatory response of septic rats.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-6; Ligation; Male; MAP Kinase Signaling System; Myeloid Differentiation Factor 88; NF-kappa B; Random Allocation; Rats, Sprague-Dawley; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Yohimbine | 2015 |
[Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury].
Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Inflammation; Interleukin-1beta; Kidney; Lipopolysaccharides; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sepsis; Superoxide Dismutase | 2015 |
Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia/reperfusion injury in rats.
Topics: Actins; Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Blood Urea Nitrogen; Blotting, Western; Creatinine; Dexmedetomidine; HMGB1 Protein; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Kidney; Male; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats.
Topics: Animals; Brain Ischemia; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Hemodynamics; Inflammation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
[The protective effect of alpha-2 adrenergic agonist on cranial nerve in rats with brain injury].
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Brain Injuries; Cranial Nerves; Dexmedetomidine; Inflammation; Interleukin-6; Male; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; Tumor Necrosis Factor-alpha | 2016 |
Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats.
Topics: Aging; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Imidazoles; Inflammation; Isoindoles; Isoquinolines; Lipopolysaccharides; Male; Memory Disorders; Neuroprotective Agents; Piperazines; Rats; Signal Transduction | 2017 |
Protective role of dexmedetomidine in unmethylated CpG-induced inflammation responses in BV2 microglia cells.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; CpG Islands; Dexmedetomidine; DNA, Bacterial; Inflammation; Male; Mice, Inbred C57BL; Microglia; Tumor Necrosis Factor-alpha | 2016 |
Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Gas Analysis; Blood Pressure; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Inflammation; Interleukin-6; Male; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Survival Rate; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2008 |
Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Animals; Bupivacaine; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Inflammation; Male; Models, Animal; Motor Activity; Nerve Block; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensation; Sodium Chloride; Time Factors | 2008 |
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Analysis of Variance; Animals; Ankle Joint; Arthritis, Experimental; Cyclohexanecarboxylic Acids; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Inflammation; Injections, Intra-Articular; Male; Motor Activity; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Edema; Inflammation; Interleukin-6; Male; Methylprednisolone; Neutrophil Infiltration; Rats; Rats, Wistar; Spinal Cord Injuries; Tumor Necrosis Factor-alpha | 2009 |
The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study.
Topics: Adrenergic alpha-Agonists; Animals; Dexmedetomidine; Endotoxemia; Endotoxins; Escherichia coli; Female; Inflammation; Lipopolysaccharides; Liver; Rats; Rats, Wistar; Sepsis | 2010 |
Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cell Survival; Cells, Cultured; Dexmedetomidine; Dinoprostone; Dose-Response Relationship, Drug; Inflammation; Interleukin-1beta; Lipopolysaccharides; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2013 |
The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carrageenan; Decerebrate State; Dexmedetomidine; Foot; Hindlimb; Hot Temperature; Hyperalgesia; Imidazoles; Inflammation; Mice; Mice, Knockout; Nociceptors; Physical Stimulation; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Reference Values | 2002 |
Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats.
Topics: Animals; Dexmedetomidine; Endotoxins; Hemodynamics; Hypnotics and Sedatives; Inflammation; Interleukin-6; Lung; Male; Neutrophils; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Tumor Necrosis Factor-alpha | 2004 |
Long-term changes in the antinociceptive potency of morphine or dexmedetomidine after a single treatment.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Carrageenan; Dexmedetomidine; Drug Tolerance; Foot; Hot Temperature; Hyperalgesia; Inflammation; Male; Morphine; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Time Factors | 2005 |
Dexmedetomidine-induced pulmonary alterations in sheep.
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Blood Pressure; Dexmedetomidine; Dinoprostone; Inflammation; Lung; Nitric Oxide; Oxygen; Polymerase Chain Reaction; Pulmonary Edema; Sheep; Sheep Diseases; Vasoconstriction | 2007 |
Effects of radolmidine, a novel alpha2 -adrenergic agonist compared with dexmedetomidine in different pain models in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Area Under Curve; Constriction; Dexmedetomidine; Imidazoles; Indans; Inflammation; Injections, Spinal; Male; Models, Biological; Motor Activity; Pain; Rats; Rats, Sprague-Dawley; Spinal Nerves; Structure-Activity Relationship | 2000 |