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dexmedetomidine and Injury, Myocardial Reperfusion

dexmedetomidine has been researched along with Injury, Myocardial Reperfusion in 76 studies

Research

Studies (76)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (1.32)	29.6817
2010's	23 (30.26)	24.3611
2020's	52 (68.42)	2.80

Authors

Authors	Studies
Cao, S; Chen, H; Chen, Y; Xu, X; Yang, Z; Yin, C	1
Chu, Y; Feng, P; Liu, H; Teng, J; Wang, F; Wang, H	1
Liu, Y; Qu, X; Wang, J; Wang, X; Zhang, J	1
Cai, S; Cheng, Y; Fang, J; Liu, Y; Yuan, J	1
Leng, YF; Liu, ZZ; Peng, CM; Zhang, GR	1
Dong, H; Yang, FY; Zhang, L; Zheng, Y	1
Chen, D; Ding, Y; Fu, L; Li, S; Li, X; Sun, H; Yang, P; Yu, P; Yu, S; Yuan, F; Zhang, J	1
Chen, X; Li, Z; Sun, H; Wang, T; Xia, S; Xu, Z	1
Chen, S; Huan, Y; Tailaiti, T; Wang, J; Wu, J; Yang, L; Zou, T	1
Deng, X; Luo, W; Tu, S; Wang, X; Ye, F; Zeng, L; Zhang, Z	1
Li, HX; Wang, TH; Wu, LX; Xue, FS; Yan, T; Zhang, GH	1
Jiang, L; Qian, J; Qian, X; Wang, L; Wang, Q; Wang, Z; Yang, Y; Yao, M; Zhao, Y	1
Chen, S; Huang, Y; Li, A; Tailaiti, T; Wang, J; Wu, J; Zou, T	1
Lu, SJ; Qi, QL; Wang, HY; Zhang, YJ	1
Chen, PS; Chen, YG; Cheng, Y; Hao, PP; Hu, B; Jiang, TY; Li, XT; Liu, WC; Tian, T; Xue, FS	1
Chen, S; Huang, Y; Jiang, J; Li, A; Tailaiti, T; Wang, J; Wu, J; Zou, T	1
Chen, K; Guo, P; Han, M; Liu, X; Qing, J; Yang, F; Yi, H	1
Gao, N; Ma, X; Song, T; Tian, J; Xu, J	1
Huang, Z; Li, S; Li, Y; Liang, G	1
Chen, ZR; Hong, Y; Huang, WQ; Wen, SH; Zhan, YQ	1
Bai, X; Dai, N; Liu, J; Qian, J; Qian, X; Wang, L; Wang, Q; Wang, Z; Xie, Y; Yang, W; Yang, Y; Zeng, W; Zhao, Y	1
Chen, H; Du, L; Gao, W; Li, N; Li, Y; Wu, J; Zhang, Z	1
Chen, S; Cheng, H; Wang, J; Wu, J; Yang, X	1
He, H; Li, P; Liu, P	1
Chen, H; Chen, Y; Xu, W; Yang, Z; Zhou, T	1
Behmenburg, F; Bunte, S; Heinen, A; Hollmann, MW; Huhn, R; Majewski, N; Mathes, A; Raupach, A; Stroethoff, M	1
Chen, WR; Ji, FH; Liu, H; Liu, HY; Meng, XW; Peng, K; Xia, F; Xia, ZY; Zhang, J	1
Patel, HH; Roth, DM; Satomi, S	1
Li, J; Li, K; Li, L; Zhao, Y; Zhou, N	1
Cao, X; Che, X; Li, X; Xu, M; Zhang, X	1
Liu, L; Qian, J; Song, N; Wang, Z; Xiong, W; Yang, Y; Zhou, R	1
Liu, H; Peng, Y; Qian, J; Ren, C; Wang, C; Xia, Z; Yin, W; Yuan, W; Zhang, Z	1
Li, Y; Ma, W; Ren, X; Wang, Y; Yang, K; Zhang, X; Zhong, M; Zhuang, Y	1
Chang, JH; Jin, MM; Liu, JT	1
Chai, X; Gao, J; Geng, Q; Hu, Y; Jiang, J; Liang, X; Shi, S; Tang, C; Wang, J	1
Gao, H; Hu, BL; Li, YP; Yin, YQ; Zhong, Y	1
Brandenburger, T; Bunte, S; Feige, K; Heinen, A; Hollmann, MW; Huhn, R; Karakurt, E; Raupach, A; Stroethoff, M; Torregroza, C	1
Ling, X; Yan, W; Zhang, C; Zhou, H; Zhu, Z	1
He, L; Qian, J; Song, N; Wang, Z; Xiong, W; Yang, Y; Zhou, R	1
Davis, JRJ; Wu, ZL; Zhu, Y	1
An, XL; Li, BY; Li, ZH; Liu, GK; Liu, Y; Xiao, SS; Zhang, J	1
Cai, J; Chen, S; Ju, Y; Lu, J; Xiao, F; Zhou, B	1
Shao, Q; Wu, P; Xia, J; Ying, J	1
Cai, L; Deng, Y; Huang, J; Li, L; Lv, H; Wang, F; Wang, H	1
Chang, Y; Xing, L; Zhang, W; Zhou, W	1
Hou, X; Kong, M; Ni, H; Shao, Z; Shen, Q	1
Ji, F; Li, X; Zhang, Y; Zhao, Q	1
Huang, Y; Juan, Z; Li, Y; Meng, S; Sun, X; Wang, R; Xie, K; Xu, K; Zhang, R; Zhou, J	1
Suades, R	1
Hou, LJ; Xie, MY	1
Sun, Z; Wang, H; Xia, Y	1
Chen, J; Liu, Y; Wang, Y; Wu, C; Xiong, B	1
Liang, R; Qian, J; Qu, Y; Song, N; Wang, Z; Xiong, W; Yang, Y; Zhou, R	1
Jiang, C; Jiang, J; Qiu, L; Sun, Y	1
Hirata, N; Kawaguchi, R; Tokinaga, Y; Yamakage, M; Yoshikawa, Y	1
Dong, J; Guo, X; Li, L; Yang, S	1
Cheng, XY; Gao, Q; Gu, XY; Hu, J; Li, XH; Li, ZH; Meng, Y; Wang, Y	1
Dong, Z; Li, C; Liu, H; Liu, Y; Ren, J	1
Chen, H; Deng, L; Wang, G; Wei, N; Zhang, Z	1
Cheng, X; Gao, Q; Hu, J; Li, X; Li, Z; Wang, Y; Ye, H	1
Cao, J; Chen, J; Jiang, Z; Liu, Y; Sun, X; Wang, X; Zhou, X	1
Hirata, N; Sawashita, Y; Terada, H; Yamakage, M; Yoshikawa, Y	1
Du, J; Leng, JY; Liu, J; Xu, Z; Yang, D; Zhen, J; Zheng, EL	1
Chen, C; Ji, F; Liu, H; Meng, X; Peng, K; Xia, F; Zhang, J; Zhao, H	1
Lu, J; Wu, C; Zhou, D; Zhou, H; Zhu, Z	1
Jiang, H; Liu, DH; Wang, GN; Zhang, J	1
Chen, S; Jiang, C; Wang, M; Xia, M	1
Arslan, M; Elmas, C; Erer, D; Goktas, G; Iriz, E; Oktar, GL; Ozer, A; Tatar, T; Zor, MH	1
Alkan, M; Arslan, M; Comu, FM; Kip, G; Kiraz, HA; Ozer, A; Sivgin, V	1
Alkan, M; Arslan, M; Bilge, M; Çelik, A; Erdem, Ö; Kavutçu, M; Kip, G; Kiraz, HA; Özer, A; Şıvgın, V	1
Davidson, SM; Fuenzalida, B; Hall, AR; Ibacache, M; Lavandero, S; Pedrozo, Z; Riquelme, JA; Sánchez, G; Sobrevia, L; Vicencio, JM; Westermeier, F; Yellon, DM	1
Cheng, XY; Gao, Q; Gu, XY; Li, XH; Zhang, Y; Zong, QF	1
Ji, FH; Meng, XW; Peng, K; Zhang, J; Zhang, JJ	1
Adachi, YU; Katoh, T; Mimuro, S; Sano, H; Sato, S; Suzuki, A; Uraoka, M; Yu, S	1
Cho, S; Hara, T; Maekawa, T; Shibata, I; Sumikawa, K; Ureshino, H; Yoshitomi, O	1
Kurita, T; Mochizuki, T; Morita, K; Okada, H; Sato, S	1

Reviews

1 review(s) available for dexmedetomidine and Injury, Myocardial Reperfusion

Article	Year
The effect of dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:23 Topics: Adrenergic alpha-2 Receptor Agonists; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Creatine Kinase, MB Form; Dexmedetomidine; Humans; Intensive Care Units; Length of Stay; Myocardial Reperfusion Injury	2021

Article

Year

The effect of dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis.

European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:23

Topics: Adrenergic alpha-2 Receptor Agonists; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Creatine Kinase, MB Form; Dexmedetomidine; Humans; Intensive Care Units; Length of Stay; Myocardial Reperfusion Injury

2021

Trials

2 trial(s) available for dexmedetomidine and Injury, Myocardial Reperfusion

Article	Year
Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat. Life sciences, 2020, Sep-15, Volume: 257 Topics: Acute Kidney Injury; Aged; Animals; Apoptosis; China; Dexmedetomidine; Endoplasmic Reticulum Stress; Female; Humans; Ischemia; Kidney; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2020
Effects of Pre-Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study. Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:2 Topics: Aged; Anti-Inflammatory Agents; Biomarkers; Cardiopulmonary Bypass; China; Cytokines; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Inflammation; Inflammation Mediators; Male; Malondialdehyde; Middle Aged; Myocardial Reperfusion Injury; Pilot Projects; Prospective Studies; Sevoflurane; Superoxide Dismutase; Time Factors; Treatment Outcome; Troponin I	2019

Article

Year

Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.

Life sciences, 2020, Sep-15, Volume: 257

Topics: Acute Kidney Injury; Aged; Animals; Apoptosis; China; Dexmedetomidine; Endoplasmic Reticulum Stress; Female; Humans; Ischemia; Kidney; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2020

Effects of Pre-Cardiopulmonary Bypass Administration of Dexmedetomidine on Cardiac Injuries and the Inflammatory Response in Valve Replacement Surgery With a Sevoflurane Postconditioning Protocol: A Pilot Study.

Journal of cardiovascular pharmacology, 2019, Volume: 74, Issue:2

Topics: Aged; Anti-Inflammatory Agents; Biomarkers; Cardiopulmonary Bypass; China; Cytokines; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Inflammation; Inflammation Mediators; Male; Malondialdehyde; Middle Aged; Myocardial Reperfusion Injury; Pilot Projects; Prospective Studies; Sevoflurane; Superoxide Dismutase; Time Factors; Treatment Outcome; Troponin I

2019

Other Studies

73 other study(ies) available for dexmedetomidine and Injury, Myocardial Reperfusion

Article	Year
Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway. Arquivos brasileiros de cardiologia, 2021, Volume: 117, Issue:6 Topics: Animals; Dexmedetomidine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Reperfusion Injury; Signal Transduction	2021
Dexmedetomidine Attenuates Hypoxia/Reoxygenation Injury of H9C2 Myocardial Cells by Upregulating miR-146a Expression via the MAPK Signal Pathway. Pharmacology, 2022, Volume: 107, Issue:1-2 Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Dexmedetomidine; Endoplasmic Reticulum Stress; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Reperfusion Injury; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Up-Regulation	2022
Effects of dexmedetomidine on the degree of myocardial ischemia-reperfusion injury, oxidative stress and TLR4/NF-κB signaling pathway in rats. Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:5(Special) Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Dexmedetomidine; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4	2021
Dexmedetomidine protects cardiomyocytes against hypoxia/reoxygenation injury via multiple mechanisms. Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:7 Topics: Apoptosis; Catalase; Dexmedetomidine; Humans; Hypoxia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress	2022
Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered, 2022, Volume: 13, Issue:1 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Dexmedetomidine; Disease Models, Animal; Forkhead Box Protein O3; Male; Mice; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Rats; Signal Transduction; Tumor Suppressor Protein p53	2022
Dexmedetomidine post-conditioning alleviates myocardial ischemia-reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation. Human cell, 2022, Volume: 35, Issue:3 Topics: Animals; Dexmedetomidine; Ferroptosis; Lipid Peroxides; Myocardial Reperfusion Injury; Myocardium; Rats	2022
Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells. Bioengineered, 2022, Volume: 13, Issue:4 Topics: Apoptosis; Cell Proliferation; Dexmedetomidine; Humans; Hypoxia; Inflammation; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Proto-Oncogene Proteins c-akt	2022
Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1α. Brazilian journal of cardiovascular surgery, 2022, 05-23, Volume: 37, Issue:3 Topics: Acute Lung Injury; Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Signal Transduction	2022
Dexmedetomidine Mitigates Myocardial Ischemia/Reperfusion-Induced Mitochondrial Apoptosis through Targeting lncRNA HCP5. The American journal of Chinese medicine, 2022, Volume: 50, Issue:6 Topics: Apoptosis; Dexmedetomidine; Humans; MicroRNAs; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; RNA, Long Noncoding	2022
Role of Keap1-Nrf2/ARE signal transduction pathway in protection of dexmedetomidine preconditioning against myocardial ischemia/reperfusion injury. Bioscience reports, 2022, 09-30, Volume: 42, Issue:9 Topics: Animals; Antioxidants; Carboxylic Ester Hydrolases; Dexmedetomidine; Kelch-Like ECH-Associated Protein 1; Male; Myocardial Reperfusion Injury; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Signal Transduction	2022
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 154 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Dexmedetomidine; Ferroptosis; Glycogen Synthase Kinase 3 beta; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley	2022
Dexmedetomidine reduces myocardial ischemia-reperfusion injury in young mice through MIF/AMPK/GLUT4 axis. BMC anesthesiology, 2022, 09-14, Volume: 22, Issue:1 Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; bcl-2-Associated X Protein; Dexmedetomidine; Interleukin-6; Macrophage Migration-Inhibitory Factors; Mice; Myocardial Reperfusion Injury; Necrosis; Proto-Oncogene Proteins c-bcl-2; Tumor Necrosis Factor-alpha	2022
Effects of electroacupuncture with dexmedetomidine on myocardial ischemia/reperfusion injury in rats. Annals of palliative medicine, 2022, Volume: 11, Issue:9 Topics: Adenosine Triphosphate; Animals; Dexmedetomidine; Electroacupuncture; Male; Malondialdehyde; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase	2022
Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats. Redox report : communications in free radical research, 2023, Volume: 28, Issue:1 Topics: Animals; Apoptosis; Dexmedetomidine; Male; Myocardial Reperfusion Injury; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Sirtuin 3; Superoxide Dismutase	2023
Effect and mechanisms of dexmedetomidine combined with macrophage migration inhibitory factor inhibition on the expression of inflammatory factors and AMPK in mice. Clinical and experimental immunology, 2023, 04-07, Volume: 212, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Dexmedetomidine; Macrophage Migration-Inhibitory Factors; Mice; Myocardial Reperfusion Injury; Reactive Oxygen Species	2023
Dexmedetomidine alleviates myocardial ischemia-reperfusion injury by down-regulating miR-34b-3p to activate the Jagged1/Notch signaling pathway. International immunopharmacology, 2023, Volume: 116 Topics: Animals; Apoptosis; Dexmedetomidine; Jagged-1 Protein; MicroRNAs; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Receptors, Notch; Signal Transduction	2023
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway. Molecular and cellular probes, 2023, Volume: 68 Topics: Apoptosis; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dexmedetomidine; Ferroptosis; Humans; Myocardial Reperfusion Injury	2023
Efficacy of dexmedetomidine on myocardial ischemia/reperfusion injury in patients undergoing cardiac surgery with cardiopulmonary bypass: A protocol for systematic review and meta-analysis. Medicine, 2023, Mar-03, Volume: 102, Issue:9 Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dexmedetomidine; Humans; Meta-Analysis as Topic; Myocardial Reperfusion Injury; Review Literature as Topic; Systematic Reviews as Topic	2023
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling. Anesthesia and analgesia, 2023, 08-01, Volume: 137, Issue:2 Topics: Animals; Apoptosis; Creatine Kinase, MB Form; Dexmedetomidine; Disease Models, Animal; Hypoxia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Receptors, Adrenergic, alpha; Reperfusion Injury; Signal Transduction	2023
Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 165 Topics: Animals; Apoptosis; Cell Line; Dexmedetomidine; MEF2 Transcription Factors; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-E2-Related Factor 2; Pyroptosis; Rats; Reperfusion Injury	2023
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF-κB. Chemical biology & drug design, 2023, Volume: 102, Issue:5 Topics: Animals; Dexmedetomidine; Infarction; Inflammation; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2023
DEXMEDETOMIDINE AMELIORATES ACUTE BRAIN INJURY INDUCED BY MYOCARDIAL ISCHEMIA-REPERFUSION VIA UPREGULATING THE HIF-1 PATHWAY. Shock (Augusta, Ga.), 2023, Nov-01, Volume: 60, Issue:5 Topics: Animals; Brain Injuries; Coronary Artery Disease; Dexmedetomidine; Humans; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction	2023
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway. Drug design, development and therapy, 2023, Volume: 17 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Dexmedetomidine; Inflammation; Ischemia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion Injury; Signal Transduction; Sirtuin 3	2023
Dexmedetomidine Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury in Rats by Suppressing Mitophagy Via Activating Α2-Adrenergic Receptor. Arquivos brasileiros de cardiologia, 2023, Volume: 120, Issue:10 Topics: Animals; Beclin-1; Dexmedetomidine; Mitophagy; Myocardial Infarction; Myocardial Reperfusion Injury; Protein Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Adrenergic; Reperfusion Injury; Ubiquitin-Protein Ligases	2023
Characteristics of Dexmedetomidine Postconditioning in the Field of Myocardial Ischemia-Reperfusion Injury. Anesthesia and analgesia, 2020, Volume: 130, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Isolated Heart Preparation; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Time Factors; Ventricular Function, Left	2020
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Dexmedetomidine; Disease Models, Animal; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Protective Agents; Rats; Rats, Sprague-Dawley	2020
Dexmedetomidine and Cardiac "Postconditioning": Clearing the Dex for Clinical Application. Anesthesia and analgesia, 2020, Volume: 130, Issue:1 Topics: Dexmedetomidine; Heart; Humans; Myocardial Reperfusion Injury	2020
Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress. Journal of diabetes research, 2019, Volume: 2019 Topics: Animals; Apoptosis; Cell Line; Creatine Kinase, MB Form; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Fibrosis; Heat-Shock Proteins; Male; Membrane Glycoproteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Disulfide-Isomerases; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor CHOP; Troponin T	2019
Dexmedetomidine reduces myocardial ischemia-reperfusion injury in rats through PI3K/AKT/GSK-3β signaling pathway. Minerva cardioangiologica, 2020, Volume: 68, Issue:1 Topics: Animals; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Hypnotics and Sedatives; Inflammation; Myocardial Reperfusion Injury; Oncogene Protein v-akt; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction	2020
Dexmedetomidine protects H9C2 against hypoxia/reoxygenation injury through miR-208b-3p/Med13/Wnt signaling pathway axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 125 Topics: Apoptosis; Cell Line; Cell Survival; Dexmedetomidine; Gene Expression Regulation; Genes, Reporter; Humans; Hypoxia; Mediator Complex; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Reperfusion Injury; Wnt Signaling Pathway	2020
Dexmedetomidine alleviates H Molecular biology reports, 2020, Volume: 47, Issue:5 Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Death; Cell Line; Cell Survival; Dexmedetomidine; Heme Oxygenase-1; Hydrogen Peroxide; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necroptosis; Oxidative Stress; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Signal Transduction	2020
Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis. Bioscience reports, 2020, 05-29, Volume: 40, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Autophagy; Dexmedetomidine; Disease Models, Animal; Inflammation Mediators; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases	2020
Dexmedetomidine pretreatment protects the heart against apoptosis in ischemia/reperfusion injury in diabetic rats by activating PI3K/Akt signaling in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 127 Topics: Animals; Apoptosis; Cardiotonic Agents; Dexmedetomidine; Diabetes Mellitus, Experimental; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin	2020
Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats. International immunopharmacology, 2020, Volume: 86 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cell Line; Dexmedetomidine; Disease Models, Animal; Down-Regulation; Forkhead Box Protein O3; Humans; Male; MicroRNAs; Myocardial Reperfusion Injury; Myocardium; Protective Agents; Pyroptosis; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2020
Dexmedetomidine Provides Cardioprotection During Early or Late Reperfusion Mediated by Different Mitochondrial K+-Channels. Anesthesia and analgesia, 2021, Volume: 132, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cardiotonic Agents; Dexmedetomidine; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Potassium Channels; Random Allocation; Rats; Rats, Wistar	2021
Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress. Drug design, development and therapy, 2020, Volume: 14 Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Dexmedetomidine; Endoplasmic Reticulum Stress; Hypnotics and Sedatives; Imidazoles; L-Lactate Dehydrogenase; Myocardial Reperfusion Injury; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Thapsigargin	2020
Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133 Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line; Dexmedetomidine; Disease Models, Animal; Gene Expression Regulation; Interleukin-1 Receptor-Associated Kinases; Male; MicroRNAs; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; TNF Receptor-Associated Factor 6	2021
Dexmedetomidine Protects against Myocardial Ischemia/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway. BioMed research international, 2020, Volume: 2020 Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dexmedetomidine; Heart; Humans; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Perfusion; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Thioredoxins	2020
Dexmedetomidine promotes the recovery of renal function and reduces the inflammatory level in renal ischemia-reperfusion injury rats through PI3K/Akt/HIF-1α signaling pathway. European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:23 Topics: Animals; Dexmedetomidine; Hypnotics and Sedatives; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Injections, Intraperitoneal; Kidney; Kidney Function Tests; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction	2020
Effect of dexmedetomidine and cholinergic anti-inflammatory pathways in myocardial ischemia-reperfusion injury. Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:3(Special) Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cholinergic Agents; Creatine Kinase; Cytokines; Dexmedetomidine; Disease Models, Animal; Inflammation Mediators; L-Lactate Dehydrogenase; Male; Myocardial Reperfusion Injury; Myocardium; Rats, Wistar; Up-Regulation	2020
Dexmedetomidine protects cardiac microvascular endothelial cells from the damage of ogd/r through regulation of the pparδ-mediated autophagy. Microcirculation (New York, N.Y. : 1994), 2021, Volume: 28, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Autophagy; Cells, Cultured; Coronary Circulation; Coronary Vessels; Dexmedetomidine; Endothelium, Vascular; Humans; Microcirculation; Microvessels; Myocardial Reperfusion Injury; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR delta; Protective Agents; Reactive Oxygen Species; Signal Transduction	2021
Upregulated microRNA-381-5p strengthens the effect of dexmedetomidine preconditioning to protect against myocardial ischemia-reperfusion injury in mouse models by inhibiting CHI3L1. International immunopharmacology, 2021, Volume: 92 Topics: Animals; Apoptosis; Chitinase-3-Like Protein 1; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Signal Transduction; Up-Regulation	2021
Up-regulating microRNA-138-5p enhances the protective role of dexmedetomidine on myocardial ischemia-reperfusion injury mice via down-regulating Ltb4r1. Cell cycle (Georgetown, Tex.), 2021, Volume: 20, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Down-Regulation; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardial Reperfusion Injury; Receptors, Leukotriene B4; Up-Regulation	2021
Involvement of GPR30 in protection effect of Dexmedetomidine against myocardial ischemia/reperfusion injury in rat via AKT pathway. Acta biochimica Polonica, 2021, Feb-25, Volume: 68, Issue:1 Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Cells, Cultured; Chromones; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Gene Knockdown Techniques; Male; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Signal Transduction; Transfection	2021
Dexmedetomidine reversed hypoxia/reoxygenation injury-induced oxidative stress and endoplasmic reticulum stress-dependent apoptosis of cardiomyocytes via SIRT1/CHOP signaling pathway. Molecular and cellular biochemistry, 2021, Volume: 476, Issue:7 Topics: Animals; Apoptosis; Cell Line; Dexmedetomidine; Endoplasmic Reticulum Stress; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Rats; Signal Transduction; Sirtuin 1; Transcription Factor CHOP	2021
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation. BMC anesthesiology, 2021, 04-06, Volume: 21, Issue:1 Topics: Analgesics, Non-Narcotic; bcl-2-Associated X Protein; Cell Survival; Coculture Techniques; Cytokines; Dexmedetomidine; Fibroblasts; Furans; Humans; Indenes; Myocardial Reperfusion Injury; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Up-Regulation	2021
miRNA-346-3p/CaMKIId axis: In'DEX'ing a new pharmacological strategy for cardioprotection. International journal of cardiology, 2021, 07-01, Volume: 334 Topics: Calcium; Dexmedetomidine; Humans; MicroRNAs; Myocardial Reperfusion Injury; RNA, Long Noncoding	2021
Dexmedetomidine down-regulates lncRNA MALAT1 to attenuate myocardial ischemia reperfusion-induced injury by increasing miR-346. International journal of cardiology, 2021, 07-01, Volume: 334 Topics: Calcium; Dexmedetomidine; Humans; MicroRNAs; Myocardial Reperfusion Injury; RNA, Long Noncoding	2021
Dexmedetomidine: A potential therapy for myocardial ischemia/reperfusion injury. International journal of cardiology, 2021, 07-15, Volume: 335 Topics: Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury	2021
The circulating LncRNA SNHG15/miR-346 axis may be a potential biomarker of cardiomyocyte apoptosis during myocardial ischemia/reperfusion injury. International journal of cardiology, 2021, 07-01, Volume: 334 Topics: Apoptosis; Biomarkers; Calcium; Dexmedetomidine; Humans; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; RNA, Long Noncoding	2021
Dexmedetomidine preconditioning mitigates myocardial ischemia/reperfusion injury via inhibition of mast cell degranulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 141 Topics: Animals; Apoptosis; Arrhythmias, Cardiac; Cardiotonic Agents; Cell Degranulation; Cell Line; Cell Proliferation; Dexmedetomidine; Hemodynamics; Ischemic Preconditioning; Male; Mast Cells; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley	2021
Dexmedetomidine protects mice against myocardium ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS pathway. Clinical and experimental pharmacology & physiology, 2017, Volume: 44, Issue:9 Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Dexmedetomidine; Mice; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction	2017
Dexmedetomidine Maintains Its Direct Cardioprotective Effect Against Ischemia/Reperfusion Injury in Hypertensive Hypertrophied Myocardium. Anesthesia and analgesia, 2018, Volume: 126, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cardiomegaly; Cardiotonic Agents; Dexmedetomidine; Hypertension; Male; Myocardial Reperfusion Injury; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Treatment Outcome	2018
The effects of dexmedetomidine preconditioning on aged rat heart of ischaemia reperfusion injury. Research in veterinary science, 2017, Volume: 114 Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Dexmedetomidine; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley	2017
[Effect of dexmedetomidine postconditioning on myocardial ischemia-reperfusion injury and inflammatory response in diabetic rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017, Nov-20, Volume: 37, Issue:11 Topics: Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Inflammation; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Sprague-Dawley	2017
Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. Acta cirurgica brasileira, 2018, Volume: 33, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Endothelin-1; Heart Rate; Hemodynamics; Male; Myocardial Reperfusion Injury; No-Reflow Phenomenon; Platelet Activating Factor; Rabbits; Random Allocation; Reference Values; Reproducibility of Results; Thromboxane A2; Treatment Outcome	2018
The cardioprotective effect of dexmedetomidine on regional ischemia/reperfusion injury in type 2 diabetic rat hearts. Microvascular research, 2019, Volume: 123 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arrhythmias, Cardiac; Cytoprotection; Dexmedetomidine; Diabetes Mellitus, Experimental; Glycogen Synthase Kinase 3 beta; Heart Rate; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Rats, Sprague-Dawley; Troponin T	2019
Effects of Dexmedetomidine Postconditioning on Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Role of the PI3K/Akt-Dependent Signaling Pathway. Journal of diabetes research, 2018, Volume: 2018 Topics: Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Glycogen Synthase Kinase 3 beta; Heart; Ischemic Postconditioning; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction	2018
Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation. Cardiovascular drugs and therapy, 2019, Volume: 33, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Cell Death; Cell Hypoxia; Cell Line; Cellular Microenvironment; Cytokines; Dexmedetomidine; HMGB1 Protein; Inflammation Mediators; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Signal Transduction	2019
Identification of Candidate Genes and Pathways in Dexmedetomidine-Induced Cardioprotection in the Rat Heart by Bioinformatics Analysis. International journal of molecular sciences, 2019, Apr-01, Volume: 20, Issue:7 Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cardiotonic Agents; Dexmedetomidine; Dual Specificity Phosphatase 1; Gene Expression Profiling; Heart; Male; MAP Kinase Signaling System; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Transcriptome; Tumor Suppressor Protein p53	2019
Dexmedetomidine attenuates myocardial ischemia/reperfusion injury through regulating lactate signaling cascade in mice. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:8 Topics: Animals; Caspase 3; Caspase 9; Coronary Vessels; Cytochromes c; Dexmedetomidine; Disease Models, Animal; Humans; Lactic Acid; Male; Mice; Mitochondria; Monocarboxylic Acid Transporters; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Signal Transduction; Symporters	2019
Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury. PloS one, 2019, Volume: 14, Issue:7 Topics: Animals; Cardiotonic Agents; Dexmedetomidine; Gene Expression Regulation; HMGB1 Protein; Humans; Interleukin-6; Myocardial Reperfusion Injury; Myocardium; Neuroimmunomodulation; Rats; Signal Transduction; Troponin I; Tumor Necrosis Factor-alpha; Vagotomy	2019
Effects of dexmedetomidine on myocardial ischemia-reperfusion injury through PI3K-Akt-mTOR signaling pathway. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:15 Topics: Animals; Apoptosis; Cardiotonic Agents; Creatine Kinase; Dexmedetomidine; Disease Models, Animal; Free Radicals; Humans; Male; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases	2019
[Dexmedetomidine preconditioning protects isolated rat hearts against ischemia/reperfusion injuries and its mechanism]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013, Volume: 42, Issue:3 Topics: Animals; Dexmedetomidine; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Potassium Channels; Rats; Rats, Sprague-Dawley	2013
The protective effects of dexmedetomidine on liver injury-induced myocardial ischemia reperfusion. Bratislavske lekarske listy, 2014, Volume: 115, Issue:7 Topics: Animals; Coronary Vessels; Dexmedetomidine; Humans; Liver; Liver Diseases; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Protective Agents; Rats; Rats, Wistar	2014
Effect of dexmedetomidine on erythrocyte deformability during ischaemia-reperfusion injury of heart in diabetic rats. Bratislavske lekarske listy, 2014, Volume: 115, Issue:8 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Erythrocyte Deformability; Male; Myocardial Reperfusion Injury; Rats, Wistar	2014
Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats. The Libyan journal of medicine, 2015, Volume: 10, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Glutathione Transferase; Lung; Lung Injury; Male; Malondialdehyde; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Rats; Rats, Wistar	2015
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism. Pharmacological research, 2016, Volume: 103 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cardiotonic Agents; Cells, Cultured; Coculture Techniques; Dexmedetomidine; Endothelial Cells; Heart; Humans; Male; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Sprague-Dawley	2016
Effects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injury. Molecular medicine reports, 2016, Volume: 14, Issue:1 Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Cardiotonic Agents; Caspase 3; Creatine Kinase, MB Form; Dexmedetomidine; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; RNA, Messenger; Signal Transduction; Superoxide Dismutase	2016
Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway. PloS one, 2017, Volume: 12, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Down-Regulation; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Male; Myeloid Differentiation Factor 88; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4	2017
Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation, 2010, Volume: 81, Issue:12 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Coronary Circulation; Dexmedetomidine; Hemodynamics; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Yohimbine	2010
Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs. Shock (Augusta, Ga.), 2012, Volume: 38, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Circulation; Dexmedetomidine; Drug Evaluation, Preclinical; Female; Hemodynamics; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Norepinephrine; Sus scrofa	2012
The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearts. Resuscitation, 2007, Volume: 74, Issue:3 Topics: Adrenergic alpha-Agonists; Animals; Coronary Circulation; Dexmedetomidine; Disease Models, Animal; Heart Arrest; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Treatment Outcome; Ventricular Function, Left	2007