dexmedetomidine has been researched along with Injury, Ischemia-Reperfusion in 176 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (2.27) | 29.6817 |
| 2010's | 95 (53.98) | 24.3611 |
| 2020's | 77 (43.75) | 2.80 |
| Authors | Studies |
|---|---|
| Du, H; Jia, L; Lyu, J; Sheng, M; Yu, H; Yu, W | 1 |
| Leng, Y; Liu, X; Lv, J; Lv, X; Shi, Y; Zhang, M | 1 |
| Cheng, WJ; Li, HZ; Li, Z; Liu, X; Shi, N; Wang, XL; Zhao, S | 1 |
| Cao, S; Chen, H; Chen, Y; Xu, X; Yang, Z; Yin, C | 1 |
| Cui, LL; Li, N; Xue, FS; Zhang, L; Zhu, ZJ | 1 |
| Cheng, G; Li, Y; Qiu, G; Wang, Y; Wu, W; Wu, Y; Zhang, H; Zhu, L | 1 |
| Han, H; Liu, W; Nie, H; Tian, K; Wang, N; Wang, S; Zhang, Y | 1 |
| Chen, QH; Hu, Q; Huang, YL; Liu, XM; Liu, ZR; Liu, ZY; Wang, WX; Zhang, HG; Zhang, Q; Zhang, XK | 1 |
| Chang, ZN; Guo, Y; Lai, HJ; Liu, ZM; Wen, SH; Zhan, YQ; Zhang, HF; Zhang, XY; Zhang, YN | 1 |
| Xu, XL; Yang, B | 1 |
| Chen, QH; Hu, Q; Huang, YL; Liu, XM; Liu, ZR; Liu, ZY; Wang, WX; Zhang, HG; Zhang, Q; Zhang, X | 1 |
| Chan, WS; Chao, A; Chen, CC; Chiu, CT; Lee, CY; Tsai, MK; Wang, MJ; Wang, YC; Yeh, YC | 1 |
| Lai, S; Li, G; Liu, Q; Wu, J | 1 |
| Huang, W; Liang, Y; Liu, B; Xiao, X; Zhang, H; Zhou, D | 1 |
| Liu, C; Xu, R | 1 |
| Chen, L; Dong, S; Duan, F; Hu, M; Huang, J; Men, Y; Zhang, Y | 1 |
| Ergene, S; Hemsinli, D; Karakisi, SO; Mercantepe, T; Tumkaya, L; Yilmaz, A | 2 |
| Cui, X; Ge, S; Li, Y; Zhang, L | 1 |
| He, J; Jiang, L; Li, J; Liu, H; Wang, K; Zhang, H | 1 |
| Arslan, M; Dursun, AD; Kavutçu, M; Köksal, Z; Kurtipek, Ö; Şengel, N; Sezen, ŞC | 1 |
| Li, G; Liu, B; Wei, J; Zhou, J | 1 |
| Fan, Y; Fu, Z; He, L; Pang, Z; Yang, J; Zhang, L; Zhao, C | 1 |
| Cong, D; Meng, Y; Qi, X; Yu, Y | 1 |
| Gao, Y; He, Z; Su, H; Wang, L; Wu, H; Yan, S; Zhang, H | 1 |
| Ding, C; Han, GJ; Ma, SS; Min, XZ; Wang, XQ | 1 |
| Liu, G; Ou, Y; Yang, Y; Yin, F; Zhang, F | 1 |
| Chen, PS; Chen, YG; Cheng, Y; Hao, PP; Hu, B; Jiang, TY; Li, XT; Liu, WC; Tian, T; Xue, FS | 1 |
| Li, X; Ning, X; Sun, C; Tang, J; Wang, J; Zhang, N; Zhang, S | 1 |
| Chen, ZR; Hong, Y; Huang, WQ; Wen, SH; Zhan, YQ | 1 |
| Guo, Q; Han, Y; Ma, M; Yu, H; Zhang, D | 1 |
| He, J; Li, J; Liu, H; Liu, M; Wang, K; Zhang, H | 1 |
| Bao, X; Huang, L; Lyu, J; Sun, Z; Tang, L; Zhang, M; Zhao, L; Zhou, Y | 1 |
| Bai, X; Dai, N; Liu, J; Qian, J; Qian, X; Wang, L; Wang, Q; Wang, Z; Xie, Y; Yang, W; Yang, Y; Zeng, W; Zhao, Y | 1 |
| Chen, H; Du, L; Gao, W; Li, N; Li, Y; Wu, J; Zhang, Z | 1 |
| Chen, S; Cheng, H; Wang, J; Wu, J; Yang, X | 1 |
| Chen, F; Han, X; He, Y; Hou, M; Leng, Y; Shi, Y; Tan, Z; Xu, Y | 1 |
| He, H; Li, P; Liu, P | 1 |
| Chen, H; Chen, Y; Xu, W; Yang, Z; Zhou, T | 1 |
| Li, S; Liu, J; Wen, Q; Xie, K; Yu, J; Yu, L; Zhu, Y | 1 |
| Kinoshita, H; Morita, Y | 1 |
| Ji, Z; Liang, G; Wang, L; Wang, S | 1 |
| Cao, G; Zhang, E | 1 |
| Choi, YS; Kim, SH | 1 |
| Li, P; Liu, H; Zhang, Y | 1 |
| Cao, Y; Guo, H; Li, P; Liu, C; Wang, D; Yang, X; Zhai, M; Zhao, L | 1 |
| Chen, Y; Luo, C; Zhou, Q; Zhu, C | 1 |
| Cao, J; Liu, M; Mi, W; Yang, Y; Zhang, Y | 1 |
| Li, Y; Liu, C; Wang, J; Yu, Z; Zhai, M; Zhang, L; Zhang, P; Zhang, Q; Zhu, H | 1 |
| Echavarría, R; Figueroa, F; Franco-Acevedo, A; Garcia, D; Goldaraz-Monraz, MP; Melo, Z; Moreno-Carranza, B; Palomino, J; Portilla-Debuen, E | 1 |
| Cheng, W; Liu, P; Liu, X; Wang, M; Wang, X; Zhao, S | 1 |
| Deng, H; Liu, J; Xie, K; Yu, J; Yu, L; Zhai, Y; Zhu, Y | 1 |
| Kong, GY; Pan, BB; Pei, WM; Zhang, QQ; Zhao, Y; Zhou, B | 1 |
| Bian, W; Chen, Y; Xu, B | 1 |
| Liu, L; Qian, J; Song, N; Wang, Z; Xiong, W; Yang, Y; Zhou, R | 1 |
| Chen, QH; Hu, Q; Liang, SS; Liu, XM; Liu, Z; Wu, Q; Zhang, HG; Zhang, Q; Zhang, XK | 1 |
| Hopster, K; Kästner, SBR; König, KS; Neudeck, S; Pfarrer, C; Rohn, K; Verhaar, N | 1 |
| Acar, M; Erdem, AF; Özdin, M; Sayhan Kaplan, H; Tomak, Y; Turan, G | 1 |
| Fang, M; He, J; Li, W; Lin, D; Ma, X | 1 |
| Chai, X; Gao, J; Geng, Q; Hu, Y; Jiang, J; Liang, X; Shi, S; Tang, C; Wang, J | 1 |
| Gao, H; Hu, BL; Li, YP; Yin, YQ; Zhong, Y | 1 |
| Chen, Y; Huang, Y; Luo, H; Song, X; Xiong, B | 1 |
| Liu, J; Liu, X; Lv, C; Shen, Q; Wang, L; Xu, G; Yu, Y; Zhou, Y | 1 |
| Engiles, JB; Hopster, K; Kästner, SBR; Kopp, V; VanderBroek, AR; Verhaar, N | 1 |
| Dong, S; Hu, M; Jiang, M; Liu, G; Men, Y; Sun, Z; Tong, X; Wang, X | 1 |
| Akbulut, A; Gürsoy, K; Kırtıl, G; Koca, G; Korkmaz, M; Kotanoğlu, MS; Özcan, N; Şenes, M; Yumuşak, N | 1 |
| An, M; Deni, W; Hou, L; Jin, K; Ta Na, HS; Zhang, T | 1 |
| Cai, X; Huang, W; Li, Y; Wang, Q; Wang, Z; Ye, F; Zheng, X; Zuo, Z | 1 |
| Davis, JRJ; Wu, ZL; Zhu, Y | 1 |
| Cheng, M; Dong, W; Huang, G; Yang, H; Yin, J; Zeng, Z; Zhang, X | 1 |
| Deng, H; Jia, J; Tu, W; Wu, Y; Xi, W; Xu, Y; Yang, J | 1 |
| Deresoy, FA; Firat, F; Katar, M; Kölükçü, E; Kölükçü, V; Kuyucu, YE; Parlaktaş, BS; Unsal, V | 1 |
| Chen, F; Jiang, Y; Li, X; Ma, H; Wang, D; Wang, H | 1 |
| Delen, LA; Gulaboglu, M; Kuyrukluyildiz, U; Onk, D; Suleyman, H; Yazici, GN | 1 |
| Luo, Y; Ma, J; Tang, J; Wan, W; Xiao, J; Yan, L; Zhang, Y | 1 |
| Cahilog, Z; Cao, J; Chen, Q; Chen, X; Chen, Y; Gu, J; Hu, L; Lu, K; Lu, S; Ning, J; Yi, B | 1 |
| Liu, Y; Ma, XG; Xue, MX | 1 |
| Cheng, D; Li, H; Li, Y; Qu, M; Xing, F; Xing, N; Zhang, W | 1 |
| Hao, S; Ling, Y; Liu, J; Yu, S; Zhao, Q | 1 |
| Liu, Y; Ma, X; Zhang, W; Zhao, H; Zhu, Y | 1 |
| Ainiwaer, Y; Geng, Q; He, B; Li, X; Lin, L; Zhang, B; Zhang, J | 1 |
| Ai, Y; He, L; Li, D; Zhang, S; Zhao, B | 1 |
| Cai, Y; Hong, H; Huang, Q; Jin, Z; Lin, T; Xia, F | 1 |
| Liu, W; Shao, C; Sun, J; Wang, Y; Xu, M; Zang, C | 1 |
| Alaybeyoğlu, F; Dumlu, EG; Erkılıç, E; Gümüş, T; Kanbak, O; Kesimci, E; Kılınç, I; Sepici Dinçel, A; Tural, R; Yazgan, A | 1 |
| Kim, E; Kim, HC; Kim, JH; Lee, S; Lim, YJ; Park, HP; Park, YH; Ryu, HG | 1 |
| Arslan, M; Aydın, ME; Bayraktar, AC; Erbatur, ME; Kavutçu, M; Sezen, ŞC | 1 |
| Bo, Z; Hong, C; Huaxin, W; Shaoqing, L; Yayi, H; Yeda, X; Zhongyuan, X | 1 |
| Fu, Z; Lin, S; Shao, W; Zhou, G | 1 |
| Chen, Z; Ma, CG; Qiu, PY | 1 |
| Duan, L; Liu, Z; Wang, GM; Wang, SL; Wang, Y; Xia, B | 1 |
| Akan, M; Balcı, C; Boztaş, N; Ergür, BU; Güneli, ME; Özkardeşler, S; Ünal, B | 1 |
| Chen, WR; Gao, JM; Ji, FH; Meng, XW; Peng, K; Xia, F; Zhang, J | 1 |
| Pang, Q; Wang, Z; Zhou, W; Zhou, X; Zhou, Y | 1 |
| Han, XP; Jia, YP; Li, ZC; Qi, JL; Wang, Y | 1 |
| Alam, A; Chen, Q; Gu, J; He, X; Li, J; Lu, K; Ning, J; Yi, B | 1 |
| Chen, C; Chen, X; Han, M; Li, J; Li, Q | 1 |
| Chen, Q; Li, Z; Wan, L; Wu, Z; Zheng, D; Zhou, Z | 1 |
| Fang, ZX; Gao, H; Luo, ZY; Wang, WT; Xiang, BQ | 1 |
| Cheng, J; Li, X; Peng, X; Qin, H; Yu, H; Zhu, P | 1 |
| Gao, GJ; Gu, PF; Li, Y; Shang, Y; Xue, Q | 1 |
| Dai, J; Fan, X; Hu, J; Liu, J; Yuan, F; Zhang, S | 1 |
| Gao, Y; Lv, S; Masters, J; Sun, Z; Weng, H; Zhao, T | 1 |
| Dong, H; He, Z; Ma, X; Wang, Z; Zhou, W | 1 |
| Choi, YS; Jun, JH; Kim, SH; Oh, JE; Oh, YJ; Shin, EJ | 1 |
| Fang, T; Fu, Q; Liu, C; Mu, R; Tian, F; Wang, F; Yu, B; Zhang, L; Zhang, Y; Zhou, C | 1 |
| Choi, YS; Kim, DH; Kim, SH; Kim, SJ; Kim, TL; Shin, S | 1 |
| Ding, M; Li, JY; Ren, HC; Wang, G; Wang, Q; Weng, YQ; Xu, RB; Yu, HL; Yu, WL | 1 |
| Chen, Q; Chen, Y; Gu, J; Li, J; Lu, K; Ma, D; Ma, J; Mi, E; Ning, J; Yi, B; Zhao, H | 1 |
| Bao, H; Chen, L; Geng, Y; Han, L; Jing, L; Si, Y; Xing, Y; Zeng, L | 1 |
| Abad-Gurumeta, A; Calvo-Vecino, JM; Gómez-Ríos, MÁ | 1 |
| Liang, S; Liu, Y; Wang, Y | 1 |
| Chen, Q; Chen, S; Jia, C; Jiang, H; Liu, X; Wang, D; Xu, Z; Zhang, D; Zhou, Z | 1 |
| Chen, W; Teng, L; Yin, C; Zhang, H; Zhao, Q | 1 |
| Cao, D; Cao, J; Chen, L; Cong, H; Wang, M; Xiang, H; Yang, Y; Ying, T | 1 |
| Meng, QT; Nuo, M; Xia, ZY | 1 |
| Chen, Y; Dai, JC; Du, J; Fan, X; Li, JM; Wang, MH; Yang, B; Zhang, C; Zhou, J | 1 |
| Dong, Y; Gao, Y; Liu, H; Wu, X; Yang, F; Yin, H; Zhang, Y | 1 |
| Chen, BH; Lin, LN; Tang, YN; Weng, CW; Xue, BB | 1 |
| Hwang, JW; Jeon, YT; Lim, YJ; Park, HP; Park, SK | 1 |
| Alkanat, M; Besir, A; Cekic, B; Geze, S; Yulug, E | 1 |
| Okabe, T; Sakamoto, A; Sugita, S | 1 |
| Bao, H; Han, L; Liu, C; Ma, D; Shi, H; Si, Y; Vohra, A; Wang, J; Xu, L; Yang, X; Zhang, Y | 1 |
| Dong, X; Han, X; Li, Y; Sun, L; Xing, Q | 1 |
| Bell, MT; Bennett, DT; Fullerton, DA; Herson, PS; Puskas, F; Quillinan, N; Reece, TB | 1 |
| Guo, L; Jiang, L; Li, L; Qi, Z; Shen, J | 1 |
| Besir, A; Cekic, B; Geze, S; Karahan, SC; Mentese, A; Ozkan, G; Sonmez, M | 1 |
| Arikan, S; Gencer, B; Hanci, V; Kara, S; Karaboga, I; Karaca, T; Toman, H; Tufan, HA | 1 |
| Cai, Y; Lu, Y; Xu, H; Yan, J; Zhang, L | 1 |
| Deng, LH; Hua, YP; Huang, CY; Huang, WQ; Liu, KX; Wang, ZX | 1 |
| Bao, HG; Shen, Y; Si, YN; Wang, JS; Wang, XL; Xu, L; Yang, XB | 1 |
| Barsoum, S; Chi, OZ; Dinani, A; Grayson, J; Liu, X; Weiss, HR | 1 |
| Arslan, M; Cavunt-Bayraktar, A; Comu, FM; Kavutcu, M; Kucuk, A; Tosun, M; Yaylak, F | 1 |
| Bell, MT; Cleveland, JC; Foley, LS; Freeman, KA; Fullerton, DA; Mares, J; Meng, X; Puskas, F; Reece, TB; Weyant, MJ | 1 |
| Dong, J; Tang, J; Yang, L; Zheng, J | 1 |
| Chen, H; Liu, L; Liu, X; Wang, H; Wang, L; Wang, M | 1 |
| Cai, J; Hei, Z; Luo, C; Yao, W; Yuan, D; Zhang, Y; Zhou, S | 1 |
| Braz, JR; Braz, LG; Castiglia, YM; de Carvalho, AL; Domingues, MA; Kakuda, CM; Módolo, MP; Módolo, NS; Ribeiro, OR; Vital, RB | 1 |
| Li, R; Yao, W; Yu, J | 1 |
| Bell, MT; Cleveland, JC; Foley, LS; Freeman, KA; Fullerton, DA; Herson, PS; Mares, JM; Meng, X; Puskas, F; Reece, TB; Weyant, MJ | 1 |
| Cakir, M; Polat, A; Rumeysa Duran, Z; Tanbek, K; Taslidere, E; Tekin, S; Vardi, N | 1 |
| Bi, B; Fang, B; Li, XQ; Liu, G; Ma, H; Tan, WF; Zhang, Y | 1 |
| Atasoy, P; Batislam, E; Gencay, IY; Kisa, U; Tuglu, D; Yilmaz, E; Yuvanc, E | 1 |
| Atasoy, P; Bal, F; Batislam, E; Kisa, U; Ozan, T; Tuglu, D; Yilmaz, E; Yuvanc, E | 1 |
| Li, T; Li, Y; Liang, J; Xiao, J; Xie, C; Zhao, Z | 1 |
| He, A; Huang, L; Liu, G; Qiu, L; Song, H; Tong, F; Wan, Q; Wang, X; Xia, Y | 1 |
| Ehsan, NA; Elfert, AY; Fayed, NA; Saleh, SM; Sayed, EI | 1 |
| Li, W; Wang, H; Wang, Q; Xing, X; Zeng, X | 1 |
| Aksoy, N; Aydogan, H; Büyükfirat, E; Karahan, MA; Kocarslan, S; Kücük, A; Taskın, A; Yalcin, S; Yüce, HH | 1 |
| Bao, HG; Chen, LH; Han, L; Pan, XX; Si, YN; Sun, F; Xu, YJ; Zeng, LQ; Zhang, Y | 1 |
| Cai, J; Chi, X; Ge, M; Wang, Y; Wu, S; Yu, X; Zhou, S | 1 |
| Meng, FM; Xue, FS; Zhang, JQ; Zhang, W | 1 |
| Chen, Q; Gu, J; Lu, K; Ma, D; Ma, J; Ning, J; Wu, L; Yi, B | 1 |
| Akpınar, H; Akpınar, O; Çiğ, B; Nazıroğlu, M; Övey, İS | 1 |
| Chen, JT; Chen, RM; Chen, TL; Liu, SH; Tsai, HC; Wu, GJ | 1 |
| Li, Y; Liu, S | 1 |
| Gulcu, N; Kocoglu, H; Ozturk, H; Yilmaz, F | 1 |
| Nakano, T; Okamoto, H | 1 |
| Bektaş, S; Can, M; Erol, B; Hanci, V; Mungan, G; Ozkoçak Turan, I; Tokgöz, H; Yurtlu, S | 1 |
| Braz, JR; Castiglia, YM; Curtis, FG; Fiorio, PM; Oliveira, C; Silva, LM; Vianna, PT; Viero, RM | 1 |
| Gu, J; Ma, D; Maze, M; Sanders, RD; Sun, P; Terrando, N; Watts, HR; Xia, P; Zhao, H | 1 |
| Chen, J; Gu, J; Ma, D; Tao, G; Xia, P; Zhao, H | 1 |
| Díaz-Araya, G; Duaso, J; Echevarria, G; Galvez, F; Garcia, L; Hassi, M; Humeres, C; Ibacache, M; Lavandero, S; Pedrozo, Z; Sanchez, G | 1 |
| Huang, WQ; Li, Y; Li, YS; Liu, KX; Liu, ZM; Wen, SH; Yao, X; Zhang, XY | 1 |
| Citil, M; Hanci, V; Kiliç, K; Kiliç, N; Selek, S; Sözmen, M; Yurtlu, BS; Yurtlu, DA | 1 |
| Agoston, VA; Bell, MT; Fullerton, DA; Meng, X; Puskas, F; Reece, TB; Smith, PD; Weyant, MJ | 1 |
| Afyoncu, E; Başar, H; Cuzdan, SS; Fidancı, V; Gülbahçe, R; Kayıran, O; Üstün, H; Uysal, HY | 1 |
| Arslan, M; Comu, FM; Isik, B; Kesimci, E; Ozturk, L | 1 |
| Chen, L; Ma, LL; Qian, LB; Wang, CC; Wen, CY; Yan, M; Yu, J; Yu, LN; Zhu, MH; Zhu, YM | 1 |
| Akcay, F; Calik, M; Cetin, N; Gundogdu, C; Ingec, M; Isaoglu, U; Kurt, A; Polat, B; Suleyman, H; Yilmaz, M | 1 |
| Alabalik, U; Aliosmanoglu, I; Çiftçi, T; Evliyaoglu, O; Güzel, A; Tokgöz, O; Tüfek, A; Yıldırım, ZB | 1 |
| Begeç, Z; Durmuş, M; Ersoy, MÖ; Polat, A; Sahin, T; Toprak, Hİ; Vardi, N; Yücel, A | 1 |
| Ayoglu, H; Bostankolu, E; Can, M; Deniz, Y; Erdogan, G; Hanci, V; Okyay, RD; Turan, IO; Yurtlu, S | 1 |
| Bachl, M; Blobner, M; Eberspächer, E; Engelhard, K; Hildt, E; Hutzler, P; Kochs, E; Werner, C | 1 |
| Haapalinna, A; Kuhmonen, J; Sivenius, J | 1 |
2 review(s) available for dexmedetomidine and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Dexmedetomidine against intestinal ischemia/reperfusion injury: A systematic review and meta-analysis of preclinical studies.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Inflammation; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia/reperfusion injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium; Dexmedetomidine; Humans; Inflammation; Ion Channels; Molecular Targeted Therapy; Oxidative Stress; Reactive Oxygen Species; Regional Blood Flow; Reperfusion Injury; Signal Transduction | 2014 |
12 trial(s) available for dexmedetomidine and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Effects of perioperative dexmedetomidine infusion on renal function and microcirculation in kidney transplant recipients: a randomised controlled trial.
Topics: Bradycardia; Creatinine; Dexmedetomidine; Humans; Hypotension; Kidney; Kidney Transplantation; Microcirculation; Reperfusion Injury | 2022 |
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury.
Topics: Adrenergic Agonists; Alveolar Epithelial Cells; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Dexmedetomidine; Glutathione; Inflammation; Malondialdehyde; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
[Protective effect of ulinastatin combined with dexmedetomidine against hepatic ischemia-reperfusion injury in laparoscopic hepatectomy for liver cancer and cirrhosis: a randomized controlled trial].
Topics: Dexmedetomidine; Hepatectomy; Humans; Interleukin-6; Laparoscopy; Liver Cirrhosis; Liver Neoplasms; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine exerts a protective effect on ischemia-reperfusion injury after hepatectomy: A prospective, randomized, controlled study.
Topics: Dexmedetomidine; Hepatectomy; Humans; Prospective Studies; Reperfusion Injury; Single-Blind Method | 2020 |
Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.
Topics: Acute Kidney Injury; Aged; Animals; Apoptosis; China; Dexmedetomidine; Endoplasmic Reticulum Stress; Female; Humans; Ischemia; Kidney; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2020 |
Protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in horses.
Topics: Animals; Dexmedetomidine; Horse Diseases; Horses; Intestinal Mucosa; Intestine, Small; Jejunum; Reperfusion Injury | 2021 |
Effects of dexmedetomidine on the function of distal organs and oxidative stress after lower limb ischaemia-reperfusion in elderly patients undergoing unilateral knee arthroplasty.
Topics: Aged; Arthroplasty, Replacement, Knee; Dexmedetomidine; Humans; Ischemia; Oxidative Stress; Reperfusion; Reperfusion Injury | 2021 |
Effects of dexmedetomidine on inflammatory mediators after tourniquet-induced ischemia-reperfusion injury: a randomized, double-blinded, controlled study.
Topics: Aged; Anesthesia, General; Dexmedetomidine; Double-Blind Method; Female; Humans; Interleukin-6; Male; Middle Aged; Oxidative Stress; Postoperative Complications; Reperfusion Injury; Tourniquets; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine reduces intestinal and hepatic injury after hepatectomy with inflow occlusion under general anaesthesia: a randomized controlled trial.
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Analgesics, Non-Narcotic; Anesthesia, General; Biomarkers; Dexmedetomidine; Double-Blind Method; Female; Hepatectomy; Humans; Intestinal Diseases; Intestines; Liver; Liver Diseases; Male; Middle Aged; Prospective Studies; Reperfusion Injury | 2014 |
[Effects of dexmedetomidine preconditioning attenuating remote lung injury of lower limb ischemia-reperfusion].
Topics: Dexmedetomidine; Humans; Interleukin-6; Interleukin-8; Lower Extremity; Lung Injury; Reperfusion Injury; Tourniquets; Tumor Necrosis Factor-alpha | 2014 |
Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation.
Topics: Adult; Analgesics, Non-Narcotic; Biopsy; Case-Control Studies; Dexmedetomidine; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Liver Diseases; Liver Function Tests; Liver Transplantation; Living Donors; Male; Middle Aged; Postoperative Complications; Prognosis; Prospective Studies; Protective Agents; Reperfusion Injury; Risk Factors | 2016 |
Dexmedetomidine did not reduce the effects of tourniquet-induced ischemia-reperfusion injury during general anesthesia.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Anesthesia, General; Antioxidants; Dexmedetomidine; Drug Administration Schedule; Female; Humans; Lipid Peroxidation; Lower Extremity; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Reperfusion Injury; Tourniquets | 2013 |
162 other study(ies) available for dexmedetomidine and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Inflammasomes; Ischemia; Liver; Liver Diseases; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirtuins | 2020 |
Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression.
Topics: Apoptosis; Dexmedetomidine; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; Hypoxia; Intestines; Pyroptosis; Reperfusion Injury; Signal Transduction; Sirtuin 1 | 2021 |
Effects of Dexmedetomidine and Oxycodone on Neurocognitive and Inflammatory Response After Tourniquet-Induced Ischemia-Reperfusion Injury.
Topics: Animals; Dexmedetomidine; Mice; NF-kappa B; Oxycodone; Reperfusion Injury; Tourniquets | 2022 |
Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway.
Topics: Animals; Dexmedetomidine; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Reperfusion Injury; Signal Transduction | 2021 |
Intraoperative Low-Dose Dexmedetomidine Administration Associated with Reduced Hepatic Ischemia-Reperfusion Injury in Pediatric Deceased Liver Transplantation: A Retrospective Cohort Study.
Topics: Child; Dexmedetomidine; Humans; Liver; Liver Transplantation; Reperfusion Injury; Retrospective Studies | 2021 |
Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway.
Topics: Animals; Biomarkers; Dexmedetomidine; Disease Models, Animal; Gene Expression Regulation; Liver Diseases; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury; Signal Transduction | 2021 |
Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Dexmedetomidine; Heme Oxygenase-1; Membrane Proteins; Mice; Microglia; Neuroprotective Agents; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Reperfusion Injury; Signal Transduction | 2022 |
Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway.
Topics: Animals; Apoptosis; Dexmedetomidine; Ischemia; Mitochondria; Neuroglia; Protein Kinases; Rats; Reperfusion Injury; Sirtuin 3; Tumor Suppressor Protein p53 | 2021 |
Dexmedetomidine Alleviates Gut-Vascular Barrier Damage and Distant Hepatic Injury Following Intestinal Ischemia/Reperfusion Injury in Mice.
Topics: Analgesics, Non-Narcotic; Animals; Capillary Permeability; Dexmedetomidine; Human Umbilical Vein Endothelial Cells; Humans; Injections, Intraperitoneal; Intestinal Mucosa; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury | 2022 |
[Protective effect of dexmedetomidine on testicular torsion-induced ischemia-reperfusion injury: An experimental study].
Topics: Animals; Dexmedetomidine; Male; Rats; Reperfusion Injury; Spermatic Cord Torsion; Superoxide Dismutase | 2021 |
Dexmedetomidine reduces enteric glial cell injury induced by intestinal ischaemia-reperfusion injury through mitochondrial localization of TERT.
Topics: Animals; Dexmedetomidine; DNA, Mitochondrial; Mitochondrial Permeability Transition Pore; Neuroglia; Rats; Rats, Wistar; Reperfusion Injury; Telomerase | 2022 |
MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF-κB Axis.
Topics: Animals; Apoptosis; Brain Ischemia; Cytokines; Dexmedetomidine; Glucose; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mice; MicroRNAs; NF-kappa B; Oxygen; Reperfusion Injury; rho-Associated Kinases; Up-Regulation | 2022 |
Dexmedetomidine Attenuates Spinal Cord Ischemia-reperfusion Injury in Rabbits by Decreasing Oxidation and Apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Dexmedetomidine; Proto-Oncogene Proteins c-bcl-2; Rabbits; Reperfusion Injury; Spinal Cord Ischemia; Superoxide Dismutase | 2023 |
Dexmedetomidine protects H9C2 rat cardiomyocytes against hypoxia/reoxygenation injury by regulating the long non-coding RNA colon cancer-associated transcript 1/microRNA-8063/Wnt/β-catenin axis.
Topics: Animals; beta Catenin; Colonic Neoplasms; Dexmedetomidine; Hypoxia; MicroRNAs; Myocytes, Cardiac; Rats; Reperfusion Injury; RNA, Long Noncoding | 2022 |
Dexmedetomidine exerts its protective effect on cerebral ischemia reperfusion injury in mice by inhibiting ferroptosis.
Topics: Animals; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Ferroptosis; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Reperfusion Injury | 2022 |
Protective effects of brain-targeted dexmedetomidine nanomicelles on mitochondrial dysfunction in astrocytes of cerebral ischemia/reperfusion injury rats.
Topics: Animals; Apoptosis; Astrocytes; Brain; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Humans; Mitochondria; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Interleukin-6; Janus Kinase 2; Male; Neuroinflammatory Diseases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2022 |
Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia-Reperfusion Injury.
Topics: Animals; Dexmedetomidine; Kidney; Rats; Reperfusion Injury; Spinal Cord Ischemia | 2022 |
Dexmedetomidine Ameliorated Cognitive Dysfunction Induced by Intestinal Ischemia Reperfusion in Mice with Possible Relation to the Anti-inflammatory Effect Through the Locus Coeruleus Norepinephrine System.
Topics: Adrenergic Antagonists; Animals; Anti-Inflammatory Agents; Benzylamines; Cognitive Dysfunction; Dexmedetomidine; Eosine Yellowish-(YS); Hematoxylin; Ischemia; Locus Coeruleus; Malondialdehyde; Mice; Neuroprotective Agents; Neurotoxins; Norepinephrine; Reperfusion; Reperfusion Injury; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Yohimbine | 2022 |
Dexmedetomidine Confers Protection Against Neuronal Oxygen Glucose Deprivation-Reperfusion by Regulating SIRT3 Mediated Autophagy.
Topics: Acridine Orange; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Autophagy-Related Proteins; Dexmedetomidine; Glucose; Humans; Hydrogen Peroxide; Neurons; Oxygen; Reperfusion; Reperfusion Injury; Signal Transduction; Sirtuin 3; TOR Serine-Threonine Kinases | 2022 |
Dexmedetomidine (Dex) exerts protective effects on rat neuronal cells injured by cerebral ischemia/reperfusion via regulating the Sphk1/S1P signaling pathway.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Cerebral Infarction; Dexmedetomidine; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Signal Transduction | 2023 |
Dexmedetomidine treatment prevents cerebral ischemic reperfusion injury through HIF-1α/Beclin1-mediated autophagy.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Brain Ischemia; Dexmedetomidine; Humans; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain Ischemia; Dexmedetomidine; Hippocampus; Infarction, Middle Cerebral Artery; Kelch-Like ECH-Associated Protein 1; Mitophagy; NF-E2-Related Factor 2; Rats; Reperfusion Injury; Signal Transduction | 2022 |
Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.
Topics: Animals; Apoptosis; Dexmedetomidine; Male; Myocardial Reperfusion Injury; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Sirtuin 3; Superoxide Dismutase | 2023 |
Dexmedetomidine attenuates hepatic ischemia-reperfusion injury-induced apoptosis via reducing oxidative stress and endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Dexmedetomidine; Endoplasmic Reticulum Stress; Endoribonucleases; Liver; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Reperfusion Injury | 2023 |
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping.
Topics: Acute Kidney Injury; Animals; Constriction; Dexmedetomidine; Epithelial Cells; Interleukin-6; Kidney; Necrosis; Rats; Reperfusion Injury | 2023 |
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling.
Topics: Animals; Apoptosis; Creatine Kinase, MB Form; Dexmedetomidine; Disease Models, Animal; Hypoxia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Receptors, Adrenergic, alpha; Reperfusion Injury; Signal Transduction | 2023 |
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Ferredoxins; Homeostasis; Rats; Reperfusion; Reperfusion Injury | 2023 |
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K/Akt/mTOR pathway.
Topics: Animals; Autophagy; Beclin-1; Cerebral Infarction; Dexmedetomidine; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; TOR Serine-Threonine Kinases | 2023 |
Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats.
Topics: Animals; Brain Ischemia; Caspase 3; Cerebral Infarction; Dexmedetomidine; Glial Fibrillary Acidic Protein; Humans; Ischemic Stroke; Male; Methionyl Aminopeptidases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis.
Topics: Animals; Apoptosis; Cell Line; Dexmedetomidine; MEF2 Transcription Factors; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-E2-Related Factor 2; Pyroptosis; Rats; Reperfusion Injury | 2023 |
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF-κB.
Topics: Animals; Dexmedetomidine; Infarction; Inflammation; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2023 |
DEXMEDETOMIDINE AMELIORATES ACUTE BRAIN INJURY INDUCED BY MYOCARDIAL ISCHEMIA-REPERFUSION VIA UPREGULATING THE HIF-1 PATHWAY.
Topics: Animals; Brain Injuries; Coronary Artery Disease; Dexmedetomidine; Humans; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2023 |
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Dexmedetomidine; Inflammation; Ischemia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion Injury; Signal Transduction; Sirtuin 3 | 2023 |
Dexmedetomidine Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury in Rats by Suppressing Mitophagy Via Activating Α2-Adrenergic Receptor.
Topics: Animals; Beclin-1; Dexmedetomidine; Mitophagy; Myocardial Infarction; Myocardial Reperfusion Injury; Protein Kinases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Adrenergic; Reperfusion Injury; Ubiquitin-Protein Ligases | 2023 |
Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats.
Topics: Animals; Autophagy; Brain Injuries; Dexmedetomidine; Infarction, Middle Cerebral Artery; Inflammation; JNK Mitogen-Activated Protein Kinases; Learning Disabilities; MAP Kinase Signaling System; Memory Disorders; Rats; Reperfusion Injury | 2019 |
Incomplete clinical evaluation regarding protective effects of dexmedetomidine on stress and inflammatory responses.
Topics: Dexmedetomidine; Humans; Inflammation Mediators; Reperfusion Injury; Tourniquets | 2020 |
[Dexmedetomidine hydrochloride up-regulates expression of hypoxia inducible factor-1α to alleviate renal ischemiareperfusion injury in diabetic rats].
Topics: Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
[Protective effects of dexmedetomidine against pulmonary ischemia-reperfusion injury during cardiopulmonary bypass in rats].
Topics: Animals; Cardiopulmonary Bypass; Dexmedetomidine; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2019 |
Effects of dexmedetomidine on malondialdehyde and proinflammatory cytokines after tourniquet-induced ischemia-reperfusion injury in total knee arthroplasty.
Topics: Arthroplasty, Replacement, Knee; Cytokines; Dexmedetomidine; Humans; Malondialdehyde; Reperfusion Injury; Tourniquets | 2020 |
The role of Wnt/β-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia/reperfusion injury in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; beta Catenin; Dexmedetomidine; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Wnt Proteins | 2019 |
Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia-reperfusion injury by targeting the CNPY2-endoplasmic reticulum stress signalling.
Topics: Animals; Apoptosis; Carrier Proteins; Caspases; Dexmedetomidine; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Spinal Cord; Spinal Cord Ischemia | 2019 |
Dexmedetomidine Protects Against Oxygen-Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway.
Topics: Adenine; Animals; Astrocytes; Autophagy; Cell Hypoxia; Cells, Cultured; Dexmedetomidine; Drug Evaluation, Preclinical; Glucose; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein | 2020 |
Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Brain Injuries; Dexmedetomidine; Drug Evaluation, Preclinical; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Male; Random Allocation; Rats, Sprague-Dawley; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor | 2019 |
Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
Topics: Acute Kidney Injury; Anesthetics; Animals; Cell Adhesion Molecules; Creatinine; Dexmedetomidine; Gene Expression; Kidney Diseases; Male; Rats; Rats, Wistar; Reperfusion Injury; Sirtuin 2; Sirtuins | 2020 |
Protective Effects of Dexmedetomidine and Oxycodone in Patients Undergoing Limb Ischemia-Reperfusion.
Topics: Adult; Aged; Brain-Derived Neurotrophic Factor; China; Dexmedetomidine; Endothelin-1; Fatty Acid Binding Protein 3; Female; Hemodynamics; Humans; Interleukin-6; Ischemia; Lower Extremity; Male; Malondialdehyde; Middle Aged; Oxycodone; Peripheral Vascular Diseases; Prospective Studies; Random Allocation; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway.
Topics: Animals; Brain Ischemia; Dexmedetomidine; HMGB1 Protein; Hydrogen Peroxide; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway.
Topics: Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dexmedetomidine; Down-Regulation; Glucose; Heme Oxygenase-1; Hepatocytes; Humans; Inflammation; Liver; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Reperfusion Injury; Signal Transduction; Up-Regulation | 2019 |
Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion.
Topics: Acute Lung Injury; Animals; Antioxidants; Cytokines; Dexmedetomidine; Disease Models, Animal; Heme Oxygenase-1; Lung; Male; Malondialdehyde; NF-E2 Transcription Factor; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Superoxide Dismutase | 2020 |
Dexmedetomidine protects H9C2 against hypoxia/reoxygenation injury through miR-208b-3p/Med13/Wnt signaling pathway axis.
Topics: Apoptosis; Cell Line; Cell Survival; Dexmedetomidine; Gene Expression Regulation; Genes, Reporter; Humans; Hypoxia; Mediator Complex; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Reperfusion Injury; Wnt Signaling Pathway | 2020 |
Dexmedetomidine protects intestinal ischemia-reperfusion injury via inhibiting p38 MAPK cascades.
Topics: Animals; Apoptosis; Caco-2 Cells; Dexmedetomidine; Glucose; Humans; Inflammation; Intestines; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Oxygen; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats, Wistar; Reperfusion Injury | 2020 |
Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Horses; Ischemia; Ischemic Preconditioning; Jejunum; Random Allocation; Reperfusion Injury | 2020 |
Effects of dexmedetomidine on new oxidative stress markers on renal ischaemia-reperfusion injury in rats: thiol/disulphide homeostasis and the ischaemia-modified albumin.
Topics: Animals; Antioxidants; Biomarkers; Dexmedetomidine; Disulfides; Homeostasis; Kidney; Necrosis; Oxidants; Oxidative Stress; Rats; Reperfusion Injury; Serum Albumin; Serum Albumin, Human; Sulfhydryl Compounds | 2022 |
Protective effects of dexmedetomidine on the survival of random flaps.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents; Antioxidants; Dexmedetomidine; Inflammation Mediators; Lipid Peroxidation; Necrosis; Neovascularization, Physiologic; Oxidative Stress; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Surgical Flaps; Tissue Survival; Vascular Endothelial Growth Factor A | 2020 |
Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cell Line; Dexmedetomidine; Disease Models, Animal; Down-Regulation; Forkhead Box Protein O3; Humans; Male; MicroRNAs; Myocardial Reperfusion Injury; Myocardium; Protective Agents; Pyroptosis; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2020 |
Dexmedetomidine ameliorates renal ischemia reperfusion-mediated activation of the NLRP3 inflammasome in alveolar macrophages.
Topics: Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; Cell Line; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Ischemia; Macrophages, Alveolar; NADPH Oxidase 4; Nitric Oxide Synthase Type III; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger | 2020 |
Dexmedetomidine alleviates non-ventilation associated lung injury via modulating immunology phenotypes of macrophages.
Topics: Aged; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dexmedetomidine; Female; Humans; Lung; Lung Injury; Macrophages; Male; Middle Aged; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
[Role of mitochondrial fusion and fission in protective effects of dexmedetomidine against cerebral ischemia/reperfusion injury in mice].
Topics: Animals; Brain Ischemia; Dexmedetomidine; Male; Mice; Mice, Inbred ICR; Mitochondrial Dynamics; Reperfusion Injury | 2020 |
The outcomes of dexmedetomidine and calcitriol on flap viability.
Topics: Animals; Calcitriol; Dexmedetomidine; Rats; Rats, Wistar; Reperfusion Injury; Surgical Flaps | 2020 |
Dexmedetomidine inhibits microglial activation through SNHG14/HMGB1 pathway in spinal cord ischemia-reperfusion injury mice.
Topics: Animals; Behavior, Animal; Dexmedetomidine; Disease Models, Animal; HMGB1 Protein; Locomotion; Mice; Microglia; Reperfusion Injury; RNA, Long Noncoding; Signal Transduction; Spinal Cord Vascular Diseases | 2022 |
Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43.
Topics: Animals; Astrocytes; Brain Ischemia; Connexin 43; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Male; Perioperative Care; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation | 2020 |
Dexmedetomidine Protects against Myocardial Ischemia/Reperfusion Injury by Ameliorating Oxidative Stress and Cell Apoptosis through the Trx1-Dependent Akt Pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dexmedetomidine; Heart; Humans; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Perfusion; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Thioredoxins | 2020 |
Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Base Pairing; Base Sequence; Caspase 3; Caspase 9; Cell Survival; Dexmedetomidine; Endothelial Cells; Female; Gene Expression Regulation; HEK293 Cells; Humans; Lung; Malondialdehyde; Mice; Mice, Inbred C57BL; MicroRNAs; Nuclear Receptor Subfamily 4, Group A, Member 1; Reperfusion Injury; Signal Transduction | 2020 |
Dexmedetomidine Resists Intestinal Ischemia-Reperfusion Injury by Inhibiting TLR4/MyD88/NF-κB Signaling.
Topics: Animals; Biomarkers; Blotting, Western; Caco-2 Cells; Cell Survival; Dexmedetomidine; Humans; Intestinal Diseases; Intestines; Male; Myeloid Differentiation Factor 88; NF-kappa B; Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism.
Topics: Animals; Dexmedetomidine; Humans; Male; Malondialdehyde; Priapism; Rats; Reperfusion Injury; Superoxide Dismutase | 2021 |
Dexmedetomidine postconditioning alleviates spinal cord ischemia-reperfusion injury in rats via inhibiting neutrophil infiltration, microglia activation, reactive gliosis and CXCL13/CXCR5 axis activation.
Topics: Animals; Caspase 3; Dexmedetomidine; Gliosis; Interleukin-6; Microglia; Neutrophil Infiltration; Rats; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia; Tumor Necrosis Factor-alpha | 2023 |
The effect of dexmedetomidine on gastric ischemia reperfusion injury in rats. Biochemical and histopathological evaluation.
Topics: Animals; Antioxidants; Dexmedetomidine; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury; Stomach; Superoxide Dismutase | 2021 |
Administration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury.
Topics: Animals; Dexmedetomidine; Injections, Intraperitoneal; Male; Protective Agents; Rabbits; Reperfusion Injury; Testis | 2021 |
[Dexmedetomidine alleviates hepatic ischemia-reperfusion injury by regulating MALAT1/miR-126-5p/HMGB1 axis].
Topics: Dexmedetomidine; HMGB1 Protein; Humans; MicroRNAs; Reperfusion Injury; RNA, Long Noncoding | 2021 |
The Protective Mechanism of Dexmedetomidine in Regulating Atg14L-Beclin1-Vps34 Complex Against Myocardial Ischemia-Reperfusion Injury.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Autophagy; Autophagy-Related Proteins; Beclin-1; Chromones; Class III Phosphatidylinositol 3-Kinases; Dexmedetomidine; Disease Models, Animal; Morpholines; Myocytes, Cardiac; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2021 |
The Protective Effects of Dexmedetomidine against Hypoxia/Reoxygenation-Induced Inflammatory Injury and Permeability in Brain Endothelial Cells Mediated by Sigma-1 Receptor.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Dexmedetomidine; Endothelial Cells; Hypoxia; Infarction, Middle Cerebral Artery; Mice; Permeability; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor | 2021 |
Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a.
Topics: Animals; Antigens, Nuclear; Beclin-1; Brain Ischemia; Caspase 3; Cerebral Cortex; Dexmedetomidine; Disease Models, Animal; Infarction, Middle Cerebral Artery; Injections; Male; MicroRNAs; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; RNA-Binding Proteins | 2021 |
Dexmedetomidine Attenuates Myocardial Injury Induced by Renal Ischemia/Reperfusion by Inhibiting the HMGB1-TLR4-MyD88-NF-κB Signaling Pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; HMGB1 Protein; Ischemia; Male; Myeloid Differentiation Factor 88; Myocardial Infarction; NF-kappa B; Rats; Rats, Wistar; Reperfusion Injury; Toll-Like Receptor 4 | 2021 |
Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway.
Topics: Animals; Brain Ischemia; Dexmedetomidine; MAP Kinase Signaling System; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Dexmedetomidine preconditioning ameliorates lung injury induced by pulmonary ischemia/reperfusion by upregulating promoter histone H3K4me3 modification of KGF-2.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cell Membrane Permeability; Dexmedetomidine; Endothelium, Vascular; Fibroblast Growth Factor 10; Histones; Jumonji Domain-Containing Histone Demethylases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Reperfusion Injury; Up-Regulation | 2021 |
Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; MicroRNAs; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; rho-Associated Kinases | 2021 |
Does remifentanil attenuate renal ischemia-reperfusion injury better than dexmedetomidine in rat kidney?
Topics: Analgesics, Opioid; Animals; Dexmedetomidine; Injections, Intravenous; Kidney; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Reperfusion Injury | 2017 |
Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Encephalitis; Hippocampus; Inflammation; Inflammation Mediators; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Effects of dexmedetomidine on renal tissue after lower limb ischemia reperfusion injury in streptozotocin induced diabetic rats.
Topics: Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Kidney; Laparotomy; Lipid Peroxidation; Lower Extremity; Male; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Streptozocin | 2017 |
Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the P38-MAPK/TXNIP signaling activation in streptozotocin induced diabetic rats.
Topics: Animals; Carrier Proteins; Dexmedetomidine; Diabetes Mellitus, Experimental; Kidney; Male; p38 Mitogen-Activated Protein Kinases; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Streptozocin | 2017 |
Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; gamma-Aminobutyric Acid; Glutamine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2017 |
Dexmedetomidine preconditioning protects against retinal ischemia/reperfusion injury and inhibits inflammation response via toll-like receptor 4 (TLR4) pathway.
Topics: Animals; Dexmedetomidine; Hypnotics and Sedatives; Inflammation Mediators; Ischemic Preconditioning; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retina; Retinal Vessels; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Dexmedetomidine preconditioning plays a neuroprotective role and suppresses TLR4/NF-κB pathways model of cerebral ischemia reperfusion.
Topics: Animals; Brain Ischemia; Dexmedetomidine; Infarction, Middle Cerebral Artery; Interferon-beta; Ischemia; Male; Neuroprotection; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2017 |
Protective effects of dexmedetomidine and remote ischemic preconditioning on renal ischemia reperfusion injury in rats.
Topics: Animals; Dexmedetomidine; Ischemic Preconditioning; Kidney; Male; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2017 |
Dexmedetomidine Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Suppressing TLR4-MyD88-NF-
Topics: Animals; Cell Hypoxia; Cell Line; Cells, Cultured; Dexmedetomidine; Gene Knockdown Techniques; Models, Biological; Myeloid Differentiation Factor 88; Myocytes, Cardiac; NF-kappa B; Protective Agents; Rats; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2017 |
The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Dexmedetomidine; Disease Models, Animal; Heat-Shock Proteins; Ischemia; Lung; Male; Malondialdehyde; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reference Values; Reperfusion Injury; Reproducibility of Results; Superoxide Dismutase; Time Factors; Treatment Outcome | 2018 |
Effects of dexmedetomidine post‑treatment on BDNF and VEGF expression following cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Line; Dexmedetomidine; Gene Expression Regulation; Male; Rats; Reperfusion Injury; RNA, Messenger; Vascular Endothelial Growth Factor A | 2018 |
Dexmedetomidine attenuates lung apoptosis induced by renal ischemia-reperfusion injury through α
Topics: Animals; Apoptosis; Blood Gas Analysis; Cell Survival; Dexmedetomidine; Endothelial Cells; Kidney; Lung; Male; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction | 2018 |
Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cellular Senescence; Dexmedetomidine; Fibrosis; Imidazoles; Inflammation; Isoindoles; Kidney; Male; Mice; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction; Sirolimus | 2018 |
Dexmedetomidine protects hepatic cells against oxygen-glucose deprivation/reperfusion injury via lncRNA CCAT1.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dexmedetomidine; Glucose; Hepatocytes; Humans; Hypoxia; Liver; Oxygen; Protective Agents; Reperfusion Injury; RNA, Long Noncoding | 2018 |
[Effect of dexmedetomidine on renal injury induced by lung ischemia/reperfusion in mice].
Topics: Animals; Dexmedetomidine; Imidazoles; Interleukin-1beta; Kidney; Lung Injury; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2017 |
Dexmedetomidine attenuates cerebral ischemia/reperfusion injury in neonatal rats by inhibiting TLR4 signaling.
Topics: Animals; Brain; Brain Ischemia; CA3 Region, Hippocampal; Cerebral Cortex; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Lipopolysaccharides; Neuroprotective Agents; Pilot Projects; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toll-Like Receptor 4 | 2018 |
[Effect of dexmedetomidine on the changes of EAA and the expression of NMDA NR1 protein in hippocampus in global cerebral ischemia/reperfusion rats].
Topics: Animals; Brain Ischemia; Dexmedetomidine; Excitatory Amino Acids; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2016 |
Dexmedetomidine Preconditioning Ameliorates Inflammation and Blood-Spinal Cord Barrier Damage After Spinal Cord Ischemia-Reperfusion Injury by Down-Regulation High Mobility Group Box 1-Toll-Like Receptor 4-Nuclear Factor κB Signaling Pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Down-Regulation; HMGB1 Protein; Inflammation; Male; NF-kappa B; Rabbits; Reperfusion Injury; Signal Transduction; Spinal Cord Ischemia; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine attenuates spinal cord ischemia-reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits.
Topics: Animals; Apoptosis; Blood Pressure; Caspase 3; Dexmedetomidine; Female; Heart Rate; Inflammation; Male; Microglia; Models, Biological; Motor Activity; NF-kappa B; Rabbits; Reperfusion Injury; Signal Transduction; Spinal Cord Ischemia; Toll-Like Receptor 4 | 2018 |
Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK.
Topics: Adenylate Kinase; Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; Enzyme Activation; Infarction, Middle Cerebral Artery; Inflammation; Male; Motor Activity; Neurons; Phosphorylation; Rats, Sprague-Dawley; Reperfusion Injury | 2018 |
Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis; Cytoprotection; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hemodynamics; Kidney; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Streptozocin | 2018 |
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspases; Dexmedetomidine; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotection; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Transcription Factor CHOP | 2018 |
Protective effect of ulinastatin combined with dexmedetomidine on lung injury after cold ischemia-reperfusion in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cold Ischemia; Cytokines; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Glycoproteins; Inflammation Mediators; Lipid Peroxidation; Liver Transplantation; Lung; Male; Malondialdehyde; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2018 |
Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Catecholamines; Dexmedetomidine; Imidazoles; Inflammation Mediators; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Parasympathetic Nervous System; Reperfusion Injury; Vagus Nerve | 2020 |
Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation.
Topics: Acetylation; Animals; Cells, Cultured; Cyclophilins; Dexmedetomidine; Kidney; Male; Mice; Mice, Inbred C57BL; Mitochondria; Peptidyl-Prolyl Isomerase F; Reperfusion Injury; Sirtuin 3 | 2018 |
Intravenous dexmedetomidine: can it modulate the effects of inflammation, or is it only an antinociceptive agent?
Topics: Dexmedetomidine; Humans; Inflammation; Inflammation Mediators; Reperfusion Injury; Tourniquets | 2019 |
Dexmedetomidine alleviates lung ischemia-reperfusion injury in rats by activating PI3K/Akt pathway.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Disease Models, Animal; Humans; Lung; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2019 |
Dexmedetomidine Attenuates Renal and Myocardial Ischemia/Reperfusion Injury in a Dose-Dependent Manner by Inhibiting Inflammatory Response.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Inflammation; Inflammation Mediators; Kidney Diseases; Male; Myocardial Ischemia; Rats; Rats, Wistar; Reperfusion Injury | 2019 |
Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats via Extracellular Signal-Regulated Kinase/Cyclic Adenosine Monophosphate Response Element Binding Protein Signaling Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Dexmedetomidine; Extracellular Signal-Regulated MAP Kinases; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2019 |
Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia/reperfusion injury: An in vivo and in vitro study.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Dexmedetomidine; Diabetes Mellitus, Experimental; Disease Models, Animal; Hyperglycemia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction | 2019 |
The Pathway of Let-7a-1/2-3p and HMGB1 Mediated Dexmedetomidine Inhibiting Microglia Activation in Spinal Cord Ischemia-Reperfusion Injury Mice.
Topics: Analgesics, Non-Narcotic; Animals; Cells, Cultured; Dexmedetomidine; HMGB1 Protein; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Reperfusion Injury; Spinal Cord; Tumor Necrosis Factor-alpha | 2019 |
Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion.
Topics: Alanine Transaminase; Animals; Antibodies, Neutralizing; Aspartate Aminotransferases; Dexmedetomidine; Fibronectins; Intestines; Ischemia; Liver; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2019 |
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Topics: Animals; Apoptosis; Cell Hypoxia; Dexmedetomidine; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mitochondria; Neurons; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Dexmedetomidine protects against lung injury induced by limb ischemia-reperfusion via the TLR4/MyD88/NF-κB pathway.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Dexmedetomidine; Extremities; Lung; Lung Injury; Male; Myeloid Differentiation Factor 88; NF-kappa B; Organ Size; Peroxidase; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Postischemic sevoflurane offers no additional neuroprotective benefit to preischemic dexmedetomidine.
Topics: Actins; Anesthetics, Inhalation; Animals; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Brain; Dexmedetomidine; Hemoglobins; Hypnotics and Sedatives; In Situ Nick-End Labeling; Ischemic Attack, Transient; Ischemic Preconditioning; Methyl Ethers; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sevoflurane; Tissue Embedding | 2013 |
Protective effects of dexmedetomidine in pneumoperitoneum-related ischaemia-reperfusion injury in rat ovarian tissue.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Drug Evaluation, Preclinical; Female; Malondialdehyde; Ovarian Diseases; Ovary; Pneumoperitoneum, Artificial; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
Continuous infusion of dexmedetomidine improves renal ischemia-reperfusion injury in rat kidney.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Dexmedetomidine; Hemodynamics; Infusions, Intravenous; Kidney; Male; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reperfusion Injury | 2013 |
Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation.
Topics: Animals; Apoptosis; Caspase 3; Chemokine CCL2; Dexmedetomidine; Epithelial Cells; Intercellular Adhesion Molecule-1; Janus Kinases; Kidney; Kidney Function Tests; Kidney Tubules; Male; Phosphorylation; Protective Agents; Rats, Wistar; Reperfusion Injury; Signal Transduction; STAT Transcription Factors | 2013 |
Dexmedetomidine protects against ischemia-reperfusion injury in rat skeletal muscle.
Topics: Animals; Catalase; Dexmedetomidine; Glutathione; Interleukin-1beta; Malondialdehyde; Muscle, Skeletal; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2014 |
Discussion.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Male; Neuroprotective Agents; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia | 2014 |
Dexmedetomidine, an α-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Aorta, Thoracic; Brain-Derived Neurotrophic Factor; Constriction; CREB-Binding Protein; Dexmedetomidine; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction; Spinal Cord; Spinal Cord Ischemia; Time Factors | 2014 |
Effect of dexmedetomidine on lung ischemia‑reperfusion injury.
Topics: Animals; Bronchoalveolar Lavage; Dexmedetomidine; Interleukin-6; Lung; Lung Injury; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2014 |
The effect of dexmedetomidine on oxidative stress during pneumoperitoneum.
Topics: Animals; Antioxidants; Dexmedetomidine; Female; Oxidative Stress; Pneumoperitoneum; Protective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
The protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Male; Rats; Rats, Wistar; Reperfusion Injury; Retina; Retinal Diseases | 2014 |
Dexmedetomidine protects against ischemia/reperfusion injury in rat kidney.
Topics: Acute-Phase Proteins; Animals; Apoptosis; Biomarkers; Blood Urea Nitrogen; Creatine; Cystatin C; Dexmedetomidine; Janus Kinase 2; Kidney Diseases; Kidney Tubules; Lipocalin-2; Lipocalins; Male; Necrosis; Protective Agents; Proto-Oncogene Proteins; Rats, Wistar; Reperfusion Injury; STAT3 Transcription Factor | 2014 |
Effects of dexmedetomidine on microregional O2 balance during reperfusion after focal cerebral ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Hemodynamics; Infarction, Middle Cerebral Artery; Male; Oxygen Consumption; Pons; Rats; Rats, Inbred F344; Reperfusion Injury | 2015 |
The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury.
Topics: Animals; Dexmedetomidine; Ischemia; Ischemic Preconditioning; Liver; Liver Diseases; Protective Agents; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury | 2014 |
Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor.
Topics: Animals; Astrocytes; Cell Culture Techniques; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Mice; Mice, Inbred C57BL; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia | 2015 |
Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Forelimb; Functional Laterality; G-Protein-Coupled Receptor Kinase 2; Gene Expression Regulation; Hyperalgesia; Hypnotics and Sedatives; Ischemia; Neurons; Pain Threshold; Rats; Reperfusion Injury; Statistics, Nonparametric; Superior Cervical Ganglion; Time Factors | 2015 |
Acute hyperglycemia prevents dexmedetomidine-induced preconditioning against renal ischemia-reperfusion injury.
Topics: Acute Disease; Animals; Apoptosis; Blood Glucose; Creatinine; Dexmedetomidine; Hyperglycemia; Ischemia; Ischemic Preconditioning; Kidney; Kidney Tubules; Male; Models, Animal; Nephrectomy; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Urea | 2014 |
Dexmedetomidine protects against apoptosis induced by hypoxia/reoxygenation through the inhibition of gap junctions in NRK-52E cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Blotting, Western; Cell Communication; Cell Proliferation; Cells, Cultured; Dexmedetomidine; Flow Cytometry; Gap Junctions; HeLa Cells; Humans; Hypoxia; Kidney Tubules; Male; Oxygen; Protective Agents; Rats; Reperfusion Injury; Signal Transduction | 2015 |
Dexmedetomidine on renal ischemia-reperfusion injury in rats: assessment by means of NGAL and histology.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Kidney Tubules; Lipocalin-2; Lipocalins; Protective Agents; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Treatment Outcome | 2015 |
Alpha-2 agonist attenuates ischemic injury in spinal cord neurons.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Cardiovascular Surgical Procedures; Cell Survival; Cells, Cultured; Cytokines; Dexmedetomidine; Drug Evaluation, Preclinical; Glucose; Hypoxia; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Spinal Cord; Spinal Cord Injuries | 2015 |
The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Kidney; Kidney Tubules; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
Dexmedetomidine attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia reperfusion injury in rats.
Topics: Angiopoietin-1; Animals; Capillary Permeability; Dexmedetomidine; Disease Models, Animal; Injections, Spinal; Ischemic Preconditioning; Male; Matrix Metalloproteinase 9; Rats; Receptor, TIE-2; Reperfusion Injury; Spinal Cord; Spinal Cord Ischemia | 2015 |
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antioxidants; Dexmedetomidine; Immunohistochemistry; Ischemia; Male; Oxidative Stress; Prospective Studies; Random Allocation; Rats, Wistar; Reference Values; Reperfusion Injury; Severity of Illness Index; Spermatic Cord Torsion; Testis; Time Factors | 2015 |
Protective effects of udenafil citrate, piracetam and dexmedetomidine treatment on testicular torsion/detorsion-induced ischaemia/reperfusion injury in rats.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Male; Piracetam; Protective Agents; Pyrimidines; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Sulfonamides; Treatment Outcome | 2016 |
[The effect of dexmedetomidine on autophagy and apoptosis in intestinal ischemia reperfusion-induced lung injury].
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Dexmedetomidine; Lung; Lung Injury; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2015 |
Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia/reperfusion injury in rats.
Topics: Actins; Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Blood Urea Nitrogen; Blotting, Western; Creatinine; Dexmedetomidine; HMGB1 Protein; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Kidney; Male; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats.
Topics: Animals; Brain Ischemia; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Hemodynamics; Inflammation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model.
Topics: Acute Kidney Injury; Animals; Antioxidants; Curcumin; Dexmedetomidine; Disease Models, Animal; Extremities; Kidney; Kidney Function Tests; Oxidative Stress; Rats; Reperfusion Injury; Treatment Outcome | 2016 |
[Effects of dexmedetomidine on microcirculatory perfusion in rabbits with renal ischemia/reperfusion injury: quantitative evaluation with contrast-enhanced ultrasound].
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Kidney; Kidney Diseases; Microcirculation; Rabbits; Renal Artery; Reperfusion Injury | 2016 |
Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Dexmedetomidine; Interleukin-1beta; Liver; Male; NF-kappa B; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Toll-Like Receptor 4 | 2016 |
Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway.
Topics: Animals; Chromones; Dexmedetomidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypnotics and Sedatives; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Lung Injury; Male; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2016 |
α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury.
Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Endothelium; Focal Adhesion Kinase 1; Humans; Imidazoles; Kidney; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction | 2016 |
The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Topics: Animals; Apoptosis; Brain Diseases; Calcium; Dexmedetomidine; Ganglia, Spinal; Hippocampus; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; TRPM Cation Channels; TRPV Cation Channels | 2016 |
Protection of Dexmedetomidine Against Ischemia/Reperfusion-Induced Apoptotic Insults to Neuronal Cells Occurs Via an Intrinsic Mitochondria-Dependent Pathway.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Dexmedetomidine; DNA Fragmentation; Humans; Mitochondria; Mitochondrial Proteins; Neurons; Reperfusion Injury | 2017 |
The Effect of Dexmedetomidine on Oxidative Stress Response Following Cerebral Ischemia-Reperfusion in Rats and the Expression of Intracellular Adhesion Molecule-1 (ICAM-1) and S100B.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; Superoxide Dismutase | 2017 |
Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: a histopathologic study.
Topics: Acute Kidney Injury; Adrenergic alpha-Agonists; Animals; Dexmedetomidine; Kidney Glomerulus; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2009 |
Dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic brain injury in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Hypnotics and Sedatives; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Resistance; Yohimbine | 2009 |
Effect of dexmedetomidine on testicular torsion/detorsion damage in rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptotic Protease-Activating Factor 1; Dexmedetomidine; Germ Cells; Ischemia; Male; Malondialdehyde; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Testis | 2010 |
Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics; Animals; Creatinine; Dexmedetomidine; Ketamine; Kidney; Male; Rats; Rats, Wistar; Reperfusion Injury | 2011 |
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.
Topics: Acute Kidney Injury; Animals; Cell Line; Dexmedetomidine; Humans; Male; Mice; Mice, Inbred C57BL; Protective Agents; Reperfusion Injury | 2011 |
Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Depression, Chemical; Dexmedetomidine; Imidazoles; Immunohistochemistry; Intercellular Adhesion Molecule-1; Kidney Diseases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Organ Size; Paraffin Embedding; Peroxidase; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2011 |
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart.
Topics: Animals; Dexmedetomidine; Male; Myocardial Ischemia; Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats.
Topics: Adrenergic alpha-Agonists; Amine Oxidase (Copper-Containing); Animals; Apoptosis; Blood Gas Analysis; Caspase 3; Dexmedetomidine; Dose-Response Relationship, Drug; Hemodynamics; Intestinal Mucosa; Intestines; Lactic Acid; Male; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Survival Analysis; Tumor Necrosis Factor-alpha | 2012 |
The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Animals; Antioxidants; Arterial Occlusive Diseases; Dexmedetomidine; Disease Models, Animal; Intestinal Mucosa; Intestines; Kidney; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Arteries; Oxidants; Peroxidase; Rabbits; Reperfusion Injury; Treatment Outcome | 2012 |
Attenuation of spinal cord ischemia-reperfusion injury by specific α-2a receptor activation with dexmedetomidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; Spinal Cord Ischemia | 2012 |
Preventive effect of dexmedetomidine in ischemia-reperfusion injury.
Topics: Analysis of Variance; Animals; Dexmedetomidine; Malondialdehyde; Nitric Oxide; Peroxidase; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Statistics, Nonparametric; Surgical Flaps | 2012 |
Effect of dexmedetomidine on erythrocyte deformability during ischemia-reperfusion injury of liver in diabetic rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Erythrocyte Deformability; Hypnotics and Sedatives; Liver; Male; Rats; Rats, Wistar; Reperfusion Injury | 2012 |
Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Cerebral Cortex; Dexmedetomidine; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2013 |
An investigation about the inhibition of acute ischemia/reperfusion damage by dexmedetomidine in rat ovarian tissue.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Biomarkers; Dexmedetomidine; DNA Damage; Female; Glutathione; Guanine; Ischemia; Lipid Peroxidation; Malondialdehyde; Ovary; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Yohimbine | 2013 |
The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats.
Topics: Animals; Aryldialkylphosphatase; Dexmedetomidine; Histocytochemistry; Kidney; Liver; Lung; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Statistics, Nonparametric | 2013 |
The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Drug Evaluation, Preclinical; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Apoptosis; Blood Gas Analysis; Blotting, Western; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Fluorescent Antibody Technique; Gene Expression Regulation; Hemodynamics; Ketamine; Male; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2003 |
Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain; Dexmedetomidine; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2001 |