Page last updated: 2024-08-24

dexmedetomidine and Drug Withdrawal Symptoms

dexmedetomidine has been researched along with Drug Withdrawal Symptoms in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (17.65)29.6817
2010's37 (54.41)24.3611
2020's19 (27.94)2.80

Authors

AuthorsStudies
Amigoni, A; Azzolina, D; Caramelli, F; Conti, G; Daverio, M; Gregori, D; Lazzarini, R; Mondardini, MC; Muscheri, L; Sperotto, F; Zaggia, C1
Giangregorio, M; Greco, C; Homoki, A; Kleinman, ME; Li, L; Mahoney, J; Mansfield, L; Manzi, SF; Solodiuk, JC; Sweet, E1
Azmaiparashvili, Z; Catahay, JA; Cruz, NS; Danganan, LML; Lo, KB; Macapagal, SC; Patarroyo-Aponte, G; Polintan, ETT1
Baumgartner, K; Doering And, M; Mullins, ME1
Chambers, A; Cumpston, KL; Jenkins, Z; Kershner, E; Tobarran, N; Wills, BK1
Comer, SD; De Vivo, M; Jones, JD; Levin, FR; Rajachandran, L; Risinger, R; Sabados, J; Yocca, F1
DeGrado, JR; Goodberlet, MZ; Lupi, KE; Marino, KK; Schuler, BR; Ware, LR1
Behal, M; Bissell, B; Mefford, B; Pandya, K; Robbins, B; Wiegand, A1
Love, K; Zimmermann, AE1
Amigoni, A; Caligiuri, MF; Caramelli, F; Cecini, MT; Conti, G; Daverio, M; Gregori, D; Mancino, A; Mondardini, MC; Pettenazzo, A; Piastra, M; Sperotto, F; Vitale, F1
Ahmed, S; Brewer, T; Defayette, A; Perrello, A; Picano, J1
Attridge, RL; Christina Gutierrez, G; Glaess, SS1
Grgurich, P; Lei, Y; Nault, K; Salah, J1
Burke, H; Jiang, S; Petriceks, AH; Stern, TA1
Adamczyk, K; Chiu, SH; Kaplan, JB; Pathan, S; Shah, CV1
Collier, TE; Farrell, LB; Kataria, VK; Killian, AD1
Ferguson, L; Hooper, S1
Briceño-Santana, M; Campos-Durán, R; García-Méndez, N; Manterola, C; Otzen, T; Reyna, GC; Totomoch-Serra, A; Valdez, PS1
Geven, BM; Maaskant, JM; van Woensel, JBM; Ward, CS1
Jung, S; Rosini, JM1
Estalella-Mendoza, A; Flores-González, JC; Hernández-González, A; Lechuga-Sancho, AM; Rodríguez-Campoy, P; Rubio-Quiñones, F; Saldaña-Valderas, M1
Al Anany, R; Elshafei, M; Gazwi, K; Mahmoud, S; Mohamed, A; Saad, MO1
Amigoni, A; Brugnaro, L; Campagnano, E; Daverio, M; Dusio, MP; Ferrario, S; Ferrero, F; Mondardini, MC; Rossetti, E; Savron, F; Sperotto, F; Vasile, B; Vitale, F1
Banasch, HL; Dersch-Mills, DA; Howlett, A; Yusuf, K1
Hardman, MI; Sprung, J; Weingarten, TN1
Laroche, JP1
Dagenais, M; Di Genova, T; Fontela, P; Kongkiattikul, L; Ruo, N; Zavalkoff, S1
Brudney, S; Gagliardi, JP; Kerns, S; Muzyk, AJ1
Fish, DN; Kiser, TH; Lavelle, JC; MacLaren, R; Malkoski, SP; Mueller, SW; Preslaski, CR1
Bauer, PR; Dierkhising, RA; Frazee, EN; Leung, JG; Nelson, S; Personett, HA1
Kupfer, Y; Savel, RH1
Balcells, J; Gran, F; Ortega, J; Pujol, M; Sanchez-de-Toledo, J; Vega, L1
Brown, CV; Crispo, AL; Daley, MJ; Harford, PH; Pepin, JL1
Di Gennaro, JL; Irby, GA; Whalen, LD; Yanay, O; Zimmerman, JJ1
Albertson, TE; Chenoweth, J; Ford, J; Owen, K; Sutter, ME1
Fish, DN; Foster, CJ; Kiser, TH; MacLaren, R; Mueller, SW; VanderWeide, LA1
Heard, CM; Li, V; Morr, S; Reynolds, RM1
MacLaren, R; Mueller, SW; Reynolds, PM1
Kane-Gill, SL; Smithburger, PL; Wong, A1
Linn, DD; Loeser, KC1
Cunningham, DW; Davidson, KE; Ferreira, JA; Weisberg, SF; Wieruszewski, PM1
Adjepong, YA; Lukens, C; Manthous, CA; Musial, B; Perez, R; Stewart, R1
Cadiz, M; Doshi, MR; Holzhausen, JM; Natavio, A; Schmidt, KJ; Winegardner, JE1
Eguchi, T; Kawano, Y; Ninomiya, Y; Nomura, Y; Takahashi, Y; Ueno, K1
Hayes, BD; Nelson, LS1
Beg, M; Fisher, S; Liu, VX; Rajan, S; Siu, D; Troxell, L1
Bulloch, MN; Burry, L; Chan, C; Devabhakthuni, S; Dixit, D; Endicott, J; Ramos, L; Tobia, A; Yeung, SY1
Day, RO; Graham, RI; Tay, EM1
Benowitz, NL; Horng, H; Smollin, CG; Vo, KT1
Amusina, O; Leikin, JB1
Gupta, A; Lee, D; Su, M1
Benefield, RJ; Honey, BL; Johnson, PN; Miller, JL1
Darnell, C; Sheeran, P; Steiner, J; Szmuk, P1
Tobias, JD1
Chilipko, A; Fowler, JA; Muzyk, AJ; Norwood, DK1
Kuhn, RJ; McCabe, T; Oschman, A1
Muzyk, AJ; Revollo, JY; Rivelli, SK1
Coker, S; Kukoyi, A; Lewis, L; Nierenberg, D1
Clark, JD; Davies, MF; Haimor, F; Lighthall, G1
Maccioli, GA1
Multz, AS1
Berkenbosch, JW; Russo, P; Tobias, JD1
Elrefai, A; Finkel, JC1
Leung, S; Zapantis, A1
Finkel, JC; Johnson, YJ; Quezado, ZM1
Rosen, DA1
Argalious, M; Bourdakos, D; Chahlavi, A; Ebrahim, Z; Farag, E; Hill, R; Woo, H1
Rosen, DA; Thammasitboon, S; Weber, MD1

Reviews

17 review(s) available for dexmedetomidine and Drug Withdrawal Symptoms

ArticleYear
Adjunctive Dexmedetomidine in Alcohol Withdrawal Syndrome: A Systematic Review and Meta-analysis of Retrospective Cohort Studies and Randomized Controlled Trials.
    The Annals of pharmacotherapy, 2023, Volume: 57, Issue:6

    Topics: Benzodiazepines; Cohort Studies; Dexmedetomidine; Humans; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome

2023
Dexmedetomidine in the treatment of toxicologic conditions: a systematic review and review of the toxicology investigators consortium database.
    Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:12

    Topics: Alcoholism; Analgesics, Opioid; Dexmedetomidine; Humans; Hypnotics and Sedatives; Muscarinic Antagonists; Narcotics; Serotonin Syndrome; Substance Withdrawal Syndrome

2022
Niche Roles for Dexmedetomidine in the Intensive Care Unit.
    The Annals of pharmacotherapy, 2023, Volume: 57, Issue:10

    Topics: Alcoholism; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Substance Withdrawal Syndrome

2023
Clonidine as a strategy for discontinuing dexmedetomidine sedation in critically ill patients: A narrative review.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2020, Mar-24, Volume: 77, Issue:7

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Critical Illness; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Substitution; Humans; Hypnotics and Sedatives; Risk Factors; Substance Withdrawal Syndrome

2020
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
    Bosnian journal of basic medical sciences, 2019, May-20, Volume: 19, Issue:2

    Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Haloperidol; Humans; Lorazepam; Male; Melatonin; Neuroleptic Malignant Syndrome; Olanzapine; Receptors, GABA; Substance Withdrawal Syndrome; Substance-Related Disorders; Young Adult

2019
Dexmedetomidine for the treatment of alcohol withdrawal syndrome: rationale and current status of research.
    CNS drugs, 2013, Volume: 27, Issue:11

    Topics: Adrenergic alpha-2 Receptor Agonists; Biomedical Research; Critical Care; Dexmedetomidine; Ethanol; Humans; Intensive Care Units; Substance Withdrawal Syndrome

2013
Is it prime time for alpha2-adrenocepter agonists in the treatment of withdrawal syndromes?
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2014, Volume: 10, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Alcoholism; Clonidine; Dexmedetomidine; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome; Tobacco Use Disorder

2014
Review of adjunctive dexmedetomidine in the management of severe acute alcohol withdrawal syndrome.
    The American journal of drug and alcohol abuse, 2015, Volume: 41, Issue:5

    Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Benzodiazepines; Dexmedetomidine; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Substance Withdrawal Syndrome

2015
Dexmedetomidine for Alcohol Withdrawal Syndrome.
    The Annals of pharmacotherapy, 2015, Volume: 49, Issue:12

    Topics: Alcohol Withdrawal Delirium; Dexmedetomidine; Ethanol; Humans; Hypertension; Hypnotics and Sedatives; Intensive Care Units; Respiration, Artificial; Substance Withdrawal Syndrome; Tachycardia

2015
Approach to the Complicated Alcohol Withdrawal Patient.
    Journal of intensive care medicine, 2017, Volume: 32, Issue:1

    Topics: Benzodiazepines; Critical Care; Dexmedetomidine; Drug Therapy, Combination; Ethanol; GABA-A Receptor Agonists; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Practice Guidelines as Topic; Severity of Illness Index; Substance Withdrawal Syndrome

2017
Treatment of Severe Alcohol Withdrawal.
    The Annals of pharmacotherapy, 2016, Volume: 50, Issue:5

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Critical Care; Dexmedetomidine; Drug Therapy, Combination; Humans; Phenobarbital; Propofol; Randomized Controlled Trials as Topic; Respiration, Artificial; Retrospective Studies; Substance Withdrawal Syndrome

2016
Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.
    Pharmacotherapy, 2016, Volume: 36, Issue:7

    Topics: Baclofen; Benzodiazepines; Critical Illness; Dexmedetomidine; Ethanol; Humans; Length of Stay; Phenobarbital; Substance Withdrawal Syndrome

2016
Alpha2-receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Child; Clonidine; Critical Illness; Dexmedetomidine; Drug Tolerance; Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome

2009
Role of α2-agonists in the treatment of acute alcohol withdrawal.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Dexmedetomidine; Ethanol; Humans; Norepinephrine; Substance Withdrawal Syndrome

2011
Dexmedetomidine for opioid and benzodiazepine withdrawal in pediatric patients.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2011, Jul-01, Volume: 68, Issue:13

    Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Benzodiazepines; Child; Dexmedetomidine; Drug Administration Schedule; Humans; Retrospective Studies; Substance Withdrawal Syndrome

2011
Additional experience with dexmedetomidine in pediatric patients.
    Southern medical journal, 2003, Volume: 96, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units, Pediatric; Male; Psychomotor Agitation; Shivering; Substance Withdrawal Syndrome

2003
Tolerance and withdrawal issues with sedation.
    Critical care nursing clinics of North America, 2005, Volume: 17, Issue:3

    Topics: Analgesics; Benzodiazepines; Biological Availability; Conscious Sedation; Critical Care; Dexmedetomidine; Drug Administration Schedule; Drug Tolerance; Humans; Hypnotics and Sedatives; Metabolic Clearance Rate; Propofol; Substance Withdrawal Syndrome

2005

Trials

6 trial(s) available for dexmedetomidine and Drug Withdrawal Symptoms

ArticleYear
Dexmedetomidine for prevention of opioid/benzodiazepine withdrawal syndrome in pediatric intensive care unit: Interim analysis of a randomized controlled trial.
    Pharmacotherapy, 2022, Volume: 42, Issue:2

    Topics: Analgesics, Opioid; Benzodiazepines; Child; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units, Pediatric; Substance Withdrawal Syndrome

2022
Sublingual dexmedetomidine (BXCL501) reduces opioid withdrawal symptoms: findings from a multi-site, phase 1b/2, randomized, double-blind, placebo-controlled trial.
    The American journal of drug and alcohol abuse, 2023, 01-02, Volume: 49, Issue:1

    Topics: Analgesics, Opioid; Animals; Cattle; Dexmedetomidine; Double-Blind Method; Female; Humans; Male; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome

2023
Efficacy and safety of dexmedetomidine for prevention of withdrawal syndrome in the pediatric intensive care unit: protocol for an adaptive, multicenter, randomized, double-blind, placebo-controlled, non-profit clinical trial.
    Trials, 2019, Dec-11, Volume: 20, Issue:1

    Topics: Adaptive Clinical Trials as Topic; Adolescent; Adrenergic alpha-2 Receptor Agonists; Age Factors; Analgesics, Opioid; Benzodiazepines; Child; Child, Preschool; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care Units, Pediatric; Italy; Male; Multicenter Studies as Topic; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome

2019
The hemodynamic effects of diazepam versus dexmedetomidine in the treatment of alcohol withdrawal syndrome: A randomized clinical trial.
    Medicina clinica, 2021, 12-24, Volume: 157, Issue:12

    Topics: Alcoholism; Dexmedetomidine; Diazepam; Hemodynamics; Humans; Hypnotics and Sedatives; Intensive Care Units; Prospective Studies; Substance Withdrawal Syndrome

2021
A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal.
    Critical care medicine, 2014, Volume: 42, Issue:5

    Topics: Adult; Anticonvulsants; Dexmedetomidine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Ethanol; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Lorazepam; Middle Aged; Prospective Studies; Statistics, Nonparametric; Substance Withdrawal Syndrome

2014
A comparison of dexmedetomidine and placebo on the plasma concentrations of NGF, BDNF, GDNF, and epinephrine during severe alcohol withdrawal.
    Alcohol (Fayetteville, N.Y.), 2015, Volume: 49, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Alcoholism; Biomarkers; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Double-Blind Method; Epinephrine; Female; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Nerve Growth Factor; Placebo Effect; Severity of Illness Index; Substance Withdrawal Syndrome

2015

Other Studies

45 other study(ies) available for dexmedetomidine and Drug Withdrawal Symptoms

ArticleYear
Weaning Dexmedetomidine in Non-ICU Areas: An Implementation Effort.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2022, 05-01, Volume: 23, Issue:5

    Topics: Child; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Retrospective Studies; Substance Withdrawal Syndrome; Weaning

2022
Clinical characteristics and outcomes using dexmedetomidine in nonintubated patients: A poison center observational study.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2023, 04-08, Volume: 80, Issue:8

    Topics: Dexmedetomidine; Drug-Related Side Effects and Adverse Reactions; Humans; Hypnotics and Sedatives; Poisons; Retrospective Studies; Substance Withdrawal Syndrome

2023
Evaluation of Dexmedetomidine as an Adjunct to Phenobarbital for Alcohol Withdrawal in Critically Ill Patients.
    Journal of intensive care medicine, 2023, Volume: 38, Issue:6

    Topics: Adult; Alcoholism; Benzodiazepines; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Phenobarbital; Retrospective Studies; Substance Withdrawal Syndrome

2023
Use of Propofol Plus Dexmedetomidine in Patients Experiencing Severe Alcohol Withdrawal in the Intensive Care Unit.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:4

    Topics: Alcoholism; Bradycardia; Critical Care; Dexmedetomidine; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units; Length of Stay; Male; Middle Aged; Propofol; Retrospective Studies; Substance Withdrawal Syndrome

2020
Enteral baclofen withdrawal managed with intravenous dexmedetomidine: A case report.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2020, Feb-19, Volume: 77, Issue:5

    Topics: Back Pain; Baclofen; Chronic Pain; Dexmedetomidine; Dose-Response Relationship, Drug; GABA-B Receptor Agonists; Humans; Hypnotics and Sedatives; Male; Middle Aged; Substance Withdrawal Syndrome

2020
Identification of risk factors for hypertension and tachycardia upon dexmedetomidine discontinuation.
    Journal of critical care, 2020, Volume: 59

    Topics: Aged; Case-Control Studies; Critical Illness; Dexmedetomidine; Female; Humans; Hypertension; Hypnotics and Sedatives; Male; Middle Aged; Retrospective Studies; Risk Factors; Substance Withdrawal Syndrome; Tachycardia

2020
Weaning From Exogenous Sedation in the Era of COVID-19 Infection: Recommendations for Sedation and Its Discontinuation.
    The primary care companion for CNS disorders, 2020, Jul-16, Volume: 22, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Betacoronavirus; Coronavirus Infections; COVID-19; Deprescriptions; Dexmedetomidine; Emergence Delirium; Humans; Hypnotics and Sedatives; Male; Neurologic Examination; Pandemics; Pneumonia, Viral; Practice Guidelines as Topic; Propofol; Respiration, Artificial; SARS-CoV-2; Substance Withdrawal Syndrome

2020
Evaluation of dexmedetomidine withdrawal in critically ill adults.
    Journal of critical care, 2021, Volume: 62

    Topics: Adult; Child; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Retrospective Studies; Substance Withdrawal Syndrome

2021
Effect of Adjunctive Dexmedetomidine in the Treatment of Alcohol Withdrawal Compared to Benzodiazepine Symptom-Triggered Therapy in Critically Ill Patients: The EvADE Study.
    Journal of pharmacy practice, 2022, Volume: 35, Issue:3

    Topics: Alcoholism; Benzodiazepines; Cohort Studies; Critical Illness; Dexmedetomidine; Ethanol; Humans; Retrospective Studies; Seizures; Substance Withdrawal Syndrome

2022
Dexmedetomidine withdrawal syndrome and opioid sensitivity.
    BMJ supportive & palliative care, 2023, Volume: 13, Issue:e1

    Topics: Analgesics, Opioid; Dexmedetomidine; Humans; Neoplasms; Pain Management; Substance Withdrawal Syndrome

2023
Dexmedetomidine and Iatrogenic Withdrawal Syndrome in Critically Ill Children.
    Critical care nurse, 2021, Feb-01, Volume: 41, Issue:1

    Topics: Child; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Substance Withdrawal Syndrome

2021
Dexmedetomidine for Treatment of Refractory Heroin Withdrawal.
    Journal of emergency nursing, 2017, Volume: 43, Issue:2

    Topics: Adult; Dexmedetomidine; Female; Heroin Dependence; Humans; Hypnotics and Sedatives; Substance Withdrawal Syndrome

2017
Supraventricular tachycardia after withdrawal of prolonged dexmedetomidine infusion in a paediatric patient without heart disease.
    Journal of clinical pharmacy and therapeutics, 2017, Volume: 42, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Child, Preschool; Dexmedetomidine; Female; Humans; Influenza A Virus, H1N1 Subtype; Intensive Care Units, Pediatric; Respiratory Distress Syndrome; Substance Withdrawal Syndrome; Tachycardia, Paroxysmal; Tachycardia, Supraventricular

2017
Effectivness of Clonidine in Treating Dexmedetomidine Withdrawal in a Patient with Co-Existing Psychiatric Illness: A Case Report.
    The American journal of case reports, 2018, Jul-26, Volume: 19

    Topics: Adult; Central Nervous System Agents; Clonidine; Depressive Disorder, Major; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Meningitis, Viral; Substance Withdrawal Syndrome

2018
Prolonged sedation in critically ill children: is dexmedetomidine a safe option for younger age? An off-label experience.
    Minerva anestesiologica, 2019, Volume: 85, Issue:2

    Topics: Child, Preschool; Critical Illness; Deep Sedation; Delirium; Dexmedetomidine; Drug Interactions; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Male; Off-Label Use; Retrospective Studies; Substance Withdrawal Syndrome

2019
Dexmedetomidine Use in a Tertiary Care NICU: A Descriptive Study.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:5

    Topics: Alberta; British Columbia; Critical Illness; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gestational Age; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Intensive Care Units, Neonatal; Male; Retrospective Studies; Substance Withdrawal Syndrome; Tertiary Healthcare

2019
Subcutaneous dexmedetomidine for baclofen withdrawal during palliative sedation.
    BMJ supportive & palliative care, 2020, Volume: 10, Issue:1

    Topics: Baclofen; Dexmedetomidine; Humans; Hypnotics and Sedatives; Infusions, Subcutaneous; Male; Middle Aged; Palliative Care; Substance Withdrawal Syndrome

2020
The impact of a quality improvement project to standardize pain, agitation, and withdrawal assessments on the use of morphine and midazolam in the Pediatric Intensive Care Unit.
    Paediatric anaesthesia, 2019, Volume: 29, Issue:4

    Topics: Analgesics, Opioid; Compliance; Conscious Sedation; Critical Care; Dexmedetomidine; Humans; Hypnotics and Sedatives; Iatrogenic Disease; Infant; Intensive Care Units; Length of Stay; Midazolam; Morphine; Pain Measurement; Quality Improvement; Substance Withdrawal Syndrome

2019
Influence of dexmedetomidine therapy on the management of severe alcohol withdrawal syndrome in critically ill patients.
    Journal of critical care, 2014, Volume: 29, Issue:2

    Topics: Adult; Benzodiazepines; Blood Pressure; Critical Illness; Dexmedetomidine; Ethanol; Female; Heart Rate; Hemodynamics; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units; Male; Middle Aged; Retrospective Studies; Substance Withdrawal Syndrome

2014
Using dexmedetomidine as adjunctive therapy for patients with severe alcohol withdrawal syndrome: another piece of the puzzle.
    Critical care medicine, 2014, Volume: 42, Issue:5

    Topics: Anticonvulsants; Dexmedetomidine; Ethanol; Humans; Hypnotics and Sedatives; Lorazepam; Substance Withdrawal Syndrome

2014
Prevention of opioid withdrawal syndrome after pediatric heart transplantation: usefulness of dexmedetomidine.
    Revista espanola de cardiologia (English ed.), 2013, Volume: 66, Issue:7

    Topics: Analgesics, Opioid; Child, Preschool; Dexmedetomidine; Heart Transplantation; Humans; Hypnotics and Sedatives; Infant; Male; Substance Withdrawal Syndrome

2013
Comparison of clinical outcomes in nonintubated patients with severe alcohol withdrawal syndrome treated with continuous-infusion sedatives: dexmedetomidine versus benzodiazepines.
    Pharmacotherapy, 2014, Volume: 34, Issue:9

    Topics: Adult; Aged; Benzodiazepines; Cohort Studies; Dexmedetomidine; Ethanol; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Midazolam; Middle Aged; Retrospective Studies; Severity of Illness Index; Substance Withdrawal Syndrome; Treatment Outcome

2014
Long-term dexmedetomidine use and safety profile among critically ill children and neonates.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014, Volume: 15, Issue:8

    Topics: Adolescent; Analgesics, Opioid; Benzodiazepines; Blood Pressure; Child; Child, Preschool; Critical Illness; Dexmedetomidine; Female; Heart Rate; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Male; Retrospective Studies; Substance Withdrawal Syndrome; Time Factors

2014
Evaluation of Early Dexmedetomidine Addition to the Standard of Care for Severe Alcohol Withdrawal in the ICU: A Retrospective Controlled Cohort Study.
    Journal of intensive care medicine, 2016, Volume: 31, Issue:3

    Topics: Adult; Aged; Benzodiazepines; Bradycardia; Case-Control Studies; Chemotherapy, Adjuvant; Colorado; Critical Care; Dexmedetomidine; Drug Administration Schedule; Ethanol; Female; Humans; Hypotension; Intensive Care Units; Length of Stay; Male; Middle Aged; Respiration, Artificial; Retrospective Studies; Standard of Care; Substance Withdrawal Syndrome; Treatment Outcome

2016
Dexmedetomidine for acute baclofen withdrawal.
    Neurocritical care, 2015, Volume: 22, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Baclofen; Cerebral Palsy; Dexmedetomidine; GABA-B Receptor Agonists; Humans; Male; Quadriplegia; Substance Withdrawal Syndrome

2015
Outcomes of Patients with Alcohol Withdrawal Syndrome Treated with High-Dose Sedatives and Deferred Intubation.
    Annals of the American Thoracic Society, 2016, Volume: 13, Issue:2

    Topics: Adult; Alcohol Withdrawal Seizures; APACHE; Central Nervous System Depressants; Cohort Studies; Critical Illness; Dexmedetomidine; Ethanol; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Intubation, Intratracheal; Length of Stay; Logistic Models; Lorazepam; Male; Midazolam; Middle Aged; Pneumonia; Propofol; Respiration, Artificial; Retrospective Studies; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome

2016
Potential risk factors for dexmedetomidine withdrawal seizures in infants after surgery for congenital heart disease.
    Brain & development, 2016, Volume: 38, Issue:7

    Topics: Cardiovascular Surgical Procedures; Dexmedetomidine; Female; Fever; Heart Defects, Congenital; Humans; Hypnotics and Sedatives; Incidence; Infant; Male; Postoperative Complications; Retrospective Studies; Risk Factors; Seizures; Substance Withdrawal Syndrome

2016
Letter in Response to Evaluation of Early Dexmedetomidine Addition to the Standard of Care for Severe Alcohol Withdrawal in the ICU: A Retrospective Controlled Cohort Study.
    Journal of intensive care medicine, 2016, Volume: 31, Issue:5

    Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Retrospective Studies; Standard of Care; Substance Withdrawal Syndrome

2016
Treatment of Alcohol Withdrawal Syndrome with and without Dexmedetomidine.
    The Permanente journal, 2016,Spring, Volume: 20, Issue:2

    Topics: Adult; Aged; Alcoholism; Dexmedetomidine; Female; Humans; Intensive Care Units; Male; Middle Aged; Patient Safety; Retrospective Studies; Substance Withdrawal Syndrome; Treatment Outcome

2016
Severe GHB withdrawal delirium managed with dexmedetomidine.
    The Medical journal of Australia, 2016, Sep-19, Volume: 205, Issue:6

    Topics: Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Sodium Oxybate; Substance Withdrawal Syndrome; Young Adult

2016
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:5

    Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Sedatives; Intensive Care Units; Ketamine; Lorazepam; Male; Midazolam; Propofol; Quetiapine Fumarate; Respiration, Artificial; Substance Withdrawal Syndrome; Substance-Related Disorders

2017
Use of dexmedetomidine to treat delirium primarily caused by cannabis.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:3

    Topics: Administration, Intravenous; Cannabis; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Marijuana Abuse; Marijuana Smoking; Substance Withdrawal Syndrome; Young Adult

2017
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
    JAMA, 2009, Jun-17, Volume: 301, Issue:23

    Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Respiration, Artificial; Sepsis; Substance Withdrawal Syndrome

2009
Withdrawal from multiple sedative agent therapy in an infant: is dexmedetomidine the cause or the cure?
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2010, Volume: 11, Issue:1

    Topics: Adrenergic alpha-Agonists; Dexmedetomidine; Hospitals, Pediatric; Humans; Infant; Intensive Care Units, Neonatal; Substance Withdrawal Syndrome; Ventilator Weaning

2010
Dexmedetomidine: are tolerance and withdrawal going to be an issue with long-term infusions?.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2010, Volume: 11, Issue:1

    Topics: Adrenergic alpha-Agonists; Child; Critical Illness; Dexmedetomidine; Humans; Infant; Substance Withdrawal Syndrome; Ventilator Weaning

2010
The use of dexmedetomidine in alcohol withdrawal.
    The Journal of neuropsychiatry and clinical neurosciences, 2012,Summer, Volume: 24, Issue:3

    Topics: Adult; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Substance Withdrawal Syndrome

2012
Two cases of acute dexmedetomidine withdrawal syndrome following prolonged infusion in the intensive care unit: Report of cases and review of the literature.
    Human & experimental toxicology, 2013, Volume: 32, Issue:1

    Topics: Clonidine; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Intensive Care Units; Middle Aged; Substance Withdrawal Syndrome; Sympatholytics

2013
Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Dexmedetomidine; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Ion Channels; Male; Mice; Mice, Inbred C57BL; Morphine; Pain Threshold; Physical Stimulation; Substance Withdrawal Syndrome

2003
Dexmedetomidine to facilitate drug withdrawal.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Alcohol Drinking; Blood Pressure; Cocaine-Related Disorders; Dexmedetomidine; Female; Heart Rate; Humans; Hypertension; Hypnotics and Sedatives; Lorazepam; Male; Middle Aged; Psychomotor Agitation; Respiration, Artificial; Substance Withdrawal Syndrome

2003
Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:4

    Topics: Acinetobacter Infections; Adult; Analgesics, Opioid; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Lorazepam; Male; Pneumonia; Psychomotor Agitation; Respiratory Distress Syndrome; Substance Withdrawal Syndrome; Substance-Related Disorders; Ventilator Weaning; Ventilators, Mechanical

2003
The use of dexmedetomidine to facilitate opioid and benzodiazepine detoxification in an infant.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Analgesics, Opioid; Benzodiazepines; Dexmedetomidine; Electroencephalography; Humans; Inactivation, Metabolic; Infant; Male; Substance Withdrawal Syndrome

2004
The use of dexmedetomidine to facilitate acute discontinuation of opioids after cardiac transplantation in children.
    Critical care medicine, 2005, Volume: 33, Issue:9

    Topics: Adrenergic alpha-Agonists; Benzodiazepines; Child; Dexmedetomidine; Heart Transplantation; Humans; Infant; Intensive Care Units, Pediatric; Male; Narcotics; Substance Withdrawal Syndrome

2005
Medications to provide cooperation in the critically ill pediatric patient: a rose with a thorn.
    Critical care medicine, 2005, Volume: 33, Issue:9

    Topics: Adrenergic alpha-Agonists; Adult; Child; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Propofol; Substance Withdrawal Syndrome

2005
Using dexmedetomidine to manage patients with cocaine and opioid withdrawal, who are undergoing cerebral angioplasty for cerebral vasospasm.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:6

    Topics: Angioplasty; Cocaine-Related Disorders; Dexmedetomidine; Female; Humans; Middle Aged; Opioid-Related Disorders; Substance Withdrawal Syndrome; Vasospasm, Intracranial

2006
Acute discontinuation syndrome from dexmedetomidine after protracted use in a pediatric patient.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:1

    Topics: Analgesia, Epidural; Blood Pressure; Cardiac Catheterization; Cardiovascular Diseases; Child, Preschool; Dexmedetomidine; Fontan Procedure; Heart Rate; Humans; Hypnotics and Sedatives; Hypoplastic Left Heart Syndrome; Male; Midazolam; Substance Withdrawal Syndrome

2008