dexmedetomidine has been researched along with Cognitive Dysfunction in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 22 (36.67) | 24.3611 |
| 2020's | 38 (63.33) | 2.80 |
| Authors | Studies |
|---|---|
| Du, H; Jia, L; Lyu, J; Sheng, M; Yu, H; Yu, W | 1 |
| Chen, S; He, S; Sun, Z; Wei, W; Zhang, W | 1 |
| Deng, S; Gong, Y; Jin, P; Lenahan, C; Tan, J; Tian, M; Wang, K; Wang, W; Wang, Y; Wen, H; Zhao, F | 1 |
| Liu, Y; Zhang, H; Zhang, W | 1 |
| He, J; Li, J; Rong, J; Wang, Z; Xun, X; Yin, Q; Yu, D | 1 |
| Gao, XP; Wang, F; Wu, L; Xie, D; Xu, H; Ye, Q | 1 |
| Chen, K; Jin, Z; Li, M; Wang, Y; Zhan, J | 1 |
| Fan, Y; Hu, R; Liao, XZ; Liu, YF; Xiao, JF; Zhang, LF | 1 |
| Brenna, CTA; Broad, J; Choi, S; Kaustov, L; Singh, A | 1 |
| Kong, G; Liu, J; Tang, Y; Wang, Y; Wei, L; Zhao, Y | 1 |
| Busund, R; Haaverstad, R; Helbostad, JL; Landsverk, SA; Martinaityte, I; Neerland, BE; Norum, HM; Ræder, J; Selbaek, G; Simpson, MR; Skaar, E; Skjærvold, NK; Skovlund, E; Slooter, AJ; Svendsen, ØS; Tønnessen, T; Wahba, A; Wyller, TB; Zetterberg, H | 1 |
| Cao, G; Fan, J; Kang, H; Liu, B; Yu, H | 1 |
| Liu, Y; Ma, Y; Wang, P; Wang, W | 1 |
| Li, G; Liu, B; Wei, J; Zhou, J | 1 |
| Cho, I; Kam, EH; Kim, EJ; Kim, J; Kim, SY; Koo, BN; Park, S | 1 |
| Tao, Q; Yang, N; Yu, J | 1 |
| Li, J; Zhang, H; Zhao, W | 1 |
| He, H; Lyu, Y; Qi, Y; Yuan, Y; Zhu, M | 1 |
| Cui, Y; Li, XF; Lv, J; Zeng, T; Zhang, Q | 1 |
| Chu, T; Liu, C; Wang, J; Xin, Y; Xu, A; Zhou, Y | 1 |
| Akeju, O; Albanese, M; Baker, S; Houle, TT; Mekonnen, J; Mueller, A; Namirembe, GE; Qu, JZ; Westover, MB; Wiredu, K | 1 |
| Huang, Y; Xu, L; Xu, S; Zhang, Y | 1 |
| Wu, A; Yang, Z; Zhang, M | 1 |
| Gao, Y; Huang, L; Li, F; Teng, J; Zhu, X | 1 |
| Gou, B; Huang, J; Rong, F; Wang, W | 1 |
| Lai, IK; Li, R; Maze, M; Pan, JZ; Zhang, P | 1 |
| Coopersmith, CM; Paterson, CW | 1 |
| Li, C; Sun, W; Zhao, J | 1 |
| Cui, E; Li, M; Sun, J; Yan, M; Zhang, H; Zhang, Y; Zhou, J; Zhu, X | 1 |
| Dong, Y; Li, M; Liang, F; Soriano, SG; Sun, M; Xie, Z; Zhang, J; Zhang, Y | 1 |
| Arnold, C | 1 |
| Chen, J; Hua, W; Wang, H; Xin, X | 1 |
| Chen, J; Ding, H; Li, C; Wang, J; Xia, Z; Ye, J | 1 |
| Wu, Y; Yang, L; Yang, Y; Yuan, J | 1 |
| Bi, X; Wei, J; Zhang, X | 1 |
| Hu, B; Tao, X; Tian, T; Xue, FS | 1 |
| Chen, Y; Du, J; Feng, JG; Jia, J; Liu, KX; Tan, SL; Zhang, Y; Zhou, J | 1 |
| Li, M; Ma, Y; Wang, Q; Yang, Y | 1 |
| Berian, JR; Robinson, TN; Rosenthal, RA | 1 |
| Arora, H; Bergese, SD; Candiotti, K; Deiner, S; Flaherty, JH; Jankowski, C; Lee, HB; Lin, HM; Luo, X; Rock, P; Saager, L; Sano, M; Sessler, DI; Shander, A; Sieber, FE | 1 |
| Chen, G; Lu, J; Wu, C; Zhou, H; Zhou, Q; Zhu, Z | 1 |
| Feng, X; Hu, J; Lai, IK; Lutrin, D; Maze, M; Uchida, Y; Vacas, S | 1 |
| Chen, S; Cheng, X; Gu, E; Liu, X; Mei, B; Meng, G; Xu, G; Zhang, M; Zhang, Y | 1 |
| Chen, QH; Hu, Q; Huang, HJ; Liang, SS; Lou, FQ; Wang, WX; Wu, Q; Xu, L; Zhang, XK | 1 |
| Carr, ZJ; Cios, TJ; Potter, KF; Swick, JT | 1 |
| Alam, A; Hana, Z; Jin, Z; Ma, D; Suen, KC | 1 |
| Chen, Y; Fang, S; Li, Y; Xu, G; Yang, Y; Yao, P | 1 |
| Du, X; Mi, W; Yu, J | 1 |
| Qiao, Y; Wu, Z; Zhang, H; Zhao, X | 1 |
| Luo, FQ; Min, J; Xiong, YF; Zhu, YS | 1 |
| Liu, F; Liu, Y; Ma, Y; Wang, W | 1 |
| Ao, JS; Chen, C; Li, WX; Li, X; Liu, Y; Luo, RY; Yin, YQ | 1 |
| Cheng, XQ; Gu, E; Liu, XS; Mei, B; Peng, XH; Wu, H; Zhao, Q; Zuo, YM | 1 |
| Chen, LR; Kong, LS; Liu, Y; Wang, RX; Yang, W; Zhu, XX | 1 |
| Cui, J; Gu, X; Qian, H; Zhang, J; Zhang, X | 1 |
| Gao, M; Guo, W; Liu, Y; Ma, L; Ma, Y | 1 |
| Guo, X; Han, B; Mao, M; Wang, J; Wang, Y; Wu, C; Xu, F | 1 |
| Han, XP; Li, LL; Sun, ZT; Xu, G; Zhang, W | 1 |
| Aoyama, B; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M | 1 |
| Liu, Z; Ruan, L; Zhou, C; Zhu, Y | 1 |
12 review(s) available for dexmedetomidine and Cognitive Dysfunction
| Article | Year |
|---|---|
The effect of intraoperative dexmedetomidine on cognitive dysfunction after surgery: a updated meta-analysis.
Topics: Anesthesia, General; Cognitive Dysfunction; Dexmedetomidine; Humans; Postoperative Period | 2021 |
The Effects of Dexmedetomidine on Perioperative Neurocognitive Outcomes After Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Topics: Adult; Cardiac Surgical Procedures; Cognitive Dysfunction; Dexmedetomidine; Humans; Postoperative Period; Randomized Controlled Trials as Topic | 2022 |
Influence of dexmedetomidine on postoperative cognitive dysfunction in the elderly: A meta-analysis of randomized controlled trials.
Topics: Aged; Anesthesia, General; Cognitive Dysfunction; Dexmedetomidine; Humans; Postoperative Cognitive Complications; Postoperative Complications; Randomized Controlled Trials as Topic | 2022 |
Effectiveness of dexmedetomidine on postoperative cognitive dysfunction in elderly patients with fracture: A systematic review.
Topics: Aged; Cognition; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Postoperative Cognitive Complications; Postoperative Complications; Randomized Controlled Trials as Topic | 2023 |
Effects of anesthetic adjunctive agents on postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery: A Bayesian network meta-analysis.
Topics: Adjuvants, Anesthesia; Aged; Anesthetics; Bayes Theorem; Cognitive Dysfunction; Dexmedetomidine; Humans; Ketamine; Network Meta-Analysis; Postoperative Cognitive Complications; Postoperative Complications | 2023 |
Effects of dexmedetomidine on early cognitive function in elderly patients after abdominal surgery: a meta-analysis.
Topics: Aged; Anesthesia, General; Cognition; Cognitive Dysfunction; Dexmedetomidine; Humans; Postoperative Complications | 2023 |
Effects of dexmedetomidine on neurocognitive disturbance after elective non-cardiac surgery in senile patients: a systematic review and meta-analysis.
Topics: China; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Hypotension; Postoperative Complications | 2021 |
Pharmacological Agents That Prevent Postoperative Cognitive Dysfunction in Patients With General Anesthesia: A Network Meta-analysis.
Topics: Anesthesia, General; Bayes Theorem; Cognitive Dysfunction; Dexmedetomidine; Humans; Ketamine; Network Meta-Analysis; Postoperative Cognitive Complications | 2020 |
Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature.
Topics: Aged; Animals; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Postoperative Complications | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibuprofen; Inflammation; Postoperative Complications | 2018 |
Effect of dexmedetomidine on postoperative cognitive dysfunction and inflammation in patients after general anaesthesia: A PRISMA-compliant systematic review and meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia, General; China; Cognitive Dysfunction; Dexmedetomidine; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Mental Status and Dementia Tests; Odds Ratio; Perioperative Period; Postoperative Complications; Randomized Controlled Trials as Topic; Tumor Necrosis Factor-alpha | 2019 |
Effect of dexmedetomidine on postoperative cognitive dysfunction in elderly patients after general anaesthesia: A meta-analysis.
Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anesthesia, General; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Male; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Surgical Procedures, Operative | 2016 |
14 trial(s) available for dexmedetomidine and Cognitive Dysfunction
| Article | Year |
|---|---|
The effects of remifentanil-propofol combined with dexmedetomidine on cognitive dysfunction in elderly patients after ureteroscopic holmium laser lithotripsy: a double-blind randomized controlled trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Double-Blind Method; Holmium; Humans; Lithotripsy, Laser; Propofol; Remifentanil; Ureteroscopy | 2022 |
Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy.
Topics: Aged; Aged, 80 and over; Bradycardia; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Hypotension; Interleukin-10; Middle Aged; Postoperative Cognitive Complications; Postoperative Complications; Prospective Studies; Tumor Necrosis Factor-alpha | 2022 |
Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Cardiac Surgical Procedures; Clonidine; Cognitive Dysfunction; Delirium; Dexmedetomidine; Double-Blind Method; Frailty; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic | 2022 |
Effects of Dexmedetomidine Anesthesia on Early Postoperative Cognitive Dysfunction in Elderly Patients.
Topics: Aged; Anesthesia; Cognitive Dysfunction; Dexmedetomidine; Humans; Inflammation; Postoperative Cognitive Complications; Postoperative Complications | 2022 |
Effect of dexmedetomidine on postoperative cognitive dysfunction in elderly patients undergoing orthopaedic surgery: study protocol for a randomized controlled trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Double-Blind Method; Humans; Orthopedic Procedures; Postoperative Cognitive Complications; Prospective Studies; Randomized Controlled Trials as Topic | 2023 |
Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Tria
Topics: Aged; Cardiac Surgical Procedures; Cognitive Dysfunction; Delirium; Dexmedetomidine; Emergence Delirium; Humans; Intensive Care Units; Postoperative Complications; Sleep | 2023 |
Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Cognitive Dysfunction; Delirium; Dexmedetomidine; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Infusions, Intravenous; Intraoperative Care; Male; Postoperative Complications; Treatment Failure | 2017 |
Effect of parecoxib sodium pretreatment combined with dexmedetomidine on early postoperative cognitive dysfunction in elderly patients after shoulder arthroscopy: A randomized double blinded controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroscopy; Bradycardia; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Cyclooxygenase 2 Inhibitors; Dexmedetomidine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Humans; Incidence; Isoxazoles; Middle Aged; Oxygen; Pain, Postoperative; Partial Pressure; Perioperative Period; Postoperative Nausea and Vomiting; Respiratory Insufficiency; Shoulder; Sufentanil; Treatment Outcome | 2017 |
Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study.
Topics: Aged; Arthroplasty, Replacement, Hip; Cognitive Dysfunction; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Incidence; Male; Nerve Block; Postoperative Complications; Propofol; Treatment Outcome | 2018 |
The effect of dexmedetomidine on the perioperative hemodynamics and postoperative cognitive function of elderly patients with hypertension: Study protocol for a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Cognition; Cognitive Dysfunction; Dexmedetomidine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Hemodynamics; Humans; Hypertension; Hypnotics and Sedatives; Male; Middle Aged; Postoperative Complications; Preoperative Period; Prospective Studies; Treatment Outcome | 2018 |
Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Neuropsychological Tests; Postoperative Complications; Propofol; Prospective Studies | 2019 |
A multicentre randomised controlled trial of the effect of intra-operative dexmedetomidine on cognitive decline after surgery.
Topics: Aged; Aged, 80 and over; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Intraoperative Care; Male; Postoperative Complications; Prospective Studies | 2019 |
Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement; Cognitive Dysfunction; Delirium; Dexmedetomidine; Female; Humans; Male; Postoperative Complications; Prospective Studies | 2016 |
Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction and Serum Levels of b-Amyloid and Neuronal Microtubule-Associated Protein in Orthotopic Liver Transplantation Patients.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Amyloid beta-Peptides; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Liver Transplantation; Male; Middle Aged; Neuropsychological Tests; Postoperative Complications; Risk Factors; tau Proteins; Young Adult | 2016 |
34 other study(ies) available for dexmedetomidine and Cognitive Dysfunction
| Article | Year |
|---|---|
Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Inflammasomes; Ischemia; Liver; Liver Diseases; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirtuins | 2020 |
Protective role of dexmedetomidine against sevoflurane-induced postoperative cognitive dysfunction via the microRNA-129/TLR4 axis.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; MicroRNAs; Postoperative Cognitive Complications; Rats; Sevoflurane; Toll-Like Receptor 4 | 2021 |
Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1/Th2/Th17 polarization in an experimental sepsis model of mice.
Topics: Animals; Blood-Brain Barrier; Cecum; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Hippocampus; Inflammation; Male; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Sepsis; Th17 Cells | 2021 |
Effect of Dexmedetomidine Combined with Ropivacaine on Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Craniocerebral Surgery.
Topics: Analgesics; Anesthesia; Cognitive Dysfunction; Dexmedetomidine; Female; Heart Rate; Humans; Inflammation; Male; Middle Aged; Oxygen Saturation; Pain Measurement; Ropivacaine | 2021 |
Dexmedetomidine improved one-lung ventilation-induced cognitive dysfunction in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; bcl-2-Associated X Protein; Cognitive Dysfunction; Dexmedetomidine; One-Lung Ventilation; Rats; Rats, Sprague-Dawley | 2022 |
Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF-1α/PFKFB3 axis in a murine model of postoperative cognitive dysfunction.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; Disease Models, Animal; Hippocampus; Histone Deacetylase 2; Hypoxia-Inducible Factor 1, alpha Subunit; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Phosphofructokinase-2; Postoperative Cognitive Complications | 2022 |
Dexmedetomidine Ameliorated Cognitive Dysfunction Induced by Intestinal Ischemia Reperfusion in Mice with Possible Relation to the Anti-inflammatory Effect Through the Locus Coeruleus Norepinephrine System.
Topics: Adrenergic Antagonists; Animals; Anti-Inflammatory Agents; Benzylamines; Cognitive Dysfunction; Dexmedetomidine; Eosine Yellowish-(YS); Hematoxylin; Ischemia; Locus Coeruleus; Malondialdehyde; Mice; Neuroprotective Agents; Neurotoxins; Norepinephrine; Reperfusion; Reperfusion Injury; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Yohimbine | 2022 |
Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; Inflammasomes; Mice; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Postoperative Cognitive Complications; Signal Transduction | 2022 |
Comment on "Effects of Dexmedetomidine Anesthesia on Early Postoperative Cognitive Dysfunction in Elderly Patients".
Topics: Aged; Anesthesia; Cognitive Dysfunction; Dexmedetomidine; Humans; Postoperative Cognitive Complications | 2023 |
Effects and possible mechanisms of dexmedetomidine on post-operative cognitive dysfunction.
Topics: Cognitive Dysfunction; Dexmedetomidine; Humans; Hypnotics and Sedatives | 2023 |
Dexmedetomidine mitigates neuroinflammation and improves early postoperative neurocognitive dysfunction in rats by enhancing autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Beclin-1; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Hippocampus; Neuroinflammatory Diseases; Postoperative Cognitive Complications; Rats; Rats, Sprague-Dawley | 2023 |
Effects of dexmedetomidine on cerebral oxygen saturation and postoperative cognitive function in elderly patients undergoing minimally invasive coronary artery bypass surgery.
Topics: Aged; Analgesics, Non-Narcotic; Cognition; Cognitive Dysfunction; Coronary Artery Bypass; Dexmedetomidine; Female; Humans; Male; Postoperative Period; Pulmonary Gas Exchange | 2020 |
Dexmedetomidine improves neurodevelopment and cognitive impairment in infants with congenital heart disease.
Topics: Cognitive Dysfunction; Dexmedetomidine; Female; Heart Defects, Congenital; Humans; Incidence; Infant; Intelligence Tests; Length of Stay; Male; Postoperative Complications; Retrospective Studies; Thoracic Surgical Procedures | 2020 |
Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Critical Illness; Dexmedetomidine; Lipopolysaccharides; Male; Mice; Receptors, Adrenergic; Rodentia; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine and Cognitive Dysfunction after Critical Illness: What Can (and Cannot) Be Extrapolated from Rodent Models.
Topics: Analgesics, Non-Narcotic; Animals; Cognitive Dysfunction; Critical Care; Critical Illness; Dexmedetomidine; Disease Models, Animal; Humans; Mice; Rodentia | 2020 |
Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer's Disease by Mediating the miR-129/YAP1/JAG1 Axis.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Apoptosis; Base Sequence; Cognitive Dysfunction; Dexmedetomidine; Gene Expression Regulation; Hippocampus; Jagged-1 Protein; Male; Mice; MicroRNAs; Models, Biological; Neurons; Neuroprotection; Neuroprotective Agents; Protein Binding; Signal Transduction; YAP-Signaling Proteins | 2020 |
Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Caspase 3; Cognitive Dysfunction; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Morris Water Maze Test; Random Allocation; Sevoflurane; Superoxide Dismutase; Treatment Outcome; Yohimbine | 2021 |
Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Age Factors; Animals; Behavior, Animal; Clonidine; Cognition; Cognitive Dysfunction; Dexmedetomidine; Disease Models, Animal; Exploratory Behavior; Female; Hippocampus; Male; Mice, Inbred C57BL; Morris Water Maze Test; Phosphorylation; Receptors, Adrenergic, alpha-2; Sevoflurane; tau Proteins | 2021 |
Could COVID delirium bring on dementia?
Topics: Cognitive Dysfunction; COVID-19; Critical Illness; Delirium; Dementia; Dexmedetomidine; Follow-Up Studies; Humans | 2020 |
Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment.
Topics: Aged; Anesthesia, General; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Postoperative Complications | 2021 |
Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy.
Topics: Adrenergic alpha-2 Receptor Agonists; Autophagy; Cell Line; Cognitive Dysfunction; Dexmedetomidine; Ferritins; Hippocampus; Humans; Inflammation; Methotrexate; Neuroprotective Agents; Nuclear Receptor Coactivators | 2021 |
[Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats].
Topics: Animals; Animals, Newborn; beta Catenin; Cognitive Dysfunction; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Rats; Rats, Sprague-Dawley; Sevoflurane; Wnt Signaling Pathway | 2021 |
In reference to intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment.
Topics: Aged; Cognitive Dysfunction; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives | 2021 |
Dexmedetomidine alleviates neuroinflammation, restores sleep disorders and neurobehavioral abnormalities in rats with minimal hepatic encephalopathy.
Topics: Adrenergic alpha-2 Receptor Agonists; Ammonia; Animals; Anti-Inflammatory Agents; Anxiety; Behavior, Animal; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Hepatic Encephalopathy; Inflammasomes; Liver; Male; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; Prefrontal Cortex; Rats, Sprague-Dawley; Sleep Wake Disorders | 2021 |
Confusion Regarding Surgical Delirium-Is Dexmedetomidine the Answer?
Topics: Aged; Cognitive Dysfunction; Delirium; Dexmedetomidine; Elective Surgical Procedures; Humans | 2017 |
Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice.
Topics: Animals; Blood-Brain Barrier; Cognitive Dysfunction; Dexmedetomidine; HMGB1 Protein; Imidazoline Receptors; Inflammation; Male; Mice; Mice, Inbred C57BL; Netrin-1; Receptors, Nicotinic; Vagus Nerve | 2018 |
Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction.
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; Doublecortin Protein; Encephalitis; Hippocampus; Male; Neurogenesis; Neurons; Neuroprotective Agents; Postoperative Complications; Rats, Sprague-Dawley; Signal Transduction; Spatial Memory | 2018 |
[Dexmedetomidine alleviates postoperative cognitive dysfunction in aged rats probably
Topics: Age Factors; Animals; Carbazoles; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Interleukin-6; Laparotomy; Male; Maze Learning; NF-kappa B; Postoperative Complications; Random Allocation; Rats; Rats, Sprague-Dawley; Sirtuin 1; Tumor Necrosis Factor-alpha | 2018 |
Role of dexmedetomidine in reducing the incidence of postoperative cognitive dysfunction caused by sevoflurane inhalation anesthesia in elderly patients with esophageal carcinoma.
Topics: Age Factors; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anesthesia, General; Anesthetics, Inhalation; Biomarkers; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Esophageal Neoplasms; Female; Humans; Inflammation Mediators; Male; Postoperative Complications; S100 Calcium Binding Protein beta Subunit; Sevoflurane | 2018 |
Dexmedetomidine protects rats from postoperative cognitive dysfunction via regulating the GABA
Topics: Animals; Apoptosis; Cognitive Dysfunction; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dexmedetomidine; Encephalitis; Hippocampus; Male; Neurons; Neuroprotective Agents; Postoperative Complications; Rats, Sprague-Dawley; Receptors, GABA-B; Signal Transduction | 2019 |
Comparison of Cognitive Impairments After Intensive Care Unit Sedation Using Dexmedetomidine and Propofol Among Older Patients.
Topics: Aged; Aged, 80 and over; Anesthesia; Cognition; Cognitive Dysfunction; Cohort Studies; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Male; Propofol; Random Allocation | 2019 |
[Dexmedetomidine alleviates cognitive dysfunction induced by tibial fracture in rats].
Topics: Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Tibial Fractures | 2019 |
Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.
Topics: Analgesics; Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Blood Gas Analysis; Caspase 3; Cognitive Dysfunction; Dexmedetomidine; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Phosphatidylinositol 3-Kinases; Propofol; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Signal Transduction | 2016 |
Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats.
Topics: Aging; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Imidazoles; Inflammation; Isoindoles; Isoquinolines; Lipopolysaccharides; Male; Memory Disorders; Neuroprotective Agents; Piperazines; Rats; Signal Transduction | 2017 |