dexmedetomidine has been researched along with Brain Ischemia in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (11.11) | 29.6817 |
| 2010's | 23 (42.59) | 24.3611 |
| 2020's | 25 (46.30) | 2.80 |
| Authors | Studies |
|---|---|
| Han, H; Liu, W; Nie, H; Tian, K; Wang, N; Wang, S; Zhang, Y | 1 |
| Antunes, MA; Battaglini, D; Cruz, FF; da Silva, CM; Fernandes, MV; Pelosi, P; Robba, C; Rocco, PRM; Samary, CS; Silva, PL; Sousa, GC; Takyia, C | 1 |
| Lai, S; Li, G; Liu, Q; Wu, J | 1 |
| Chen, L; Dong, S; Duan, F; Hu, M; Huang, J; Men, Y; Zhang, Y | 1 |
| Cui, X; Ge, S; Li, Y; Zhang, L | 1 |
| He, J; Jiang, L; Li, J; Liu, H; Wang, K; Zhang, H | 1 |
| Cong, D; Meng, Y; Qi, X; Yu, Y | 1 |
| Gao, Y; He, Z; Su, H; Wang, L; Wu, H; Yan, S; Zhang, H | 1 |
| Ding, C; Han, GJ; Ma, SS; Min, XZ; Wang, XQ | 1 |
| Guo, Q; Han, Y; Ma, M; Yu, H; Zhang, D | 1 |
| Bao, X; Huang, L; Lyu, J; Sun, Z; Tang, L; Zhang, M; Zhao, L; Zhou, Y | 1 |
| Deng, H; Liu, J; Xie, K; Yu, J; Yu, L; Zhai, Y; Zhu, Y | 1 |
| Du, H; Guo, H; Hu, Z; Liu, W; Lv, J; Wang, L; Zhang, Y | 1 |
| Dong, S; Hu, M; Jiang, M; Liu, G; Men, Y; Sun, Z; Tong, X; Wang, X | 1 |
| Busl, KM; Doré, S; Liu, H | 1 |
| Cai, X; Huang, W; Li, Y; Wang, Q; Wang, Z; Ye, F; Zheng, X; Zuo, Z | 1 |
| Fang, H; Li, HF; Yan, JY; Yang, M; Zhang, JP | 1 |
| Chen, J; Chen, W; Cheng, Q; Li, Y; Lv, H | 1 |
| Ding, Z; Huang, L; Li, Z; Wang, J; Yang, J; Yuan, Z | 1 |
| Li, Z; Luo, X; Sun, K; Wu, K; Xie, W; Yang, Q; Zhang, J; Zhang, X; Zhu, J | 1 |
| Hao, S; Ling, Y; Liu, J; Yu, S; Zhao, Q | 1 |
| Liu, Y; Ma, X; Zhang, W; Zhao, H; Zhu, Y | 1 |
| Fan, D; Gu, P; Li, G | 1 |
| Ai, Y; He, L; Li, D; Zhang, S; Zhao, B | 1 |
| Liu, W; Shao, C; Sun, J; Wang, Y; Xu, M; Zang, C | 1 |
| Kim, E; Kim, HC; Kim, JH; Lee, S; Lim, YJ; Park, HP; Park, YH; Ryu, HG | 1 |
| Cao, Y; Chang, Y; Dai, Z; Hu, M; Jiang, L; Lu, Y | 1 |
| Fu, Z; Lin, S; Shao, W; Zhou, G | 1 |
| Duan, L; Liu, Z; Wang, GM; Wang, SL; Wang, Y; Xia, B | 1 |
| Gao, R; Huang, Z; Li, R; Liu, B; Liu, G; Wang, L; Yu, W; Yu, Y; Zeng, Q; Zhang, S; Zhao, A; Zhou, S | 1 |
| Han, XP; Jia, YP; Li, ZC; Qi, JL; Wang, Y | 1 |
| Cheng, J; Li, X; Peng, X; Qin, H; Yu, H; Zhu, P | 1 |
| Gao, GJ; Gu, PF; Li, Y; Shang, Y; Xue, Q | 1 |
| Dong, H; He, Z; Ma, X; Wang, Z; Zhou, W | 1 |
| Fang, T; Fu, Q; Liu, C; Mu, R; Tian, F; Wang, F; Yu, B; Zhang, L; Zhang, Y; Zhou, C | 1 |
| Chen, W; Teng, L; Yin, C; Zhang, H; Zhao, Q | 1 |
| Fang, X; Gao, J; Ge, Y; Li, Q; Luo, K; Nie, Y; Wang, C | 1 |
| Apan, A; Atilla, P; Bakar, B; Kasimcan, O; Kilinc, K; Kose, EA; Muftuoglu, S | 1 |
| Barsoum, S; Chi, OZ; Dinani, A; Grayson, J; Liu, X; Weiss, HR | 1 |
| Cao, YY; Ding, XD; Zhao, GY; Zhao, P; Zheng, NN | 1 |
| Gao, X; Gu, SL; Han, JP; Hu, B; Li, M; Ma, TF; Ma, X; Qin, SJ; Wu, YQ; Zhou, L | 1 |
| Dupler, S; Farag, E; Gomes, J; Hussain, MS; John, S; Somal, J; Thebo, U | 1 |
| Álvarez, J; Baluja, A; Castillo, J; del Río, SV; López, P; Rodríguez-García, J; Rodríguez-González, R; Sobrino, T; Veiga, S | 1 |
| Li, W; Wang, H; Wang, Q; Xing, X; Zeng, X | 1 |
| Akpınar, H; Akpınar, O; Nazıroğlu, M | 1 |
| Li, Y; Liu, S | 1 |
| Nakano, T; Okamoto, H | 1 |
| Kimura, T; Masaki, Y; Nishikawa, T; Sato, K; Tobe, Y | 1 |
| Chen, L; Ma, LL; Qian, LB; Wang, CC; Wen, CY; Yan, M; Yu, J; Yu, LN; Zhu, MH; Zhu, YM | 1 |
| Bachl, M; Blobner, M; Eberspächer, E; Engelhard, K; Hildt, E; Hutzler, P; Kochs, E; Werner, C | 1 |
| Dahmani, S; Gressens, P; Mantz, J; Rouelle, D | 1 |
| Aldemir, D; Dönmez, A; Sezgin, A; Sulemanji, DS; Türkoglu, S | 1 |
| Chen, Y; Hertz, L; Huang, R; Yu, AC | 1 |
| Bachl, M; Blobner, M; Engelhard, K; Kaspar, S; Kochs, E; Möllenberg, O; Werner, C | 1 |
2 review(s) available for dexmedetomidine and Brain Ischemia
| Article | Year |
|---|---|
Role of Dexmedetomidine in Aneurysmal Subarachnoid Hemorrhage: A Comprehensive Scoping Review.
Topics: Brain Ischemia; Dexmedetomidine; Humans; Retrospective Studies; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2022 |
The protective effects of dexmedetomidine on ischemic brain injury: A meta-analysis.
Topics: Adrenergic alpha-2 Receptor Agonists; Brain Injuries; Brain Ischemia; Dexmedetomidine; Humans; Inflammation Mediators; Intraoperative Care; Neuroprotective Agents; Neurosurgical Procedures | 2017 |
2 trial(s) available for dexmedetomidine and Brain Ischemia
| Article | Year |
|---|---|
Dexmedetomidine improves cognition after carotid endarterectomy by inhibiting cerebral inflammation and enhancing brain-derived neurotrophic factor expression.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Brain Ischemia; Brain-Derived Neurotrophic Factor; Carotid Stenosis; Case-Control Studies; Cognition Disorders; Dexmedetomidine; Endarterectomy, Carotid; Female; Follow-Up Studies; Gene Expression Regulation; Humans; Inflammation; Male; Prognosis | 2019 |
Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?--A preliminary study.
Topics: Aged; Anesthetics, Intravenous; Biomarkers; Blood Gas Analysis; Brain Ischemia; Coronary Artery Bypass; Dexmedetomidine; Female; Humans; Lactic Acid; Male; Middle Aged; Phosphopyruvate Hydratase; Protein S | 2007 |
50 other study(ies) available for dexmedetomidine and Brain Ischemia
| Article | Year |
|---|---|
Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Dexmedetomidine; Heme Oxygenase-1; Membrane Proteins; Mice; Microglia; Neuroprotective Agents; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Reperfusion Injury; Signal Transduction | 2022 |
Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Hypnotics and Sedatives; Interleukin-1beta; Interleukin-6; Ischemic Stroke; Lung; Macrophages, Alveolar; Male; Propofol; Rats; Rats, Wistar; Thiopental; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2021 |
MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF-κB Axis.
Topics: Animals; Apoptosis; Brain Ischemia; Cytokines; Dexmedetomidine; Glucose; Infarction, Middle Cerebral Artery; Ischemic Stroke; Mice; MicroRNAs; NF-kappa B; Oxygen; Reperfusion Injury; rho-Associated Kinases; Up-Regulation | 2022 |
Dexmedetomidine exerts its protective effect on cerebral ischemia reperfusion injury in mice by inhibiting ferroptosis.
Topics: Animals; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Ferroptosis; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Reperfusion Injury | 2022 |
Protective effects of brain-targeted dexmedetomidine nanomicelles on mitochondrial dysfunction in astrocytes of cerebral ischemia/reperfusion injury rats.
Topics: Animals; Apoptosis; Astrocytes; Brain; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Humans; Mitochondria; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2022 |
Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Interleukin-6; Janus Kinase 2; Male; Neuroinflammatory Diseases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine (Dex) exerts protective effects on rat neuronal cells injured by cerebral ischemia/reperfusion via regulating the Sphk1/S1P signaling pathway.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Cerebral Infarction; Dexmedetomidine; Neurons; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Signal Transduction | 2023 |
Dexmedetomidine treatment prevents cerebral ischemic reperfusion injury through HIF-1α/Beclin1-mediated autophagy.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Brain Ischemia; Dexmedetomidine; Humans; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Brain Ischemia; Dexmedetomidine; Hippocampus; Infarction, Middle Cerebral Artery; Kelch-Like ECH-Associated Protein 1; Mitophagy; NF-E2-Related Factor 2; Rats; Reperfusion Injury; Signal Transduction | 2022 |
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Topics: Animals; Apoptosis; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Ferredoxins; Homeostasis; Rats; Reperfusion; Reperfusion Injury | 2023 |
Neuroprotective Effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in Rats.
Topics: Animals; Brain Ischemia; Caspase 3; Cerebral Infarction; Dexmedetomidine; Glial Fibrillary Acidic Protein; Humans; Ischemic Stroke; Male; Methionyl Aminopeptidases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2023 |
Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway.
Topics: Animals; Brain Ischemia; Dexmedetomidine; HMGB1 Protein; Hydrogen Peroxide; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
Dexmedetomidine had neuroprotective effects on hippocampal neuronal cells via targeting lncRNA SHNG16 mediated microRNA-10b-5p/BDNF axis.
Topics: 3' Untranslated Regions; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cell Line; Cell Survival; Dexmedetomidine; Down-Regulation; Gene Expression Regulation; Hippocampus; Infarction, Middle Cerebral Artery; Mice; MicroRNAs; Neurons; Neuroprotection; Neuroprotective Agents; Rats; RNA, Long Noncoding; Signal Transduction; Up-Regulation | 2020 |
[Role of mitochondrial fusion and fission in protective effects of dexmedetomidine against cerebral ischemia/reperfusion injury in mice].
Topics: Animals; Brain Ischemia; Dexmedetomidine; Male; Mice; Mice, Inbred ICR; Mitochondrial Dynamics; Reperfusion Injury | 2020 |
Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43.
Topics: Animals; Astrocytes; Brain Ischemia; Connexin 43; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Male; Perioperative Care; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation | 2020 |
Dexmedetomidine-up-regulated microRNA-381 exerts anti-inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Glucose; Interferon Regulatory Factors; Interleukin-9; Male; MicroRNAs; Neurons; Oxygen; Pyramidal Cells; Rats; RNA Interference; Signal Transduction | 2021 |
Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Brain Ischemia; Cell Survival; Dexmedetomidine; Disease Models, Animal; Disks Large Homolog 4 Protein; Hippocampus; Histone Deacetylases; Male; Mice; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-mdm2; Signal Transduction | 2021 |
Protective effect of dexmedetomidine regulating AQP4 through ERK1/2 pathway against cerebral edema in cerebral trauma mice.
Topics: Animals; Brain Edema; Brain Ischemia; Dexmedetomidine; MAP Kinase Signaling System; Mice; Signal Transduction | 2023 |
Dexmedetomidine exerts a protective effect on ischemic brain injury by inhibiting the P2X7R/NLRP3/Caspase-1 signaling pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brain Chemistry; Brain Edema; Brain Ischemia; Caspase 1; Dexmedetomidine; Infarction, Middle Cerebral Artery; Male; Microglia; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Signal Transduction | 2021 |
The Protective Effects of Dexmedetomidine against Hypoxia/Reoxygenation-Induced Inflammatory Injury and Permeability in Brain Endothelial Cells Mediated by Sigma-1 Receptor.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Dexmedetomidine; Endothelial Cells; Hypoxia; Infarction, Middle Cerebral Artery; Mice; Permeability; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor | 2021 |
Dexmedetomidine attenuates neuronal injury induced by cerebral ischemia‑reperfusion by regulating miR‑199a.
Topics: Animals; Antigens, Nuclear; Beclin-1; Brain Ischemia; Caspase 3; Cerebral Cortex; Dexmedetomidine; Disease Models, Animal; Infarction, Middle Cerebral Artery; Injections; Male; MicroRNAs; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; RNA-Binding Proteins | 2021 |
Dexmedetomidine post-conditioning attenuates cerebral ischemia following asphyxia cardiac arrest through down-regulation of apoptosis and neuroinflammation in rats.
Topics: Animals; Apoptosis; Asphyxia; Brain Ischemia; Cardiopulmonary Resuscitation; Dexmedetomidine; Disease Models, Animal; Down-Regulation; Heart Arrest; Interleukin-1beta; Male; Neuroinflammatory Diseases; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Time Factors | 2021 |
Dexmedetomidine attenuates cerebral ischemia-reperfusion injury in rats by inhibiting the JNK pathway.
Topics: Animals; Brain Ischemia; Dexmedetomidine; MAP Kinase Signaling System; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Protective effects of dexmedetomidine on cerebral ischemia/reperfusion injury via the microRNA-214/ROCK1/NF-κB axis.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; MicroRNAs; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; rho-Associated Kinases | 2021 |
Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Dexmedetomidine; Encephalitis; Hippocampus; Inflammation; Inflammation Mediators; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2017 |
Impact of dexmedetomidine on amino acid contents and the cerebral ultrastructure of rats with cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; gamma-Aminobutyric Acid; Glutamine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2017 |
Dexmedetomidine preconditioning plays a neuroprotective role and suppresses TLR4/NF-κB pathways model of cerebral ischemia reperfusion.
Topics: Animals; Brain Ischemia; Dexmedetomidine; Infarction, Middle Cerebral Artery; Interferon-beta; Ischemia; Male; Neuroprotection; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2017 |
MiR-29b expression is associated with a dexmedetomidine-mediated protective effect against oxygen-glucose deprivation-induced injury to SK-N-SH cells in vitro.
Topics: Apoptosis; Brain; Brain Ischemia; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Dexmedetomidine; Glucose; Humans; MicroRNAs; Neurons; Oxygen; Signal Transduction; Stroke | 2018 |
Effects of dexmedetomidine post‑treatment on BDNF and VEGF expression following cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Line; Dexmedetomidine; Gene Expression Regulation; Male; Rats; Reperfusion Injury; RNA, Messenger; Vascular Endothelial Growth Factor A | 2018 |
Dexmedetomidine attenuates cerebral ischemia/reperfusion injury in neonatal rats by inhibiting TLR4 signaling.
Topics: Animals; Brain; Brain Ischemia; CA3 Region, Hippocampal; Cerebral Cortex; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Lipopolysaccharides; Neuroprotective Agents; Pilot Projects; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Toll-Like Receptor 4 | 2018 |
[Effect of dexmedetomidine on the changes of EAA and the expression of NMDA NR1 protein in hippocampus in global cerebral ischemia/reperfusion rats].
Topics: Animals; Brain Ischemia; Dexmedetomidine; Excitatory Amino Acids; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2016 |
Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK.
Topics: Adenylate Kinase; Animals; Apoptosis; Brain Ischemia; Cerebral Cortex; Dexmedetomidine; Enzyme Activation; Infarction, Middle Cerebral Artery; Inflammation; Male; Motor Activity; Neurons; Phosphorylation; Rats, Sprague-Dawley; Reperfusion Injury | 2018 |
Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Caspases; Dexmedetomidine; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotection; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Transcription Factor CHOP | 2018 |
Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats via Extracellular Signal-Regulated Kinase/Cyclic Adenosine Monophosphate Response Element Binding Protein Signaling Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Cell Death; Dexmedetomidine; Extracellular Signal-Regulated MAP Kinases; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2019 |
Effects of intracisternal and intravenous dexmedetomidine on ischemia-induced brain injury in rat: a comparative study.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Blood Pressure; Brain Diseases; Brain Ischemia; Cisterna Magna; Dexmedetomidine; Hippocampus; Injections; Injections, Intravenous; Lipid Peroxidation; Male; Rats; Rats, Wistar | 2013 |
Effects of dexmedetomidine on microregional O2 balance during reperfusion after focal cerebral ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Hemodynamics; Infarction, Middle Cerebral Artery; Male; Oxygen Consumption; Pons; Rats; Rats, Inbred F344; Reperfusion Injury | 2015 |
Dexmedetomidine preconditioning attenuates global cerebral ischemic injury following asphyxial cardiac arrest.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Asphyxia; Brain; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Heart Arrest; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemic Preconditioning; Neurons; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2016 |
Dexmedetomidine prevents post-ischemic LTP via presynaptic and postsynaptic mechanisms.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brain Ischemia; CA1 Region, Hippocampal; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexmedetomidine; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Long-Term Potentiation; Miniature Postsynaptic Potentials; Neuroprotective Agents; Norepinephrine; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tissue Culture Techniques | 2015 |
Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy.
Topics: Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Dexmedetomidine; Diffusion Magnetic Resonance Imaging; Female; Heart Rate; Hemodynamics; Humans; Hypnotics and Sedatives; Infusions, Intra-Arterial; Male; Middle Aged; Propofol; Retrospective Studies; Stroke; Treatment Outcome | 2015 |
Neuroprotective effects of dexmedetomidine conditioning strategies: Evidences from an in vitro model of cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Dexmedetomidine; In Vitro Techniques; Interleukin-6; Ischemic Postconditioning; Ischemic Preconditioning; Necrosis; Neuroprotective Agents; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2016 |
Dexmedetomidine Protects against Transient Global Cerebral Ischemia/Reperfusion Induced Oxidative Stress and Inflammation in Diabetic Rats.
Topics: Animals; Brain Ischemia; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Hemodynamics; Inflammation; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Brain; Brain Ischemia; Caspase 1; Cytokines; Dexmedetomidine; Disease Models, Animal; Glutathione; Inflammation Mediators; Liver; Male; Malondialdehyde; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Rats, Wistar | 2017 |
The Effect of Dexmedetomidine on Oxidative Stress Response Following Cerebral Ischemia-Reperfusion in Rats and the Expression of Intracellular Adhesion Molecule-1 (ICAM-1) and S100B.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dexmedetomidine; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; S100 Calcium Binding Protein beta Subunit; Superoxide Dismutase | 2017 |
Dexmedetomidine-induced cerebral hypoperfusion exacerbates ischemic brain injury in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Hypnotics and Sedatives; Infarction, Middle Cerebral Artery; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Resistance; Yohimbine | 2009 |
Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Carbon Dioxide; Cell Survival; Cerebrovascular Circulation; Combined Modality Therapy; Consciousness; Dexmedetomidine; Hypnotics and Sedatives; Hypothermia, Induced; Male; Muscle Tonus; Nervous System Diseases; Neuroprotective Agents; Pain; Postural Balance; Rats; Rats, Sprague-Dawley; Walking | 2010 |
Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Cerebral Cortex; Dexmedetomidine; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Infarction, Middle Cerebral Artery; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2013 |
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Apoptosis; Blood Gas Analysis; Blotting, Western; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Dexmedetomidine; Fluorescent Antibody Technique; Gene Expression Regulation; Hemodynamics; Ketamine; Male; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2003 |
Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Brain Ischemia; Caspase 3; Caspase Inhibitors; Cell Count; Cell Death; Cyclic AMP-Dependent Protein Kinases; Dexmedetomidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Glucose; Hippocampus; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Hypoxia; Ischemic Preconditioning; Male; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrosine | 2005 |
Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: a possible mechanism for its neuroprotective activity.
Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Brain Ischemia; Carbon Dioxide; Carbon Radioisotopes; Cells, Cultured; Cerebral Cortex; Dexmedetomidine; Glutamic Acid; Glutamine; Hypoxia, Brain; Mice; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction | 2000 |
Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Brain Chemistry; Brain Ischemia; Catecholamines; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Dexmedetomidine; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2002 |