Page last updated: 2024-08-24

dexmedetomidine and Blood Poisoning

dexmedetomidine has been researched along with Blood Poisoning in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (10.81)	29.6817
2010's	40 (54.05)	24.3611
2020's	26 (35.14)	2.80

Authors

Authors	Studies
Liao, P; Liu, Z; Yang, B; Zeng, Y	1
Deng, S; Gong, Y; Jin, P; Lenahan, C; Tan, J; Tian, M; Wang, K; Wang, W; Wang, Y; Wen, H; Zhao, F	1
Hu, C; Hu, J; Li, J; Li, Y; Lian, Q; Ma, D; Wu, B	1
Ambrósio, AM; de Olveira, CM; Fantoni, DT; Gonçalves, LA; Nagashima, JK; Pereira, MA; Talib, MS	1
An, S; Chen, Z; Hu, H; Jin, Y; Li, L; Sha, T; Wu, F; Wu, J; Zeng, Z	1
Auler-Jr, JOC; Carnicelli, P; Fantoni, DT; Ida, KK; Kahvegian, MAP; Monteiro Filho, A; Otsuki, DA; Rouby, JJ	1
Anstey, C; Bailey, M; Fraser, JF; Moore, JPR; Murray, L; Reade, MC; Shehabi, Y; Singer, M	1
Gong, C; Huang, Y; Liu, X; Tang, Y; Wang, D; Xiong, J; Zhang, Q	1
Chen, L; Li, M; Li, Y; Liang, M; Lin, Y; Zeng, K	1
Aidoni, Z; Foroulis, CN; Grosomanidis, V; Kazakos, G; Kotzampassi, K; Pourzitaki, C; Skourtis, C; Stamoula, E; Tsaousi, G; Vasilakos, DG	1
Ao, X; Chen, DD; Deng, C; Li, JH; Liu, L; Wu, SZ; Zi, SF	1
Bailey, SR; Bellomo, R; Evans, RG; Farmer, DGS; Hood, SG; Iguchi, N; Lankadeva, YR; Ma, S; May, CN	1
Gao, M; Liu, D; Liu, Y; Song, F; Yang, P; Yu, T; Zhang, M; Zhang, X	1
Liu, Y; Wang, C; Yu, Y; Zhang, J	1
Chen, X; Gao, S; Ji, H; Yin, L	1
Huang, Q; Kong, Q; Qiu, Z; Song, X; Wu, X; Xia, Z	1
Chen, J; Qiu, J; Wang, R; Xie, Y	1
Chen, P; Hu, B; Jiang, J; Levy, MM; Li, G; Qiu, Z; Zhang, Y	1
Chen, X; Li, C; Liu, Y; Shao, Y; Wang, L; Zhao, W	1
Hu, A; Li, Y; Lin, J; Wang, C; Xia, Z; Yang, CF; Yuan, W; Zhang, Z	1
He, J; Kang, L; Ni, J; Wang, L; Yin, S; Zhong, Z	1
Ding, L; Gao, X; Sheng, L; Yu, S	1
Lu, Y; Zhu, S	1
Aso, S; Fushimi, K; Matsui, H; Yasunaga, H	1
Kawazoe, Y; Miyamoto, K; Morimoto, T; Ohta, Y; Yamamura, H	1
Li, J; Mei, B; Zuo, Z	1
Gao, Y; Han, QY; Huang, R; Kang, K; Kong, WL; Li, JY; Li, M; Li, NN; Liu, HT; Liu, RJ; Liu, YS; Qi, ZD; Wang, HL; Wang, SC; Yang, ZY; Yu, KJ; Zhang, WH; Zhang, X; Zhao, MY; Zheng, JB	1
Bellomo, R; Deane, AM; Lankadeva, YR; May, CN; Plummer, MP; Shehabi, Y	1
Anzueto, A; Bernard, GR; Brummel, NE; Bui, LN; Devlin, JW; Dittus, RS; Duprey, MS; Ely, EW; Girard, TD; Gropper, MA; Guntupalli, KK; Hoskins, AS; Hughes, CG; Jackson, JC; Kiehl, AL; Mailloux, PT; O'Neal, HR; Orun, OM; Pandharipande, PP; Patel, MB; Pun, BT; Raman, R; Sanders, RD; Snyder, A; Stashenko, GJ; Stollings, JL; Swan, JT	1
Ma, S; Ma, X; Yang, H; Zhou, W	1
Al-Bassam, W; Bellomo, R; James, A; Murfin, B; Shehabi, Y	1
Beppu, S; Fuke, A; Hashimoto, A; Itoh, M; Katayama, Y; Kawazoe, Y; Koami, H; Miyamoto, K; Morimoto, T; Ohta, Y; Yamamoto, T; Yamamura, H	1
Kuhn, SO; Rehberg, S; Scheer, CS	1
Kawazoe, Y; Morimoto, T; Yamamura, H	1
Amigoni, A; Blangetti, I; Casella, G; Chelazzi, C; Conti, G; Forfori, F; Garisto, C; Moltrasio, M; Mondardini, MC; Pasero, D; Principi, T; Ricci, Z; Romagnoli, S; Tarantino, F	1
Cheng, Z; Feng, J; Li, A; Qian, H; Wu, Y; Xiao, H; Yan, F; Yang, Q; Zhang, X; Zhao, Z	1
Gao, X; Hei, Z; Huang, P; Ji, H; Qiu, R; Sha, W; Wang, F; Yao, W; Yuan, D	1
Cai, JQ; Cao, CC; Guo, RJ; Jia, L; Xu, WX; Xue, X; Yang, HJ; Zhao, W	1
Gao, Y; Huang, R; Kang, K; Kong, WL; Liu, HT; Liu, RJ; Liu, YS; Qi, ZD; Qu, JD; Wang, HL; Wang, SC; Yu, KJ; Zhang, X; Zheng, JB	1
Gromov, MS; Maslyakov, VV; Zabrodskii, PF	1
Alam, A; Cui, J; Ma, D; Mu, DL; Sun, YB; Wang, DX; Wu, L; Zhang, W; Zhao, H	1
Liang, FQ; Lin, Q; Xie, T; Zhang, JR	1
Xu, P; Yang, W; Zhan, XH; Zhang, WQ; Zheng, P	1
Aidoni, Z; Dardalas, I; Grosomanidis, V; Kouvelas, D; Malliou, F; Milonas, A; Papazisis, G; Pourzitaki, C; Rigopoulos, P; Stamoula, E; Tsaousi, G	1
Chen, H; Jiang, XQ; Jin, YH; Li, ZT; Wu, F; Zhang, YY	1
Bi, L; Jia, Z; Li, XK; Yang, SC	1
Bao, H; Si, Y; Wang, X; Xu, L	1
Akkuş, M; Altekin, E; Cilaker Mıcılı, S; Duru, S; Ergür, BU; Girgin, P; Gündüz, K; Güzeldağ, S; Koca, U; Olguner, ÇG; Taşdöğen, A	1
Fleming, N; Ji, F; Li, Z; Liu, H; Nguyen, H; Shi, P; Young, N	1
Huang, H; Huang, L; Li, X; Liu, Y; Lu, F; Wu, Y; Zhang, Y; Zhou, C; Zhu, Y	1
Balarini, MM; Bouskela, E; Miranda, ML	1
Li, H; Wang, Y; Wang, Z; Zhang, J; Zhou, G	1
Li, ST; Wu, J	1
Li, J; Li, X	1
Chen, YJ; Gong, CL; Tan, F; Zhou, SL	1
Chen, JH; Jin, SY; Lei, DX; Song, XR; Yu, GF; Zhang, WH; Zhou, SL	1
Bahrami, A; Fakhri-Bafghi, MS; Hirbod-Mobarakeh, A; Keshavarz-Fathi, M; Nader, ND; Rezaei, N; Zamani, MM	1
Gong, C; Jing, G; Liu, Z; Ning, Q; Wang, Q; Wang, Y; Zhang, Y; Zhao, W	1
Rudiger, A; Singer, M	1
Jiang, L; Li, ZJ; Ran, K; Wang, D; Zhang, SB; Zhang, Y	1
Bissell, BD; Ferreira, JA	1
Han, F; Liu, Z; Ning, Q; Sun, H; Wang, X; Yang, M; Zhang, J; Zhang, R; Zhang, X; Zhao, W	1
Larson, JS; Patel, BM; Rady, MY	1
DePriest, J; Gonzalez, L	1
Gupta, A; Lee, D; Su, M	1
Paciullo, C	1
Ma, D; Maze, M; Qiao, H; Sanders, RD; Wu, X	1
Memis, D; Sut, N; Tasdogan, M; Yuksel, M	1
MacLaren, R	1
Ely, EW; Girard, TD; Herr, DL; Maze, M; McGrane, S; Pandharipande, PP; Sanders, RD; Shintani, AK; Thompson, JL	1
Memiş, D; Sezer, A; Süt, N; Usta, U	1
Kress, JP	1
Quintin, L	1
Hekimoğlu, S; Memiş, D; Süt, N; Vatan, I; Yandim, T; Yüksel, M	1

Reviews

9 review(s) available for dexmedetomidine and Blood Poisoning

Article	Year
Efficacy and safety of dexmedetomidine in sepsis patients requiring mechanical ventilation: a systematic review and meta-analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:3 Topics: Dexmedetomidine; Humans; Intensive Care Units; Length of Stay; Respiration, Artificial; Sepsis	2022
Effect of Dexmedetomidine on duration of mechanical ventilation in septic patients: a systematic review and meta-analysis. BMC pulmonary medicine, 2020, Feb-17, Volume: 20, Issue:1 Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Randomized Controlled Trials as Topic; Respiration, Artificial; Sepsis; Treatment Outcome; Ventilator Weaning	2020
Emerging benefits and drawbacks of α British journal of pharmacology, 2021, Volume: 178, Issue:6 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Clonidine; Critical Illness; Dexmedetomidine; Humans; Receptors, Adrenergic, alpha-2; Sepsis	2021
Light sedation with dexmedetomidine: a practical approach for the intensivist in different ICU patients. Minerva anestesiologica, 2018, Volume: 84, Issue:6 Topics: Acute Disease; Adult; Cardiac Surgical Procedures; Cerebrovascular Disorders; Child; Conscious Sedation; Critical Care; Critical Illness; Deep Sedation; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Sepsis	2018
Efficacy of dexmedetomidine for treatment of patients with sepsis: A meta-analysis of randomized controlled trials. Medicine, 2019, Volume: 98, Issue:18 Topics: Aged; Dexmedetomidine; Female; Hospital Mortality; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Prognosis; Randomized Controlled Trials as Topic; Respiration, Artificial; Sepsis	2019
Dexmedetomidine effects in different experimental sepsis in vivo models. European journal of pharmacology, 2019, Aug-05, Volume: 856 Topics: Animals; Dexmedetomidine; Disease Models, Animal; Humans; Organ Specificity; Sepsis	2019
Dexmedetomidine May Produce Extra Protective Effects on Sepsis-induced Diaphragm Injury. Chinese medical journal, 2015, May-20, Volume: 128, Issue:10 Topics: Dexmedetomidine; Diaphragm; Humans; Sepsis	2015
Survival benefits of dexmedetomidine used for sedating septic patients in intensive care setting: A systematic review. Journal of critical care, 2016, Volume: 32 Topics: Adolescent; Adult; Aged; Critical Care; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Randomized Controlled Trials as Topic; Sepsis; Treatment Outcome; Young Adult	2016
Misdirected Sympathy: The Role of Sympatholysis in Sepsis and Septic Shock. Journal of intensive care medicine, 2018, Volume: 33, Issue:2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Animals; Catecholamines; Clonidine; Dexmedetomidine; Humans; Propanolamines; Sepsis; Shock, Septic; Stroke Volume; Sympathetic Nervous System; Sympatholytics; Tachycardia	2018

Trials

9 trial(s) available for dexmedetomidine and Blood Poisoning

Article	Year
Microcirculation assessment of dexmedetomidine constant rate infusion during anesthesia of dogs with sepsis from pyometra: a randomized clinical study. Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:6 Topics: Anesthesia; Anesthetics, Inhalation; Animals; Dexmedetomidine; Dog Diseases; Dogs; Female; Fentanyl; Isoflurane; Lactates; Microcirculation; Pyometra; Sepsis	2022
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients. Critical care (London, England), 2022, 11-22, Volume: 26, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Conscious Sedation; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Propofol; Prospective Studies; Respiration, Artificial; Sepsis	2022
Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial. Critical care (London, England), 2020, 08-10, Volume: 24, Issue:1 Topics: Aged; C-Reactive Protein; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Inflammation; Male; Middle Aged; Procalcitonin; Respiration, Artificial; Sepsis; Treatment Outcome	2020
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. The New England journal of medicine, 2021, 04-15, Volume: 384, Issue:15 Topics: Adult; Cognition; Conscious Sedation; Critical Illness; Dexmedetomidine; Double-Blind Method; Humans; Hypnotics and Sedatives; Kaplan-Meier Estimate; Propofol; Respiration, Artificial; Sepsis	2021
Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial. JAMA, 2017, 04-04, Volume: 317, Issue:13 Topics: Aged; Aged, 80 and over; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Male; Middle Aged; Respiration, Artificial; Sepsis; Survival Analysis; Treatment Outcome; Ventilator Weaning	2017
Perioperative dexmedetomidine improves outcomes of cardiac surgery. Circulation, 2013, Apr-16, Volume: 127, Issue:15 Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aged; Cardiac Surgical Procedures; Catecholamines; Delirium; Dexmedetomidine; Female; Heart Diseases; Hospital Mortality; Hospital Records; Humans; Hypnotics and Sedatives; Length of Stay; Male; Middle Aged; Myocardial Ischemia; Patient Readmission; Perioperative Care; Postoperative Complications; Respiration, Artificial; Retrospective Studies; Sepsis; Stroke; Treatment Outcome	2013
Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. Journal of clinical anesthesia, 2009, Volume: 21, Issue:6 Topics: Abdomen; Adrenergic alpha-Agonists; Adult; Aged; Dexmedetomidine; Female; Hospitals, University; Humans; Hypnotics and Sedatives; Inflammation; Infusions, Intravenous; Interleukin-1; Interleukin-6; Male; Middle Aged; Pilot Projects; Pressure; Propofol; Prospective Studies; Respiration, Artificial; Sepsis; Severity of Illness Index; Tumor Necrosis Factor-alpha; Young Adult	2009
Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Critical care (London, England), 2010, Volume: 14, Issue:2 Topics: Adult; Aged; Coma; Delirium; Dexmedetomidine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Lorazepam; Male; Middle Aged; Outcome Assessment, Health Care; Respiration, Artificial; Sepsis	2010
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. British journal of anaesthesia, 2007, Volume: 98, Issue:4 Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Inflammation Mediators; Midazolam; Sepsis	2007

Other Studies

56 other study(ies) available for dexmedetomidine and Blood Poisoning

Article	Year
Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1/Th2/Th17 polarization in an experimental sepsis model of mice. International immunopharmacology, 2021, Volume: 101, Issue:Pt B Topics: Animals; Blood-Brain Barrier; Cecum; Cognitive Dysfunction; Cytokines; Dexmedetomidine; Hippocampus; Inflammation; Male; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Sepsis; Th17 Cells	2021
The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats. European journal of pharmacology, 2022, Jan-05, Volume: 914 Topics: Acetylcholine; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Catecholamines; Dexmedetomidine; Interleukin-1beta; Lung; Protective Agents; Rats; Rats, Sprague-Dawley; Sepsis; Treatment Outcome; Tumor Necrosis Factor-alpha; Vagotomy; Vagus Nerve	2022
Association between dexmedetomidine administration and outcomes in critically ill patients with sepsis-associated acute kidney injury. Journal of clinical anesthesia, 2022, Volume: 83 Topics: Acute Kidney Injury; Cohort Studies; Critical Illness; Dexmedetomidine; Humans; Intensive Care Units; Retrospective Studies; Sepsis	2022
Effects of dexmedetomidine on hemodynamic, oxygenation, microcirculation, and inflammatory markers in a porcine model of sepsis. Acta cirurgica brasileira, 2022, Volume: 37, Issue:7 Topics: Animals; Dexmedetomidine; Hemodynamics; Microcirculation; Oxygen; Sepsis; Shock, Septic; Swine	2022
Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis. Immunity, inflammation and disease, 2023, Volume: 11, Issue:6 Topics: Animals; Cytokines; Dexmedetomidine; Inflammation; Lipopolysaccharides; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Sepsis; Tumor Necrosis Factor-alpha	2023
Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats. International immunopharmacology, 2023, Volume: 122 Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Interleukin-6; Kidney; Leukocyte Elastase; Lipocalin-2; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha	2023
Circulatory effects of dexmedetomidine in early sepsis: a randomised controlled experimental study. Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Escherichia coli Infections; Hemodynamics; Male; Sepsis; Swine; Swine Diseases	2020
Dexmedetomidine-mediated protection against septic liver injury depends on TLR4/MyD88/NF-κB signaling downregulation partly via cholinergic anti-inflammatory mechanisms. International immunopharmacology, 2019, Volume: 76 Topics: Animals; Anti-Inflammatory Agents; Dexmedetomidine; Down-Regulation; Interleukin-6; Lipopolysaccharides; Liver; Liver Diseases; Male; Myeloid Differentiation Factor 88; NF-kappa B; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Vagus Nerve	2019
Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury. Kidney international, 2019, Volume: 96, Issue:5 Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cytokines; Dexmedetomidine; Drug Evaluation, Preclinical; Escherichia coli; Hemodynamics; Kidney; Norepinephrine; Oxygen; Sepsis; Sheep	2019
Dexmedetomidine prevents septic myocardial dysfunction in rats via activation of α7nAChR and PI3K/Akt- mediated autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line; Cytokines; Dexmedetomidine; Disease Models, Animal; Heart Diseases; Inflammation Mediators; Male; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats, Wistar; Sepsis; Signal Transduction; Ventricular Function, Left	2019
The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice. Life sciences, 2019, Dec-15, Volume: 239 Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cytokines; Dexmedetomidine; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Protective Agents; Renal Insufficiency; Retinoblastoma-Binding Protein 2; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha	2019
Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90/AKT signaling. Molecular medicine reports, 2019, Volume: 20, Issue:5 Topics: Animals; Cell Survival; Dexmedetomidine; HSP90 Heat-Shock Proteins; Male; Neurons; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sepsis; Sepsis-Associated Encephalopathy; Signal Transduction	2019
Protective Effect of Dexmedetomidine on Acute Lung Injury via the Upregulation of Tumour Necrosis Factor-α-Induced Protein-8-like 2 in Septic Mice. Inflammation, 2020, Volume: 43, Issue:3 Topics: Acute Lung Injury; Administration, Intravenous; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Gene Transfer Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Random Allocation; Sepsis; Treatment Outcome; Up-Regulation	2020
The Effects of Dexmedetomidine in a Rat Model of Sepsis-Induced Lung Injury are Mediated Through the Adenosine Monophosphate-Activated Protein Kinase (AMPK)/Silent Information Regulator 1 (SIRT1) Pathway. Medical science monitor : international medical journal of experimental and clinical research, 2020, Feb-08, Volume: 26 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Body Temperature; Cytokines; Dexmedetomidine; Disease Models, Animal; Inflammation Mediators; Lung; Lung Injury; Male; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Sirtuin 1; Survival Analysis	2020
Dexmedetomidine alleviates lung injury in sepsis mice through regulating P38 MAPK signaling pathway. Panminerva medica, 2021, Volume: 63, Issue:4 Topics: Animals; Dexmedetomidine; Humans; Lung; Lung Injury; Mice; p38 Mitogen-Activated Protein Kinases; Sepsis; Signal Transduction	2021
Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury. Molecular medicine reports, 2020, Volume: 22, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Ferroptosis; Heart; Heart Injuries; Male; Mice, Inbred C57BL; Myocardium; Sepsis	2020
Effects of dexmedetomidine pretreatment on rats with sepsis-induced acute kidney injury and miR-146a expression. Cellular and molecular biology (Noisy-le-Grand, France), 2020, May-15, Volume: 66, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Catalase; Creatinine; Dexmedetomidine; Heme Oxygenase (Decyclizing); Interleukin-1beta; Interleukin-6; Kidney; Lipopolysaccharides; Malondialdehyde; MicroRNAs; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sepsis; Superoxide Dismutase	2020
miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14. Journal of bioenergetics and biomembranes, 2020, Volume: 52, Issue:4 Topics: Acute Lung Injury; Analgesics, Non-Narcotic; Animals; Dexmedetomidine; Male; Mice; MicroRNAs; Mitogen-Activated Protein Kinase 14; Sepsis	2020
Dexmedetomidine Suppressed the Biological Behavior of HK-2 Cells Treated with LPS by Down-Regulating ALKBH5. Inflammation, 2020, Volume: 43, Issue:6 Topics: AlkB Homolog 5, RNA Demethylase; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dexmedetomidine; Down-Regulation; Epigenesis, Genetic; Humans; Immunoprecipitation; In Vitro Techniques; Inflammation; Lipopolysaccharides; NF-kappa B; RNA, Long Noncoding; Sepsis; Signal Transduction	2020
Dexmedetomidine and Mortality From Sepsis Requiring Mechanical Ventilation: A Japanese Nationwide Retrospective Cohort Study. Journal of intensive care medicine, 2021, Volume: 36, Issue:9 Topics: Adult; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Japan; Propofol; Respiration, Artificial; Retrospective Studies; Sepsis	2021
Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor. Brain, behavior, and immunity, 2021, Volume: 91 Topics: Animals; Brain Diseases; Dexmedetomidine; Inflammation; Male; Mice; Receptors, Adrenergic; Sepsis	2021
Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway. Inflammation, 2021, Volume: 44, Issue:2 Topics: Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Blotting, Western; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labeling; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Random Allocation; Sepsis; Signal Transduction; Spleen; Splenectomy	2021
[Effect of dexmedetomidine on expression of tight junction protein ZO-1 in kidney tissue of rats with acute kidney injury induced by sepsis]. Zhonghua wei zhong bing ji jiu yi xue, 2020, Volume: 32, Issue:12 Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Kidney; Male; Rats; Rats, Sprague-Dawley; Sepsis; Zonula Occludens-1 Protein	2020
Trials of dexmedetomidine sedation in ventilated critically ill septic patients: Challenges, limitations and opportunities. Anaesthesia, critical care & pain medicine, 2021, Volume: 40, Issue:4 Topics: Conscious Sedation; Critical Illness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Sepsis	2021
Dexmedetomidine in Patients With Sepsis Requiring Mechanical Ventilation. JAMA, 2017, 08-01, Volume: 318, Issue:5 Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Respiration, Artificial; Sepsis	2017
Dexmedetomidine in Patients With Sepsis Requiring Mechanical Ventilation-Reply. JAMA, 2017, 08-01, Volume: 318, Issue:5 Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Respiration, Artificial; Sepsis	2017
Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-κB pathway. PloS one, 2018, Volume: 13, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Gene Expression Regulation; Hippocampus; Injections, Intraperitoneal; Interleukin-6; Lipopolysaccharides; Neuroprotective Agents; NF-kappa B; Proline; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha	2018
Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model. Life sciences, 2018, Jul-01, Volume: 204 Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cecal Diseases; Cecum; Cytokines; Dexmedetomidine; Imidazoles; Inflammation; Kidney; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sepsis; Toll-Like Receptor 4	2018
Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103 Topics: Acute Lung Injury; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Immune System; Inflammation; Ki-67 Antigen; NF-kappa B; Protective Agents; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Taurine	2018
Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106 Topics: Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Inflammation Mediators; Kidney Tubules; Lipopolysaccharides; Male; Mice, Inbred C57BL; Sepsis; Signal Transduction; Time Factors	2018
Combined Effect of NF-κB Inhibitor and β2-Adrenoreceptor Agonist on Mouse Mortality and Blood Concentration of Proinflammatory Cytokines in Sepsis. Bulletin of experimental biology and medicine, 2018, Volume: 165, Issue:4 Topics: Adrenergic beta-Agonists; Animals; Cytokines; Dexmedetomidine; Female; Male; Mice; NF-kappa B; Nitriles; Sepsis; Signal Transduction; Sulfones	2018
Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis. Cell death & disease, 2019, 02-18, Volume: 10, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Astrocytes; Brain; Cytokines; Dexmedetomidine; Disease Models, Animal; Histones; Humans; Inflammasomes; Lipopolysaccharides; Male; Neuroglia; Neurons; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; PC12 Cells; Pyroptosis; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha	2019
Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption. Medical science monitor : international medical journal of experimental and clinical research, 2019, Mar-11, Volume: 25 Topics: Acute Lung Injury; Animals; Apoptosis; Dexmedetomidine; Lung; Male; Mice; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Oxidative Stress; Oxygen Consumption; Respiratory Function Tests; Sepsis	2019
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:11 Topics: Acute Kidney Injury; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Humans; Kidney; Lipopolysaccharides; Male; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Sepsis; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4	2019
Effects of dexmedetomidine on sepsis-induced liver injury in rats. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:3 Suppl Topics: Animals; Dexmedetomidine; Disease Models, Animal; Lipopolysaccharides; Liver Diseases; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis; Survival Analysis; Treatment Outcome	2019
Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013, Volume: 62, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Cecum; Cytokines; Dexmedetomidine; HMGB1 Protein; Ligation; Lung; Male; Mice; Mice, Inbred BALB C; RNA, Messenger; Sepsis	2013
The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis. TheScientificWorldJournal, 2013, Volume: 2013 Topics: Acute Kidney Injury; Acute Lung Injury; Acute-Phase Proteins; Animals; Apoptosis; Caspase 3; Cecum; Cell Count; Creatinine; Dexmedetomidine; Disease Models, Animal; DNA Fragmentation; Kidney; Lipocalin-2; Lipocalins; Lung; Macrophages, Alveolar; Male; Malondialdehyde; Proto-Oncogene Proteins; Rats; Rats, Wistar; Sepsis	2013
Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway. Mediators of inflammation, 2013, Volume: 2013 Topics: Animals; Blotting, Western; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Interleukin-6; Lung; NF-kappa B; Rats; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha	2013
Dexmedetomidine attenuates the microcirculatory derangements evoked by experimental sepsis. Anesthesiology, 2015, Volume: 122, Issue:3 Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blood Flow Velocity; Cricetinae; Dexmedetomidine; Male; Mesocricetus; Microcirculation; Sepsis	2015
The effect of dexmedetomidine on inflammatory response of septic rats. BMC anesthesiology, 2015, May-01, Volume: 15 Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Inflammation; Interleukin-6; Ligation; Male; MAP Kinase Signaling System; Myeloid Differentiation Factor 88; NF-kappa B; Random Allocation; Rats, Sprague-Dawley; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Yohimbine	2015
[Effect of dexmedetomidine on high-mobility group box 1 protein in rats with sepsis]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2015, Volume: 40, Issue:9 Topics: Animals; Dexmedetomidine; HMGB1 Protein; Lipopolysaccharides; Male; Rats; Rats, Wistar; Sepsis; Spleen; Tumor Necrosis Factor-alpha	2015
[Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:10 Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Inflammation; Interleukin-1beta; Kidney; Lipopolysaccharides; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sepsis; Superoxide Dismutase	2015
Activation of α2 adrenoceptor attenuates lipopolysaccharide-induced hepatic injury. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:9 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Interleukin-1beta; Interleukin-6; Lactic Acid; Lipopolysaccharides; Liver; Male; Malondialdehyde; Oxidative Stress; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Sepsis; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha; Yohimbine	2015
Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway. International immunopharmacology, 2016, Volume: 35 Topics: Adrenergic alpha-2 Receptor Agonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bungarotoxins; Dexmedetomidine; Interleukin-6; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Pneumonia; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha	2016
Decatecholaminisation during sepsis. Critical care (London, England), 2016, 10-04, Volume: 20, Issue:1 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-1 Receptor Antagonists; Catecholamines; Dexmedetomidine; Humans; Norepinephrine; Propanolamines; Sepsis	2016
Dexmedetomidine may upregulate the expression of caveolin‑1 in lung tissues of rats with sepsis and improve the short‑term outcome. Molecular medicine reports, 2017, Volume: 15, Issue:2 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Gas Analysis; Body Temperature; Caveolin 1; Dexmedetomidine; Disease Models, Animal; Hypnotics and Sedatives; Imidazoles; Lung; Male; Rats; Rats, Sprague-Dawley; Sepsis; Toll-Like Receptor 4; Up-Regulation	2017
Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice. Neurological research, 2017, Volume: 39, Issue:4 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Brain Diseases; Dexmedetomidine; Disease Models, Animal; Interleukin-1beta; Lipopolysaccharides; Male; Malondialdehyde; Mice, Inbred BALB C; Neurodegenerative Diseases; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Reactive Oxygen Species; Sepsis; Tumor Necrosis Factor-alpha	2017
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA, 2009, Jun-17, Volume: 301, Issue:23 Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Respiration, Artificial; Sepsis	2009
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA, 2009, Jun-17, Volume: 301, Issue:23 Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Respiration, Artificial; Sepsis	2009
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA, 2009, Jun-17, Volume: 301, Issue:23 Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Respiration, Artificial; Sepsis; Substance Withdrawal Syndrome	2009
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU. JAMA, 2009, Jun-17, Volume: 301, Issue:23 Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Humans; Hypnotics and Sedatives; Intensive Care Units; Midazolam; Respiration, Artificial; Sepsis	2009
Sedation improves early outcome in severely septic Sprague Dawley rats. Critical care (London, England), 2009, Volume: 13, Issue:4 Topics: Animals; Blotting, Western; Caspase 3; Dexmedetomidine; Hypnotics and Sedatives; Interleukin-6; Male; Midazolam; Rats; Rats, Sprague-Dawley; Sepsis; Severity of Illness Index; Signal Transduction; Spleen; Treatment Outcome; Tumor Necrosis Factor-alpha	2009
Immunosedation: a consideration for sepsis. Critical care (London, England), 2009, Volume: 13, Issue:5 Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Immune System; Midazolam; Sepsis	2009
The effect of dexmedetomidine on liver histopathology in a rat sepsis model: an experimental pilot study. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2010, Volume: 16, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Dexmedetomidine; Endotoxemia; Endotoxins; Escherichia coli; Female; Inflammation; Lipopolysaccharides; Liver; Rats; Rats, Wistar; Sepsis	2010
The complex interplay between delirium, sepsis and sedation. Critical care (London, England), 2010, Volume: 14, Issue:3 Topics: Brain; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Lorazepam; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Respiration, Artificial; Sepsis	2010
Alpha-2 adrenoceptor agonists and sepsis: improved survival? Critical care (London, England), 2010, Volume: 14, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Fentanyl; Humans; Sepsis; Survival Analysis	2010