Page last updated: 2024-08-24

dexmedetomidine and Aging

dexmedetomidine has been researched along with Aging in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (31.58)29.6817
2010's12 (63.16)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Cao, Y; Wang, M; Wang, S; Wu, Y; Xu, X1
Fu, Q; Liu, J; Wang, JH; Wang, PQ; Xu, ZP; Zhang, H; Zhou, XY1
Dong, J; Guo, X; Li, L; Yang, S1
Huang, H; Li, L; Li, P; Li, Z; Xu, B; Zhou, D1
Chen, N; Chen, X; Qian, J; Wu, C; Xie, J1
Han, L; Jiang, JH; Liu, MZ; Peng, YM; Qian, XL; Wang, QD; Zhang, JM; Zhang, W; Zhou, YB1
Fels, RJ; Kenney, MJ; McMurphy, RM1
Adachi, T; Fujisawa, S; Hongo, M; Ohba, T; Ono, K; Shibata, S; Shimbo, T1
Aoyama, B; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M1
Dinardo, JA; Fontaine, PJ; Mason, KP; Prescilla, R; Zgleszewski, S; Zurakowski, D1
Adamson, PC; Barrett, JS; Gastonguay, MR; Godinez, RI; Kang, DS; Nicolson, SC; Su, F; Zuppa, AF1
Crecelius, AR; Dinenno, FA; Kirby, BS; Voyles, WF1
Aantaa, R; Ihmsen, H; Iirola, T; Kentala, E; Kurvinen, JP; Laitio, R; Olkkola, KT; Scheinin, M; Schüttler, J; Schwilden, H1
Brandes, V; Ibacache, ME; Morales, AL; Muñoz, HR1
Aliabadi, FS; Bettschart-Wolfensberger, R; Bowen, IM; Clarke, KW; Freeman, SL; Huhtinen, M; Weller, R1
Dinenno, FA; Kirby, BS; Markwald, RR; Smith, EG; Voyles, WF1
Donato, AJ1
Aantaa, R; Kaisti, K; Manner, T; Olkkola, KT; Rautiainen, P; Scheinin, M; Vilo, S1
Björklund, M; Heikkinen, T; Riekkinen, P; Sallinen, J; Scheinin, M; Siverina, I; Tanila, H1

Trials

2 trial(s) available for dexmedetomidine and Aging

ArticleYear
Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients.
    British journal of anaesthesia, 2012, Volume: 108, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Conscious Sedation; Critical Care; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Hemodynamics; Humans; Hypnotics and Sedatives; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Respiration, Artificial; Young Adult

2012
Single-dose dexmedetomidine reduces agitation after sevoflurane anesthesia in children.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Dexmedetomidine; Female; Heart Rate; Hernia, Inguinal; Humans; Hypnotics and Sedatives; Infant; Male; Methyl Ethers; Prospective Studies; Psychomotor Agitation; Sevoflurane; Sex Characteristics

2004

Other Studies

17 other study(ies) available for dexmedetomidine and Aging

ArticleYear
Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.
    Folia neuropathologica, 2019, Volume: 57, Issue:4

    Topics: Aging; Animals; Benzylisoquinolines; Brain; Dexmedetomidine; Inflammasomes; Inflammation; Male; Mitochondria; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species

2019
Dexmedetomidine ameliorates postoperative cognitive dysfunction by inhibiting Toll-like receptor 4 signaling in aged mice.
    The Kaohsiung journal of medical sciences, 2020, Volume: 36, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Cell Line; Dexmedetomidine; Gene Expression Regulation; Hepatectomy; Hippocampus; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; Postoperative Cognitive Complications; Signal Transduction; Spatial Memory; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2020
The effects of dexmedetomidine preconditioning on aged rat heart of ischaemia reperfusion injury.
    Research in veterinary science, 2017, Volume: 114

    Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Dexmedetomidine; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley

2017
The Influence of Age on Sensitivity to Dexmedetomidine Sedation During Spinal Anesthesia in Lower Limb Orthopedic Surgery.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Anesthesia, Spinal; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Lower Extremity; Male; Middle Aged; Orthopedic Procedures; Young Adult

2017
Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation.
    Molecular medicine reports, 2019, Volume: 20, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Animals; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Inflammation; Interleukin-1beta; Male; Postoperative Cognitive Complications; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2019
Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice.
    European journal of pharmacology, 2015, Jan-05, Volume: 746

    Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Anesthetics, General; Animals; Apoptosis; Apoptosis Regulatory Proteins; Behavior, Animal; Cognition Disorders; Dexmedetomidine; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Maze Learning; Mice, Inbred BALB C; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Postoperative Complications; Random Allocation; Splenectomy

2015
Dexmedetomidine and regulation of splenic sympathetic nerve discharge in aged F344 rats.
    Autonomic neuroscience : basic & clinical, 2015, Volume: 190

    Topics: Aging; Animals; Blood Pressure; Dexmedetomidine; Heart Rate; Hypnotics and Sedatives; Male; Rats, Inbred F344; Spleen; Sympathetic Nervous System

2015
Age-related effects of dexmedetomidine on myocardial contraction and coronary circulation in isolated guinea pig hearts.
    Journal of pharmacological sciences, 2016, Volume: 131, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Aging; Analgesics, Non-Narcotic; Animals; Coronary Circulation; Coronary Vessels; Dexmedetomidine; Guinea Pigs; Heart; Heart Rate; Hypnotics and Sedatives; In Vitro Techniques; Myocardial Contraction; Ventricular Function, Left

2016
Preventive effects of dexmedetomidine on the development of cognitive dysfunction following systemic inflammation in aged rats.
    Journal of anesthesia, 2017, Volume: 31, Issue:1

    Topics: Aging; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Hypnotics and Sedatives; Imidazoles; Inflammation; Isoindoles; Isoquinolines; Lipopolysaccharides; Male; Memory Disorders; Neuroprotective Agents; Piperazines; Rats; Signal Transduction

2017
Incidence and predictors of hypertension during high-dose dexmedetomidine sedation for pediatric MRI.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:6

    Topics: Adolescent; Aging; Blood Pressure; Child; Child, Preschool; Cohort Studies; Conscious Sedation; Databases, Factual; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Hypnotics and Sedatives; Infant; Infant, Newborn; Infusions, Intravenous; Magnetic Resonance Imaging; Male; Predictive Value of Tests; Quality Assurance, Health Care; Risk Factors

2010
Population pharmacokinetics of dexmedetomidine in infants after open heart surgery.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Aging; Algorithms; Cardiac Surgical Procedures; Cohort Studies; Computer Simulation; Critical Illness; Dexmedetomidine; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Defects, Congenital; Humans; Hypnotics and Sedatives; Infant; Linear Models; Male; Models, Statistical; Nonlinear Dynamics; Population; Predictive Value of Tests; Safety

2010
Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans.
    The Journal of physiology, 2011, May-15, Volume: 589, Issue:Pt 10

    Topics: Adenosine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Aged; Aging; Dexmedetomidine; Exercise; Female; Forearm; Hand Strength; Humans; Hyperemia; Male; Middle Aged; Muscle Contraction; Muscle, Skeletal; Phenylephrine; Ultrasonography, Doppler; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Young Adult

2011
Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies.
    Equine veterinary journal, 2005, Volume: 37, Issue:1

    Topics: Aging; Analysis of Variance; Animals; Area Under Curve; Blood Pressure; Cardiovascular System; Dexmedetomidine; Heart Rate; Horses; Hypnotics and Sedatives; Infusions, Intravenous; Partial Pressure; Respiration

2005
Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men.
    The Journal of physiology, 2007, Jul-01, Volume: 582, Issue:Pt 1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Aging; Blood Flow Velocity; Dexmedetomidine; Dose-Response Relationship, Drug; Femoral Artery; Humans; Laser-Doppler Flowmetry; Leg; Male; Middle Aged; Norepinephrine; Phenylephrine; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reference Values; Research Design; Sympathetic Nervous System; Tyramine; Vasoconstriction; Vasoconstrictor Agents

2007
Ageing and vascular adrenoceptor desensitization: too little, too late?
    The Journal of physiology, 2007, Jul-01, Volume: 582, Issue:Pt 1

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Aging; Blood Flow Velocity; Dexmedetomidine; Femoral Artery; Humans; Leg; Male; Middle Aged; Norepinephrine; Phenylephrine; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reference Values; Sympathetic Nervous System; Tyramine; Vasoconstriction; Vasoconstrictor Agents

2007
Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age.
    British journal of anaesthesia, 2008, Volume: 100, Issue:5

    Topics: Adrenergic alpha-Agonists; Aging; Bronchoscopy; Child; Child, Preschool; Conscious Sedation; Dexmedetomidine; Drug Evaluation; Female; Half-Life; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male

2008
Spatial working memory improvement by an alpha2-adrenoceptor agonist dexmedetomidine is not mediated through alpha2C-adrenoceptor.
    Progress in neuro-psychopharmacology & biological psychiatry, 2001, Volume: 25, Issue:8

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Dexmedetomidine; Female; Maze Learning; Memory; Mice; Mice, Knockout; Receptors, Adrenergic, alpha-2; Spatial Behavior

2001