dexmedetomidine has been researched along with Acute Lung Injury in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.92) | 29.6817 |
| 2010's | 26 (50.00) | 24.3611 |
| 2020's | 25 (48.08) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, B; Ding, Y; Feng, A; Lv, Y; Shi, J; Wang, M; Zeng, M; Zhang, B; Zhang, Q; Zhao, C; Zheng, X | 1 |
| Bian, Q; Gu, L; Jiao, D; Li, P; Wang, L; Xu, Z | 1 |
| Fang, M; Hu, H; Liang, Z; Sun, H; Tao, T; Xu, X | 1 |
| Cai, J; Huang, D; Lin, Y; Lu, J; Luo, Z; Yu, S; Zhou, B | 1 |
| Hu, C; Hu, J; Li, J; Li, Y; Lian, Q; Ma, D; Wu, B | 1 |
| Dong, S; Gao, Q; Shi, J; Song, K; Yang, J; Yu, J; Zhan, L; Zhang, Y | 1 |
| Gao, X; Li, P; Lv, Z; Zhang, W | 1 |
| Chen, S; Huan, Y; Tailaiti, T; Wang, J; Wu, J; Yang, L; Zou, T | 1 |
| Han, DW; Han, Y; Lim, BJ; Oh, JE; Song, Y | 1 |
| He, ZW; Li, KF; Lin, SH; Luo, RJ; Xie, K; Xu, F; Zhang, DY; Zhang, ZT | 1 |
| Li, Y; Lu, Y; Morimatsu, H; Nakamura, R; Omori, E; Sakamoto, R; Shimizu, H; Takahashi, T | 1 |
| Huang, M; Liu, C; Liu, J; Sun, J; Wang, H; Wang, J; Yu, H; Zhai, M; Zhang, Y; Zhao, J; Zhu, Y | 1 |
| He, H; Hu, S; Huang, X; Liu, J; Meng, Z | 1 |
| Chen, L; Cheng, L; Lin, L; Song, Q; Zhong, W | 1 |
| Huang, Q; Kong, Q; Qiu, Z; Song, X; Wu, X; Xia, Z | 1 |
| Bian, W; Chen, Y; Xu, B | 1 |
| Zhang, Z | 1 |
| Ding, L; Gao, X; Sheng, L; Yu, S | 1 |
| Huang, Q; Kong, Q; Ming, T; Wu, X; Xia, Z; Yuan, M | 1 |
| He, W; Liu, J; Liu, X; Sun, Y; Xia, Y; Ye, H; Yuan, X | 1 |
| Chen, Y; Huang, Y; Luo, H; Song, X; Xiong, B | 1 |
| Ding, X; Gong, C; Qian, Y; Zhang, Y; Zhang, Z; Zhu, L | 1 |
| Dai, Z; Huang, Q; Jiang, Y; Xia, M; Xu, J; Zhang, X | 1 |
| An, CY; Li, KH; Li, L; Li, LZ; Li, YL; Wu, GY; Zhang, ZM | 1 |
| Dong, S; Du, S; He, S; Hu, X; Li, C; Li, H; Li, X; Shi, J; Song, K; Xie, Z; Yu, J; Yu, T; Zhang, Y | 1 |
| Cui, H; Zhang, Q | 1 |
| Liu, H; Liu, T; Wu, D; Yang, Y; Zhang, Q | 1 |
| Gao, T; Jia, S; Liu, Z; Wang, Y; Zhang, R; Zhang, Y | 1 |
| Tan, X; Xue, L; Zhang, Y | 1 |
| Fan, X; Li, K; Li, L; Li, X; Lu, S; Meng, L; Su, Z; Wang, Y; Zhao, G | 1 |
| Çelik, F; Doğan, E; Güzel, A; Kaplan, İ; Kuyumcu, M; Türkçü, G; Yıldırım, ZB | 1 |
| Cai, JQ; Cao, CC; Guo, RJ; Jia, L; Xu, WX; Xue, X; Yang, HJ; Zhao, W | 1 |
| Li, B; Sun, M; Zhang, J; Zhang, S; Zhang, W | 1 |
| Hu, PS; Liu, J; Meng, PZ; Tong, F | 1 |
| Bo, L; Deng, X; Wang, C; Wang, H; Wang, Y; Zhang, D | 1 |
| Liu, Z; Wang, X; Yu, L; Zhang, Y | 1 |
| Ding, M; Li, JY; Ren, HC; Wang, G; Wang, Q; Weng, YQ; Xu, RB; Yu, HL; Yu, WL | 1 |
| Deng, QT; Geng, Y; He, SX; Li, R; Ma, Q; Shao, XY; Wu, YS; Xu, WW; Yang, HH | 1 |
| Liang, S; Liu, Y; Wang, Y | 1 |
| Liang, FQ; Lin, Q; Xie, T; Zhang, JR | 1 |
| Chen, Y; Fan, H; Feng, X; Hu, X; Li, B; Sha, J; Zhang, H | 1 |
| Akkuş, M; Altekin, E; Cilaker Mıcılı, S; Duru, S; Ergür, BU; Girgin, P; Gündüz, K; Güzeldağ, S; Koca, U; Olguner, ÇG; Taşdöğen, A | 1 |
| Araújo, MN; Cavalcanti, V; Fernandes, FC; Heil, LB; Morales, MM; Pelosi, P; Rocco, PR; Samary, CS; Santos, CL; Silva, PL; Villela, N | 1 |
| Cai, J; Chi, X; Gao, W; Guan, J; Li, X; Wang, Y; Wei, X; Yu, X | 1 |
| Li, C; Lv, C; Wang, Y; Xu, Y; Yin, X; Zhang, R; Zhang, X; Zhao, W | 1 |
| Dai, ZL; Gao, LK; Huang, Q; Jiang, YX; Zhang, XP; Zhao, W | 1 |
| Chen, Q; Gu, J; Lu, K; Ma, D; Ma, J; Ning, J; Wu, L; Yi, B | 1 |
| Li, N; Lin, CS; Liu, J; Liu, L; Ouyang, BS; Xing, DD | 1 |
| Cai, S; Cai, Y; Dai, X; Fu, C; Lin, M; Yang, Y | 1 |
| Huang, CJ; Tsai, PS; Wang, TY; Yang, CH | 1 |
| Hanci, V; Sipahi, EY; Turan, IÖ; Yurdakan, G; Yurtlu, S | 1 |
| Fang, H; Shi, QQ; Wang, H | 1 |
2 trial(s) available for dexmedetomidine and Acute Lung Injury
| Article | Year |
|---|---|
Activation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Pilot Projects; Prospective Studies; Proto-Oncogene Proteins c-akt; Signal Transduction; Thoracic Surgery, Video-Assisted | 2020 |
Paravertebral dexmedetomidine as an adjuvant to ropivacaine protects against independent lung injury during one-lung ventilation: a preliminary randomized clinical trial.
Topics: Acute Lung Injury; Adult; Aged; Anesthetics, Local; Dexmedetomidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Inflammation Mediators; Male; Middle Aged; One-Lung Ventilation; Retrospective Studies; Ropivacaine | 2018 |
50 other study(ies) available for dexmedetomidine and Acute Lung Injury
| Article | Year |
|---|---|
Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways.
Topics: Acute Lung Injury; Animals; Apoptosis; Flavones; Inflammation; Lipopolysaccharides; Mice; NF-kappa B; Oxidative Stress; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Long non-coding RNA MALAT1 enhances the protective effect of dexmedetomidine on acute lung injury by sponging miR-135a-5p to downregulate the ratio of X-box binding proteins XBP-1S/XBP-1U.
Topics: Acute Lung Injury; Animals; Cell Line, Tumor; Dexmedetomidine; Down-Regulation; Endoplasmic Reticulum Stress; Humans; Lung; MicroRNAs; Protective Agents; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; X-Box Binding Protein 1 | 2021 |
Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation.
Topics: Acute Lung Injury; Animals; Cecum; Cell Line; Cell Nucleus; Cytokines; Dexmedetomidine; Disease Models, Animal; HMGB1 Protein; Inflammation Mediators; Lentivirus; Ligation; Lung; Male; Mice, Inbred C57BL; Protective Agents; Protein Transport; Pyroptosis; Receptor for Advanced Glycation End Products; RNA, Messenger; Signal Transduction | 2021 |
Effects of dexmedetomidine on the expression profile of tsRNAs in LPS-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Disease Models, Animal; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; RNA, Transfer; Sequence Analysis, RNA; Signal Transduction; Transcriptome | 2022 |
The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats.
Topics: Acetylcholine; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Catecholamines; Dexmedetomidine; Interleukin-1beta; Lung; Protective Agents; Rats; Rats, Sprague-Dawley; Sepsis; Treatment Outcome; Tumor Necrosis Factor-alpha; Vagotomy; Vagus Nerve | 2022 |
Dexmedetomidine modulates mitochondrial dynamics to protect against endotoxin-induced lung injury via the protein kinase C-ɑ/haem oxygenase-1 signalling pathway.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Endotoxins; Humans; Lung; Mice; Mitochondrial Dynamics; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley | 2022 |
Stellate Ganglion Block Combined with Dexmedetomidine Protects Obese Rats from Lipopolysaccharide-Induced Acute Lung Injury.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Humans; Lipopolysaccharides; Male; Obesity; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Stellate Ganglion; Tumor Necrosis Factor-alpha | 2022 |
Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1α.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Diabetes Mellitus, Experimental; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Signal Transduction | 2022 |
Dexmedetomidine attenuates subarachnoid hemorrhage-induced acute lung injury through regulating autophagy and TLR/NFκB signaling pathway.
Topics: Acute Lung Injury; Animals; Autophagy; Dexmedetomidine; Interleukin-6; Male; NF-kappa B; Pulmonary Edema; Rats; Rats, Wistar; Signal Transduction; Subarachnoid Hemorrhage; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2022 |
Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Dexmedetomidine; Forkhead Transcription Factors; Lung; Mice; Mice, Inbred C57BL; Respiratory Distress Syndrome; Sirtuin 1 | 2023 |
Dexmedetomidine improves acute lung injury by activating autophagy in a rat hemorrhagic shock and resuscitation model.
Topics: Acute Lung Injury; Animals; Autophagy; Beclin-1; Dexmedetomidine; Lung; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic | 2023 |
Sigma-1 receptor regulates the endoplasmic reticulum stress pathway in the protective mechanism of dexmedetomidine against hyperoxia-induced lung injury.
Topics: Acute Lung Injury; Dexmedetomidine; Endoplasmic Reticulum Stress; Humans; Hyperoxia; Oxygen; Sigma-1 Receptor | 2024 |
Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Caveolin 1; Cytokines; Dexmedetomidine; Lipopolysaccharides; Lung; Male; NF-kappa B; Organ Size; Peroxidase; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Co-administration of N-acetylcysteine and dexmedetomidine plays a synergistic effect on protection of LPS-induced acute lung injury via correcting Th1/Th2/Th17 cytokines imbalance.
Topics: Acetylcysteine; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Basic Helix-Loop-Helix Transcription Factors; Cytokines; Dexmedetomidine; Drug Synergism; Drug Therapy, Combination; Free Radical Scavengers; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Th1 Cells; Th17 Cells; Th2 Cells | 2020 |
Protective Effect of Dexmedetomidine on Acute Lung Injury via the Upregulation of Tumour Necrosis Factor-α-Induced Protein-8-like 2 in Septic Mice.
Topics: Acute Lung Injury; Administration, Intravenous; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Gene Transfer Techniques; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Random Allocation; Sepsis; Treatment Outcome; Up-Regulation | 2020 |
Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion.
Topics: Acute Lung Injury; Animals; Antioxidants; Cytokines; Dexmedetomidine; Disease Models, Animal; Heme Oxygenase-1; Lung; Male; Malondialdehyde; NF-E2 Transcription Factor; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Superoxide Dismutase | 2020 |
Dexmedetomidine For The Treatment Of Acute Lung Injury: A Fact Or Fiction?
Topics: Acute Lung Injury; Aged; Animals; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats | 2020 |
miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14.
Topics: Acute Lung Injury; Analgesics, Non-Narcotic; Animals; Dexmedetomidine; Male; Mice; MicroRNAs; Mitogen-Activated Protein Kinase 14; Sepsis | 2020 |
Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock‑resuscitation‑induced acute lung injury through inhibiting the NLRP3 inflammasome.
Topics: Acute Lung Injury; Animals; Cytokines; Dexmedetomidine; Disease Models, Animal; Gene Expression Regulation; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Male; Malondialdehyde; NLR Family, Pyrin Domain-Containing 3 Protein; Peroxidase; Rats; Resuscitation; Shock, Hemorrhagic; Signal Transduction; Superoxide Dismutase; Thoracic Injuries; Wounds, Nonpenetrating | 2020 |
Dexmedetomidine alleviates LPS‑induced acute lung injury via regulation of the p38/HO‑1 pathway.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Interleukin-1beta; Lipopolysaccharides; Male; NLR Family, Pyrin Domain-Containing 3 Protein; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome | 2020 |
Dexmedetomidine ameliorates renal ischemia reperfusion-mediated activation of the NLRP3 inflammasome in alveolar macrophages.
Topics: Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; Cell Line; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Ischemia; Macrophages, Alveolar; NADPH Oxidase 4; Nitric Oxide Synthase Type III; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger | 2020 |
Dexmedetomidine alleviates pulmonary edema through the epithelial sodium channel (ENaC) via the PI3K/Akt/Nedd4-2 pathway in LPS-induced acute lung injury.
Topics: A549 Cells; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cell Survival; Cytokines; Dexmedetomidine; Edema; Epithelial Sodium Channels; Humans; Lipopolysaccharides; Lung; Male; Nedd4 Ubiquitin Protein Ligases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction | 2021 |
The effects of dexmedetomidine administered at various times on acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Hypnotics and Sedatives; Injections, Intraperitoneal; Lipopolysaccharides; Male; Organ Size; Rats; Rats, Wistar; Time Factors | 2021 |
Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Endotoxins; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mitochondrial Dynamics; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction | 2021 |
Dexmedetomidine ameliorates lipopolysaccharide-induced acute lung injury by inhibiting the PI3K/Akt/FoxO1 signaling pathway.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Forkhead Box Protein O1; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2021 |
Dexmedetomidine Alleviates Hyperoxia-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation.
Topics: Acute Lung Injury; Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Bronchoalveolar Lavage Fluid; Cell Hypoxia; Cytokines; Dexmedetomidine; Female; Inflammasomes; Lipopolysaccharides; Lung; Membrane Potential, Mitochondrial; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; RAW 264.7 Cells; Reactive Oxygen Species; Superoxide Dismutase | 2017 |
Dexmedetomidine mitigate acute lung injury by inhibiting IL-17-induced inflammatory reaction.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Movement; Cells, Cultured; Cytokines; Dexmedetomidine; Epithelial Cells; Inflammation; Interleukin-17; Lung; Mice; Mice, Inbred Strains; Neutrophils; NF-kappa B | 2018 |
The alpha2-adrenoreceptor agonist dexmedetomidine protects against lipopolysaccharide-induced apoptosis via inhibition of gap junctions in lung fibroblasts.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Analgesics; Apoptosis; Cell Line; Connexin 43; Dexmedetomidine; Fibroblasts; Gap Junctions; Humans; Lipopolysaccharides; Lung | 2018 |
The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways.
Topics: Acute Lung Injury; Animals; Cells, Cultured; Cytoprotection; Dexmedetomidine; HMGB1 Protein; Humans; Kidney; Lipopolysaccharides; Male; NF-kappa B; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4; TOR Serine-Threonine Kinases | 2018 |
Dexmedetomidine and Magnesium Sulfate: A Good Combination Treatment for Acute Lung Injury?
Topics: Acute Lung Injury; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Hemodynamics; Humans; Hydrochloric Acid; Lung; Magnesium Sulfate; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Respiration, Artificial; Signal Transduction | 2019 |
Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system.
Topics: Acute Lung Injury; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Immune System; Inflammation; Ki-67 Antigen; NF-kappa B; Protective Agents; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Taurine | 2018 |
Protective Effect of Dexmedetomidine on Endotoxin-Induced Acute Lung Injury in Rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Disease Models, Animal; Endotoxins; Lipopolysaccharides; Lung; Male; Rats; Rats, Sprague-Dawley | 2018 |
Dexmedetomidine Protects Against Traumatic Brain Injury-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Brain Injuries, Traumatic; Bronchoalveolar Lavage Fluid; Dexmedetomidine; HMGB1 Protein; Lung; Male; Mice; Mice, Inbred C57BL; Models, Animal; Protective Agents; Pulmonary Edema; Receptor for Advanced Glycation End Products; Signal Transduction | 2018 |
Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Cytokines; Dexamethasone; Dexmedetomidine; Gene Expression Regulation; Lipopolysaccharides; Lung; Male; Mice, Inbred C57BL; MicroRNAs; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Proteolysis; Pulmonary Edema; Random Allocation; RNA Interference | 2018 |
Protective effect of ulinastatin combined with dexmedetomidine on lung injury after cold ischemia-reperfusion in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cold Ischemia; Cytokines; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Glycoproteins; Inflammation Mediators; Lipid Peroxidation; Liver Transplantation; Lung; Male; Malondialdehyde; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase | 2018 |
Dexmedetomidine Attenuates Acute Lung Injury Induced by Heatstroke and Improve Outcome.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Heat Stress Disorders; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Dexmedetomidine alleviates lung ischemia-reperfusion injury in rats by activating PI3K/Akt pathway.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Disease Models, Animal; Humans; Lung; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2019 |
Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption.
Topics: Acute Lung Injury; Animals; Apoptosis; Dexmedetomidine; Lung; Male; Mice; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Oxidative Stress; Oxygen Consumption; Respiratory Function Tests; Sepsis | 2019 |
Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor | 2019 |
The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis.
Topics: Acute Kidney Injury; Acute Lung Injury; Acute-Phase Proteins; Animals; Apoptosis; Caspase 3; Cecum; Cell Count; Creatinine; Dexmedetomidine; Disease Models, Animal; DNA Fragmentation; Kidney; Lipocalin-2; Lipocalins; Lung; Macrophages, Alveolar; Male; Malondialdehyde; Proto-Oncogene Proteins; Rats; Rats, Wistar; Sepsis | 2013 |
Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury.
Topics: Acute Lung Injury; Animals; Cytokines; Dexmedetomidine; Disease Models, Animal; Endotoxins; Female; Hypnotics and Sedatives; Lipopolysaccharides; Lung; NF-E2 Transcription Factor; Nitric Oxide Synthase; Propofol; Rats; Rats, Wistar; RNA, Messenger; Statistics, Nonparametric; Thiopental | 2014 |
Dexmedetomidine ameliorates acute lung injury following orthotopic autologous liver transplantation in rats probably by inhibiting Toll-like receptor 4-nuclear factor kappa B signaling.
Topics: Acute Lung Injury; Animals; Dexmedetomidine; Interleukin-1beta; Liver Transplantation; Lung; Male; NF-kappa B; Organ Size; Peroxidase; Phosphorylation; Protein Subunits; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Transplantation, Autologous; Tumor Necrosis Factor-alpha | 2015 |
Dexmedetomidine attenuates acute lung injury induced by lipopolysaccharide in mouse through inhibition of MAPK pathway.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cytokines; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Inflammation Mediators; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Neutrophil Infiltration; Phosphorylation; Pulmonary Edema; Time Factors; Transcription Factors; Transcription, Genetic | 2015 |
Dexmedetomidine alleviates pulmonary edema by upregulating AQP1 and AQP5 expression in rats with acute lung injury induced by lipopolysaccharide.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Aquaporin 1; Aquaporin 5; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Injections, Intravenous; Interleukin-1beta; Lipopolysaccharides; Lung; Male; Organ Size; Pulmonary Edema; Rats; Rats, Wistar; Signal Transduction; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2015 |
α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury.
Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Endothelium; Focal Adhesion Kinase 1; Humans; Imidazoles; Kidney; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction | 2016 |
Dexmedetomidine protected COPD-induced lung injury by regulating miRNA-146a.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Dexmedetomidine; Disease Models, Animal; Gene Expression Regulation; Interleukin-1beta; Lung; MicroRNAs; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Tumor Necrosis Factor-alpha | 2016 |
Dexmedetomidine attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress, mitochondrial dysfunction and apoptosis in rats.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Apoptosis; Dexmedetomidine; Lipopolysaccharides; Lung; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2017 |
Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Blood Pressure; Bronchoalveolar Lavage Fluid; Dexmedetomidine; Drug Combinations; Inflammation Mediators; Infusions, Intravenous; Ketamine; Lung; Macrophages, Alveolar; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Up-Regulation | 2009 |
Protective effect of dexmedetomidine in a rat model of α-naphthylthiourea-induced acute lung injury.
Topics: Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Drug Interactions; Lung; Male; Pleural Effusion; Pneumonia; Pulmonary Edema; Rats; Rats, Wistar; Rodenticides; Thiourea | 2012 |
Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats.
Topics: Acute Lung Injury; Adrenergic alpha-Agonists; Animals; Base Sequence; Dexmedetomidine; DNA Primers; Dose-Response Relationship, Drug; Female; Male; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley | 2012 |