dexmedetomidine has been researched along with Acute Kidney Failure in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.35) | 29.6817 |
| 2010's | 37 (50.00) | 24.3611 |
| 2020's | 36 (48.65) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, HR; Feng, XM; Ji, FH; Liu, H; Peng, K; Shan, XS; Yang, BW; Zhao, D | 1 |
| Dhargalkar, J; Dorsey, V; Farias, JS; Flores, S; Loomba, RS; Rausa, J; Villarreal, EG | 1 |
| Budts, W; Cloet, N; Gewillig, M; Kutty, S; Mekahli, D; Pottel, H; Sá, MPBO; Toelen, J; Van den Eynde, J; Van Lerberghe, R; Verbakel, JY; Vlasselaers, D | 1 |
| Chan, YS; Chang, CH; Chen, DY; Chen, SW; Cheng, YT; Chou, AH; Chu, PH; Lee, KT; Liu, KS; Wu, VC | 1 |
| Bhatia, M; Billings, FT; Bollen, BA; Fox, AA; Geube, MA; Ji, F; Liu, H; McIlroy, DR; Peng, K; Popescu, WM; Schwann, NM; Shaw, AD; Shore-Lesserson, L; Zarbock, A; Zhou, S | 1 |
| Chen, Q; Feng, J; Hu, Q; Jia, J; Liao, YH; Liu, X | 1 |
| An, S; Chen, Z; Hu, H; Jin, Y; Li, L; Sha, T; Wu, F; Wu, J; Zeng, Z | 1 |
| Chen, P; Chen, Y; Hu, B; Jiang, T; Li, X; Liu, W; Tian, T; Xue, F | 1 |
| Arpa, M; Mataracı Karakaş, S; Mercantepe, F; Mercantepe, T; Ozdemir, A; Topçu, A; Tümkaya, L | 1 |
| Comert, B; Ergan, B; Ergun, B; Gokmen, AN; Heybeli, C; Kucuk, M; Ozturk, MC; Yakar, MN | 1 |
| Le, Y; Li, B; Liao, Q; Liu, X; Tang, YZ; Wang, Q; Zhang, W; Zhi, L | 1 |
| Jiang, L; Jiang, Z; Lu, G; Qian, J; Yang, A; Yang, J; Zhou, B | 1 |
| Ergene, S; Hemsinli, D; Karakisi, SO; Mercantepe, T; Tumkaya, L; Yılmaz, A | 1 |
| Chen, B; Liu, ZK; Luo, HR; Qiu, YQ; Wu, PY; Yang, LP; Zhong, LY; Zhong, XH; Zhuang, LP | 1 |
| Ding, Y; Dong, Y; Liu, Y; Su, Y; Sun, W; Wang, D; Xu, L | 1 |
| Chen, L; Li, M; Li, Y; Liang, M; Lin, Y; Zeng, K | 1 |
| Daminet, S; Kutter, APN; Major, A; Steblaj, B; Stirn, M; Zini, E | 1 |
| Gao, P; Jin, Y; Liu, J; Wang, H; Wang, W; Zhang, P | 1 |
| Bailey, SR; Bellomo, R; Evans, RG; Farmer, DGS; Hood, SG; Iguchi, N; Lankadeva, YR; Ma, S; May, CN | 1 |
| Applegate, RL; Ji, FH; Li, D; Liu, H; Lubarsky, DA; Peng, K | 1 |
| Liu, Y; Wang, C; Yu, Y; Zhang, J | 1 |
| Echavarría, R; Figueroa, F; Franco-Acevedo, A; Garcia, D; Goldaraz-Monraz, MP; Melo, Z; Moreno-Carranza, B; Palomino, J; Portilla-Debuen, E | 1 |
| Wieruszewski, PM; Wittwer, ED | 2 |
| Kanmura, Y; Kiyonaga, N; Moriyama, T | 1 |
| Chai, Y; Jia, H; Li, C; Shen, J; Wang, X; Yong, F; Zhu, K | 1 |
| Chen, M; Gong, F; Hong, J; Hu, B; Jiang, L; Liu, J; Mo, S; Shi, K; Sun, R; Tu, Y; Xu, L; Yang, X; Zheng, Y | 1 |
| He, J; Kang, L; Ni, J; Wang, L; Yin, S; Zhong, Z | 1 |
| Grocott, HP; Kashani, HH | 1 |
| Chai, X; Gao, J; Geng, Q; Hu, Y; Jiang, J; Liang, X; Shi, S; Tang, C; Wang, J | 1 |
| Chen, Y; Huang, Y; Luo, H; Song, X; Xiong, B | 1 |
| Jang, YE; Ji, SH; Kim, EH; Kim, HS; Kim, JT; Kim, WH; Kwak, JG; Lee, JH | 1 |
| Gao, Y; Han, QY; Huang, R; Kang, K; Kong, WL; Li, JY; Li, M; Li, NN; Liu, HT; Liu, RJ; Liu, YS; Qi, ZD; Wang, HL; Wang, SC; Yang, ZY; Yu, KJ; Zhang, WH; Zhang, X; Zhao, MY; Zheng, JB | 1 |
| Chen, Q; Liu, J; Ren, A; Zhang, M; Zhou, K; Zhu, H | 1 |
| Ma, S; Ma, X; Yang, H; Zhou, W | 1 |
| Liu, SH; Su, K; Xue, FS | 1 |
| Li, RH; Liu, R; Song, YC; Xu, F | 1 |
| Li, F; Liu, H; Mo, H; Pan, D; Sun, W; Wang, X; Wen, S; Zhou, A | 1 |
| Han, M; Huang, X; Kang, F; Li, J; Zhai, M | 1 |
| Chang, YJ; Choi, CH; Jo, YY; Kim, JY; Kwak, HJ; Lee, JY | 1 |
| Shi, R; Tie, HT | 1 |
| Ding, LL; Li, HX; Liu, YY; Xue, FS | 1 |
| Liu, YY; Xue, FS; Yang, GZ | 1 |
| Chen, C; Chen, X; Han, M; Li, J; Li, Q | 1 |
| Gao, X; Hei, Z; Huang, P; Ji, H; Qiu, R; Sha, W; Wang, F; Yao, W; Yuan, D | 1 |
| De Bels, D; Honore, PM; Preseau, T; Spapen, HD | 1 |
| Gao, Y; Huang, R; Kang, K; Kong, WL; Liu, HT; Liu, RJ; Liu, YS; Qi, ZD; Qu, JD; Wang, HL; Wang, SC; Yu, KJ; Zhang, X; Zheng, JB | 1 |
| Dai, D; Ge, S; Li, X; Liu, H; Zhang, C | 1 |
| Fan, H; Feng, X; Guan, W; Song, M; Wang, C; Yang, T; Yao, Y; Zhao, Y | 1 |
| Wang, L; Wang, TL; Xu, MJ; Zhang, QL | 1 |
| Cai, J; Chen, J; Cheng, N; Ge, M; Guo, N; Wu, S; Yao, H | 1 |
| Chen, H; Jiang, XQ; Jin, YH; Li, ZT; Wu, F; Zhang, YY | 1 |
| Baskol, G; Bayram, A; Deniz, K; Erkan, GN; Esmaoglu, A; Talih, G; Yildiz, K | 1 |
| Akkuş, M; Altekin, E; Cilaker Mıcılı, S; Duru, S; Ergür, BU; Girgin, P; Gündüz, K; Güzeldağ, S; Koca, U; Olguner, ÇG; Taşdöğen, A | 1 |
| Fleming, N; Ji, F; Li, Z; Liu, H; Nguyen, H; Shi, P; Young, N | 1 |
| Ji, F; Li, Z; Liu, H; Yeranossian, A; Young, JN | 1 |
| Balkanay, OO; Goksedef, D; Ipek, G; Omeroglu, SN | 1 |
| Braz, JR; Braz, LG; Castiglia, YM; de Carvalho, AL; Domingues, MA; Kakuda, CM; Módolo, MP; Módolo, NS; Ribeiro, OR; Vital, RB | 1 |
| Milles, K; Zarbock, A | 1 |
| Cata, JP; Feng, L; Moon, T; Peng, SP; Tsai, JY; Vachhani, S; Vaporciyan, AA | 1 |
| Cho, JS; Kim, MK; Kwak, YL; Shim, JK; Soh, S | 1 |
| Chen, YJ; Gong, CL; Tan, F; Zhou, SL | 1 |
| Cai, J; Chi, X; Huang, P; Jin, Y; Wang, Y; Wu, S; Xia, Z; Yao, H | 1 |
| Axelrod, DM; Krawczeski, CD; Kwiatkowski, DM; Sutherland, SM; Tesoro, TM | 1 |
| He, A; Huang, L; Liu, G; Qiu, L; Song, H; Tong, F; Wan, Q; Wang, X; Xia, Y | 1 |
| Aksoy, N; Aydogan, H; Büyükfirat, E; Karahan, MA; Kocarslan, S; Kücük, A; Taskın, A; Yalcin, S; Yüce, HH | 1 |
| Chu, HC; Xue, F; Zhang, W | 1 |
| Chen, Q; Gu, J; Lu, K; Ma, D; Ma, J; Ning, J; Wu, L; Yi, B | 1 |
| Fu, S; Li, S; Xiao, Y; Xu, G | 1 |
| Meersch, M; Zarbock, A | 1 |
| Liang, H; Liu, HZ; Wang, HB; Yang, CX; Zhang, B; Zhong, JY | 1 |
| Gulcu, N; Kocoglu, H; Ozturk, H; Yilmaz, F | 1 |
| Gu, J; Ma, D; Maze, M; Sanders, RD; Sun, P; Terrando, N; Watts, HR; Xia, P; Zhao, H | 1 |
| Chen, TC; Hsing, CH; Li, CF; Lin, CF; So, E; Sun, DP; Yeh, CH | 1 |
12 review(s) available for dexmedetomidine and Acute Kidney Failure
| Article | Year |
|---|---|
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Dexmedetomidine; Humans; Hypnotics and Sedatives; Kidney | 2022 |
Strategies to Prevent Acute Kidney Injury after Pediatric Cardiac Surgery: A Network Meta-Analysis.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Age Factors; Bayes Theorem; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child, Preschool; Dexmedetomidine; Female; Humans; Infant; Infant, Newborn; Ischemic Preconditioning; Male; Network Meta-Analysis; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2021 |
Society of Cardiovascular Anesthesiologists Clinical Practice Update for Management of Acute Kidney Injury Associated With Cardiac Surgery.
Topics: Acute Kidney Injury; Adult; Anesthesiologists; Cardiac Surgical Procedures; Dexmedetomidine; Dopamine; Humans; Oxygen; Vasoconstrictor Agents | 2022 |
Effect of dexmedetomidine for prevention of acute kidney injury after cardiac surgery: an updated systematic review and meta-analysis.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Humans; Intensive Care Units | 2022 |
Perioperative dexmedetomidine administration does not reduce the risk of acute kidney injury after non-cardiac surgery: a meta-analysis.
Topics: Acute Kidney Injury; Bradycardia; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Hypotension; Randomized Controlled Trials as Topic | 2022 |
[Dexmedetomidine can not reduce the incidence of acute and chronic kidney disease after laparoscopic radical nephrectomy: a propensity score matching-based analysis].
Topics: Acute Kidney Injury; Dexmedetomidine; Humans; Incidence; Kidney Neoplasms; Laparoscopy; Nephrectomy; Propensity Score; Renal Insufficiency, Chronic; Retrospective Studies | 2023 |
Effect of Dexmedetomidine on Cardiac Surgery-Associated Acute Kidney Injury: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials.
Topics: Acute Kidney Injury; Adult; Aged; Cardiac Surgical Procedures; China; Dexmedetomidine; Humans; Middle Aged; Randomized Controlled Trials as Topic | 2020 |
Dexmedetomidine as a promising prevention strategy for cardiac surgery-associated acute kidney injury: a meta-analysis.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2017 |
Efficacy of dexmedetomidine in prevention of junctional ectopic tachycardia and acute kidney injury after pediatric cardiac surgery: A meta-analysis.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Child; Dexmedetomidine; Glucocorticoids; Humans; Postoperative Complications; Tachycardia, Ectopic Junctional; Treatment Outcome | 2018 |
Novel therapy for renal protection.
Topics: Acute Kidney Injury; Crystalloid Solutions; Dexmedetomidine; Fluid Therapy; Humans; Hypnotics and Sedatives; Ischemic Preconditioning; Isotonic Solutions; Postoperative Complications; Surgical Procedures, Operative | 2015 |
Recent Perioperative Pharmacological Prevention of Acute Kidney Injury after Cardiac Surgery: A Narrative Review.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Hydrazones; Perioperative Care; Postoperative Complications; Pyridazines; Risk Factors; Simendan | 2017 |
Renal protection in the 21st century.
Topics: Acute Kidney Injury; Critical Care; Critical Illness; Crystalloid Solutions; Dexmedetomidine; Fluid Therapy; Hemodynamics; Humans; Hypnotics and Sedatives; Isotonic Solutions; Kidney | 2016 |
13 trial(s) available for dexmedetomidine and Acute Kidney Failure
| Article | Year |
|---|---|
Dexmedetomidine reduces acute kidney injury after endovascular aortic repair of Stanford type B aortic dissection: A randomized, double-blind, placebo-controlled pilot study.
Topics: Acute Kidney Injury; Aortic Dissection; Dexmedetomidine; Endovascular Procedures; Humans; Pilot Projects; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome | 2021 |
Effect of Dexmedetomidine on Postoperative Renal Function in Patients Undergoing Cardiac Valve Surgery Under Cardiopulmonary Bypass: A Randomized Clinical Trial.
Topics: Acute Kidney Injury; Cardiopulmonary Bypass; Dexmedetomidine; Heart Valves; Humans; Kidney | 2023 |
Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.
Topics: Acute Kidney Injury; Aged; Animals; Apoptosis; China; Dexmedetomidine; Endoplasmic Reticulum Stress; Female; Humans; Ischemia; Kidney; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2020 |
Effects of intraoperative dexmedetomidine on the incidence of acute kidney injury in pediatric cardiac surgery patients: A randomized controlled trial.
Topics: Acute Kidney Injury; Adult; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Child; Dexmedetomidine; Humans; Incidence | 2020 |
Effects of Dexmedetomidine on Patients Undergoing Laparoscopic Surgery for Colorectal Cancer.
Topics: Acute Kidney Injury; Colorectal Neoplasms; Dexmedetomidine; Humans; Kidney; Laparoscopy | 2021 |
The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Biomarkers; Blood Urea Nitrogen; Cardiopulmonary Bypass; Creatinine; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Interleukin-8; Lipocalin-2; Male; Middle Aged; Perioperative Care; Prospective Studies; Superoxide Dismutase; Urination; Young Adult | 2017 |
The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial.
Topics: Acute Kidney Injury; Biomarkers; Cardiopulmonary Bypass; Child; Child, Preschool; Dexmedetomidine; Female; Glomerular Filtration Rate; Humans; Incidence; Infant; Intraoperative Care; Kidney; Male; Postoperative Complications; Protective Agents; Treatment Outcome | 2017 |
Protective effect of dexmedetomidine on kidney injury of parturients with preeclampsia undergoing cesarean section: a randomized controlled study.
Topics: Acute Kidney Injury; Adult; Cesarean Section; Dexmedetomidine; Double-Blind Method; Female; Humans; Male; Pre-Eclampsia; Pregnancy | 2019 |
Determining whether dexmedetomidine provides a reno-protective effect in patients receiving laparoscopic radical prostatectomy: a pilot study.
Topics: Acute Kidney Injury; Aged; Dexmedetomidine; Double-Blind Method; Humans; Intraoperative Care; Laparoscopy; Male; Middle Aged; Pilot Projects; Postoperative Complications; Prospective Studies; Prostatectomy | 2019 |
Perioperative dexmedetomidine improves outcomes of cardiac surgery.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aged; Cardiac Surgical Procedures; Catecholamines; Delirium; Dexmedetomidine; Female; Heart Diseases; Hospital Mortality; Hospital Records; Humans; Hypnotics and Sedatives; Length of Stay; Male; Middle Aged; Myocardial Ischemia; Patient Readmission; Perioperative Care; Postoperative Complications; Respiration, Artificial; Retrospective Studies; Sepsis; Stroke; Treatment Outcome | 2013 |
Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aged; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dexmedetomidine; Humans; Incidence; Kidney; Male; Postoperative Complications; Postoperative Period; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors | 2013 |
The dose-related effects of dexmedetomidine on renal functions and serum neutrophil gelatinase-associated lipocalin values after coronary artery bypass grafting: a randomized, triple-blind, placebo-controlled study.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Aged; Biomarkers; Blood Urea Nitrogen; Coronary Artery Bypass; Coronary Artery Disease; Creatinine; Cytoprotection; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Humans; Hypnotics and Sedatives; Infusions, Intravenous; Kidney; Lipocalin-2; Lipocalins; Male; Middle Aged; Predictive Value of Tests; Proto-Oncogene Proteins; Tertiary Care Centers; Time Factors; Treatment Outcome; Turkey | 2015 |
Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aged; Cardiac Surgical Procedures; Dexmedetomidine; Drug Administration Schedule; Female; Heart Valve Diseases; Heart Valves; Hemodynamics; Humans; Incidence; Infusions, Parenteral; Length of Stay; Male; Middle Aged; Prospective Studies; Republic of Korea; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome | 2016 |
49 other study(ies) available for dexmedetomidine and Acute Kidney Failure
| Article | Year |
|---|---|
Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome.
Topics: Acute Kidney Injury; Aged; Aortic Dissection; Atrial Fibrillation; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Hospital Mortality; Humans; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Taiwan | 2022 |
Association between dexmedetomidine administration and outcomes in critically ill patients with sepsis-associated acute kidney injury.
Topics: Acute Kidney Injury; Cohort Studies; Critical Illness; Dexmedetomidine; Humans; Intensive Care Units; Retrospective Studies; Sepsis | 2022 |
The effects of dexmedetomidine on early acute kidney injury in severely burned rats.
Topics: Acute Kidney Injury; Animals; Burns; Dexmedetomidine; Interleukin-1; Male; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2023 |
Dexmedetomidine may reduce the risk of acute kidney injury development in critically ill patients during colistin therapy.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Colistin; Critical Illness; Dexmedetomidine; Gram-Negative Bacteria; Humans; Intensive Care Units; Retrospective Studies; Risk Factors | 2023 |
Intraoperative dexmedetomidine use is associated with lower incidence of acute kidney injury after non-cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Incidence; Retrospective Studies | 2023 |
Effects of dexmedetomidine administration on outcomes in critically ill patients with acute kidney injury: A propensity score-matching analysis.
Topics: Acute Kidney Injury; Critical Illness; Dexmedetomidine; Humans; Intensive Care Units; Propensity Score; Retrospective Studies; Treatment Outcome | 2023 |
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping.
Topics: Acute Kidney Injury; Animals; Constriction; Dexmedetomidine; Epithelial Cells; Interleukin-6; Kidney; Necrosis; Rats; Reperfusion Injury | 2023 |
Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats.
Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Interleukin-6; Kidney; Leukocyte Elastase; Lipocalin-2; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2023 |
Endotoxic kidney injury in Beagle dogs assessed by serum creatinine and symmetric dimethylarginine, and urinary neutrophil gelatinase-associated lipocalin and clusterin.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Biomarkers; Clusterin; Creatinine; Dexmedetomidine; Dog Diseases; Dogs; Endotoxemia; Endotoxins; Kidney; Lipocalin-2; Lipocalins; Proto-Oncogene Proteins; Saline Solution | 2023 |
Impact of dexmedetomidine on mortality in critically ill patients with acute kidney injury: a retrospective propensity score matching analysis.
Topics: Acute Kidney Injury; Critical Illness; Dexmedetomidine; Hospital Mortality; Humans; Intensive Care Units; Propensity Score; Retrospective Studies | 2023 |
Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cytokines; Dexmedetomidine; Drug Evaluation, Preclinical; Escherichia coli; Hemodynamics; Kidney; Norepinephrine; Oxygen; Sepsis; Sheep | 2019 |
The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cytokines; Dexmedetomidine; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Protective Agents; Renal Insufficiency; Retinoblastoma-Binding Protein 2; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Anesthetic preconditioning increases sirtuin 2 gene expression in a renal ischemia reperfusion injury model.
Topics: Acute Kidney Injury; Anesthetics; Animals; Cell Adhesion Molecules; Creatinine; Dexmedetomidine; Gene Expression; Kidney Diseases; Male; Rats; Rats, Wistar; Reperfusion Injury; Sirtuin 2; Sirtuins | 2020 |
Is Dexmedetomidine the Key for Reducing Acute Kidney Injury After Cardiac Surgery?
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Randomized Controlled Trials as Topic | 2020 |
Effects of dexmedetomidine on lipopolysaccharide-induced acute kidney injury in rats and mitochondrial function in cell culture.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cell Culture Techniques; Dexmedetomidine; HEK293 Cells; Humans; Inflammation Mediators; Lipopolysaccharides; Male; Mitochondria; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Treatment Outcome | 2020 |
Dexmedetomidine alleviates cisplatin‑induced acute kidney injury by attenuating endoplasmic reticulum stress‑induced apoptosis via the α2AR/PI3K/AKT pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Biomarkers; Body Weight; Cell Line; Cisplatin; Dexmedetomidine; Endoplasmic Reticulum Stress; Immunohistochemistry; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptors, Adrenergic, alpha-2; Signal Transduction | 2020 |
Dexmedetomidine protects against acute kidney injury in patients with septic shock.
Topics: Acute Kidney Injury; Adult; Aged; Analgesics, Non-Narcotic; China; Cohort Studies; Dexmedetomidine; Female; Humans; Male; Middle Aged; Propofol; Respiration, Artificial; Shock, Septic | 2020 |
Effects of dexmedetomidine pretreatment on rats with sepsis-induced acute kidney injury and miR-146a expression.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Catalase; Creatinine; Dexmedetomidine; Heme Oxygenase (Decyclizing); Interleukin-1beta; Interleukin-6; Kidney; Lipopolysaccharides; Malondialdehyde; MicroRNAs; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sepsis; Superoxide Dismutase | 2020 |
Optimal Interpretation of Trial Sequential Analysis in Understanding the Effect of Dexmedetomidine on Acute Kidney Injury After Cardiac Surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2020 |
It's All in the Details: Dexmedetomidine and Acute Kidney Injury After Cardiac Surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2020 |
Dexmedetomidine ameliorates renal ischemia reperfusion-mediated activation of the NLRP3 inflammasome in alveolar macrophages.
Topics: Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; Cell Line; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Ischemia; Macrophages, Alveolar; NADPH Oxidase 4; Nitric Oxide Synthase Type III; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger | 2020 |
Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway.
Topics: Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Blotting, Western; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labeling; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Random Allocation; Sepsis; Signal Transduction; Spleen; Splenectomy | 2021 |
Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study.
Topics: Acute Kidney Injury; Aged; Analgesics, Opioid; Arthroplasty, Replacement; Cohort Studies; Dexmedetomidine; Female; Humans; Infusions, Intravenous; Male; Postoperative Period; Retrospective Studies | 2020 |
[Effect of dexmedetomidine on expression of tight junction protein ZO-1 in kidney tissue of rats with acute kidney injury induced by sepsis].
Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Kidney; Male; Rats; Rats, Sprague-Dawley; Sepsis; Zonula Occludens-1 Protein | 2020 |
Renoprotective effect of intraoperative dexmedetomidine in pediatric cardiac surgery patients: Comment.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Child; Dexmedetomidine; Heart; Humans | 2021 |
Dexmedetomidine Exerts Renal Protective Effect by Regulating the PGC-1α/STAT1/IRF-1 Axis.
Topics: Acute Kidney Injury; Animals; Cell Line; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Humans; Interferon Regulatory Factor-1; Kidney; Mice; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polymerase Chain Reaction; STAT1 Transcription Factor | 2021 |
Use of dexmedetomidine to attenuate acute kidney injury after cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2017 |
Use of a meta-analysis to assess the preventive effect of dexmedetomidine on cardiac surgery-associated acute kidney injury.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2018 |
Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Cellular Senescence; Dexmedetomidine; Fibrosis; Imidazoles; Inflammation; Isoindoles; Kidney; Male; Mice; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction; Sirolimus | 2018 |
Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Cecal Diseases; Cecum; Cytokines; Dexmedetomidine; Imidazoles; Inflammation; Kidney; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sepsis; Toll-Like Receptor 4 | 2018 |
Dexmedetomidine: the first new kid on the block for preventing cardiac surgery-associated acute kidney injury?
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans | 2018 |
Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway.
Topics: Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Cytoprotection; Dexmedetomidine; Disease Models, Animal; Inflammation Mediators; Kidney Tubules; Lipopolysaccharides; Male; Mice, Inbred C57BL; Sepsis; Signal Transduction; Time Factors | 2018 |
Dexmedetomidine ameliorates lipopolysaccharide-induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK-3β/Nrf2 signaling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Dexmedetomidine; Glycogen Synthase Kinase 3 beta; Inflammation; Kidney Tubules; Lipopolysaccharides; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.
Topics: Acute Kidney Injury; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Humans; Kidney; Lipopolysaccharides; Male; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Sepsis; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4 | 2019 |
The alpha-2 receptor agonist dexmedetomidine attenuates vancomycin‑induced acute kidney injury.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Bacterial Agents; Dexmedetomidine; Rats; Rats, Wistar; Vancomycin; Vasoconstriction | 2019 |
The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis.
Topics: Acute Kidney Injury; Acute Lung Injury; Acute-Phase Proteins; Animals; Apoptosis; Caspase 3; Cecum; Cell Count; Creatinine; Dexmedetomidine; Disease Models, Animal; DNA Fragmentation; Kidney; Lipocalin-2; Lipocalins; Lung; Macrophages, Alveolar; Male; Malondialdehyde; Proto-Oncogene Proteins; Rats; Rats, Wistar; Sepsis | 2013 |
Dexmedetomidine on renal ischemia-reperfusion injury in rats: assessment by means of NGAL and histology.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Kidney Tubules; Lipocalin-2; Lipocalins; Protective Agents; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Treatment Outcome | 2015 |
The Use of Intraoperative Dexmedetomidine Is Not Associated With a Reduction in Acute Kidney Injury After Lung Cancer Surgery.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Dexmedetomidine; Female; Humans; Intraoperative Care; Lung Neoplasms; Male; Middle Aged; Pulmonary Surgical Procedures; Retrospective Studies; Risk Factors; Young Adult | 2016 |
[Pretreatment with dexmedetomidine ameliorates renal inflammation and oxidative stress in rats with lipopolysaccharide-induced sepsis and acute kidney injury].
Topics: Acute Kidney Injury; Animals; Dexmedetomidine; Inflammation; Interleukin-1beta; Kidney; Lipopolysaccharides; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sepsis; Superoxide Dismutase | 2015 |
Dexmedetomidine Inhibits TLR4/NF-κB Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Blood Urea Nitrogen; Cell Line; Creatinine; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; Interleukin-1beta; Liver Transplantation; Male; Microscopy, Confocal; Myeloid Differentiation Factor 88; NF-kappa B; Random Allocation; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA Interference; Signal Transduction; Toll-Like Receptor 4; Transplantation, Autologous; Tumor Necrosis Factor-alpha | 2015 |
Dexmedetomidine Is Associated With Lower Incidence of Acute Kidney Injury After Congenital Heart Surgery.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Cardiac Surgical Procedures; Child, Preschool; Cohort Studies; Dexmedetomidine; Female; Heart Defects, Congenital; Humans; Incidence; Infant; Intensive Care Units, Pediatric; Length of Stay; Male; Respiration, Artificial; Retrospective Studies | 2016 |
Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia/reperfusion injury in rats.
Topics: Actins; Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Blood Urea Nitrogen; Blotting, Western; Creatinine; Dexmedetomidine; HMGB1 Protein; Immunohistochemistry; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Kidney; Male; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Curcumin and dexmedetomidine prevents oxidative stress and renal injury in hind limb ischemia/reperfusion injury in a rat model.
Topics: Acute Kidney Injury; Animals; Antioxidants; Curcumin; Dexmedetomidine; Disease Models, Animal; Extremities; Kidney; Kidney Function Tests; Oxidative Stress; Rats; Reperfusion Injury; Treatment Outcome | 2016 |
Assessing perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Incidence | 2016 |
α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury.
Topics: Actins; Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cells, Cultured; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Endothelium; Focal Adhesion Kinase 1; Humans; Imidazoles; Kidney; Lung; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Adrenergic, alpha-2; Reperfusion Injury; Signal Transduction | 2016 |
Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Cisplatin; Creatinine; Cytokines; Dexmedetomidine; Kidney; Macrophages; Male; Mice, Inbred C57BL; NF-kappa B; Protective Agents; T-Lymphocytes; Tumor Suppressor Protein p53 | 2017 |
Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: a histopathologic study.
Topics: Acute Kidney Injury; Adrenergic alpha-Agonists; Animals; Dexmedetomidine; Kidney Glomerulus; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2009 |
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice.
Topics: Acute Kidney Injury; Animals; Cell Line; Dexmedetomidine; Humans; Male; Mice; Mice, Inbred C57BL; Protective Agents; Reperfusion Injury | 2011 |
α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Animals; Bone Morphogenetic Protein 7; Cell Line; Dexmedetomidine; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Kidney; Mice; Rats; Tumor Necrosis Factor-alpha | 2012 |