Page last updated: 2024-08-24

dexfenfluramine and Pulmonary Hypertension

dexfenfluramine has been researched along with Pulmonary Hypertension in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (25.00)	18.2507
2000's	20 (62.50)	29.6817
2010's	4 (12.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ceulemans, B; Gammaitoni, A; Keane, MG; Lagae, L; Marchau, F; Paelinck, BP; Pringsheim, M; Schoonjans, AS	1
Dempsie, Y; Loughlin, L; MacLean, MR; MacRitchie, NA; Mair, KM; Morecroft, I; Nilsen, M; White, K; Wright, AF	1
Antier, D; Apfeldorfer, CS; Desbuards, N; Hanton, G; Hyvelin, JM; Rochefort, GY; Schenck, E	1
Dempsie, Y; Maclean, MR	1
Girerd, B; Humbert, M; Montani, D; Natali, D; Simonneau, G; Sitbon, O; Soubrier, F	1
Callebert, J; Drouet, L; Etienne, N; Hervé, P; Humbert, M; Launay, JM; Maroteaux, L; Nebigil, CG; Peoc'h, K; Simonneau, G; Tournois, C	1
Rigolin, VH; Seghatol, FF	1
Barst, RJ; Cuervo, N; Deng, Z; Hodge, SE; Humbert, M; Knowles, JA; Moore, KJ; Morse, JH; Simonneau, G; Sitbon, O; Wolf, M	1
Brindley, DN; DeAlmeida, J; Mitani, Y; Mutlu, A; Rabinovitch, M; Russell, JC	1
Gross, SB; Lepor, NE	1
Emery, C; Essener, M; Higenbottam, T; Laude, L	1
Chaouat, A; Coulet, F; Favre, C; Humbert, M; Simonneau, G; Soubrier, F; Weitzenblum, E	1
Hong, Z; Kelly, RF; Lang, IM; Murar, J; Nelson, DP; Rezaie-Majd, S; Varghese, A; Weir, EK	1
Antier, D; Bonnet, P; Eder, V; Hanton, G; Hyvelin, JM; Lemaire, MC; Rochefort, GY	1
MacLean, MR	1
Bader, M; Dempsie, Y; Harmar, A; Herold, N; Loughlin, L; MacLean, MR; MacRitchie, NA; Morecroft, I; Nilsen, M; Peacock, AJ; Welsh, DJ	1
Archer, SL; Dall'ava-Santucci, J; Dinh-Xuan, AT; Djaballah, K; Fartoukh, M; Humbert, M; Mercier, JC; Simonneau, G; Weir, KE	1
Hellermann, J; Salomon, F	1
Cherin, P; Godeau, P; Tellier, P	1
Polak, JM; Radisavljevic, Z; Shroyer, KR; Tuder, RM; Voelkel, NF	1
Adams, C; Cohen, A	1
Kramer, MS; Lane, DA	1
Schultz, S	1
Foreyt, JP; Poston, WS	1
Gross, SB	1
Bíbová, J; Hampl, V	1
Ballmer, PE; Imoberdorf, R	1
Adnot, S; Eddahibi, S; Frisdal, E; Hamon, M; Levame, M; Raffestin, B	1
Michelakis, ED; Weir, EK	1
Morse, JH	1
Bergmann, JF	1

Reviews

10 review(s) available for dexfenfluramine and Pulmonary Hypertension

Article	Year
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population. Current medical research and opinion, 2017, Volume: 33, Issue:10 Topics: Adult; Appetite Depressants; Dexfenfluramine; Epilepsies, Myoclonic; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Incidence; Obesity; Phentermine	2017
The serotonin hypothesis of pulmonary hypertension revisited. Advances in experimental medicine and biology, 2010, Volume: 661 Topics: Animals; Appetite Depressants; Bone Morphogenetic Protein Receptors, Type II; Dexfenfluramine; Endothelial Cells; Humans; Hypertension, Pulmonary; Lung; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Signal Transduction; Vasoconstriction	2010
Appetite suppressants and valvular heart disease. Current opinion in cardiology, 2002, Volume: 17, Issue:5 Topics: Appetite Depressants; Carcinoid Heart Disease; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine; Ultrasonography	2002
Anorexigen-related cardiopulmonary toxicity. Reviews in cardiovascular medicine, 2000,Fall, Volume: 1, Issue:2 Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Echocardiography; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Phentermine	2000
Pulmonary hypertension as a result of drug therapy. Clinics in chest medicine, 2004, Volume: 25, Issue:1 Topics: Appetite Depressants; Dexfenfluramine; Eosinophilia-Myalgia Syndrome; Fenfluramine; Humans; Hypertension, Pulmonary; Iatrogenic Disease; Selective Serotonin Reuptake Inhibitors	2004
Pulmonary hypertension and the serotonin hypothesis: where are we now? International journal of clinical practice. Supplement, 2007, Issue:156 Topics: Dexfenfluramine; Humans; Hypertension, Pulmonary; Potassium Channels; Receptors, Serotonin; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Tryptophan Hydroxylase	2007
Scientific and legal issues in fenfluramine/dexfenfluramine litigation. Texas medicine, 2000, Volume: 96, Issue:2 Topics: Anti-Obesity Agents; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Legislation, Medical; Neurotoxicity Syndromes; Risk Assessment; Science; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Weight Loss	2000
Appetite suppressants and cardiac valvulopathy. Current clinical perspectives. Advance for nurse practitioners, 1999, Volume: 7, Issue:10 Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Nurse Practitioners; Obesity; Phentermine; Practice Guidelines as Topic; Predictive Value of Tests; Prevalence; Risk Factors; Selective Serotonin Reuptake Inhibitors; United States	1999
[Obesity: principles of drug therapy]. Therapeutische Umschau. Revue therapeutique, 2000, Volume: 57, Issue:8 Topics: Aminorex; Anti-Obesity Agents; Appetite Depressants; Chronic Disease; Combined Modality Therapy; Cyclobutanes; Dexfenfluramine; Diet, Reducing; Drug and Narcotic Control; Germany; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Lactones; Obesity; Orlistat; Phentermine	2000
Anorectic drugs and pulmonary hypertension from the bedside to the bench. The American journal of the medical sciences, 2001, Volume: 321, Issue:4 Topics: Aminorex; Appetite Depressants; Dexfenfluramine; Fenfluramine; Humans; Hypertension, Pulmonary; Obesity; Potassium Channels; Serotonin	2001

Other Studies

22 other study(ies) available for dexfenfluramine and Pulmonary Hypertension

Article	Year
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular research, 2013, Jul-01, Volume: 99, Issue:1 Topics: Animals; Arterial Pressure; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cells, Cultured; Cytochrome P-450 CYP1B1; Dexfenfluramine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Familial Primary Pulmonary Hypertension; Female; Hypertension, Pulmonary; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Norfenfluramine; Ovariectomy; Pulmonary Artery; Serotonin; Sex Factors; Tryptophan Hydroxylase; Ventricular Function, Right; Ventricular Pressure	2013
Dexfenfluramine discontinuous treatment does not worsen hypoxia-induced pulmonary vascular remodeling but activates RhoA/ROCK pathway: consequences on pulmonary hypertension. European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3 Topics: Animals; Appetite Depressants; Dexfenfluramine; Enzyme Activation; Female; Gene Expression Regulation; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Weight Gain	2009
Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure. Chest, 2011, Volume: 140, Issue:4 Topics: Appetite Depressants; Comorbidity; Dexfenfluramine; Familial Primary Pulmonary Hypertension; Female; Hamartoma Syndrome, Multiple; Humans; Hypertension, Pulmonary; Middle Aged; Mutation; Pedigree; PTEN Phosphohydrolase; Risk Factors	2011
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nature medicine, 2002, Volume: 8, Issue:10 Topics: Animals; Blood Pressure; Cell Division; Dexfenfluramine; Disease Models, Animal; DNA; Female; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Male; Mice; Organ Culture Techniques; Pulmonary Artery; Pyrimidines; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction	2002
BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. The European respiratory journal, 2002, Volume: 20, Issue:3 Topics: Adolescent; Adult; Aged; Appetite Depressants; Bone Morphogenetic Protein Receptors, Type II; Dexfenfluramine; Female; Fenfluramine; Germ-Line Mutation; Humans; Hypertension, Pulmonary; Male; Middle Aged; Protein Serine-Threonine Kinases; Risk Factors	2002
Dexfenfluramine protects against pulmonary hypertension in rats. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:5 Topics: Animals; Appetite Depressants; Body Weight; Dexfenfluramine; Eating; Endothelium, Vascular; Female; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Monocrotaline; Myocardium; Nitric Oxide Synthase; Obesity; Organ Size; Pancreatic Elastase; Pulmonary Artery; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Vascular Diseases	2002
Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension. Thorax, 2004, Volume: 59, Issue:5 Topics: Adult; Antigens, CD; Dexfenfluramine; Endoglin; Female; Gene Deletion; Germ-Line Mutation; Heterozygote; Humans; Hypertension, Pulmonary; Pedigree; Receptors, Cell Surface; Serotonin Receptor Agonists; Telangiectasia, Hereditary Hemorrhagic; Vascular Cell Adhesion Molecule-1	2004
Increased release of serotonin from rat ileum due to dexfenfluramine. American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 287, Issue:5 Topics: 4-Aminopyridine; Animals; Caffeine; Calcium; Chromatography, High Pressure Liquid; Cytosol; Dexfenfluramine; Fluoxetine; Hypertension, Pulmonary; Ileum; Male; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists	2004
Dexfenfluramine does not worsen but moderates progression of chronic hypoxia-induced pulmonary hypertension. European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3 Topics: Animals; Blood Pressure; Body Weight; Chronic Disease; Dexfenfluramine; Disease Progression; Female; Heart Valve Diseases; Hypertension, Pulmonary; Hypoxia; Lung; Myocardium; Organ Size; Rats; Rats, Wistar; Serotonin Receptor Agonists; Ultrasonography, Doppler; Ventricular Function, Left; Ventricular Function, Right; Weight Gain	2006
Appetite suppressants and pulmonary hypertension: a long-term risk. Prescrire international, 2006, Volume: 15, Issue:85 Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; France; Humans; Hypertension, Pulmonary; Risk Factors	2006
Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. Circulation, 2008, Jun-03, Volume: 117, Issue:22 Topics: Animals; Dexfenfluramine; Hypertension, Pulmonary; Hypoxia; Mice; Mice, Transgenic; p38 Mitogen-Activated Protein Kinases; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Tryptophan Hydroxylase	2008
Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:4 Topics: Adult; Aged; Angina Pectoris; Appetite Depressants; Case-Control Studies; Dexfenfluramine; Disease Susceptibility; Female; Fenfluramine; Free Radical Scavengers; Humans; Hypertension; Hypertension, Pulmonary; Hypoxia; Ischemic Attack, Transient; Lung; Male; Middle Aged; Nitric Oxide; Oxidation-Reduction; Physical Exertion; Prospective Studies; Rest; Vascular Resistance	1998
[Appetite depressants and pulmonary hypertension]. Therapeutische Umschau. Revue therapeutique, 1998, Volume: 55, Issue:9 Topics: Adult; Appetite Depressants; Cesarean Section; Dexfenfluramine; Fatal Outcome; Female; Heart Failure; Humans; Hypertension, Pulmonary; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Third	1998
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?]. La Revue de medecine interne, 1998, Volume: 19, Issue:10 Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Male; Middle Aged; Mitral Valve Insufficiency; Phentermine; Risk Factors	1998
Monoclonal endothelial cells in appetite suppressant-associated pulmonary hypertension. American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:6 Topics: Alleles; Aminorex; Appetite Depressants; Cell Division; Clone Cells; Dexfenfluramine; Endothelium, Vascular; Female; Genetic Predisposition to Disease; Humans; Hypertension, Pulmonary; Lung; Middle Aged; Receptors, Androgen; X Chromosome	1998
[Appetite suppressants and heart valve disorders]. Archives des maladies du coeur et des vaisseaux, 1999, Volume: 92, Issue:9 Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Middle Aged; Mitral Valve Insufficiency; Phentermine; Pulmonary Valve Insufficiency; Serotonin Agents; Serotonin Receptor Agonists	1999
Determining exposure underreporting in pharmacoepidemiologic case-control studies: methods and example. Journal of clinical epidemiology, 1999, Volume: 52, Issue:12 Topics: Adolescent; Adult; Aged; Appetite Depressants; Belgium; Child; Dexfenfluramine; Drug and Narcotic Control; Drug Prescriptions; Drug Utilization; Female; France; Humans; Hypertension, Pulmonary; Incidence; Male; Middle Aged; Models, Statistical; Pharmacoepidemiology; Retrospective Studies; Serotonin Receptor Agonists	1999
A big fat settlement. But lawyers for diet-drug users suggest that $3.75 billion is not nearly enough. U.S. news & world report, 1999, Oct-18, Volume: 127, Issue:15 Topics: Appetite Depressants; Dexfenfluramine; Drug Industry; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Liability, Legal; Serotonin Receptor Agonists; United States	1999
[Anorectics and pulmonary hypertension]. Casopis lekaru ceskych, 2000, Feb-16, Volume: 139, Issue:3 Topics: Appetite Depressants; Dexfenfluramine; Fenfluramine; Humans; Hypertension, Pulmonary; Risk Factors; Selective Serotonin Reuptake Inhibitors	2000
Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Appetite Depressants; Carrier Proteins; Cell Hypoxia; Dexfenfluramine; Hypertension, Pulmonary; Lung; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Thymidine	2001
Bone morphogenetic protein receptor 2 mutations in pulmonary hypertension. Chest, 2002, Volume: 121, Issue:3 Suppl Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Dexfenfluramine; Fenfluramine; Gaucher Disease; Humans; Hypertension, Pulmonary; Mutation; Protein Serine-Threonine Kinases; Risk Factors; Transforming Growth Factor beta	2002
[Facts, fakes and "biblio". Do internists still have something to learn about dexfenfluramine?]. Annales de medecine interne, 2001, Volume: 152, Issue:7 Topics: Dexfenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulmonary; Obesity; Serotonin Antagonists	2001