devazepide and Stress-Disorders--Post-Traumatic

devazepide has been researched along with Stress-Disorders--Post-Traumatic* in 1 studies

Other Studies

1 other study(ies) available for devazepide and Stress-Disorders--Post-Traumatic

Article	Year
Blockade of CCK(B) but not CCK(A) receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder. Behavioral neuroscience, 1997, Volume: 111, Issue:2 Lasting increases in anxiety-like behavior (ALB) in rodents in the elevated plus maze have been reported to follow brief (5 min) exposures to a cat. This study examined the role of CCK(A) and CCK(B) receptors in lasting increases in ALB following exposure to a cat. Block of CCK(B) receptors 30 min before and after cat exposure prevented increases in ALB assessed 1 week later in the elevated plus maze. Blocks of CCK(A) receptors either before or after cat exposure were without effect on increases in ALB measured 1 week later. Changes in activity or exploration could not account for the results. Effects of cat exposure on ALB, startle, and corticosteroid levels have been proposed as a model of affective disorder in posttraumatic stress disorder (PTSD). Implications of these findings for mechanisms of initiation of anxiety in PTSD and posttrauma pharmacological prophylaxis in PTSD are discussed. Topics: Agonistic Behavior; Animals; Anxiety; Arousal; Benzodiazepinones; Cats; Devazepide; Dose-Response Relationship, Drug; Escape Reaction; Fear; Indoles; Male; Maze Learning; Meglumine; Predatory Behavior; Pyrazoles; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Reflex, Startle; Retention, Psychology; Stress Disorders, Post-Traumatic	1997

Article

Year

Blockade of CCK(B) but not CCK(A) receptors before and after the stress of predator exposure prevents lasting increases in anxiety-like behavior: implications for anxiety associated with posttraumatic stress disorder.

Behavioral neuroscience, 1997, Volume: 111, Issue:2

Lasting increases in anxiety-like behavior (ALB) in rodents in the elevated plus maze have been reported to follow brief (5 min) exposures to a cat. This study examined the role of CCK(A) and CCK(B) receptors in lasting increases in ALB following exposure to a cat. Block of CCK(B) receptors 30 min before and after cat exposure prevented increases in ALB assessed 1 week later in the elevated plus maze. Blocks of CCK(A) receptors either before or after cat exposure were without effect on increases in ALB measured 1 week later. Changes in activity or exploration could not account for the results. Effects of cat exposure on ALB, startle, and corticosteroid levels have been proposed as a model of affective disorder in posttraumatic stress disorder (PTSD). Implications of these findings for mechanisms of initiation of anxiety in PTSD and posttrauma pharmacological prophylaxis in PTSD are discussed.

Topics: Agonistic Behavior; Animals; Anxiety; Arousal; Benzodiazepinones; Cats; Devazepide; Dose-Response Relationship, Drug; Escape Reaction; Fear; Indoles; Male; Maze Learning; Meglumine; Predatory Behavior; Pyrazoles; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Reflex, Startle; Retention, Psychology; Stress Disorders, Post-Traumatic

1997