devazepide has been researched along with Cerebrovascular-Disorders* in 1 studies
1 other study(ies) available for devazepide and Cerebrovascular-Disorders
| Article | Year |
|---|---|
CCKB receptor activation protects CA1 neurons from ischemia-induced dysfunction in stroke-prone spontaneously hypertensive rats hippocampal slices.
We examined the effect of cholecystokinin octapeptide sulfated type (CCK-8S) on dysfunction of CA1 pyramidal neurons induced by in vitro ischemic insult in hippocampal slices of stroke-prone spontaneously hypertensive rats (SHRSP). CCK-8S shortened the time required for partial recovery from block of a population spike produced by ischemia. Furthermore, CCK-8S reduced ischemic insult-induced accumulation of K+ in extracellular space. Suppression of the K+ conductance by the CCKB receptor activation is suggested to contribute to neuroprotection by CCK-8S. Topics: Animals; Benzodiazepinones; Brain Ischemia; Cerebrovascular Disorders; Devazepide; Electrophysiology; Hippocampus; In Vitro Techniques; Male; Neurons; Potassium; Rats; Rats, Inbred SHR; Receptors, Cholecystokinin; Sincalide | 1995 |