desoxyepothilone-b and Leukemia--T-Cell

desoxyepothilone-b has been researched along with Leukemia--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for desoxyepothilone-b and Leukemia--T-Cell

Article	Year
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. Journal of natural products, 2002, Volume: 65, Issue:7 A new epothilone, 10,11-didehydroepothilone D (5), was isolated from a strain of the heterologous host Myxococcus xanthus genetically engineered to produce epothilone D (4). The structure of 5 was determined from NMR and MS data. The epothilone polyketide synthase was further modified in a recombinant M. xanthus strain to produce 5 as the major epothilone-related metabolite. The cytotoxicity of 5 against a panel of tumor cell lines, including several with multidrug resistance, and its effect on tubulin polymerization were comparable to epothilone D (4). Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Female; Genetic Engineering; Glioma; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lung Neoplasms; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Myxococcus xanthus; Nuclear Magnetic Resonance, Biomolecular; Thiazoles; Tubulin; Tumor Cells, Cultured	2002

Article

Year

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.

Journal of natural products, 2002, Volume: 65, Issue:7

A new epothilone, 10,11-didehydroepothilone D (5), was isolated from a strain of the heterologous host Myxococcus xanthus genetically engineered to produce epothilone D (4). The structure of 5 was determined from NMR and MS data. The epothilone polyketide synthase was further modified in a recombinant M. xanthus strain to produce 5 as the major epothilone-related metabolite. The cytotoxicity of 5 against a panel of tumor cell lines, including several with multidrug resistance, and its effect on tubulin polymerization were comparable to epothilone D (4).

Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Female; Genetic Engineering; Glioma; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lung Neoplasms; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Myxococcus xanthus; Nuclear Magnetic Resonance, Biomolecular; Thiazoles; Tubulin; Tumor Cells, Cultured

2002