desoxycorticosterone has been researched along with Cirrhosis in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.36) | 18.2507 |
| 2000's | 30 (53.57) | 29.6817 |
| 2010's | 20 (35.71) | 24.3611 |
| 2020's | 3 (5.36) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y; Guo, X; Liang, H; Liu, B; Nie, J; Wen, S; Yu, W; Zou, H | 1 |
| Cui, Z; Gao, Y; Liang, H; Liu, B; Nie, J; Song, J; Wen, S; Yu, W | 1 |
| Bienvenu, LA; Clyne, CD; Delbridge, LMD; Fletcher, EK; Fuller, PJ; Kennaway, DR; Morgan, J; Rickard, AJ; Young, MJ | 1 |
| Cai, L; Chen, C; Li, H; Lu, C; Qian, Y; Tan, Y; Weng, H | 1 |
| Fan, B; Li, Q; Ma, L; Wang, L; Wu, J; Zhou, J | 2 |
| Fuller, PJ; Morgan, J; Shen, JZ; Tesch, GH; Young, MJ | 1 |
| Chrissobolis, S; Miller, AA; Morgan, J; Rickard, AJ; Sobey, CG; Young, MJ | 1 |
| Chrissobolis, S; Drummond, GR; Fuller, PJ; Morgan, J; Rickard, AJ; Shen, JZ; Tesch, GH; Young, MJ | 1 |
| He, L; Hu, Z; Liang, H; Ma, Z; Peng, H; Wang, Y | 1 |
| Hisamichi, M; Hoshino, S; Ichikawa, D; Kamijo-Ikemori, A; Kimura, K; Natsuki, T; Shibagaki, Y; Sugaya, T | 1 |
| Aicher, WK; Alexander, D; Artunc, F; Friedrich, B; Janessa, A; Lang, F; Müller, GA; Risler, T | 1 |
| Dorrance, AM | 1 |
| Fuller, PJ; Funder, JW; Morgan, J; Rickard, AJ; Tesch, G; Young, MJ | 1 |
| Jadhav, A; Ndisang, JF | 1 |
| Brown, L; Fairlie, DP; Fenning, A; Halili, MA; Iyer, A; Le, GT; Lim, J; Reid, RC | 1 |
| Chen, R; Eisner, C; Hu, X; Huang, Y; Kopp, JB; Leelahavanichkul, A; Mizel, D; Schnermann, J; Star, RA; Wright, EC; Yan, Q; Yuen, PS; Zhou, H | 1 |
| Brown, L; Chan, V; Fenning, A; Hoey, A; Iyer, A | 1 |
| Furuichi, K; Kaneko, S; Kitagawa, K; Matsushima, K; Mukaida, N; Sakai, N; Shimizu, K; Wada, T | 1 |
| Chin-Dusting, J; Chu, PY; Du, XJ; Kaye, DM; Kiriazis, H; Marshall, T; Zatta, A | 1 |
| Wang, DH; Wang, Y | 1 |
| Fujisawa, G; Hirahara, I; Iwazu, Y; Kusano, E; Muto, S; Takeda, S | 1 |
| He, L; Hua, J; Li, Q; Ma, L; Yu, J; Zhou, J | 1 |
| Bienvenu, LA; Cranston, GA; Delbridge, LM; Fletcher, EK; Morgan, J; Reichelt, ME; Rickard, AJ; Shen, JZ; Young, MJ | 1 |
| Chen, HW; Feng, KF; He, LF; Hu, H; Hua, JS; Li, Q; Ma, LK; Wang, L; Yu, H; Zhou, JL | 1 |
| Dieterich, M; Gögebakan, O; Kossmehl, P; Kreutz, R; Rothermund, L; Vetter, R; Yagil, C; Yagil, Y | 1 |
| Funder, JW | 1 |
| Dilley, R; Funder, JW; Moussa, L; Young, MJ | 1 |
| Fujisawa, G; Fujita, N; Ishibashi, S; Itabashi, N; Kusano, E; Muto, S; Okada, K | 1 |
| Amiri, F; Diep, QN; Iglarz, M; Paradis, P; Schiffrin, EL; Touyz, RM; Viel, EC | 1 |
| Funder, J; Young, M | 1 |
| Funder, JW; Young, M | 1 |
| Irukayama-Tomobe, Y; Miyauchi, T; Ogata, T; Sakai, S; Takanashi, M; Yamaguchi, I | 1 |
| Hirade, S; Inoue, H; Kagitani, S; Takahashi, T; Takata, M; Ueno, H | 1 |
| Perlini, S | 1 |
| Amiri, F; Gannon, P; Pu, Q; Schiffrin, EL | 1 |
| Bledsoe, G; Chao, J; Chao, L; Xia, CF | 1 |
| Grobe, JL; Katovich, MJ; Mao, H; Mecca, AP | 1 |
| Belaiba, RS; Berchtold, S; Dalton, ND; Daut, J; Flögel, U; Friedrich, B; Görlach, A; Grahammer, F; Huang, DY; Hussain, A; Kandolf, R; Klingel, K; Kuhl, D; Lang, F; Osswald, H; Ross, J; Schrader, J; Vallon, V; Wulff, P; Wyatt, AW | 1 |
| Fuller, PJ; Funder, JW; Lam, EY; Nikolic-Paterson, DJ; Young, MJ | 1 |
| Brown, L; Hoey, A; Levick, S; Loch, D | 1 |
| Brown, L; Hoey, A; Loch, D | 1 |
| Fuller, PJ; Funder, JW; Rickard, AJ; Young, MJ | 1 |
| Fuller, PJ; Funder, JW; Morgan, J; Rickard, AJ; Young, MJ | 1 |
| Fujisawa, G; Ishibashi, S; Iwazu, Y; Kusano, E; Muto, S; Nakazawa, E; Okada, K | 1 |
| Bernhardt, R; Carapito, C; Hwang, KH; Leize-Wagner, E; Van Dorsselaer, A; Wilzewski, B; Zöllner, S | 1 |
| Funder, J; Head, G; Young, M | 1 |
| Clozel, JP; Clozel, M; Gonzales, MF; Hess, P; Heudes, D; Karam, H; Löffler, BM | 1 |
| Border, WA; Noble, NA | 1 |
| Chao, J; Chao, L; Dobrzynski, E; Wang, C | 1 |
| Ammarguellat, F; Larouche, I; Schiffrin, EL | 1 |
| Dilley, R; Fujisawa, G; Fullerton, MJ; Funder, JW | 1 |
| Brown, L; Fenning, A; Margolin, SB; Mirkovic, S; Seymour, AM; Strachan, A; Taylor, SM | 1 |
| Amiri, F; Ammarguellat, FZ; Gannon, PO; Schiffrin, EL | 1 |
| Cordasic, N; Hartner, A; Hilgers, KF; Klanke, B; Müller, U; Sterzel, RB | 1 |
2 review(s) available for desoxycorticosterone and Cirrhosis
| Article | Year |
|---|---|
New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone.
Topics: Aldosterone; Animals; Cardiomegaly; Clinical Trials as Topic; Desoxycorticosterone; Eplerenone; Fibrosis; Heart; Heart Failure; Humans; Hypertension; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Receptors, Mineralocorticoid; Spironolactone | 2002 |
TGF-beta in kidney fibrosis: a target for gene therapy.
Topics: Animals; Desoxycorticosterone; Diabetic Nephropathies; Fibrosis; Genetic Therapy; Glomerulonephritis; Graft Rejection; Humans; Kidney; Kidney Transplantation; Transforming Growth Factor beta | 1997 |
54 other study(ies) available for desoxycorticosterone and Cirrhosis
| Article | Year |
|---|---|
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
Topics: Acetates; Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Hypertension, Renal; Inflammation; Interferon Regulatory Factors; Kidney; Mice; Mice, Knockout | 2023 |
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Hypertension, Renal; Inflammation; Kidney; Macrophages; Mice; Mice, Inbred C57BL | 2023 |
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension: Erratum.
Topics: Acetates; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Humans; Hypertension; Inflammation; Interferon Regulatory Factors; Kidney; Nephritis | 2023 |
Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice.
Topics: Animals; Cells, Cultured; CLOCK Proteins; Desoxycorticosterone; Fibrosis; Heart; Male; Mice; Mice, Inbred CBA; Mice, Transgenic; Myocarditis; Myocardium; Rats; Receptors, Mineralocorticoid; Signal Transduction; Sodium Chloride | 2017 |
Urinary miR-21 as a potential biomarker of hypertensive kidney injury and fibrosis.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Biomarkers; Creatinine; Desoxycorticosterone; Fibrosis; Hypertension; Hypertension, Renal; Kidney; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Urinary Tract | 2017 |
Correlation between platelet-derived growth factor signaling pathway and inflammation in desoxycorticosterone-induced salt-sensitive hypertensive rats with myocardial fibrosis.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Fibrosis; Hypertension; Male; Myocarditis; Myocardium; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Signal Transduction; Sodium Chloride, Dietary | 2013 |
Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone; Disease Models, Animal; Fibroblasts; Fibrosis; Hypertension; Immunohistochemistry; Male; Mineralocorticoids; Myofibroblasts; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2014 |
CCL2-dependent macrophage recruitment is critical for mineralocorticoid receptor-mediated cardiac fibrosis, inflammation, and blood pressure responses in male mice.
Topics: Animals; Blood Pressure; Chemokine CCL2; Collagen; Cytokines; Desoxycorticosterone; Fibroblasts; Fibrosis; Immunohistochemistry; Inflammation; Macrophages; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardium; Radioimmunoassay; Receptors, Mineralocorticoid; Time Factors | 2014 |
Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure.
Topics: Aldosterone; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cells, Cultured; Connective Tissue Growth Factor; Desoxycorticosterone; Disease Models, Animal; Endothelium, Vascular; Fibrosis; Humans; Hypertension; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Myocarditis; Receptors, Mineralocorticoid; Sodium Chloride; Vascular Resistance; Ventricular Remodeling | 2014 |
Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages.
Topics: Animals; Cells, Cultured; Desoxycorticosterone; Fibrosis; Heart; Inflammation; Macrophages; Male; Mice; Mice, Transgenic; Myocardium; Receptors, Mineralocorticoid; Signal Transduction; Sodium Chloride, Dietary; T-Lymphocytes; Ventricular Remodeling | 2016 |
CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Chemokine CXCL16; Desoxycorticosterone; Fibrosis; Hypertension, Renal; Mice; Mice, Knockout; Sodium Chloride, Dietary | 2016 |
Role of angiotensin II type 1a receptor in renal injury induced by deoxycorticosterone acetate-salt hypertension.
Topics: Animals; Desoxycorticosterone; Fatty Acid-Binding Proteins; Female; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Kidney Diseases; Low Density Lipoprotein Receptor-Related Protein-2; Mice; Mice, Knockout; Mice, Transgenic; Receptor, Angiotensin, Type 1; Sodium Chloride | 2017 |
DOCA and TGF-beta induce early growth response gene-1 (Egr-1) expression.
Topics: Animals; Cell Line; Desoxycorticosterone; Disease Models, Animal; Early Growth Response Protein 1; Fibrosis; Gene Expression Regulation; Humans; Kidney Diseases; Mice; Sodium Chloride; Time Factors; Transfection; Transforming Growth Factor beta | 2008 |
Are macrophages the foot soldiers in the war waged by aldosterone against the heart?
Topics: Aldosterone; Animals; Blood Pressure; Desoxycorticosterone; Fibrosis; Macrophages; Mice; Mice, Knockout; Models, Biological; Monocytes; Myocardium; Receptors, Mineralocorticoid; Sodium Chloride, Dietary | 2009 |
Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Pressure; Chemokine CCL2; Collagen; Desoxycorticosterone; Female; Fibrosis; Gene Expression; Immunohistochemistry; Macrophages; Male; Mice; Mice, Knockout; Monocytes; Myocardium; Nephrectomy; Plasminogen Activator Inhibitor 1; Random Allocation; Receptors, Mineralocorticoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Chloride, Dietary | 2009 |
The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension.
Topics: Adiponectin; Animals; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Fibrosis; Glucose; Heme Oxygenase (Decyclizing); Hemin; Hypertension; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Necrosis; Oxidative Stress; Pancreas; Rats; Rats, Sprague-Dawley; Signal Transduction | 2010 |
Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.
Topics: Animals; Desoxycorticosterone; Fibrosis; Heart; Histone Deacetylase Inhibitors; Hydroxamic Acids; Hypertension; Male; Rats; Rats, Wistar; Vorinostat | 2010 |
Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model.
Topics: Albuminuria; Anemia; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Chronic Disease; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Fibrosis; Genetic Predisposition to Disease; Glomerulonephritis; Heart Diseases; Hydralazine; Hypertension; Imidazoles; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney; Kidney Diseases; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Nephrectomy; Sodium Chloride, Dietary; Species Specificity; Telemetry; Tetrazoles; Time Factors; X-Ray Microtomography | 2010 |
Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Desoxycorticosterone; Fibrosis; Heart; Heart Ventricles; Humans; Hypertension; Male; Mineralocorticoids; Rats; Rats, Wistar; Resveratrol; Sodium Chloride, Dietary; Stilbenes; Ventricular Remodeling | 2011 |
Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney.
Topics: Animals; Antigens, Differentiation; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Desoxycorticosterone; Fibrosis; Hypertension; Kidney; Macrophages; Male; Mice; Mice, Inbred C57BL; Receptors, Chemokine; Signal Transduction; Transforming Growth Factor beta1 | 2011 |
CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess.
Topics: Animals; Chemokine CXCL12; Desoxycorticosterone; Disease Models, Animal; Fibrosis; Heart; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; Mice; Mice, Inbred C57BL; Mineralocorticoids; Myocardium; Pyridines; Receptors, CXCR4; Signal Transduction; Up-Regulation | 2011 |
Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-β/Smad signaling in DOCA-salt hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Fibronectins; Fibrosis; Heart Rate; Hypertension; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Mice; Phosphorylation; Protective Agents; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Time Factors; Transforming Growth Factor beta; TRPV Cation Channels | 2011 |
Matrix metalloproteinase 2 induces epithelial-mesenchymal transition in proximal tubules from the luminal side and progresses fibrosis in mineralocorticoid/salt-induced hypertensive rats.
Topics: Animals; Collagen; Desoxycorticosterone; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Epithelial-Mesenchymal Transition; Fibrosis; Hypertension; Kidney; Kidney Tubules, Proximal; Male; Matrix Metalloproteinase 2; Nephrectomy; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone | 2011 |
Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism.
Topics: Amides; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cardiomyopathies; Cardiotonic Agents; Collagen; Desoxycorticosterone; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fumarates; Heart Ventricles; Indicators and Reagents; Male; Matrix Metalloproteinase 9; Myocardium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Renin | 2012 |
Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis.
Topics: Animals; Desoxycorticosterone; Fibrosis; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; Receptors, Mineralocorticoid; Sodium Chloride, Dietary; Ventricular Remodeling | 2012 |
Imatinib attenuates myocardial fibrosis in association with inhibition of the PDGFRα activity.
Topics: Animals; Benzamides; Blood Pressure; Blotting, Western; Desoxycorticosterone; Disease Models, Animal; Endomyocardial Fibrosis; Fibronectins; Fibrosis; Hypertension; Imatinib Mesylate; Male; Nephrectomy; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha; Receptor, Platelet-Derived Growth Factor beta; Tenascin; Treatment Outcome | 2012 |
Endothelin-A receptor blockade prevents left ventricular hypertrophy and dysfunction in salt-sensitive experimental hypertension.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Calcium-Binding Proteins; Calcium-Transporting ATPases; Desoxycorticosterone; Disease Models, Animal; Endothelin Receptor Antagonists; Fibrosis; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Male; Organ Size; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred Strains; Receptor, Endothelin A; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium Chloride; Ventricular Dysfunction, Left | 2002 |
Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Blood Pressure; Carbenoxolone; Cardiomegaly; Coronary Disease; Desoxycorticosterone; Enzyme Inhibitors; Eplerenone; Fibrosis; Heart; Hydroxysteroid Dehydrogenases; Kidney; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Myocardium; Nephrectomy; Organ Size; Rats; Rats, Sprague-Dawley; Sodium Chloride; Solutions; Spironolactone; Vasculitis | 2003 |
Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.
Topics: Animals; Blood Pressure; Cardiomegaly; Collagen; Desoxycorticosterone; Fibrosis; Guanidines; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sodium-Hydrogen Exchangers; Spironolactone; Sulfones | 2003 |
Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Collagen; Desoxycorticosterone; Endothelin-1; Endothelins; Fenofibrate; Fibrosis; Heart; Heart Ventricles; Hypertension; Myocardium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Ventricular Remodeling | 2003 |
Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis.
Topics: Animals; Anti-Arrhythmia Agents; Canrenoic Acid; Desoxycorticosterone; Fibrosis; Guanidines; Heart Diseases; Hydrogen; Male; Mineralocorticoid Receptor Antagonists; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers; Sulfones; Vasculitis | 2003 |
Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats.
Topics: Animals; Biomarkers; Coronary Vessels; Desoxycorticosterone; Eplerenone; Fibrosis; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sodium Chloride, Dietary; Spironolactone; Vasculitis | 2004 |
Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with
Topics: Animals; Blotting, Western; Cardiac Output, Low; Desoxycorticosterone; Diastole; Fenofibrate; Fibrosis; Gene Expression; Hemodynamics; Hypertension; Hypolipidemic Agents; I-kappa B Proteins; Male; Myocardium; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride; Transcription Factors | 2004 |
Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Weight; Cardiomegaly; Chemokine CCL2; Collagen Type I; Collagen Type III; Desoxycorticosterone; Fibrosis; Hypertension; Interleukin-6; Macrophages; Male; Monocytes; Myocardium; Nephrectomy; Organ Size; ortho-Aminobenzoates; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride, Dietary; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
The potential advantage of omapatrilat: dual anti-fibrotic and anti-inflammatory effects in one single molecule.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Cell Adhesion Molecules; Desoxycorticosterone; Drug Therapy, Combination; Fibrosis; Heart Diseases; Hypertension; Inflammation; Kidney Diseases; Metalloendopeptidases; Neprilysin; Organophosphonates; Pyridines; Rats; Thiazepines | 2005 |
Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Cell Adhesion Molecules; Collagen; Desoxycorticosterone; Drug Therapy, Combination; Enalapril; Fibrosis; Heart Diseases; Hypertension; Inflammation; Kidney Diseases; Metalloendopeptidases; Neprilysin; NF-kappa B; Organophosphonates; Pyridines; Rats; Rats, Sprague-Dawley; Thiazepines | 2005 |
Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats.
Topics: Animals; Cell Cycle Proteins; Cell Division; Cyclic GMP; Cyclin-Dependent Kinase Inhibitor p27; Desoxycorticosterone; Disease Models, Animal; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Hypertension, Renal; Hypertrophy; JNK Mitogen-Activated Protein Kinases; Kallikreins; Male; Nitrates; Oxidative Stress; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Suppressor Proteins | 2005 |
Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension.
Topics: Angiotensin I; Animals; Blood Pressure; Cardiomegaly; Collagen; Coronary Vessels; Desoxycorticosterone; Dose-Response Relationship, Drug; Fibrosis; Heart Diseases; Hypertension; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2006 |
SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment.
Topics: Angiotensins; Animals; Blood Pressure; Connective Tissue Growth Factor; Desoxycorticosterone; Fibrosis; Heart; Heart Diseases; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Mutant Strains; Mineralocorticoid Receptor Antagonists; Myocardium; NF-kappa B; Protein Serine-Threonine Kinases; Receptors, Mineralocorticoid; Salts; Spironolactone | 2006 |
Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats.
Topics: Animals; Collagen; Cyclooxygenase 2; Desoxycorticosterone; Fibrosis; Heme Oxygenase-1; Inflammation; Kidney; Male; Osteopontin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Sialoglycoproteins; Steroids | 2006 |
Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Desoxycorticosterone; Fibrosis; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypertrophy; Male; Myocardium; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sodium Chloride, Dietary; Sulfonamides; Ventricular Remodeling | 2006 |
Attenuation of cardiovascular remodeling in DOCA-salt rats by the vasopeptidase inhibitor, omapatrilat.
Topics: Action Potentials; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Fibrosis; Heart Ventricles; Hypertension; Hypertrophy; Inflammation; Male; Membrane Potentials; Metalloendopeptidases; Myocardial Contraction; Papillary Muscles; Pyridines; Rats; Rats, Wistar; Sodium Chloride, Dietary; Thiazepines; Ventricular Remodeling | 2006 |
The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Fibrosis; Inflammation Mediators; Male; Mifepristone; Mineralocorticoids; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Sodium Chloride, Dietary | 2006 |
Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
Topics: Animals; Biomarkers; Blood Pressure; Cardiomegaly; Cardiomyopathies; Coronary Vessels; Desoxycorticosterone; Drug Administration Schedule; Eplerenone; Fibrosis; Hormone Antagonists; Male; Mifepristone; Myocardium; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Signal Transduction; Sodium Chloride; Spironolactone; Vasculitis | 2007 |
Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.
Topics: Animals; Apoptosis; Capillaries; Connective Tissue Growth Factor; Desoxycorticosterone; Endothelium, Vascular; Fibrosis; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Male; Mineralocorticoid Receptor Antagonists; Nephritis, Interstitial; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spironolactone; Thrombospondin 1; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2008 |
Aldosterone: from biosynthesis to non-genomic action onto the proteome.
Topics: Adrenal Glands; Aldosterone; Animals; Calcium; Corticosterone; Cytochrome P-450 CYP11B2; Desoxycorticosterone; Fibrosis; Genome; Hormones; Humans; Models, Biological; Proteome; Proteomics; Steroids | 2008 |
Determinants of cardiac fibrosis in experimental hypermineralocorticoid states.
Topics: Adrenalectomy; Aldosterone; Animals; Desoxycorticosterone; Drug Combinations; Fibrosis; Fludrocortisone; Heart; Hormone Antagonists; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Myocardium; Nephrectomy; Potassium; Rats; Rats, Sprague-Dawley; Spironolactone | 1995 |
Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Bosentan; Calcium Channel Blockers; Cardiomegaly; Collagen; Coronary Circulation; Desoxycorticosterone; Enalapril; Endothelin Receptor Antagonists; Fibrosis; Hypertension; Male; Mibefradil; Myocardium; Perfusion; Rats; Rats, Wistar; Sulfonamides; Tetrahydronaphthalenes | 1996 |
Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Adenoviridae; Adrenomedullin; Animals; Cardiomegaly; Cyclic AMP; Cyclic GMP; Desoxycorticosterone; Disease Models, Animal; Fibrosis; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Hypertension; Kidney Diseases; Male; Peptides; Rats; Rats, Sprague-Dawley; Systole | 2000 |
Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism.
Topics: Animals; Atrasentan; Blood Pressure; Collagen; Collagen Type I; Desoxycorticosterone; Endothelin A Receptor Antagonists; Fibrosis; Hypertension; Male; Myocardium; Organ Size; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Chloride; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Experimental cardiac fibrosis: differential time course of responses to mineralocorticoid-salt administration.
Topics: Animals; Blood Pressure; Cardiomyopathies; Collagen; Desoxycorticosterone; Fibrosis; Heart; Male; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors | 2001 |
Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats.
Topics: Amiloride; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Biological Availability; Collagen; Desoxycorticosterone; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Norepinephrine; Pyridones; Rats; Rats, Wistar; Sodium Chloride, Dietary; Vasoconstrictor Agents | 2002 |
Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors.
Topics: Animals; Desoxycorticosterone; Fibrosis; Heart Diseases; Hypertension; Male; Matrix Metalloproteinases; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Ventricular Remodeling | 2002 |
The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease.
Topics: Animals; Capillaries; Desoxycorticosterone; Fibrosis; Hypertension, Renal; Integrin alpha Chains; Integrins; Kidney Glomerulus; Mice | 2002 |