desoxycorticosterone acetate has been researched along with Hypertension in 218 studies
Desoxycorticosterone Acetate: The 21-acetate derivative of desoxycorticosterone.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study demonstrated the protective effect of resveratrol and exercise on hypertension-induced cardiac dysfunction by modulating cellular stress responses including oxidative stress, ER stress, mitophagy, NLRP3 inflammasome-mediated inflammation, and mitogenic activation." | 8.12 | Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses. ( Bal, NB; Bostanci, A; Demirel-Yilmaz, E; Dönmez, MO; Sadi, G; Uludag, MO, 2022) |
| "T cells participate in angiotensin II (Ang II)-induced hypertension." | 7.80 | Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension. ( Benndorf, RA; Ehmke, H; Krebs, CF; Lange, S; Lehners, A; Meyer-Schwesinger, C; Niemann, G; Panzer, U; Paust, HJ; Rosendahl, A; Stahl, RA; Velden, J; Wenzel, UO, 2014) |
| "Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation." | 5.91 | Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice. ( Broughton, BRS; de Veer, M; Li, Y; Ricardo, SD; Salimova, E; Samuel, CS; Zheng, G, 2023) |
| "Equol-treated DHRs showed a significant decrease in both the swimming distance and time required to reach the escape platform (78." | 5.43 | Effects of equol on deoxycorticosterone acetate salt-induced hypertension and associated vascular dementia in rats. ( Liu, TH; Tsai, TY, 2016) |
| "Hypertension was induced by using the deoxycorticosterone acetate (DOCA)-induced (15 mg/kg twice per week, subcutaneously) salt-sensitive hypertension model of Wistar rats." | 5.42 | Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension. ( Akcali, KC; Ayaloglu-Butun, F; Demirel-Yilmaz, E; Han, S; Uludag, MO; Usanmaz, SE, 2015) |
| "This sustained hypertension is not due to any anatomical fault in the kidney and in that sense is not primarily renal in origin." | 5.23 | Sustained hypertension following the administration of desoxycorticosterone acetate. ( FRIEDMAN, CL; FRIEDMAN, SM; NAKASHIMA, M, 1951) |
| "Endogenous ouabain (EO) increases in some patients with hypertension and in rats with volume-dependent hypertension." | 4.31 | Small artery remodeling and stiffening in deoxycorticosterone acetate-salt hypertensive rats involves the interaction between endogenous ouabain/Na + K + -ATPase/cSrc signaling. ( Castro, MM; Couto, GK; Ishikawa, FM; Parente, JM; Rossoni, LV; Tomazelli, CA; Xavier, FE, 2023) |
| "Our study demonstrated the protective effect of resveratrol and exercise on hypertension-induced cardiac dysfunction by modulating cellular stress responses including oxidative stress, ER stress, mitophagy, NLRP3 inflammasome-mediated inflammation, and mitogenic activation." | 4.12 | Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses. ( Bal, NB; Bostanci, A; Demirel-Yilmaz, E; Dönmez, MO; Sadi, G; Uludag, MO, 2022) |
| "Hypertension induced hypoinsulinemia with concomitant lack of significant changes in glycemia, reduced intramyocardial glycogen content and increased pyruvate dehydrogenase (PDH) expression in the cardiac muscle." | 3.88 | The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension. ( Chabowski, A; Harasim-Symbor, E; Kasacka, I; Lewandowska, A; Malinowska, B; Polak, A, 2018) |
| "We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and the development of deoxycorticosterone acetate (DOCA)-salt hypertension." | 3.81 | Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension. ( Feng, Y; Li, W; Speth, RC; Sullivan, MN; Worker, CJ; Xiong, Z; Zhang, S, 2015) |
| " Captopril and losartan were able to reduce rupture rate without affecting systemic hypertension induced by DOCA-salt treatment." | 3.80 | Roles of hypertension in the rupture of intracranial aneurysms. ( Hashimoto, T; Kitazato, KT; Kudo, M; Liang, EI; Makino, H; Murakami, S; Nagahiro, S; Shimada, K; Tada, Y; Wada, K, 2014) |
| "T cells participate in angiotensin II (Ang II)-induced hypertension." | 3.80 | Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension. ( Benndorf, RA; Ehmke, H; Krebs, CF; Lange, S; Lehners, A; Meyer-Schwesinger, C; Niemann, G; Panzer, U; Paust, HJ; Rosendahl, A; Stahl, RA; Velden, J; Wenzel, UO, 2014) |
| "This study reports the critical role of endogenous ouabain in volume-dependent hypertension." | 3.80 | Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway. ( Rossoni, LV; Wenceslau, CF, 2014) |
| "DOCA-salt was characterized by increased blood pressure, decreased renal function, increased proteinuria, increased glomerulosclerosis and tubulointerstitial fibrosis with myofibroblast accumulation, increased renal endothelin-1 levels and RhoA activity along with increased expression of connective tissue growth factor at both mRNA and protein levels as compared with uninephrectomized control male Wistar rats." | 3.80 | Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats. ( Chang, NC; Chung, TH; Lee, TM; Lin, SZ, 2014) |
| "We analysed the chronic effects of the peroxisome proliferator-activated receptor β/δ (PPAR-β) agonist GW0742 on the renin-independent hypertension induced by deoxycorticosterone acetate (DOCA)-salt." | 3.79 | Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension. ( Duarte, J; Gómez-Guzmán, M; Jiménez, R; Pérez-Vizcaíno, F; Quintela, AM; Romero, M; Sánchez, M; Tamargo, J; Zarzuelo, A; Zarzuelo, MJ, 2013) |
| "These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension." | 3.78 | Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. ( Kumar, S; Prahalathan, P; Raja, B, 2012) |
| " Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium." | 3.63 | DESOXYCORTICOSTERONE ACETATE : THE POTENTIATION OF ITS ACTIVITY BY SODIUM CHLORIDE. ( Knowlton, AI; Loeb, EN; Seegal, BC; Stoerk, HC, 1947) |
| "Although essential hypertension affects a large proportion of the human population and is one of the key drivers of cardiovascular mortality worldwide, we still do not have a complete understanding of its pathophysiology." | 2.72 | Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension. ( Wenzel, P; Wild, J, 2021) |
| "Animal models of hypertension have ranged from Goldblatt's kidney clip models in which the origin of the disease is clearly renal to animals that spontaneously develop hypertension either through targeted genetic manipulations, such as the TGR(mRen2)27, or selective breeding resulting in more enigmatic origins, as exemplified by the spontaneously hypertensive rat (SHR)." | 2.55 | DOCA-Salt Hypertension: an Update. ( Basting, T; Lazartigues, E, 2017) |
| "Calcitriol treatment attenuated FGF23-induced cardiac fibrosis and improved diastolic function via inhibition of transforming growth factor-β signaling." | 1.91 | Fibroblast Growth Factor 23 Exacerbates Cardiac Fibrosis in Deoxycorticosterone Acetate-Salt Mice With Hypertension. ( Honda, H; Kato, T; Koiwa, F; Mizobuchi, M; Ogata, H; Saito, T, 2023) |
| "Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation." | 1.91 | Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice. ( Broughton, BRS; de Veer, M; Li, Y; Ricardo, SD; Salimova, E; Samuel, CS; Zheng, G, 2023) |
| "Hypertension is a major global health problem." | 1.72 | Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats. ( Gadallah, M; Khodir, SA; Shabaan, A; Sweed, E, 2022) |
| "Hypertension was induced in swine by subcutaneous implantation of deoxycorticosterone acetate pellets in combination with a high-salt diet." | 1.62 | Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model. ( Cai, J; Cai, X; Chen, T; Chen, X; Chi, R; Fei, Y; Han, Y; Jiang, M; Li, K; Li, YG; Liu, M; Liu, Y; Qian, L; Shen, Y; Wang, D; Wang, W; Wei, Z; Yang, Y; Yu, S, 2021) |
| "Hypertension was induced in male C57BL6/J (WT) and IL-18−/− mice by uninephrectomy, deoxycorticosterone acetate (2." | 1.62 | IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice. ( Arumugam, TV; Diep, H; Drummond, GR; Ferens, DM; Guzik, TJ; Hickey, MJ; Huuskes, B; Jelinic, M; Kemp-Harper, BK; Krishnan, SM; Latz, E; Ling, YH; Mansell, A; O'Connor, PM; Saini, N; Sharma, P; Sobey, CG; Thomas, JM; Vinh, A, 2021) |
| "Hypertension is a multifaceted condition influenced by genetic and environmental factors and estimated to cause 9." | 1.62 | DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis. ( Collister, JP; Hartson, R; Johnson, TJ; Nahey, DB; Pestana-Oliveira, N; Weber, B, 2021) |
| "Chlorisondamine (CSD) has been used to assess the neurogenic contribution to blood pressure (BP) and vasomotor sympathetic tone in animal models." | 1.62 | Use of chlorisondamine to assess the neurogenic contribution to blood pressure in mice: An evaluation of method. ( Cooper, SG; Feng Earley, Y; Souza, LA; Thakore, P; Worker, CJ, 2021) |
| " Interestingly, the chronic administration of a combination of firibastat with [Enalapril+HCTZ] reduced plasma arginine-vasopressin levels by 62% relative to those measured in DOCA-salt rats receiving bitherapy." | 1.62 | Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats. ( Balavoine, F; De Mota, N; Hmazzou, R; Llorens-Cortes, C; Marc, Y, 2021) |
| "Hypertension is a leading risk factor for cerebrovascular disease and loss of brain health." | 1.62 | Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. ( De Silva, TM; Faraci, FM; Grobe, JL; Modrick, ML, 2021) |
| "Hypertension is the most common risk factor for cardiovascular disease, causing over 18 million deaths a year." | 1.56 | Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males. ( Abdelbary, M; Baban, B; Belanger, KM; Brands, MW; Crislip, GR; Elmarakby, A; Gillis, EE; Mohamed, R; Musall, JB; Sullivan, JC, 2020) |
| "Hypertension was induced by DOCA-salt administration for twelve weeks after the unilateral nephrectomy." | 1.56 | Reversal of deleterious effect of hypertension on the liver by inhibition of endoplasmic reticulum stress. ( Bal, NB; Demirel-Yilmaz, E; Han, S; Kiremitci, S; Uludag, MO, 2020) |
| "Intraocular pressure was found to be decreased by 36." | 1.56 | Repurposing of Iloperidone: Antihypertensive and ocular hypotensive activity in animals. ( Joshi, SV; Kalyankar, GG; Lodha, SR; Patel, EP; Vyas, BA, 2020) |
| "Hypertension was induced by deoxycorticosterone acetate (DOCA)-salt administration in uninephrectomized rats for 6 weeks." | 1.51 | Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes. ( Bal, NB; Demirel-Yilmaz, E; Han, S; Kiremitci, S; Sadi, G; Uludag, O; Usanmaz, SE, 2019) |
| "Hypertension was induced by deoxycorticosterone-acetate (DOCA) and salt administration in uni-nephrectomized rats for 12 weeks." | 1.51 | Hypertension-induced cardiac impairment is reversed by the inhibition of endoplasmic reticulum stress. ( Bal, NB; Demirel-Yilmaz, E; Han, S; Kiremitci, S; Sadi, G; Uludag, O, 2019) |
| "Hypertension is a civilization disease leading to remodeling and damage of blood vessels, impaired renal function and premature death." | 1.51 | Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor. ( Dobrzyńska, I; Figaszewski, ZA; Skrzydlewska, E; Szachowicz-Petelska, B; Weresa, J, 2019) |
| "DOCA-salt hypertension was induced by DOCA (20 mg/kg s." | 1.51 | Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist. ( Filipek, B; Kotańska, M; Kubacka, M; Marona, H; Mogilski, S; Nowak, B; Waszkielewicz, AM; Zadrożna, M, 2019) |
| "Obesity and hypertension are prevalent comorbidities in heart failure with preserved ejection fraction." | 1.51 | Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction. ( Brandt, MM; Cheng, C; Cramer, MJ; Duncker, DJ; Joles, JA; Krebber, MM; Mokry, M; Nguyen, ITN; van de Wouw, J; Verhaar, MC, 2019) |
| "Aldosterone is a key factor in adverse cardiovascular remodeling by acting on the mineralocorticoid receptor (MR) in different cell types." | 1.51 | Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis. ( Bode, C; Deng, L; Esser, JS; Fürst, D; Hein, L; Huck, M; Kowalski, J; Lother, A; Moser, M, 2019) |
| "Hypertension is associated with major cardiovascular (CV) and renal complications." | 1.51 | Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection. ( Amara, VR; Surapaneni, SK; Tikoo, K, 2019) |
| "Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated." | 1.51 | Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction. ( Bal, NB; Demirel-Yilmaz, E; Han, S; Sadi, G; Tuglu, MM; Uludag, MO; Usanmaz, SE, 2019) |
| "Hypertension was induced through unilateral nephrectomy and deoxycorticosterone-acetate (DOCA) injection (20 mg/kg, twice a week) for 6 weeks in male Wistar albino rats (8 weeks old)." | 1.48 | The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta. ( Bal, NB; Demirel-Yilmaz, E; Han, S; Sadi, G; Uludag, MO; Usanmaz, SE, 2018) |
| "Hypertension affected cardiac and plasma endocannabinoid systems in a model-dependent manner: anandamide and 2-arachidonoylglycerol levels decreased in SHR and increased in DOCA-salt." | 1.48 | Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. ( Biernacki, M; Jastrząb, A; Malinowska, B; Remiszewski, P; Skrzydlewska, E; Timoszuk, M; Toczek, M, 2018) |
| " This study investigated the effect of 28 days of low epicatechin dosing (1 mg/kg/day) on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats." | 1.48 | (-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats. ( Batacan, R; Connolly, K; Fenning, A; Jackson, D; Ryan, K; Vella, R, 2018) |
| "Hypertension is a metabolic disease which is caused by vasoconstriction and that results into elevated blood pressure." | 1.48 | Role of Acetyl Salicylic Acid in Controlling the DOCA-Salt Induced Hypertension in Rats by Stimulating the Synthesis of r-Cortexin in the Kidney. ( Chatterjee, M; Ghosh, TK; Jana, P; Karmakar, S; Maji, UK; Saha, A, 2018) |
| "Protocatechuic acid (PCA) is a natural antioxidant with beneficial cardiovascular properties." | 1.48 | Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats. ( Emami, R; Haghighatian, Z; Hajhashemi, V; Safaeian, L, 2018) |
| "Hypertension was promoted by subcutaneous injection of deoxycorticosterone acetate (DOCA, 25 mg/kg body weight/day, twice a week) and substitution of drinking water with 1." | 1.46 | Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products. ( Cheng, MC; Pan, TM, 2017) |
| " The aim of our study was to examine the age-specific influence of the chronic administration of the FAAH inhibitor URB597 on blood pressure (BP), heart rate (HR) and cardiac and renal hypertrophy in hypertensive rats during two critical periods for the development of hypertension." | 1.43 | Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats. ( Baranowska-Kuczko, M; Grzęda, E; Malinowska, B; Pędzińska-Betiuk, A; Toczek, M; Weresa, J, 2016) |
| "Hypertension is accompanied by perturbations to the endocannabinoid and antioxidant systems." | 1.43 | Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. ( Bielawska, K; Biernacki, M; Gęgotek, A; Skrzydlewska, E; Toczek, M; Łuczaj, W, 2016) |
| "Equol-treated DHRs showed a significant decrease in both the swimming distance and time required to reach the escape platform (78." | 1.43 | Effects of equol on deoxycorticosterone acetate salt-induced hypertension and associated vascular dementia in rats. ( Liu, TH; Tsai, TY, 2016) |
| " Reduction in BP after chronic administration of the FAAH inhibitor URB597 in DOCA-salt hypertensive rats only partially correlates with structural and functional changes in conductance and resistance vessels, respectively." | 1.43 | Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats. ( Baranowska-Kuczko, M; Harasim, E; Karpińska, O; Kasacka, I; Kloza, M; Kozłowska, H; Malinowska, B; Toczek, M, 2016) |
| "Hypertension was induced by using the deoxycorticosterone acetate (DOCA)-induced (15 mg/kg twice per week, subcutaneously) salt-sensitive hypertension model of Wistar rats." | 1.42 | Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension. ( Akcali, KC; Ayaloglu-Butun, F; Demirel-Yilmaz, E; Han, S; Uludag, MO; Usanmaz, SE, 2015) |
| "Because hypertension is characterized by arterial remodeling, we hypothesized that TG activity, expression, and functionality would be increased in the aorta, but not in the vena cava (which does not undergo remodeling), from hypertensive rats relative to normotensive rats." | 1.42 | Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls. ( Hitomi, K; Johnson, KB; Petersen-Jones, HG; Thompson, JM; Tykocki, NR; Watts, SW, 2015) |
| "Hypertension was induced by injection of DOCA-salt (25 mg/kg, s." | 1.42 | Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats. ( Akcilar, R; Ayada, C; Turgut, G; Turgut, S, 2015) |
| "This agent could be useful for the treatment of hypertension, cardiovascular and renal disorders." | 1.42 | Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist. ( Aoki, K; Arai, K; Homma, T; Ishikawa, H; Mizuno, M; Morikawa, Y; Sada, T; Tsuruoka, H; Ubukata, N, 2015) |
| "We induced hypertension and hyperlipidemia in landrace pigs (n = 8) by deoxycorticosteroneacetate (DOCA, 100 mg/kg, 90-day-release subcutaneous depot) and a Western diet (WD) containing high amounts of salt, fat, cholesterol, and sugar for 12 wk." | 1.42 | A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction. ( Alogna, A; Casadei, B; Eller, K; Eller, P; Hamdani, N; Höfler, G; Kirsch, A; Linke, WA; Maechler, H; Manninger, M; Pieske, BM; Post, H; Reilly, S; Schauer, S; Schwarzl, M; Seiler, S; Steendijk, P; Verderber, J; Zirngast, B; Zweiker, D, 2015) |
| " In order to identify pharmacokinetic changes (mainly non-renal clearance, CLNR) in 16-week-old SHRs due to hereditary characteristics and/or neither the hypertensive state itself, we reviewed the pharmacokinetics of drugs in 6- (blood pressure within a normotensive range) and 16-week-old SHRs and 16-week-old DOCA-salt rats compared with respective control rats." | 1.40 | Pharmacokinetics of drugs in spontaneously or secondary hypertensive rats. ( Lee, YS; Oh, E; Yang, S, 2014) |
| "Spironolactone treatment prevented Th17 cell activation and increased numbers of forkhead box P3-positive cells relative to DOCA-salt rats." | 1.40 | Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes. ( Alzamora, R; Amador, CA; Barrientos, V; Carrasco, L; Figueroa, F; González, M; Herrada, AA; Kalergis, AM; Michea, L; Peña, J; Valdés, S, 2014) |
| "Hypertension was induced in surgically single-kidney-removed (left) adult male albino Wistar rats, weighing 180-200 g, by injecting DOCA (25 mg/kg BW) subcutaneously twice a week for 6 weeks, with saline instead of tap water for drinking." | 1.39 | Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats. ( Hemalatha, G; Pugalendi, KV; Saravanan, R, 2013) |
| "Lacidipine-treated group (5) showed a significant reduction in elevated systolic blood pressure together with a great protection of ALT and SOD enzymes from the destructive effects of irradiation and hypertension." | 1.39 | Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. ( Kamal, SM, 2013) |
| "This sustained hypertension is not due to any anatomical fault in the kidney and in that sense is not primarily renal in origin." | 1.23 | Sustained hypertension following the administration of desoxycorticosterone acetate. ( FRIEDMAN, CL; FRIEDMAN, SM; NAKASHIMA, M, 1951) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (18.81) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 115 (52.75) | 24.3611 |
| 2020's | 62 (28.44) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, JM | 1 |
| Ling, YH | 2 |
| Huuskes, B | 1 |
| Jelinic, M | 1 |
| Sharma, P | 1 |
| Saini, N | 2 |
| Ferens, DM | 2 |
| Diep, H | 2 |
| Krishnan, SM | 2 |
| Kemp-Harper, BK | 2 |
| O'Connor, PM | 1 |
| Latz, E | 2 |
| Arumugam, TV | 1 |
| Guzik, TJ | 1 |
| Hickey, MJ | 1 |
| Mansell, A | 1 |
| Sobey, CG | 2 |
| Vinh, A | 2 |
| Drummond, GR | 2 |
| Robles-Vera, I | 2 |
| de la Visitación, N | 2 |
| Toral, M | 2 |
| Sánchez, M | 3 |
| Romero, M | 3 |
| Gómez-Guzmán, M | 3 |
| Vargas, F | 1 |
| Duarte, J | 3 |
| Jiménez, R | 3 |
| Temiz-Resitoglu, M | 1 |
| Guden, DS | 1 |
| Senol, SP | 1 |
| Vezir, O | 1 |
| Sucu, N | 1 |
| Kibar, D | 1 |
| Yılmaz, SN | 1 |
| Tunctan, B | 1 |
| Malik, KU | 1 |
| Sahan-Firat, S | 1 |
| Toba, H | 3 |
| Ikemoto, MJ | 1 |
| Kobara, M | 2 |
| Nakata, T | 3 |
| Zhang, L | 2 |
| Yang, Y | 2 |
| Aroor, AR | 1 |
| Jia, G | 1 |
| Sun, Z | 1 |
| Parrish, A | 1 |
| Litherland, G | 1 |
| Bonnard, B | 1 |
| Jaisser, F | 1 |
| Sowers, JR | 1 |
| Hill, MA | 1 |
| Bal, NB | 6 |
| Bostanci, A | 1 |
| Sadi, G | 5 |
| Dönmez, MO | 1 |
| Uludag, MO | 5 |
| Demirel-Yilmaz, E | 7 |
| Khodir, SA | 1 |
| Sweed, E | 1 |
| Gadallah, M | 1 |
| Shabaan, A | 1 |
| Patil, CN | 1 |
| Ritter, ML | 1 |
| Wackman, KK | 3 |
| Oliveira, V | 1 |
| Balapattabi, K | 1 |
| Grobe, CC | 3 |
| Brozoski, DT | 3 |
| Reho, JJ | 3 |
| Nakagawa, P | 3 |
| Mouradian, GC | 2 |
| Kriegel, AJ | 1 |
| Kwitek, AE | 1 |
| Hodges, MR | 2 |
| Segar, JL | 3 |
| Sigmund, CD | 7 |
| Grobe, JL | 6 |
| Thowsen, IM | 2 |
| Karlsen, TV | 2 |
| Nikpey, E | 2 |
| Haslene-Hox, H | 1 |
| Skogstrand, T | 3 |
| Randolph, GJ | 1 |
| Zinselmeyer, BH | 1 |
| Tenstad, O | 3 |
| Wiig, H | 3 |
| Benson, LN | 1 |
| Liu, Y | 6 |
| Wang, X | 4 |
| Xiong, Y | 1 |
| Rhee, SW | 1 |
| Guo, Y | 1 |
| Deck, KS | 1 |
| Mora, CJ | 1 |
| Li, LX | 1 |
| Huang, L | 1 |
| Andrews, JT | 1 |
| Qin, Z | 1 |
| Hoover, RS | 1 |
| Ko, B | 1 |
| Williams, RM | 1 |
| Heller, DA | 1 |
| Jaimes, EA | 1 |
| Mu, S | 1 |
| Luettges, K | 1 |
| Bode, M | 1 |
| Diemer, JN | 1 |
| Schwanbeck, J | 1 |
| Wirth, EK | 1 |
| Klopfleisch, R | 1 |
| Kappert, K | 1 |
| Thiele, A | 1 |
| Ritter, D | 1 |
| Foryst-Ludwig, A | 1 |
| Kolkhof, P | 1 |
| Wenzel, UO | 2 |
| Kintscher, U | 1 |
| Guy, R | 1 |
| Volkman, R | 1 |
| Wilczynski, E | 1 |
| Yagil, C | 1 |
| Yagil, Y | 1 |
| Findler, M | 1 |
| Auriel, E | 1 |
| Nevo, U | 1 |
| Offen, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Innovative Natural Dietary Formulation on Primary Hypertension and the Underlying Mechanism of Gut Microbiome Restoration: Pilot Study[NCT04403347] | Early Phase 1 | 90 participants (Anticipated) | Interventional | 2021-07-08 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for desoxycorticosterone acetate and Hypertension
| Article | Year |
|---|---|
Myeloid cells, tissue homeostasis, and anatomical barriers as innate immune effectors in arterial hypertension.
Topics: Angiotensin II; Animals; Antimicrobial Cationic Peptides; Complement Activation; Desoxycorticosteron | 2021 |
DOCA-Salt Hypertension: an Update.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Humans; Hypertension; Kidney; Sodium Chloride | 2017 |
216 other studies available for desoxycorticosterone acetate and Hypertension
| Article | Year |
|---|---|
IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.
Topics: Albuminuria; Animals; Blood Pressure; Desoxycorticosterone Acetate; Epithelial Cells; Hypertension; | 2021 |
Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats.
Topics: Animals; Anti-Bacterial Agents; Desoxycorticosterone Acetate; Disease Models, Animal; Doxycycline; E | 2021 |
Pharmacological Inhibition of Mammalian Target of Rapamycin Attenuates Deoxycorticosterone Acetate Salt-Induced Hypertension and Related Pathophysiology: Regulation of Oxidative Stress, Inflammation, and Cardiovascular Hypertrophy in Male Rats.
Topics: Acetates; Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Hypertrophy; Inflamma | 2022 |
Secreted protein acidic and rich in cysteine (SPARC) and a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) increments by the renin-angiotensin system induce renal fibrosis in deoxycorticosterone acetate-salt hypertensive rats.
Topics: ADAMTS1 Protein; Angiotensin II Type 1 Receptor Blockers; Animals; Desoxycorticosterone Acetate; Ext | 2022 |
Endothelial sodium channel activation mediates DOCA-salt-induced endothelial cell and arterial stiffening.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Endothelial Cells; Epithelial Sodium Channels | 2022 |
Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses.
Topics: Animals; Desoxycorticosterone Acetate; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Ex | 2022 |
Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats.
Topics: Acetates; Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Lipids; Male; Rats; R | 2022 |
Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.
Topics: Animals; Aquaporin 2; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Diet; Hype | 2022 |
Na
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Electrolytes; Glycosami | 2022 |
The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension.
Topics: Animals; CD8-Positive T-Lymphocytes; Desoxycorticosterone Acetate; Disease Models, Animal; Hypertens | 2022 |
Finerenone Reduces Renal RORγt γδ T Cells and Protects against Cardiorenal Damage.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Hypertension, Renal; | 2022 |
A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress.
Topics: Animals; Cerebral Hemorrhage; Cerebral Small Vessel Diseases; Desoxycorticosterone Acetate; Hyperten | 2022 |
Elucidation of Anti-Hypertensive Mechanism by a Novel
Topics: Acetates; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Desoxycorticostero | 2022 |
Genetic Engineering of Lymphangiogenesis in Skin Does Not Affect Blood Pressure in Mouse Models of Salt-Sensitive Hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Disease Models, Animal; | 2022 |
Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension.
Topics: Angiotensin II; Animals; Cholinergic Agents; Desoxycorticosterone Acetate; Hypertension; Mice; NADPH | 2022 |
Captopril Alleviates Chondrocyte Senescence in DOCA-Salt Hypertensive Rats Associated with Gut Microbiome Alteration.
Topics: Acetates; Animals; Antihypertensive Agents; Captopril; Chondrocytes; Desoxycorticosterone Acetate; D | 2022 |
Effects of intrarenal angiotensin 1-7 infusion on renal haemodynamic and excretory function in anaesthetised two-kidney one-clip and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetates; Angiotensin II; Animals; Desoxycorticosterone Acetate; Hemodynamics; Hypertension; Kidney; | 2023 |
Effects of intrarenal angiotensin 1-7 infusion on renal haemodynamic and excretory function in anaesthetised two-kidney one-clip and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetates; Angiotensin II; Animals; Desoxycorticosterone Acetate; Hemodynamics; Hypertension; Kidney; | 2023 |
Effects of intrarenal angiotensin 1-7 infusion on renal haemodynamic and excretory function in anaesthetised two-kidney one-clip and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetates; Angiotensin II; Animals; Desoxycorticosterone Acetate; Hemodynamics; Hypertension; Kidney; | 2023 |
Effects of intrarenal angiotensin 1-7 infusion on renal haemodynamic and excretory function in anaesthetised two-kidney one-clip and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetates; Angiotensin II; Animals; Desoxycorticosterone Acetate; Hemodynamics; Hypertension; Kidney; | 2023 |
Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice.
Topics: Animals; Contrast Media; Desoxycorticosterone Acetate; Fibrosis; Gadolinium; Humans; Hypertension; M | 2023 |
Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice.
Topics: Animals; Contrast Media; Desoxycorticosterone Acetate; Fibrosis; Gadolinium; Humans; Hypertension; M | 2023 |
Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice.
Topics: Animals; Contrast Media; Desoxycorticosterone Acetate; Fibrosis; Gadolinium; Humans; Hypertension; M | 2023 |
Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice.
Topics: Animals; Contrast Media; Desoxycorticosterone Acetate; Fibrosis; Gadolinium; Humans; Hypertension; M | 2023 |
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Topics: Animals; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Hypertension, Renal; Kidney; Mice; Tr | 2023 |
The DOCA-Salt Model of Hypertension for Studies of Cerebrovascular Function, Stroke, and Brain Health.
Topics: Acetates; Aldosterone; Brain; Desoxycorticosterone Acetate; Humans; Hypertension; Renin-Angiotensin | 2023 |
Fibroblast Growth Factor 23 Exacerbates Cardiac Fibrosis in Deoxycorticosterone Acetate-Salt Mice With Hypertension.
Topics: Animals; Blood Pressure; Calcitriol; Desoxycorticosterone Acetate; Fibroblast Growth Factor-23; Fibr | 2023 |
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
Topics: Acetates; Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Hyp | 2023 |
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.
Topics: Animals; Cardiomegaly; Desoxycorticosterone Acetate; Heart Failure; Heart Failure, Systolic; Hyperte | 2023 |
Renal Medullary Overexpression of Sphingosine-1-Phosphate Receptor 1 Transgene Attenuates Deoxycorticosterone Acetate (DOCA)-Salt Hypertension.
Topics: Acetates; Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Kidney; Male; Mice; M | 2023 |
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Hypertension; | 2023 |
P2Y2 receptor decreases blood pressure by inhibiting ENaC.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Mice; Mice, Knockout; Receptors | 2023 |
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone Acetate; Heart Failure; Humans; Hypertension; Leukoc | 2023 |
Role of Brain Endothelin Receptor Type B (ET
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Endothelin-1; Endothelins; Hypertension; Olfa | 2023 |
Small artery remodeling and stiffening in deoxycorticosterone acetate-salt hypertensive rats involves the interaction between endogenous ouabain/Na + K + -ATPase/cSrc signaling.
Topics: Acetates; Adenosine Triphosphatases; Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticoste | 2023 |
Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Humans; Hypertension; M | 2023 |
Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Female; Hypertension; Mice; Prorenin Receptor | 2023 |
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension: Erratum.
Topics: Acetates; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Fibrosis; Humans; Hype | 2023 |
Activation of Liver X Receptors by GW3965 Attenuated Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Functional and Structural Changes.
Topics: Animals; Apoptosis; Benzoates; Benzylamines; Blood Pressure; Desoxycorticosterone Acetate; Disease M | 2019 |
Role of endothelin receptor type A on catecholamine regulation in the olfactory bulb of DOCA-salt hypertensive rats: Hemodynamic implications.
Topics: Animals; Blood Pressure; Catecholamines; Desoxycorticosterone Acetate; Hemodynamics; Hypertension; M | 2019 |
Antihypertensive and Renoprotective Effects of Dietary Flaxseed and its Mechanism of Action in Deoxycorticosterone Acetate-Salt Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Cytokines; Desoxycorticosterone Acetate; Dietary Fiber; Flax; Gene | 2020 |
Hypertension-induced cardiac impairment is reversed by the inhibition of endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Blood Pressure; Calcium; Desoxycorticosterone Acetate; Disease Models, Animal; E | 2019 |
DOCA/Salt: Much More Than a Model of Hypertension.
Topics: Blood Pressure; Desoxycorticosterone Acetate; Humans; Hypertension | 2019 |
Genetic ablation and pharmacological inhibition of immunosubunit β5i attenuates cardiac remodeling in deoxycorticosterone-acetate (DOCA)-salt hypertensive mice.
Topics: Animals; Cardiomegaly; Chymotrypsin; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Inflammat | 2019 |
Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension.
Topics: Animals; Calcinosis; Calcium; Cardiovascular System; Desoxycorticosterone Acetate; Fibrosis; Hyperte | 2019 |
CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p.
Topics: Aldehyde Oxidoreductases; Animals; Base Sequence; Desoxycorticosterone Acetate; Gene Expression Regu | 2020 |
Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities.
Topics: Aged; Animals; Antihypertensive Agents; Blood Pressure; Cannabidiol; Desoxycorticosterone Acetate; E | 2020 |
Repurposing of Iloperidone: Antihypertensive and ocular hypotensive activity in animals.
Topics: Animals; Antihypertensive Agents; Antipsychotic Agents; Blood Pressure; Desoxycorticosterone Acetate | 2020 |
Grape Extract from Chardonnay Seeds Restores Deoxycorticosterone Acetate-Salt-Induced Endothelial Dysfunction and Hypertension in Rats.
Topics: Animals; Aorta, Thoracic; Cell Line; Desoxycorticosterone Acetate; Endothelial Cells; Endothelium, V | 2020 |
Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Extracellular Matrix Proteins; Fibroblasts; F | 2020 |
Reversal of deleterious effect of hypertension on the liver by inhibition of endoplasmic reticulum stress.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Endoplasmic Reticulum | 2020 |
Preventive Beneficial Effect of an Aqueous Extract of Phyllanthus amarus Schum. and Thonn. (Euphorbiaceae) on DOCA-Salt-Induced Hypertension, Cardiac Hypertrophy and Dysfunction, and Endothelial Dysfunction in Rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Desoxycorticosterone Acetate; Di | 2020 |
Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency.
Topics: Albuminuria; Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Female; | 2020 |
Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males.
Topics: Animals; Blood Pressure; Cardiometabolic Risk Factors; Cell Count; Desoxycorticosterone Acetate; Fem | 2020 |
Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice.
Topics: Actins; Albuminuria; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blotting, Wes | 2020 |
Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice.
Topics: Angiotensin II; Animals; Antibody Affinity; Aorta; Blood Pressure; Cells, Cultured; Cytidine Deamina | 2021 |
Probiotic Bifidobacterium breve prevents DOCA-salt hypertension.
Topics: Animals; Bifidobacterium breve; Blood Pressure; Desoxycorticosterone Acetate; Gastrointestinal Micro | 2020 |
COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Cyclooxygenase 2; Desoxycorticosterone Acetate; Disease Model | 2020 |
Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury.
Topics: Animals; Arterioles; Blood Pressure; Calmodulin-Binding Proteins; Desoxycorticosterone Acetate; Dise | 2020 |
Sodium butyrate ameliorates deoxycorticosterone acetate/salt-induced hypertension and renal damage by inhibiting the MR/SGK1 pathway.
Topics: Acetates; Animals; Blood Pressure; Butyric Acid; Desoxycorticosterone Acetate; Hypertension; Immedia | 2021 |
Oestrogen inhibits salt-dependent hypertension by suppressing GABAergic excitation in magnocellular AVP neurons.
Topics: Animals; Antihypertensive Agents; Arginine Vasopressin; Basal Nucleus of Meynert; Blood Pressure; De | 2021 |
Triptolide attenuates renal damage by limiting inflammatory responses in DOCA-salt hypertension.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion Molecules; Cytokines; Desoxycorticosterone Acetate; | 2020 |
Dietary supplementation of Huangshan Maofeng green tea preventing hypertension of older C57BL/6 mice induced by desoxycorticosterone acetate and salt.
Topics: Animals; Aorta; Blood Pressure; Desoxycorticosterone Acetate; Dietary Supplements; Humans; Hypertens | 2021 |
No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension.
Topics: Angiotensin II; Angiotensinogen; Animals; Brain; Brain Stem; Desoxycorticosterone Acetate; Hypertens | 2021 |
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Hypertens | 2021 |
DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Gastrointestinal Microbiome; Hypertension; Or | 2021 |
Collecting duct-specific knockout of sphingosine-1-phosphate receptor 1 aggravates DOCA-salt hypertension in mice.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Kidney; M | 2021 |
Use of chlorisondamine to assess the neurogenic contribution to blood pressure in mice: An evaluation of method.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Chlorisondamine; Desoxycorticosteron | 2021 |
Further evidence against the role renal medullary perfusion in short-term control of arterial pressure in normotensive and mildly or overtly hypertensive rats.
Topics: Animals; Arterial Pressure; Bradykinin; Desoxycorticosterone Acetate; Hypertension; Kidney Medulla; | 2021 |
Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension.
Topics: Angiotensin III; Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Brain; Desoxycor | 2021 |
Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Desoxycorticosterone Acetate; Dis | 2021 |
Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction.
Topics: Animals; Cerebrovascular Disorders; Desoxycorticosterone Acetate; Endothelium, Vascular; Female; Hyp | 2021 |
Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Female; Hypertension; | 2021 |
Brain Renin-Angiotensin System: Does It Exist?
Topics: Amides; Angiotensin II; Angiotensinogen; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Desoxy | 2017 |
Knockout of immunoproteasome subunit β2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice.
Topics: Animals; Cysteine Endopeptidases; Desoxycorticosterone Acetate; Fibrosis; Hypertension; Inflammation | 2017 |
The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Chromatography, Gas; Chromatograph | 2017 |
Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats.
Topics: Animals; Biomarkers; Blood Pressure; Desoxycorticosterone Acetate; Electrocardiography; Heart; Heart | 2017 |
Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
Topics: Animals; Aorta; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone Acetat | 2017 |
Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Brain; | 2018 |
Role of Acetyl Salicylic Acid in Controlling the DOCA-Salt Induced Hypertension in Rats by Stimulating the Synthesis of r-Cortexin in the Kidney.
Topics: Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Desoxycorticosterone Acetate; Dose-Respon | 2018 |
Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Ganglia, Sympathetic; | 2018 |
Macrophage-dependent impairment of α
Topics: Adrenergic Fibers; Animals; Arterial Pressure; Calcium Channels, N-Type; Calcium Signaling; Desoxyco | 2018 |
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
Topics: Animals; Blood Pressure; Circadian Rhythm; Desoxycorticosterone Acetate; Disease Models, Animal; Epi | 2018 |
RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice.
Topics: Acetates; Acute Kidney Injury; Aldosterone; Animals; Aptamers, Peptide; Blood Pressure; Desoxycortic | 2018 |
Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Desoxycorticosterone Acetate; Diseas | 2018 |
The nerve of the spleen! Causing hypertension by placental growth factor.
Topics: Acetates; Desoxycorticosterone Acetate; Female; Humans; Hypertension; Pregnancy; Spleen | 2018 |
Chronic Blockade of Brain Endothelin Receptor Type-A (ET
Topics: Animals; Blood Pressure; Catecholamines; Desoxycorticosterone Acetate; Disease Models, Animal; Endot | 2018 |
Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat.
Topics: Animals; Arterial Pressure; Circadian Rhythm; Denervation; Desoxycorticosterone Acetate; Hypertensio | 2018 |
The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension.
Topics: Animals; Benzamides; Blood Glucose; Carbamates; Desoxycorticosterone Acetate; Glucose; Glucose Trans | 2018 |
Lesion of the OVLT markedly attenuates chronic DOCA-salt hypertension in rats.
Topics: Animals; Arterial Pressure; Blood Pressure Monitoring, Ambulatory; Desoxycorticosterone Acetate; Dis | 2018 |
(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats.
Topics: Action Potentials; Animals; Antihypertensive Agents; Blood Pressure; Catechin; Desoxycorticosterone | 2018 |
Neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Food Preferences; Hypertension; Mice, Inbred | 2018 |
Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Desoxycorticosterone Acetate; E | 2018 |
The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Desoxycorticosterone Acetate; Disease Models, Anim | 2018 |
Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Desoxycorticosterone Acetate; Hemodynam | 2019 |
TRPV4 activation in rat carotid artery in DOCA hypertension involves eNOS and endothelium-derived contractile factor (EDCF).
Topics: Animals; Blood Pressure; Carotid Artery, Common; Desoxycorticosterone Acetate; Disease Models, Anima | 2019 |
Multiple Sclerosis Drug Fingolimod Induces Thrombotic Microangiopathy in Deoxycorticosterone Acetate/Salt Hypertension.
Topics: Animals; Arterioles; Blood Pressure; Desoxycorticosterone Acetate; Endothelium, Vascular; Fingolimod | 2018 |
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Topics: Albuminuria; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Chemotaxis, | 2019 |
The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta.
Topics: Animals; Aorta; Benzoates; Benzylamines; Blood Pressure; Cardiovascular Diseases; Desoxycorticostero | 2018 |
Endothelial cell mineralocorticoid receptors oppose VEGF-induced gene expression and angiogenesis.
Topics: Aldosterone; Animals; Aorta; Cells, Cultured; Desoxycorticosterone Acetate; Disease Models, Animal; | 2019 |
Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Apoptosis; Blood Pressure; Calcium; Cell Prolifer | 2019 |
Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Membrane; Chromatography, High Pressure Liqui | 2019 |
IGF-1 deletion affects renal sympathetic nerve activity, left ventricular dysfunction, and renal function in DOCA-salt hypertensive mice.
Topics: Animals; Desoxycorticosterone Acetate; Hypertension; Insulin-Like Growth Factor I; Kidney; Male; Mic | 2019 |
Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats.
Topics: Actins; Albumins; Animals; Apoptosis; Biomarkers; Creatinine; Desoxycorticosterone Acetate; Disease | 2019 |
Reversal of cardiac, vascular, and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: a comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; | 2019 |
Renal Inflammation in DOCA-Salt Hypertension.
Topics: Animals; Blood Pressure; Cytokines; Desoxycorticosterone Acetate; Disease Models, Animal; Hypertensi | 2019 |
Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model.
Topics: Animals; Antigens, CD; Blood Pressure; Brain; Calcium-Binding Proteins; Carboxymethylcellulose Sodiu | 2019 |
Exacerbated effects of prorenin on hypothalamic magnocellular neuronal activity and vasopressin plasma levels during salt-sensitive hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; Hypertension; Hypotha | 2019 |
Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction.
Topics: Animals; Apoptosis; Capillaries; Desoxycorticosterone Acetate; Disease Progression; Fatty Acids; Fib | 2019 |
Cerebral aqueduct block attenuates cardio-renal injuries in post-DOCA-NaCl-hypertensive Dahl R rats.
Topics: Animals; Cerebral Aqueduct; Desoxycorticosterone Acetate; Heart Diseases; Hypertension; Kidney Disea | 2013 |
Etoricoxib attenuates effect of antihypertensives in a rodent model of DOCA-salt induced hypertension.
Topics: Animals; Antihypertensive Agents; Atenolol; Benzimidazoles; Benzoates; Blood Pressure; Cyclooxygenas | 2013 |
Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone Acetate | 2012 |
Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats.
Topics: Animals; Antihypertensive Agents; Ascorbic Acid; Benzodioxoles; Blood Pressure; Catalase; Desoxycort | 2013 |
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.
Topics: Actin Depolymerizing Factors; Acute Kidney Injury; Albuminuria; Animals; cdc42 GTP-Binding Protein; | 2013 |
Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Endothelin-1; Endothelium, Vascular; Hyperten | 2013 |
Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension.
Topics: Animals; Basilar Artery; Blood Pressure; Body Weight; Chloride Channels; Desoxycorticosterone Acetat | 2013 |
Pharmacokinetics of drugs in spontaneously or secondary hypertensive rats.
Topics: Age Factors; Animals; Cytochrome P-450 Enzyme System; Desoxycorticosterone Acetate; Disease Models, | 2014 |
HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity.
Topics: Animals; Cardiomegaly; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Activation; Fibr | 2013 |
Enhanced assymetrical noradrenergic transmission in the olfactory bulb of deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Desoxycorticosterone Acetate; Functional Laterality; Hypertension; Male; Norepinephrine; Ol | 2013 |
α-MSH analogue attenuates blood pressure elevation in DOCA-salt hypertensive mice.
Topics: alpha-MSH; Animals; Biomarkers; Blood Pressure; Cyclic GMP; Desoxycorticosterone Acetate; Diuresis; | 2013 |
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin- | 2013 |
Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.
Topics: Animals; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; He | 2013 |
Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Desoxycorticostero | 2014 |
Deficiency of the interleukin 17/23 axis accelerates renal injury in mice with deoxycorticosterone acetate+angiotensin ii-induced hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Interleukin-17; | 2014 |
Roles of hypertension in the rupture of intracranial aneurysms.
Topics: Aneurysm, Ruptured; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Desoxycorticosteron | 2014 |
Synergistic effects of high blood cholesterol and hypertension on leukocyte and platelet recruitment in the cerebral microcirculation.
Topics: Animals; Apolipoproteins E; Blood Platelets; Cell Adhesion; Cell Movement; Cerebrovascular Circulati | 2014 |
Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes.
Topics: Animals; Antibodies; Desoxycorticosterone Acetate; Disease Models, Animal; Down-Regulation; Forkhead | 2014 |
Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Desoxycorticosterone Acetate; Endothelin Receptor Antagonists; | 2014 |
Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats.
Topics: Alanine Transaminase; Animals; Blood Pressure; Desoxycorticosterone Acetate; Dihydropyridines; Disea | 2013 |
Characterization of musclin as a new target for treatment of hypertension.
Topics: Animals; Calcium; Desoxycorticosterone Acetate; Disease Models, Animal; Gene Expression Regulation; | 2014 |
Effect of DOCA/salt hypertension on CRF expression in the amygdala and the autonomic stress response in conscious rats.
Topics: Amygdala; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Consciousness; Corticotropi | 2014 |
Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.
Topics: Androgen Antagonists; Animals; Antihypertensive Agents; Chlorocebus aethiops; COS Cells; Crystallogr | 2014 |
Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Vessels; Desoxycorticosterone Ace | 2015 |
Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism.
Topics: Animals; Cerebrovascular Circulation; Desoxycorticosterone Acetate; Enzyme Induction; Gene Expressio | 2015 |
[Effect of inhibiting brain reactive oxygen species on sympathetic nerve activity in DOCA-salt hypertensive rats].
Topics: Animals; Antioxidants; Arterial Pressure; Blood Pressure; Brain; Cyclic N-Oxides; Desoxycorticostero | 2014 |
Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Binding, Competitive; Blood Pressure; | 2015 |
Study of cerebral aneurysms in a modified rat model: from real-time imaging to histological analysis.
Topics: Animals; Cerebral Angiography; Cerebral Arteries; Computer Systems; Desoxycorticosterone Acetate; Hy | 2015 |
Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation.
Topics: Angiotensin-Converting Enzyme 2; Animals; Antioxidants; Brain; Cyclooxygenase 1; Cyclooxygenase 2; D | 2015 |
Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress.
Topics: Angiotensin-Converting Enzyme 2; Animals; Biomarkers; Blood Pressure; Brain; Desoxycorticosterone Ac | 2015 |
Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Bone Marrow Transplantation; Cell Communication; | 2015 |
Role of the monocyte chemoattractant protein-1/C-C chemokine receptor 2 signaling pathway in transient receptor potential vanilloid type 1 ablation-induced renal injury in salt-sensitive hypertension.
Topics: Animals; Benzoxazines; Body Weight; Chemokine CCL2; Desoxycorticosterone Acetate; Hypertension; Kidn | 2015 |
Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Desoxycorticosterone Acetate; Disease Models, Animal; Dow | 2015 |
Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats.
Topics: Animals; Apelin; Calcium-Binding Proteins; Desoxycorticosterone Acetate; Disease Models, Animal; DNA | 2015 |
Involvement of endothelins in deoxycorticosterone acetate-salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus.
Topics: Adrenergic Neurons; Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; E | 2015 |
Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats.
Topics: Analysis of Variance; Angiotensin II Type 2 Receptor Blockers; Animals; Blood Pressure; Brain; Cytok | 2015 |
Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt.
Topics: Analysis of Variance; Animals; Blood Pressure; Brain; Desoxycorticosterone Acetate; Disease Models, | 2015 |
Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats.
Topics: Animals; Benzamides; Blood Pressure; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists | 2015 |
Protective effects of grape seed proanthocyanidins on cardiovascular remodeling in DOCA-salt hypertension rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Desoxycorticosterone Acetate; Endothelin-1; Grape Se | 2015 |
Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2015 |
Grape seed proanthocyanidins prevent DOCA-salt hypertension-induced renal injury and its mechanisms in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone Acetate; Grape Seed Extract; | 2015 |
Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
Topics: Administration, Oral; Adrenalectomy; Aldosterone; Animals; Antihypertensive Agents; Binding, Competi | 2015 |
Beneficial effects of angiotensin-(1-7) against deoxycorticosterone acetate-induced diastolic dysfunction occur independently of changes in blood pressure.
Topics: Angiotensin I; Animals; Blood Pressure; Calcium; Calcium Signaling; Desoxycorticosterone Acetate; Di | 2015 |
Resveratrol via activation of AMPK lowers blood pressure in DOCA-salt hypertensive mice.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Blood Pressure; Desoxycorticosteron | 2015 |
Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Topics: Adrenergic alpha-2 Receptor Agonists; Aminopyridines; Animals; Antihypertensive Agents; Benzamides; | 2015 |
PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice.
Topics: Animals; Aorta; Blood Pressure; Cells, Cultured; Desoxycorticosterone Acetate; Disease Models, Anima | 2015 |
Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.
Topics: Animals; Blood Pressure; Clodronic Acid; Desoxycorticosterone Acetate; Hypertension; Macrophages; Ma | 2015 |
A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction.
Topics: Animals; Cardiomyopathies; Connectin; Desoxycorticosterone Acetate; Diet, Western; Dilatation, Patho | 2015 |
Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Aorta; Desoxycorticosterone Acetate; Disease Models, | 2016 |
Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure.
Topics: Animals; Blood Pressure; Cells, Cultured; Desoxycorticosterone Acetate; Disease Models, Animal; Endo | 2016 |
Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Disease Models, Animal; DNA; Gene Expression | 2016 |
Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCA/NaCl-Induced Hypertension in Female Rats.
Topics: Animals; Blood Pressure; Cytokines; Desoxycorticosterone Acetate; Female; Heart Rate; Hypertension; | 2016 |
Beta3 adrenergic receptor is involved in vascular injury in deoxycorticosterone acetate-salt hypertensive mice.
Topics: 3' Untranslated Regions; 3T3-L1 Cells; Adipose Tissue; Adrenergic beta-3 Receptor Antagonists; Anima | 2016 |
Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Blood Pressure; Carbamates; Desoxycorticosterone Acetate; Hear | 2016 |
Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats.
Topics: Animals; Congenital Abnormalities; Desoxycorticosterone Acetate; Disease Progression; Female; Hypert | 2016 |
Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats.
Topics: Amidohydrolases; Animals; Aorta; Arachidonic Acids; Benzamides; Blood Pressure; Capsaicin; Carbamate | 2016 |
Endothelial dysfunction in DOCA-salt-hypertensive mice: role of neuronal nitric oxide synthase-derived hydrogen peroxide.
Topics: Animals; Desoxycorticosterone Acetate; Disease Models, Animal; Endothelium, Vascular; Hydrogen Perox | 2016 |
Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Catalase; Desoxycorticosterone Acetate; Endocannab | 2016 |
Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice.
Topics: Animals; Aorta; Blood Pressure; Cell Adhesion Molecules; Desoxycorticosterone Acetate; Hypertension; | 2016 |
Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.
Topics: Adoptive Transfer; Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Blood Pressure; CD4-Positive T- | 2016 |
Protective effects of MCR-1329, a dual α1 and angII receptor antagonist, in mineralocorticoid-induced hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; | 2016 |
CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Gene Expression Regulation; Hypertension; Kid | 2016 |
Effects of equol on deoxycorticosterone acetate salt-induced hypertension and associated vascular dementia in rats.
Topics: Acetylcholinesterase; Animals; Blood Pressure; Body Weight; Brain; Catalase; Dementia, Vascular; Des | 2016 |
Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury.
Topics: Animals; Blood Pressure; Cells, Cultured; Desoxycorticosterone Acetate; Hypertension; Kidney; Kidney | 2016 |
DOCA-salt hypertension impairs artery function in rat middle cerebral artery and parenchymal arterioles.
Topics: Animals; Arterioles; Cerebral Arteries; Cyclooxygenase Inhibitors; Desoxycorticosterone Acetate; End | 2016 |
Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension.
Topics: Animals; Desoxycorticosterone Acetate; Disease Models, Animal; Hypertension; Kidney; Male; Nephritis | 2016 |
Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; India; | 2016 |
High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.
Topics: Animals; Bacteria; Blood Pressure; Desoxycorticosterone Acetate; Dietary Fiber; Dietary Supplements; | 2017 |
Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products.
Topics: Animals; Aorta; Behavior, Animal; Blood Pressure; Cultured Milk Products; Cytokines; Dementia; Desox | 2017 |
Cardiac structural remodeling in hypertensive cardiomyopathy.
Topics: Animals; Cardiomyopathies; Desoxycorticosterone Acetate; Diet, High-Fat; Echocardiography; Female; F | 2017 |
Immediate pressor effect of desoxycorticosterone acetate in arterial hypertension.
Topics: Blood Pressure; Blood Pressure Determination; Desoxycorticosterone; Desoxycorticosterone Acetate; Hy | 1948 |
Potentiation of the hypertensive effects of desoxycorticosterone acetate by various sodium salts.
Topics: Blood Pressure; Blood Pressure Determination; Desoxycorticosterone; Desoxycorticosterone Acetate; Hy | 1948 |
The effect of desoxycorticosterone acetate and propylene glycol in experimental renal hypertension.
Topics: Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; Hypertension; Hypertensi | 1948 |
Hypertension produced with desoxycorticosterone acetate and sodium chloride in a case of postural hypotension.
Topics: Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; Humans; Hypertension; Hy | 1948 |
Influence of diet upon the hypertension and nephrosclerosis produced by desoxycorticosterone acetate overdosage.
Topics: Adrenal Glands; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; Diet; Hy | 1947 |
The immediate pressor effect of desoxycorticosterone acetate in hypertensive and normotensive subjects.
Topics: Adrenal Glands; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; Humans; | 1948 |
DESOXYCORTICOSTERONE ACETATE : THE POTENTIATION OF ITS ACTIVITY BY SODIUM CHLORIDE.
Topics: Adrenal Glands; Animals; Cardiomegaly; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertens | 1947 |
Pressor activity of desoxycorticosterone acetate in normotensive and hypertensive subjects.
Topics: Adrenal Glands; Blood Pressure; Desoxycorticosterone Acetate; Humans; Hypertension; Tissue Extracts; | 1947 |
Apelin-induced hemorheological alterations in DOCA-salt hypertensive rats.
Topics: Animals; Apelin; Desoxycorticosterone Acetate; Disease Models, Animal; Erythrocyte Aggregation; Eryt | 2014 |
Apelin effects on blood pressure and RAS in DOCA-salt-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensinogen; Animals; Aorta; Apelin; Apelin Rec | 2013 |
Inhibition of cardiovascular-renal effects of DOCA by pitressin.
Topics: Arginine Vasopressin; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Kidney; Vaso | 1952 |
[Arterial hypertension during desoxycorticosterone acetate therapy of Addison's disease; clinical and statistical study].
Topics: Addison Disease; Adrenal Insufficiency; Desoxycorticosterone; Desoxycorticosterone Acetate; Hyperten | 1952 |
[Production of meta-corticoid hypertension by minimal doses of DOCA (desoxycorticosterone acetate)].
Topics: Adrenal Cortex Hormones; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension | 1953 |
The influence of 3-methylglucose on the hypertension and cardiovascular-renal changes elicited by desoxycorticosterone acetate in the rat.
Topics: Animals; Cardiovascular Diseases; Desoxycorticosterone; Desoxycorticosterone Acetate; Glucose; Hyper | 1954 |
Effect of thyroidectomy on hypertension, nephrosclerosis and cardiac lesions produced by desoxycorticosterone acetate (DCA) treatment in the rat.
Topics: Animals; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Myocardium; Nephroscleros | 1954 |
[Effect of ascorbic acid, of cortisone, and of adrenalectomy on experimental hypertension produced by DOCA].
Topics: Adrenal Glands; Adrenalectomy; Ascorbic Acid; Cortisone; Desoxycorticosterone; Desoxycorticosterone | 1954 |
[Vascular reactions in hypertension after application of ACTH, DOCA, agovirin and agostilben].
Topics: Adrenocorticotropic Hormone; Blood Vessels; Desoxycorticosterone; Desoxycorticosterone Acetate; Diet | 1955 |
The comparative activities of delta1, 4 pregnadiene-21-ol-3, 20-dione acetate and desoxycorticosterone acetate in the rat.
Topics: Acetates; Adrenal Cortex; Adrenal Cortex Hormones; Animals; Desoxycorticosterone Acetate; Hypertensi | 1955 |
Studies of certain antihistamines as antagonists of the hypertensive and angiotoxic properties of desoxycorticosterone acetate in the rat.
Topics: Animals; Anti-Allergic Agents; Desoxycorticosterone; Desoxycorticosterone Acetate; Histamine Antagon | 1956 |
Depletion of carcass potassium in rats made hypertensive with desoxycorticosterone acetate (DCA) and with cortisone.
Topics: Animals; Cortisone; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Potassium; Pot | 1957 |
[Effect of testosterone on the development of arterial hypertension and of nephrosclerosis caused by overload of desoxycorticosterone acetate (DCA) in rats].
Topics: Animals; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Nephrosclerosis; Rats; Te | 1960 |
On vascular lesions in rats with high blood pressure due to desoxycorticosterone acetate (DCA) overdosage. II. Kidney arterioles wall to lumen ratio.
Topics: Animals; Arterioles; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Kidney; Rats | 1960 |
Hypophysectomy and DOCA hypertension. A comparison between male and female rats.
Topics: Animals; Desoxycorticosterone; Desoxycorticosterone Acetate; Female; Hypertension; Hypophysectomy; M | 1962 |
CYTOLOGICAL STUDIES ON THE POSSIBLE SITES OF RENIN FORMATION IN HYPERTENSIVE RATS BY DOCA, CORTISONE AND THYROXINE.
Topics: Cortisone; Desoxycorticosterone; Desoxycorticosterone Acetate; Histological Techniques; Hypertension | 1963 |
EFFECTS OF CHRONIC EXCESS SALT INGESTION. ROLE OF GENETIC FACTORS IN BOTH DOCA-SALT AND RENAL HYPERTENSION.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone; Desoxycorticosterone Ac | 1963 |
[PRELIMINARY STUDIES IN BILATERAL RENAL ISCHEMIA. INFLUENCE OF DOCA AND PROGESTERONE ON NATRIURESIS AND URINARY VOLUME].
Topics: Cats; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Hypertension, Renal; Kidney; | 1964 |
STEROID BIOSYNTHESIS BY RAT ADRENAL: DURING DEVELOPMENT OF ADRENAL REGENERATION AND DESOXYCORTICOSTERONE ACETATE-INDUCED HYPERTENSION.
Topics: Acetates; Adrenal Glands; Adrenalectomy; Aldosterone; Chromatography; Corticosterone; Desoxycorticos | 1964 |
CORONARY ATHEROSCLEROSIS. I. CONTRAST OF DOCA HYPERTENSION WITH RENAL HYPERTENSION IN THE ETIOLOGY OF CORONARY ATHEROSCLEROSIS IN THE ADULT MALE WISTAR RAT.
Topics: Animals; Coronary Artery Disease; Coronary Disease; Desoxycorticosterone; Desoxycorticosterone Aceta | 1965 |
[Effects of ACTH, cortisone and vitamin C on experimental hypertension induced by desoxycorticosterone acetate].
Topics: Adrenocorticotropic Hormone; Ascorbic Acid; Cortisone; Desoxycorticosterone; Desoxycorticosterone Ac | 1955 |
[Neurosecretion of the supraoptic and paraventricular nuclei in prolonged experimental nephrogenic hypertension; effect of the administration of desoxycorticosterone acetate].
Topics: Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; Hypothalamus; Neurosecretion | 1955 |
Experimental hypertensive vascular disease in the rat; a histopathologic study of the lesions produced by methylandrostenediol and desoxycorticosterone acetate.
Topics: Androgens; Animals; Blood Vessels; Desoxycorticosterone; Desoxycorticosterone Acetate; Hypertension; | 1955 |
Potentiation of pressor effects of nor-epinephrine and epinephrine in man by desoxycorticosterone acetate.
Topics: Adrenal Cortex Hormones; Blood Pressure; Desoxycorticosterone Acetate; Epinephrine; Humans; Hyperten | 1950 |
[Cases of hypertension provoked by desoxycorticosterone acetate].
Topics: Adrenal Cortex Hormones; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; | 1950 |
Hypertensive disease produced by desoxycorticosterone acetate in parabiotic rats.
Topics: Adrenal Cortex Hormones; Animals; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone | 1951 |
Effects of adrenalectomy, desoxycorticosterone acetate and increased fluid intake on intake of sodium chloride and bicarbonate by hypertensive and normal rats.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Animals; Bicarbonates; Blood Pressure; Blood Pressure Determ | 1951 |
Sustained hypertension following the administration of desoxycorticosterone acetate.
Topics: Adrenal Cortex Hormones; Animals; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; Kidney | 1951 |
[Effect of ascorbic acid on hypertension induced by desoxycorticosterone acetate].
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Blood Pressure; Blood Pressure Determination; Desoxycorticos | 1951 |
[Production of hypertension in man by desoxycorticosterone acetate].
Topics: Adrenal Cortex Hormones; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone Acetate; | 1951 |
The effect of adrenal cortical extract, 11-desoxy-17-hydroxycorticosterone acetate (compound S) and 11-dehydrocorticosterone acetate (compound A) on the cardiovascular-renal action of desoxycorticosterone acetate.
Topics: Acetates; Adrenal Cortex; Adrenal Cortex Hormones; Cardiovascular System; Corticosterone; Cortodoxon | 1951 |
Pressor effects of epinephrine, norepinephrine and desoxycorticosterone acetate weakened by sodium withdrawal.
Topics: Desoxycorticosterone; Desoxycorticosterone Acetate; Diet; Epinephrine; Hypertension; Norepinephrine; | 1952 |
Observations on the pregnant rat injected with nephrotoxic rabbit anti-rat placenta serum and desoxycorticosterone acetate.
Topics: Animals; Blood Pressure; Desoxycorticosterone Acetate; Female; Hypertension; Kidney; Nephritis; Plac | 1949 |
Observations on the role of the rat kidney in hypertension caused by desoxycorticosterone acetate.
Topics: Adrenal Glands; Animals; Blood Pressure; Desoxycorticosterone; Desoxycorticosterone Acetate; Hyperte | 1949 |
Effects of adrenalectomy and of adrenal cortical extract on desoxycorticosterone acetate-hypertension in the rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Blood Pressure; Blood Pressure Determination; Desoxycorticos | 1949 |