desonide and Psoriasis

Topics: Adolescent; Adult; Aged; Budesonide; Child; Clinical Trials as Topic; Desonide; Double-Blind Method; Female; Humans; Male; Middle Aged; Ointments; Pregnadienetriols; Pregnenediones; Psoriasis

This was a double-blind, randomized, parallel-groups comparison of alclometasone dipropionate and desonide ointments (0.05%) applied twice daily without occlusion for 3 weeks by patients with moderate to severe psoriasis. Data from thirty-three patients in each group showed that both treatments produced rapid amelioration of erythema, induration, and, especially, scaling; substantial improvement was evident after 1 week and continued thereafter. Differences between the groups were not statistically significant, but trends consistently favoured alclometasone. No adverse drug reaction occurred.

Topics: Administration, Topical; Adolescent; Adult; Aged; Clinical Trials as Topic; Desonide; Double-Blind Method; Female; Humans; Male; Methylprednisolone; Middle Aged; Ointments; Pregnadienetriols; Psoriasis

Although there is a variety of animal models available, neither a single assay system nor the results of the various assays permit absolute protection of relative anti-inflammatory potency. Equally, current clinical dose titration studies, although more reliable, provide only gross estimates of therapeutic potency when conducted in certain clinical situations in a double-blind randomized fashion. This paper delineated clinical means to titrate more objectively and accurately therapeutic potency in the patient. Moreover, it has submitted considerations as to how to assess therapeutic anti-inflammatory activity in the complex multi-component process of inflammation accompanying most dermatologic diseases that eventually may permit titration of specific anti-inflammatory compounds on certain tissue components of the inflammatory process.

Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Clinical Trials as Topic; Desonide; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclinical; Edema; Eye Diseases; Female; Fibroblasts; Glucocorticoids; Humans; Inflammation; Mitosis; Psoriasis; Rabbits; Triamcinolone Acetonide; Vagina; Vasoconstrictor Agents

Topics: Adult; Betamethasone; Biopsy; Dermatomycoses; Desonide; Diagnostic Errors; Herpes Genitalis; Humans; Immunosuppressive Agents; Male; Penile Diseases; Propylene Glycol; Psoriasis; Recurrence

The link between guttate psoriasis and streptococcal infection is acknowledged. This form of psoriasis generally follows pharyngitis, but a small number of cases have been described as being triggered by a streptococcal infection other than in the throat. We report the case of a child with streptococcal anitis followed by guttate psoriasis.. A 4-year-old boy presented painful perianal erythema present for two weeks with diffuse lesions of guttate psoriasis present since the second week. Group A beta-haemolytic streptococcus was found during bacterial examination of the anal region. After one month of antibiotic treatment with josamycin combined with daily application of desonide 0.05% topical cream, all symptoms subsided without relapse in the ensuing 6 months.. This case demonstrates the need for careful clinical examination, both of the nose and throat but also of the perianal region, in children consulting for guttate psoriasis. It also demonstrates the strong link between guttate psoriasis and streptococcal infections in certain patients.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Anus Diseases; Child, Preschool; Dermatitis; Desonide; Humans; Josamycin; Male; Psoriasis; Streptococcal Infections