desonide has been researched along with Inflammation* in 2 studies
1 trial(s) available for desonide and Inflammation
| Article | Year |
|---|---|
Dose titration of steroidal and non-steroidal topical anti-inflammatory agents.
Although there is a variety of animal models available, neither a single assay system nor the results of the various assays permit absolute protection of relative anti-inflammatory potency. Equally, current clinical dose titration studies, although more reliable, provide only gross estimates of therapeutic potency when conducted in certain clinical situations in a double-blind randomized fashion. This paper delineated clinical means to titrate more objectively and accurately therapeutic potency in the patient. Moreover, it has submitted considerations as to how to assess therapeutic anti-inflammatory activity in the complex multi-component process of inflammation accompanying most dermatologic diseases that eventually may permit titration of specific anti-inflammatory compounds on certain tissue components of the inflammatory process. Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Clinical Trials as Topic; Desonide; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclinical; Edema; Eye Diseases; Female; Fibroblasts; Glucocorticoids; Humans; Inflammation; Mitosis; Psoriasis; Rabbits; Triamcinolone Acetonide; Vagina; Vasoconstrictor Agents | 1975 |
1 other study(ies) available for desonide and Inflammation
| Article | Year |
|---|---|
Comparison of the effects of a non-steroidal anti-inflammatory agent, an immunosuppressive, a corticosteroid and an immunomodulator on various immunological and non-immunological inflammatory experimental models.
The effects of a non-steroidal anti-inflammatory agent, phenylbutazone, a corticosteroid, desonide, an immunosuppressive, cyclophosphamide and an immunomodulator, levamisole on a number of experimental inflammatory models were compared. Compounds were first tested in carrageenin-induced pleurisy as a non-immune acute inflammation, then in passive skin anaphylaxis and reversed passive Arthus oedema in the rat as models of humoral immunity. Finally the compounds were investigated in various delayed hypersensitivity tests: reaction to sheep red cells and to oxazolone in the mouse, skin reaction to purified protein derivative (P.P.D.) in the rat and guinea-pig, P.P.D. induced pleurisy in the guinea-pig. Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Carrageenan; Cyclophosphamide; Desonide; Glucocorticoids; Guinea Pigs; Hypersensitivity, Delayed; Immunosuppressive Agents; Inflammation; Levamisole; Mice; Passive Cutaneous Anaphylaxis; Phenylbutazone; Rats | 1979 |