desonide and Atrophy

desonide has been researched along with Atrophy* in 2 studies

Other Studies

2 other study(ies) available for desonide and Atrophy

ArticleYear
Steroid problems.
    International journal of dermatology, 1979, Volume: 18, Issue:9

    Topics: Atrophy; Desonide; Humans; Pregnadienetriols; Skin Diseases

1979
Corticosteroid-induced dermal atrophy in the rat.
    The Journal of investigative dermatology, 1977, Volume: 69, Issue:5

    Corticosteroid-induced dermal atrophy has been studied in the rat using daily application of ethanolic solutions to small areas of flank skin. After 12 days of treatment, the degree of atrophy was determined by comparing the weights of skin plugs (16 mm diameter) taken from the treated areas with contralaterally paired control areas. Doses can be adjusted so that systemic effects are minimized and only local effects are observed. Hydrocortisone, hydrocortisone butyrate, dexamethasone, betamethasone, desonide and triamcinolone acetonide all produce atrophy in the rat, and the degree of thinning is dose dependent. Potencies in the dermal atrophy assay compare directly with topical anti-inflammatory potencies in the rat, and the presence of fluorine in the steroid molecule is not a determining factor in the production of atrophy.

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Atrophy; Betamethasone; Desonide; Dexamethasone; Hydrocortisone; Male; Rats; Skin; Triamcinolone Acetonide

1977