desnitroimidacloprid has been researched along with Neuroblastoma* in 1 studies
1 other study(ies) available for desnitroimidacloprid and Neuroblastoma
| Article | Year |
|---|---|
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.
Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of this pesticide family form a set of diverse metabolites within crops. Among these, desnitro-imidacloprid (DN-IMI) is of special toxicological interest, as there is evidence (i) for human dietary exposure to this metabolite, (ii) and that DN-IMI is a strong trigger of mammalian nicotinic responses. We set out here to quantify responses of human nAChRs to DN-IMI and an alternative metabolite, IMI-olefin. To evaluate toxicological hazards, these data were then compared to those of IMI and nicotine. Ca Topics: Alkenes; Animals; Cell Line; Cell Line, Tumor; Humans; Imidazolines; Molecular Docking Simulation; Neonicotinoids; Neuroblastoma; Neurons; Nicotinic Agonists; Nitro Compounds; Oocytes; Pesticides; Pyridines; Receptors, Nicotinic; Signal Transduction; Xenopus laevis | 2021 |