desmosterol and Arteriosclerosis

desmosterol has been researched along with Arteriosclerosis* in 4 studies

Trials

1 trial(s) available for desmosterol and Arteriosclerosis

ArticleYear
Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project.
    The Journal of nutrition, 2001, Volume: 131, Issue:7

    Plant sterol supplementation reduces serum cholesterol concentration but may increase serum plant sterol concentrations, especially in children. We determined whether natural dietary plant sterols derived mainly from vegetable oil or margarine in early childhood affect serum concentrations of plant sterols (campesterol and sitosterol) and cholesterol precursor sterols (Delta-8 cholestenol, desmosterol, and lathosterol), reflecting endogenous cholesterol synthesis. We measured the serum sterol concentrations using gas liquid chromatography in 20 healthy 13-mo-old intervention children in a randomized, prospective study designed to decrease exposure of the children to known environmental atherosclerosis risk factors and in 20 control children. The diet of the intervention children was rich in plant sterols due to replacement of milk fat with vegetable fat, whereas the diet of the control children contained only small amounts of plant sterols. The intervention children consumed twice as much plant sterols as the control children (P < 0.001). Their serum concentrations of campesterol and sitosterol were 75% and 44% higher, respectively, than those in the control children (P < 0.001 for both), but serum cholesterol precursor sterol concentrations did not differ between the two groups. We conclude that doubling dietary plant sterol intake almost doubles serum plant sterol concentrations in 13-mo-old children, but has no effect on endogenous cholesterol synthesis. Relative intestinal absorption of natural plant sterols from the diet in early childhood is similar to that in adults.

    Topics: Arteriosclerosis; Case-Control Studies; Cholesterol; Chromatography, Gas; Desmosterol; Diet Records; Female; Humans; Hypolipidemic Agents; Infant; Intestinal Absorption; Male; Margarine; Phytosterols; Plant Oils; Prospective Studies; Risk Factors; Sitosterols

2001

Other Studies

3 other study(ies) available for desmosterol and Arteriosclerosis

ArticleYear
TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY.
    Journal of lipid research, 1965, Volume: 6

    Topics: Arteries; Arteriosclerosis; Cholecalciferol; Cholesterol; Chromatography; Coronary Disease; Desmosterol; Drug Therapy; Lipid Metabolism; Tissue Distribution; Triparanol

1965
Desmosterol deposition in human and experimental atherosclerosis.
    Circulation research, 1963, Volume: 12

    Topics: Alcohols; Arteriosclerosis; Atherosclerosis; Desmosterol; Humans; Sterols

1963
Deposition of desmosterol in the lesions of experimental atherosclerosis.
    Lancet (London, England), 1962, Mar-17, Volume: 1, Issue:7229

    Topics: Arteriosclerosis; Atherosclerosis; Desmosterol; Humans; Sterols

1962